Letteratura scientifica selezionata sul tema "Extracellular HSP27"
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Articoli di riviste sul tema "Extracellular HSP27":
Stope, Matthias B., Gerd Klinkmann, Karoline Diesing, Dominique Koensgen, Martin Burchardt e Alexander Mustea. "Heat Shock Protein HSP27 Secretion by Ovarian Cancer Cells Is Linked to Intracellular Expression Levels, Occurs Independently of the Endoplasmic Reticulum Pathway and HSP27’s Phosphorylation Status, and Is Mediated by Exosome Liberation". Disease Markers 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/1575374.
Winter, Julia, Elke Hammer, Jacqueline Heger, Heinz-Peter Schultheiss, Ursula Rauch, Ulf Landmesser e Andrea Dörner. "Adenine Nucleotide Translocase 1 Expression Is Coupled to the HSP27-Mediated TLR4 Signaling in Cardiomyocytes". Cells 8, n. 12 (6 dicembre 2019): 1588. http://dx.doi.org/10.3390/cells8121588.
Gabai, Vladimir L., e Michael Y. Sherman. "Invited Review: Interplay between molecular chaperones and signaling pathways in survival of heat shock". Journal of Applied Physiology 92, n. 4 (1 aprile 2002): 1743–48. http://dx.doi.org/10.1152/japplphysiol.01101.2001.
Singer, Debora, Can Pascal Wulff, Matthias B. Stope e Sander Bekeschus. "Extracellular Heat Shock Protein 27 Is Released by Plasma-Treated Ovarian Cancer Cells and Affects THP-1 Monocyte Activity". Plasma 5, n. 4 (6 dicembre 2022): 569–78. http://dx.doi.org/10.3390/plasma5040040.
Grotegut, Pia, Sandra Kuehn, H. Burkhard Dick e Stephanie C. Joachim. "Destructive Effect of Intravitreal Heat Shock Protein 27 Application on Retinal Ganglion Cells and Neurofilament". International Journal of Molecular Sciences 21, n. 2 (15 gennaio 2020): 549. http://dx.doi.org/10.3390/ijms21020549.
Sevin, Margaux, Nicolas Pernet, Franck Vitte, Selim Ramla, Paul Sagot, Laurent Martin, Jean Luc Villeval et al. "HSP27: A Therapeutic Target in Myelofibrosis". Blood 128, n. 22 (2 dicembre 2016): 1963. http://dx.doi.org/10.1182/blood.v128.22.1963.1963.
Grotegut, Pia, Philipp Johannes Hoerdemann, Sabrina Reinehr, Nupur Gupta, H. Burkhard Dick e Stephanie C. Joachim. "Heat Shock Protein 27 Injection Leads to Caspase Activation in the Visual Pathway and Retinal T-Cell Response". International Journal of Molecular Sciences 22, n. 2 (6 gennaio 2021): 513. http://dx.doi.org/10.3390/ijms22020513.
Bitar, K. N., A. Ibitayo e S. B. Patil. "HSP27 modulates agonist-induced association of translocated RhoA and PKC-α in muscle cells of the colon". Journal of Applied Physiology 92, n. 1 (1 gennaio 2002): 41–49. http://dx.doi.org/10.1152/jappl.2002.92.1.41.
Musiał, Kinga, e Danuta Zwolińska. "Extracellular Hsp27 in patients with chronic kidney disease". Kidney International 83, n. 5 (maggio 2013): 971. http://dx.doi.org/10.1038/ki.2013.33.
Hatakeyama, Daijiro, Osamu Kozawa, Masayuki Niwa, Hiroyuki Matsuno, Kanefusa Kato, Norichika Tatematsu, Toshiyuki Shibata e Toshihiko Uematsu. "Inhibition by adenylyl cyclase-cAMP system of ET-1-induced HSP27 in osteoblasts". American Journal of Physiology-Endocrinology and Metabolism 281, n. 6 (1 dicembre 2001): E1260—E1266. http://dx.doi.org/10.1152/ajpendo.2001.281.6.e1260.
Tesi sul tema "Extracellular HSP27":
Williams, Helen. "Interactions between extracellular Hsp72 and blood cells". Thesis, University of Chester, 2010. http://hdl.handle.net/10034/277691.
Tsai, Tsen-Ni, e 蔡甄妮. "The role of extracellular Hsp72 during sepsis". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/g5c8ft.
高雄醫學大學
醫學研究所博士班
103
Background: Sepsis, the leading cause of death in intensive care units, annually affects more than 500,000 patients in the United States; despite advances in treatment and supportive care, the mortality rate remains higher than 20%. Our previous study revealed that heat shock reduces the sepsis-related mortality rate by increasing the expression of heat shock protein 72 (Hsp72, also known as Hp70). Hsp72, a molecular chaperone intracellularly induced by stress, exhibits antiinflammatory and antiapoptotic effects. Hsp72 protects cells and is released into the circulation by various cells in response to stress and toxic treatments. However, the precise role of extracellular Hsp72 (eHsp72) during sepsis remains unclear . The present study was divided into two parts; the first part was conducted to clarify the effect of eHsp72 on the sepsis-related survival rate and to determine the underlying factors. The second part was conducted to assess the hypothesis that eHsp72 is involved in reversing sepsis-induced liver dysfunction. Methods: Part 1: Sepsis was induced by cecal ligation and puncture (CLP). Changes in serum levels of Hsp72 and cytokines were determined during sepsis, and the results were correlated with the survival rate. The effects of heat pretreatment on Hsp72 expression in septic rat leukocytes and those of septic rat serum, lipopolysaccharide (LPS), and certain cytokines on Hsp72 expression in macrophage NR8383 cells were 7 determined. Part II: Liver function was determined on the basis of changes in the enzymatic activities of serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT). Apoptosis was measured using terminal deoxynucleotidyl transferase dUTP nick end labeling staining. The expression of Bcl-2, Bax, cleaved caspase-3 and -9, and cleaved poly(ADP ribose) polymerase (PARP) in liver tissue was analyzed using W estern blotting. Results: Part 1: Circulating Hsp72 levels increased during sepsis (0, 5.5, 6.5, 10, and 6.5 ng/mL at 0, 3, 6, 9, and 18 h after CLP), positively correlating with survival rates. LPS triggered Hsp72 expression in heat-pretreated rats. Heat pretreatment also increased Hsp72 expression in nonseptic (535%, p < 0.01) and septic (116%, p < 0.01) rat leukocytes. Furthermore, incubating the serum of septic rats with NR8383 cells increased eHsp72 levels in a cultured medium. Cytokine profiling revealed that among the 19 cytokines screened, the levels of cytokine-induced neutrophil chemoattractant 3 (211.3%, p < 0.05), interleukin-10 (147%, p < 0.05), monocyte chemotactic protein 1 (MCP-1; 49.6%, p < 0.05), and tumor necrosis factor alpha (51.8%, p < 0.05) increased. MCP-1 and LPS released Hsp72 from NR8383 cells. Part II: The results revealed that GOT and GPT activities increased by 126% and 121%, respectively, during sepsis and returned to the control level following the administration of recombinant human Hsp72 (rhHsp72). During sepsis, apoptotic cells 8 in liver tissue were augmented (665.7%, p < 0.01); however, the effect was reversed on treatment with rhHsp72. Furthermore, during sepsis, Bcl-2/Bax protein expression in liver tissue was downregulated (&;#8722;26%; p < 0.01), and the downregulation was diminished after rhHsp72 treatment. Moreover, during sepsis, expression of cleaved capase-3, cleaved caspase-9, and PARP in liver tissue was upregulated by 40.9%, 103.3%, and 1106%, respectively, and the upregulation was reversed after treatment with rhHsp72. Conclusion: These results demonstrate that increases in levels of circulating Hsp72 improved the survival rate during sepsis. The increases in circulating Hsp72 may be mediated through MCP-1 and/or LPS. Moreover, during sepsis, eHsp72 restored liver function by ameliorating apoptosis through the mitochondria-initiated caspase pathway . Our findings provide a biochemical basis for the development of rhHsp72 as a therapeutic agent for sepsis management.
Capitoli di libri sul tema "Extracellular HSP27":
Fleshner, Monika, Thomas Maslanik e Lida A. Beninson. "In Vivo Tissue Source and Releasing Signal for Endogenous Extracellular Hsp72". In Heat Shock Proteins and Whole Body Physiology, 193–215. Dordrecht: Springer Netherlands, 2009. http://dx.doi.org/10.1007/978-90-481-3381-9_12.
FLESHNER, MONIKA, CRAIG M. SHARKEY, MOLLY NICKERSON e JOHN D. JOHNSON. "Endogenous Extracellular Hsp72 Release Is an Adaptive Feature of the Acute Stress Response". In Psychoneuroimmunology, 1013–34. Elsevier, 2007. http://dx.doi.org/10.1016/b978-012088576-3/50055-1.
Atti di convegni sul tema "Extracellular HSP27":
Pommerolle, Lenny, Olivier Burgy, Lucile Dondaine, Pierre-Marie Boutanquoi, Guillaume Beltramo, Julie Tanguy, Sabrina Loriod, Carmen Garrido, Philippe Bonniaud e Françoise Goirand. "Role of Extracellular HSP27 in pulmonary fibrosis". In ERS International Congress 2020 abstracts. European Respiratory Society, 2020. http://dx.doi.org/10.1183/13993003.congress-2020.601.
Pommerolle, Lenny, Pierre-Marie Boutanquoi, Florent Thevenet, Lucile Dondaine, Maximilien Spanjaard, Guillaume Beltramo, Carmen Garrido, Philippe Bonniaud e Françoise Goirand. "Role of extracellular HSP27 in idiopathic pulmonary fibrosis (IPF)". In Abstracts from the 17th ERS Lung Science Conference: ‘Mechanisms of Acute Exacerbation of Respiratory Disease’. European Respiratory Society, 2019. http://dx.doi.org/10.1183/23120541.lungscienceconference-2019.pp108.