Articoli di riviste sul tema "Garden Center of Greater Cleveland"
Segui questo link per vedere altri tipi di pubblicazioni sul tema: Garden Center of Greater Cleveland.
Cita una fonte nei formati APA, MLA, Chicago, Harvard e in molti altri stili
Vedi i top-50 articoli di riviste per l'attività di ricerca sul tema "Garden Center of Greater Cleveland".
Accanto a ogni fonte nell'elenco di riferimenti c'è un pulsante "Aggiungi alla bibliografia". Premilo e genereremo automaticamente la citazione bibliografica dell'opera scelta nello stile citazionale di cui hai bisogno: APA, MLA, Harvard, Chicago, Vancouver ecc.
Puoi anche scaricare il testo completo della pubblicazione scientifica nel formato .pdf e leggere online l'abstract (il sommario) dell'opera se è presente nei metadati.
Vedi gli articoli di riviste di molte aree scientifiche e compila una bibliografia corretta.
1
MacPhail, Ian. "The Cleveland Herbal, Botanical, and Horticultural Collections: A Descriptive Bibliography of Pre-1830 Works from the Libraries of the Holden Arboretum, the Cleveland Medical Library Association, and the Garden Center of Greater Cleveland. Stanley H. Johnston Jr." Papers of the Bibliographical Society of America 87, n. 4 (dicembre 1993): 521–23. http://dx.doi.org/10.1086/pbsa.87.4.24304811.
Testo completo
2
Reeds, Karen. "The Cleveland Herbal, Botanical, and Horticultural Collections: A Descriptive Bibliography of Pre-1830 Works from the Libraries of the Holden Arboretum, the Cleveland Medical Library Association, and the Garden Center of Greater Cleveland. Stanley H. Johnston, Jr." Isis 85, n. 1 (marzo 1994): 198. http://dx.doi.org/10.1086/356805.
Testo completo
3
DOUGLAS, GINA. "JOHNSTON, S.H. Jr, compiler. The Cleveland herbal, botanical and horticultural collection, a descriptive bibliography of pre-1830 works from the libraries of the Holden Arboretum, the Cleveland Medical Library Association, and the garden center of Greater Cleveland. Kent State University Press, Kent: 1992. Pp xviii, 1012; illustrated, one colour plate. Price: £ 76.50. ISBN: 0-87338-433-4." Archives of Natural History 22, n. 2 (giugno 1995): 293. http://dx.doi.org/10.3366/anh.1995.22.2.293a.
Testo completo
4
Thomas, Gelise, Lizzie Bjork, Zina Hempstead e Gulnar Feerasta. "110 Answering the Call for Greater LGBTQ+ Research Inclusivity by Co-Developing A Workshop for Researchers". Journal of Clinical and Translational Science 8, s1 (aprile 2024): 31. http://dx.doi.org/10.1017/cts.2024.108.
Testo completoAbstract (sommario):
OBJECTIVES/GOALS: The objectives of this workshop were to: (1) provide learners with a space to become aware of and discuss the history of the LGBTQ+ community in medical and public health research; (2) apply frameworks for LGBTQ+ inclusivity in research, inspired by lived experience and multimedia; and (3) assess LGBTQ+ research inclusivity best practices. METHODS/STUDY POPULATION: The CTSC provided the LGBT Community Center of Greater Cleveland (Center) with access to academic resources via an affiliate account and insights on the clinical and translational science research process. Members of the CTSC Research Equity, Accessibility, Diversity, and Inclusion team met regularly with the education and programming team at the Center to review research findings for workshop segments, ideate and provide feedback on activities, and strategize to ensure a psychologically safe virtual environment for learners. Zoom registration was used for workshop registration. An evaluation survey, created by the LGBT Community Center of Greater Cleveland (Center), was deployed by the CTSC to learners after the workshop. Respondents reported that the LGBTQ+ terminology focus was most valuable. RESULTS/ANTICIPATED RESULTS: To maximize investment in and scale theLGBTQ+ Inclusivity For Researchers workshop, the LGBT Community Center of Greater Cleveland offered a shortened version to their Youth Participatory Action Research group and will continue to offer the workshop in their suite of program/educational offerings. The CTSC plans to offer opportunities to co-host the workshop at its hospital system partner institutions, with room to tailor content based on internal LGBT resources (e.g., gender care offered at the institution). We hope to see a remarkable increase in LGBTQ+ identifying researchers, LGBTQ+ participation in research studies and clinical trials, and LGBTQ+ research topics/ideas/questions in response to CTSC pilots, local, national, and global funding opportunities. DISCUSSION/SIGNIFICANCE: LGBTQ+ people are less likely to have a regular health care provider—impeding screening, diagnosis, and treatment. This is reflected in health research where clinical research participation may follow a diagnosis. By providing tools for LGBTQ+ research inclusion, we will catalyze more research with LGBTQ+ people—as researchers and participants.
5
Chawla, Ashok K., S. Randolph Hayas e Donald E. Zabriskie. "Group purchasing: Case reports: Center for Health Affairs, Greater Cleveland Hospital Association". American Journal of Health-System Pharmacy 44, n. 11 (1 novembre 1987): 2498–500. http://dx.doi.org/10.1093/ajhp/44.11.2498.
Testo completo
6
Fontenot, Kathryn, Edward Bush e Rebecca Gravois. "Lettuce Grow: Universities Collaborating with Nonprofits to Provide Child Care Development Educators with Garden Knowledge and Experience". HortTechnology 27, n. 5 (ottobre 2017): 700–703. http://dx.doi.org/10.21273/horttech03778-17.
Testo completoAbstract (sommario):
University-based horticulture departments and extension agents have explored the relationship between gardening programs and consumer knowledge and preferences. Studies have established positive correlations between garden participation and increased science scores and heightened environmental stewardship. The objective of this research was to determine if participation in “Lettuce Grow” garden workshops cohosted by the Louisiana State University Agriculture Center (LSU AgCenter) and Volunteers of America Greater Baton Rouge (VOA-GBR) had positive effects on child care providers’ garden knowledge and willingness to implement garden programming with children aged 5 years and younger. Participation led to a 67% increase (P ≤ 0.05) in horticulture knowledge for participants and resulted in 76.2% of the child care providers actively engaged in growing a garden with youth aged 5 years and under. Based on this experience, we highly recommend universities partner with local nonprofits to engage in deeper meaning, science-based garden extension projects.
7
Anderson, Neil O., Esther Gesick, Peter D. Ascher, Steven Poppe, Shengrui Yao, David Wildung, Patricia Johnson et al. "Mammoth™ ‘Twilight Pink Daisy’ Garden Chrysanthemum". HortScience 47, n. 8 (agosto 2012): 1182–86. http://dx.doi.org/10.21273/hortsci.47.8.1182.
Testo completoAbstract (sommario):
Mammoth™ ‘Twilight Pink Daisy’ (U.S. Plant Patent 14,455; Canadian Plant Breeders’ Rights Certificate No. 4192) is an interspecific garden chrysanthemum cultivar, Chrysanthemum ×hybridum Anderson (= Dendranthema ×hybrida Anderson) with common names of hardy mum, chrysanthemum, and garden mum. It is a new and distinct form of shrub-type garden mums in the Mammoth™ series with rosy-pink ray florets, a dark “eye” color in the center of the disc florets, frost-tolerant flower petals, and self-pinching growth. This cultivar is a butterfly attractant in the garden. Mammoth™ ‘Twilight Pink Daisy’ is a winter-hardy herbaceous perennial in USDA Z3b–Z9 (Southeast)/Zone 10 (West) with its cushion growth form displaying extreme hybrid vigor, increasing in plant height from 0.46 m in its first year to a shrub of 0.76 to 1.22 m in the second year and thereafter with greater than 3000 leaves/plant. Flowering is prolific, covering the entire plant at full flowering with as many as greater than 3500 flowers in the second year. Chemical abbreviations: ethanol (EtOH), indole-3-butyric acid (IBA).
8
Satterthwaite, Loretta N., John J. Haydu e Alan W. Hodges. "Consumer Purchasing Habits of Environmental Horticulture Products in Florida". Journal of Environmental Horticulture 24, n. 2 (1 giugno 2006): 68–73. http://dx.doi.org/10.24266/0738-2898-24.2.68.
Testo completoAbstract (sommario):
Abstract A garden center exit survey examining consumer purchasing habits of environmental horticulture products was conducted in Florida in 2002. A total of 910 surveys were completed with information on why a particular store was chosen for shopping, the items planned for purchase and whether or not the final purchase matched the intentions of the buyer. Convenience/location was the most important reason for shopping at a particular store, followed by price, quality, service, information and miscellaneous other reasons. Most respondents were shopping for non-plant (hardgood) items, but when shopping for plants, flowering plants for the outdoors were the most sought after. Seasonal shopping habits were identified with nearly every respondent shopping at least once during the spring and fewer respondents shopping at least once during each of the other seasons. Information was also collected on gender, age, education level, and annual income of respondents, as well as location and type of store (chain or independent). Respondents who reported having college level education, an annual income greater than $50,000 or were shopping at an independent garden center, also indicated convenience/location as their primary reason for selecting a particular garden center; however, unlike other respondents, price was not their second reason for shopping at a particular store.
9
Barton, S. S., J. R. Brooker, C. R. Hall e S. C. Turner. "Review of Customer Preference Research in the Nursery and Landscape Industry". Journal of Environmental Horticulture 16, n. 2 (1 giugno 1998): 118–24. http://dx.doi.org/10.24266/0738-2898-16.2.118.
Testo completoAbstract (sommario):
Abstract This paper outlines current, descriptive information about the retail plant customer's profile and identifies information needed to complete the profile as well as areas for continued research. Demographic studies that characterize the retail customer base vary with regional market and product lines included in the study. Mass merchandisers attract lower income customers; large, multiple outlet garden centers attract unmarried customers with higher incomes and greater value homes; and independent garden centers attract married, white females. Multiple studies support the conclusion that customers select outlets based primarily on plant quality and selection. Product quality is also the most important characteristic used by retailers when selecting a supplier. Location, price and professional staff also affect outlet selection. Mass merchandisers are selected for familiar, low-risk purchases, while independent garden centers are used for major purchases, when information is desired. The availability of trained, professional sales help is the service most desired by customers. Customers prefer to receive information in the garden center from professional staff and from nursery care tags. Customers prefer to purchase shrubs in containers. In one study, customers preferred to purchase balled and burlapped trees, while in another study trees were preferred in containers. Landscape architects prefer to purchase balled and burlapped plants.
10
Ni Nyoman Lidyantari, I Wayan Arta Artana e IGAB Widiantara. "PENGARUH KOMPENSASI DAN DISIPLIN KERJA TERHADAP KINERJA KARYAWAN DI BALAI KONSERVASI TUMBUHAN KEBUN RAYA EKA KARYA BALI". Journal of Tourism and Interdiciplinary Studies 1, n. 2 (10 gennaio 2023): 121–26. http://dx.doi.org/10.51713/jotis.v1i2.83.
Testo completoAbstract (sommario):
An organization manage HR with disciplined attitudes and behavior. Employee discipline can have a strong impact on an organization to achieve success. This study aims to determine the effect of compensation and work discipline partially on employee performance at the "Eka Karya" Botanical Garden Plant Conservation Center in Bali, which in one year in 2018 showed that there were employee delays above 47.10%. Therefore, the authors conducted a study by testing the hypothesis about how much influence compensation and work discipline had on employee performance at the Bali Botanic Garden. The approach of this research is quantitative research. So, to answer this hypothesis, it is done by taking a sample of 99 respondents. Data were tested using validity, reliability and classical assumptions and analyzed by multiple linear regression, T test, and F test. Based on the results of the analysis, a conclusion can be drawn as follows: Compensation (X1) has a positive and significant effect on performance (Y) at the Botanical Gardens Conservation Center "Eka Karya" Bali. The amount of regression coefficient b1X1 which is positive is 0.356. This test is supported by a statistical test t (t - test) which states that t count is greater than t table, which means H1 is accepted. Work discipline (X2) has a positive and significant effect on performance (Y) in the Botanical Gardens Conservation Center "Eka Karya" Bali. This can be seen from the regression coefficient b2X2 which is positive at 0.218. This test is supported by a statistical test t (t-test) which states that t count is greater than t table, which means H2 is accepted. Simultaneously compensation (X1) and work discipline (X2) have a positive and significant effect on performance (Y) in the Botanical Gardens Conservation Center "Eka Karya" Bali. This is evidenced through multiple regression analysis Y = 20,556 + 0,356X1 + 0,218X2. In addition, it is confirmed by the F (F-test) test where F count is greater than F table, which means Ho is rejected and H3 is accepted. Compensation is the dominant variable that influences performance in the Botanical Gardens Conservation Center "Eka Karya" Bali with a standarized beta coefficient of 0.553.
11
Duncan, Andra E., Daniel I. Sessler, Hiroaki Sato, Tamaki Sato, Keisuke Nakazawa, George Carvalho, Roupen Hatzakorzian et al. "Hyperinsulinemic Normoglycemia during Cardiac Surgery Reduces a Composite of 30-day Mortality and Serious In-hospital Complications". Anesthesiology 128, n. 6 (1 giugno 2018): 1125–39. http://dx.doi.org/10.1097/aln.0000000000002156.
Testo completoAbstract (sommario):
Abstract Background Hyperinsulinemic normoglycemia augments myocardial glucose uptake and utilization. We tested the hypothesis that hyperinsulinemic normoglycemia reduces 30-day mortality and morbidity after cardiac surgery. Methods This dual-center, parallel-group, superiority trial randomized cardiac surgical patients between August 2007 and March 2015 at the Cleveland Clinic, Cleveland, Ohio, and Royal Victoria Hospital, Montreal, Canada, to intraoperative glycemic management with (1) hyperinsulinemic normoglycemia, a fixed high-dose insulin and concomitant variable glucose infusion titrated to glucose concentrations of 80 to 110 mg · dl–1; or (2) standard glycemic management, low-dose insulin infusion targeting glucose greater than 150 mg · dl–1. The primary outcome was a composite of 30-day mortality, mechanical circulatory support, infection, renal or neurologic morbidity. Interim analyses were planned at each 12.5% enrollment of a maximum 2,790 patients. Results At the third interim analysis (n = 1,439; hyperinsulinemic normoglycemia, 709, standard glycemic management, 730; 52% of planned maximum), the efficacy boundary was crossed and study stopped per protocol. Time-weighted average glucose concentration (means ± SDs) with hyperinsulinemic normoglycemia was 108 ± 20 versus 150 ± 33 mg · dl–1 with standard glycemic management, P < 0.001. At least one component of the composite outcome occurred in 49 (6.9%) patients receiving hyperinsulinemic normoglycemia versus 82 (11.2%) receiving standard glucose management (P < efficacy boundary 0.0085); estimated relative risk (95% interim-adjusted CI) 0.62 (0.39 to 0.97), P = 0.0043. There was a treatment-by-site interaction (P = 0.063); relative risk for the composite outcome was 0.49 (0.26 to 0.91, P = 0.0007, n = 921) at Royal Victoria Hospital, but 0.96 (0.41 to 2.24, P = 0.89, n = 518) at the Cleveland Clinic. Severe hypoglycemia (less than 40 mg · dl–1) occurred in 6 (0.9%) patients. Conclusions Intraoperative hyperinsulinemic normoglycemia reduced mortality and morbidity after cardiac surgery. Providing exogenous glucose while targeting normoglycemia may be preferable to simply normalizing glucose concentrations.
12
Lineberger, Sarah, e J. M. Zajicek. "498 School Gardens: Do They Affect Children's Food Preferences and Eating Behaviors?" HortScience 34, n. 3 (giugno 1999): 531B—531. http://dx.doi.org/10.21273/hortsci.34.3.531b.
Testo completoAbstract (sommario):
Nutrition plays an important role in the life of a child because of the impact it has on growth, development, and the ability to learn. One part of proper nutrition is consumption of five fruits and vegetables a day. Currently, children eat an average of 2.5 fruits and vegetables a day, which is only half of the recommended servings. Education is needed to help increase consumption. School gardens are one education tool that can provide active hands-on activities in supportive environments. Through gardening, children learn not only what they should eat but also obtain a greater appreciation for how their food is grown. The main goals of this study were to provide teachers with a guide book for teaching nutrition through horticulture activities and school gardens and to test the effect of gardening on food preferences and eating behaviors of children. A curriculum guide, “Nutrition in the Garden”, was developed for teachers to use with their garden containing background information in horticulture and nutrition. Each lesson includes three to four related activities that can be completed with a garden or in the classroom. A pretest/posttest instrument developed by Tom Baranowski, Professor of Behavioral Science, Univ. of Texas MD Anderson Cancer Center, was used to determine students' attitudes toward fruits and vegetables. A 24-hour recall food journal was used to determine eating behaviors. Results examine the effects of school gardens on nutritional attitudes and behaviors.
13
Saager, Leif, Alparslan Turan, Cameron Egan, Edward J. Mascha, Andrea Kurz, Maria Bauer, Hervé Besson, Daniel I. Sessler e Brian D. Hesler. "Incidence of Intraoperative Hypersensitivity Reactions: A Registry Analysis". Anesthesiology 122, n. 3 (1 marzo 2015): 551–59. http://dx.doi.org/10.1097/aln.0000000000000529.
Testo completoAbstract (sommario):
Abstract Background: Previously reported incidences for intraoperative hypersensitivity reactions vary more than 15-fold. The goal was to determine the incidence of intraoperative hypersensitivity events at a U.S. surgical center. Methods: With institutional review board (Cleveland, Ohio) approval and waiver of written/informed consent, the anesthesia records of adult patients undergoing noncardiac surgery from 2005 to 2011 at the Cleveland Clinic were queried using a novel electronic search protocol developed to identify potential hypersensitivity reactions: cardiovascular collapse defined as systolic arterial blood pressure less than 50 mmHg; administration of epinephrine; administration of diphenhydramine; physician comments in the anesthesia record suggestive of hypersensitivity reactions; laboratory tests for histamine, tryptase, or immunoglobulin-E within 24 h of surgery; and International Classification of Diseases, Ninth Revision, codes suggestive of hypersensitivity reactions. Each electronically identified candidate chart was evaluated by an adjudication committee. Hypersensitivity reactions were graded on a 5-point severity scale. From these data, the authors determined the proportion of operations having adjudicated hypersensitivity reactions, and calculated the 95% exact binomial CI. Results: Among 178,746 records, 4,008 charts were identified by the search strategies. After adjudication, 264 hypersensitivity cases were identified. The overall incidence of hypersensitivity reactions was 1:677 surgeries, corresponding to 15 (95% CI, 13 to 17) cases per 10,000 operations. The incidence of severe hypersensitivity reactions (grades 3 to 5) was 1:4,583, corresponding to 2 (95% CI, 2 to 3) cases per 10,000 operations. Conclusions: The incidence of severe hypersensitivity reactions was similar to previous reports. However, the overall incidence of hypersensitivity reactions was much greater than reported elsewhere, possibly because of a comprehensive search strategy.
14
Behe, Bridget K., Melinda J. Knuth, Patricia T. Huddleston e Charles R. Hall. "Seeing Red? The Role of Font Color, Size, and Sale Sign Location in Retail Garden Center Displays1". Journal of Environmental Horticulture 38, n. 4 (1 dicembre 2020): 120–27. http://dx.doi.org/10.24266/0738-2898-38.4.120.
Testo completoAbstract (sommario):
Abstract The goal of this study was to better understand consumers' likelihood to buy a plant when the word “sale” was presented in red font on a white sign, with a range of font sizes, showing an equivalent discounted price in three ways (dollar amount, 25% percent off, and buy-3-get-1-free), with the sale sign location either on the left or right side of the display. Researchers constructed a partial factorial design with three plant types producing 16 images for the study. They recruited 154 subjects from two states. Results of the rating-based conjoint study revealed that plant type comprised 45% of the purchase decision, which was consistent with prior research. Price (23.8%) was the next most important factor in likely to buy followed by sale font size. Sale sign location and sale font color were similar and third and fourth, respectively, in relative importance. The synergistic effect of sale font size and color indicate that when red fonts were used for the word “sale” they should be larger than other font sizes and placed to the right in the display. Consumer gaze appeared to move from left to right as though study participants “read” the display. Results showed the red font had greater attention-grabbing power on the right side of the display and when it appeared in a larger or smaller font size. Index words: consumer, eye-tracking, price, survey, signage. Species used in this study: Pepper [Capsicum annuum L. (C. frutescens)], parsley Petroselinum crispum J. Hill, petunia (Petunia x hybrida Juss.), rosemary Rosmarinus officinalis L., sage (Salvia officinalis L.), tomato (Solanum lycopersicum L.).
15
Owings, Allen D. "Louisiana Select—Plant Promotion, Marketing, and Recommendation Efforts for the Nursery and Landscape Industry". HortScience 35, n. 4 (luglio 2000): 566A—566. http://dx.doi.org/10.21273/hortsci.35.4.566a.
Testo completoAbstract (sommario):
The LSU Agricultural Center and Louisiana Nursery and Landscape Association initiated an ornamental plant promtion, marketing, and recommendation program in 1996. Called `Louisiana Select', this program is intended to actively promote outstanding ornamental plants to Louisiana's gardening consumers. In addition, it provides county agents and industry professionals information on plants that should be recommended. The selection committee consists of an extension horticulturist, two county agents, a landscape contractor, a wholesale greenhouse grower, a wholesale woody ornamental producer, and two representatives from retail garden centers. Plants are usually promoted in the spring and fall of each year. Plants previously named as Louisiana Select recipients include `New Orleans Red' (Red Ruffle) coleus, mayhaw, `Henry's Garnet' virginia sweetspire, `Homestead Purple' perennial verbena, `Telstar' dianthus, bald cypress, `New Gold' lantana, `Confetti' lantana, `Trailing Purple' lantana, `Dallas Red' lantana, `Silver Mound' lantana, `Lady in Red' salvia, `New Wonder' scaevola, `Goldsturm' rudbeckia, and `Foxy' fox-glove. A theme (“Fall is for Planting Native Trees”) has also been promoted. Point of purchase signs promoting the Louisiana Select program and individual plants are made available to garden centers. Significant sales increases ranging from 300% to 2500% have been reported for seelcted plants with annual bedding plants and perennial flowers enjoying the greater sales volume increases.
16
Salas-Vega, Sebastian, Vikram B. Chakravarthy, Robert D. Winkelman, Matthew M. Grabowski, Ghaith Habboub, Jason W. Savage, Michael P. Steinmetz e Thomas E. Mroz. "Late-week surgery and discharge to specialty care associated with higher costs and longer lengths of stay after elective lumbar laminectomy". Journal of Neurosurgery: Spine 34, n. 6 (giugno 2021): 864–70. http://dx.doi.org/10.3171/2020.11.spine201403.
Testo completoAbstract (sommario):
OBJECTIVE In a healthcare landscape in which costs increasingly matter, the authors sought to distinguish among the clinical and nonclinical drivers of patient length of stay (LOS) in the hospital following elective lumbar laminectomy—a common spinal surgery that may be reimbursed using bundled payments—and to understand their relationships with patient outcomes and costs. METHODS Patients ≥ 18 years of age undergoing laminectomy surgery for degenerative lumbar spinal stenosis within the Cleveland Clinic health system between March 1, 2016, and February 1, 2019, were included in this analysis. Generalized linear modeling was used to assess the relationships between the day of surgery, patient discharge disposition, and hospital LOS, while adjusting for underlying patient health risks and other nonclinical factors, including the hospital surgery site and health insurance. RESULTS A total of 1359 eligible patients were included in the authors’ analysis. The mean LOS ranged between 2.01 and 2.47 days for Monday and Friday cases, respectively. The LOS was also notably longer for patients who were ultimately discharged to a skilled nursing facility (SNF) or rehabilitation center. A prolonged LOS occurring later in the week was not associated with greater underlying health risks, yet it nevertheless resulted in greater costs of care: the average total surgical costs for lumbar laminectomy were 20% greater for Friday cases than for Monday cases, and 24% greater for late-week cases than for early-week cases ultimately transferred to SNFs or rehabilitation centers. A Poisson generalized linear model fit the data best and showed that the comorbidity burden, surgery at a tertiary care center versus a community hospital, and the incidence of any postoperative complication were associated with significantly longer hospital stays. Discharge to home healthcare, SNFs, or rehabilitation centers, and late-week surgery were significant nonclinical predictors of LOS prolongation, even after adjusting for underlying patient health risks and insurance, with LOSs that were, for instance, 1.55 and 1.61 times longer for patients undergoing their procedure on Thursday and Friday compared to Monday, respectively. CONCLUSIONS Late-week surgeries are associated with a prolonged LOS, particularly when discharge is to an SNF or rehabilitation center. These findings point to opportunities to lower costs and improve outcomes associated with elective surgical care. Interventions to optimize surgical scheduling and perioperative care coordination could help reduce prolonged LOSs, lower costs, and, ultimately, give service line management personnel greater flexibility over how to use existing resources as they remain ahead of healthcare reforms.
17
Baumhardt, R. Louis, Lucas A. Haag, Prasanna H. Gowda, Robert C. Schwartz, Gary W. Marek e Freddie R. Lamm. "Modeling Cotton Growth and Yield Response to Irrigation Practices for Thermally Limited Growing Seasons in Kansas". Transactions of the ASABE 64, n. 1 (2021): 1–12. http://dx.doi.org/10.13031/trans.13877.
Testo completoAbstract (sommario):
HighlightsLater planting and greater site elevation or latitude decreased seasonal growing degree days and cotton yield in Kansas.Higher irrigation capacity (rate) usually increased lint yield, which was probably due to increased early boll load.Strategies for splitting land allocations between high irrigation rates and dryland did not increase production.Cotton may reduce irrigation withdrawals from the Ogallala aquifer, but the Kansas growing season limits production.Abstract. Precipitation in the western Great Plains averages about 450 mm, varying little with latitude and providing 40% to 80% of potential crop evapotranspiration (ETc). Supplemental irrigation is required to fully meet crop water demand, but the Ogallala or High Plains aquifer is essentially non-recharging south of Nebraska. Pumping water from this aquifer draws down water tables, leading to reduced water availability and deficit irrigation to produce an alternate crop such as cotton (Gossypium hirsutum L.) with a lower peak water demand than corn (Zea mays L.). Our objective was to compare simulated cotton yield response to emergence date, irrigation capacity, and application period at three western Kansas locations (Colby, Tribune, and Garden City) with varying seasonal energy or cumulative growing degree days (CGDD) and compare split center pivot deficit irrigation strategies with a fixed water supply (i.e., where portions of the center pivot land area are managed with different irrigation strategies). We used actual 1961-2000 location weather records with the GOSSYM simulation model to estimate yields of cotton planted into soil at 50% plant-available water for three emergence dates (DOY 145, 152, and 159) and all combinations of irrigation period (0, 4, 6, 8, and 10 weeks beginning at first square) and capacity (2.5, 3.75, and 5.0 mm d-1). Simulated lint yield and its ratio to ETc, or water use efficiency (WUE), consistently decreased with delayed planting (emergence) as location elevation or latitude increased due to effects on growing season CGDD. Depending on location, simulated cotton lint consistently increased (p = 0.05) for scenarios with increasing irrigation capacity, which promoted greater early season boll load, but not for durations exceeding 4 to 6 weeks, probably because later irrigation and fruiting did not complete maturation during the short growing season. Cotton WUE generally increased, with greater yields resulting from earlier emergence and early high-capacity irrigation. We calculated lower WUE where irrigation promoted vigorous growth with added fruiting forms that delayed maturation and reduced the fraction of open bolls. The irrigation strategy of focusing water at higher capacities on a portion of the center pivot in combination with the dryland balance did not increase net yields significantly at any location because the available seasonal energy limited potential crop growth and yield response to irrigation. However, the overall net lint yield was numerically larger for focused irrigation strategies at the southwest Kansas location (Garden City). Based on lint yields simulated under uniform or split center pivot deficit irrigation, we conclude that cotton is poorly suited as an alternative crop for central western and northwestern Kansas because of limited growing season CGDD. Keywords: Cotton, Crop simulation, Deficit irrigation, Evapotranspiration, Irrigation capacity, Split center pivot irrigation, Water use efficiency, Yield limiting factors.
18
Ferraz, Claudia, Samira Maria Achkar e Ivanete Kotait. "First report of rabies in vampire bats (Desmodus rotundus) in an urban area, Ubatuba, São Paulo state, Brazil". Revista do Instituto de Medicina Tropical de São Paulo 49, n. 6 (dicembre 2007): 389–90. http://dx.doi.org/10.1590/s0036-46652007000600010.
Testo completoAbstract (sommario):
The purpose of this report is to record the first case of a hematophagous bat (Desmodus rotundus) infected with rabies virus in an urban area in Brazil. To the authors' knowledge, this is the first such case in Latin America. After discovering a bat in his garden at 10 o'clock in the morning, a resident of Ubatuba municipality asked the Zoonosis Control Center team to visit his home. The animal was caught alive on the same day and sent to the Pasteur Institute laboratory, where it was identified as a Desmodus rotundus specimen. Standard tests for rabies diagnosis were carried out (direct immunofluorescence and viral isolation), and the results were positive. The presence of different species of (primarily insectivorous) bats in urban areas represents a serious public health problem. This case, however, is indicative of a much greater risk because the species in question has hematophagous habits, what means this animals has a low energy reserves and, therefore, its need to feed daily.
19
Owings, Allen D. "Louisiana Select: Taking the Plants to the People". HortScience 33, n. 4 (luglio 1998): 603f—604. http://dx.doi.org/10.21273/hortsci.33.4.603f.
Testo completoAbstract (sommario):
The LSU Agricultural Center and Louisiana Association of Nurserymen initiated an ornamental plant promotion and recommendation program in 1996. Called `Louisiana Select', this program is intended to actively promote outstanding ornamental plants to Louisiana's gardening consumers. Plants are promoted in the spring and fall of each year and have included `New Orleans Red' coleus, mayhaw, `Henry's Garnet' Virginia willow, `Homestead Purple' verbena, `Watchet' azalea, `Telstar' dianthus, bald cypress, `New Wonder' scaevola, “Fall is for Planting Native Trees”, and lantana (`New Gold', `Dallas Red', `Confetti', `Trailing Purple', and `Silver Mound'). Point of purchase signs and banners promoting the `Louisiana Select' program and individual plants are provided to retail garden centers. Significant sales increases ranging from 300% to 2500% have been reported for the selected plants, with annual bedding plants and perennial flowers enjoying the greater sales increases. Plants for promotion are selected by a committee of wholesale greenhouse producers, retailers, landscape contractors, and cooperative extension service personnel.
20
Sajatovic, Martha, Lynn Herrmann, Clare Knebusch, Kaylee Sarna, Alan Lerner, Edna Fuentes-Casiano e Christopher Burant. "TARGETING KNOWLEDGE, BARRIERS, AND FACILITATORS TO PARTICIPATION IN DEMENTIA RESEARCH (THE POWER PROJECT)". Innovation in Aging 6, Supplement_1 (1 novembre 2022): 487–88. http://dx.doi.org/10.1093/geroni/igac059.1878.
Testo completoAbstract (sommario):
Abstract Racial and ethnic minorities are under-represented in dementia research. We tested a conceptually-driven health communication approach targeting evidence-based barriers and facilitators to research participation vs. dementia awareness training. Input from the minority advisory board (MAB) of the Cleveland Alzheimer’s Disease Research Center (CADRC) informed development of 2 brief health communication videos which differentially focused on research barriers and facilitators (POWER) versus an education control (EDU). A randomized controlled on-line survey compared POWER vs. EDU among 200 individuals ≥ 50 years. We examined pre/post video change in research motivation measured by the transtheoretical model, dementia knowledge and cumulative barriers and facilitators. Interim analysis included 129 individuals who completed the pre-video survey, mean age 58.8 (SD 14.9), 101 (78.3 %) women, 54 (41.9 %) non-white. 100 (77.5 %) completed the post-video survey. Whole sample dementia knowledge improved from pre (mean 4.6, SD 1.3) vs. post (5.8, SD 0.7) video (p <.01), as did facilitators to research from pre (22.4, SD 2.7) vs. post (22.8, SD 3.0) video (p=.02), while there was no significant change in barriers. Research motivation was increased pre (10.8, SD 2.0) vs. post (22.8, SD 3.0) video (p=.02). Overall, dementia knowledge improved more with EDU vs. POWER (p=.04). African-American participants trended towards greater improvement in dementia knowledge with EDU vs. POWER (p=.07), while non-African-Americans had greater facilitator improvement with POWER vs. EDU (p=.03). Targeted communication approaches that address knowledge gaps and both barriers and facilitators to participation may improve engagement of diverse groups in dementia research.
21
Knuth, Melinda, Bridget K. Behe e Patricia T. Huddleston. "Simple or complex? Consumer response to display signs". Interdisciplinary Journal of Signage and Wayfinding 4, n. 2 (21 agosto 2020): 7–22. http://dx.doi.org/10.15763/issn.2470-9670.2020.v4.i2.a67.
Testo completoAbstract (sommario):
Retail signage provides information from the marketer to facilitate product purchase. An increase in sign information creates greater sign complexity, which raises the question: for consumer product choices, what quantity of information is helpful versus overwhelming? We hypothesize that consumers would allocate more visual attention to complex signs and that sign complexity would be a predictor of likeliness to buy (LTB). Five experts rated 105 real garden center signs for complexity and five low, moderate, and highcomplexity signs were selected for the study. Signs were incorporated into Tobii X1 Light Eye Tracker software, where 85 non-student subjects rated sign attractiveness and LTB from a display containing that sign. Subjects allocated greater visual attention (higher fixation count and longer total fixation duration) to more complex signs, which were also rated as most attractive. Initial regression results showed sign attractiveness and fixation count were positive predictors of LTB, while complexity and total fixation duration were inversely related to LTB. Mediation analysis showed that fixation duration fully mediates fixation count impact on purchase intention. Results suggest that informationrich messaging in high complexity signs, while seen as attractive, may give consumers too much information and higher cognitive load, which makes decision-making more difficult.
22
Heald, Brandie, Thomas Plesec, Xiuli Liu, Rish Pai, Deepa Patil, Jessica Moline, Richard R. Sharp et al. "Implementation of Universal Microsatellite Instability and Immunohistochemistry Screening for Diagnosing Lynch Syndrome in a Large Academic Medical Center". Journal of Clinical Oncology 31, n. 10 (1 aprile 2013): 1336–40. http://dx.doi.org/10.1200/jco.2012.45.1674.
Testo completoAbstract (sommario):
Purpose In 2009, the Evaluation of Genomic Applications in Practice and Prevention recommended that all colorectal cancers (CRCs) be screened for Lynch syndrome (LS) through microsatellite instability (MSI) or immunohistochemistry (IHC). No studies report how this process is implemented on a health system–wide basis. Methods Since 2004, Cleveland Clinic has screened CRC specimens with MSI/IHC. Between January 2004 and July 2007, MSI/IHC results went only to the colorectal surgeon (approach 1). Between August 2007 and June 2008, colorectal surgeons and a genetic counselor received the MSI/IHC results, and the counselor e-mailed the colorectal surgeon regarding appropriate patients for genetic counseling (GC) referral (approach 2). After July 2008, the colorectal surgeon and counselor received MSI/IHC results, but the counselor contacted the patient to facilitate referral (approach 3). In approaches 2 and 3, patients were presumed to have sporadic CRC if the tumor lacked MLH1 expression and was also BRAF mutated or if the patient was diagnosed at age greater than 72 years and had no cancer family history. Results Abnormal MSI/IHC results occurred in 178 (16%) of 1,108 patients. In approach 1, 21 (55%) of 38 patients with abnormal MSI/IHC were referred for GC, 12 (32%) of 38 underwent GC, and 10 (26%) of 38 underwent genetic testing (GT). In approach 2, nine (82%) of 11 patients were referred for GC, seven (64%) of 11 underwent GC, and five (45%) of 11 underwent GT. In approach 3, 56 (100%) of 56 patients were referred for GC, 40 (71%) of 56 underwent GC, and 37 (66%) of 56 underwent GT. Time from referral to GC was 10-fold quicker in approach 3 than approach 1. Conclusion Implementation of universal MSI/IHC with GC/GT, along with effective multidisciplinary communication and plans of responsibility for patient contact, resulted in increased identification of patients with LS.
23
Suchoń, Aneta. "Selected legal issues related to agricultural real estate during the COVID-19 pandemic". Nieruchomości@ Specjalne, n. V (15 dicembre 2021): 243–63. http://dx.doi.org/10.5604/01.3001.0015.5834.
Testo completoAbstract (sommario):
The aim of the article was to determine whether, during the COVID-19 pandemic, the provisions on agricultural real estate, including those contained in the Act of April 11, 2003 on shaping the agricultural system (hereinafter UKUR), matched the socio-economic needs. Secondly, whether and to what extent agricultural producers running agricultural activity on agricultural real estate obtained additional aid due to the epidemic. First, the considerations focus on the acquisition of agricultural real estate with an area of up to 1 ha and often used for the construction of a house with a home garden. Reference is also made to the statistical data on the exercise of the pre-emption right and the acquisition by the National Center for Agricultural Support. Subsequently, the issue of ensuring food and food security in times of the pandemic is indicated to be of greater importance in the context of the obligations of the owners of agricultural real estate, including running a farm for 5 to 15 years after its acquisition. Next, the considerations focus on state support for agricultural producers during the COVID-19 pandemic, referring to lease tenders conducted by the National Center for Agricultural Support, the rules for paying tax, EU aid and benefits granted to agricultural producers in relation to the COVID-19 pandemic. Finally, the problem of making investments in renewable energy on agricultural land and concluded lease agreements is discussed.
24
Beidelschies, Michelle, Marilyn Alejandro-Rodriguez, Ning Guo, Anna Postan, Tawny Jones, Elizabeth Bradley, Mark Hyman e Michael B. Rothberg. "Patient outcomes and costs associated with functional medicine-based care in a shared versus individual setting for patients with chronic conditions: a retrospective cohort study". BMJ Open 11, n. 4 (aprile 2021): e048294. http://dx.doi.org/10.1136/bmjopen-2020-048294.
Testo completoAbstract (sommario):
ObjectiveTo compare outcomes and costs associated with functional medicine-based care delivered in a shared medical appointment (SMA) to those delivered through individual appointments.DesignA retrospective cohort study was performed to assess outcomes and cost to deliver care to patients in SMAs and compared with Propensity Score (PS)-matched patients in individual appointments.SettingA single-centre study performed at Cleveland Clinic Center for Functional Medicine.ParticipantsA total of 9778 patients were assessed for eligibility and 7323 excluded. The sample included 2455 patients (226 SMAs and 2229 individual appointments) aged ≥18 years who participated in in-person SMAs or individual appointments between 1 March 2017 and 31 December 2019. Patients had a baseline Patient-Reported Outcome Measurement Information System (PROMIS) Global Physical Health (GPH) score and follow-up score at 3 months. Patients were PS-matched 1:1 with 213 per group based on age, sex, race, marital status, income, weight, body mass index, blood pressure (BP), PROMIS score and functional medicine diagnostic category.Primary and secondary outcome measuresThe primary outcome was change in PROMIS GPH at 3 months. Secondary outcomes included change in PROMIS Global Mental Health (GMH), biometrics, and cost.ResultsAmong 213 PS-matched pairs, patients in SMAs exhibited greater improvements at 3 months in PROMIS GPH T-scores (mean difference 1.18 (95% CI 0.14 to 2.22), p=0.03) and PROMIS GMH T-scores (mean difference 1.78 (95% CI 0.66 to 2.89), p=0.002) than patients in individual appointments. SMA patients also experienced greater weight loss (kg) than patients in individual appointments (mean difference −1.4 (95% CI −2.15 to −0.64), p<0.001). Both groups experienced a 5.5 mm Hg improvement in systolic BP. SMAs were also less costly to deliver than individual appointments.ConclusionSMAs deliver functional medicine-based care that improves outcomes more than care delivered in individual appointments and is less costly to deliver.
25
Fallah, Aria, Shaun D. Rodgers, Alexander G. Weil, Sumeet Vadera, Alireza Mansouri, Mary B. Connolly, Philippe Major et al. "Resective Epilepsy Surgery for Tuberous Sclerosis in Children". Neurosurgery 77, n. 4 (26 giugno 2015): 517–24. http://dx.doi.org/10.1227/neu.0000000000000875.
Testo completoAbstract (sommario):
Abstract BACKGROUND: There are no established variables that predict the success of curative resective epilepsy surgery in children with tuberous sclerosis complex (TSC). OBJECTIVE: We performed a multicenter observational study to identify preoperative factors associated with seizure outcome in children with TSC undergoing resective epilepsy surgery. METHODS: A retrospective chart review was performed in eligible children at New York Medical Center, Miami Children's Hospital, Cleveland Clinic Foundation, BC Children's Hospital, Hospital for Sick Children, and Sainte-Justine Hospital between January 2005 and December 2013. A time-to-event analysis was performed. The “event” was defined as seizures after resective epilepsy surgery. RESULTS: Seventy-four patients (41 male) were included. The median age of the patients at the time of surgery was 120 months (range, 3-216 months). The median time to seizure recurrence was 24.0 ± 12.7 months. Engel Class I outcome was achieved in 48 (65%) and 37 (50%) patients at 1- and 2-year follow-up, respectively. On univariate analyses, younger age at seizure onset (hazard ratio [HR]: 2.03, 95% confidence interval [CI]: 1.03-4.00, P = .04), larger size of predominant tuber (HR: 1.03, 95% CI: 0.99-1.06, P = .12), and resection larger than a tuberectomy (HR: 1.86, 95% CI: 0.92-3.74, P = .084) were associated with a longer duration of seizure freedom. In multivariate analyses, resection larger than a tuberectomy (HR: 2.90, 95% CI: 1.17-7.18, P = .022) was independently associated with a longer duration of seizure freedom. CONCLUSION: In this large consecutive cohort of children with TSC and medically intractable epilepsy, a greater extent of resection (more than just the tuber) is associated with a greater probability of seizure freedom. This suggests that the epileptogenic zone may include the cortex surrounding the presumed offending tuber.
26
Dunn, Joe P. "The National Model League of Arab States". Political Science Teacher 3, n. 1 (1990): 19–20. http://dx.doi.org/10.1017/s0896082800000945.
Testo completoAbstract (sommario):
Among the excellent national simulations available—the Harvard Model UN, Cleveland Model UN, Howard University Model Organization of African States, etc., and several regional models—the best may be the National Model League of Arab States, held annually in March at American University in Washington, DC. Sponsored by the Arab League Information Center and the National Council on U.S.-Arab Relations, the Model (in its seventh year in 1989) imitates the League of Arab States, an organization founded in 1945 for the purpose of coordinating issues related to Arab development and cooperation.College and university student delegations represent the 22 member states of the Arab nation. As they debate, lobby, and caucus, students learn about the interplay of the state system, international and regional organization, intra-Arab cooperation and conflict, issues of the region, and superpower impact upon the area. As participants gain greater understanding of the culture, concerns, achievements, and problems of the Arab world, they shed stereotypes, question prejudices, and begin to appreciate another perspective on regional issues.The Model League consists of plenary sessions, five committees (political, economic, social and cultural, legal, and Palestinian affairs), and a summit conference of the League Council. The bulk of time is spent in the committee sessions, where students introduce, debate, and build coalitions in support of resolutions. In the process, they practice parliamentary procedure and sharpen forensic and bargaining skills. Faculty advisors evaluate the delegations and nominate individuals for awards.
27
Markman, Maurie, Alexander Kennedy, Kenneth Webster, Gertrude Peterson, Barbara Kulp e Jerome Belinson. "Combination Chemotherapy With Carboplatin and Docetaxel in the Treatment of Cancers of the Ovary and Fallopian Tube and Primary Carcinoma of the Peritoneum". Journal of Clinical Oncology 19, n. 7 (1 aprile 2001): 1901–5. http://dx.doi.org/10.1200/jco.2001.19.7.1901.
Testo completoAbstract (sommario):
PURPOSE: Standard chemotherapy for advanced ovarian cancer currently includes a platinum agent (usually carboplatin) and paclitaxel. Because docetaxel is an active agent in platinum-resistant ovarian cancer, it is relevant to evaluate both the toxicity and efficacy of the combination of carboplatin and docetaxel in this clinical setting. PATIENTS AND METHODS: The Gynecologic Oncology Program of the Cleveland Clinic Taussig Cancer Center conducted a phase II trial of carboplatin (area under the concentration-versus-time curve of 6) and docetaxel (60 mg/m2), delivered every 3 weeks for six courses, in patients with ovarian and fallopian tube cancers and primary carcinoma of the peritoneum who had either received no prior chemotherapy or had experienced a treatment-free interval of greater than 2 years before developing disease recurrence. RESULTS: Fifty patients (median age, 57 years; range, 44 to 81 years) entered the trial (47 had had no prior chemotherapy). Our toxicity findings included the following: grade 4 neutropenia (64% of patients); hypersensitivity reactions (34%, none requiring discontinuation of therapy); peripheral neuropathy (6%). We had objective responses for 32 of 42 (81%) assessable patients. CONCLUSION: The combination of carboplatin and docetaxel is highly active in ovarian cancer, with the major toxicity being bone marrow suppression. Hypersensitivity reactions are frequent but do not prevent continuation of treatment. With the dose and schedule employed in this trial, neurotoxicity is uncommon. Defining a role for this regimen in routine clinical practice will require the conduct of randomized controlled clinical trials.
28
Rotz, Seth, Mary Ann O'Riordan, Ceonne Kim, Marcos de Lima, Mark T. Gladwin e Jane A. Little. "Stop Light: Mortality Risk In Adult Sickle Cell Disease and Criteria For Hematopoietic Stem Cell Transplant". Blood 122, n. 21 (15 novembre 2013): 2227. http://dx.doi.org/10.1182/blood.v122.21.2227.2227.
Testo completoAbstract (sommario):
Abstract Introduction The integration of prognostic information into the clinical care of adults with sickle cell disease (SCD) assumes greater importance as more intensive therapeutic strategies are being developed, including hematopoietic stem cell transplantation (HSCT). In addition, more high-risk alternate donor options predominate in SCD, since allogeneic HSCT candidates seldom have matched sibling donors (MSD). We wanted to integrate individual clinical risk factors for death, such as white blood cell count (Platt, NEJM, 1994) or Tricuspid Regurgitant Jet Velocity (TRV), (Gladwin, NEJM, 2004) into eligibility criteria for HSCT. Methods Baseline demographics, laboratory values, high-risk TRV (greater than 3.0 m/s), and 2-year mortality data on adults with SCD, available from the multi-centered Walk-PHaSST study (n=468 HbSS, 19 deaths), were used to estimate one- and two-variable positive predictive values (PPVs) for short-term mortality (Figure 1A). Using these data, we suggest the basis for a graded (‘stop light') HSCT eligibility schema in which patients with morbid disease and <10% 2-year mortality (green light, ‘low risk' disease) could be considered for standard-risk HSCT (e.g. reduced-intensity MSD) (Figure 1B). 10-15% mortality (yellow light, ‘moderate risk') or highly morbid disease could be considered for alternate donor transplants in which there is published experience in adults (e.g. reduced intensity haploidentical, Bolanos-Meade, Blood 2012). >15% mortality (red light, ‘high risk' disease) could be considered for high-risk alternate donor transplants (without published experience in adults, e.g. cord blood). We then applied this method for estimating HSCT eligibility to HbSS adults followed at University Hospitals Case Medical Center in Cleveland, Ohio (n=122), and contrasted this with criteria based on published recommendations (Hseih, NEJM, 2009), (STRIDE trial: http://clinicaltrials.gov/show/NCT01565616). Results We developed a simple mortality-based prognostic scale with which to estimate SCD severity prior to referring for HSCT. In Walk-PHASST, multiple clinical variables contributed to high risk SCD (red boxes, Figure 1A). The Cleveland population is young (median age 28 years). Nonetheless, 23% (28 of 122) were high risk (red) patients, and 52% (64 of 122) were moderate risk (yellow) or had highly morbid disease. 12% (15 of 122) had low risk (green) SCD and morbid disease, based on our proposed ‘stop light' eligibility schema. Published eligibility criteria, which do not stratify based on SCD prognosis, identify 75-86% of adults in our center as having ≥1 indications for HSCT. Conclusions Although estimation of risk from transplant is evolving, we believe the proposed ‘stop light' graded eligibility may aid in the selection of appropriate patients and in risk-benefit counseling. We recognize the limitations of a scale based on a modest number of deaths. Nonetheless our simple mortality based prognostic scale is a tool with which to approach the integration of disease severity and HSCT risk in SCD. Yellow: Patients at moderate risk for 2-year (10-15%) mortality (yellow boxes, Figure 1A) or with highly morbid disease (>5 hospitalizations per year, h/o CVA, h/o silent infarct, estimated GFR <90 mL/min, macroalbuminuria, ≥2 ACS within 5 years, or sickle hepatopathy) are eligible for alternate donors with which there is published experience in adults (e.g. haploidentical as well as MSD). Green: Patients with 2-year mortality (<10%) but with morbid disease (>2 hospitalizations per year for two or more years, or acute chest within the past five years) are eligible for standard-risk HSCT (MSD only). Disclosures: No relevant conflicts of interest to declare.
29
Heinzinger, Catherine, Nicolas Thompson, Alex Milinovich, Nancy Foldvary-Schaefer, David Van Wagoner, Mina Chung e Reena Mehra. "0745 Sleep-Related Hypoxemia Association with Incident Atrial Fibrillation in a Clinic-Based Cohort". Sleep 45, Supplement_1 (25 maggio 2022): A325. http://dx.doi.org/10.1093/sleep/zsac079.741.
Testo completoAbstract (sommario):
Abstract Introduction Sleep disordered breathing (SDB) has been implicated in atrial fibrillation (AF) in population-based studies, however, its role remains unclear and inconsistent. We hypothesize greater risk of 5-year incident AF with SDB and sleep-related hypoxia in a clinic-based cohort. Methods Cleveland Clinic patients (age>18) who underwent polysomnogram (PSG) or split studies 11/27/2004-12/30/2015 with >3 hours diagnostic time were examined. Predictors include AHI, % sleep time oxygen saturation<90% (T90), and minimum and mean oxygen saturation(minSaO2 and meanSaO2, respectively). Cox proportional hazard models were fit with time from sleep study to AF diagnosis as the dependent variable. Covariates included age, sex, race, body mass index(BMI), cardiovascular risk factors (hypertension, diabetes mellitus, hyperlipidemia), heart failure, coronary artery disease, myocardial infarction, history of coronary artery bypass grafting, chronic obstructive pulmonary disease, tobacco use, and use of anti-arrhythmic drugs. Data were censored at date of last follow up or at 5-years. Results The sample was comprised of 43,634 patients: age 51.7±14.5, 51.9% male, 74.5% White, and 7.1%(n=3,090) with AF. Of those without AF, 1,176(2.9%) developed 5-year incident AF. For each 10% increase in T90, incident AF increased by 7% (HR=1.07, 95%CI=1.05-1.10). Compared to reference, patients with 25.01-50%, 50.01-75%, and 75.01-100% time T90 had 22% (HR=1.22, 95%CI=1.01-1.46), 49% (HR=1.49, 95%CI=1.20-1.85), and 65% (HR=1.65, 95%CI=1.26-2.15) higher incident AF, respectively. For every 10-unit increase in minSaO2 and meanSaO2, incident AF decreased by 11%(HR=0.89, 95%CI=0.83-0.95) and 23% (HR=0.77, 95%CI=0.68-0.86), respectively. AHI did not demonstrate a statistically significant relationship with incident AF at a significance level of 0.05. Conclusion Sleep-related hypoxemia, defined by cumulative burden below 90% SaO2, demonstrated an association with incident AF in this large clinic-based cohort, even considering confounding factors. On the other hand, SDB severity as defined by AHI did not demonstrate this relationship. These findings are consistent with experimental models that identify intermittent hypoxia and oxidative stress leading to alterations of the cardiac substrate, thus implicating sleep-related hypoxemic mechanisms as a salient driver in the evolution of atrial arrhythmogenesis. Support (If Any) Cleveland Clinic Neurological Institute Center for Outcomes Research & Education Pilot Grant, Neuroscience Transformative Research Resource Development Award
30
Vorster, Sarel J., e Gene H. Barnett. "A proposed preoperative grading scheme to assess risk for surgical resection of primary and secondary intraaxial supratentorial brain tumors". Neurosurgical Focus 4, n. 6 (giugno 1998): E4. http://dx.doi.org/10.3171/foc.1998.4.6.5.
Testo completoAbstract (sommario):
Although surgical resection of brain tumors has been performed for over a century, complications still occur with distressing frequency. The authors propose a simple preoperative grading scheme to assess surgical risk for resection of primary and secondary intraaxial supratentorial brain tumors. The authors retrospectively reviewed the clinical records, neuroimaging studies, and outcomes of 224 surgeries performed in 207 patients from January 1993 to December 1995 at the Cleveland Clinic Foundation Brain Tumor Center. Subsequently, they considered and statistically analyzed multiple variables related to the patients and their lesions. Surgical risk was defined as any complication occurring within 30 days postoperatively, and was divided into transient operative complications, transient medical complications, and new sustained neurological deficits. Length of stay was also recorded. The overall incidence of complications was 10.6% and the mortality rate was 2.7%, with a median hospital stay of 3 days. Patient age greater than 60 years (p < 0.001), preoperative Karnofsky Performance Scale scores of 50 or less (p < 0.03), previous irradiation (p < 0.001), tumor location in eloquent regions (p < 0.03), and depth of tumor invasion (p < 0.001) independently predicted complicated outcome or increased length of stay. Finally, the authors derived a simple five-tier grading scheme in which these patient risk factors are added together to obtain a grade of I to V that corresponds to outcome and length of hospital stay. This grading scheme may be used to identify patients at higher risk and facilitate comparison of results between institutions and individual surgeons.
31
Liu, James K. C., Hesham Soliman, Andre Machado, Milind Deogaonkar e Ali R. Rezai. "Intracranial hemorrhage after removal of deep brain stimulation electrodes". Journal of Neurosurgery 116, n. 3 (marzo 2012): 525–28. http://dx.doi.org/10.3171/2011.10.jns11465.
Testo completoAbstract (sommario):
Object Many previous studies have shown that placement of deep brain stimulation (DBS) electrodes carries a considerable risk of hemorrhage. To date, no studies have evaluated the incidence of intracranial hemorrhage after removal of DBS electrodes. The authors performed a retrospective chart review to identify the incidence and trends in hemorrhage after DBS electrode removal. Methods A retrospective chart review of all DBS electrodes removed at the Cleveland Clinic between October 2000 and May 2010 was performed. All patients underwent postoperative CT scanning. Each patient was evaluated for age, sex, side of placement, target, duration of lead placement, reason for removal, and medical comorbidities. Results A total of 78 lead removals were performed in the 10-year period (1300 leads were implanted during the same period). Of the 78 leads removed, 10 (12.8%) resulted in hemorrhages seen on postoperative CT scans. The hemorrhages were superficial cortical in 6 cases of lead removal (60%) and deep in 4 cases (40%). No statistically significant correlation to any of the factors evaluated was found. All hemorrhages were asymptomatic. The authors' retrospective study of 78 DBS lead removals revealed a high risk of intracranial hemorrhage (12.8% per lead). The risk of hemorrhage during removal is significantly greater than the risk of hemorrhage during implantation (2.0% per lead at the authors' center during the same period). There were more superficial hemorrhages, and all hemorrhages were asymptomatic. Conclusions Removal of DBS leads carries a significantly higher risk of postoperative hemorrhages that are seen on images but are not clinically symptomatic.
32
Akpoji, Ukwen, Brigid Wilson, Tayoot Chengsupanimit, Sunah Song, Taissa Bej, Robin Jump e Federico Perez. "In veteran outpatients, antibiotics remain significant risk factor for community-acquired Clostridiodes difficile infection". Antimicrobial Stewardship & Healthcare Epidemiology 2, S1 (16 maggio 2022): s26—s27. http://dx.doi.org/10.1017/ash.2022.104.
Testo completoAbstract (sommario):
Background: An estimated 30% of antibiotic prescriptions in outpatient settings may be inappropriate. Antibiotic exposure increases an individual’s risk of Clostridioides difficile infection (CDI). To assess the prevalence of community-acquired CDI (CA-CDI) among patients without recent hospitalization and to examine the influence of outpatient antibiotic exposure on the risk of acquiring CA-CDI in this population, we examined a 2-year cohort of patients seen in primary care clinics at VA community-based outpatient clinics (CBOCs) associated with a large VA medical center. Methods: All primary care visits and nonvisit antibiotic prescriptions were identified in calendar years 2018–2019 as encounters of interest. Encounters occurring Results: We identified 84,787 patients with visits meeting our criteria. In this cohort, 3,533 patients were prescribed antibiotics at their encounter of whom 5 (0.14%) developed CA-CDI. Among the 81,254 patients who were not prescribed antibiotics, 15 (0.02%) developed CA-CDI, yielding an unadjusted CA-CDI odds ratio of 7.68 (95% CI, 2.50–19.82). p Conclusions: Although CA-CDI episodes were infrequent among VA outpatients with a CBOC visit in 2018–2019, the odds of CA-CDI were 7-fold greater in outpatients with antibiotic exposure than outpatients without antibiotic exposure. Antibiotic stewardship interventions that emphasize adverse events as a result of care provided in the outpatient setting, rather than as events limited to acute-care settings, may mitigate CDI risk.Funding: This work was supported by the Merck Investigator Studies Program (MISP 59266 to F.P. and R.J.), and funds and facilities were provided by the Cleveland Geriatric Research Education and Clinical Center (GRECC) at the VA Northeast Ohio Healthcare System. The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.Disclosures:. All authors report no conflicts of interest relevant to this article. R.J. has received research funding from Pfizer; she has also participated in advisory boards for Pfizer and Merck.
33
Treiman, Thomas, e Justine Gartner. "What Do People Want From Their Community Forests? Results Of A Public Attitude Survey In Missouri, U.S." Arboriculture & Urban Forestry 31, n. 5 (1 settembre 2005): 243–50. http://dx.doi.org/10.48044/jauf.2005.031.
Testo completoAbstract (sommario):
A self-administered survey of randomly selected recipients in 44 Missouri, U.S., communities found that most Missourians were very concerned about the quality of natural resources and having trees on streets and in parks. Respondents felt that Missouri was not doing well at making sure fewer trees are lost during development and at managing stormwater runoff. Residents in communities with a population of 50,000 or more, in the St. Louis and Kansas City suburbs, and in the cities of St. Louis and Kansas City show strong support for a ballot issue establishing a tree fund supported by a tax of US$5 or less. Missourians in communities with a population greater than 5,000 showed support for protecting or replacing trees during development through passage of a tree preservation ordinance. They lack basic knowledge of their community's tree program and could not correctly say whether their community was certified by The National Arbor Day Foundation as a Tree City USA. They are most likely to seek information on trees from their local garden center. The results of the survey, together with recent surveys of community forestry officials and street tree inventories, are used to make recommendations to state agencies charged with managing community forests.
34
Bagdatlı, M. Cüneyt, e Esra Can. "SPATIAL EVALUATION OF LAND AND SOIL PROPERTIES IN THE EXAMPLE OF NEVŞEHİR PROVINCE, TURKEY". International Journal of Engineering Technologies and Management Research 8, n. 7 (2 agosto 2021): 90–102. http://dx.doi.org/10.29121/ijetmr.v8.i7.2021.1007.
Testo completoAbstract (sommario):
In this study, some land and soil properties were spatially evaluated with the help of 1/25.000 scaled digital soil maps belonging to Center of province in the Central Anatolia Region, Turkey. Land use capability, large soil groups, soil depths, erosion, slope and spatial distributions of current land uses were carried out in the research. Arc GIS 10.3.1 software, which is one of the Geographic Information Systems (GIS) software, was used for spatial analysis. With a maximum of 262518 in the study area, VI. class lands. Class I cover an area of 247 . In terms of large soil groups, and soils are dominant and the area covered by these soils is 450187 . The least area was found to be reddish brown soils with 124 . It has been determined that the least area in the depth classes is A class (greater than 150 cm) soils. In the study area, it is the soil with the maximum C class (50-90 cm) depth. When the land was examined in terms of slope, it was determined that the land with the highest 3rd degree slope (12-20%) was formed. The research area consists of soil structure that can be exposed to the 2nd degree erosion class at most. When the current land uses are examined, it is the garden area with the least usage area in the region and the area it covers is 3400 . It has been observed that the most dry farming areas are located in the study area. It is thought that the results obtained as a result of the study will be the basis for the agricultural studies to be carried out in Center of province.
35
Harwell, Carla M., Lynda N. Newman, Carolyn P. Cacho, David C. Mulligan, James A. Schulak e Miriam A. Friedlander. "Abdominal Catastrophe: Visceral Injury as a Cause of Peritonitis in Patients Treated by Peritoneal Dialysis". Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 17, n. 6 (novembre 1997): 586–94. http://dx.doi.org/10.1177/089686089701700611.
Testo completoAbstract (sommario):
Objective Peritonitis is considered an acceptable and controllable risk in patients undergoing chronic peritoneal dialysis (PD). In contrast, peritonitis due to visceralleakage represents a true “abdominal catastrophe” because of striking morbidity and mortality. To delineate the incidence, causes, and outcomes of catastrophic peritonitis, we compared patients who developed peritonitis due to documented visceral leakage with patients who developed peritonitis due to enteric organisms without evidence of visceral leakage. Design Retrospective chart review. Setting PD Unit located in tertiary care referral center. Patients 230 patients treated by PD between January 1988 and June 1996. Main Outcome Measures All episodes of PD-related peritonitis occurring over an 8-year period. Hospital course of all patients with or without renal failure who were treated at University Hospitals of Cleveland for ischemic bowel disease, cholecystitis, viscus perforation, or diverticulitis. Results Anatomically documented visceral injury caused 32.5% of episodes of enteric bacterial peritonitis in 72 patients between January 1988 and June 1996. The overall incidence of this “abdominal catastrophe” was 11.3%, or 26 of a total of 230 patients treated by PD. Of the 26 patients, 50% died, 30.7% survived but switched permanently to hemodialysis, and only 19.2% remained on, or returned to, PD. Compared to renal failure patients treated by hemodialysis or transplantation and to nonrenal failure patients, the incidence of abdominal catastrophe was 20 -60 times greater in patients treated by PD. Conclusions Evidence for injury of an abdominal organ should be sought in all patients treated by PD who develop peritonitis with enteric organisms. Surgical intervention is definitive for diagnosis, and if performed early may reduce morbidity and mortality.
36
Heng, D. Y., B. I. Rini, J. Garcia, L. Wood e R. M. Bukowski. "Durable complete responses and near complete responses to sunitinib in metastatic renal cell carcinoma". Journal of Clinical Oncology 25, n. 18_suppl (20 giugno 2007): 15514. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.15514.
Testo completoAbstract (sommario):
15514 Introduction: Sunitinib is a tyrosine kinase inhibitor with activity against VEGFR and PDGFR recently approved by the FDA for the treatment of advanced renal cell carcinoma (RCC). There is no existing literature that details complete responses (CRs) in patients taking sunitinib for metastatic RCC. Methods: Seventy-four patients with metastatic RCC receiving sunitinib at the Cleveland Clinic Taussig Cancer Center on clinical trials were reviewed to determine the number of patients with RECIST-defined CRs. Additionally, patients who achieved near-CRs defined as a greater than 90% reduction in composite tumor volume or residual disease of less than or equal to 1 cm were reviewed. Results: Two patients (2.7%) achieved a RECIST-defined CR lasting >15 months. The patients who obtained CRs had non-bulky pulmonary metastases, favorable or intermediate MSKCC risk profiles, were treated with sunitinib in the first-line setting and had a significant reduction in composite tumor measurements within the first two cycles. An additional 2 patients achieved near-CRs, including one patient that previously progressed on bevacizumab. These 2 near-CR patients remain progression-free for more than 19 months. Finally, 1 patient achieved sufficient downstaging and reduction of tumor volume such that the remaining lesion could be excised, resulting in a surgical CR. This patient is currently off sunitinib and remains progression-free 4 months after surgery. Conclusion: Sunitinib is capable of producing durable CRs in cytokine-naïve metastatic RCC patients with non-bulky pulmonary metastases. Additionally, near-CRs can be seen despite non-pulmonary metastatic sites and prior VEGF-targeted therapy. No significant financial relationships to disclose.
37
Mohammadi, Alireza Mohammad, Pablo F. Recinos, Gene H. Barnett, Robert J. Weil, Michael A. Vogelbaum, Samuel T. Chao, John H. Suh et al. "Role of Gamma Knife surgery in patients with 5 or more brain metastases". Journal of Neurosurgery 117, Special_Suppl (dicembre 2012): 5–12. http://dx.doi.org/10.3171/2012.8.gks12983.
Testo completoAbstract (sommario):
Object The authors evaluated overall survival and factors predicting outcome in patients with ≥ 5 brain metastases who were treated with Gamma Knife surgery (GKS). Methods Medical records from patients with ≥ 5 brain metastases treated with GKS between 1997 and 2010 at the Cleveland Clinic Gamma Knife Center were retrospectively reviewed. Patient demographics, tumor characteristics, treatment-related factors, and outcome data were evaluated. Results One hundred seventy patients were identified, with a median age of 58 years. The female/male ratio was 1.2:1. Gamma Knife surgery was used as an upfront treatment in 35% of patients and as salvage treatment in 65% of patients with multiple brain metastases. The median overall survival after GKS was 6.7 months (95% CI 5.5–8.1). At the time of GKS, 128 patients (75%) had concurrent extracranial metastases, and in 69 patients (41%) multiple extracranial sites were involved. Ninety-two patients (54%) had a history of whole-brain radiation therapy, and 158 patients (93%) had a Karnofsky Performance Scale (KPS) score ≥ 70. The median total intracranial disease volume was 3.2 cm3 (range 0.2–37.2 cm3). A total intracranial tumor volume ≥ 10 cm3 was observed in 32 patients (19%). Lower KPS score at the time of treatment (p < 0.0001), patient age > 60 years (p = 0.004), multiple extracranial metastases (p = 0.0001), and greater intracranial burden of disease (p = 0.03) were prognostic factors for poor outcome in the univariate and multivariate analyses. Conclusions In this study, GKS was safe and effective for upfront and salvage treatment in patients with ≥ 5 brain metastases. Gamma Knife surgery should be considered as an additional treatment modality for these patients, especially in the subset of patients with favorable prognostic factors.
38
N, Kaplan, e Caldwell J. "A-038 Aggressive Behaviors in Dementia". Archives of Clinical Neuropsychology 35, n. 6 (28 agosto 2020): 828. http://dx.doi.org/10.1093/arclin/acaa068.038.
Testo completoAbstract (sommario):
Abstract Objectives The present study investigated neural correlates of caregiver-reported aggression/agitation in older adults with memory complaints. We hypothesized that individuals rated as more aggressive/agitated would exhibit poorer executive and daily skills functioning, and show reduced volumes in brain structures implicated in aggressive behavior. Methods We examined 1207 patients (mean age = 66.91; 587 women) who completed neuropsychological evaluation at the Cleveland Clinic Lou Ruvo Center for Brain Health due to memory complaints. A subset of 252 also had brain MRI scans within six months of neuropsychological testing. Mann–Whitney and Chi Square tests examined association of caregiver-reported agitation/aggression on the Neuropsychiatric Inventory (NPI) with daily skills functioning (Activities of Daily Living Questionnaire), executive function (Delis-Kaplan Executive Function System (D-KEFS) Color-Word Inhibition (CWI), Color-Word Inhibition/Switching (CWIS), Category Switching (CS), and Trail Making Test Part IV (TMT4)), and volume or thickness of brain regions associated with developmental presentations of aggressive behavior, including the hippocampus (HC), amygdala, lateral and medial orbitofrontal cortex (OFC), frontal poles, and insula. Results Greater caregiver-reported agitation/aggression was associated with poorer multitasking (TMT4: z = −2.222, p = 0.026; CS: z = −3.014, p = 0.003), inhibition (CWI: z = −4.211, p < 0.001), and inhibition with embedded multitasking (CWIS: z = −2.898, p = 0.004). More caregiver-reported agitation/aggression also related to poorer daily skills functioning (X2(N = 1207,1) = 96.454, p < 0.001) and thinner bilateral medial OFC (Left: z = −2.040, p = 0.041; Right: z = −2.246, p = 0.025), right frontal pole (z = −2.993, p = 0.003), and right insula (z = −2.185, p = 0.029). Conclusions Present findings show similarities between cognitive and neural correlates of caregiver-reported agitated/aggressive behavior in individuals with memory concerns and individuals with developmental aggressive behavior.
39
Kwon, Seungcheol, Minjae Lee, Heeyeon Lee e Jihyo Hwang. "GS Hip Nail versus Affixus Hip Fracture Nail for the Intramedullary Nailing of Intertrochanteric Fractures". Journal of Clinical Medicine 12, n. 21 (24 ottobre 2023): 6720. http://dx.doi.org/10.3390/jcm12216720.
Testo completoAbstract (sommario):
Background: Intertrochanteric fractures are a global health concern, especially in aging populations like the Republic of Korea. Surgical treatments like intramedullary nailing are preferred for their benefit. Various hip nails are used worldwide, each with unique features and challenges. This study aims to compare the GS hip nail with the Affixus hip fracture nail for the treatment of intertrochanteric fractures. Material and Methods: This retrospective study, conducted at a single center, included 179 patients who underwent intramedullary nailing for intertrochanteric fractures using the GS hip nail or the Affixus hip fracture nail. Excluding specific cases, 43 patients in the GS group and 46 in the Affixus group met the minimum 6-month follow-up criteria. Result: The GS group exhibited a significantly shorter mean operation time (43.26 min) compared to the Affixus group (51.11 min). Radiographically, both groups showed no significant differences in their reduction quality, tip, and apex distance (TAD), or Cleveland index in the immediate postoperative window. However, the GS group achieved a greater valgus reduction based on the contralateral femoral neck shaft angle (NSA). At 6 months post-operation, there were no significant differences in TAD or advancement and sliding distances. Complication rates were similar between the two groups, with no implant breakages. Clinical outcomes, as measured via mHHS and EQ-5D-5L, showed no significant differences. Despite a slightly higher implant cost, the GS group had a lower total hospital cost than the Affixus group, but this was not statistically significant. Conclusions: This study highlights the efficiency of the GS hip nail in reducing the operation time compared to the Affixus hip fracture nail with comparable radiologic and clinical outcomes. Further research with long-term follow-up and larger patient studies are needed to fully assess its effectiveness in improving patient outcomes in hip fracture treatment.
40
Advani, Anjali, Marc Earl, Dan Douer, Michael Rytting e Archie Bleyer. "Toxicities of Intravenous (IV) Pegasparaginase (ONCASPAR®) in Adults with Acute Lymphoblastic Leukemia (ALL)." Blood 110, n. 11 (16 novembre 2007): 2811. http://dx.doi.org/10.1182/blood.v110.11.2811.2811.
Testo completoAbstract (sommario):
Abstract Background: With the multiple reports of asparaginase-containing regimens used in pediatric ALL therapy achieving a greater survival rate that non-asparaginase treatment regimens used in adult patients, asparaginase therapy is now being increasingly applied in chemotherapy regimens for adults with ALL. One reason for this resurgence is the availability of a long-acting form of the enzyme, pegylated asparaginase, and more recently, flexibility in administration of pegasparaginase via either intramuscular or intravenous routes (Oncaspar®). Given an initial impression in the 1970s that adults were more vulnerable to the toxicities of asparaginase than were children, we assessed the initial experience of intravenous asparaginase in adults with ALL. Methods: The intial experience with pegylated asparaginase at the University of Southern California (USC), Cleveland Clinic, and University of Texas M.D. Anderson Cancer Center were compiled and compared between institutions and with published results in pediatric patients. Results (Table): In 76 adult patients administered 192 doses of pegasparaginase in combination with other chemotherapy agents for ALL, hepatotoxicity was most common, with grade 3–4 elevation of serum liver enzymes and grade 3–4 hyperbilirubinemia in 36% and 14% of the patients, respectively. Hyperglycemia and chemical pancreatitis were next most common, having occurred at grade 3–4 levels in 25% and 5% of patients, respectively. Grade 3–4 toxicities in the 5–10% range were thrombosis, hypofibrinogenemia, nausea/vomiting, and fatigue. Grade 3–4 allergy/hypersensitivity, neuropathy, and CNS ischemia were reported in 1–5% of patients. Conclusions: Intravenous pegasparaginase is hepatotoxic in ∼1/3 of adult patients and has a variety of other, non-hepatic toxicities in <10% of patients, of which the most common are pancreatitis, thrombosis, nausea/vomiting and fatigue. Intravenous pegasparaginase has a toxicity profile, in combination with other chemotherapy agents used in ALL therapy, in adult patients that similar to that in pediatric patients, and warrants increased use in adult patients with ALL. Grade 3–4 Toxicities of IV Pegasparaginase in Adults USC Cleveland Clinic MD Anderson Total Median Age (Years) 28 37 20 33 Age Range (Years) 17–57 20–68 14–28 17–68 No. Doses / Patients 81 / 45 41 / 18 70 / 13 192 / 76 % Patients with Grade 3–4 Toxicity Elevated liver enzymes 31% 28% 62% 36% Hyperbilirubinemia 13% 22% 15% 14% Hyperglycemia 27% 17% 31% 25% Elevated serum amylase 0% 0%R 0% 5% Fatigue 7% 0% 0% 7% Thrombosis 4% 6% 6% 0% Hypofibrinogenemia 0% 28% 28% 0% Elevated PT/INR 0% 0% 0% 7% Bleeding 0% 0% 0% 8% Nausea/vomiting 2% 17% 17% 1% Allergy/hypersensitivity 0% 0% 0% 1% Neuropathy 2% 0% 0% 4% CNS ischemia 0% 0% 15% 3%
41
Duan, Yifei, Carlito Lagman, Raleigh Ems e Nicholas C. Bambakidis. "Relationship between middle cerebral parent artery asymmetry and middle cerebral artery aneurysm rupture risk factors". Journal of Neurosurgery 132, n. 4 (aprile 2020): 1174–81. http://dx.doi.org/10.3171/2018.12.jns182951.
Testo completoAbstract (sommario):
OBJECTIVEThe exact pathophysiological mechanisms underlying cerebral aneurysm formation remain unclear. Asymmetrical local vascular geometry may play a role in aneurysm formation and progression. The object of this study was to investigate the association between the geometric asymmetry of the middle cerebral artery (MCA) and the presence of MCA aneurysms and associated high-risk features.METHODSUsing a retrospective case-control study design, the authors examined MCA anatomy in all patients who had been diagnosed with an MCA aneurysm in the period from 2008 to 2017 at the University Hospitals Cleveland Medical Center. Geometric features of the MCA ipsilateral to MCA aneurysms were compared with those of the unaffected contralateral side (secondary control group). Then, MCA geometry was compared between patients with MCA aneurysms and patients who had undergone CTA for suspected vascular pathology but were ultimately found to have normal intracranial vasculature (primary control group). Parent vessel and aneurysm morphological parameters were measured, calculated, and compared between case and control groups. Associations between geometric parameters and high-risk aneurysm features were identified.RESULTSThe authors included 247 patients (158 cases and 89 controls) in the study. The aneurysm study group consisted of significantly more women and smokers than the primary control group. Patients with MCA bifurcation aneurysms had lower parent artery inflow angles (p = 0.01), lower parent artery tortuosity (p < 0.01), longer parent artery total length (p = 0.03), and a significantly greater length difference between ipsilateral and contralateral prebifurcation MCAs (p < 0.01) than those in primary controls. Type 2 MCA aneurysms (n = 89) were more likely to be associated with dome irregularity or a daughter sac and were more likely to have a higher cumulative total of high-risk features than type 1 MCA aneurysms (n = 69).CONCLUSIONSData in this study demonstrated that a greater degree of parent artery asymmetry for MCA aneurysms is associated with high-risk features. The authors also found that the presence of a long and less tortuous parent artery upstream of an MCA aneurysm is a common phenotype that is associated with a higher risk profile. The aneurysm parameters are easily measurable and are novel radiographic biomarkers for aneurysm risk assessment.
42
Joo, Julia H., Sanghee Hong, Lisa A. Rybicki, Betty K. Hamilton e Navneet S. Majhail. "Community Health Status and Long-Term Outcomes in 1-Year Survivors of Autologous and Allogeneic Hematopoietic Cell Transplantation". Blood 138, Supplement 1 (5 novembre 2021): 422. http://dx.doi.org/10.1182/blood-2021-148035.
Testo completoAbstract (sommario):
Abstract Background: Race/ethnicity and socioeconomic status (SES) have been associated with access to and outcomes after hematopoietic cell transplantation (HCT). The role of health disparity factors beyond race/SES in HCT outcomes, however, has not been well described. This is especially true for long-term HCT survivors, for whom local socio-demographic factors may have a greater impact on outcomes because patients may no longer be under close monitoring of their transplant center. The County Health Rankings and Roadmaps (CHRR) provides updated aggregated information from several publicly available datasets to comprehensively describe the health status of US counties. A recent report demonstrated an association between community health status and 1-year non-relapse mortality in a CIBMTR cohort of allogeneic HCT recipients (Hong et al., Cancer 2021). We conducted a single-center retrospective cohort study to investigate the association between community health and long-term outcomes in 1-year autologous and allogeneic HCT survivors. Methods: Our study included 1,812 consecutive adult patients from Cleveland Clinic's BMT Program database who received their first allogeneic or autologous HCT between 2003 and 2017 and survived at least 1 year after their transplant. We used patient community risk score (PCS) as the surrogate for community health. PCS was nationally standardized and calculated as the sum of weighted Z-scores of the 23 county-level community health factors considered in CHRR. The 23 factors fell under 4 categories of health factors: health behavior (tobacco and alcohol use, etc.), clinical care (access and quality of care), social and economic factors (education, community safety, etc.), and physical environment (environmental quality and built environment). Higher PCS indicate worse community health. We evaluated the association of PCS with overall survival (OS), relapse, and non-relapse mortality (NRM) with Cox or Fine and Gray regression separately for autologous and allogeneic HCTs. Considered co-variables included pre-transplant sociodemographic data, disease diagnosis, and transplant factors. Results: Autologous HCT recipients (n=1,313) lived in 133 of 3,141 CHRR counties, 90% in Ohio. Similarly, allogeneic recipients (n=499) were from 88 counties, 88% in Ohio. Patient characteristics are shown in Table 1. The median (range) PCS scores for autologous and allogeneic HCT recipients were 0.03 (-0.85, 0.97) and 0.03 (-0.85, 0.58), respectively. For comparison, the PCS for the complete US CHRR dataset ranged from -1.43 to 2.54 and ranged from -1.6 to 2.0 in the prior CIBMTR study that included allogeneic HCT recipients (Hong et al., Cancer 2021). PCS was not associated with OS, relapse, or NRM for autologous or allogeneic HCT recipients in univariable analysis, nor were the four categories of health factors that contribute to the total PCS (Table 2). In addition, race and estimated median household income were not associated with mortality. Similar findings were noted in multivariable analysis. Conclusion: In our single center study, PCS was not associated with OS, relapse, or NRM in allogeneic or autologous HCT recipients who survived at least 1 year after HCT. A limitation of our analysis is that our cohort represented a single center with regional representation, where long-term follow up care is provided through a dedicated survivorship clinic and there is a strong emphasis on psychosocial support. A national cohort with greater geographical diversity is needed to better define the association of community factors and outcomes in long-term HCT survivors. Figure 1 Figure 1. Disclosures Hamilton: Syndax: Membership on an entity's Board of Directors or advisory committees; Equilium: Membership on an entity's Board of Directors or advisory committees. Majhail: Anthem, Inc: Consultancy; Incyte Corporation: Consultancy.
43
Mitchell, Carley, Cheryl Apisdorf, Beth Bennett e Melinda Laine Hsu. "Cancer care beyond the clinic: An analysis of participation at The Gathering Place, a stand-alone cancer support community." Journal of Clinical Oncology 40, n. 28_suppl (1 ottobre 2022): 214. http://dx.doi.org/10.1200/jco.2022.40.28_suppl.214.
Testo completoAbstract (sommario):
214 Background: A wealth of published data exists highlighting the benefits of alternative and supportive therapies when used in combination with traditional medical approaches for individuals diagnosed with cancer. Many physical and emotional symptoms, along with quality of life, can be improved through exercise, artistic expression, mind-body practices and support group participation. While many of these services are offered through healthcare systems or large national foundations, fewer community-run organizations exist. The Gather Place (TGP) uniquely serves the Greater Cleveland area at two stand-alone locations. A wide variety of programs and services are offered, free-of-charge, to those affected by cancer. Since spring of 2020, most services have been provided virtually due to the COVID-19 pandemic. While few studies have evaluated predictors of support group utilization, there is limited data on the demographics of participants at individual support communities. Methods: De-identified, retrospective data was gathered from 04/01/2021 to 03/31/2022. Participant data including age, gender, ethnicity, residential zip code, cancer type, treatment center, date of first attendance, programs attended, and frequency of program attendance were collected and analyzed. Results: 1,494 participants with cancer utilized services at TGP with varying rates of unknown data among each category. Educational opportunities, support groups and one-on-one emotional support sessions were most frequently attended. Female involvement was greater than males (83.9% v. 15.7%), with higher participation among Caucasians compared to African Americans (79.5% v. 16.2%). 67.1% of participants resided in zip codes above the median household income of Cuyahoga County. Participants with breast and gynecologic cancers made up the majority (44.3% & 10.1%), while those with cutaneous, head/neck and hepatobiliary malignancies comprised the smallest distribution (1.6%, 1.7% & 1.8%). Conclusions: TGP is a unique organization unaffiliated with a major healthcare system providing nutrition, fitness, healing arts, education and individual/group support programs. Despite a high incidence of prostate and lung cancer diagnoses in Northeast Ohio, participants with these malignancies were a small percentage of total attendees, differing from the high disease incidence and program participation seen in patients with breast cancer. As information was gathered solely during the COVID-19 pandemic when program delivery shifted to the virtual setting, racial or income disparities reported here may reflect similar disparities seen in tele-health during the pandemic. The gaps in utilization we identified highlight opportunities for targeted areas of improved education and referral.
44
Rodriguez, Cristina, Rachid Baz, Rony Abou Jawde, Lisa Rybicki, Christopher Lowe, Matt Kalaycio, Anjali Advani, Ronald Sobecks e Mikkael A. Sekeres. "Impact of Socioeconomic Status and Distance from Treatment Center on Survival in Patients Receiving Remission Induction Therapy for Newly Diagnosed Acute Myelogenous Leukemia (AML)." Blood 108, n. 11 (16 novembre 2006): 1920. http://dx.doi.org/10.1182/blood.v108.11.1920.1920.
Testo completoAbstract (sommario):
Abstract Background: Socioeconomic status (SES) and distance from a treatment center are prognostic factors in chronic malignancies, such as head and neck or breast cancer, where relative disease latency enables patients with greater means to travel to receive their care. Little is known about the influence of these demographics on patient outcomes in rapidly-growing cancers, such as AML. Methods: We conducted a retrospective review of all patients receiving remission induction therapy for AML at the Cleveland Clinic between January 1997 and December 2005. Race and residential zipcodes were obtained from information disclosed by patients in their electronic medical records. Average annual household income in a zipcode and distance from the treatment center were obtained using web-based databases (www.melissadata.com, www.zip-codes.com). Data on known prognostic factors (age, WBC at diagnosis, cytogenetic risk groups (as defined by CALGB 8461) and AML etiology (de novo vs. secondary AML)) were collected and controlled for in multivariable analyses. Survival was estimated using the Kaplan-Meier method, and the association between distance and income assessed using the Spearman rank correlation. Results: Anthracycline-based remission induction chemotherapy was administered to 281 patients: 132 (47%) were female, with a median age at diagnosis of 60 years (range 17–80). Median WBC at diagnosis was 9.9 k/uL (range:0.4–550 k/uL). Cytogenetics were favorable in 33 patients (11.7%, 10 of whom had t(15;17)), intermediate in 137 (48.8%), unfavorable in 73 (26%), and unknown in 38 (13.5%). Ninety patients (32%) had secondary AML. The ethnic distribution was consistent with other AML series: 252 (90.6%) were Caucasian (C), 22 (7.9%) were African American (AA), and 4 (1.4%) were neither (non-AA non-C). The median distance from the treatment center was 24.4 miles (range: 0.9–2058), and median average household income was $38,972 (range: $17,496-$143,220). Overall survival (OS) was 30.2% at a median of 22.6 months of follow-up. There was no significant correlation between distance and income. In both univariable and multivariable analyses, age ≥60 years, unfavorable cytogenetics, increased WBC count at presentation and secondary AML were all found to adversely affect survival (p<0.001, p<0.001, p=0.035, and p=0.010, respectively). OS was similar for AA and non-AA non-C patients compared to C (HR=1.12 [95% CI=.61–2.07, p=.71], and HR=.87 [CI=.21–3.62, p=.84], respectively). Neither distance from treatment facility (HR=1.00 [95%CI = .98–1.02 p =.96] for every 20 mile increase in distance) nor SES (HR=1.02 [95%CI=.92–1.13, p=.77] per $10000 increase) had an impact on OS. Similar findings held for CR rates. Conclusion: Contrary to their impact on chronic malignancies, neither SES nor distance from treatment facility affect outcome in patients with AML treated at the same hospital. This supports referring patients for treatment to tertiary facilities skilled at managing AML, even when they live at great distances from those facilities.
45
Reynoso Dueñas, Jesús Jacqueline, Leticia Hernández López, Mollie Harker, Olivia Rodríguez Alcántar, Martha Cedano Maldonado, Luis Villaseñor Ibarra e José Armando Arias García. "Árboles y arbustos del Centro Universitario de Ciencias Biológicas y Agropecuarias (CUCBA) de la Universidad de Guadalajara". e-CUCBA 10, n. 19 (22 dicembre 2022): 223–42. http://dx.doi.org/10.32870/ecucba.vi19.282.
Testo completoAbstract (sommario):
An inventory of trees and shrubs in CUCBA was updated based on the work of one of the authors. For this purpose, tours werecarried out in the facilities of the University Center and thus validate the presence of the previously listed species. Thenomenclature of the taxa, their origin, and information on the presence of mistletoe and the risk status were added. A list of 214species of trees and shrubs in 148 genera of 61 families is presented. Of these, the five most diverse represent 32% of the totaland Fabaceae, Euphorbiaceae and Pinaceae stand out. The number of species added to the previous work are 95 and 51 that nolonger exist were eliminated. Sheets with photographs of some representative species are presented. Of the total species, 156are trees and 58 are shrubs, so far, the largest number of tree species recorded in the entire University Network. Regarding theorigin of the trees and shrubs, 133 are native to Mexico and the rest are introduced. Of the 133 native taxa, 97 are trees, whichalso represents the largest number of native tree species on the Network. The contribution of the Didactic Botanical Garden ofthe Institute of Botany stands out for hosting a considerable number of these native species and contributing to teaching as avaluable teaching tool. CUCBA is home to emblematic and economically important species. The percentage of species infectedby mistletoes is 15%. In terms of conservation, 16 taxa are in some risk category of the NOM-059-SEMARNAT-2010, on theIUCN Red List of threatened species 93 are registered, although only 22 present greater risk and 71 are registered in thecategory of Low Concern. In Appendix II of CITES 10 species are listed.
46
Brown, Landon C., Kunal Desai, Wei Wei, Emily N. Kinsey, Chester Kao, Daniel J. George, Brian I. Rini, Moshe C. Ornstein e Tian Zhang. "Clinical outcomes in patients with metastatic renal cell carcinoma and brain metastasis treated with ipilimumab and nivolumab". Journal for ImmunoTherapy of Cancer 9, n. 9 (settembre 2021): e003281. http://dx.doi.org/10.1136/jitc-2021-003281.
Testo completoAbstract (sommario):
The combination of ipilimumab plus nivolumab (I+N) has greatly improved outcomes in patients with intermediate or poor-risk untreated metastatic renal cell carcinoma (mRCC). However, little is known about the outcomes of patients with brain metastasis (BrM) treated with I+N. A search was performed to retrospectively identify all patients with mRCC treated with I+N in the Duke Cancer Institute and the Cleveland Clinic Taussig Cancer Center, followed by a chart review. Patients were included if they had BrM at the time of I+N initiation. Cohort characteristics are summarized with descriptive statistics. Kaplan-Meier method was used to estimate overall survival (OS) and global, intracranial, and extracranial progression-free survival (PFS) for the cohort and log rank test was used to compare OS and PFS between patient groups. Radiographic response was categorized by RECIST. Fisher’s exact test was used to correlate patient factors with radiographic response. From October 2017 to December 2020, 19 patients with BrM received I+N for mRCC with a median follow-up time of 27.1 months (range 15.0–35.6). By International Metastatic RCC Database Consortium (IMDC) risk criteria, 16% had favorable, 58% had intermediate, and 26% had poor-risk disease. 68% were systemic therapy naïve, and 77% of patients had clear cell histology. 95% had received local CNS directed therapy with surgery, radiotherapy, or both. The objective response rate was 44% (0% complete response) with three of six patients treated in the second line or greater setting experiencing a partial response. The median PFS was 7.6 months (95% CI 5.6 to 14.9). The median extracranial PFS was 8.5 months (95% CI 5.6 to 19.7), and median intracranial PFS was 14.7 months (95% CI 7.2 to not reached). No variables assessed were significantly associated with radiographic response (gender, IMDC risk, presence of bone metastasis, line of therapy, or presence of immune related adverse events). In our retrospective cohort of patients with mRCC with BrM, I+N, in combination with CNS-directed local therapy, appears to have clinical efficacy as previously described with responses seen beyond the first-line setting. Further investigation is warranted in this population given exclusion from prior clinical trials.
47
Beckermann, Kathryn, Scott Haake, Anupama Reddy, Yu Shyr, W. Kimryn Rathmell, Sumanta Pal, Moshe Ornstein, Pedro Barata, Tian Zhang e Brian Rini. "OPtimal Treatment by Invoking biologic clusters in renal cell carcinoma (OPTIC RCC)". Oncologist 28, Supplement_1 (23 agosto 2023): S14. http://dx.doi.org/10.1093/oncolo/oyad216.023.
Testo completoAbstract (sommario):
Abstract Background The first-line treatment for metastatic clear cell renal cell carcinoma (mccRCC) includes immune oncology (IO) based combination therapy. The current standard includes a PD-1 inhibitor plus either an anti-CTLA-4 inhibitor (IO/IO) or an anti-vascular endothelial growth factor receptor tyrosine kinase inhibitor (VEGF TKI) (IO/TKI). Currently, there is no evidence to guide a physician’s choice between an IO/IO versus an IO/TKI combination. The phase III IMmotion 151 trial performed RNA-seq from 823 ccRCC tumors and established seven biologically distinct gene expression clusters of ccRCC (Motzer and Rini et al., Cancer Cell 2020). The seven clusters showed differential responses to immune checkpoint inhibitor and may serve as a predictive biomarker to select clusters to assign patients with mccRCC to either an IO/IO (ipilimumab/ nivolumab) or an IO/TKI (nivolumab/cabozantinib) regimen. Methods Patients diagnosed with mccRCC without prior systemic therapy (including in the neoadjuvant or adjuvant setting) and at least one measurable lesion as defined by RECIST 1.1 are eligible for enrollment. RNA-seq will be performed on metastatic tumor specimens and used to assign tumor clusters. Patients with cluster 1/2 tumors will be assigned to the nivolumab/cabozantinib arm. Patients with cluster 4/5 tumors will be assigned to the ipilimumab/nivolumab arm. Cluster 3/6/7 will be excluded. The primary endpoint is overall response rate (ORR) per RECIST 1.1. Key secondary endpoints include progression-free survival, depth of response >80%, and rate of immune-related adverse events (irAEs). The hypothesis is that use of tumor clusters to assign front-line therapy to either nivolumab/cabozantinib or ipilimumab/nivolumab will lead to a 20% greater ORR compared to unselected historical controls in CheckMate 9ER (ORR 55%) or CheckMate 214 (ORR: 40%). This trial adopts Simon’s MiniMax two-stage design (power: 80%, one-sided alpha: 0.1). For the nivolumab/cabozantinib arm, stage I will enroll 12 eligible patients. If there are 7 or more responders in the first 12 patients, stage II will enroll an additional 14 patients (n=26). For the ipilimumab/ nivolumab arm, stage I will enroll 16 eligible patients. If there are 7 or more responders in the first 16, stage II will enroll an additional 12 patients (n=28). The primary endpoint will be met if there are 15 or more responders (ORR>60%). This trial is open and enrolling with 12 patients on study at Vanderbilt University Medical Center and additional sites to open including UT Southwestern, City of Hope, University Hospitals Seidman Cancer Center, and Cleveland Clinic. This trial is funded by the Department of Defense Kidney Cancer Research Program Clinical Trial Award (W81XWH-22-1-1033) (NCT05361720). CDMRP DOD Funding: yes
48
Tandon, Nitin, Andreas V. Alexopoulos, Ann Warbel, Imad M. Najm e William E. Bingaman. "Occipital epilepsy: spatial categorization and surgical management". Journal of Neurosurgery 110, n. 2 (febbraio 2009): 306–18. http://dx.doi.org/10.3171/2008.4.17490.
Testo completoAbstract (sommario):
Object Occipital resections for epilepsy are rare. Reasons for this are the relative infrequency of occipital epilepsy, difficulty in localizing epilepsy originating in the occipital lobe, imprecisely defined seizure outcome in patients treated with focal occipital resections in the MR imaging era, and concerns about producing visual deficits. The impact of lesion location on vision and seizure biology, the management decision-making process, and the outcomes following resection need elaboration. Methods The authors studied 21 consecutive patients who underwent focal occipital resections for epilepsy at Cleveland Clinic Epilepsy Center over a 13-year period during which MR imaging was used. Demographics, imaging, and data relating to the epilepsy and its surgical management were collected. The collateral sulcus, the border between the medial surface and the lateral convexity, and the inferior temporal sulcus were used to subdivide the occipital lobe into medial, lateral, and basal zones. Lesions that did not involve most or all of the occipital lobe (sublobar) were spatially categorized into these zones. Visual function, semiology, and scalp electroencephalography were evaluated in relation to these spatial categories. Preresection and postresection visual function and seizure frequency were evaluated and compared. Lastly, an exhaustive review and discussion of the published literature on occipital resections for epilepsy was carried out. Results Five lesions were lobar and 16 were sublobar. Patients with medial or lobar lesions had a much greater likelihood of preoperative visual field defects. Those with basal or lateral lesions had a greater likelihood of having a visual aura preceding some or all of their seizures and a trend (not significant) toward having a concordant lateralized onset by scalp electroencephalography. Invasive recordings were used in 8 cases. All patients had lesions (malformations of cortical development, tumors, or gliosis) that were completely resected, as evaluated on postoperative MR imaging. At last follow-up, 17 patients (81%) were seizure free or had only occasional auras (Wieser Class 1 or 2). The remaining 4 patients (19%) had a worthwhile improvement in seizure control (Class 3 or 4). Of the patients for whom both pre- and postoperative visual testing data were available, 50% suffered no new visual deficits, and 17% each developed a new quadrantanopia or a hemianopia. Conclusions Lesional occipital lobe epilepsy can be successfully managed with resection to obtain excellent seizure-free rates. Individually tailored resections (in lateral occipital lesions, for example) may help preserve intact vision in a subset of cases (38% in this series). Invasive recordings may further guide surgical decision-making as delineated by an algorithm generated by the authors. The authors' results suggest that the spatial location of the lesion correlates both with the semiology of the seizure and with the presence of visual deficit.
49
Sujadi, Sujadi, Tiara S. Wandita, Nanang Supena e Yurna Yenni. "GENETIC DISTANCE OF 47 ACCESSIONS OF OIL PALM (Elaeis guineensis Jacq.) GERMPLASM FROM CAMEROON BASED ON MORPHOLOGICAL CHARACTER". Jurnal Penelitian Kelapa Sawit 27, n. 1 (24 aprile 2019): 25–40. http://dx.doi.org/10.22302/iopri.jur.jpks.v27i1.70.
Testo completoAbstract (sommario):
Oil palm (Elaeis guineensis Jacq.) is a plantation commodity that has an important role in various aspects of life in Indonesia, especially the domestic economy. This is supported by the increasing demand for world palm oil for food needs (edible oil), industrial (oleochemical), and alternative energy sources based on biodiesel. The development of the palm oil industry requires several efforts to achieve increased national productivity, one of which is the utilization of quality seeds supported by the availability of genetic resources (germplasm) that have a high level of genetic diversity. Efforts that can be made for the development of oil palm in Indonesia is through the characterization of oil palm intoduction from abroad. Considering this, further research on genetic distance analysis of palm oil accession introduced from Cameroon is based on morphological characters to produce parent elders that can produce heterosis properties.
Research conducted at Seed Garden of Adolina PTPN IV and laboratory analysis of plant material of Palm Oil Research Center located on Jl. Brigjen Katamso No. 5, Medan, North Sumatera, which lasted from December 2017 to February 2018. Single observations were made on 47 accession palm oil from Cameroon planted on December 2010 and ten trees from PPKS 540 variety for compare. Data analysis used was a description of the plant to know the character of plant morphology as well as genetic distance analysis. Analysis of genetic distance using PCA analysis and cluster analysis.
The results obtained are based on the results of PCA (Principal Component Analysis) reduce the observed character into six major components that have eigen value > 1 and able to explain the material diversity tested for 73.8%. Based on the cluster analysis obtained the genetic distance of 47 accessions of palm oil from Cameroon by 57%. It can be concluded that, when the genetic distance between accessions is further away, the larger the genetic variability between the observed characters. If the genetic diversity is wider the greater the chance for successful selection in increasing the desired gene frequency.
50
Schoenfield, Lynn, Sarah Janse, David Kline, Mary E. Aronow, Arun D. Singh, Caroline Craven, Mohamed Abdel-Rahman e Colleen M. Cebulla. "Estrogen Receptor Is Expressed in Uveal Melanoma: A Potential Target for Therapy". Ocular Oncology and Pathology 7, n. 4 (2021): 303–10. http://dx.doi.org/10.1159/000512174.
Testo completoAbstract (sommario):
<b><i>Background:</i></b> Metastatic uveal melanoma (UM) has no effective treatment. To date, no publications have reported immunohistochemical evidence of estrogen receptors (ERs) in UM; however, changes in pathologic reporting for ER in breast carcinoma prompted a re-examination of ER in UM, as it could represent a potential therapeutic target. <b><i>Objective:</i></b> To determine if UM tumors express ER by immunohistochemistry (IHC) using current methodology for breast cancer and to evaluate ER gene expression using a publicly available UM database. <b><i>Methods:</i></b> A retrospective IHC analysis with clinical correlation was performed on 2 cohorts: 57 cases from the Cleveland Clinic (CC) and 50 from the Ohio State University Wexner Medical Center (OSUWMC). Analysis of The Cancer Genome Atlas Project (TCGA) UM Dataset of 80 patients was also performed. <b><i>Results:</i></b> Presence of ER was detected by IHC in 20 of 34 (59%) analyzable cases in the CC cohort. Of the 50 patients in the OSU cohort, 52 specimens from 47 patients were sufficient for analysis. Of these 47 cases, 29 (62%) had tumor that was ER positive in ≥1% nuclei. In the second cohort, positivity was classified as positive (≥10% nuclei, 34% cases) or low positive (1–9% nuclei, 28% cases). In 5 patients, there were paired samples, that is, primary tumor and subsequent recurrence or metastasis, with concordance for ER in 4 of 5 cases. In the TCGA database, elevated <i>ESR1</i> and <i>ESR2</i> gene expression was identified in a subset of UM tumors with poor genetic prognostic features. <b><i>Conclusions and Relevance:</i></b> Potentially actionable ER expression is present in greater than half of UM cases by IHC. Gene expression of <i>ESR1</i> and <i>ESR2</i> was elevated in a subset of UM tumors with poor prognostic features. These data provide a rationale to evaluate ER as a potential target for therapy in UM.