Letteratura scientifica selezionata sul tema "Fullerenoly"
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Articoli di riviste sul tema "Fullerenoly"
1
Kunkel, Marius, e Sebastian Polarz. "Easy, efficient and versatile one-pot synthesis of Janus-type-substituted fullerenols". Beilstein Journal of Organic Chemistry 15 (12 aprile 2019): 901–5. http://dx.doi.org/10.3762/bjoc.15.87.
Testo completoAbstract (sommario):
An efficient one-pot synthesis for Janus-type fullerenol derivatives and how to characterize them is reported. This synthesis provides access to asymmetrically substituted fullerenol with five substituents on one pole of the fullerene and polyhydroxylation moieties, mostly ether and hydroxy groups, on the rest of the fullerene core. As substituents a broad variety of primary amines can be used to obtain Janus-type amphiphilic fullerenols in good to excellent yield. These fullerenol amphiphiles can serve as suitable precursors for further reactions resulting in new applications for fullerenols.
2
Djordjevic, Aleksandar, Branislava Srdjenovic, Mariana Seke, Danijela Petrovic, Rade Injac e Jasminka Mrdjanovic. "Review of Synthesis and Antioxidant Potential of Fullerenol Nanoparticles". Journal of Nanomaterials 2015 (2015): 1–15. http://dx.doi.org/10.1155/2015/567073.
Testo completoAbstract (sommario):
This review describes the chemical synthesis of polar polyhydroxylated fullerene C60derivatives, fullerenols C60(OH)n,2≤n≤44, C60HzOx(OH)y, and polyanion fullerenols C60(OH)15(ONa)9, ranging from the very first synthetic methods up to some contemporary approaches to synthesis and separation. It also provides some basic information about physical characteristics of fullerenols. With the increasing number of hydroxyl groups, water solubility of fullerenols increases as well. Fullerenols both in water and biological media build nanoparticles of different dimensions and stability. In different chemical and biological model systems a large number of various polyhydroxylated fullerene derivatives were tested and they showed both their antioxidative and prooxidative characteristics. Several mechanisms have been proposed for the antioxidant activity of fullerenol. In addition, this paper also provides insight into patents referring to the antioxidant properties of fullerenol.
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Kovel, Ekaterina, Anna Sachkova, Natalia Vnukova, Grigoriy Churilov, Elena Knyazeva e Nadezhda Kudryasheva. "Antioxidant Activity and Toxicity of Fullerenols via Bioluminescence Signaling: Role of Oxygen Substituents". International Journal of Molecular Sciences 20, n. 9 (10 maggio 2019): 2324. http://dx.doi.org/10.3390/ijms20092324.
Testo completoAbstract (sommario):
Fullerenols are nanosized water-soluble polyhydroxylated derivatives of fullerenes, a specific allotropic form of carbon, bioactive compounds, and perspective basis for drug development. Our paper analyzes the antioxidant activity and toxicity of a series of fullerenols with different number of oxygen substituents. Two groups of fullerenols were under investigation: (1) C60Oy(OH)x, C60,70Oy(OH)x, where x+y = 24–28 and (2) C60,70Oy(OH)x, Fe0,5C60Oy(OH)x, Gd@C82Oy(OH)x, where x+y = 40–42. Bioluminescent cellular and enzymatic assays (luminous marine bacteria and their enzymatic reactions, respectively) were applied to monitor toxicity in the model fullerenol solutions and bioluminescence was applied as a signaling physiological parameter. The inhibiting concentrations of the fullerenols were determined, revealing the fullerenols’ toxic effects. Antioxidant fullerenol’ ability was studied in solutions of model oxidizer, 1,4-benzoquinone, and detoxification coefficients of general and oxidative types (DGT and DOxT) were calculated. All fullerenols produced toxic effect at high concentrations (>0.01 g L−1), while their antioxidant activity was demonstrated at low and ultralow concentrations (<0.001 g L−1). Quantitative toxic and antioxidant characteristics of the fullerenols (effective concentrations, concentration ranges, DGT, and DOxT) were found to depend on the number of oxygen substituents. Lower toxicity and higher antioxidant activity were determined in solutions of fullerenols with fewer oxygen substituents (x+y = 24–28). The differences in fullerenol properties were attributed to their catalytic activity due to reversible electron acceptance, radical trapping, and balance of reactive oxygen species in aqueous solutions. The results provide pharmaceutical sciences with a basis for selection of carbon nanoparticles with appropriate toxic and antioxidant characteristics. Based on the results, we recommend, to reduce the toxicity of prospective endohedral gadolinium-fullerenol preparations Gd@C82Oy(OH)x, decreasing the number of oxygen groups to x+y = 24–28. The potential of bioluminescence methods to compare toxic and antioxidant characteristics of carbon nanostructures were demonstrated.
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Sun, Hui, Jiaxin Zhang, Jianglong Kong, Hui Yuan, Yuelan Liang, Kui Chen, Xue Bai, Yanan Chang, Juan Li e Gengmei Xing. "Increased Production of Short-Chain Fatty Acids in Microbacteria Fermentation Treated by Fullerenols". Journal of Nanoscience and Nanotechnology 21, n. 10 (1 ottobre 2021): 5352–62. http://dx.doi.org/10.1166/jnn.2021.19341.
Testo completoAbstract (sommario):
Fullerenol nanoparticles were found to significantly modulate the gut microbiota and selectively enrich the short-chain fatty acids (SCFAs) production by adjusting the gut microbacteria in mice models. In this research, we screened the C. butyricum from seven strains and investigated the interactions and mechanism between the C. butyricum and fullerenol NPs in vitro fermentation. The results shows that fullerenol NPs increased the amounts of acetate and butyrate of C. butyricum without significant bacteria growth in the complete medium. The activities of the butyryl-CoA: acetate CoA transferase (BUT), which are the main pathway to produce butyrate, were reduced while the activities of the butyrate kinase (BUK) were enhanced simultaneously. Surprisingly, fullerenol NPs promoted the growth of C. butyricum and L. lactis in low glucose medium, but they could not be direct carbon source in the culture. Moreover, when cocultured with C. butyricum and the bifidobacterial strains in fullerenols, the biomass and acetate production of C. butyricum were markedly increased while butyrate was decreased significantly.
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Kuo, Wen-Shuo, Chia-Tse Weng, Jian-Hua Chen, Chao-Liang Wu, Ai-Li Shiau, Jeng-Long Hsieh, Edmund Cheung So, Po-Ting Wu e Shih-Yao Chen. "Amelioration of Experimentally Induced Arthritis by Reducing Reactive Oxygen Species Production through the Intra-Articular Injection of Water-Soluble Fullerenol". Nanomaterials 9, n. 6 (23 giugno 2019): 909. http://dx.doi.org/10.3390/nano9060909.
Testo completoAbstract (sommario):
Accumulated evidence suggests a pathogenic role of reactive oxygen species (ROS) in perpetually rheumatoid joints. Therefore, the application of radical scavengers for reducing the accumulation of ROS is beneficial for patients with rheumatoid arthritis (RA). We synthesized water-soluble fullerenols that could inhibit the production of ROS and applied intra-articular (i.a.) injection in an experimental arthritis model to examine the anti-arthritic effect of the synthesized compound. RAW 264.7 cells were used to examine the activity of the synthesized fullerenol. Collagen-induced arthritis (CIA) was induced in Sprague–Dawley rats by injecting their joints with fullerenol. The therapeutic effects were evaluated using the articular index as well as radiological and histological scores. Dose-dependent suppression of nitric oxide (NO) production caused by the fullerenol was demonstrated in the RAW 264.7 cell culture, thus confirming the ability of fullerenol to reduce ROS production. In the fullerenol-injected joints, articular indexes, synovial expression of ROS, histological and radiological scores, pannus formation, and erosion of cartilage and bone were all reduced. Moreover, interleukin (IL)-1β and vascular endothelial growth factor (VEGF) levels were reduced, and fewer von Willebrand factor (vWF)-stained areas were identified in the fullerenol-treated joints than in control joints. The i.a. injection of fullerenol for reducing ROS production can ameliorate arthritis in joints by suppressing pro-inflammatory cytokine production and the angiogenesis process. Thus, the i.a. injection of fullerenol for reducing the production of ROS can be used as a pharmacological approach for RA patients.
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Ravelo-Nieto, Eduardo, Alvaro Duarte-Ruiz, Luis H. Reyes e Juan C. Cruz. "Synthesis and Characterization of a Fullerenol Derivative for Potential Biological Applications". Materials Proceedings 4, n. 1 (11 novembre 2020): 15. http://dx.doi.org/10.3390/iocn2020-07793.
Testo completoAbstract (sommario):
Several biological barriers are generally responsible for the limited delivery of cargoes at the cellular level. Fullerenols have unique structural features and possess suitable properties for interaction with the cells. This study aimed to synthesize and characterize a fullerenol derivative with desirable characteristics (size, charge, functionality) to develop cell penetration vehicles. Fullerenol was synthesized from fullerene (C60) solubilized in toluene, followed by hydroxylation with hydrogen peroxide and tetra-n-butylammonium hydroxide (TBAH) as a phase transfer catalyst. The obtained product was purified by a Florisil chromatography column (water as the eluent), followed by dialysis (cellulose membrane dialysis tubing) and freeze-drying (yield 66%). Subsequently, a silane coupling agent was conjugated on the fullerenol surface to render free amine functional groups for further covalent functionalization with other molecules. Characterization via UV–VIS, FTIR-ATR, Raman, DLS, and SEM techniques was conducted to evaluate the composition, size, morphology, surface functionality, and structural properties. We are currently working on the conjugation of the potent cell-penetrating agents Buforin II (BUFII) and the Outer Membrane Protein A (OmpA) on the surface of the fullerenol to estimate whether cell penetration and endosome escape are improved concerning conventional polymeric vehicles and our previous developments with iron oxide nanoparticles.
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Stepin, Evsei A., Ekaterina S. Sushko, Natalia G. Vnukova, Grigoriy N. Churilov, Anastasia V. Rogova, Felix N. Tomilin e Nadezhda S. Kudryasheva. "Effects of Endohedral Gd-Containing Fullerenols with a Different Number of Oxygen Substituents on Bacterial Bioluminescence". International Journal of Molecular Sciences 25, n. 2 (5 gennaio 2024): 708. http://dx.doi.org/10.3390/ijms25020708.
Testo completoAbstract (sommario):
Gadolinium (Gd)-containing fullerenols are perspective agents for magnetic resonance imaging and cancer research. They combine the unique paramagnetic properties of Gd with solubility in water, low toxicity and antiradical activity of fullerenols. We compared the bioeffects of two Gd-containing fullerenols with a different number of oxygen groups—20 and 42: Gd@C82O20H14 and Gd@C82O42H32. The bioluminescent bacteria-based assay was applied to monitor the toxicity of fullerenols, bioluminescence was applied as a signal physiological parameter, and bacterial enzyme-based assay was used to evaluate the fullerenol effects on enzymatic intracellular processes. Chemiluminescence luminol assay was applied to monitor the content of reactive oxygen species (ROS) in bacterial and enzymatic media. It was shown that Gd@C82O42H32 and Gd@C82O20H14 inhibited bacterial bioluminescence at >10−1 and >10−2 gL−1, respectively, revealing a lower toxicity of Gd@C82O42H32. Low-concentration (10−3–10−1 gL−1) bacterial bioluminescence activation by Gd@C82O42H32 was observed, while this activation was not found under exposure to Gd@C82O20H14. Additional carboxyl groups in the structure of Gd@C82O42H32 were determined by infrared spectroscopy and confirmed by quantum chemical calculations. The groups were supposed to endow Gd@C82O42H32 with higher penetration ability through the cellular membrane, activation ability, lower toxicity, balancing of the ROS content in the bacterial suspensions, and lower aggregation in aqueous media.
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Bogdanovic, Visnja, Marija Slavic, Jasminka Mrdjanovic, Slavica Solajic e Aleksandar Djordjevic. "The activity of superoxide-dismutase in animal cell culture CHO-K1 after treatment with fullerenol and mytomicine C". Chemical Industry 63, n. 3 (2009): 143–49. http://dx.doi.org/10.2298/hemind0903143b.
Testo completoAbstract (sommario):
Eukaryotic cell survives in predominantly reduced conditions. Homeostasis of cellular redox system is an imperative of cell surviving and its normal metabolism. ROS are well recognized for playing a dual role as both deleterious and beneficial species, since they can be either harmful or beneficial to living systems. These species are mutagenic compounds known to lead to DNA damage, favor cell transformation, and contribute to the development of a variety of malignant diseases. All the effects of oxidants are influenced by the cellular antioxidant defenses. This multilayer system consists of low molecular weight components and several antioxidant enzymes. Superoxide dismutases (SODs) are the only enzymes dismuting superoxide radicals. Mitomycin C, a cross-linking agent, demonstrated genotoxicity in all in vitro and in vivo test systems in mammalian cells and animals. Water-soluble fullerenes are well known as cytotoxic agents for many cell lines in vitro. At the other side, fullerenols are good free radical scavengers and antioxidants both in vitro and in vivo. This paper investigates the effects of fullerenol on survival and fullerenol/ /mytomicine (MMC) treatment on superoxide-dismutase (SOD) activity in CHO-K1 cells. Samples were treated 3 and 24 h with fullerenol (C60(OH)24) at concentration range 0.01-0.5 mg/mL and survival was monitored with dye exclusion test (DET). The activity of total SOD was estimated in samples treated with chosen concentrations of fullerenol and MMC (0.5 and 0.1 mg/mL) after 3 and 24 h of cell incubation. Increasing of C60(OH)24 concentration leads to decreasing of percent of surviving cells 3 and 24 h after incubation. The activity of total SOD enhanced with higher concentration of fullerenol, while decreased in the highest concentration at both experimental points. In samples treated with MMC, as well as in samples treated with fullerenol (0.0625 mg/mL) + MMC was noticed boost in total SOD activity in comparison with controls. Treatment with fullerenol decreased SOD activity in rest of samples treated with MMC. Decreased activity of superoxide-dismutase in almost all samples treated with fullerenol and MMC might be contributed to antioxidative properties of fullerenol. Increased enzyme level at concentration of 0.0625 mg/mL may be due to its prooxidative activity.
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Grebowski, Jacek, Paulina Kazmierska-Grebowska, Natalia Cichon, Piotr Piotrowski e Grzegorz Litwinienko. "The Effect of Fullerenol C60(OH)36 on the Antioxidant Defense System in Erythrocytes". International Journal of Molecular Sciences 23, n. 1 (23 dicembre 2021): 119. http://dx.doi.org/10.3390/ijms23010119.
Testo completoAbstract (sommario):
Background: Fullerenols (water-soluble derivatives of fullerenes), such as C60(OH)36, are biocompatible molecules with a high ability to scavenge reactive oxygen species (ROS), but the mechanism of their antioxidant action and cooperation with endogenous redox machinery remains unrecognized. Fullerenols rapidly distribute through blood cells; therefore, we investigated the effect of C60(OH)36 on the antioxidant defense system in erythrocytes during their prolonged incubation. Methods: Human erythrocytes were treated with fullerenol at concentrations of 50–150 µg/mL, incubated for 3 and 48 h at 37 °C, and then hemolyzed. The level of oxidative stress was determined by examining the level of thiol groups, the activity of antioxidant enzymes (catalase, glutathione peroxidase, glutathione reductase, and glutathione transferase), and by measuring erythrocyte microviscosity. Results: The level of thiol groups in stored erythrocytes decreased; however, in the presence of higher concentrations of C60(OH)36 (100 and 150 µg/mL), the level of -SH groups increased compared to the control. Extending the incubation to 48 h caused a decrease in antioxidant enzyme activity, but the addition of fullerenol, especially at higher concentrations (100–150 µg/mL), increased its activity. We observed that C60(OH)36 had no effect on the microviscosity of the interior of the erythrocytes. Conclusions: In conclusion, our results indicated that water-soluble C60(OH)36 has antioxidant potential and efficiently supports the enzymatic antioxidant system within the cell. These effects are probably related to the direct interaction of C60(OH)36 with the enzyme that causes its structural changes.
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Murai, Ryota, Yasuhiro Takaya, Terutake Hayashi e Masaki Michihata. "Study on Chemical Interaction Analysis of Reactive Fullerenol Molecules in Cu-CMP Using High-Sensitive Raman Spectroscopy". Key Engineering Materials 625 (agosto 2014): 332–38. http://dx.doi.org/10.4028/www.scientific.net/kem.625.332.
Testo completoAbstract (sommario):
Surface with nanometer accuracy is required to manufacturing process of integrated circuit (IC) devices. One of the most promising techniques for surface planarization is chemical mechanical polishing (CMP). CMP is a high efficiency process, both due to the varied chemical and physical properties of the surface materials. Conventional CMP uses the slurry, which is composed of abrasive particles suspended in a chemical solution. The abrasive particle is effective for surface planarization by a chemical mechanism with little mechanical abrasion. So chemical reactivity appears to be an essential factor of CMP process. In our conventional study, fullerenols have been proposed as suitable abrasives for copper CMP. The chemical reactivity of fullerenol is suggested by the fact that high removal rate (150 nm/min) and surface flatness (0.6 nm RMS) have been confirmed using fullerenol slurry. In this study, we analyzed the chemical reactivity between fullerenol molecule and copper surface, which is important to understand the material removal mechanism. Using the intrinsic Raman spectroscopic signal of interaction between fullerenol and copper with surface plasmon resonance (SPR), the chemical reactivity over a period of the reaction process was analyzed. Raman spectroscopy is commonly used in chemical analysis, since vibrational information is specific to the chemical bonds and symmetry of molecules. Therefore, it provides a fingerprint by which the molecule can be identified. However, spontaneous Raman spectroscopic signal is typically very weak, and as a result the main difficulty of Raman spectroscopy is separating the weak inelastically scattered light from the intense Rayleigh scattered laser light. Then Raman spectroscopic signal in this study is further enhanced by the SPR, also known as surface enhanced Raman scattering (SERS). The increase in intensity of the Raman spectroscopic signal for adsorbates on copper surface occurs because of an enhancement in the electric field provided by the surface. This technique enables high-sensitive analysis in the near-surface region. The signature of copper-oxygen bond was measured by Raman spectroscopy for fullerenol/copper system by in-process SERS analysis. It is thought to be caused by the hydroxyls of fullerenol molecule adsorbed on the copper surface. This result suggests that fullerenol molecules absorbing onto the copper surface affect the high efficient material removal.
Tesi sul tema "Fullerenoly"
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Sedmidubská, Barbora. "The role of the low-energy electrons in the process of radiosensitization". Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASF069.
Testo completoAbstract (sommario):
Dans la chimioradiothérapie concomitante, il y a un effort pour augmenter son efficacité et atténuer la toxicité pour les cellules saines. Cela peut être atteint par le biais du synergisme et de la délivrance ciblée de médicaments (DCM). La DCM est un transport sélectif des médicaments vers des sites d'intérêt, protégeant ainsi les tissus sains de la toxicité des agents chimiothérapeutiques. Le synergisme est l'effet maximal de la chimioradiothérapie résultant des interactions complexes entre les deux modalités de traitement, comme l'interaction d'un agent radiosensibilisant avec des électrons de basse énergie (EBE) générés dans les tissus irradiés. Dans ce contexte, la thèse se concentre sur le processus de radiosensibilisation afin d'étudier le potentiel et les mécanismes radiosensibilisants des molécules sélectionnées basés sur leur interaction avec les EBE ; l'objectif est d'obtenir de nouvelles informations permettant de concevoir des radiosensibilisateurs plus efficaces et moins toxiques. La partie théorique traite des radiosensibilisateurs existants et leurs composés modèles du point de vue de l'interaction avec les EBE. La partie expérimentale combine des expériences d'attachement électronique en phase gazeuse et des calculs ab initio des affinités électroniques des molécules étudiées, des expériences de radiolyse pulsée en solution, ainsi que l'irradiation par microtron avec évaluation par la spectroscopie de résonance magnétique nucléaire. Sur la base de l'étude des interactions avec les EBE (secondaires), le potentiel radiosensibilisant a été confirmé pour l'agent antiviral favipiravir ; une interaction significative a été prouvée pour le radiosensibiliseur chimiothérapeutique RRx-001, ainsi qu'une forte interaction des électrons solvatés avec les fullerénols comme une plate-forme radiosensibilisante destinée à la DCMIn concomitant chemoradiotherapy (CCRT), there is an effort to increase its effectiveness and alleviate toxicity for healthy cells. It may be achieved via synergism and targeted drug delivery (TDD). TDD is the selective drug transport to sites of interest, protecting healthy tissue from chemotherapeutic toxicity. The synergism, the highest chemoradioterapeutic effect, results from complex interactions between both treatment modalities, as the interaction of the radiosensitizing chemo-drug with secondary low-energy electrons (LEEs) arising in irradiated tissue. In light of that work focuses on the radiosensitization process to investigate the radiosensitizing potential and mechanisms of selected molecules based on interaction with LEE; there is an aim to obtain new information to design more effective radiosensitizers with lower toxicity. The theoretical part deals with existing radiosensitizers and their model compounds from the point of view of interaction with LEEs. The experimental part combines electron attachment experiments in the gas phase and ab initio calculations of electron affinities of studied molecules, pulse radiolysis experiments in solution, and microtron irradiation with NMR spectroscopic evaluation. Based on the study of interaction with (secondary) LEEs, the radiosensitizing potential was confirmed for the antiviral agent favipiravir; significant interaction was proven for radiosensitizing chemotherapeutic RRx-001 as well, so as a strong interaction of solvated electrons with fullerenols as a radiosensitizing carrier drug for TGM in CCRT
Konkomitantní chemoradioterapie je jedna z důležitých metod léčby rakoviny. Stále existuje snaha zvýšit její účinnost a udržet toxicitu pro zdravé buňky na snesitelné úrovni. Její největší výhodou je synergický efekt plynoucí z mnoha komplexních interakcí mezi oběma léčebnými přístupy (tzn. chemoterapie a radioterapie). Bylo ukázáno, že jednou z příčin synergismu může být interakce chemosložky (tzv. radiosensitizéru) se sekundárními nízkoenergetickými elektrony vznikajícími v hojném počtu během radiolýzy v ozářené tkáni. V této práci se zaměřuji na proces radiosensitizace s cílem prozkoumat radiosensitizační potenciál molekul a odhalit radiosensitizační mechanismy na bázi jejich interakce s nízkoenergetickými elektrony. Motivací této práce bylo získat nové informace pro návrh nových a více účinných radiosensitizérů s menší toxicitou. Práce sestává z teoretické a experimentální části. Teoretická část je postavena na rešerši již existujících radiosensitizérů a jejich modelových sloučenin z pohledu interakce s nízkoenergetickými elektrony. Experimentální část kombinuje experimenty elektronového záchytu v plynné fázi na dvou experimentálních zařízeních, experimenty pulsní radiolýzy v roztoku, dále ozařování na mikrotronu s NMR spektroskopickým vyhodnocením a ab-initio výpočty elektronových afinit studovaných molekul a jejích fragmentů. V této práci bylo studováno antivirotikum favipiravir, pro který jsme na základě interakce s nízkoenergetickými elektrony potvrdili jeho radiosensitizační potenciál. Také byl zkoumán mechanismus radiosensitizace již potvrzeného radiosensitizéru a zároveň chemoterapeutika RRx-001 z pohledu jeho možné interakce se sekundárními nízkoenergetickými elektrony, která byla v této práci potvrzena. Nakonec byla odhalena silná interakce solvatovaných elektronů s fullerenoly studovanými pro použití v rámci platformy, která by prokazovala citlivost na nízkoenergetické elektrony a užívala by se pro dodávání léků v rámci konkomitantní chemoradiační terapii
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Bracamonte, C. Alfredo, e Ada Mayorga. "Fullerenos: la tercera forma alotrópica del carbono". Revista de Química, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/100057.
Testo completo
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Yavár, Bardavid Gastón Andrés. "Interacciones de fullereno con compósitos antiferroeléctrico polímero/monómero". Tesis, Universidad de Chile, 2014. http://repositorio.uchile.cl/handle/2250/132327.
Testo completoAbstract (sommario):
Memoria para optar al título de QuímicoSe estudiaron mezclas de tres monómeros líquidos cristalinos con fullereno: dos de ellos son azo compuestos A6OA12 y A6A12, y el tercero una imina, A11R6. No se apreció una buena miscibilidad entre dichos compuestos y fullereno utilizando técnicas de microscopia de luz polarizada y Análisis Térmico Diferencial. Un mejor resultado se obtuvo al utilizar un compósito del tipo polímero:monómero, el cual posee comportamiento antiferroeléctrico. Se obtuvieron mezclas homogéneas que fueron posteriormente dispuestas en celdas de 6,8 μm. Las celdas fueron sometidas al proceso de poling y estudiadas utilizando la técnica piroeléctrica. Las mezclas polímero:monómero con fullereno no perdieron sus propiedades antiferroeléctricas. Se observó un considerable aumento en el valor del coeficiente piroeléctrico. Este aumento se atribuye a un aumento en la absorción de luz y por tanto térmica por parte del compósito en longitudes de onda en el infrarrojo aportadas por el fullereno. Los incrementos registrados en las curvas piroeléctricas fueron más de dos veces amplificados con respecto al composito sin fullereno, a concentraciones tan baja como 2,1% en la mezcla. Es posible considerar aplicaciones de este material en sensores o para el desarrollo de celdas fotovoltaica de alta eficiencia
Mixtures of three liquid crystalline fullerene monomers were studied: two of them are azo compounds A6OA12 and A6A12, and the third one an imine, A11R6. Good miscibility between these fullerene and the monomeric compounds was not appreciated using techniques of polarized light microscopy and differential thermal analysis. A better result was obtained by using composite of polymer:monomer, which had been probed to exhibit antiferroelectric behavior. Homogeneous mixtures with fullerene were then arranged into cells of 6.8 microns. The cells were subjected to the poling process and studied using the pyroelectric technique. The mixtures polymer:monomer and fullerene did not lose its antiferroelectrics properties. A considerable increase in the value of the pyroelectric coefficient was observed. This increase is attributed to an increase in light absorption and thus heat in the composite provided by the fullerene inclusion at the near infrared. The pyroelectric curves were more than two times amplified compared with the composite without fullerene, at concentrations as low as 2.1% in the mixture. Applications as sensors of this material or for the development of high efficiency photovoltaic cells may be expected for these materials
4
Addison-Jones, Brenda. "Muon spin resonance studies of fullerenyl radicals and associated organic radicals". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0011/NQ61618.pdf.
Testo completo
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Rabinovich, Daniel. "A molecule for football fans". Revista de Química, 2016. http://repositorio.pucp.edu.pe/index/handle/123456789/99465.
Testo completoAbstract (sommario):
Una molécula para los aficionados al fútbol (El descubrimiento de los Fullerenos y su aparición en las estampillas del Reino Unido)A molecule for football fans (The discovery of fullerenes and their appearance on stamps UK)
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Hernández, Eguía Laura P. "Supramolecular chemistry of bis-porphyrins". Doctoral thesis, Universitat Rovira i Virgili, 2010. http://hdl.handle.net/10803/9059.
Testo completoAbstract (sommario):
(Base de datos de tesis doctorales TESEO) En este trabajo de tesis doctoral se desarrollan básicamente dos aspectos. El primero, es la síntesis de receptores bis-porfirínicos metalados con zinc, tanto acíclicos como cíclicos, y con diferente grado de saturación de las cadenas carbonadas, y el segundo, trata sobre los estudios de complejación llevados a cabo con ligandos de diferente tipo y propiedades: aminas y fullerenos. Los primeros se unen mediante enlaces de coordinación metal-nitrógeno, mientras que los segundos se basan en interacciones entre el anillo aromático de la porfirina y la estructura con un marcado carácter aromático de los fullerenos.
Además, se exponen los resultados obtenidos al derivar uno de los ciclopéptidos del grupo de investigación del Prof. J.R. Granja con una o dos porfirinas de zinc y emplear el ensamblaje supramolecular tipo "sándwich" entre bis-porfirinas y aminas ditópicas para controlar la mezcla regioisomérica que tiene lugar en el proceso de autoensamblaje entre los ciclopéptidos.
(Base de datos de tesis doctorales TESEO) English version
In this doctoral thesis two main aspects are developed. The first is the synthesis of bis-porphyrin receptors metallated with zinc, both acyclic and cyclic, and with different degrees of saturation of the carbon chain, and the second deals with the studies of complexation with ligands of different types and properties: amines and fullerenes. The first ligands are connected by metal-nitrogen coordination between the nitrogen of the ligand and the zinc of the porphyrin ring, while the latter are interactions between the aromatic ring of the porphyrin and the fullerenes.
In addition, we present the results obtained when derive one of the cyclopeptides of the research group of Prof. J.R. Granja with one or two zinc porphyrins, using the motif: "sandwich" complexes between bis-porphyrins and ditopic amines, in order to control the regioisomeric mixture that takes place in the self-assembly of the cyclopeptides.
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Danica, Jović. "Sinteza, karakterizacija i biološka ispitivanja fulerenol/doksorubicin nanokompozita". Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2018. https://www.cris.uns.ac.rs/record.jsf?recordId=106903&source=NDLTD&language=en.
Testo completoAbstract (sommario):
U radu je predstavljena sinteza i karakterizacija novog fulerenol/doksorubicin nanokompozita, sintetisanog sa ciljem dobijanja potencijalne nove nanoformulacije postojećeg antineoplastika doksorubicina, koja bi pokazala veću biološku aktivnost uz smanjenje neželjenih sporednih efekata koje sam lek izaziva, na prvom mestu kardiotoksičnosti.Nanokompozit fulerenol/doksorbicin je okarakterisan brojnim metodama prateći dva osnovna eksperimentalna pristupa: molekulsko-spektroskopske metode (XPS, denzitometrija i transportne osobine, NMR, UPLC, Ramanska i UV-spektroskopija, SFM) i metode nanokarakterizacije (DLS, AFM, TEM), kao i računske simulacije(RDF). Osnovni cilj ispitivanja je bila detekcija postojanja nekovalentnog nanokompozita koji ostvaruju doksorubicin i fulerenolske nanočestice u vodenom rastvoru. Rezultati karakterizacije jasno i nedvosmisleno ukazuju na postojanje nekovalentnih interakcija unutar nanokompozita, što dalje utiče na organizaciju i udruživanje čestica, a što uslovljava i drugačiju biološku aktivnost takvog sistema u odnosu na pojedinačne komponente. Rezultati bioloških ispitivanja na in vitro modelu različitih tumorskih ćelijskih linija pokazuju značajan antiproliferativni efekat nanokompozita, kao i selektivnost prema tumorskim u odnosu na zdravu ćelijsku liniju. Eksperimenti na in vivo modelu zebrica potvrđuju smanjenje toksičnosti nanokompozita u poređenju sa lekom, primarno kardiotoksičnosti. Računske simulacije, mikroskopski i spektroskopski podaci, kao i rezultati in vitro i in vivo studija ukazuju na to da nekovalentne interakcije između fulerenola i doksorubicina mogu biti ključni korak u stvaranju sinergističkog sistema za dostavu leka u biološki sistem.Multipotentnost fulerenola kao nanonosača lekova i nespecifičnost strukture doksorubicina kao leka, ukazuje na to da bi fulerenol mogao biti efikasan nanonosač i drugih antineoplastika, što daje prostora za unapređenje antitumorskih osobina lekova posredstvom istovremene administracije leka.The focus of this thesis was the synthesis and characterization of a novel fullerenol/doxorubicin nanocomposite, with the aim to obtain a potential nanoformulation of antineoplastic drug doxorubicin, which would express greater biological activity and lower level of adverse effects than the drug itself, in the first place cardiotoxicity.Nanocomposite fullerenol/doxorubicin was characterized by means of numerous methods following two main experimental approaches: molecular-spectroscopic methods (XPS, densitometry and transport properties, NMR, UPLC, Raman and UVspectroscopy, SFM) and mehods of anocharacterisation (DLS, AFM, TEM), as well as computer simulations (RDF). The goal of characterization was detection of non-covalent interactions within nanocomposite that are established between fullerenol nanoparticles and doxorubicin in aqueous solution. The results clearly indicate the existence of non- covalent interactions within nanocomposite that affect the organization and assembling of the particles, which further exhibit different biological activity of such a system in comparison to components themselves. Results of biological activity on in vitro model of different tumor cell lines show significant antiproliferative effect of nanocomposite, as well as selectivity towards tumor cell lines. Experiments conducted on in vivo zebrafish model confirm the lowering ofthe adverse effects of the drug, especially cardiotoxicity, in case when nanocomposite was applied. Computer simulations, microscopic and spectroscopic results combined with encouraging in vitro and in vivo results point out that non-covalent interactions between fullerenol nanoparticles and doxorubicin may present the keyrole in formation of a synergistic system for nanodrug delivery into biological system. Multipotential of fullerenol nanoparticles as a nanocarrier and non-specific structure of doxorubicin as a drug imply that fullerenol may serve as a efficient nanocarrier of numerous other antineoplastics, which further allows the improvement of antitumor properties of drugs withsimultaneous drug administration.
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Camafort, Blanco Berta. "Cyclotriveratrylene and Porphyrin Scaffolds for Molecular Recognition and Self-Assembly". Doctoral thesis, Universitat Rovira i Virgili, 2015. http://hdl.handle.net/10803/291439.
Testo completoAbstract (sommario):
Aquesta tesis doctoral està dividida en dues parts. La primera part de la tesi inclou el disseny, la síntesi i caracterització d’una sèrie de receptors trimèrics de porfirines així com l’estudi de la formació de complexes d’inclusió amb ful•lerens (C60, C70, C84, Sc3N@C80), nanotubs de carboni (CNT) i bucky onions.
L’objectiu principal d’aquest primer bloc és la preparació de receptors de porfirines capaços de formar, de manera selectiva o preferent, complexos d’inclusió amb ful•lerens grans (>C84) així com carbon nano onions (CNOs) i nanotubs de carboni (CNT).
En la segona part de la tesi, es detalla la síntesi i estudi de un monòmer piramidal amb estructura central de CTV quiral connectada a llargues cadenes alquíliques a través d’enllaços d’urea.
L’objectiu principal d’aquest segon bloc és la preparació d’un monòmer de CTV capaç d’ampliar tal quiralitat del monòmer a l’estructura supramolecular. Per tal de promoure aquest comportament, els monòmers van ser previstos de urees que degut a la seva habilitat per establir ponts d’hidrogen d’especificitat i direccionalitat alta promourien la formació d’una hèlix macroscòpica.Esta tesis doctoral está dividida en dos partes. La primera parte de la tesis incluye el diseño, síntesis y caracterización de una serie de receptores trimericos de porfirinas así como el estudio de la formación de complejos de inclusión con fulerenos (C60, C70, C84, Sc3N@C80), nanotubos de carbono (CNT) y bucky onions. El objetivo principal de este primer bloque es la preparación de los receptores de porfirinas capaces de formar de manera selectiva o preferente, complejos de inclusión con fulerenos grandes (>C84) así como carbon nano onions (CNOs) y nanotubos de carbono (CNT). En la segunda parte de la tesi se detalla la síntesis y estudio de un monómero piramidal con estructura central de CTV quiral conectada a largas cadenas alquílicas a través de enlaces tipo urea. El objetivo principal de este segundo bloque es la preparación de un monómero capaz de ampliar tal quiralidad a la estructura supramolecular. Para promover tal comportamiento, los monómeros son provistos de ureas que debido a su habilidad para establecer puentes de hidrogeno de alta especificidad y direcctionalidad promoverian la formación de una hélice macroscópica.
This thesis is divided in two different parts. The first part includes the design, synthesis and characterization of a series of porphyrin trimeric receptors as well as the study of the inclusion complex formation with fullerenes (C60, C70, C84, Sc3N@C80), carbon nanotubes (CNT) and bucky onions. The main objective of this first bloc is the preparation of porphyrin-based receptors able to selectively encapsulate big fullerenes (>C84) as well as carbon nano onions (CNOs) and carbonnanotubes (CNT). The second part of the thesis deals with the synthesis and studies of a chiral pyramidic monomer bearing a CTV central core connected to long alkyl chains through urea type linkers. The objective of this second block would be the preparation of a CTV-monomer able to transfer the chirality from the CTV central core to the supramolecular column. To promote such behavior, the monomers are provided with urea moieties that due to their high specificity and directionality would promote de formation of the macroscopic helix.
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Vásquez, Aquino Diana Emperatriz. "Efectos del fulereno C60 y cobre mediados por luz UV-VIS en Daphnia magna en condiciones de laboratorio". Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2014. https://hdl.handle.net/20.500.12672/3722.
Testo completoAbstract (sommario):
En los últimos años ha surgido una nueva tecnología en el rango nanométrico denominado hoy en día Nanotecnología. Desde su descubrimiento, la producción y uso de nanomateriales se ha visto incrementado rápidamente. Uno de ellos es el Fulereno (C60), el cual es utilizado en diferentes campos de la ciencia y la tecnología como la medicina, cosmética, electricidad, entre otros. Esta nueva industria genera desechos de producción que tienen como destino final los ambientes acuáticos, del mismo modo los residuos del uso de productos que contienen nanomateriales como los son algunos detergentes, bloqueadores solares, desodorantes. Como es sabido los ambientes acuáticos son dinámicos y conformados por múltiples componentes. Sin embargo, no se han realizado suficientes evaluaciones de los posibles efectos de la exposición de dicho compuesto en el ambiente y por ende, en los organismos, más aún, la interacción del mismo con otros contaminantes de origen natural o artificial.
El presente estudio fue realizado con el fin de evaluar la influencia de un nanocompuesto denominado Fulereno (C60) sobre un organismo acuático denominado Daphnia magna, mediado por dos factores adicionales: un metal (Cobre) y la luz ultravioleta en condiciones de laboratorio. Para ello, se obtuvieron “dafnias” que posteriormente fueron reproducidas considerando 16h luz/ 8h oscuridad y una alimentación en base a Nutrafiin basic (3g) suplementado con levadura (0.05g).
Luego del cultivo, se sometió a los organismos juveniles de Daphnia magna, a diferentes tratamientos durante 48 hrs., luego de los cuales se evaluó lo siguiente: 1) DL50 y la EC50 en diferentes concentraciones de Fulereno (C60) y Cobre; 2) El grado de estrés oxidativo generado por una gradiente de concentraciones de Fulereno (C60) y Cobre; 3) Evaluar su comportamiento considerando la frecuencia de saltos por minuto ante la exposición a diferentes concentraciones y bajo la influencia de luz UV (pre y post); y, 4) Evaluar la producción de melaninas como respuesta a la exposición de Fulereno C60 y Cobre a diferentes concentraciones y bajo la influencia de luz UV (pre y post). Esto permitió estimar el riesgo ambiental del fulereno aunado a contaminantes clásicos como un metal (Cobre) y la luz UV, a fin de proponer posibles mecanismos de acción.
Los resultados muestran que no hay diferencias estadísticamente significativas en cuanto a capacidad antioxidante entre un pre y post tratamiento con luz UV-Vis, sin embargo sí existen diferencias a nivel comportamental (frecuencia de saltos) y entre la cantidad de melaninas generadas entre ambos tratamientos considerando la mezcla de Fulereno C60 y Cobre, y la pre y post exposición a radiación UV.In recent years there has emerged a new technology in the nanometer range today called Nanotechnology. Since its discovery, production and use of nanomaterials has been increased rapidly. One is the Fullerene (C60), which is used in different fields of science and technology such as medicine, cosmetics, electricity, among others. This new industry generates waste production are destined for aquatic environments, just as the use of waste products containing nanomaterials as are some detergents, sunscreens, deodorants. As is well known aquatic environments are dynamic and shaped by multiple components. However, there have been sufficient assessments of the potential effects of exposure to this compound in the environment and therefore, in organisms, even more, its interaction with other pollutants of natural or artificial origin. This study was conducted in order to evaluate the influence of a nanocomposite called Fullerene (C60) on a water body called Daphnia magna, mediated by two other factors: a metal (copper) and the ultraviolet light in the laboratory. To do this, “daphnia” which were subsequently reproduced considering 16h light / 8h dark and feeding based on basic Nutrafiin (3g) supplemented with yeast (0.05g) was obtained. After the culture was subjected to youth organizations Daphnia magna, to different treatments for 48 h, after which the following were evaluated: 1) LD50 and EC50 in different concentrations of Fullerene (C60) and Copper; 2) The degree of oxidative stress generated by a concentration gradient of fullerene (C60) and Copper; 3) Assess their behavior considering the frequency of jumps per minute when exposed to different concentrations and under the influence of UV light (pre and post); and 4) Evaluate the production of melanin in response to exposure of fullerene C60 and copper at different concentrations and under the influence of UV light (pre and post). This allowed us to estimate the environmental risk of fullerene contaminants coupled with classics like a metal (copper) and UV light in order to propose possible mechanisms of action. The results show no statistically significant differences in antioxidant capacity between before and after treatment with UV -Vis light, however there are differences at the behavioral level (frequency hopping) and between the amount of melanin generated between both treatments considering fullerene C60 mixture and Copper, and pre and post exposure to UV radiation. Keywords: Fullerene (C60), Copper, antioxidant capacity, frequency jumps, Melanin.
Tesis
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Abella, Guzman Laura. "Computations on Fullerenes: Characterization, Reactivity and Growth". Doctoral thesis, Universitat Rovira i Virgili, 2017. http://hdl.handle.net/10803/460692.
Testo completoAbstract (sommario):
Aquesta Tesi titulada ‘Computations on Fullerenes: Characterization, Reactivity and Growth’ es focalitza amb els mecanismes de formació i caracterització de ful·lerens prèviament detectats als experiments. Són caixes tancades de carboni formades per hexàgons i dotze pentàgons. Hem col·laborat amb diferents grups experimentals, per tant, ens hem centrat en entendre i racionalitzar els seus experiments. Diferents models de formació de ful·lerens han estat proposats, però encara avui segueix sent un misteri. Els nostres estudis donen completament suport al mecanisme de creixement bottom-up proposat pel Prof. Kroto. Aquest mecanisme ha estat estudiat per càlculs estàtics de DFT i per dinàmica molecular de Car-Parrinello. Una exploració exhaustiva dels isòmers més favorables, així com les superfícies d’energia potencial associades a les insercions d’unitats C2 als ful·lerens i les topologies de les estructures involucrades, han ajudat al desenvolupament d’aquest projecte. Aquest procés d’inserció és exotèrmic/exergònic, i encara que les barreres d’energia lliure són elevades, es poden veure superades a la temperatura de formació de ful·lerens (2000 K). Els isòmers més abundants del Ti@C2n (2n=26-48) i Sc3N@C2n (2n=68-80) s’han relacionat mitjançant unitats C2 i, en alguns casos, alguna isomerització del tipus Stone-Wales. Respecte a la detecció i aïllament dels metal·loful·lerens endoèdrics, ens hem centrat en la seva caracterització. La cloració dels ful·lerens també ha estat estudiada, ja que ha sorgit com una poderosa eina en el món dels derivats de ful·lerens. Famílies de C2n (2n=50,60,66,68,etc.) han estat trobades com cloroful·lerens. Els nostres resultats prediuen que la cloració s’esdevé un cop es formada la caixa neutra a temperatures més baixes de 2000 K, mitjançant l’addició de radical lliure i tenint en compte les distribucions del HOMO i de la densitat d’spin. La majoria dels nostres projectes han estat d’acord amb els resultats experimentals.La Tesis titulada ‘Computations on Fullerenes: Characterization, Reactivity and Growth’ se focaliza con los mecanismos de formación y caracteritzación de fullerenos previamente detectados a los experimentos. Son cajas cerradas de carbono formadas por hexágonos y doce pentágonos. Hemos colaborado con diferentes grupos experimentales, por tanto, nos hemos centrado en entender y racionalizar sus experimentos. Diferentes modelos de formación han sido propuestos, pero todavía hoy sigue siendo un misterio. Nuestros estudios dan soporte al mecanismo de crecimiento bottom-up propuesto por el Prof. Kroto. Este mecanismo ha sido estudiado mediante cálculos estáticos de DFT i por dinámica molecular de Car-Parrinello. Una exploración exhaustiva de los isómeros más favorables, así como las superficies de energía potencial asociadas a las inserciones de unidades C2 a los fullerenos y las topologías de las estructures involucradas, han ayudado al desarrollo de este proyecto. Este proceso de inserción es exotérmico/exergónico, y todavía que las barreras de energía libre son elevadas, se pueden ver superadas a la temperatura de formación de fullerenos (2000 K). Los isómeros más abundantes del Ti@C2n (2n=26-48) y Sc3N@C2n (2n=68-80) se han relacionado mediante unidades C2 y, en algunos casos, alguna isomerización del tipo Stone-Wales. Respecto a la detección y aislamiento de los metallofullerenos endoédricos, nos hemos centrado en su caracteritzación. La cloración de los fullerenos también ha sido estudiada, ya que ha surgido como una poderosa herramienta en el mundo de los derivados de fullerenos. Familias de C2n (2n=50,60,66,68,etc.) han sido encontradas como clorofullerenos. Nuestros resultados predicen que la cloración se forma una vez es formada la caja neutra a temperaturas más bajas de 2000 K, mediante la adición de radical libre y teniendo en cuenta las distribuciones del HOMO y de la densidad de espín. La mayoría de nuestros proyectos han estado de acuerdo con los resultados experimentales.
The Thesis titled ‘Computations on Fullerenes: Characterization, Reactivity and Growth’ is mainly focused on the formation mechanisms and characterization of fullerenes previously detected in experiments. These molecules are closed carbon cages formed by only hexagons and twelve pentagons. Most part of our research has been carried out in collaboration with different experimental groups, therefore we aimed to understand and rationalize their experiments. Although many hypothetical models have been proposed, the fullerene formation mechanism is still a mystery. Our studies rules out the bottom-up mechanism as a model of fullerene formation. We have explored this mechanism by means of static DFT and Car-Parrinello molecular dynamics calculations for series of different endohedral fullerenes. A comprehensive exploration of the most favourable isomers, potential energy surfaces associated with the successive C2 insertions and topologies of the involved structures, helped us to develop this project. The insertion of a C2 unit to already formed EMF is always an exothermic/exergonic process, and the free energy barriers for each step are attainable at temperature of fullerene formation (2000 K). The most abundant isomers of Ti@C2n (2n=26-48) and Sc3N@C2n (2n=68-80) are formally linked by direct C2 insertions and in a few cases by additional Stone-Wales transformations. Regarding the detection and isolation of endohedral metallofullerenes let us to perform a computational study of the rationalization and characterization of these isomers. Chlorination has emerged as a powerful tool in fullerene derivatives. Several C2n families (2n=50,60,66,68,etc.) have been found to show cages exohedrally chlorinated. According to our results, chlorination would take place at a temperature significantly lower than 2000 K by free radical addition considering the HOMO and the spin density distributions of the pristine cage and intermediates, once the lowest energy neutral isomers are formed. Most of our projects resulted in suitable and in agreement with experiments.
Libri sul tema "Fullerenoly"
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Zakirnichnai︠a︡, M. M. Obrazovanie fullerenov v uglerodistykh stali︠a︡kh i chugunakh pri kristallizat︠s︡ii i termicheskikh vozdeĭstvii︠a︡kh. Ufa: Gilem, 2002.
Cerca il testo completoCapitoli di libri sul tema "Fullerenoly"
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Injac, Rade, Matevz Prijatelj e Borut Strukelj. "Fullerenol Nanoparticles: Toxicity and Antioxidant Activity". In Oxidative Stress and Nanotechnology, 75–100. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-475-3_5.
Testo completo
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Trajković, S., S. Dobrić, A. Djordjević, V. Dragojević-Simić e Z. Milovanović. "Radioprotective Efficiency of Fullerenol in Irradiated Mice". In Materials Science Forum, 549–54. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-971-7.549.
Testo completo
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Krokosz, Anita, e Jacek Grebowski. "Activity of Membrane ATPases in Human Erythrocytes Under the Influence of Highly Hydroxylated Fullerenol". In Regulation of Membrane Na+-K+ ATPase, 159–72. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-24750-2_9.
Testo completo
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Yadav, Divyansh, e Seema Nara. "Nanozymes for Neurodegenerative Diseases". In Proceedings of the Conference BioSangam 2022: Emerging Trends in Biotechnology (BIOSANGAM 2022), 77–95. Dordrecht: Atlantis Press International BV, 2022. http://dx.doi.org/10.2991/978-94-6463-020-6_9.
Testo completoAbstract (sommario):
AbstractNeurodegenerative diseases are incurable diseases that get worse as time passes. These diseases are very heterogeneous in nature but have common characteristics like abnormal deposition of protein, glycation, inflammation in particular areas of the brain, and progressive neuronal loss due to oxidative stress. Among these, oxidative stress alone causes a high level of degeneration of neurons. To reduce oxidative stress, natural antioxidants are used but they have some drawbacks like instability, high cost and low reusability. To overcome this, nanozymes are introduced and we have emphasized on major nanozymes whose antioxidant capability has been proven which are gold nanozymes, fullerene, nanoceria, and quantum dots. Gold nanoparticles and their conjugates with other molecules can mimic the enzymatic activity of superoxide dismutase and catalase which decrease the amount of hydrogen peroxide and superoxide radicals in cells. Gold Nanozyme treatment reduces the oxidative stress, nitrite, and sulfhydryl levels in the brain and also rectifies the superoxide dismutase, glutathione, and catalase activity levels. Fullerenols has shown superoxide dismutase activity which was 268 times more effective than mannitol and 37 times more effective than Vitamin E for lipid radicals. Nanoceria has the ability to mimic Superoxide Dismutase as well as catalase activity, can also detoxify peroxynitrite. Quantum dots (QDs) like Graphene Oxide QDs can scavenge the reactive oxygen species and also show indirect activity which alleviates the pathogenesis of the disease. Thus, a nanozyme can be used as an efficient nanomedicine if it is tailored to possess high catalytic activity while eliminating all complications.
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Kojić, V., D. Jakimov, G. Bogdanović e A. Djordjević. "Effects of Fullerenol C60(OH)24 on Cytotoxicity Induced by Antitumor Drugs on Human Breast Carcinoma Cell Lines". In Materials Science Forum, 543–48. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-971-7.543.
Testo completo
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Miguel del Carmen, DOMINGUEZ-TRUJILLO, MARTINEZ-VARGAS Sergio, SIERRA-GRAJEDA Juan Manuel Tadeo e MANDUJANO-RAMIREZ Humberto Julián. "Estudio de la adsorción de CO2 en fullereno C20 usando la Teoría del Funcional de la Densidad". In Handbook Ingeniería y Materiales Aplicados al Medio Ambiente TI, 94–107. ECORFAN, 2022. http://dx.doi.org/10.35429/h.2022.9.94.107.
Testo completoAbstract (sommario):
En este trabajo de investigación se presenta el estudio de la interacción intermolecular de estructuras de fullereno prístino (C20) y dopado con aluminio (C19Al) con dióxido de carbono (CO2). Se diseñaron las estructuras del fullereno y se optimizaron con los funcionales B3LYP, PBE y ωB97X-D3 y el conjunto de bases 6-31G(d,p), y se determinaron la energías de adsorción de CO2 en ambas estructuras, C20 y C19Al. Los resultados revelan que la adsorción del CO2 es mayor con el fullereno dopado con aluminio (C19Al) con respecto a la adsorción del fullereno prístino (C20), demostrando el potencial del fullereno C19Al para emplearse como adsorbente selectivo en sensores de CO2. Para mejorar la precisión de las energías de adsorción de los sistemas (C20-CO2 y C19Al-CO2), se calculó la corrección por Error de Superposición del Conjunto Base o BSSE (del inglés Basis Set Superposition Error).
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Taylor, Roger. "Radical Additions to Fullerenes: Fullerenyl Radicals". In The Chemistry of Fullerenes, 211–19. WORLD SCIENTIFIC, 1995. http://dx.doi.org/10.1142/9789812386250_0013.
Testo completo
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Sánchez-Bernabe, Francisco Javier. "UNA INTRODUCCIÓN A LA MODELACIÓN DE FULLERENOS". In Ciencias exactas y de la tierra: Observación, formulación y predicción 2, 106–11. Atena Editora, 2022. http://dx.doi.org/10.22533/at.ed.83722170512.
Testo completo
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Kokubo, Ken. "Water-Soluble Single-Nano Carbon Particles: Fullerenol and Its Derivatives". In The Delivery of Nanoparticles. InTech, 2012. http://dx.doi.org/10.5772/36352.
Testo completo
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Martínez-González, J., A. Flores Gil, D. Reyes-Contreras, Enrique Vigueras Santiago e I. García-Orozco. "Síntesis de nanoestructuras de carbono por molienda mecánica". In Materiales Avanzados y Nanomateriales: Aprovechamiento de fuentes naturales y sus beneficios al medio ambiente, 201–38. OmniaScience, 2022. http://dx.doi.org/10.3926/oms.409.08.
Testo completoAbstract (sommario):
Los nanomateriales de carbono como son los tubos, los puntos cuánticos, el grafeno, los fullerenos, entre otros, tienen gran importancia tecnológica por sus propiedades, eléctricas y ópticas, así como por la formación de materiales compuestos con propiedades mecánicas mejoradas. Por mucho tiempo los nanomateriales han sido preparados por diversas rutas, tanto físicas como químicas. En este trabajo se presenta a la molienda mecánica como una técnica adecuada para la generación de nanomateriales de carbono. En este capítulo se describen los fundamentos teóricos y los detalles técnicos de la molienda mecánica involucrados en la obtención de nanomateriales. Adicionalmente se presenta la obtención de nanopartículas de carbono utilizando electrodos de pilas recuperadas, a través de molienda mecánica de alta energía.
Atti di convegni sul tema "Fullerenoly"
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Grabovoy, A. S., O. V. Kolesnik e N. S. Kudryasheva. "STUDY OF THE RADIOPROTECTIVE PROPERTIES OF FULLERENOL C60,70 USING BACTERIAL LUMINESCENT BIOASSAY". In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-172.
Testo completoAbstract (sommario):
Radioprotective properties of fullerenol C60,70 were studded using bacterial luminescent bioassay. The results of experiments showed: an activation of bioluminescence by tritium, mitigation of tritium effect by fullerenol, 20 % increase of reactive oxygen species under exposure to fullerenol.
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Ryabokon, I. S., V. P. Sedov, P. L. Molkanov, D. N. Orlova, M. V. Suyasova e M. E. Vznuzdaev. "STUDY OF THE POSSIBILITY OF SYNTHESIS OF ENDOHEDRAL TELLURIUM FULLERENES". In NOVEL TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY, 87–91. LLC Institute Information Technologies, 2024. http://dx.doi.org/10.47501/978-5-6044060-4-5.87-91.
Testo completoAbstract (sommario):
The article discuss the possibility of synthesizing endohedral fullerens (endofullerens) of tellurium and converting them into a water-soluble form with the aim of subsequently obtaining endohedral fullerenols of iodine by irradiation with thermal neutrons. An experimental method for producing tellurium endofullerene, converting it into a water-soluble form, and studying the properties of the resulting product using spectroscopic methods is described.
3
Sadretdinova, Zarema R., Arslan R. Akhmetov, Lilya U. Dzhemileva, Vladimir A. D’yakonov, Airat Tuktarov e Usein Dzhemilev. "Fullerenyl-1,2,3-Triazoles: Synthesis and Cytotoxic Activity". In ECSOC-25. Basel Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/ecsoc-25-11659.
Testo completo
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Liu, Jinyun, Zuobin Wang, Yingmin Qu, Guoliang Wang, Dayou Li e Carsten Maple. "Effect of fullerenol on the morphology features of SW480 cells". In 2013 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale (3M-NANO). IEEE, 2013. http://dx.doi.org/10.1109/3m-nano.2013.6737383.
Testo completo
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Nepomnyashchaya, Elina, Ekaterina Savchenko, Elena Velichko e Evgenij Aksenov. "Interaction of fullerenol with metals: the research by laser correlation spectroscopy". In Saratov Fall Meeting 2016: Fourth International Symposium on Optics and Biophotonics, a cura di Valery V. Tuchin, Elina A. Genina, Dmitry E. Postnov e Vladimir L. Derbov. SPIE, 2017. http://dx.doi.org/10.1117/12.2269819.
Testo completo
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Vachugova, Ekaterina, Ekaterina Savchenko e Elina Nepomnyashchaya. "Investigation of the fullerenol solution parameters by combined technique based on light scattering". In 2020 International Conference on Information Technology and Nanotechnology (ITNT). IEEE, 2020. http://dx.doi.org/10.1109/itnt49337.2020.9253329.
Testo completo
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Kyokane, J., N. Tsujimoto, M. Ishida e M. Fukuma. "Space charge characteristics of fullerenol and carbon nanotube doped polyurethane elastomer (PUE) actuators". In Proceedings of 2005 International Symposium on Electrical Insulating Materials, 2005. (ISEIM 2005). IEEE, 2005. http://dx.doi.org/10.1109/iseim.2005.193391.
Testo completo
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Karpunin, A. E., V. I. Gerasimov, A. S. Mazur, I. V. Pleshakov, Ya A. Fofanov e O. V. Proskurina. "NMR Investigation of Composite Material, Formed by Fullerenol in Polymer Matrix of Polyvinyl Alcohol". In 2018 IEEE International Conference on Electrical Engineering and Photonics (EExPolytech). IEEE, 2018. http://dx.doi.org/10.1109/eexpolytech.2018.8564390.
Testo completo
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Wang, Min, Ying-Ying Huang, Liyi Huang, Tianhong Dai, Michael R. Hamblin e Long Chiang. "Decacationic [70]fullerenyl-light harvesting chromophore conjugates for efficient photokilling of infectious bacteria (Conference Presentation)". In Photonic Diagnosis and Treatment of Infections and Inflammatory Diseases, a cura di Tianhong Dai. SPIE, 2018. http://dx.doi.org/10.1117/12.2289070.
Testo completo
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Jeon, Seaho, Min Wang, Taizoon Canteenwala, Loon-Seng Tan, Wei Ji, Thomas Cooper e Long Chiang. "Synthesis of dual NIR two-photon absorptive [60]fullerenyl multiadducts for nonlinear light-transmittance reduction application". In SPIE Organic Photonics + Electronics, a cura di Jean-Michel Nunzi. SPIE, 2014. http://dx.doi.org/10.1117/12.2060935.
Testo completoRapporti di organizzazioni sul tema "Fullerenoly"
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Long, Chiang. Ultrafast Photoresponsive Starburst and Dendritic Fullerenyl Nanostructures for Broadband Nonlinear Photonic Material Applications. Fort Belvoir, VA: Defense Technical Information Center, agosto 2014. http://dx.doi.org/10.21236/ada608881.
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