Tesi sul tema "GYF domain"
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Georgiev, Alexander. "Membrane Stress and the Role of GYF Domain Proteins". Doctoral thesis, Stockholm : Department of Biochemistry and Biophysics, Stockholm university, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7764.
Albert, Gesa Ines [Verfasser]. "Functional characterization of GYF-domain containing proteins / Gesa Ines Albert". Berlin : Freie Universität Berlin, 2012. http://d-nb.info/1026695856/34.
Mansour, Hala. "Characterization of GEXP15 as a potential regulator of protein phosphatase 1 in Plasmodium falciparum". Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS068.
Malaria is one of the most prevalent vector-borne infectious diseases threatening 40% of the global population, causing around 300 million cases and 450,000 deaths annually, mostly affecting children under 5. With no effective vaccine and drug resistance emerging, there is an urgent need for innovative treatments. The malaria-causing Plasmodium parasite has a complex life cycle and unique cell division process. Compared to well-studied systems, limited knowledge of Plasmodium biology hampers therapeutic development. Protein phosphorylation, a key regulatory mechanism, is less understood in Plasmodium than in mammalian or yeast cells. Kinases and phosphatases involved in phosphorylation and dephosphorylation processes respectively are potential drug targets. The Protein Phosphatase type 1 catalytic subunit (PP1c) (PF3D7_1414400) operates in combination with various regulatory proteins to specifically direct and control its phosphatase activity. However, there is little information about this phosphatase and its regulators in the human malaria parasite, Plasmodium falciparum. To address this knowledge gap, we conducted a comprehensive investigation into the structural and functional characteristics of a conserved Plasmodium-specific regulator called Gametocyte EXported Protein 15, GEXP15 (PF3D7_1031600). Through in silico analysis, we identified three significant regions of interest in GEXP15: an N-terminal region hous-ing a PP1-interacting RVxF motif, a conserved domain whose function is unknown, and a GYF-like domain that potentially facilitates specific protein-protein interactions. To further elucidate the role of GEXP15, we conducted in vitro interaction studies that demonstrated a direct interaction between GEXP15 and PP1 via the RVxF-binding motif. This interaction was found to enhance the phosphatase activity of PP1. Additionally, utilizing a transgenic GEXP15-tagged line and live microscopy, we observed high expression of GEXP15 in late asexual stages of the parasite, with localization predominantly in the nucleus. Immunoprecipitation assays followed by mass spectrometry analyses revealed the interaction of GEXP15 with ribosomal- and RNA-binding proteins. Furthermore, through pull-down analyses of recombinant functional domains of His-tagged GEXP15, we confirmed its binding to PfPP1 and to the ribosomal complex via the GYF domain. Collectively, our study sheds light on the PfGEXP15-PP1-ribosome interaction, which plays a crucial role in protein translation. These findings suggest that PfGEXP15 could serve as a potential target for the development of malaria drugs
Kofler, Michael. "GYF domains a class of proline rich ligand binding adaptor domains /". kostenfrei, 2007. http://www.diss.fu-berlin.de/2007/261/index.html.
Sekharan, Monica R. "Structural studies of the cGMP-binding GAF domain of PDE5A /". Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/8502.
Lee, Hyung Suk 1971. "Proximity of body & mind : urban gym as a heterotopic domain". Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/68380.
Includes bibliographical references (p. 78-79).
In the present urban space, where an individual is exposed to the conditions of heterogeneity and anonymity, a conventional Bodybuilding Gym opens up certain issues of emplacement of un/nder-spoken men's body and its close(t)ed placement in the society. While the rituals of entering and exiting the gym and 'building' the muscularity raise questions of men's reflected societal states in North America, the changing social appreciation of the 'new' body images, and emerging holistic approach of wellness of body-mind have become the thresholds to rethink the previously hyper-masculine gym space and to reinvent a way to accommodate these new conditions. I have explored the design of a contemporary gym as a subterranean-heterotopic- site rooted in the current urban context to reflect its various and changing socio-spatial identities of each user. The design focus is to recognize the updated characteristics of the user spaces when the gym is introduced with the new programs of Totality of Body-Mind, or, a further embodied Mind Zone coming into the body activity program concepts, to create new physical and psychological inter-relationships, or Proximity of Heterotopic Stages, to the individual users.
by Hyung Suk Lee.
M.Arch.
Alharbi, Mona. "Structural investigation of the GAF domain protein BPSL2418 from Burkholderia pseudomallei". Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/8314/.
Libiad, Marouane. "La free R Méthionine sulfoxyde réductase (fRMsr) de Neisseria meningitidis : Mécanisme, catalyse et spécificité structurale". Thesis, Université de Lorraine, 2012. http://www.theses.fr/2012LORR0335/document.
Methionine sulfoxide reductases (Msr) catalyze the specific reduction of methionine sulfoxides (Met-O) into methionine (Met). They are involved in cell defences against oxidative stress and virulence of pathogenic bacteria of Neisseria genius. This family of enzymes consists of three classes, MsrA and MsrB, structurally-unrelated, Specific for the S and the R epimer of the sulfoxide function of the substrate, respectively. A third class, recently discovered and called fRMsr, selectively reduce the free form of the R epimer of the sulfoxide function. The fRMsr belongs to the family of GAF domains, they are usually involved in cell signaling, and fRMsr represent the first GAF domain to show enzymatic activity. The studies of the Neisseria meningitidis fRMsr have shown that: 1) The Neisseria meningitidis fRMsr have a identical catalytic mechanism to MsrA and MsrB with the formation of at least one intramolecular disulfide bond, Cys84-Cys118 reduced by thioredoxin (Trx) ; 2) The Cys118 is demonstrated to be the catalytic Cys on which a sulfenic acid is formed ; 3) The Reductase step is the rate determining step of the mechanism leading to the formation of the disulfide bond Cys84-Cys118. The combination of the biochemical and kinetics data, and the examination of the 3D structure of the N. meningitidis fRMsr in complex with its substrate shown: 1) an oxyanion hole involved in the accommodation of the carboxylate group ; 2) the carboxylate group of the Asp143 residue involved in the catalysis of step reductase, and 3) The Glu125 residue involved in the recognition and/or positioning of the Met-O probably by the stabilization of the NH3+; 4) the Asp141 residue involved in the positioning of Asp143 and Glu125 residues ; 5) the indole ring of the Trp62 residue involved in stabilizing of the epsilon-methyl group
Rao, Shuyun. "Vav3 Potentiation of Androgen Receptor Activity in Prostate Cancer". Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_dissertations/359.
Wu, Albert Ya-Po. "Molecular mechanism of cyclic nucleotide binding to the GAF domains of phosphodiesterases 2 and 5 /". Thesis, Connect to this title online; UW restricted, 2003. http://hdl.handle.net/1773/5012.
Lim, Wei Ming. "Design of application specific instruction set processors for the domain of GF(2'm)". Thesis, University of Sheffield, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.412439.
Estrach, Soline. "Etude du Rho-GEF Trio dans la morphologie neuronale et caractérisation des partenaires de son domaine SH3-1". Montpellier 2, 2002. http://www.theses.fr/2002MON20068.
Buchner, Kristina [Verfasser], e Esther [Akademischer Betreuer] Zanin. "Functional characterization of the BRCT domains of the RhoA GEF Ect2 during cell division / Kristina Buchner ; Betreuer: Esther Zanin". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2019. http://d-nb.info/1234911396/34.
Ševčík, Marek. "Návrh marketingové strategie". Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2021. http://www.nusl.cz/ntk/nusl-442904.
Wu, Hao. "Autour les relations entre SLE, CLE, champ libre Gaussien, et les conséquences". Phd thesis, Université Paris Sud - Paris XI, 2013. http://tel.archives-ouvertes.fr/tel-00856599.
De, Antoni Anna. "Structural and functional analysis of yeast proteins involved in ER-to-Golgi transport Sec24p family proteins and the GTPase activating protein Gyp5p /". Doctoral thesis, [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962093610.
Scarlato, Michele. "Sicurezza di rete, analisi del traffico e monitoraggio". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2012. http://amslaurea.unibo.it/3223/.
Kofler, Michael [Verfasser]. "GYF domains : a class of proline rich ligand binding adaptor domains / vorgelegt von Michael Kofler". 2007. http://d-nb.info/984979549/34.
ELOUMRI, Eloumri Miloud Salem S. "GRAPHICAL EDITORS GENERATION WITH THE GRAPHICAL MODELING FRAMEWORK: A CASE STUDY". Thesis, 2011. http://hdl.handle.net/1974/6366.
Thesis (Master, Computing) -- Queen's University, 2011-04-14 18:58:08.797
Human, Anja. "'n Verkennende ondersoek na kennis- en praktykstandaarde vir die getalledomein in die voorbereiding van grondslagfase-onderwysers / Anja Human". Thesis, 2014. http://hdl.handle.net/10394/11042.
MEd (Mathematics Education), North-West University, Potchefstroom Campus, 2014