Letteratura scientifica selezionata sul tema "Genome spatial organization"
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Articoli di riviste sul tema "Genome spatial organization"
Parada, L. "Spatial genome organization". Experimental Cell Research 296, n. 1 (15 maggio 2004): 64–70. http://dx.doi.org/10.1016/j.yexcr.2004.03.013.
Testo completoRajarajan, Prashanth, Sergio Espeso Gil, Kristen J. Brennand e Schahram Akbarian. "Spatial genome organization and cognition". Nature Reviews Neuroscience 17, n. 11 (6 ottobre 2016): 681–91. http://dx.doi.org/10.1038/nrn.2016.124.
Testo completoBrickner, Jason. "Genetic and epigenetic control of the spatial organization of the genome". Molecular Biology of the Cell 28, n. 3 (febbraio 2017): 364–69. http://dx.doi.org/10.1091/mbc.e16-03-0149.
Testo completoFinn, Elizabeth H., e Tom Misteli. "Molecular basis and biological function of variability in spatial genome organization". Science 365, n. 6457 (5 settembre 2019): eaaw9498. http://dx.doi.org/10.1126/science.aaw9498.
Testo completoXie, Ting, Liang-Yu Fu, Qing-Yong Yang, Heng Xiong, Hongrui Xu, Bin-Guang Ma e Hong-Yu Zhang. "Spatial features for Escherichia coli genome organization". BMC Genomics 16, n. 1 (2015): 37. http://dx.doi.org/10.1186/s12864-015-1258-1.
Testo completoKim, S. H., P. G. McQueen, M. K. Lichtman, E. M. Shevach, L. A. Parada e T. Misteli. "Spatial genome organization during T-cell differentiation". Cytogenetic and Genome Research 105, n. 2-4 (2004): 292–301. http://dx.doi.org/10.1159/000078201.
Testo completoRamani, Vijay, Jay Shendure e Zhijun Duan. "Understanding Spatial Genome Organization: Methods and Insights". Genomics, Proteomics & Bioinformatics 14, n. 1 (febbraio 2016): 7–20. http://dx.doi.org/10.1016/j.gpb.2016.01.002.
Testo completoBickmore, Wendy A. "The Spatial Organization of the Human Genome". Annual Review of Genomics and Human Genetics 14, n. 1 (31 agosto 2013): 67–84. http://dx.doi.org/10.1146/annurev-genom-091212-153515.
Testo completoPurugganan, Michael D. "Scale-invariant spatial patterns in genome organization". Physics Letters A 175, n. 3-4 (aprile 1993): 252–56. http://dx.doi.org/10.1016/0375-9601(93)90836-o.
Testo completoLlorens-Giralt, Palmira, Carlos Camilleri-Robles, Montserrat Corominas e Paula Climent-Cantó. "Chromatin Organization and Function in Drosophila". Cells 10, n. 9 (8 settembre 2021): 2362. http://dx.doi.org/10.3390/cells10092362.
Testo completoTesi sul tema "Genome spatial organization"
Ben, Zouari Yousra. "The functional and spatial organization of chromatin during Thymocyte development". Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ025.
Testo completoChromosome folding takes place at different hierarchical levels, with various topologies correlated with control of gene expression. Despite the large number of recent studies describing chromatin topologies and their correlations with gene activity, many questions remain, in particular how these topologies are formed and maintained. To understand better the link between epigenetic marks, chromatin topology and transcriptional control, we use CHi-C technique based on the chromosome conformation capture (3C) method. By using two capture strategies targeting two different chromatin structures (chromatin loops and topological domains), we have been able to decipher the chromatin structure associated with thymocyte differentiation and to highlight mechanisms for the transcriptional control of certain genes. Future experiments of the lab will examine mechanisms other than transcription which may influence chromatin architecture, such as differential binding of CTCF, and how these may interplay with transcriptional control and chromatin architecture
Lapendry, Audrey. "Les biais de composition des gènes et de leurs produits établissent un lien entre l'organisation spatiale du génome et celle de la cellule". Electronic Thesis or Diss., Lyon, École normale supérieure, 2023. http://www.theses.fr/2023ENSL0109.
Testo completoGenes are not randomly distributed in the nucleus space, but are organized within more or less dynamical spatial clusters. This genome spatial organization plays a major role in gene expression regulation. Using different types of experimental data, it is shown that genes in spatial proximity to each other share the same nucleotide composition biases, which could in part explain the spatial genome self-organization. In addition, co-localized genes with similar biases have a higher probability of being co-regulated by the same transcription factors. They also produce RNAs that share the same nucleotide composition biases, that are co-regulated by the same RNA-binding proteins. Finally, mRNAs produced by genes that co-localize generate proteins that share the same amino acid composition biases. As a consequence, proteins produced by co-localized genes share the same physicochemical properties and have a higher probability of belonging to the same cellular sub-compartments and to have similar biological functions. Thus, by analyzing compositional biases, as a proxy of the physicochemical properties of genes and their products, it is highlighted a link between the spatial organization of genes in the nucleus and the spatial organization of their products (i.e. proteins) in the cell
Carron, Léopold. "Analyse à haute résolution de la structure spatiale des chromosomes eucaryotes Boost-HiC : Computational enhancement of long-range contacts in chromosomal contact maps Genome supranucleosomal organization and genetic susceptibility to disease". Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS593.
Testo completoGenetic information is encoded in DNA, a huge-size nucleotidic polymer. In order to understand DNA folding mechanisms, an experimental technique is today available that quantifies distal genomic contacts. This high-throughput chromosome conformation capture technique, called Hi-C, reveals 3D chromosome folding in the nucleus. In the recent years, the Hi-C experimental protocol received many improvements through numerous studies for Human, mouse and drosophila genomes. Because most of these studies are performed at poor resolution, I propose bioinformatic methods to analyze these datasets at fine resolution. In order to do this, I present Boost-HiC, a tool that enhanced long-range contacts in Hi-C data. I will then used our extended knowledge to compare 3D folding in different species. This result provides the basis to determine the best method for obtaining genomic compartements from a chromosomal contact map. Finally, I present some other applications of our methodology to study the link between the borders of topologically associating domains and the genomic location of single-nucleotide mutations associated to cancer
Mardaryev, Andrei N., e Michael Y. Fessing. "3D-FISH analysis of the spatial genome organization in skin cells in situ". 2020. http://hdl.handle.net/10454/18511.
Testo completoSpatial genome organization in the cell nucleus plays a crucial role in the control of genome functions. Our knowledge about spatial genome organization is relying on the advances in gene imaging technologies and the biochemical approaches based on the spatial dependent ligation of the genomic regions. Fluorescent in situ hybridization using specific fluorescent DNA and RNA probes in cells and tissues with the spatially preserved nuclear and genome architecture (3D-FISH) provides a powerful tool for the further advancement of our knowledge about genome structure and functions. Here we describe the 3D-FISH protocols allowing for such an analysis in mammalian tissue in situ including in the skin. These protocols include DNA probe amplification and labeling; tissue fixation; preservation and preparation for hybridization; hybridization of the DNA probes with genomic DNA in the tissue; and post-hybridization tissue sample processing.
Bohn, Manfred [Verfasser]. "Modelling of interphase chromosomes : from genome function to spatial organization / put forward by Manfred Bohn". 2010. http://d-nb.info/1002270839/34.
Testo completoMatala, Ilunga Benjamin. "Une correction à l’échelle et progressive des données Hi-C révèlent des principes fondamentaux de l’organisation tridimensionnelle et fonctionnelle du génome". Thèse, 2016. http://hdl.handle.net/1866/18662.
Testo completoOver the last decade, accumulating empirical evidence suggest that, as much as its sequence, a genome spatiotemporal organization is essential to understand it’s biological function. One of the major breakthroughs has been chromosome conformation capture (3C) experiments presenting DNA-DNA contact for whole genomes at unprecedented resolution (5-10kb). Along with genome-wide maps of DNA contacts came genome 3D modelling from experimental 3C data, and even from purely theoretical and biophysical basis. However, the mechanisms underlying the regulation of the genome spatial functional organization are still not well understood. Among other questions, how the regulation and event of nuclear processes such as transcription modulate genome structure or how genome structure affect these in turn is still not fully resolved. Moreover, computational models of S.cerevisae genome have recapitulated the hallmarks at larger scale of its 3D features. In order to contrast genome structural features arising from the event of biochemical and molecular activity, we have develop a method assessing the significance of structural features. The underlying principle is to consider for a given interaction, the two DNA regions put in contact and the distribution of existing interactions between these before assigning significance to the selected interaction. Using this method, we demonstrate that structural features resulting from potential biochemically active processes occur at precise scale on the genome. Our results also highlight that exact nature of the interaction (between vs across chromosomes) is crucial to such events. Finally, we have also found that a large portion of transcription factors have their targeted genes in spatial proximity.
Libri sul tema "Genome spatial organization"
Sexton, Tom, a cura di. Spatial Genome Organization. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2497-5.
Testo completoMekhail, Karim, e Evi Soutoglou, a cura di. Spatial Genome Organization. Frontiers Media SA, 2022. http://dx.doi.org/10.3389/978-2-88974-504-3.
Testo completoSexton, Tom. Spatial Genome Organization: Methods and Protocols. Springer, 2022.
Cerca il testo completoChen, Xiangyang. Woman, Generic Aesthetics, and the Vernacular. University of Illinois Press, 2017. http://dx.doi.org/10.5406/illinois/9780252036613.003.0013.
Testo completoCapitoli di libri sul tema "Genome spatial organization"
Zhang, Liguo, Yu Chen e Andrew S. Belmont. "Measuring Cytological Proximity of Chromosomal Loci to Defined Nuclear Compartments with TSA-seq". In Spatial Genome Organization, 145–86. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2497-5_8.
Testo completoRebouissou, Cosette, Séphora Sallis e Thierry Forné. "Quantitative Chromosome Conformation Capture (3C-qPCR)". In Spatial Genome Organization, 3–13. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2497-5_1.
Testo completoFinn, Elizabeth, Tom Misteli e Gianluca Pegoraro. "High-Throughput DNA FISH (hiFISH)". In Spatial Genome Organization, 245–74. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2497-5_12.
Testo completoMiranda, Mélanie, Daan Noordermeer e Benoit Moindrot. "Detection of Allele-Specific 3D Chromatin Interactions Using High-Resolution In-Nucleus 4C-seq". In Spatial Genome Organization, 15–33. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2497-5_2.
Testo completoZhigulev, Artemy, e Pelin Sahlén. "Targeted Chromosome Conformation Capture (HiCap)". In Spatial Genome Organization, 75–94. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2497-5_5.
Testo completoGrob, Stefan. "Tough Tissue Hi-C". In Spatial Genome Organization, 35–50. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2497-5_3.
Testo completoSeow, Wei Qiang, Poonam Agarwal e Kevin C. Wang. "CLOuD9: CRISPR-Cas9-Mediated Technique for Reversible Manipulation of Chromatin Architecture". In Spatial Genome Organization, 293–309. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2497-5_14.
Testo completoOudelaar, A. Marieke, Damien J. Downes e Jim R. Hughes. "Assessment of Multiway Interactions with Tri-C". In Spatial Genome Organization, 95–112. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2497-5_6.
Testo completoSabate, Thomas, Christophe Zimmer e Edouard Bertrand. "Versatile CRISPR-Based Method for Site-Specific Insertion of Repeat Arrays to Visualize Chromatin Loci in Living Cells". In Spatial Genome Organization, 275–90. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2497-5_13.
Testo completoMaresca, Michela, Ning Qing Liu e Elzo de Wit. "Acute Protein Depletion Strategies to Functionally Dissect the 3D Genome". In Spatial Genome Organization, 311–31. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2497-5_15.
Testo completoAtti di convegni sul tema "Genome spatial organization"
"Search of new type of spatial organization of nucleic acids in human genome". In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-084.
Testo completoFinan, John D., e Farshid Guilak. "Osmotic Stress Affects Nuclear Morphology and Genome Architecture". In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-205759.
Testo completo"Chromatin loops are involved in spatial organization of replication in budding yeast". In Bioinformatics of Genome Regulation and Structure/Systems Biology (BGRS/SB-2022) :. Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences, 2022. http://dx.doi.org/10.18699/sbb-2022-069.
Testo completoAkdemir, Kadir C., e Andrew Futreal. "Abstract 5361: Spatial genome organization as a framework for somatic alterations in human cancer". In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-5361.
Testo completo"Search for a new type of spatial organization of nucleic acids in human genome". In SYSTEMS BIOLOGY AND BIOINFORMATICS (SBB-2020). Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences., 2020. http://dx.doi.org/10.18699/sbb-2020-40.
Testo completoSupper, Jochen, Claas aufm Kampe, Dierk Wanke, Kenneth W. Berendzen, Klaus Harter, Richard Bonneau e Andreas Zell. "Modeling gene regulation and spatial organization of sequence based motifs". In 2008 8th IEEE International Conference on Bioinformatics and BioEngineering (BIBE). IEEE, 2008. http://dx.doi.org/10.1109/bibe.2008.4696696.
Testo completoWen, Shin-Min, e Pen-hsiu Grace Chao. "Spatial Actin Structure Does Not Correlate With Nuclear Organization". In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14167.
Testo completoRapporti di organizzazioni sul tema "Genome spatial organization"
Misteli, Thomas, e Karen Meaburn. Breast Cancer Diagnostics Based on Spatial Genome Organization. Fort Belvoir, VA: Defense Technical Information Center, luglio 2012. http://dx.doi.org/10.21236/ada567356.
Testo completoApplebaum, Shalom W., Lawrence I. Gilbert e Daniel Segal. Biochemical and Molecular Analysis of Juvenile Hormone Synthesis and its Regulation in the Mediterranean Fruit Fly (Ceratitis capitata). United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7570564.bard.
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