Articoli di riviste sul tema "Griffith (N.S.W.)"

Central Mexico is considered a center of genetic diversity for Phytophthora infestans on the basis of a range of genotypic and phenotypic characteristics (3). Surprisingly, while mitochondrial DNA (mtDNA) haplotypes I-a, II-a, and II-b have been reported from central Mexico, haplotype I-b has not been found in central Mexico (1). Therefore, a more extensive search for haplotypes was conducted in areas where sexual reproduction occurs. During the summer of 2003, leaflets of cvs. Rosita and Tollocan with a single lesion of late blight were collected in the area of Villarreal, located in Terrenate County in Tlaxcala, Mexico (170 km northeast of Mexico City). Fourteen P. infestans isolates were characterized for mtDNA haplotype, isozyme genotype (glucose 6- phosphate isomerase [Gpi] and peptidase [Pep]), and mating type. Isolation, mating type, and isozyme genotype were characterized following reported protocols (1,4). MtDNA haplotype was determined by amplifying and digesting the P2 and P4 regions and comparing amplicons to those of reference strains of known haplotype (1,2). Twelve isolates were mtDNA haplotype I-a and two were I-b. While the mtDNA I-b has been associated with the US-1 lineage (mating type: A1, Gpi: 86/100, Pep: 92/100), the genotypes for the Mexican isolates were A2, 86/100 Gpi, 100/100 Pep from cv. Rosita and A2, 86/100 Gpi, 92/100 Pep from cv. Tollocan. To our knowledge, this is the first report of the I-b mtDNA haplotype of P. infestans from central Mexico and it is now clear that all four haplotypes exist in Mexico. This finding therefore, stresses the importance of including a representative regional sampling of Mexican and Andean isolates in studies inferring the origin of this species. References: (1) W. G. Flier et al. Phytopathology 93:382, 2003. (2) G. W. Griffith and D. S. Shaw. Appl. Environ. Microbiol. 64:4007, 1998. (3) N. J. Grünwald and W. G. Flier. Ann. Rev. Phytopathol. 43:171, 2005. (4) N. J. Grünwald et al. Phytopathology 91:882, 2001.

-Michael D. Olien, Edmund T. Gordon, Disparate Diasporas: Identity and politics in an African-Nicaraguan community.Austin: University of Texas Press, 1998. xiv + 330 pp.-Donald Cosentino, Margarite Fernández Olmos ,Sacred possessions: Vodou, Santería, Obeah, and the Caribbean. New Brunswick NJ: Rutgers University Press, 1997. viii + 312 pp., Lizabeth Paravisini-Gebert (eds)-John P. Homiak, Lorna McDaniel, The big drum ritual of Carriacou: Praisesongs in rememory of flight. Gainesville: University Press of Florida, 1998. xiv + 198 pp.-Julian Gerstin, Gerdès Fleurant, Dancing spirits: Rhythms and rituals of Haitian Vodun, the Rada Rite. Westport CT: Greenwood, 1996. xvi + 240 pp.-Rose-Marie Chierici, Alex Stepick, Pride against Prejudice: Haitians in the United States. Boston: Allyn & Bacon, 1998. x + 134 pp.-Rose-Marie Chierici, Flore Zéphir, Haitian immigrants in Black America: A sociological and sociolinguistic portrait. Westport CT: Bergin & Garvey, 1996. xvi + 180 pp.-Luis Martínez-Fernández, Rosalie Schwartz, Pleasure Island: Tourism and temptation in Cuba. Lincoln: University of Nebraska Press, 1997. xxiv + 239 pp.-Jorge L. Giovannetti, My footsteps in Baraguá. Script and direction by Gloria Rolando. VHS, 53 minutes. Havana: Mundo Latino, 1996.-Gert Oostindie, Mona Rosendahl, Inside the revolution: Everyday life in socialist Cuba. Ithaca: Cornell University Press, 1997. x + 194 pp.-Frank Argote-Freyre, Lisa Brock ,Between race and empire: African-Americans and Cubans before the Cuban revolution. Philadelphia: Temple University Press, 1998. xii + 298 pp., Digna Castañeda Fuertes (eds)-José E. Cruz, Frances Negrón-Muntaner ,Puerto Rican Jam: Rethinking colonialism and nationalism. Minneapolis: University of Minnesota Press, 1997. x + 303 pp., Ramón Grosfoguel (eds)-Helen I. Safa, Félix V. Matos Rodríguez ,Puerto Rican Women's history: New perspectives. Armonk NY: M.E. Sharpe, 1998. x + 262 pp., Linda C. Delgado (eds)-Arlene Torres, Jean P. Peterman, Telling their stories: Puerto Rican Women and abortion. Boulder CO: Westview Press, 1996. ix + 112 pp.-Trevor W. Purcell, Philip Sherlock ,The story of the Jamaican People. Kingston: Ian Randle; Princeton: Markus Wiener, 1998. xii + 434 pp., Hazel Bennett (eds)-Howard Fergus, Donald Harman Akenson, If the Irish ran the world: Montserrat, 1630-1730. Liverpool: Liverpool University Press, 1997. xii + 273 pp.-John S. Brierley, Lawrence S. Grossman, The political ecology of bananas: Contract farming, peasants, and agrarian change in the Eastern Caribbean. Chapel Hill: University of North Carolina Press, 1998. xx + 268 pp.-Mindie Lazarus-Black, Jeannine M. Purdy, Common law and colonised peoples: Studies in Trinidad and Western Australia. Aldershot, UK: Ashgate Dartmouth, 1997. xii + 309.-Stephen Slemon, Barbara Lalla, Defining Jamaican fiction: Marronage and the discourse of survival. Tuscaloosa: University of Alabama Press, 1996. xi + 224 pp.-Stephen Slemon, Renu Juneja, Caribbean transactions: West Indian culture in literature.-Sue N. Greene, Richard F. Patteson, Caribbean Passages: A critical perspective on new fiction from the West Indies. Boulder CO: Lynne Rienner Publishers, 1998. ix + 187 pp.-Harold Munneke, Ivelaw L. Griffith ,Democracy and human rights in the Caribbean. Boulder CO: Westview Press, 1997. vii + 278 pp., Betty N. Sedoc-Dahlberg (eds)-Francisco E. Thoumi, Ivelaw Lloyd Griffith, Drugs and security in the Caribbean: Sovereignty under seige. University Park: Penn State University Press, 1997. xx + 295 pp.-Michiel Baud, Eric Paul Roorda, The dictator next door: The good neighbor policy and the Trujillo regime in the Dominican republic, 1930-1945. Durham NC: Duke University Press, 1998. xii + 337 pp.-Peter Mason, Wim Klooster, The Dutch in the Americas 1600-1800. Providence RI: The John Carter Brown Library, 1997. xviii + 101 pp.-David R. Watters, Aad H. Versteeg ,The archaeology of Aruba: The Tanki Flip site. Oranjestad; Archaeological Museum Aruba, 1997. 518 pp., Stéphen Rostain (eds)

BackgroundMupadolimab (mupa) is a humanized FcγR binding-deficient IgG1 anti-CD73 antibody that has agonistic properties.1 CD73 is involved in production of adenosine and in cellular trafficking. Mupa reacts with the majority of circulating B cells leading to activation and expression of differentiation markers CD69, CD138 and CD38, and transformation into plasmablasts with secretion of IgM and IgG. B cell activation provided the rationale to develop mupa for immunotherapy of cancer and Covid-19. Intratumor HPV specific B cells have been reported in HNSCC.2 This report describes properties of mupa and the early signs of clinical activity in HPV+ HNSCC.MethodsELISA and flow cytometry were used to measure binding of anti-CD73. Humanized NSG-SGM3 mice were used to evaluate effects of Mupa on human anti-SARS CoV2 spike protein (SP) response. CD73 expression in biopsies was measured by immunohistochemistry. Mupa (IV q 3 weeks) with or without pembrolizumab is being evaluated in an ongoing phase 1 trial in patients with refractory cancers.ResultsMupa binding to CD73 was blocked by APCP, an analog of adenosine diphosphate that locks CD73 in the closed conformation, indicating mupa binding to the open conformation. Cross blocking and cellular internalization studies showed that mupa is distinct from other anti-CD73 antibodies such as MEDI9447 and AD2. NSG-SGM3 mice were immunized with 50 µg SP subcutaneously and treated with mupa 10mg/kg or control IgG IP. Mupa treated animals mounted an antigen specific human anti-SP response; no antibody responses were seen in controls (P=0.02). In the dose-escalation portion of the phase 1 trial, mupa doses of ≥12 mg/kg saturated CD73 sites on circulating B cells. High stromal CD73 expression was observed in HPV+ HNSCC biopsies from 5 evaluable patients with chemotherapy and anti-PD1 refractory disease, and tumor regression was seen in 2 of these patients receiving 7 and 16 cycles of ≥12 mg/kg mupa without pembrolizumab. Safety of mupa+pembrolizumab was evaluated in 16 patients with no MTD reached and no changes in serum immunoglobulins. Transient reductions in circulating CD73 B cells were observed consistent with redistribution to lymphoid tissues.ConclusionsCD73 plays a role in B cell activation and differentiation. Mupa is an antibody with agonistic activity that stimulates B cells and enhances antigen specific antibody production. This activity supports a strategy to combine mupa with pembrolizumab to enhance both humoral and cellular immunity in the treatment of viral associated cancers such as HPV+HNSCC, and viral infections.Trial RegistrationNCT03454451ReferencesWillingham S, Criner G, Hill C, Hu S, Rudnick J, Daine-Matsuoka B, Hsieh J, Mashhedi H, Hotson A, Brody J, Marron T, Piccione E, Buggy J, Mahabhashyam S, Jones W, Mobasher M, Miller R. Characterization and Phase 1 trial of a B cell activating anti-CD73 antibody for the immunotherapy of COVID-19. medRxiv, 2020; https://doi.org/10.1101/2020.09.10.20191486.Wieland A, Patel M, Cardenas M, Eberhardt C, Hudson W, Obeng R, Griffith C, Wang X, Chen Z, Kissick H, Saba N, Ahmed R. Defining HPV-specific B cell responses in patients with head and neck cancer. Nature 2020; https://doi.org/10.1038/s41586-020-2931-3.Ethics ApprovalThe study was approved by Western IRB, approval number 1-1066703-1. Participants gave informed consent before taking part.

Covid-19 has changed the learning process from class attendance to distance learning using the Internet. Early childhood education is threatened to enter into the lost generation, due to distance learning, which causes confusion for teachers and parents to be able to provide the best stimulation for them. Therefore, the Indonesian government made a new policy on online learning. The objectives of this research are to find how effective at online learning policy formulation, how productive it is in policy implementation, and what are the obstacles of the implementation at Early-Childhood Education (ECE). This qualitative research uses a mixed method approach with an iterative analysis design, conducted in Central Java Province in 35 districts / cities with 1,899 respondents. Data collection techniques with open-closed questionnaires, study from 15 documentation, and in-depth interviews. Data analysis uses quantitative-qualitative software Nvivo12+, with Miles and Huberman models. The results showed the policy formulation of online learning at ECE has been effective. However, the implementation of online learning policy at ECE still takes a lot of effort to become more powerful in preventing a decline in learning. There are five obstacles in in applying this in the field, namely the ability of teachers, the ability of parents, economic capability, facility constraints, and pedagogical constraints. Keywords: Online Learning Policy; Children Engagement; Learning Management System References Allen, I. E., Seaman, J. (2013). Changing course: Ten years of tracking online education in the United States. ERIC, ISBN 0984028838. Asilestari, P. (2016). Komputer Interaktif sebagai Media Pengajaran Bahasa Inggris pada Anak Usia Dini. Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini, 2, n. 1, p. 55-62. Association, I. I. S. P. (2018). Penetrasi & Profil Perialku Pengguna Internet Indonesia. Coates, H. (2006). Student engagement in campus-based and online education: University connections. Routledge, ISBN 1134161530. Ha, Young. & Im, Hyunjoo. (2020). The Role of an Interactive Visual Learning Tool and its Personalizability in Online Learning: Flow Experience. Online Learning, 24, n. 1. Harjanto, T. & Sumunar, D. S. E. W. (2018). Tantangan Dan Peluang Pembelajaran Dalam Jaringan: Studi Kasus Implementas Elok (E-Learning: Open For Knowledge Sharing) Pada Mahasiswa Profesi Ners. Jurnal Keperawatan Respati Yogyakarta, 5, p. 24-28. Imron, A. (1995). Kebijaksanaan pendidikan di Indonesia: Proses, produk dan masa depannya. Bumi Aksara, ISBN 9795262319. Inoue, Y. (2007). Online education for lifelong learning. IGI Global, ISBN 1599043211. Irma, C. N., Nisa, K. & Sururiyah, S. K. (2019). Keterlibatan Orang Tua dalam Pendidikan Anak Usia Dini di TK Masyithoh 1 Purworejo. Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini, 3, n. 1, p. 214-224. Jebba, A. M. & Umaru, N. N. (2019). The role of social media in reshaping the academic activities of vocational and technical education lecturers in Nigeria. Int. J. Eval. & Res. Educ. Vol, 8, n. 4, p. 735-741. Johnson, K. & Manning, S. (2010). Online education for dummies. Canada: John Wiley & Sons Publishing ISBN 0470536209. Juwah, C. (2006). Interactions in online education: Implications for theory and practice. Routledge, ISBN 1134247494. Kemendikbud. (2020). Surat Edaran Nomor 4 Tahun 2020 Tentang Pelaksanaan Kebijakan Pendidikan Dalam Masa Darurat Penyebaran Corona Virus Disease (Covid-19). Kong, S. C., Chan, T.-W., Griffin, P. & Hoppe, U. et al. (2014). E-learning in school education in the coming 10 years for developing 21st century skills: Critical research issues and policy implications. Journal of Educational Technology & Society, 17, n. 1, p. 70-78. Kwon, J. B., Debruler, K. & Kennedy, K. (2019). A Snapshot of Successful K-12 Online Learning: Focused on the 2015-16 Academic Year in Michigan. Journal of Online Learning Research, 5, n. 2, p. 199-225. Layne, M., Boston, W. E. & Ice, P. (2013). A longitudinal study of online learners: Shoppers, swirlers, stoppers, and succeeders as a function of demographic characteristics. Online Journal of Distance Learning Administration, 16, n. 2, p. 1-12. Lynch, M. M. (2002). The online educator: A guide to creating the virtual classroom. Routledge, ISBN 1134542542. Novianti, R. & Garzia, M. (2020). Penggunaan Gadget Pada Anak; Tantangan Baru Orang Tua Milenial. Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini, 4, n. 2. Nugroho, R. (2008). Kebijakan Pendidikan: Pengantar untuk Memahami Kebijakan Pendidikan Sebagai Kebijakan Publik. Yogyakarta: Pustaka Pelajar. Nugroho, R. (2017). Public Policy: Dinamika Kebijakan, Analisis Kebijakan, dan Manajemen Politik Kebijakan Publik. Jakarta: Elex Media Komputindo. Palloff, R. M. & Pratt, K. (2002). Lessons from the cyberspace classroom: The realities of online teaching. California: John Wiley & Sons Publishing, ISBN 0787959960. Pangondian, R. A., Santosa, P. I. & Nugroho, E. (2019). Faktor-Faktor Yang Mempengaruhi Kesuksesan Pembelajaran Daring Dalam Revolusi Industri 4.0. Panjaitan, N. Q.; Yetti, E. & Nurani, Y. (2020). Pengaruh Media Pembelajaran Digital Animasi dan Kepercayaan Diri terhadap Hasil Belajar Pendidikan Agama Islam Anak. Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini, 4, n. 2, p. 588-596. Pebriana, P. H. (2017). Analisis penggunaan gadget terhadap kemampuan interaksi sosial pada anak usia dini. Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini, 1, n. 1, p. 1-11. Pertiwi, W. K. (2020). Penetrasi Internet di Indonesia Capai 64 Persen. https://tekno.kompas.com/read/2020/02/20/14090017/penetrasi-internet-di-indonesia-capai-64-persen. Ramadhan, B. (2020). Ini Data Pengguna Internet Di Seluruh Dunia Tahun 2020. Jakarta https://teknoia.com/data-pengguna-internet-dunia-ac03abc7476. Roach, V. & Lemasters, L. (2006). Satisfaction with online learning: A comparative descriptive study. Journal of Interactive Online Learning, 5, n. 3, p. 317-332. Rohita, R. (2020). The Ability of Ece Teachers to Use ICT in The Industrial Revolution 4.0. Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini, 4, n. 2, p. 502-511. Rostaminezhad, M., Mozayani, N., Norozi, D. & Iziy, M. (2013). Factors related to e-learner dropout: Case study of IUST elearning center. Procedia-Social and Behavioral Sciences, 83, p. 522-527. Sari, K. M. & Setiawan, H. (2020). Kompetensi Pedagogik Guru dalam Melaksanakan Penilaian Pembelajaran Anak Usia Dini. Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini, 4, n. 2, p. 900-912. Seok, S. & Dacosta, B. (2020). Relationships Between Young South Koreans’ Online Activities and Their Risk of Exploitation. Journal of Online Learning Research, 6, n. 1, p. 77-101. Setyaji, A., Iskak, A., Sukmaningrum, R. & Hawa, F. (2015). Komputer Interaktif Sebagai Media Pengajaran Bahasa Inggris Pada Anak Usia Dini. E-Dimas: Jurnal Pengabdian kepada Masyarakat, 6, n. 1, p. 1-12. Sharoff, L. (2019). Creative and Innovative Online Teaching Strategies: Facilitation for Active Participation. Journal of Educators Online, 16, n. 2, p. n2. Suhartanto, H. (2010). Survei 2009: Mutu Situs E-Learning Sekolah Indonesia Masih Sangat Minim. Jurnal Sistem Informasi,6, n. 1, p. 80-83. Sum, T. A. & Taran, E. G. M. (2020). Kompetensi Pedagogik Guru PAUD dalam Perencanaan dan Pelaksanaan Pembelajaran. Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini, 4, n. 2. Swan, K. (2003). Learning effectiveness online: What the research tells us. p.13-47. Taufik, A., Apendi, T., Saidi, S. & Istiarsono, Z. (2019). Parental Perspectives on the Excellence of Computer Learning Media in Early Childhood Education. Jurnal Pendidikan Usia Dini, 13, n. 2, p. 356-370. Tilaar, H.; Nugroho, R. (2009). Kebijakan Pendidikan: Pengantar untuk Memahami Kebijakan Pendidikan dan Kebijakan Pendidikan sebagai Kebijakan Publik. Yogyakarta: Pustaka Pelajar. Ulya, S. I. (2019). Analisis Penggunaan Gedget Terhadap Kemampuan Interaksi Sosial Dan Komunikasi Pada Anak Usia Dini. 89-96. Vonderwell, S. & Zachariah, S. (2005). Factors that influence participation in online learning. Journal of Research on Technology in education, 38, n. 2, p. 213-230. Wang, Q., Zhu, Z., Chen, L. & Yan, H. (2009). E‐learning in China. Campus-Wide Information Systems. Winter, J., Cotton, D., Gavin, J. & Yorke, J. D. (2010). Effective e-learning? Multi-tasking, distractions and boundary management by graduate students in an online environment. ALT-J, 18, n. 1, p. 71-83. Yu, E. (2020). Student-Inspired Optimal Design of Online Learning for Generation Z. Journal of Educators Online, 17, n. 1, p. n1. Zaini, M. & Soenarto, S. (2019). Persepsi Orangtua terhadap Hadirnya Era Teknologi Digital di Kalangan Anak Usia Dini. Jurnal Obsesi: Jurnal Pendidikan Anak Usia Dini, 3, n. 1, p. 254-264.

Fast transport of axonal vesicles and organelles is a microtubule-associated movement (Griffin, J. W., K. E. Fahnestock, L. Price, and P. N. Hoffman, 1983, J. Neuroscience, 3:557-566; Schnapp, B. J., R. D. Vale, M. P. Sheetz, and T. S. Reese, 1984, Cell, 40:455-462; Allen, R. D., D. G. Weiss, J. H. Hayden, D. T. Brown, H. Fujiwake, and M. Simpson, 1985, J. Cell Biol., 100:1736-1752). Proteins that mediate the interactions of axoplasmic vesicles and microtubules were studied using stable complexes of microtubules and vesicles (MtVC). These complexes formed spontaneously in vitro when taxol-stabilized microtubules were mixed with sonically disrupted axoplasm from the giant axon of the squid Loligo pealei. The isolated MtVCs contain a distinct subset of axoplasmic proteins, and are composed primarily of microtubules and attached membranous vesicles. The MtVC also contains nonmitochondrial ATPase activity. The binding of one high molecular mass polypeptide to the complex is significantly enhanced by ATP or adenyl imidodiphosphate. All of the axoplasmic proteins and ATPase activity that bind to microtubules are found in macromolecular complexes and appear to be vesicle-associated. These data allow the identification of several vesicle-associated proteins of the squid giant axon and suggest that one or more of these polypeptides mediates vesicle binding to microtubules.

Se analizó la relación entre el uso problemático de internet y la calidad de sueño. La metodología fue no experimental, transversal y correlacional. La muestra fue no probabilística por conveniencia. Participaron 118 estudiantes de pregrado y postgrado de universidades e institutos superiores de la ciudad de Quito en Ecuador. Los instrumentos fueron el Cuestionario de Experiencias Relacionadas con Internet (CERI) y el Cuestionario de Pittsburg de Calidad de Sueño (PSQI). Se evaluó la asociación entre las variables mediante el coeficiente de correlación de Pearson y un valor p < 0,05 durante la emergencia sanitaria por COVID-19. Los resultados muestran que los participantes en 51 % tienen problemas ocasionales con el uso de internet y el 47 % tienen problemas de sueño que además merecen atención y tratamiento médico. La asociación entre la variable independiente y la variable dependiente fue r = 0,195 y p = 0,034. En conclusión, existe una relación significativa moderada entre el uso problemático de internet y la calidad de sueño. Palabras Clave: Calidad de sueño, estudiantes universitarios, salud mental, uso de internet. [1]D. J. Kuss y O. López-Fernández, “Internet addiction and problematic Internet use: A systematic review of clinical research,” World journal of psychiatry vol. 6, n° 1, pp. 143-76, Marzo 2016. [2]M. Vázquez-Chacón, S. Cabrejos-Llontop, Y. Yrigoin-Pérez, R. Robles-Alfaro y C. Toro-Huamanchumo, “Adicción a internet y calidad de sueño en estudiantes de medicina de una Universidad peruana, 2016,” Revista Habanera de Ciencias Médicas, vol. 18, n° 5, pp. 817-830, Octubre 2019. [3]P. Carrillo-Mora, K. Barajas-Martínez, I. Sánchez-Vázquez y M. Rangel-Caballero, “Trastornos del sueño: ¿qué son y cuáles son sus consecuencias?,” Revista de la Facultad de Medicina de la UNAM, vol. 61, n° 1, pp. 6-20, Enero-febrero 2018. [4]S. J. Kim, J. W. Kim, Y. S. Cho, K. J. Chung, H. Yoon y K. H. Kim, “Influence of Circadian Disruption Associated With Artificial Light at Night on Micturition Patterns in Shift Workers,” International neurourology journal, vol. 23, n° 4, pp. 258-264, Diciembre 2019. [5]J. Arendt y B. Middleton, “Human seasonal and circadian studies in Antarctica (Halley, 75°S),” General and Comparative Endocrinology, vol. 258, n° 1, pp. 250-258, Marzo 2018. [6]P. Botero, P. Camargo, Y. Riaño y N. Velásquez, “Calidad del sueño en adultos según el grado de exposición a campos electromagnéticos en Bogotá y Duitama en 2017,” Tesis de pregrado, Universidad de Ciencias Aplicadas y Ambientales, Bogotá, COL., 2017. [7]H. Y. Wong, H. Y. Mo, M. N. Potenza, M. Chan, W. M. Lau, T. K. Chui, A. H. Pakpour y C. Y. Lin, “Relationships between Severity of Internet Gaming Disorder, Severity of Problematic Social Media Use, Sleep Quality and Psychological Distress,” International journal of environmental research and public health, vol. 17, n° 6, 1879, Marzo 2020. [8]V. Parra, J. Vargas, B. Zamorano, F. Peña, Y. Velázquez, L. Ruiz y O. Monreal, “Adicción y factores determinantes en el uso problemático del Internet, en una muestra de jóvenes universitarios,” Edutec-e, n° 56, p. a337, Junio 2016. [9]M. Laguna, “Estudio sobre el uso de internet y sus aplicaciones en el alumnado de último año de carrera de la Universidad de Alicante,” Tesis Doctoral, Universidad de Alicante, Alicante, ESP., 2013. [10]A. Rial, P. Gómez, M. Isorna, M. Araujo y J. Varela, “EUPI-a: Escala de Uso Problemático de Internet en adolescentes. Desarrollo y validación psicométrica,” Adicciones, vol. 27, n° 1, pp. 47-63, 2015. [11]T. Fernández-Villa, J. Alguacil, A. Almaraz, J. Cancela, M. Delgado-Rodríguez, M. García-Martín, E. Jiménez-Mejías, J. Llorca, A. Molina, R. Ortíz, L. Félix y V. Martín, “Uso problemático de internet en estudiantes universitarios: factores asociados y diferencias de género,” Adicciones, vol. 27, n° 4, pp. 265-275, 2015. [12]S. Cañón, J. Castaño, D. Hoyos, J. Jaramillo, D. Leal, R. Rincón, E. Sánchez y L. Urueña, “Uso problemático de internet en estudiantes universitarios: factores asociados y diferencias de género,” Adicciones, vol. 27, n° 4, pp. 265-275, Julio-diciembre 2016. [13]Z. Granados-Carrasco, A. Bartra-Aguinaga, D. Bendezú-Barnuevo, J. Huamanchumo-Merino, E. Hurtado-Noblecilla, J. Jiménez-Flores, F. León-Jiménez y D. Chang-Dávila, “Calidad del sueño en una facultad de medicina de Lambayeque,” Anales de la Facultad de Medicina, vol. 74, n°4, pp. 311-314, Octubre-Diciembre 2013. [14]Q. Wang, K. Mati y Y. Cai, “The link between problematic internet use, problematic gaming, and psychological distress: does sleep quality matter?,” BMC psychiatry, vol. 21, n° 1, 103, Febrero 2021. [15]M. Bautista y I. Taipe, “Calidad de sueño y factores asociados en internos rotativos de la carrera de Medicina de la Universidad de Cuenca 2019,” Tesis de pregrado Médico Cirujano, Universidad de Cuenca, Cuenca, ECU., 2019. [16]El Universo. (2020, Junio 26). El tráfico de internet en los hogares creció hasta 63 % en medio de la pandemia del COVID-19. Diario El Universo [Internet]. Disponible en: https://www.eluniverso.com/noticias/2020/06/23/nota/7881924/internet-fijo-servicio-operadoras-demanda-cuarentena-covid-19. [17]B. Fernandes, U. Nanda, R. Tan-Mansukhani, A. Vallejo y C. Essau, “The impact of COVID-19 lockdown on internet use and escapism in adolescents,” Revista de Psicología Clínica con Niños y Adolescentes, vol. 7, n° 3, pp. 59-65, Septiembre 2020. [18]J. A. Casas, R. Ruiz-Olivares y R. Ortega-Ruiz, “Validation of the Internet and Social Networking Experiences Questionnaire in Spanish adolescents,” International Journal of Clinical and Health Psychology, vol. 13, n° 1, pp. 40-48, Enero 2013. [19]Y. Tan, Y. Chen, Y. Lu y L. Li, “Exploring Associations between Problematic Internet Use, Depressive Symptoms and Sleep Disturbance among Southern Chinese Adolescents,”International journal of environmental research and public health, vol. 13, n° 3, 313, Marzo 2016. [20]A. Barquero y F. Calderón, “Influencia de las nuevas tecnologías en el desarrollo adolescente y posibles desajustes,” Revista Cúpula, vol. 30, n° 2, pp. 11-25, 2016. [21]J. P. C. Chang y C. C. Hung. Uso problemático de internet. Libro electrónico de IACAPAP de Salud Mental en Niños y Adolescentes. Geneva: Asociación Internacional de Psiquiatría y Profesiones Aliadas de Niños y Adolescentes. [Internet]. 2016. Disponible en: https://iacapap.org/content/uploads/H.6-Uso-problem%C3%A1tico-de-Internet-SPANISH-2017.pdf [22]S. García y G. Zurita, “Estudio estadístico de internet y su incidencia en la educación universitaria fiscal de la provincia del Guayas,” Tesis de pregrado Ingeniera en Estadística Informática, Escuela Superior Politécnica del Litoral (ESPOL), Guayaquil, ECU., 2017. [23]J. Redondo, K. Rangel, M. Luzardo y C. Inglés, “Experiencias relacionadas con el uso de internet y celular en una muestra de estudiantes universitarios colombianos,” Revista Virtual Universidad Católica del Norte, vol. 49, pp. 7-22, Septiembre-diciembre 2016. [24]S. Cruces, R. Guil, N. Sánchez y J. Pereira, “Consumo de nuevas tecnologías y factores de personalidad en estudiantes universitarios,” Commons, vol. 5, n° 2, pp. 203-228, Diciembre 2016. [25]X. Carbonell, A. Chamarro, M. Griffiths, U. Oberst, R. Cladellas y A. Talam, “Problematic Internet and cell phone use in Spanish teenagers and young students,” Anales de psicología, vol. 8, n° 3, pp. 789-796, Octubre 2012. [26]S. Iñiguez-Jiménez, S. Cruz-Pierard y S. Vaca-Córdova, “Uso problemático de tecnologías de la información y comunicación, consumo de sustancias y su impacto en la salud mental de estudiantes de bachillerato,” PAIDEIA XXI, vol. 10, n° 2, pp. 471-489, Julio-diciembre 2020. [27]M. Machado-Duque, J. Echeverri y J. Machado-Alba,"Somnolencia diurna excesiva, mala calidad del sueño y bajo rendimiento académico en estudiantes de Medicina,” Revista Colombiana de Psiquiatría, vol. 44, n° 3, pp. 137-142, Julio-septiembre 2015. [28]S. de la Portilla, C. Dussán, D. Montoya, J. Taborda y L. Nieto, “Calidad de sueño y somnolencia diurna excesiva en estudiantes universitarios de diferentes dominios,” Hacia Promoc. Salud, vol. 24, n° 1, pp. 84-96, Enero – junio 2019. [29]F. Wang y É. Bíró, “Determinants of sleep quality in college students: A literature review,” Explore, vol. 17, n° 2, pp. 170-177, Marzo-abril 2021. [30]M. Puerto, D. Rivero, L. Sansores, L. Gamboa y L. Sarabia, “Somnolencia, hábitos de sueño y uso de redes sociales en estudiantes universitarios,” Enseñanza e Investigación en Psicología, vol. 20, n° 2, pp. 189-195, Mayo-agosto 2015. [31]Ministerio de Sanidad. “COVID-19, consumo de sustancias psicoactivas y adicción”. Observatorio Español de las Drogas y las Adicciones, España. Informe Impacto COVID. [Internet]. Julio 2020. Disponible en: https://pnsd.sanidad.gob.es/noticiasEventos/actualidad/2020_Coronavirus/pdf/20200715_Informe_IMPACTO_COVID-19_OEDA_final.pdf

Background:Partial repair of bone erosions in rheumatoid arthritis (RA) is known from high-resolution peripheral quantitative computer tomography (HR-pQCT) studies in patients with moderate to high disease activity using biologics [1]. Whether RANKL inhibition by denosumab is efficacious in healing existing erosions in RA patients with low disease activity or in remission on conventional synthetic DMARDs is uncertain.Objectives:To evaluate the effects of denosumab on erosion healing at 2-4 metacarpophalangeal head as determined by HR-pQCT in patients with RA with stable disease.Methods:This was a randomized, placebo-controlled, double-blind study. RA patients with disease activity score 28 joints (DAS28) ≤5.1 were randomized (1:1) to subcutaneous denosumab 60 mg or placebo once every six months for 24 months. The primary outcome was erosion healing at MCP 2-4 on HR-pQCT at 12 months. The effects of denosumab on erosion and joint space parameters on HR-pQCT and radiographs, disease activity and health assessment questionnaire-disability index (HAQ-DI) were also examined.Results:At 24 months, HR-pQCT images were analyzed in 98 patients. Baseline demographic, clinical characteristics and imaging parameters were comparable between the two treatment groups (table 1). Seventeen patients in each group (placebo group: 17/52, 32.6%; denosumab group: 17/50, 34.0%) achieved sustained low disease activity (DAS28 ≤ 3.2) throughout the 24 months. At 12 months, changes in erosion parameters on HR-pQCT were similar between the two groups. At 24 months, new erosions (19% vs 9%, p=0.009) and erosion progression (34% vs 16%, p<0.001) were more common in the placebo group than the denosumab group. Erosion healing was seen in a significantly higher proportion of patients in the denosumab group (20% vs 6%, p=0.045) at 24 months. The details of the changes in HR-pQCT erosion parameters are shown in figure 1. No significant differences in the changes in joint space parameters on HR-pQCT, van der Heijde-Sharp erosion score, DAS28 and HAQ-DI were observed between the two groups at 12 and 24 months.Table 1.Baseline clinical, demographic, disease activity parameters and medicationsPlacebo (n=55)Denosumab (n=55)Total (n=110)Age56.5 ± 7.157.2 ± 8.556.8 ± 7.8Gender (Female)47 (86)41 (75)88 (80)Disease duration (years)8.5 ± 6.87.3 ± 6.97.9 ± 6.8Rheumatoid factor positive40 (72)38 (69)78 (71)ACPA positive43 (78)44 (80)87 (79)DAS28-CRP2.43 ± 0.832.6 ± 0.922.51 ± 0.88DAS28-CRP>3.28 (15)13 (24)21 (19)HAQ-DI (0-3)0.31 ± 0.380.46 ± 0.470.39 ± 0.43csDMARDs49 (89)52 (95)101 (92)Combination csDMARDs26 (47)33 (60)59 (54)Glucocorticoids5 (10)5 (9)10 (9)vdH- Sharp erosion score10.4 ± 18.48.9 ± 13.89.6 ± 16.2vdH- Sharp JSN score12.4 ± 17.711.5 ± 17.211.9 ± 17.4Lumbar spine aBMD, g/cm20.914 ± 0.1470.930 ± 0.1430.922 ± 0.145Total hip aBMD, g/cm20.837 ± 0.1020.847 ± 0.1460.841 ± 0.125Femoral neck aBMD, g/cm20.681 ± 0.0990.695 ± 0.1280.687 ± 0.114Data are reported as mean ± SD or number (%). ACPA: Anti-cyclic citrullinated peptide antibody; DAS28: disease activity score 28; csDMARDs: conventional synthetic disease modifying anti-rheumatic drug. HAQ-DI: health assessment questionnaire disability index; vdH- Sharp score: Van der Heijde- Sharp score; aBMD: areal bone mineral densityConclusion:Although no differences in erosion parameters were observed at 12 months, denosumab was more efficacious than placebo in erosion repair on HR-pQCT after 24 months.References:[1]Finzel S, Rech J, Schmidt S, et al. Interleukin-6 receptor blockade induces limited repair of bone erosions in rheumatoid arthritis: a micro CT study. Ann Rheum Dis 2013;72:396-400.Figure 1.Changes in erosion parameters by HR-pQCT. (A) Percentage of patients with overall erosion healing; (B) Outcome of individual erosion with healing, progression and new erosion detected across study period; change in (C) mean erosion volume; (D) total erosion volume; (E) erosion width; (F) erosion depth and (G) marginal osteosclerosis per patient.Disclosure of Interests:Ho SO: None declared, Isaac T. Cheng: None declared, Sze-Lok Lau: None declared, Evelyn Chow: None declared, Tommy Lam: None declared, Vivian W Hung: None declared, Edmund Li: None declared, James F Griffith: None declared, Vivian WY Lee: None declared, Lin Shi: None declared, Junbin Huang: None declared, Yan Kitty Kwok: None declared, Isaac C Yim: None declared, Tena K. Li: None declared, Vincent Lo: None declared, Jolly M Lee: None declared, Jack Jock Wai Lee: None declared, Ling Qin: None declared, Lai-Shan Tam Grant/research support from: Grants from Novartis and Pfizer

Children's school readiness is important to discuss because learning loss is an obstacle in preparing early childhood to enter elementary school. This study aims to look at parents' perceptions of their children's readiness for school during and after the COVID-19 pandemic. This study uses a quantitative descriptive survey research design to collect measurable data for statistical analysis from a population sample. The results show that preparing children for school during and after the COVID-19 pandemic is very different from the usual practice. Parents are required to provide appropriate stimulation to children at home to replace the role of teachers at school and restore the motivation and willingness of children to enter elementary school. The perception of parents is certainly very influential on the stimulation that will be given to children. Keywords: early childhood education, parents’ perceptions, school readiness References: Alexander, K. L., Entwisle, D. R., & Olson, L. S. (2007). Lasting Consequences of the Summer Learning Gap. American Sociological Review, 72(2), 167–180. https://doi.org/10.1177/000312240707200202 Araújo, L. A. de, Veloso, C. F., Souza, M. de C., Azevedo, J. M. C. de, & Tarro, G. (2021). The potential impact of the COVID-19 pandemic on child growth and development: A systematic review. Jornal de Pediatria, 97(4), 369–377. https://doi.org/10.1016/j.jped.2020.08.008 Atkinsonová, R. L., Atkinson, R. C., SMITH, E. E., Herman, E., Bem, D. J., & Petržela, M. (1995). Psychologies. Victoria Publishing. https://books.google.co.id/books?id=Tj9OAAAACAAJ Bao, X., Qu, H., Zhang, R., & Hogan, T. P. (2020). Modeling Reading Ability Gain in Kindergarten Children during COVID-19 School Closures. International Journal of Environmental Research and Public Health, 17(17). https://doi.org/10.3390/ijerph17176371 Benner, A. D., & Mistry, R. S. (2020). Child Development During the COVID-19 Pandemic Through a Life Course Theory Lens. Child Development Perspectives, 14(4), 236–243. https://doi.org/10.1111/cdep.12387 Brown, S. M., Doom, J. R., Lechuga-Peña, S., Watamura, S. E., & Koppels, T. (2020). Stress and parenting during the global COVID-19 pandemic. Child Abuse & Neglect, 110, 104699. https://doi.org/10.1016/j.chiabu.2020.104699 Colizzi, M., Sironi, E., Antonini, F., Ciceri, M. L., Bovo, C., & Zoccante, L. (2020). Psychosocial and Behavioral Impact of COVID-19 in autism spectrum disorder: An Online Parent Survey. Brain Sciences, 10(6). https://doi.org/10.3390/brainsci10060341 Creswell, J. W. (2015). Educational research: Planning, conducting, and evaluating quantitative and qualitative research (Fifth edition). Pearson. Cushon, J. A., Vu, L. T. H., Janzen, B. L., & Muhajarine, N. (2011). Neighborhood Poverty Impacts Children’s Physical Health and Well-Being Over Time: Evidence from the Early Development Instrument. Early Education and Development, 22(2), 183–205. https://doi.org/10.1080/10409280902915861 Duncan, R. J., Duncan, G. J., Stanley, L., Aguilar, E., & Halfon, N. (2020). The kindergarten Early Development Instrument predicts third grade academic proficiency. Early Childhood Research Quarterly, 53, 287–300. https://doi.org/10.1016/j.ecresq.2020.05.009 Engzell, P., Frey, A., & Verhagen, M. D. (2021). Learning loss due to school closures during the COVID-19 pandemic. Proceedings of the National Academy of Sciences, 118(17), e2022376118. https://doi.org/10.1073/pnas.2022376118 Friedman, M. M., Bowden, V. R., & Jones, E. (2003). Family Nursing: Research, Theory & Practice. Prentice Hall. https://books.google.co.id/books?id=mkBtAAAAMAAJ Gobbi, E., Maltagliati, S., Sarrazin, P., di Fronso, S., Colangelo, A., Cheval, B., Escriva-Boulley, G., Tessier, D., Demirhan, G., Erturan, G., Yüksel, Y., Papaioannou, A., Bertollo, M., & Carraro, A. (2020). Promoting Physical Activity during School Closures Imposed by the First Wave of the COVID-19 Pandemic: Physical Education Teachers’ Behaviors in France, Italy and Turkey. International Journal of Environmental Research and Public Health, 17(24). https://doi.org/10.3390/ijerph17249431 Griffith, A. K. (2020). Parental Burnout and Child Maltreatment During the COVID-19 Pandemic. Journal of Family Violence. https://doi.org/10.1007/s10896-020-00172-2 Hevia, F. J., Vergara-Lope, S., Velásquez-Durán, A., & Calderón, D. (2022). Estimation of the fundamental learning loss and learning poverty related to COVID-19 pandemic in Mexico. International Journal of Educational Development, 88, 102515. https://doi.org/10.1016/j.ijedudev.2021.102515 Jandrić, P. (2020). Postdigital Research in the Time of Covid-19. Postdigital Science and Education, 2(2), 233–238. https://doi.org/10.1007/s42438-020-00113-8 Kuhfeld, M., Tarasawa, B., Johnson, A., Ruzek, E., & Lewis, K. (2020). Initial findings on students’ reading and math achievement and growth. 12. Maldonado, J. E., & De Witte, K. (2022). The effect of school closures on standardised student test outcomes. British Educational Research Journal, 48(1), 49–94. https://doi.org/10.1002/berj.3754 McDowell, K., Jack, A., & Compton, M. (2018). Parent Involvement in Pre-Kindergarten and the Effects on Student Achievement. The Advocate, 23(6). https://doi.org/10.4148/2637-4552.1004 Nevid, J. S. (2012). Psychology: Concepts and Applications. Wadsworth Cengage Learning. https://books.google.co.id/books?id=TpxZXwAACAAJ Skulmowski, A., & Rey, G. D. (2020). COVID-19 as an accelerator for digitalization at a German university: Establishing hybrid campuses in times of crisis. Human Behavior and Emerging Technologies, 2(3), 212–216. https://doi.org/10.1002/hbe2.201 Spinelli, M., Lionetti, F., Pastore, M., & Fasolo, M. (2020). Parents’ Stress and Children’s Psychological Problems in Families Facing the COVID-19 Outbreak in Italy. Frontiers in Psychology, 11, 1713. https://doi.org/10.3389/fpsyg.2020.01713 Yoshikawa, H., Wuermli, A. J., Britto, P. R., Dreyer, B., Leckman, J. F., Lye, S. J., Ponguta, L. A., Richter, L. M., & Stein, A. (2020). Effects of the Global Coronavirus Disease-2019 Pandemic on Early Childhood Development: Short- and Long-Term Risks and Mitigating Program and Policy Actions. The Journal of Pediatrics, 223, 188–193. https://doi.org/10.1016/j.jpeds.2020.05.020

The Covid-19 pandemic had a dangerous impact on early-childhood education, lost learning in almost all aspects of child development. The house-to-house learning, with the name Moving Home Learning Program (MHLP), is an attractive offer as an emergency remote teaching solution. This study aims to describe the application of MHLP designed by early-childhood education institutions during the learning process at home. This study used a qualitative approach with data collection using interviews, observation, and documentation. The respondents involved in the interview were a kindergarten principal and four teachers. The research data were analyzed using the data content analysis. The Findings show that the MHLP has proven to be sufficiently in line with the learning needs of early childhood during the Covid-19 pandemic. Although, the application of the MHLP learning model has limitations such as the distance from the house that is far away, the number of meetings that are only once a week, the number of food and toy sellers passing by, disturbing children's concentration, and the risk of damage to goods at home. The implication of this research can be the basis for evaluating MHLP as an adaptive strategy that requires the attention of related parties, including policy makers, school principals, and teachers for the development of new, more effective online learning models. Keywords: Moving Home Learning Program (MHLP), Children Remote Teaching References:Abdollahi, E., Haworth-Brockman, M., Keynan, Y., Langley, M. J., & Oghadas, S. M. (2020). Simulating the effect of school closure during COVID-19 outbreaks in Ontario , Canada. BMC Medicine, 1–8. https://doi.org/https://doi.org/10.1186/s12916-020-01705-8 Arends, R. I., & Kilcher, A. (2010). Teaching for Student Learning: Becoming an Accomplished Teacher (1st ed.). Routledge. Arysandhi, K. N., & Meitriana, M. A. (2014). Studi Komparatif Motivasi Belajar Siswa pada Mata Pelajaran IPS antara Moving Class dengan Kelas Menetap di SMPN 1 Kerambitan dan SMPN 2 Tabanan Tahun Pelajaran 2013/2014. Ekuitas-Jurnal Pendidikan Ekonomi, 2(1), 30–39. Bawa, P. (2020). Learning in the age of SARS-COV-2 : A quantitative study of learners ’ performance in the age of emergency remote teaching. Computers and Education Open, 1(October), 100016. https://doi.org/10.1016/j.caeo.2020.100016 Bialek, S., Gierke, R., Hughes, M., McNamara, L., Pilishvili, T., & Skoff, T. (2020). Morbidity and mortality weekly report (mmwr) - Coronavirus Disease 2019 in Children — United States, February 12–April 2, 2020. Morbidity and Mortality Weekly Report, 69, 2–6. https://www.cdc.gov/coronavirus/2019-ncov/downloads/pui-form.pdf. Boardman, M. (2003). Changing Times: Changing Challenges for Early Childhood Leaders. Australasian Journal of Early Childhood, 28(2), 20–26. https://doi.org/10.1177/183693910302800205 Bronfenbrenner, U. (1979). The ecology of human development (1st ed.). Harvard University Press. Chen, Y. T. (2020). An investigation of young children’s science and aesthetic learning through a science aesthetic thematic curriculum: A mixed-methods study. Australasian Journal of Early Childhood, 45(2), 127–141. https://doi.org/10.1177/1836939120918503 Choi, N., & Jung, H. (2020). Temperament and Home Environment Characteristics as Predictors of Young Children ’ s Learning Motivation. Early Childhood Education Journal, 1994. https://doi.org/10.1007/s10643-020-01019-7 Counselman, K. P., & Jones, E. (2001). Distance learning in early childhood teacher education: The experience of Pacific Oaks College. Journal of Early Childhood Teacher Education, 22(4), 225–230. https://doi.org/10.1080/1090102010220402 Daniel, S. J. (2020). Education and the COVID-19 pandemic. PROSPECTS, 6. https://doi.org/10.1007/s11125-020-09464-3 Dick, W., Carey, L., & Carey, J. O. (2015). The Systematic Design of Instruction (8th ed.). Pearson. Diningrat, S. W. M., Nindya, M. A., & Salwa. (2020). Cakrawala Pendidikan ,. Cakrawala Pendidikan, 39(3), 705–719. https://doi.org/10.21831/cp.v39i3.32304 Dong, C., Cao, S., & Li, H. (2020). Young children’s online learning during COVID-19 pandemic: Chinese parents’ beliefs and attitudes. Children and Youth Services Review, 118(June), 105440. https://doi.org/10.1016/j.childyouth.2020.105440 Dong, Y., Dong, Y., Mo, X., Hu, Y., Qi, X., Jiang, F., Jiang, Z., Jiang, Z., Tong, S., Tong, S., & Tong, S. (2020). Epidemiology of COVID-19 among children in China. Pediatrics, 145(6). https://doi.org/10.1542/peds.2020-0702 Eliza, D. (2013). Penerapan Model Pembelajaran Kontekstual Learning (CTL) Berbasis Centra di Taman Kanak-Kanak. Pedagogi: Jurnal Ilmiah Ilmu Pendidikan, XIII(2), 93–106. Fadlilah, azizah nurul. (2021). Jurnal Obsesi : Jurnal Pendidikan Anak Usia Dini Strategi Menghidupkan Motivasi Belajar Anak Usia Dini Selama Pandemi COVID-19 melalui Publikasi Abstrak. Jurnal Obsesi : Jurnal Pendidikan Anak Usia Dini, 5(1), 373–384. https://doi.org/10.31004/obsesi.v5i1.548 Fenech, M. (2013). Quality early childhood education for my child or for all children?: Parents as activists for equitable, high-quality early childhood education in Australia. Australian Journal of Early Childhood, 38(4), 92–98. https://doi.org/10.1177/183693911303800413 Gibson, M. (2013). “I want to educate school-age children”: Producing early childhood teacher professional identities. Contemporary Issues in Early Childhood, 14(2), 127–137. https://doi.org/10.2304/ciec.2013.14.2.127 Hamzah, N. (2016). Pelaksanaan Pembelajaran BCCT Bagi Anak Usia Dini ; Study Pelaksanaan BCCT Di Tk Islam Mujahidin Pontianak. At-Turats: Jurnal Pemikiran Pendidikan Islama, 10(2), 119–131. Hasan, M. S., & Saputri, D. E. (2020). Pembelajaran PAI Berbasis Moving Class di SMP Negeri 1 Gudo Jombang. Attaqwa: Jurnal Ilmu Pendidikan Islam, 16(September), 113–125. Hew, K. F., Jia, C., Gonda, D. E., & Bai, S. (2020). Transitioning to the “new normal” of learning in unpredictable times: pedagogical practices and learning performance in fully online flipped classrooms. International Journal of Educational Technology in Higher Education, 17(1). https://doi.org/10.1186/s41239-020-00234-x Hodges, C. B., Moore, S., Lockee, B., Trust, T., & Bond, A. (2020). The Difference Between Emergency Remote Teaching and Online Learning. Educase Review. Hussein, E., Daoud, S., Alrabaiah, H., & Badawi, R. (2020). Children and Youth Services Review Exploring undergraduate students ’ attitudes towards emergency online learning during COVID-19 : A case from the UAE. Children and Youth Services Review, 1–7. https://doi.org/10.1016/j.childyouth.2020.105699 Işıkoğlu, N., Ero, A., Atan, A., & Aytekin, S. (2021). A qualitative case study about overuse of digital play at home. Current Psychology. https://doi.org/https://doi.org/10.1007/s12144-021-01442-y A Kilgallon, P., Maloney, C., & Lock, G. (2008). Early childhood teachers coping with educational change. Australian Journal of Early Childhood, 33(1), 23–29. https://doi.org/10.1177/183693910803300105 Kim, J. (2020). Learning and Teaching Online During Covid ‑ 19 : Experiences of Student Teachers in an Early Childhood Education Practicum. International Journal of Early Childhood, 52(2), 145–158. https://doi.org/10.1007/s13158-020-00272-6 Kurniati, E., Kusumanita, D., Alfaeni, N., & Andriani, F. (2021). Analisis Peran Orang Tua dalam Mendampingi Anak di Masa Abstrak. Jurnal Obsesi : Jurnal Pendidikan Anak Usia Dini, 5(1), 241–256. https://doi.org/10.31004/obsesi.v5i1.541 Lopes, H., & Mckay, V. (2020). pandemics : The COVID ‑ 19 experience. International Review of Education, 0123456789. https://doi.org/10.1007/s11159-020-09843-0 Macartney, K., Quinn, H. E., Pillsbury, A. J., Koirala, A., Deng, L., Winkler, N., Katelaris, A. L., & Sullivan, M. V. N. O. (2020). Articles Transmission of SARS-CoV-2 in Australian educational settings : a prospective cohort study. Lancet Child Adolesc Health 2020, 4642(20), 1–10. https://doi.org/10.1016/S2352-4642(20)30251-0 Marina, Indrawati, H., & Suarman. (2019). Application of Moving Class Learning Models and Teacher Pedagogical Competence on Learning Motivation and Student Learning Discipline. Journal of Educational Sciences, 3(1), 72–83. https://doi.org/doi.org/10.31258/jes.3.1.p.72-83 McLean, K., Edwards, S., & Mantilla, A. (2020). A review of community playgroup participation. Australasian Journal of Early Childhood, 45(2), 155–169. https://doi.org/10.1177/1836939120918484 Muhdi, Nurkolis, & Yuliejantiningsih, Y. (2020). The Implementation of Online Learning in Early Childhood Education During the Covid-19 Pandemic. Jurnal Pendidikan Usia Dini, 14(2), 248–261. https://doi.org/https://doi.org/10.21009/JPUD.142.04 Panovska-griffiths, J., Kerr, C. C., Stuart, R. M., Mistry, D., Klein, D. J., Viner, R. M., & Bonell, C. (2020). Articles Determining the optimal strategy for reopening schools , the impact of test and trace interventions , and the risk of occurrence of a second COVID-19 epidemic wave in the UK : a modelling study. The Lancet Child and Adolescent Health, 4642(20), 1–11. https://doi.org/10.1016/S2352-4642(20)30250-9 Piquero, A. R., Riddell, J. R., Bishopp, S. A., Narvey, C., Reid, J. A., & Piquero, N. L. (2020). Staying Home , Staying Safe ? A Short-Term Analysis of COVID-19 on Dallas Domestic Violence. American Journal of Criminal Justice, 601–635. https://doi.org/https://doi.org/10.1007/s12103-020-09531-7 Pramling, I., Judith, S., Elin, T. W., & Ødegaard, E. (2020). The Coronavirus Pandemic and Lessons Learned in Preschools in Norway , Sweden and the United States : OMEP Policy Forum. International Journal of Early Childhood, 0123456789. https://doi.org/10.1007/s13158-020-00267-3 Pribadi, H., & Harjati, P. (2013). Analisis Pembelajaran Fisika dalam Sistem Moving Class di SMP Negeri 1 Pekalongan Lampung Timur Tahun Pelajaran 2012/2013. JPF, 32–41. Project Tommorow & Blackboard. (2017). Trends in Digital Learning: Building teachers’ capacity and competency to create new learning experiences for students. https://tomorrow.org/speakup/speak-up-2016-trends-digital-learning-june-2017.html Rahiem, M. D. H. (2020). The Emergency Remote Learning Experience of University Students in Indonesia amidst the COVID-19 Crisis. International Journal of Learning, Teaching and Educational Research, 19(6), 1–26. http://orcid.org/0000-0002-5618-2486%0AAbstract. Ramdhani, M. T. (2016). Model Pelaksanaan Pembelajaran Pendidikan Agama Islam dengan Sistem Moving Class dalam Meningkatkan Motivasi dan Prestasi Belajar Siswa SMP IT Sahabat Alam. Anterior Jurnal, 15(2), 212–221. Reigeluth, C. M., Beatty, B. J., & Myers, R. D. (2017). Instructional-Design Theories and Models (R. D. Myers (Ed.); IV). Routledge. Sangsawang, T. (2020). Indonesian Journal of Science & Technology An Instructional Design for Online Learning in Vocational Education according to a Self-Regulated Learning Framework for Problem Solving during the CoViD-19 Crisis. 5. Schmerse, D., Anders, Y., Wieduwilt, N., & Tietze, W. (2018). Differential effects of home and preschool learning environments on early language development. British Educational Research Journal, 44(2), 338–357. https://doi.org/10.1002/berj.3332 Schreier, M. (2013). Qualitative Content Analysis (First Edit). SAGE Publications. Shisley, S. (2020). Emergency Remote Learning Compared to Online Learning. Learning Solution. https://learningsolutionsmag.com/articles/emergency-remote-learning-compared-to-online-learning Son, S., & Morrison, F. J. (2010). The Nature and Impact of Changes in Home Learning Environment on Development of Language and Academic Skills in Preschool Children. 46(5), 1103–1118. https://doi.org/10.1037/a0020065 Stephen, C., Ellis, J., & Martlew, J. (2010). Taking active learning into the primary school: A matter of new practices? International Journal of Early Years Education, 18(4), 315–329. https://doi.org/10.1080/09669760.2010.531916 Sudrajat, C. J., Agustin, M., Kurniati, L., & Karsa, D. (2021). Strategi Kepala TK dalam Meningkatkan Mutu Pendidikan pada Masa Pandemi Covid 19 Abstrak. Jurnal Obsesi : Jurnal Pendidikan Anak Usia Dini, 5(1), 508–520. https://doi.org/10.31004/obsesi.v5i1.582 Sumindar, A., & Wahyu, L. (2012). Model Pembelajaran Moving Class Mata Pelajaran Seni Budaya dan Implikasinya terhadap Kemandirian Siswa (Kajian Kasus) di SMA Karangturi Semarang. Catharsis: Journal of Arts Education, 1(2), 21. Supriatna, R., Hafidhuddin, D., & Syafri, U. A. (2018). Model Pembelajaran Beyond Center and Circle Time (BCCT) Berbasis Q.S Lukman Ayat 12-19. Tawazun: Jurnal Pendidikan Islam, 11(2), 1–11. Syarah, E. S. (2020). Understanding Teacher ’ s Perspectives in Media Literacy Education as an Empowerment Instrument of Blended Learning in Early Childhood Classroom. Jurnal Pendidikan Usia Dini, 14(2), 202–214. https://doi.org/https://doi.org/10.21009/JPUD.142.01 Tang, Y., & Hew, K. F. (2020). Does mobile instant messaging facilitate social presence in online communication? A two-stage study of higher education students. International Journal of Educational Technology in Higher Education, 17(1). https://doi.org/10.1186/s41239-020-00188-0 Thompson, M. (2019). Early Childhood Pedagogy in a Socio ‑ cultural Medley in Ghana : Case Studies in Kindergarten. International Journal of Early Childhood, 51(2), 177–192. https://doi.org/10.1007/s13158-019-00242-7 Togher, M., & Fenech, M. (2020). Ongoing quality improvement in the context of the National Quality Framework: Exploring the perspectives of educators in ‘Working Towards’ services. Australasian Journal of Early Childhood, 45(3), 241–253. https://doi.org/10.1177/1836939120936003 UNESCO. (2020). UNESCO’s support: Educational response to COVID-19. Unesco. https://en.unesco.org/covid19/educationresponse/support Vygotsky, L. S. (1978). Mind in Society: The Development of Higher Psychological Processes. Harvard University Press. Wiresti, R. D. (2021). Analisis Dampak Work From Home pada Anak Usia Dini di Masa Pandemi Covid-19. Jurnal Obsesi : Jurnal Pendidikan Anak Usia Dini, 5(1), 641–653. https://doi.org/10.31004/obsesi.v5i1.563 Wiwatowski, M., Page, J., & Young, S. (2020). Examining early childhood teachers’ attitudes and responses to superhero play. Australasian Journal of Early Childhood, 45(2), 170–182. https://doi.org/10.1177/1836939120918486 Yin, R. K. (2018). Case Study Research and Applications Design and Methods (Eliza Wells (Ed.); Sixth Edit). SAGE Publications. Yoshikawa, H., Wuermli, A. J., Britto, P. R., Dreyer, B., Leckman, J. F., Lye, S. J., Ponguta, L. A., Richter, L. M., & Stein, A. (2020). Effects of the Global Coronavirus Disease-2019 Pandemic on Early Childhood Development: Short- and Long-Term Risks and Mitigating Program and Policy Actions. The Journal of Pediatrics, 223(1), 188–193. https://doi.org/10.1016/j.jpeds.2020.05.020 Zhu, X., & Liu, J. (2020). Education in and After Covid-19 : Immediate Responses and Long-Term Visions. Postdigital Science and Education. https://doi.org/https://doi.org/10.1007/s42438-020-00126-3

-Leslie G. Desmangles, Joan Dayan, Haiti, history, and the Gods. Berkeley: University of California Press, 1995. xxiii + 339 pp.-Barry Chevannes, James T. Houk, Spirits, blood, and drums: The Orisha religion in Trinidad. Philadelphia: Temple University Press, 1995. xvi + 238 pp.-Barry Chevannes, Walter F. Pitts, Jr., Old ship of Zion: The Afro-Baptist ritual in the African Diaspora. New York: Oxford University Press, 1993. xvi + 199 pp.-Robert J. Stewart, Lewin L. Williams, Caribbean theology. New York: Peter Lang, 1994. xiii + 231 pp.-Robert J. Stewart, Barry Chevannes, Rastafari and other African-Caribbean worldviews. London: Macmillan, 1995. xxv + 282 pp.-Michael Aceto, Maureen Warner-Lewis, Yoruba songs of Trinidad. London: Karnak House, 1994. 158 pp.''Trinidad Yoruba: From mother tongue to memory. Tuscaloosa: University of Alabama Press, 1996. xviii + 279 pp.-Erika Bourguignon, Nicola H. Götz, Obeah - Hexerei in der Karibik - zwischen Macht und Ohnmacht. Frankfurt am Main: Peter Lang, 1995. 256 pp.-John Murphy, Hernando Calvo Ospina, Salsa! Havana heat: Bronx Beat. London: Latin America Bureau, 1995. viii + 151 pp.-Donald R. Hill, Stephen Stuempfle, The steelband movement: The forging of a national art in Trinidad and Tobago. Philadelphia: University of Pennsylvania Press, 1995. xx + 289 pp.-Hilary McD. Beckles, Jay R. Mandle ,Caribbean Hoops: The development of West Indian basketball. Langhorne PA: Gordon and Breach, 1994. ix + 121 pp., Joan D. Mandle (eds)-Edmund Burke, III, Lewis R. Gordon ,Fanon: A critical reader. Oxford: Blackwell, 1996. xxi + 344 pp., T. Denean Sharpley-Whiting, Renée T. White (eds)-Keith Alan Sprouse, Ikenna Dieke, The primordial image: African, Afro-American, and Caribbean Mythopoetic text. New York: Peter Lang, 1993. xiv + 434 pp.-Keith Alan Sprouse, Wimal Dissanayake ,Self and colonial desire: Travel writings of V.S. Naipaul. New York : Peter Lang, 1993. vii + 160 pp., Carmen Wickramagamage (eds)-Yannick Tarrieu, Moira Ferguson, Jamaica Kincaid: Where the land meets the body: Charlottesville: University Press of Virginia, 1994. xiii + 205 pp.-Neil L. Whitehead, Vera Lawrence Hyatt ,Race, discourse, and the origin of the Americas: A new world view. Washington DC: Smithsonian Institution Press, 1995. xiii + 302 pp., Rex Nettleford (eds)-Neil L. Whitehead, Patricia Seed, Ceremonies of possession in Europe's conquest of the new world, 1492-1640. Cambridge: Cambridge University Press, 1995. viii + 199 pp.-Livio Sansone, Michiel Baud ,Etnicidad como estrategia en America Latina y en el Caribe. Arij Ouweneel & Patricio Silva. Quito: Ediciones Abya-Yala, 1996. 214 pp., Kees Koonings, Gert Oostindie (eds)-D.C. Griffith, Linda Basch ,Nations unbound: Transnational projects, postcolonial predicaments, and deterritorialized nation-states. Langhorne PA: Gordon and Breach, 1994. vii + 344 pp., Nina Glick Schiller, Cristina Szanton Blanc (eds)-John Stiles, Richard D.E. Burton ,French and West Indian: Martinique, Guadeloupe and French Guiana today. Charlottesville: University Press of Virginia; London: Macmillan Caribbean, 1995. xii + 202 pp., Fred Réno (eds)-Frank F. Taylor, Dennis J. Gayle ,Tourism marketing and management in the Caribbean. New York: Routledge, 1993. xxvi + 270 pp., Jonathan N. Goodrich (eds)-Ivelaw L. Griffith, John La Guerre, Structural adjustment: Public policy and administration in the Caribbean. St. Augustine: School of continuing studies, University of the West Indies, 1994. vii + 258 pp.-Luis Martínez-Fernández, Kelvin A. Santiago-Valles, 'Subject People' and colonial discourses: Economic transformation and social disorder in Puerto Rico, 1898-1947. Albany: State University of New York Press, 1994. xiii + 304 pp.-Alicia Pousada, Bonnie Urciuoli, Exposing prejudice: Puerto Rican experiences of language, race, and class. Boulder: Westview Press, 1996. xiv + 222 pp.-David A.B. Murray, Ian Lumsden, Machos, Maricones, and Gays: Cuba and homosexuality. Philadelphia: Temple University Press, 1996. xxvii + 263 pp.-Robert Fatton, Jr., Georges A. Fauriol, Haitian frustrations: Dilemmas for U.S. policy. Washington DC: Center for strategic & international studies, 1995. xii + 236 pp.-Leni Ashmore Sorensen, David Barry Gaspar ,More than Chattel: Black women and slavery in the Americas. Bloomington: Indiana University Press, 1996. xi + 341 pp., Darlene Clark Hine (eds)-A. Lynn Bolles, Verene Shepherd ,Engendering history: Caribbean women in historical perspective. Kingston: Ian Randle; London: James Currey, 1995. xxii + 406 pp., Bridget Brereton, Barbara Bailey (eds)-Bridget Brereton, Mary Turner, From chattel slaves to wage slaves: The dynamics of labour bargaining in the Americas. Kingston: Ian Randle; Bloomington: Indiana University Press; London: James Currey, 1995. x + 310 pp.-Carl E. Swanson, Duncan Crewe, Yellow Jack and the worm: British Naval administration in the West Indies, 1739-1748. Liverpool: Liverpool University Press, 1993. x + 321 pp.-Jerome Egger, Wim Hoogbergen, Het Kamp van Broos en Kaliko: De geschiedenis van een Afro-Surinaamse familie. Amsterdam: Prometheus, 1996. 213 pp.-Ellen Klinkers, Lila Gobardhan-Rambocus ,De erfenis van de slavernij. Paramaribo: Anton de Kom Universiteit, 1995. 297 pp., Maurits S. Hassankhan, Jerry L. Egger (eds)-Kevin K. Birth, Sylvia Moodie-Kublalsingh, The Cocoa Panyols of Trinidad: An oral record. London & New York: British Academic Press, 1994. xiii + 242 pp.-David R. Watters, C.N. Dubelaar, The Petroglyphs of the Lesser Antilles, the Virgin Islands and Trinidad. Amsterdam: Foundation for scientific research in the Caribbean region, 1995. vii + 492 pp.-Suzannah England, Mitchell W. Marken, Pottery from Spanish shipwrecks, 1500-1800. Gainesville: University Press of Florida, 1994. xvi + 264 pp.

AbstractMe2SN2P2Ph4M(CO)4 complexes (1) (M: 1 a Cr, 1 b Mo, 1 c W) have been synthesized from Me2S(NPPh2)2 and C7H8M(CO)4 . 1a-1c are stable at room temperature, 1 b crystallizes in the space group P21212 with cell constants a = 2486.3(2); b = 1488.8(1); c = 882.0(1) pm.

The reaction of WSCl4 and Me3SiS2CNEt2 in tetrahydrofuran produces a green solid which yields WS(S2)(S2CNEt2)2, WO(S2)(S2CNEt2)2 and syn-W2O2( �-S)2(S2CNEt2)2 upon exposure to oxygen. Crystals of syn-W2O2( �-S)2(S2CNEt2)2 are monoclinic and belong to space group C2/c with a 33.880(4), b 7.012(1), c 18.072(1) � ,β 105.94(1)� and Z 8. Refinement on 2651 data measured with Cu K α: radiation converged at R 0.070. The complex possesses a syn-[W2O2(�-S)2]2+ core with a W-W bond [2.808(1) � ] and two terminal W-O bonds [1.66(2) and 1.68(2) � ]. The W-S(bridging) bond distances are in the range 2.319(5)-2.3346) � Each of the square-pyramidal tungsten atoms is further coordinated to a bidentate dithiocarbamate ligand with W-S bond distances ranging from 2.447(6) to 2.459(5) � .

We quantize the classical gauge theory of N=2 w∞ supergravity and show how the underlying N=2 super-w∞ algebra gets deformed into an N=2 super-W∞ algebra. Both algebras contain the N=2 super-Virasoro algebra as a subalgebra. We discuss how one can extract from these results information about quantum N=2 WN supergravity theories containing a finite number of higher-spin symmetries with superspin s≤N. As an example we discuss the case of quantum N=2 W3 supergravity.

AbstractWe consider the family of Hecke triangle groups $$ \Gamma _{w} = \langle S, T_w\rangle $$ Γ w = ⟨ S , T w ⟩ generated by the Möbius transformations $$ S : z\mapsto -1/z $$ S : z ↦ - 1 / z and $$ T_{w} : z \mapsto z+w $$ T w : z ↦ z + w with $$ w > 2.$$ w > 2 . In this case, the corresponding hyperbolic quotient $$ \Gamma _{w}\backslash {\mathbb {H}}^2 $$ Γ w \ H 2 is an infinite-area orbifold. Moreover, the limit set of $$ \Gamma _w $$ Γ w is a Cantor-like fractal whose Hausdorff dimension we denote by $$ \delta (w). $$ δ ( w ) . The first result of this paper asserts that the twisted Selberg zeta function $$ Z_{\Gamma _{ w}}(s, \rho ) $$ Z Γ w ( s , ρ ) , where $$ \rho : \Gamma _{w} \rightarrow \mathrm {U}(V) $$ ρ : Γ w → U ( V ) is an arbitrary finite-dimensional unitary representation, can be realized as the Fredholm determinant of a Mayer-type transfer operator. This result has a number of applications. We study the distribution of the zeros in the half-plane $$\mathrm {Re}(s) > \frac{1}{2}$$ Re ( s ) > 1 2 of the Selberg zeta function of a special family of subgroups $$( \Gamma _w^N )_{N\in {\mathbb {N}}} $$ ( Γ w N ) N ∈ N of $$\Gamma _w$$ Γ w . These zeros correspond to the eigenvalues of the Laplacian on the associated hyperbolic surfaces $$X_w^N = \Gamma _w^N \backslash {\mathbb {H}}^2$$ X w N = Γ w N \ H 2 . We show that the classical Selberg zeta function $$Z_{\Gamma _w}(s)$$ Z Γ w ( s ) can be approximated by determinants of finite matrices whose entries are explicitly given in terms of the Riemann zeta function. Moreover, we prove an asymptotic expansion for the Hausdorff dimension $$\delta (w)$$ δ ( w ) as $$w\rightarrow \infty $$ w → ∞ .

AbstractWe consider the family of Hecke triangle groups $$ \Gamma _{w} = \langle S, T_w\rangle $$ Γ w = ⟨ S , T w ⟩ generated by the Möbius transformations $$ S : z\mapsto -1/z $$ S : z ↦ - 1 / z and $$ T_{w} : z \mapsto z+w $$ T w : z ↦ z + w with $$ w > 2.$$ w > 2 . In this case, the corresponding hyperbolic quotient $$ \Gamma _{w}\backslash {\mathbb {H}}^2 $$ Γ w \ H 2 is an infinite-area orbifold. Moreover, the limit set of $$ \Gamma _w $$ Γ w is a Cantor-like fractal whose Hausdorff dimension we denote by $$ \delta (w). $$ δ ( w ) . The first result of this paper asserts that the twisted Selberg zeta function $$ Z_{\Gamma _{ w}}(s, \rho ) $$ Z Γ w ( s , ρ ) , where $$ \rho : \Gamma _{w} \rightarrow \mathrm {U}(V) $$ ρ : Γ w → U ( V ) is an arbitrary finite-dimensional unitary representation, can be realized as the Fredholm determinant of a Mayer-type transfer operator. This result has a number of applications. We study the distribution of the zeros in the half-plane $$\mathrm {Re}(s) > \frac{1}{2}$$ Re ( s ) > 1 2 of the Selberg zeta function of a special family of subgroups $$( \Gamma _w^N )_{N\in {\mathbb {N}}} $$ ( Γ w N ) N ∈ N of $$\Gamma _w$$ Γ w . These zeros correspond to the eigenvalues of the Laplacian on the associated hyperbolic surfaces $$X_w^N = \Gamma _w^N \backslash {\mathbb {H}}^2$$ X w N = Γ w N \ H 2 . We show that the classical Selberg zeta function $$Z_{\Gamma _w}(s)$$ Z Γ w ( s ) can be approximated by determinants of finite matrices whose entries are explicitly given in terms of the Riemann zeta function. Moreover, we prove an asymptotic expansion for the Hausdorff dimension $$\delta (w)$$ δ ( w ) as $$w\rightarrow \infty $$ w → ∞ .

AbstractWe show a kind of Obata-type theorem on a compact Einstein n-manifold $$(W, \bar{g})$$ ( W , g ¯ ) with smooth boundary $$\partial W$$ ∂ W . Assume that the boundary $$\partial W$$ ∂ W is minimal in $$(W, \bar{g})$$ ( W , g ¯ ) . If $$(\partial W, \bar{g}|_{\partial W})$$ ( ∂ W , g ¯ | ∂ W ) is not conformally diffeomorphic to $$(S^{n-1}, g_S)$$ ( S n - 1 , g S ) , then for any Einstein metric $$\check{g} \in [\bar{g}]$$ g ˇ ∈ [ g ¯ ] with the minimal boundary condition, we have that, up to rescaling, $$\check{g} = \bar{g}$$ g ˇ = g ¯ . Here, $$g_S$$ g S and $$[\bar{g}]$$ [ g ¯ ] denote respectively the standard round metric on the $$(n-1)$$ ( n - 1 ) -sphere $$S^{n-1}$$ S n - 1 and the conformal class of $$\bar{g}$$ g ¯ . Moreover, if we assume that $$\partial W \subset (W, \bar{g})$$ ∂ W ⊂ ( W , g ¯ ) is totally geodesic, we also show a Gursky-Han type inequality for the relative Yamabe constant of $$(W, \partial W, [\bar{g}])$$ ( W , ∂ W , [ g ¯ ] ) .

In this paper, the local density \((l d)\) and the local weak density \((l w d)\) in the space of permutation degree as well as the cardinal and topological properties of Hattori spaces are studied. In other words, we study the properties of the functor of permutation degree \(S P^{n}\) and the subfunctor of permutation degree \(S P_{G}^{n}\), \(P\) is the cardinal number of topological spaces. Let \(X\) be an infinite \(T_{1}\)-space. We prove that the following propositions hold.(1) Let \(Y^{n} \subset X^{n}\); (A) if \(d\, \left(Y^{n} \right)=d\, \left(X^{n} \right)\), then \(d\, \left(S P^{n} Y\right)=d\, \left(SP^{n} X\right)\); (B) if \(l w d\, \left(Y^{n} \right)=l w d\, \left(X^{n} \right)\), then \(l w d\, \left(S P^{n} Y\right)=l w d\, \left(S P^{n} X\right)\). (2) Let \(Y\subset X\); (A) if \(l d \,(Y)=l d \,(X)\), then \(l d\, \left(S P^{n} Y\right)=l d\, \left(S P^{n} X\right)\); (B) if \(w d \,(Y)=w d \,(X)\), then \(w d\, \left(S P^{n} Y\right)=w d\, \left(S P^{n} X\right)\).(3) Let \(n\) be a positive integer, and let \(G\) be a subgroup of the permutation group \(S_{n}\). If \(X\) is a locally compact \(T_{1}\)-space, then \(S P^{n} X, \, S P_{G}^{n} X\), and \(\exp _{n} X\) are \(k\)-spaces.(4) Let \(n\) be a positive integer, and let \(G\) be a subgroup of the permutation group \(S_{n}\). If \(X\) is an infinite \(T_{1}\)-space, then \(n \,\pi \,w \left(X\right)=n \, \pi \,w \left(S P^{n} X \right)=n \,\pi \,w \left(S P_{G}^{n} X \right)=n \,\pi \,w \left(\exp _{n} X \right)\).We also have studied that the functors \(SP^{n},\) \(SP_{G}^{n} ,\) and \(\exp _{n} \) preserve any \(k\)-space. The functors \(SP^{2}\) and \(SP_{G}^{3}\) do not preserve Hattori spaces on the real line. Besides, it is proved that the density of an infinite \(T_{1}\)-space \(X\) coincides with the densities of the spaces \(X^{n}\), \(\,S P^{n} X\), and \(\exp _{n} X\). It is also shown that the weak density of an infinite \(T_{1}\)-space \(X\) coincides with the weak densities of the spaces \(X^{n}\), \(\,S P^{n} X\), and \(\exp _{n} X\).

BackgroundThe majority of patients with pancreatic ductal adenocarcinoma (PDAC) fail to derive any durable responses from single agent immune checkpoint blockade therapy. This refractory state originates from PDAC's unique tumor microenvironment that is densely populated by immunosuppressive myeloid cells while excluding most antitumor CD8 T cells.1 In addition, PDAC is highly hypoxic and exhibits poor vascularity, both qualities which further limit antitumor immunity.2 3 We showed that the hypoxia-activated prodrug TH-302 (Evofosfamide) potentiates immunotherapy responses.4 Mechanistically, TH-302 decreases intratumoral hypoxia and initiates normalization of the tumor vasculature. While TH-302 facilitates a cellular remodeling process that diminishes tumor hypoxia, the nature of the vascular remodeling involved remains unknown, as do the downstream consequences for the composition of the tumor microenvironment and responsiveness to immunotherapy. We hypothesized that anti-angiogenic therapy and Evofosfamide might cooperate to normalize tumor vasculature and diminish hypoxia.MethodsTH-302 and a vascular endothelial growth factor receptor-2 (VEGFR-2) blocking antibody were used to treat several syngeneic murine models, including orthotopic pancreatic cancer and a transplantable model of prostate cancer. Immunofluorescence and flow cytometry were used to assess intratumoral hypoxia, vessel normalization, and tumor immune infiltrate.ResultsWe find that anti-VEGFR-2 (DC101) in combination with TH-302 demonstrates a cooperative benefit to combat both orthotopically implanted pancreatic cancer and transplantable prostate cancer. Combination therapy reduces intratumoral hypoxia, leads to pruning of the tumor vasculature, and increases the infiltration of endothelial cells into hypoxic regions. Across models, the combination of DC101 and TH-302 significantly enhance CD8 T cell function and limits their exhausted state. At the same time, tumor associated macrophages exhibit decreased expression of M2-like features. Similar to other anti-angiogenic therapies, combination DC101 and TH-302 leads to an increased frequency of PD-L1 expressing cells. Concurrent anti-PD-1 failed to provide any additional therapeutic benefit, which in part may be due poor CD8 T cell infiltration. Instead, we find that CD40 agonist therapy is improved when combined with TH-302 and DC101.ConclusionsTH-302 and DC101 utilize unique yet complementary mechanisms to improve the survival of mice challenged with pancreatic or prostate tumors. This combination relieves hypoxia and simultaneously reinvigorates T cell function and reduces macrophage mediated immunosuppression. In this setting, CD40 agonist therapy provides an additive benefit in prolonging mouse survival. Put together, these data indicate that targeted hypoxia reduction with anti-angiogenic therapy remodels the tumor microenvironment and enhances immunotherapy responses in PDAC.ReferencesBear AS, Vonderheide RH, O'Hara MH. Challenges and opportunities for pancreatic cancer immunotherapy. Cancer Cell. 2020;38(6):788–802. doi: 10.1016/j.ccell.2020.08.004. Epub 2020 Sep 17. PMID: 32946773; PMCID: PMC7738380.Koong AC, Mehta VK, Le QT, Fisher GA, Terris DJ, Brown JM, Bastidas AJ, Vierra M. Pancreatic tumors show high levels of hypoxia. Int J Radiat Oncol Biol Phys 2000;48(4):919–22. doi: 10.1016/s0360-3016(00)00803-8. PMID: 11072146.Olive KP, Jacobetz MA, Davidson CJ, Gopinathan A, McIntyre D, Honess D, Madhu B, Goldgraben MA, Caldwell ME, Allard D, Frese KK, Denicola G, Feig C, Combs C, Winter SP, Ireland-Zecchini H, Reichelt S, Howat WJ, Chang A, Dhara M, Wang L, Rückert F, Grützmann R, Pilarsky C, Izeradjene K, Hingorani SR, Huang P, Davies SE, Plunkett W, Egorin M, Hruban RH, Whitebread N, McGovern K, Adams J, Iacobuzio-Donahue C, Griffiths J, Tuveson DA. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 2009;324(5933):1457–61. doi: 10.1126/science.1171362. Epub 2009 May 21. PMID: 19460966; PMCID: PMC2998180.Jayaprakash P, Ai M, Liu A, Budhani P, Bartkowiak T, Sheng J, Ager C, Nicholas C, Jaiswal AR, Sun Y, Shah K, Balasubramanyam S, Li N, Wang G, Ning J, Zal A, Zal T, Curran MA. Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy. J Clin Invest 2018;128(11):5137–5149. doi: 10.1172/JCI96268. Epub 2018 Oct 15. PMID: 30188869; PMCID: PMC6205399.

Throughout this paper R represents a commutative ring with identity and all R-modules M are unitary left R-modules. In this work we introduce the notion of S-maximal submodules as a generalization of the class of maximal submodules, where a proper submodule N of an R-module M is called S-maximal, if whenever W is a semi essential submodule of M with N ? W ? M, implies that W = M. Various properties of an S-maximal submodule are considered, and we investigate some relationships between S-maximal submodules and some others related concepts such as almost maximal submodules and semimaximal submodules. Also, we study the behavior of S-maximal submodules in the class of multiplication modules. Farther more we give S-Jacobson radical of rings and modules. .

This paper constructs a series of modules from modular Lie superalgebrasW(0∣n),S(0∣n), andK(n)over a field of prime characteristicp≠2. Cartan subalgebras, maximal vectors of these modular Lie superalgebras, can be solved. With certain properties of the positive root vectors, we obtain that the sufficient conditions of these modules are irreducibleL-modules, whereL=W(0∣n),S(0∣n), andK(n).

[Formula: see text]-invariant conformal field theories admit perturbations preserving integrability and leading to massive quantum field theories. The unitary and crossing-invariant S matrices of such QFTs are explicitly constructed by restricting the SL (n, q)-symmetric solutions of the Yang-Baxter equations when qn+k=1. These scattering theories possess level-rank duality (n↔k).

Toeplitz networks are used as interconnection networks due to their smaller diameter, symmetry, simpler routing, high connectivity, and reliability. The edge metric dimension of a network is recently introduced, and its applications can be seen in several areas including robot navigation, intelligent systems, network designing, and image processing. For a vertex s and an edge g = s 1 s 2 of a connected graph G , the minimum number from distances of s with s 1 and s 2 is called the distance between s and g . If for every two distinct edges s 1 , s 2 ∈ E G , there always exists w 1 ɛ W E ⊆ V G , such that d s 1 , w 1 ≠ d s 2 , w 1 ; then, W E is named as an edge metric generator. The minimum number of vertices in W E is known as the edge metric dimension of G . In this study, we consider four families of Toeplitz networks T n 1,2 , T n 1,3 , T n 1,4 , and T n 1,2,3 and studied their edge metric dimension. We prove that for all n ≥ 4 , e dim T n 1,2 = 4 , for n ≥ 5 , e dim T n 1,3 = 3 , and for n ≥ 6 , e dim T n 1,4 = 3 . We further prove that for all n ≥ 5 , e dim T n 1,2,3 ≤ 6 , and hence, it is bounded.

Mature hedgerows of `Anjou' pear (Pyrus communis L.) trees, planted north(N)-south (S) or east (E)-west (W), were used to study the effect of hedgerow orientation on fruiting and canopy exposure. In 1990, flower bud density tended to be lower on the E-W rows, especially on their N sides. Fruit set (FS) was highest on the S side of E-W rows and lowest on the N side, while the E and W sides of the N-S rows were intermediate. Crop density (CD) had a similar pattern as FS, with more fruit on the S than on the N side of the E-W rows. CD was more evenly distributed between the sides on the N-S hedgerows. Differences in FS and CD between sides were related to different levels of sunlight interception. Light exposure was lowest on the N sides of the E-W rows and highest on the S sides throughout the growing season and especially toward the equinoxes. Increased exposure to the sun on the S and W sides late in the season led to more fruit with solar injury. Fruit from E–W rows were larger and less firm. Accumulated yields over 11 years showed a 21.4% increase in the N-S rows over those of the E-W rows.

The load-bearing capacity of self-lubricating W–S films can be improved by doping with nitrogen or carbon. In this study, the chemical composition, the atomic bonding, the structure, and the surface and cross section morphologies of sputtered W–S–C(N) films were analyzed. The addition of the doping element leads to a progressive broadening of the x-ray diffraction (XRD) peaks indicating a loss of crystallinity. In W–S–N films, amorphous structure could be obtained. In W–S–C films, W–C compounds were detected in conjunction with the hexagonal WS2 phase. For the highest C contents, a nanocomposite structure, including those phases and graphite, was suggested for the film. X-ray photoelectron spectroscopy results showed different types of bonds in the W4f peak in good agreement with the XRD results, i.e., when W–C(N) compounds were indexed W–S, W–C, and W–N bonds are present in the W4f peak. For the highest C content film, the detection of C–C bond in the C1s peak confirmed the formation of graphite.

Secara umum, permukaan dapat dikatakan sebagai bagian dari R3 , dimana untuk setiap titik p di suatu lingkungan tertentu di R3 yang dimisalkan dengan S, terdapat suatu himpunan buka di R2 yang dimisalkan dengan U dan suatu himpunan buka di R3 yang dimisalkan dengan W yang memuat p sedemikian sehingga S ∩W homeomorfik pada U. Selanjutnya, suatu permukaan disebut sebagai permukaan regular apabila terdapat suatu pemetaan x dari U ∈ R2 ke S ∩ W ∈ R3 yang terdiferensial dan pemetaan tersebut memiliki turunan (dx) yang satu-satu untuk setiap titik di U. Untuk lebih memahami apa itu permukaan regular, pada makalah ini akan dijelaskan definisi dari permukaan regular dan apa saja karakteristik dari permukaan regular tersebut khususnya karakteristik dari suatu permukaan regular di R3 .Kata Kunci: Lingkungan, terdiferensial, himpunan buka, pemetaan, homeomorfik, permukaan, permukaan regular

The species Piper petiolatum de Candolle (1866: 161) was first described based on specimens collected by J. D. Hooker and T. Thomson from Khasia hills and by W. Griffith (Kew Distribution numbers 4405 & 4410, these numbers were assigned in 1860’s at Kew before distributing the specimens to different herbaria) from East Bengal (present day Bangladesh – however, the labels on the sheets reveal that the Griffith specimens were actually collected from NE India, which is discussed below). Three years later, in A.P. de Candolle’s Prodromus, A.C.P. de Candolle cited these specimens under Chavica petiolata de Candolle (1869: 389), but did not mention his earlier publication of Piper petiolatum nor was the name listed it in the ‘Species e Pipere exclusae’. Eventually, Hooker in Flora of British India (1886: 84) also overlooked that this species name was already published under Piper Linnaeus (1753: 28) by A.C.P. de Candolle and transferred Chavica petiolata to Piper and cited his name as the author made the new combination. However, Hooker observed that the Khasian specimens quoted by A.C.P. de Candolle were actually of Piper thomsonii (de Candolle 1869: 389) Hooker (1886: 87), which was described along with Chavica petiolata. The former species is often treated as a synonym of Piper sylvaticum Roxburgh (1820: 158) (e. g. Long, 1984), although as stated by Gilbert and Nianhe (1999) certain discrepancies exist.

AbstractIn this note, we prove that the kernel of the linearized equation around a positive energy solution in ${\mathbb{R}^{n}}$, ${n\geq 3}$, to the problem $-\Delta W-\gamma|x|^{-2}V=|x|^{-s}W^{2^{\star}(s)-1}$ is one-dimensional when $s+\gamma>0$. Here, ${s\in[0,2)}$, ${0\leq\gamma<(n-2)^{2}/4}$ and ${2^{\star}(s)=2(n-s)/(n-2)}$.

We construct higher-spin N=1 superalgebras as extensions of the super-Virasoro algebra containing generators for all spins s≥3/2. We find two distinct classical (Poisson) algebras on the phase superspace. Our results indicate that only one of them can be consistently quantized.

We prove the longstanding physics conjecture that there exists a unique two-parameter ${\mathcal {W}}_{\infty }$-algebra which is freely generated of type ${\mathcal {W}}(2,3,\ldots )$, and generated by the weights $2$ and $3$ fields. Subject to some mild constraints, all vertex algebras of type ${\mathcal {W}}(2,3,\ldots , N)$ for some $N$ can be obtained as quotients of this universal algebra. As an application, we show that for $n\geq 3$, the structure constants for the principal ${\mathcal {W}}$-algebras ${\mathcal {W}}^k({\mathfrak s}{\mathfrak l}_n, f_{\text {prin}})$ are rational functions of $k$ and $n$, and we classify all coincidences among the simple quotients ${\mathcal {W}}_k({\mathfrak s}{\mathfrak l}_n, f_{\text {prin}})$ for $n\geq 2$. We also obtain many new coincidences between ${\mathcal {W}}_k({\mathfrak s}{\mathfrak l}_n, f_{\text {prin}})$ and other vertex algebras of type ${\mathcal {W}}(2,3,\ldots , N)$ which arise as cosets of affine vertex algebras or nonprincipal ${\mathcal {W}}$-algebras.

Let S=⟨a1,…,ap⟩ be a numerical semigroup, let s∈S and let Z(s) be its set of factorizations. The set of lengths is denoted by L(s)={L(x1,⋯,xp)∣(x1,⋯,xp)∈Z(s)}, where L(x1,⋯,xp)=x1+⋯+xp. The following sets can then be defined: W(n)={s∈S∣∃x∈Z(s)suchthatL(x)=n}, ν(n)=⋃s∈W(n)L(s)={l1<l2<⋯<lr} and Δν(n)={l2−l1,…,lr−lr−1}. In this paper, we prove that the function Δν:N→P(N) is almost periodic with period lcm(a1,ap).

Suppose p n be sequence of positive reals. By H w p n , we represent the space of all formal power series ∑ n = 0 ∞ a n z n equipped with ∑ n = 0 ∞ λ a n / n + 1 p n < ∞ , for some λ > 0 . Various topological and geometric behavior of H w p n and the prequasi ideal constructs by s -numbers and H w p n have been considered. The upper bounds for s -numbers of infinite series of the weighted n -th power forward shift operator on H w p n with applications to some entire functions are granted. Moreover, we investigate an extrapolation of Caristi’s fixed point theorem in H w p n .

AbstractA group of subarboreal tropical beetles, the Xystosomi of subtribe Xystosomina new subtribe, is revised and reclassified based on a reevaluation of structural characters. Xystosomi are found in tropical Australia (Queensland) and tropical/subtropical America (Guerrero, México, to Aguas Blancas, Argentina). The largest concentration of species occurs near the equator in the Amazon Basin, but a significant radiation of flightless forms was recently discovered in the northern Andes of Colombia, Ecuador, and Venezuela. Xystosomina also includes the Mioptachyi, which at present is composed of the genera Mioptachys and Inpa.Seventy-six species of Neotropical and Australian Xystosomi are described or re-described, illustrated, or keyed. This assemblage includes 12 classic species, 24 species described in the last 3 decades, and 40 new species, a 6-fold increase since the time of Henry Walter Bates, the last 19th-century entomologist to study this remarkable lineage of carabid beetles. The Xystosomi are now arrayed in five genera: Philipis gen.nov. (type: Tachys trunci Darlington, Australia), Geballusa gen.nov. (type: Xystosomus microtretus Erwin, Costa Rica), Gouleta gen.nov. (type: Bembidion cayennense Dejean, Brazil), Batesiana gen.nov. (type: Xystosomus gruti Bates, Brazil), and Xystosomus Schaum (type: Xystosomus inflatus Schaum, Brazil).The following specific taxa are described as new (type-locality in parentheses): Geballusa rex (Brazil: 06°02′N 050°17′W), oligotreta (Panamá: 08°40′N 079°56′W), nannotreta (Brazil: 02°54′S 059°57′W), Gouleta gentryi (Perú: 12°50′S 069°20′W), Batesiana para (Brazil: 01°22′S 048°20′W), angustia (Perú: 05°08′S 074°45′W), samiria (Perú: 05°08′S 074°45′W), esheje (Perú: 05°08′S 074°45′W), crassa (Perú: 03°15′S 072°55′W), notesheje (Perú: 03°15′S 072°55′W), manusculptilis (Perú: 12°07′S 070°58′W), parapara (Brazil: 02°28′S 046°26′W), am (Perú: 05°08′S 074°45′W), indetecticostis (Ecuador: 00°57′S 077°48′W), nox (Ecuador: 00°57′S 077°48′W), parkeri (Perú: 03°15′S 072°55′W), hamatilis (Ecuador: 01°02′S 077°40′W), notparkeri (Colombia: 00°08′N 075°51′W), pfunorum (Perú: 03°15′S 072°55′W), quadrata (Perú: 03°15′S 072°55′W), protosculptilis (Perú: 12°50′S 069°20′W), misahualli (Ecuador: 01°02′S 077°40′W), depressisculptilis (Ecuador: 01°02′S 077°40′W), irisculptilis (Ecuador: 00°24′S 076°37′W), foveosculptilis (Brazil: 02°28′S 046°26′W), punctisculptilis (Perú: 03°15′S 072°55′W), eugeneae (Perú: 11°56′47″S 071°17′00″W), anchicaya (Colombia: 03°43′N 076°57′W), jefe (Panamá: 09°12′N 079°21′W), exigupunctata (Perú: 05°08′S 074°45′W), rosebudae (Ecuador: 00°57′S 077°48′W), equanegrei (Ecuador: 00°57′S 077°48′W), henryi (Ecuador: 00°28′S 077°53′W), baeza (Ecuador: 00°57′S 077°48′W), huacamayas (Ecuador: 00°28′S 077°53′W), dannyi (Ecuador: 00°57′S 077°48′W), alticola (Colombia: 04°21′S 074°22′W), jacupiranga (Brazil: 24°42′S 048°00′W), chiriboga (Ecuador: 00°15′S 078°44′W), wygo (Colombia: 04°53′N 074°31′W).The following names are resurrected from synonymy for good species: hilaris Bates and belti Bates. Several name combinations were changed as a result of the generic reorganization: Philipis trunci (Darlington), Geballusa microtreta (Erwin), G. polytreta (Erwin), Gouleta notiophiloides (Erwin), G. spangleri (Erwin), G. cayennense (Dejean), Batesiana bisulcifrons (Erwin), B. negrei (Erwin), B. hilaris (Bates), B. belti (Bates), B. ampliata (Bates), B. strigosa (Bates), B. gruti (Bates), B. nigripalpis (Erwin), B. villiersi (Perrault), B. apicisulcata (Erwin), B. iris (Erwin), B. sculpticollis (Bates), B. sulcicostis (Bates), B. anterocostis (Erwin), B. ovatula (Bates), B. grossipunctata (Erwin), B. batesi (Erwin), B. seriata (Erwin), B. sublaevis (Bates), B. aetholia (Erwin), B. parainsularis (Erwin), NEW COMBINATIONS.Results of the Xystosomi character analysis provided impetus for a reanalysis of the classification of the major lineages of the more inclusive group, Bembidiini, to discover where the Xystosomi might belong and, in turn, if our understanding of the Bembidiini itself needed adjustment. These results are implied in Part I, but presented in detail in a separate paper, Part II. Phylogeny and Zoogeography, along with supplemental taxonomic information.

Abstract ‘TAMBel-2’ bell pepper transplants (Capsicum annuum L.) were grown in a greenhouse for 39 days in north–south (N–S) oriented trays. About 69% of the plants had monodirectional (one plane pointing either N–S, E–W, NW–SE, or SW–NE) lateral root patterns, 23% had bidirectional (two planes), and 7% had omnidirectional (all around) root patterns relative to a N–S greenhouse tray orientation. Transplants were planted with cotyledons N–S (parallel to the N–S bed), with cotyledons E–W (perpendicular to the N–S bed), and at random, without regard to orientation. These plants subsequently were cultivated either deeply (9 cm) or shallowly (3 cm) 3, 5, and 7 weeks after transplanting. Transplants planted E–W by cotyledon orientation yielded significantly more early and overall marketable pods in contrast to those planted N–S by cotyledon orientation or at random. Deep cultivation decreased productivity in contrast to shallow cultivation and negated any benefit to E–W cotyledon orientation. Root and cotyledon orientations in field-seeded peppers were determined for ‘Hidalgo’, ‘TAM-Mild Chile-2’, ‘TAMBel-2’, and ‘Grand Rio 66’ peppers ≈2 months after field-seeding. At least 95% of the populations in all cultivars had monodirectional root orientations. Generally, orientations were divided equally among N–S, E–W, NW–SE, and NE–SW directions. Cotyledon orientation highly correlated with root orientation in all cultivars.

AbstractIn the following, we show the strong comparison principle for the fractional p-Laplacian, i.e. we analyze\quad\left\{\begin{aligned} \displaystyle(-\Delta)^{s}_{p}v+q(x)\lvert v\rvert% ^{p-2}v&\displaystyle\geq 0&&\displaystyle\phantom{}\text{in ${D}$},\\ \displaystyle(-\Delta)^{s}_{p}w+q(x)\lvert w\rvert^{p-2}w&\displaystyle\leq 0&% &\displaystyle\phantom{}\text{in ${D}$},\\ \displaystyle v&\displaystyle\geq w&&\displaystyle\phantom{}\text{in ${\mathbb% {R}^{N}}$},\end{aligned}\right.where {s\in(0,1)}, {p>1}, {D\subset\mathbb{R}^{N}} is an open set, and {q\in L^{\infty}(\mathbb{R}^{N})} is a nonnegative function. Under suitable conditions on s, p and some regularity assumptions on v, w, we show that either {v\equiv w} in {\mathbb{R}^{N}} or {v>w} in D. Moreover, we apply this result to analyze the geometry of nonnegative solutions in starshaped rings and in the half space.

Objective To determine which mode and potency of electrocoagulation, using a modern electrosurgical generator, yields the smallest unobstructed area of the Fallopian tubes. Methods In an experimental study, tubes from 48 hysterectomies or tubal ligation were evaluated. Tubes were randomly allocated to one of the following groups: group A) 25 W x 5 seconds (n = 17); group B) 30 W x 5 seconds (n = 17); group C) 35 W x 5 seconds (n = 18), group D) 40 W x 5 seconds (n = 20); group E) 40 W x 5 seconds with visual inspection (blanch, swells, collapse) (n = 16); group F) 50 W x 5 seconds (n = 8). Bipolar electrocoagulation was performed in groups A to E, and monopolar electrocoagulation was performed in group F. Coagulation mode was used in all groups. Digital photomicrography of the transversal histological sections of the isthmic segment of the Fallopian tube were taken, and the median percentage of unobstructed luminal area (mm2) was measured with ImageJ software (ImageJ, National Institutes of Health, Bethesda, MD, USA). The Kruskal-Wallis test or analysis of variance (ANOVA) was used for statistical analysis. Results Ninety-six Fallopian tube sections were analyzed. The smallest median occluded area (%; range) of the Fallopian tube was obtained in the group with 40 W with visual inspection (8.3%; 0.9–40%), followed by the groups 25 W (9.1%; 0–35.9%), 40 W (14.2; 0.9–43.2%), 30 W (14.2; 0.9–49.7%), 35 W (15.1; 3–46.4%) and 50 W (38.2; 3.1–51%). No statistically significant difference was found among groups (p = 0.09, Kruskal-Wallis test). Conclusion The smallest unobstructed area was obtained with power setting at 40 W with visual inspection using a modern electrosurgical generator. However, no statistically significant difference in the unobstructed area was observed among the groups using these different modes and potencies.

Let J R denote the Jacobson radical of a ring R . We say that ring R is strong J-symmetric if, for any a , b , c ∈ R , a b c ∈ J R implies b a c ∈ J R . If ring R is strong J-symmetric, then it is proved that R x / x n is strong J-symmetric for any n ≥ 2 . If R and S are rings and W S R is a R , S -bimodule, E = T R , S , W = R W 0 S = r w 0 s | r ∈ R , w ∈ W , s ∈ S , then it is proved that R and S are J-symmetric if and only if E is J-symmetric. It is also proved that R and S are strong J-symmetric if and only if E is strong J-symmetric.

O segmento de papel e celulose tem posição de destaque na economia do setor florestal brasileiro e mundial. O objetivo deste estudo foi analisar a dinâmica da produção, importação, exportação e consumo aparente de três tipos de papéis (P+W: imprimir e escrever, H+S: uso doméstico e sanitário e N: jornal) no período de 1961 a 2016. Para essa análise foram utilizados dados extraídos do sistema FAOSTAT da FAO. Os resultados encontrados demonstram que nesse período foram produzidas 77 M t de P+W, 24 M t de H+S e 9 M t de N. As importações totalizaram 10 M t, 188 mil t e 12 M t, respectivamente para P+W, H+S e N. As exportações no período foram de 25 M t, 500 mil t e 334 mil t, respectivamente. O consumo aparente foi de 61 M t, 24 M t e 21 M t, respectivamente. O consumo médio per capita desses papéis no período foi de 6,98; 2,58 e 2,57 kg.hab-1. O consumo de H+S deu-se de forma crescente em toda a série temporal, enquanto que para P+W e N foi decrescente, sobretudo a partir de 2010. O Brasil é superavitário em P+W e H+S e deficitário na balança comercial em N. Conclui-se que há uma tendência de queda de consumo em P+W e N e aumento de H+S, essa tendência é verificada na produção, importação e consumo. As exportações de H+S e N ainda são pouco expressivas. Já as importações de P+W e N apresentaram tendência de queda desde 2010.

Пусть $S \subset \mathbb{R}^{n}$ - замкнутое непустое множество такое, что для некоторых $d \in [0,n]$ и $\varepsilon>0$ $d$-вместимость по Хаусдорфу $\mathscr{H}^{d}_{\infty}(S \cap Q(x,r)) \geq \varepsilon r^{d}$ для всех кубов $Q(x,r)$ с центрами в $x \in S$ и длинами ребер $2r \in (0,2]$. Для каждого $p>\max\{1,n-d\}$ мы даем внутреннюю характеризацию пространства следов $W_{p}^{1}(\mathbb{R}^{n})|_{S}$ на множестве $S$ пространства Соболева $W_{p}^{1}(\mathbb{R}^{n})$. Более того, мы доказываем существование ограниченного линейного оператора продолжения $\operatorname{Ext}\colon W_{p}^{1}(\mathbb{R}^{n})|_{S} \to W_{p}^{1}(\mathbb{R}^{n})$, являющегося правым обратным для стандартного оператора следа. Тем самым мы обобщаем соответственно те результаты, которые были получены ранее в случае $p \in (1,n]$ для регулярных по Альфорсу множеств $S$. Библиография: 36 названий.

Abstract Let {m,n} be positive integers and w a multilinear commutator word. Assume that G is a finite group having subgroups {G_{1},\ldots,G_{m}} whose union contains all w-values in G. Assume further that all elements of the subgroups {G_{1},\ldots,G_{m}} are n-Engel in G. It is shown that the verbal subgroup {w(G)} is s-Engel for some {\{m,n,w\}} -bounded number s.