Articoli di riviste: "Durotaxie"

1

Sunyer, Raimon, e Xavier Trepat. "Durotaxis". Current Biology 30, n. 9 (maggio 2020): R383—R387. http://dx.doi.org/10.1016/j.cub.2020.03.051.

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Huang, Yuxing, Jing Su, Jiayong Liu, Xin Yi, Fang Zhou, Jiaran Zhang, Jiaxiang Wang, Xuan Meng, Lu Si e Congying Wu. "YAP Activation in Promoting Negative Durotaxis and Acral Melanoma Progression". Cells 11, n. 22 (9 novembre 2022): 3543. http://dx.doi.org/10.3390/cells11223543.

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Directed cell migration towards a softer environment is called negative durotaxis. The mechanism and pathological relevance of negative durotaxis in tumor progression still requires in-depth investigation. Here, we report that YAP promotes the negative durotaxis of melanoma. We uncovered that the RhoA-myosin II pathway may underlie the YAP enhanced negative durotaxis of melanoma cells. Acral melanoma is the most common subtype of melanoma in non-Caucasians and tends to develop in a stress-bearing area. We report that acral melanoma patients exhibit YAP amplification and increased YAP activity. We detected a decreasing stiffness gradient from the tumor to the surrounding area in the acral melanoma microenvironment. We further identified that this stiffness gradient could facilitate the negative durotaxis of melanoma cells. Our study advanced the understanding of mechanical force and YAP in acral melanoma and we proposed negative durotaxis as a new mechanism for melanoma dissemination.

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Puleo, Julieann I., Sara S. Parker, Mackenzie R. Roman, Adam W. Watson, Kiarash Rahmani Eliato, Leilei Peng, Kathylynn Saboda et al. "Mechanosensing during directed cell migration requires dynamic actin polymerization at focal adhesions". Journal of Cell Biology 218, n. 12 (8 ottobre 2019): 4215–35. http://dx.doi.org/10.1083/jcb.201902101.

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The mechanical properties of a cell’s microenvironment influence many aspects of cellular behavior, including cell migration. Durotaxis, the migration toward increasing matrix stiffness, has been implicated in processes ranging from development to cancer. During durotaxis, mechanical stimulation by matrix rigidity leads to directed migration. Studies suggest that cells sense mechanical stimuli, or mechanosense, through the acto-myosin cytoskeleton at focal adhesions (FAs); however, FA actin cytoskeletal remodeling and its role in mechanosensing are not fully understood. Here, we show that the Ena/VASP family member, Ena/VASP-like (EVL), polymerizes actin at FAs, which promotes cell-matrix adhesion and mechanosensing. Importantly, we show that EVL regulates mechanically directed motility, and that suppression of EVL expression impedes 3D durotactic invasion. We propose a model in which EVL-mediated actin polymerization at FAs promotes mechanosensing and durotaxis by maturing, and thus reinforcing, FAs. These findings establish dynamic FA actin polymerization as a central aspect of mechanosensing and identify EVL as a crucial regulator of this process.

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Style, R. W., Y. Che, S. J. Park, B. M. Weon, J. H. Je, C. Hyland, G. K. German et al. "Patterning droplets with durotaxis". Proceedings of the National Academy of Sciences 110, n. 31 (24 giugno 2013): 12541–44. http://dx.doi.org/10.1073/pnas.1307122110.

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5

Hartman, Christopher D., Brett C. Isenberg, Samantha G. Chua e Joyce Y. Wong. "Vascular smooth muscle cell durotaxis depends on extracellular matrix composition". Proceedings of the National Academy of Sciences 113, n. 40 (19 settembre 2016): 11190–95. http://dx.doi.org/10.1073/pnas.1611324113.

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Mechanical compliance has been demonstrated to be a key determinant of cell behavior, directing processes such as spreading, migration, and differentiation. Durotaxis, directional migration from softer to more stiff regions of a substrate, has been observed for a variety of cell types. Recent stiffness mapping experiments have shown that local changes in tissue stiffness in disease are often accompanied by an altered ECM composition in vivo. However, the importance of ECM composition in durotaxis has not yet been explored. To address this question, we have developed and characterized a polyacrylamide hydrogel culture platform featuring highly tunable gradients in mechanical stiffness. This feature, together with the ability to control ECM composition, allows us to isolate the effects of mechanical and biological signals on cell migratory behavior. Using this system, we have tracked vascular smooth muscle cell migration in vitro and quantitatively analyzed differences in cell migration as a function of ECM composition. Our results show that vascular smooth muscle cells undergo durotaxis on mechanical gradients coated with fibronectin but not on those coated with laminin. These findings indicate that the composition of the adhesion ligand is a critical determinant of a cell’s migratory response to mechanical gradients.

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Yuehua, YANG, e JIANG Hongyuan. "Research Advances in Cell Durotaxis". 应用数学和力学 42, n. 10 (2021): 999–1007. http://dx.doi.org/10.21656/1000-0887.420265.

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7

Bueno, Jesus, Yuri Bazilevs, Ruben Juanes e Hector Gomez. "Wettability control of droplet durotaxis". Soft Matter 14, n. 8 (2018): 1417–26. http://dx.doi.org/10.1039/c7sm01917c.

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Doering, Charles R., Xiaoming Mao e Leonard M. Sander. "Random walker models for durotaxis". Physical Biology 15, n. 6 (11 settembre 2018): 066009. http://dx.doi.org/10.1088/1478-3975/aadc37.

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Stefanoni, Filippo, Maurizio Ventre, Francesco Mollica e Paolo A. Netti. "A numerical model for durotaxis". Journal of Theoretical Biology 280, n. 1 (luglio 2011): 150–58. http://dx.doi.org/10.1016/j.jtbi.2011.04.001.

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Parida, Lipika, e Venkat Padmanabhan. "Durotaxis in Nematode Caenorhabditis elegans". Biophysical Journal 111, n. 3 (agosto 2016): 666–74. http://dx.doi.org/10.1016/j.bpj.2016.06.030.

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11

DuChez, Brian J., Andrew D. Doyle, Emilios K. Dimitriadis e Kenneth M. Yamada. "Durotaxis by Human Cancer Cells". Biophysical Journal 116, n. 4 (febbraio 2019): 670–83. http://dx.doi.org/10.1016/j.bpj.2019.01.009.

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12

Moriyama, Kousuke, e Satoru Kidoaki. "Cellular Durotaxis Revisited: Initial-Position-Dependent Determination of the Threshold Stiffness Gradient to Induce Durotaxis". Langmuir 35, n. 23 (19 settembre 2018): 7478–86. http://dx.doi.org/10.1021/acs.langmuir.8b02529.

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Feng, Jingchen, Herbert Levine, Xiaoming Mao e Leonard M. Sander. "Cell motility, contact guidance, and durotaxis". Soft Matter 15, n. 24 (2019): 4856–64. http://dx.doi.org/10.1039/c8sm02564a.

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14

Novikova, Elizaveta A., Matthew Raab, Dennis E. Discher e Cornelis Storm. "Cellular Durotaxis from Differentially Persistent Motility". Biophysical Journal 112, n. 3 (febbraio 2017): 436a. http://dx.doi.org/10.1016/j.bpj.2016.11.2327.

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15

Lazopoulos, Konstantinos A., e Dimitrije Stamenović. "Durotaxis as an elastic stability phenomenon". Journal of Biomechanics 41, n. 6 (2008): 1289–94. http://dx.doi.org/10.1016/j.jbiomech.2008.01.008.

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16

Gomez, Hector, e Mirian Velay-Lizancos. "Thin-film model of droplet durotaxis". European Physical Journal Special Topics 229, n. 2-3 (febbraio 2020): 265–73. http://dx.doi.org/10.1140/epjst/e2019-900127-x.

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17

Wei, Jie, Xiaofeng Chen e Bin Chen. "Harnessing structural instability for cell durotaxis". Acta Mechanica Sinica 35, n. 2 (21 marzo 2019): 355–64. http://dx.doi.org/10.1007/s10409-019-00853-2.

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18

Raab, Matthew, Joe Swift, P. C. Dave P. Dingal, Palak Shah, Jae-Won Shin e Dennis E. Discher. "Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain". Journal of Cell Biology 199, n. 4 (5 novembre 2012): 669–83. http://dx.doi.org/10.1083/jcb.201205056.

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On rigid surfaces, the cytoskeleton of migrating cells is polarized, but tissue matrix is normally soft. We show that nonmuscle MIIB (myosin-IIB) is unpolarized in cells on soft matrix in 2D and also within soft 3D collagen, with rearward polarization of MIIB emerging only as cells migrate from soft to stiff matrix. Durotaxis is the tendency of cells to crawl from soft to stiff matrix, and durotaxis of primary mesenchymal stem cells (MSCs) proved more sensitive to MIIB than to the more abundant and persistently unpolarized nonmuscle MIIA (myosin-IIA). However, MIIA has a key upstream role: in cells on soft matrix, MIIA appeared diffuse and mobile, whereas on stiff matrix, MIIA was strongly assembled in oriented stress fibers that MIIB then polarized. The difference was caused in part by elevated phospho-S1943–MIIA in MSCs on soft matrix, with site-specific mutants revealing the importance of phosphomoderated assembly of MIIA. Polarization is thus shown to be a highly regulated compass for mechanosensitive migration.

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19

Liu, Yang, Jiwen Cheng, Hui Yang e Guang-Kui Xu. "Rotational constraint contributes to collective cell durotaxis". Applied Physics Letters 117, n. 21 (23 novembre 2020): 213702. http://dx.doi.org/10.1063/5.0031846.

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20

Harland, Ben, Sam Walcott e Sean X. Sun. "Adhesion dynamics and durotaxis in migrating cells". Physical Biology 8, n. 1 (1 febbraio 2011): 015011. http://dx.doi.org/10.1088/1478-3975/8/1/015011.

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21

Harland, Ben, Sam Walcott e Sean X. Sun. "Adhesion Dynamics and Durotaxis in Migrating Cells". Biophysical Journal 100, n. 3 (febbraio 2011): 303a. http://dx.doi.org/10.1016/j.bpj.2010.12.1855.

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22

Jain, Gaurav, Andrew J. Ford e Padmavathy Rajagopalan. "Opposing Rigidity-Protein Gradients Reverse Fibroblast Durotaxis". ACS Biomaterials Science & Engineering 1, n. 8 (30 luglio 2015): 621–31. http://dx.doi.org/10.1021/acsbiomaterials.5b00229.

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23

McKenzie, Andrew J., Kathryn V. Svec, Tamara F. Williams e Alan K. Howe. "Protein kinase A activity is regulated by actomyosin contractility during cell migration and is required for durotaxis". Molecular Biology of the Cell 31, n. 1 (1 gennaio 2020): 45–58. http://dx.doi.org/10.1091/mbc.e19-03-0131.

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Here, we show that localized PKA activity in migrating cells is regulated by cell–matrix tension, correlates with cellular traction forces, is enhanced by acute mechanical stimulation, and is required for durotaxis. This establishes PKA as an effector of cellular mechanotransduction and as a regulator of mechanically guided cell migration.

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24

Riaz, Maryam, Marie Versaevel e Sylvain Gabriele. "On the Mechanism of Durotaxis in Motile Cells". Biophysical Journal 106, n. 2 (gennaio 2014): 571a. http://dx.doi.org/10.1016/j.bpj.2013.11.3167.

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25

Escribano, Jorge, Raimon Sunyer, María Teresa Sánchez, Xavier Trepat, Pere Roca-Cusachs e José Manuel García-Aznar. "A hybrid computational model for collective cell durotaxis". Biomechanics and Modeling in Mechanobiology 17, n. 4 (2 marzo 2018): 1037–52. http://dx.doi.org/10.1007/s10237-018-1010-2.

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26

Wieland, Annalena, Pamela L. Strissel, Hannah Schorle, Ezgi Bakirci, Dieter Janzen, Matthias W. Beckmann, Markus Eckstein, Paul D. Dalton e Reiner Strick. "Brain and Breast Cancer Cells with PTEN Loss of Function Reveal Enhanced Durotaxis and RHOB Dependent Amoeboid Migration Utilizing 3D Scaffolds and Aligned Microfiber Tracts". Cancers 13, n. 20 (14 ottobre 2021): 5144. http://dx.doi.org/10.3390/cancers13205144.

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Background: Glioblastoma multiforme (GBM) and metastatic triple-negative breast cancer (TNBC) with PTEN mutations often lead to brain dissemination with poor patient outcome, thus new therapeutic targets are needed. To understand signaling, controlling the dynamics and mechanics of brain tumor cell migration, we implemented GBM and TNBC cell lines and designed 3D aligned microfibers and scaffolds mimicking brain structures. Methods: 3D microfibers and scaffolds were printed using melt electrowriting. GBM and TNBC cell lines with opposing PTEN genotypes were analyzed with RHO-ROCK-PTEN inhibitors and PTEN rescue using live-cell imaging. RNA-sequencing and qPCR of tumor cells in 3D with microfibers were performed, while scanning electron microscopy and confocal microscopy addressed cell morphology. Results: In contrast to the PTEN wildtype, GBM and TNBC cells with PTEN loss of function yielded enhanced durotaxis, topotaxis, adhesion, amoeboid migration on 3D microfibers and significant high RHOB expression. Functional studies concerning RHOB-ROCK-PTEN signaling confirmed the essential role for the above cellular processes. Conclusions: This study demonstrates a significant role of the PTEN genotype and RHOB expression for durotaxis, adhesion and migration dependent on 3D. GBM and TNBC cells with PTEN loss of function have an affinity for stiff brain structures promoting metastasis. 3D microfibers represent an important tool to model brain metastasizing tumor cells, where RHO-inhibitors could play an essential role for improved therapy.

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Wieland, Annalena, Pamela L. Strissel, Hannah Schorle, Ezgi Bakirci, Dieter Janzen, Matthias W. Beckmann, Markus Eckstein, Paul D. Dalton e Reiner Strick. "Brain and Breast Cancer Cells with PTEN Loss of Function Reveal Enhanced Durotaxis and RHOB Dependent Amoeboid Migration Utilizing 3D Scaffolds and Aligned Microfiber Tracts". Cancers 13, n. 20 (14 ottobre 2021): 5144. http://dx.doi.org/10.3390/cancers13205144.

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Background: Glioblastoma multiforme (GBM) and metastatic triple-negative breast cancer (TNBC) with PTEN mutations often lead to brain dissemination with poor patient outcome, thus new therapeutic targets are needed. To understand signaling, controlling the dynamics and mechanics of brain tumor cell migration, we implemented GBM and TNBC cell lines and designed 3D aligned microfibers and scaffolds mimicking brain structures. Methods: 3D microfibers and scaffolds were printed using melt electrowriting. GBM and TNBC cell lines with opposing PTEN genotypes were analyzed with RHO-ROCK-PTEN inhibitors and PTEN rescue using live-cell imaging. RNA-sequencing and qPCR of tumor cells in 3D with microfibers were performed, while scanning electron microscopy and confocal microscopy addressed cell morphology. Results: In contrast to the PTEN wildtype, GBM and TNBC cells with PTEN loss of function yielded enhanced durotaxis, topotaxis, adhesion, amoeboid migration on 3D microfibers and significant high RHOB expression. Functional studies concerning RHOB-ROCK-PTEN signaling confirmed the essential role for the above cellular processes. Conclusions: This study demonstrates a significant role of the PTEN genotype and RHOB expression for durotaxis, adhesion and migration dependent on 3D. GBM and TNBC cells with PTEN loss of function have an affinity for stiff brain structures promoting metastasis. 3D microfibers represent an important tool to model brain metastasizing tumor cells, where RHO-inhibitors could play an essential role for improved therapy.

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28

Vicente-Manzanares, Miguel. "Cell Migration: Cooperation between Myosin II Isoforms in Durotaxis". Current Biology 23, n. 1 (gennaio 2013): R28—R29. http://dx.doi.org/10.1016/j.cub.2012.11.024.

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Vicente-Manzanares, Miguel. "Cell Migration: Cooperation between Myosin II Isoforms in Durotaxis". Current Biology 23, n. 5 (marzo 2013): 441. http://dx.doi.org/10.1016/j.cub.2013.02.014.

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Shellard, Adam, e Roberto Mayor. "Collective durotaxis along a self-generated stiffness gradient in vivo". Nature 600, n. 7890 (8 dicembre 2021): 690–94. http://dx.doi.org/10.1038/s41586-021-04210-x.

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31

Sunyer, R., V. Conte, J. Escribano, A. Elosegui-Artola, A. Labernadie, L. Valon, D. Navajas et al. "Collective cell durotaxis emerges from long-range intercellular force transmission". Science 353, n. 6304 (8 settembre 2016): 1157–61. http://dx.doi.org/10.1126/science.aaf7119.

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32

Martinez, Jessica S., Ali M. Lehaf, Joseph B. Schlenoff e Thomas C. S. Keller. "Cell Durotaxis on Polyelectrolyte Multilayers with Photogenerated Gradients of Modulus". Biomacromolecules 14, n. 5 (2 aprile 2013): 1311–20. http://dx.doi.org/10.1021/bm301863a.

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33

Vincent, Ludovic G., Yu Suk Choi, Baldomero Alonso-Latorre, Juan C. del Álamo e Adam J. Engler. "Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength". Biotechnology Journal 8, n. 4 (28 febbraio 2013): 472–84. http://dx.doi.org/10.1002/biot.201200205.

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34

Pamonag, Michael, Abigail Hinson, Elisha J. Burton, Nojan Jafari, Dominic Sales, Sarah Babcock, Rozlan Basha, Xiaofeng Hu e Kristopher E. Kubow. "Individual cells generate their own self-reinforcing contact guidance cues through local matrix fiber remodeling". PLOS ONE 17, n. 3 (25 marzo 2022): e0265403. http://dx.doi.org/10.1371/journal.pone.0265403.

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Directed cell migration arises from cells following a microenvironmental gradient (e.g. of a chemokine) or polarizing feature (e.g. a linear structure). However cells not only follow, but in many cases, also generate directionality cues by modifying their microenvironment. This bi-directional relationship is seen in the alignment of extracellular matrix (ECM) fibers ahead of invading cell masses. The forces generated by many migrating cells cause fiber alignment, which in turn promotes further migration in the direction of fiber alignment via contact guidance and durotaxis. While this positive-feedback relationship has been widely described for cells invading en masse, single cells are also able to align ECM fibers, as well as respond to contact guidance and durotaxis cues, and should therefore exhibit the same relationship. In this study, we directly tested this hypothesis by studying the migration persistence of individual HT-1080 fibrosarcoma cells migrating in photocrosslinked collagen matrices with limited remodeling potential. Our results demonstrate that this positive-feedback relationship is indeed a fundamental aspect of cell migration in fibrillar environments. We observed that the cells’ inability to align and condense fibers resulted in a decrease in persistence relative to cells in native collagen matrices and even relative to isotropic (glass) substrates. Further experiments involving 2D collagen and electrospun polymer scaffolds suggest that substrates composed of rigid, randomly oriented fibers reduce cells’ ability to follow another directionality cue by forcing them to meander to follow the available adhesive area (i.e. fibers). Finally, our results demonstrate that the bi-directional relationship between cell remodeling and migration is not a “dimensionality” effect, but a fundamental effect of fibrous substrate structure.

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Aubry, D., M. Gupta, B. Ladoux e R. Allena. "Mechanical link between durotaxis, cell polarity and anisotropy during cell migration". Physical Biology 12, n. 2 (17 aprile 2015): 026008. http://dx.doi.org/10.1088/1478-3975/12/2/026008.

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Isenberg, Brett C., Paul A. DiMilla, Matthew Walker, Sooyoung Kim e Joyce Y. Wong. "Vascular Smooth Muscle Cell Durotaxis Depends on Substrate Stiffness Gradient Strength". Biophysical Journal 97, n. 5 (settembre 2009): 1313–22. http://dx.doi.org/10.1016/j.bpj.2009.06.021.

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Kuntanawat, P., C. Wilkinson e M. Riehle. "Observation of durotaxis on a well-defined continuous gradient of stiffness". Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 146, n. 4 (aprile 2007): S192. http://dx.doi.org/10.1016/j.cbpa.2007.01.421.

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Wormer, Duncan B., Kevin A. Davis, James H. Henderson e Christopher E. Turner. "The Focal Adhesion-Localized CdGAP Regulates Matrix Rigidity Sensing and Durotaxis". PLoS ONE 9, n. 3 (14 marzo 2014): e91815. http://dx.doi.org/10.1371/journal.pone.0091815.

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Ebata, Hiroyuki, Kousuke Moriyama, Thasaneeya Kuboki e Satoru Kidoaki. "General cellular durotaxis induced with cell-scale heterogeneity of matrix-elasticity". Biomaterials 230 (febbraio 2020): 119647. http://dx.doi.org/10.1016/j.biomaterials.2019.119647.

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Shellard, Adam, e Roberto Mayor. "Publisher Correction: Collective durotaxis along a self-generated stiffness gradient in vivo". Nature 601, n. 7894 (12 gennaio 2022): E33. http://dx.doi.org/10.1038/s41586-021-04367-5.

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Budde, Ilka, David Ing, Albrecht Schwab e Zoltan Denes Petho. "Mechanosensitive ion channels are essential for the durotaxis of pancreatic stellate cells". Biophysical Journal 121, n. 3 (febbraio 2022): 314a. http://dx.doi.org/10.1016/j.bpj.2021.11.1181.

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42

Alert, Ricard, e Jaume Casademunt. "Role of Substrate Stiffness in Tissue Spreading: Wetting Transition and Tissue Durotaxis". Langmuir 35, n. 23 (3 ottobre 2018): 7571–77. http://dx.doi.org/10.1021/acs.langmuir.8b02037.

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43

Allena, R., M. Scianna e L. Preziosi. "A Cellular Potts Model of single cell migration in presence of durotaxis". Mathematical Biosciences 275 (maggio 2016): 57–70. http://dx.doi.org/10.1016/j.mbs.2016.02.011.

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Malik, Adam A., e Philip Gerlee. "Mathematical modelling of cell migration: stiffness dependent jump rates result in durotaxis". Journal of Mathematical Biology 78, n. 7 (10 aprile 2019): 2289–315. http://dx.doi.org/10.1007/s00285-019-01344-5.

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Whang, Minji, e Jungwook Kim. "Synthetic hydrogels with stiffness gradients for durotaxis study and tissue engineering scaffolds". Tissue Engineering and Regenerative Medicine 13, n. 2 (aprile 2016): 126–39. http://dx.doi.org/10.1007/s13770-016-0026-x.

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46

Marzban, Bahador, Xin Yi e Hongyan Yuan. "A minimal mechanics model for mechanosensing of substrate rigidity gradient in durotaxis". Biomechanics and Modeling in Mechanobiology 17, n. 3 (22 gennaio 2018): 915–22. http://dx.doi.org/10.1007/s10237-018-1001-3.

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Zhang, Zhiwen, Phoebus Rosakis, Thomas Y. Hou e Guruswami Ravichandran. "A minimal mechanosensing model predicts keratocyte evolution on flexible substrates". Journal of The Royal Society Interface 17, n. 166 (maggio 2020): 20200175. http://dx.doi.org/10.1098/rsif.2020.0175.

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A mathematical model is proposed for shape evolution and locomotion of fish epidermal keratocytes on elastic substrates. The model is based on mechanosensing concepts: cells apply contractile forces onto the elastic substrate, while cell shape evolution depends locally on the substrate stress generated by themselves or external mechanical stimuli acting on the substrate. We use the level set method to study the behaviour of the model numerically, and predict a number of distinct phenomena observed in experiments, such as (i) symmetry breaking from the stationary centrosymmetric to the well-known steadily propagating crescent shape, (ii) asymmetric bipedal oscillations and travelling waves in the lamellipodium leading edge, (iii) response to remote mechanical stress externally applied to the substrate (tensotaxis) and (iv) changing direction of motion towards an interface with a rigid substrate (durotaxis).

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Lachowski, Dariusz, Ernesto Cortes, Benjamin Robinson, Alistair Rice, Krista Rombouts e Armando E. Del Río Hernández. "FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis". FASEB Journal 32, n. 2 (3 gennaio 2018): 1099–107. http://dx.doi.org/10.1096/fj.201700721r.

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49

Walker, Matthew L., David House, Margrit Betke e Joyce Y. Wong. "Using Automated Cell Tracking Software to Quantifying Durokinesis and Durotaxis in Real Time". Biophysical Journal 96, n. 3 (febbraio 2009): 633a. http://dx.doi.org/10.1016/j.bpj.2008.12.3347.

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50

Sunyer, Raimon, Albert J. Jin, Ralph Nossal e Dan L. Sackett. "Fabrication of Hydrogels with Gradient of Compliance: Application to Cell Mechanotaxis and Durotaxis". Biophysical Journal 102, n. 3 (gennaio 2012): 565a. http://dx.doi.org/10.1016/j.bpj.2011.11.3077.

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Articoli di riviste sul tema "Durotaxie"

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