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Mayer, Richard E., e Richard B. Anderson. "Animations need narrations: An experimental test of a dual-coding hypothesis." Journal of Educational Psychology 83, n. 4 (1991): 484–90. http://dx.doi.org/10.1037/0022-0663.83.4.484.
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Visvanathan, Deepa. "AGRAMMATIC PATIENT’S DUAL CODING PROCESS IN SENTENCE COMPREHENSION". International Journal of Education, Psychology and Counseling 5, n. 37 (3 dicembre 2020): 159–72. http://dx.doi.org/10.35631/ijepc.5370013.
Testo completoAbstract (sommario):
This paper reports on a study on the dual coding process involved in an agrammatic patient when comprehending sentences using a sentence to picture matching test. The test was undertaken at The National Stroke Association of Malaysia (NASAM), Petaling Jaya, Malaysia. The current study employs the theory of Paivio’s (1991) Dual Coding Theory (DCT) as an explanation for the agrammatic patient’s ability to comprehend active and passive sentences and adopts an influential hypothesis by Grodzinsky’s (1990) Trace Deletion Hypothesis (TDH) concerning agrammatism that characterises agrammatic patients as a good comprehender of Subject Verb Object (SVO) sentence structure, the active sentence but as bad comprehenders of Object Verb Subject (OVS) sentence structure, the passive sentences. A comprehension test, the Sentence to Picture Matching Test designed by Christensen (2001) has been adopted in this study to examine the suitability of dual coding theory as an explanation for the agrammatic patient’s comprehension ability. The performance of the patient’s comprehension pattern in this study supports the account of TDH and in general, the findings of this study suggest that sentence to picture matching test could be used to investigate the dual coding process of the agrammatic patient.
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Bukinich, Anna Aleksandrovna, e Petr Dmitriyevich Shabanov. "The human brain is working in the system of dual coding: a hypothesis". Reviews on Clinical Pharmacology and Drug Therapy 11, n. 2 (15 giugno 2013): 52–56. http://dx.doi.org/10.17816/rcf11252-56.
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How the human brain is working is up to now unclear. Using singular neuron as an object, and pharmacological agents as a tool the neuron activity in general in the mammalian CNS has been described. The basis of all investigations was the study of dimmer (heteromer) structures associated with G-coupled receptor proteins on the surfaces of neuron membranes isolated from the own usual circle. We can organize the recombinant movement by means of physiological concentrations of pharmacological reagents if these processes were lasting in the network neurons native brain. That is, the ideal conditions for the processes generation in the neural impulse were reconstructed.
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Cuevas, Joshua, e Bryan L. Dawson. "A test of two alternative cognitive processing models: Learning styles and dual coding". Theory and Research in Education 16, n. 1 (19 settembre 2017): 40–64. http://dx.doi.org/10.1177/1477878517731450.
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This study tested two cognitive models, learning styles and dual coding, which make contradictory predictions about how learners process and retain visual and auditory information. Learning styles-based instructional practices are common in educational environments despite a questionable research base, while the use of dual coding is less ubiquitous, and thus measured examination of the two methods has implications for practical application. The study involved 204 university students who were surveyed on their preferred learning style and then presented with information that they were prompted to process via either imagery or linguistic means. The results showed there was no significant interaction effect between learning style and condition, suggesting the most basic prediction of the learning styles hypothesis should be rejected. In a regression analysis, none of the four learning styles (visual, auditory, read/write, or kinesthetic) predicted students’ retention of the material. However, there was a highly significant main effect of condition with those in the visual condition retaining twice as much information as those in the auditory condition regardless of learning style, a result that strongly supports dual coding theory. Implications of the findings would suggest that learning styles instruction is an ineffective method for teachers to employ, and that, instead, incorporating principles of dual coding would have a much greater benefit to student learning.
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Tang, Yidong, Shucai Huang e Aijun Xue. "Sparse Representation Based Binary Hypothesis Model for Hyperspectral Image Classification". Mathematical Problems in Engineering 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/3460281.
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The sparse representation based classifier (SRC) and its kernel version (KSRC) have been employed for hyperspectral image (HSI) classification. However, the state-of-the-art SRC often aims at extended surface objects with linear mixture in smooth scene and assumes that the number of classes is given. Considering the small target with complex background, a sparse representation based binary hypothesis (SRBBH) model is established in this paper. In this model, a query pixel is represented in two ways, which are, respectively, by background dictionary and by union dictionary. The background dictionary is composed of samples selected from the local dual concentric window centered at the query pixel. Thus, for each pixel the classification issue becomes an adaptive multiclass classification problem, where only the number of desired classes is required. Furthermore, the kernel method is employed to improve the interclass separability. In kernel space, the coding vector is obtained by using kernel-based orthogonal matching pursuit (KOMP) algorithm. Then the query pixel can be labeled by the characteristics of the coding vectors. Instead of directly using the reconstruction residuals, the different impacts the background dictionary and union dictionary have on reconstruction are used for validation and classification. It enhances the discrimination and hence improves the performance.
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Luo, Li. "A Study on the Application of Computer-Aided Dual-Coding Theory in English Vocabulary Teaching". Scientific Programming 2022 (16 marzo 2022): 1–10. http://dx.doi.org/10.1155/2022/5951844.
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Learning English needs a huge amount of vocabulary recalls as well as multiple grammatical structures and practices. With the development and improvement of the humanization and quality of English teaching, the multidimensional teaching of English has formed a powerful learning model and teaching method. The teaching of dual-coding theory assisted by computer teaching software mainly focuses on the dual activation representation of language combined with nonverbal graphic recognition to complete the recognition of information. According to the dual-coding hypothesis, in Gilford’s intelligence theory, the capacity of spatial and information recognition and reading is highly significant. With the large amount of visual recognition and information acquisition, images involve spatial domain information reading, which is a learning method based on the principle of information feature recognition. Based on the principle of dual-coding theory, it is a very effective way to present information and recall specific information in the form of vision and language. In this study, the application research for the purpose of English vocabulary teaching is adopted that has strong innovative and practical characteristics. According to the steps and contents of English vocabulary learning, the study is carried out step by step from the context in detail, so it continuously improves the learning quality and efficiency of English vocabulary teaching. Vocabulary teaching can help the students better improve their cognitive level of vocabulary and meet the vocabulary test requirements of the new institution entrance examination. Further, how to improve the effect of senior high school English vocabulary teaching is a major topic in the field of senior high school English teaching. In order to sort out this issue, I proposed a computer-aided dual-coding theory to help quickly understand vocabulary usage in order to increase learning efficiency. The Paivio–Desrochers model is used in this study. In addition, this study also attempts to explore the application of dual-coding theory in senior high school English vocabulary teaching.
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David, Prabu. "Role of Imagery in Recall of Deviant News". Journalism & Mass Communication Quarterly 73, n. 4 (dicembre 1996): 804–20. http://dx.doi.org/10.1177/107769909607300404.
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The purpose of this paper is to examine why a deviant news story such as “Man bites dog” is more memorable than “Dog bites man.” Distinctiveness and imagery present two competing theoretical positions to explain the advantage that deviant news events have over nondeviant events. While the distinctiveness hypothesis is based on schema incongruence, the imagery hypothesis is based on Paivio's dual coding theory. Findings from two experiments support the imagery hypothesis, which suggests that imagery-evoking potential of deviant news is a better predictor of recall than schema incongruity. The advantage in recall for deviant news almost disappeared for high deviance/low imagery news events. Further, path analysis from both experiments indicates that there is no direct path between deviance and recall, but only an indirect path through imagery. In sum, this paper highlights the importance of imagery in news language and its potential impact on memory and learning.
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Kepple, Daniel R., Hamza Giaffar, Dmitry Rinberg e Alexei A. Koulakov. "Deconstructing Odorant Identity via Primacy in Dual Networks". Neural Computation 31, n. 4 (aprile 2019): 710–37. http://dx.doi.org/10.1162/neco_a_01175.
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In the olfactory system, odor percepts retain their identity despite substantial variations in concentration, timing, and background. We study a novel strategy for encoding intensity-invariant stimulus identity that is based on representing relative rather than absolute values of stimulus features. For example, in what is known as the primacy coding model, odorant identities are represented by the conditions that some odorant receptors are activated more strongly than others. Because, in this scheme, odorant identity depends only on the relative amplitudes of olfactory receptor responses, identity is invariant to changes in both intensity and monotonic nonlinear transformations of its neuronal responses. Here we show that sparse vectors representing odorant mixtures can be recovered in a compressed sensing framework via elastic net loss minimization. In the primacy model, this minimization is performed under the constraint that some receptors respond to a given odorant more strongly than others. Using duality transformation, we show that this constrained optimization problem can be solved by a neural network whose Lyapunov function represents the dual Lagrangian and whose neural responses represent the Lagrange coefficients of primacy and other constraints. The connectivity in such a dual network resembles known features of connectivity in olfactory circuits. We thus propose that networks in the piriform cortex implement dual computations to compute odorant identity with the sparse activities of individual neurons representing Lagrange coefficients. More generally, we propose that sparse neuronal firing rates may represent Lagrange multipliers, which we call the dual brain hypothesis. We show such a formulation is well suited to solve problems with multiple interacting relative constraints.
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van Hell, Janet G., e Annette M. B. de Groot. "Disentangling Context Availability and Concreteness in Lexical Decision and Word Translation". Quarterly Journal of Experimental Psychology Section A 51, n. 1 (febbraio 1998): 41–63. http://dx.doi.org/10.1080/713755752.
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This study examines contrasting predictions of the dual coding theory and the context availability hypothesis regarding concreteness effects in monolingual and bilingual lexical processing. In three experiments, concreteness was controlled for or confounded with rated context availability. In the first experiment, bilingual subjects performed lexical decision in their native language (Dutch, L1). In the second experiment, lexical decision performance of bilinguals in their second language (English, L2) was examined. In the third experiment, bilinguals translated words “forwards” (from L1 to L2) or “backwards” (from L2 to L1). Both monolingual and bilingual tasks showed a concreteness effect when concreteness was confounded with context availability. However, concreteness effects disappeared when abstract and concrete words were matched on context availability, and even occasionally reversed. Implications of these results for theories that account for concreteness effects, particulary in bilingual processing, are discussed.
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Walma van der Molen, J. "The impact of television, print, and audio on children's recall of the news. A study of three alternative explanations for the dual-coding hypothesis". Human Communication Research 26, n. 1 (1 gennaio 2000): 3–26. http://dx.doi.org/10.1093/hcr/26.1.3.
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Deckert, Mikołaj. "Translatorial dual-processing–evidence from interlingual trainee subtitling". Babel. Revue internationale de la traduction / International Journal of Translation 62, n. 3 (21 novembre 2016): 495–515. http://dx.doi.org/10.1075/babel.62.3.07dec.
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Drawing on cognitive linguistics and psychology, this paper attempts to model the subtitler’s decision-making as involving two types of operations. They are referred to as System 1 and System 2, the former being fast, automatic and requiring little effort, and the latter being slower, controlled and effortful. To test the dual-processing hypothesis, I analyse trainee subtitlers’ renditions with a focus on the construction “you + to like + me” which exemplifies a cross-language asymmetry and a potential (disguised) translation challenge. Remarkably, the English construction is employed equally-conventionally to represent the concept of being favourably disposed to somebody in a non-physical/sexual manner, on the one hand, and being attracted to somebody, on the other. In Polish, however, the “prototypes” will typically be represented as distinct expressions. The present findings suggest that because differentiating between the prototypes and coding them linguistically is not challenging to the participants, it is the automation of their judgment that leads them to settle for flawed target variants (Stage 1). Additional evidence is obtained (Stage 2) as participants are induced to go from System 1 to System 2 thinking–a cross-stage comparison indicates that the fast-to-slow switch reorients the trainees’ subtitling choices and ultimately improves translation quality.
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Popović Stijačić, Milica, e Dušica Filipović Đurđević. "Perceptual richness of words and its role in free and cued recall". Primenjena psihologija 15, n. 3 (17 novembre 2022): 355–81. http://dx.doi.org/10.19090/pp.v15i3.2400.
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This research aimed to clarify the role of the perceptual richness of words (PR) in the recall tasks. PR was operationalized as the number of sensory modalities through which an object can be perceived. Previously, we found that concepts experienced with many modalities (dog) were recalled more accurately in cued recall than those perceived with few modalities (rainbow) and abstract words. This finding fitted the Perceptual symbol system theory (PSST) and the Dual coding theory (DCT) predictions. We tested the PR effect in both cued (experiment 1- E1) and free recall tasks (experiment 2 – E2) in the present study. With careful stimuli manipulation of context availability and emotional valence and statistical control of arousal and relatedness, made to exclude their influence on recall, we tested alternative explanations of the concreteness effect offered by the relational-distinctiveness hypothesis. The additional perceptual codes improved recall accuracy in the cued recall task (E1), which was in line with the PSST and the DCT. This conclusion is straightforward: two critical groups of concrete words were matched for concreteness and visual perceptual strength. Thus, more accurate recall of concepts experienced with many modalities can be attributed to richer perceptual experience. However, the relational information was essential for recall accuracy in the free recall task (E2), as hypothesized by the relational-distinctiveness hypothesis.
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Strum, David P., Jerrold H. May, Allan R. Sampson, Luis G. Vargas e William E. Spangler. "Estimating Times of Surgeries with Two Component Procedures". Anesthesiology 98, n. 1 (1 gennaio 2003): 232–40. http://dx.doi.org/10.1097/00000542-200301000-00035.
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Background Variability inherent in the duration of surgical procedures complicates surgical scheduling. Modeling the duration and variability of surgeries might improve time estimates. Accurate time estimates are important operationally to improve utilization, reduce costs, and identify surgeries that might be considered outliers. Surgeries with multiple procedures are difficult to model because they are difficult to segment into homogenous groups and because they are performed less frequently than single-procedure surgeries. Methods The authors studied, retrospectively, 10,740 surgeries each with exactly two CPTs and 46,322 surgical cases with only one CPT from a large teaching hospital to determine if the distribution of dual-procedure surgery times fit more closely a lognormal or a normal model. The authors tested model goodness of fit to their data using Shapiro-Wilk tests, studied factors affecting the variability of time estimates, and examined the impact of coding permutations (ordered combinations) on modeling. Results The Shapiro-Wilk tests indicated that the lognormal model is statistically superior to the normal model for modeling dual-procedure surgeries. Permutations of component codes did not appear to differ significantly with respect to total procedure time and surgical time. To improve individual models for infrequent dual-procedure surgeries, permutations may be reduced and estimates may be based on the longest component procedure and type of anesthesia. Conclusions The authors recommend use of the lognormal model for estimating surgical times for surgeries with two component procedures. Their results help legitimize the use of log transforms to normalize surgical procedure times prior to hypothesis testing using linear statistical models. Multiple-procedure surgeries may be modeled using the longest (statistically most important) component procedure and type of anesthesia.
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Druey, Michel D., e Ronald Hübner. "Effects of stimulus features and instruction on response coding, selection, and inhibition: Evidence from repetition effects under task switching". Quarterly Journal of Experimental Psychology 61, n. 10 (ottobre 2008): 1573–600. http://dx.doi.org/10.1080/17470210701643397.
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The coding of stimuli and responses is crucial for human behaviour. Here, we focused primarily on the response codes (or response categories). As a method, we applied a combined dual-task and task-switch paradigm with a fixed task-to-hand mapping. Usually, negative effects (i.e., costs) are observed for response category repetitions under task switching. However, in several previous studies it has been proposed that such repetition effects do not occur, if the stimulus categories (e.g., “odd” if digits have to be classified according to their parity feature) are unequivocally mapped to specific responses. Our aim was to test this hypothesis. In the present experiments, we were able to distinguish between three different types of possible response codes. The results show that the participants generally code their responses according to abstract response features (left/right, or index/middle finger). Moreover, the spatial codes were preferred over the finger-type codes even if the instructions stressed the latter. This preference, though, seemed to result from a stimulus–response feature overlap, so that the spatial response categories were primed by the respective stimulus features. If there was no such overlap, the instructions determined which type of response code was involved in response selection and inhibition.
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Masuda, Naoki, e Kazuyuki Aihara. "Dual coding hypotheses for neural information representation". Mathematical Biosciences 207, n. 2 (giugno 2007): 312–21. http://dx.doi.org/10.1016/j.mbs.2006.09.009.
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Zhang, Tao, Can Chen, Shushu Han, Lan Chen, Hao Ding, Yueyue Lin, Genxi Zhang, Kaizhou Xie, Jinyu Wang e Guojun Dai. "Integrated Analysis Reveals a lncRNA–miRNA–mRNA Network Associated with Pigeon Skeletal Muscle Development". Genes 12, n. 11 (11 novembre 2021): 1787. http://dx.doi.org/10.3390/genes12111787.
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Growing evidence has demonstrated the emerging role of long non-coding RNA as competitive endogenous RNA (ceRNA) in regulating skeletal muscle development. However, the mechanism of ceRNA regulated by lncRNA in pigeon skeletal muscle development remains unclear. To reveal the function and regulatory mechanisms of lncRNA, we first analyzed the expression profiles of lncRNA, microRNA (miRNA), and mRNA during the development of pigeon skeletal muscle using high-throughput sequencing. We then constructed a lncRNA–miRNA–mRNA ceRNA network based on differentially expressed (DE) lncRNAs, miRNAs, and mRNAs according to the ceRNA hypothesis. Functional enrichment and short time-series expression miner (STEM) analysis were performed to explore the function of the ceRNA network. Hub lncRNA–miRNA–mRNA interactions were identified by connectivity degree and validated using dual-luciferase activity assay. The results showed that a total of 1625 DE lncRNAs, 11,311 DE mRNAs, and 573 DE miRNAs were identified. A ceRNA network containing 9120 lncRNA–miRNA–mRNA interactions was constructed. STEM analysis indicated that the function of the lncRNA-associated ceRNA network might be developmental specific. Functional enrichment analysis identified potential pathways regulating pigeon skeletal muscle development, such as cell cycle and MAPK signaling. Based on the connectivity degree, lncRNAs TCONS_00066712, TCONS_00026594, TCONS_00001557, TCONS_00001553, and TCONS_00003307 were identified as hub genes in the ceRNA network. lncRNA TCONS_00026594 might regulate the FSHD region gene 1 (FRG1)/ SRC proto-oncogene, non-receptor tyrosine kinase (SRC) by sponge adsorption of cli-miR-1a-3p to affect the development of pigeon skeletal muscle. Our findings provide a data basis for in-depth elucidation of the lncRNA-associated ceRNA mechanism underlying pigeon skeletal muscle development.
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Liao, Ying. "Analysis of Rehabilitation Occupational Therapy Techniques Based on Instrumental Music Chinese Tonal Language Spectrogram Analysis". Occupational Therapy International 2022 (3 ottobre 2022): 1–12. http://dx.doi.org/10.1155/2022/1064441.
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This paper provides an in-depth analysis of timbre-speech spectrograms in instrumental music, designs a model analysis of rehabilitation occupational therapy techniques based on the analysis of timbre-speech spectrograms in instrumental music, and tests the models for comparison. Starting from the mechanism of human articulation, this paper models the process of human expression as a time-varying linear system consisting of excitation, vocal tract, and radiation models. The system’s overall architecture is designed according to the characteristics of Chinese speech and everyday speech rehabilitation theory (HSL theory). The dual judgment of temporal threshold and short-time average energy realized the phonetic length training. Tone and clear tone training were achieved by linear predictive coding technique (LPC) and autocorrelation function. Using the DTW technique, isolated word speech recognition was achieved by extracting Mel-scale Frequency Cepstral Coefficients (MFCC) parameters of speech signals. The system designs corresponding training scenes for each training module according to the extracted speech parameters, combines the multimedia speech spectrogram motion situation with the speech parameters, and finally presents the training content as a speech spectrogram, and evaluates the training results through human-machine interaction to stimulate the interest of rehabilitation therapy and realize the speech rehabilitation training of patients. After analyzing the pre- and post-test data, it was found that the p -values of all three groups were <0.05, which was judged to be significantly different. Also, all subjects changed their behavioral data during the treatment. Therefore, it was concluded that the music therapy technique could improve the patients’ active gaze communication ability, verbal command ability, and active question-answering ability after summarizing the data, i.e., the hypothesis of this experiment is valid. Therefore, it is believed that the technique of timbre-speech spectrogram analysis in instrumental music can achieve the effect of rehabilitation therapy to a certain extent.
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West, W. Caroline, e Phillip J. Holcomb. "Imaginal, Semantic, and Surface-Level Processing of Concrete and Abstract Words: An Electrophysiological Investigation". Journal of Cognitive Neuroscience 12, n. 6 (novembre 2000): 1024–37. http://dx.doi.org/10.1162/08989290051137558.
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Words representing concrete concepts are processed more quickly and efficiently than words representing abstract concepts. Concreteness effects have also been observed in studies using event-related brain potentials (ERPs). The aim of this study was to examine concrete and abstract words using both reaction time (RT) and ERP measurements to determine (1) at what point in the stream of cognitive processing concreteness effects emerge and (2) how different types of cognitive operations influence these concreteness effects. Three groups of subjects performed a sentence verification task in which the final word of each sentence was concrete or abstract. For each group the truthfulness judgment required either (1) image generation, (2) a semantic decision, or (3) evaluation of surface characteristics. Concrete and abstract words produced similar RTs and ERPs in the surface task, suggesting that postlexical semantic processing is necessary to elicit concreteness effects. In both the semantic and imagery tasks, RTs were shorter for concrete than for abstract words. This difference was greatest in the imagery task. Also, in both of these tasks concrete words elicited more negative ERPs than abstract words between 300 and 550 msec (N400). This effect was widespread across the scalp and may reflect activation in a linguistic semantic system common to both concrete and abstract words. ERPs were also more negative for concrete than abstract words between 550 and 800 msec. This effect was more frontally distributed and was most evident in the imagery task. We propose that this later anterior effect represents a distinct ERP component (N700) that is sensitive to the use of mental imagery. The N700 may reflect the access of specific characteristics of the imaged item or activation in a working memory system specific to mental imagery. These results also support the extended dual-coding hypothesis that superior associative connections and the use of mental imagery both contribute to processing advantages for concrete words over abstract words.
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Riancho, José A., María T. Zarrabeitia, Carmen Valero, Carolina Sañudo, Verónica Mijares e Jesús González-Macías. "A gene-to-gene interaction between aromatase and estrogen receptors influences bone mineral density". European Journal of Endocrinology 155, n. 1 (luglio 2006): 53–59. http://dx.doi.org/10.1530/eje.1.02189.
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Objective: The aromatization of androgenic precursors is the main source of estrogens in postmenopausal women. We tested the hypothesis that allelic variants of the genes coding for aromatase and estrogen receptors (ER) could interact to determine the estrogenic signals on the bone tissue and, consequently, bone mineral density (BMD). Design: Cross-sectional study including 331 postmenopausal women. Methods: BMD was measured by dual energy x-ray absorptiometry. A CG polymorphism of the aromatase gene as well as three polymorphisms of ERα (a TA repeat in the promoter region, a C T single nucleotide polymorphism (SNP) in intron 1 and an AG SNP in exon 8) and a CA repeat polymorphism of ERβ were studied. Results: Age, body weight and the aromatase genotype were associated with BMD. Allelic variants of ERβ and the exon 8 of ERα did not show a significant association with BMD. The polymorphisms located on the promoter and intron 1 of ERα interacted strongly with aromatase. Thus, in women TT homozygous for the ERα gene, there was a marked influence of aromatase genotypes on BMD: spine BMD was 0.724±0.027 g/cm2 in women with CC aromatase alleles and 0.926±0.032 g/cm2 in those with GG alleles (P<0.001). Hip BMD in women with CC and GG aromatase genotypes was 0.722±0.020 and 0.842±0.026 g/cm2 respectively (P=0.002). On the contrary, there were no aromatase-related differences in BMD in women with CT/CC alleles of ERα. Similarly, aromatase-related differences in BMD were found in women with short alleles at the promoter region of ERα, but not in those with long alleles. Both ERα polymorphisms were in strong linkage disequilibrium (P<0.001). Conclusion: These results suggest that the interaction between polymorphisms of genes involved in estrogen synthesis and estrogen signaling exerts an important influence on BMD in postmenopausal women, thus helping to explain, in part, its heritable component. Nevertheless, further studies are warranted to confirm this gene-to-gene interaction in other populations.
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Huang, Tseng-Lung, e Yi-Mu Chen. "Young audiences’ emotional experience on smartphone film: an application of dual-coding theory". Young Consumers 15, n. 2 (10 giugno 2014): 193–208. http://dx.doi.org/10.1108/yc-07-2013-00384.
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Purpose – This study aims to determine whether smartphones create the best communication fit with a young audience. Design/methodology/approach – To validate the hypotheses, a task-based laboratory study was conducted. And smartphone film and television (TV) film were provided in the laboratory. Young respondents were recruited in the classroom and brief introduction and film were broadcasted. After watching the film, levels of respondent’s emotional experience was measured via questionnaire. Findings – The results indicate that when the text of the film matches the young audience’s schema, the young audience uses, mainly, imagery coding to interpret the text and achieve an emotional experience. Conversely, when the text and schema do not match, the young audience uses both proposition coding and imagery coding. Practical implications – Based on the results found in this study, companies should use different texts to match the different schema of young audiences to ensure that audiences can process coding and enjoy emotional experiences when using smartphone. Originality/value – Dual-coding theory is applied to determine which coding system the audience use to interpret the new-media text, such as smartphone films.
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Matei, Sorin Adam, Lance Madsen e Robert Bruno. "Information Acquisition and Recall in Location-Aware and Search Engine Retrieval Systems". International Journal of Information Technology and Web Engineering 5, n. 2 (aprile 2010): 32–52. http://dx.doi.org/10.4018/jitwe.2010040103.
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This paper examines the potential cognitive impact of location aware information systems compared to that of search engines using a dual coding and conjoint retention theoretical framework. Supported by virtual reality or mobile devices, location aware systems deliver information that is relevant for a specific location. Research questions and hypotheses formulated under the assumption that location aware systems are better prepared to contextualize and make information memorable are explored using a planned comparison repeated measures 3 (2 treatment; 1 control) x 3 (pre-test, post-test, one week post-test) design. The results indicate that information acquisition in location-aware systems is just as powerful as that facilitated by search engines and that information recall (after 1 week) of facts is superior when using location-aware systems. The findings reinforce and extend dual coding theory suggesting that spatial and three-dimensional indexing can be one of the channels used in indexing and recalling information. The results also indicate that location-aware applications are a promising technology for distributing information in general and for learning in particular.
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Myers, Scott N., Rakesh K. Goyal, Jennifer D. Roy e Robert E. Ferrell. "Identification and Effects of Novel Promoter Region Haplotypes in the Human Equilibrative Nucleoside Transporter, hENT1." Blood 104, n. 11 (16 novembre 2004): 2083. http://dx.doi.org/10.1182/blood.v104.11.2083.2083.
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Abstract Front-line induction chemotherapy regimens containing cytosine arabinoside (Ara-C) and anthracyclines result in 80% complete remission rate in childhood acute myeloid leukemia (AML) but their cure rate is about 35 – 50%, one of the lowest of all childhood cancers. Understanding the factors that contribute to emergence of chemoresistant leukemic cells is crucial to improving treatment outcome in children with AML. We are interested in studying the role of variation in Ara-C transport and biotransformation pathway genes in the efficacy and toxicity of treatment of childhood AML. To permeate the cell membrane, Ara-C is mainly dependent on human equilibrative nucleoside transporter 1 (hENT1; SLC29A1; gene localized to 6p21.1). Several studies have suggested an important role for altered levels of hENT1 in the chemosensitivity of AML blasts to Ara-C (Galmarini et al. Leukemia2001; 15(6):87; Gati et al. Leuk Lymphoma1998; 32(1–2):45). Osato and colleagues identified two single nucleotide polymorphisms (SNPs) in the hENT1 coding sequence that led to missense changes, but their in vitro analysis did not detect differences in the activity of variant alleles in a yeast transfection system (Osato et al. Pharmacogenetics2003;13(5):297). To identify variation in hENT1 that might influence its expression, we sequenced 1.6Kb of the proximal 5′-flanking sequence of the gene in 42 unrelated individuals and identified three SNPs at positions C-1345G, G-1050A, and G-706C. TRANSFAC analysis (www.genomatix.de) predicted that two of these (C-1345G & G-706C) would alter consensus transcription factor binding site sequences. We cloned four naturally occurring haplotypes (CGG, CAG, CGC, and GAG) using the TOPO-TA cloning kit, then transfected Cos-1 cells using the Lipofectamine 2000 protocol. Gene expression was assayed using the Promega Dual-Luciferase Reporter Assay System and read on a Molecular Devices HT Analyzer. Luciferase activity was measured at 24 and 48 hours after transfection for six replicates of every condition during three separate transfections. To correct for differences in transfection efficiencies, experimental (Photinus pyralis) luciferase activities were normalized by co-transfection with control (Renilla reniformis) luciferase plasmid. Compared to the wild type CGG haplotype, variant haplotypes CAG, CGC, and GAG drive luciferase expression at approximately 2x (p <0.0001), 1.4x (p <0.001) and 1.2x (p =0.08), respectively. This leads to the hypothesis that individuals carrying CAG or CGC haplotypes (17% of the population) exhibit higher levels of hENT1 expression and are more sensitive to Ara-C exposure. Experiments are underway to quantify gene transcripts in people of known hENT1 haplotypes. We also plan to genotype a large cohort of children with de novo AML for these three SNPs in hENT1 and correlate clinical outcomes in individuals carrying the low- versus the high-expressing haplotypes.
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Rajabi, Hasan, Maxwell Douglas Coll, Jacalyn Rosenblatt, Li Yin, Dina Stroopinsky, Katarina Luptakova, Baldev Vasir et al. "Mucin-1 (MUC1) Oncoprotein in Multiple Myeloma Cells Inhibits the Th1 Responses By Down Regulating the Expression of Mir-200c and up-Regulating the PDL1 Expression". Blood 124, n. 21 (6 dicembre 2014): 2072. http://dx.doi.org/10.1182/blood.v124.21.2072.2072.
Testo completoAbstract (sommario):
Abstract Introduction: The PDL1/PD-1 pathway is a critical mediator of immune escape in patients with multiple myeloma (MM). Regulation of this pathway has not been well characterized. MicroRNAs (miRNAs) are a conserved class of small (~22 nucleotides) RNAs that post-transcriptionally regulate gene expression by interacting with the 3′ untranslated region (3′ UTR) and, in some settings, coding regions of target mRNAs. MiRNAs suppress gene expression by promoting mRNA degradation or inhibiting translation. Of note, the 3’UTR of the PDL1 gene contains putative binding sites for miR-200 family of micro-RNA’s, suggesting a possible role of miR-200’s in regulation of PDL1 expression. We have previously demonstrated that miR-200c is suppressed by the MUC1 oncoprotein, and hypothesized that MUC1 expression on myeloma cells upregulates the expression of PDL1, via suppressing miR-200c. In the present study, we investigated the relationship between MUC1, miR-200c and PDL1 in multiple myeloma. Methods and Results: Lentivirus vectors expressing miR-200c or a control vector with green fluorescence protein (GFP) were transduced in two different MM cell lines (MM-RPMI, MM-U266). Cells were harvested sorted by Fluorescence-Activated Cell Sorting (FACS) after 72 hours of transduction, using a dual fluorescence for GFP and anti-PDL1 antibody to analyze the changes in PDL1 expression. MiR-200c transduction of U266 cells resulted in a decrease in mean expression of PDL1 from 69.55% to 1.4% (n=2). Similarly, RPMI cells demonstrated a reduction in mean expression of PDL1 from 62.5% to 1.9% (n=2) following miR-200c transduction. The abrogation of PDL1 expression in MM cells by ectopic expression of miR-200c was confirmed using western immunoblot analysis. Having previously demonstrated that miR-200c is suppressed by MUC1 in a solid tumor model, we evaluated the effect of silencing MUC1 in U266 and RPMI cell lines on miR-200c and PDL1 expression. MUC1 silenced stable cell lines of RPMI and U266 cells were generated using lentivirus shRNA vectors against MUC1 or a scrambled vector control. MUC1 silenced cells demonstrated an increase in miR-200c expression (> 2 fold, p value <0.05). Notably, PDL1 expression decreased from 52% to 3.7% and from 62.5% to 6.1% following silencing of MUC1 on U266 and RPMI cells respectively. Conclusions: Ectopic expression of micro-RNA miR-200c in RPMI-MM and U266-MM cell lines results in down regulation of PDL1 expression. Silencing MUC1 in RPMI-MM and U266-MM cell lines results in both increased expression of miR-200c and downregulation of PDL1 expression. These results support the hypothesis that MUC1 expression on myeloma cells contributes to tumor mediated immunosuppression, by suppressing miR-200c thereby enhancing PDL1 expression. Interfering with MUC1 mediated signaling represents a novel approach towards augmenting immune mediated targeting of myeloma. Disclosures No relevant conflicts of interest to declare.
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Straka, Małgorzata M., Samuel Schmitz e Hubert H. Lim. "Response features across the auditory midbrain reveal an organization consistent with a dual lemniscal pathway". Journal of Neurophysiology 112, n. 4 (15 agosto 2014): 981–98. http://dx.doi.org/10.1152/jn.00008.2014.
Testo completoAbstract (sommario):
The central auditory system has traditionally been divided into lemniscal and nonlemniscal pathways leading from the midbrain through the thalamus to the cortex. This view has served as an organizing principle for studying, modeling, and understanding the encoding of sound within the brain. However, there is evidence that the lemniscal pathway could be further divided into at least two subpathways, each potentially coding for sound in different ways. We investigated whether such an interpretation is supported by the spatial distribution of response features in the central nucleus of the inferior colliculus (ICC), the part of the auditory midbrain assigned to the lemniscal pathway. We recorded responses to pure tone stimuli in the ICC of ketamine-xylazine-anesthetized guinea pigs and used three-dimensional brain reconstruction techniques to map the location of the recording sites. Compared with neurons in caudal-and-medial regions within an isofrequency lamina of the ICC, neurons in rostral-and-lateral regions responded with shorter first-spike latencies with less spiking jitter, shorter durations of spiking responses, a higher proportion of spikes occurring near the onset of the stimulus, lower thresholds, and larger local field potentials with shorter latencies. Further analysis revealed two distinct clusters of response features located in either the caudal-and-medial or the rostral-and-lateral parts of the isofrequency laminae of the ICC. Thus we report substantial differences in coding properties in two regions of the ICC that are consistent with the hypothesis that the lemniscal pathway is made up of at least two distinct subpathways from the midbrain up to the cortex.
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Li, Cong, Yuming Liu e Rong Du. "The Effects of Review Presentation Formats on Consumers' Purchase Intention". Journal of Global Information Management 29, n. 6 (novembre 2021): 1–20. http://dx.doi.org/10.4018/jgim.20211101.oa46.
Testo completoAbstract (sommario):
Perception of products has becoming one of the most important factors influencing consumers’ purchase intention in the context of online shopping. Thus, enriching and studying review presentation formats have been significant things for practitioners and researchers. This study employed dual coding theory and telepresence theory to investigate the effects of review presentation formats (text-based reviews, image-based reviews and video-based reviews) on consumers’ purchase intention, and then analysed the moderation effect of product type. The 3×2 between-subject situational experiment and 3×2 within-subject eye-tracking experiment design were separately applied to test the hypotheses. The results manifested that review presentation formats exactly could generate different impacts on consumers’ purchase intentions. And product type moderated the impact of presentation formats on purchase intentions. Hence, this research considered online vendors should pay more attention to image-based and video-based reviews, moreover take the product type into account.
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Lim, Shok Ping, Donal McLornan, Nikolaos Ioannou, David Darling, Alan G. Ramsay, Joop Gäken e Ghulam J. Mufti. "Mir-181c Modulates T Cell Function By Regulating the Expression of BRK1". Blood 128, n. 22 (2 dicembre 2016): 132. http://dx.doi.org/10.1182/blood.v128.22.132.132.
Testo completoAbstract (sommario):
Abstract Introduction MicroRNAs (miRNAs) are short endogenous non-coding RNAs consisting of 18-25 nucleotides in length which influence gene expression and play pivotal roles in a diverse range of cellular processes. Aberrant miRNA expression has been implicated in a variety of cancers, including haematological malignancies. The miR-181 family plays a crucial role in haematopoiesis, including megakaryocytic, erythroid and myeloid differentiation and both B and T cell development and differentiation. We therefore focused our study on validating novel downstream targets of miR-181. Methods A novel functional assay utilising an optimised 3'UTR enriched library and a dual selection strategy (Gäken et al., 2012) was performed to identify biologically relevant targets of miR-181c. BRK1 (BRICK1, SCAR/WAVE Actin Nucleating Complex Subunit) was identified as a potential target and validation was performed by quantitative real time PCR and western blot analysis. Given the potential role of BRK1 in the Wiskott-Aldrich Syndrome Protein Family Verprolin-Homologous Protein-2 (WAVE2) complex and actin polymerisation in T cells, we investigated the influence of the miR-181c-BRK1 axis on T cell function. Knockdown of BRK1, using short hairpin RNA (shRNA) lentiviral vectors, and overexpression of miR-181c, via transfection with miR-181c expression vectors, were performed in Jurkat and primary T cells. T cell activation was examined by measurement of CD69 and CD154 expression and actin polymerisation was quantified by total cellular F-actin content. Immune synapse formation was studied by conjugate formation between T cells and antigen-pulsed B cells. Lastly, lamellipodia formation was investigated by assessing the ability of T cells to spread on anti-CD3 coated slides. Results Target genes downregulated by miR-181c were identified. One such target was BRK1, a component of the WAVE2 complex that has been shown to play a pivotal role in actin polymerisation. Validation experiments showed that overexpression and inhibition of miR-181c had no impact on BRK1 mRNA expression but did in fact modulate protein expression, suggesting that miR-181c regulates BRK1 at the translational level. We demonstrated that primary T cell activation resulted in downregulation of miR-181c and upregulation of BRK1 protein expression, further strengthening our hypothesis that the miR-181c-BRK1 axis may play an important role in T cell activation. Next, we found that loss of BRK1 resulted in reduced T cell activation as shown by decreased expression of CD69 and CD154. Furthermore, we showed that downregulation of BRK1 expression by shRNA resulted in reduced actin polymerisation after T cell stimulation. Reduced expression of BRK1 led to a marked reduction in the total area (in square micrometers) of F-actin accumulation at T cell contact sites and synapses with B cells indicating defective immune synapse formation. Moreover, reduced BRK1 expression resulted in defect in lamellipodia formation in response to T cell receptor stimulation. Similarly, ectopic expression of miR-181c in Jurkat T cells also led to a reduction in T cell activation and actin polymerisation coupled with defects in immune synapse and lamellipodia formation, hence confirming the important role of the miR-181c-BRK1 axis in T cell activation. Lastly, we demonstrated that suppression of BRK1 induced reduced expression of other pivotal proteins in the WAVE2 complex including WAVE2, Abi1 and Sra1. This suggests that impairment of actin polymerisation-dependent T cell functions were a result of instability of the WAVE2 complex following BRK1 suppression. Conclusion For the first time, we hereby demonstrate that BRK1 is a target of miR-181c. Moreover, we have highlighted the potential role of the miR-181c-BRK1 axis in impaired actin polymerisation-dependent T cell function and immune synapse formation. Deregulation of the miR-181c-BRK1 axis requires further evaluation in haematological malignancies. Disclosures No relevant conflicts of interest to declare.
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Barquist, Lars, Alexander J. Westermann e Jörg Vogel. "Molecular phenotyping of infection-associated small non-coding RNAs". Philosophical Transactions of the Royal Society B: Biological Sciences 371, n. 1707 (5 novembre 2016): 20160081. http://dx.doi.org/10.1098/rstb.2016.0081.
Testo completoAbstract (sommario):
Infection is a complicated balance, with both pathogen and host struggling to tilt the result in their favour. Bacterial infection biology has relied on forward genetics for many of its advances, defining phenotype in terms of replication in model systems. However, many known virulence factors fail to produce robust phenotypes, particularly in the systems most amenable to genetic manipulation, such as cell-culture models. This has particularly been limiting for the study of the bacterial regulatory small RNAs (sRNAs) in infection. We argue that new sequencing-based technologies can work around this problem by providing a ‘molecular phenotype’, defined in terms of the specific transcriptional dysregulation in the infection system induced by gene deletion. We illustrate this using the example of our recent study of the PinT sRNA using dual RNA-seq, that is, simultaneous RNA sequencing of host and pathogen during infection. We additionally discuss how other high-throughput technologies, in particular genetic interaction mapping using transposon insertion sequencing, may be used to further dissect molecular phenotypes. We propose a strategy for how high-throughput technologies can be integrated in the study of non-coding regulators as well as bacterial virulence factors, enhancing our ability to rapidly generate hypotheses with regards to their function. This article is part of the themed issue ‘The new bacteriology’.
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Scheinbaum, Angeline Close, Stefan Hampel e Mihyun Kang. "Future developments in IMC: why e-mail with video trumps text-only e-mails for brands". European Journal of Marketing 51, n. 3 (10 aprile 2017): 627–45. http://dx.doi.org/10.1108/ejm-09-2015-0624.
Testo completoAbstract (sommario):
Purpose Marketers use e-mail in new, potentially more informative, entertaining and lucrative ways – such as embedding video. The purpose of this paper is to examine consumer responses to audiovisual (i.e. text along with a short video) versus text-only messages in brand communication. Specifically, authors seek to uncover the efficacy of marketer-embedded video (vs text-only) in e-mail on the consumer's product interest, informativeness, perceived prestige, electronic word-of-mouth (e-WOM) intentions and willingness to pass the electronic message along digitally or on social media. With the dual coding theory and selective visual attention as theoretical guideposts, the intended contribution is a framework that can explain and predict advantages for multi-modal e-mail marketing communications. Design/methodology/approach Five hypotheses are tested experimentally with a one-factor experiment with two conditions (text-only vs audiovisual). The sample was 240 adult participants. Real brands (Audi and Apple) were used. For both brands, participants were randomly assigned to one of two conditions of the e-mail (i.e. audiovisual vs text-only). The stimuli are identical, with the exception of embedded video in the e-mail body. The videos are authentic brand videos, are approximately 50 s and use a product feature appeal. Participants’ pre-existing brand attitude was measured. Then, five dependent variables (product interest, informativeness, perceived prestige, e-WOM intentions and willingness to pass the electronic message along digitally or on social media) were considered with respect to consumer exposure to e-mail with video and text in the e-mail from the brand versus text-only e-mail from the brand. Findings The results supported the hypotheses that audiovisual messages (i.e. those with text and video) heighten informativeness, product interest, perceived prestige, intentions to spread e-WOM for a brand and willingness to pass along the e-mail along to friends and family when compared to text-only messages. These experimental findings from a one-factor experiment with two conditions (text-only vs audiovisual) are generally consistent for an American consumer technology brand Apple (iPhone) and a German luxury automobile brand Audi (S4). Hypotheses are supported for both brands (Apple and Audi), with the exception of product interest for Audi, which may be explained by the high price of a luxury automobile. Research limitations/implications An implication here for the dual coding theory is that the theory may be extended to consider what happens after the consumer codes the information with both the verbal and the non-verbal subsystem. The finding of interest to information processing scholars is that a video accompanying text communication from a brand to a consumer has an advantage over text-only communication. Brands that communicate with multi-modal marketing communication have better outcomes in informativeness, brand prestige perceptions and intentions of online consumer behaviors, including positive e-WOM for the brand in general and willingness to pass the specific content along in digital and social media platforms. Consumers can become brand advocates by being more inclined to forward the e-mails with the product short video as well as the e-mail text. Practical implications Brand marketers should consider e-mail in an integrated brand promotion (IBP) campaign as a cost advantage; one of the reasons e-mail should have a solid place in the IBP toolkit is due to e-mail's relatively low cost. The main cost comes with administration and production of the video. As a managerial implication for advertisers, embedding ads of a short video format in e-mails is a way to be more effective than plain-text e-mails. Short videos in e-mails are a reasonable idea to include in an integrated marketing communications effort (plausibly due to information processing with both a verbal and a non-verbal system). Brands can use videos in e-mails to enhance informativeness regarding products to enhance product differentiation from competitors. Yet, it is important to raise caution with some concerning disadvantages potentially associated with e-mail marketing and video. The three areas of caution include potential issues of privacy, clutter and technical inhibitors. Originality/value Despite the fact that e-mail is one of the most heavily used communication tools in marketing, there is scarce literature on e-mail and branding. By brands evoking a degree of prestige with embedded videos, consumer willingness to become part of the marketing communications is enhanced, as their e-WOM and willingness to share the branded content increase.
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Anderson, Benjamin A., e Scott A. Peterson. "Concreteness and levels of processing: a test of the dual-coding hypothesis using dynamic visual noise". Memory, 12 settembre 2022, 1–16. http://dx.doi.org/10.1080/09658211.2022.2120622.
Testo completo
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Anwesha Chakrabarti, Dr. Amrita Panda e Prof. Mallika Banerjee. "Uni-Representational Vs. Cross-Representational Difference in Imagery Formation: Verification of Dual Coding Theory". International Journal of Indian Psychology 3, n. 4 (25 settembre 2016). http://dx.doi.org/10.25215/0304.146.
Testo completoAbstract (sommario):
Dual coding theory states that information is stored by visual and verbal channel separately. During formation of imagery the visual and verbal channels are used distinctly. The study explores how retrieval of visual imageries of natural scenes varies with the variation in representational forms of encoding and recognition. Each stimulus set contained two different cards for encoding and recognition purpose. Both encoding and recognition of visual scenes were varied in both pictorial (picture form) and linguistic (word form) mode. Thus four plausible conditions are pictorial encoding associated with pictorial recognition, pictorial encoding and linguistic recognition; linguistic encoding and linguistic recognition and lastly, linguistic encoding with pictorial recognition. The aim of the study is to see whether the mode of object representation influences imagery formation. The aim of the study is to explore which kind of representation benefits recognition of imagery. 40 female University students (21 to 23 years) were selected and randomly assigned in to four experimental conditions. From each participant data was collected in the laboratory set up in a single session. Nine stimulus cards were presented to each subject. Presentation of a single stimulus card in encoding situation was followed by the recognition situation. The two way ANOVA result shows changing the representational forms has significant effects on retrieval. The present finding supports the notion of Dual coding hypothesis with an additional observation that poor retrieval in case of pictorial recognition when the information has been encoded linguistically.
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Lo, Wai Han, Benjamin Ka Lun Cheng e Shiqi Wang. "Effect of Virtual Reality News Presentation on News Learning". Electronic News, 19 ottobre 2022, 193124312211334. http://dx.doi.org/10.1177/19312431221133494.
Testo completoAbstract (sommario):
This is the first study in which the effects of viewing VR/360-degree video with and without a Cardboard device on news learning outcomes are examined. Cognitive load theory and the dual-coding hypothesis were adopted as the theoretical framework. An experiment was performed with 213 participants watching news clips. The findings show that the participants learned news information better from normal broadcast video or when they watched VR/360-degree video without a Cardboard device than when they watched VR/360-degree video with a Cardboard device. The theoretical and practical implications of these findings are discussed.
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Sarno, Stefania, Manuel Beirán, Joan Falcó-Roget, Gabriel Diaz-deLeon, Román Rossi-Pool, Ranulfo Romo e Néstor Parga. "Dopamine firing plays a dual role in coding reward prediction errors and signaling motivation in a working memory task". Proceedings of the National Academy of Sciences 119, n. 2 (6 gennaio 2022). http://dx.doi.org/10.1073/pnas.2113311119.
Testo completoAbstract (sommario):
Significance Recent studies have confirmed the role of dopamine firing in reward prediction error, even under perceptual uncertainty. However, little is known about dopamine behavior during the use of working memory or its role in motivation to work for reward. Here, we investigated these issues in a discrimination task. Fast dopamine responses reflected a perceptual bias while remaining consistent with the reward prediction error hypothesis. When the bias increased task difficulty, motivation positively correlated with both performance and dopamine activity. In addition, dopamine slowly ramped up in a motivation-dependent way during the working memory period. Characterizing dopamine neurons’ activity during tasks in which motivation influences behavior could importantly advance our knowledge of dopamine roles in effortful control.
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Joyner, David. "On quadratic residue codes and hyperelliptic curves". Discrete Mathematics & Theoretical Computer Science Vol. 10 no. 1, Combinatorics (1 gennaio 2008). http://dx.doi.org/10.46298/dmtcs.429.
Testo completoAbstract (sommario):
Combinatorics International audience For an odd prime p and each non-empty subset S ⊂ GF(p), consider the hyperelliptic curve X_S defined by y^2 = f_s(x), where f_s(x) = \P_{a2S} (x-a). Using a connection between binary quadratic residue codes and hyperelliptic curves over GF(p), this paper investigates how coding theory bounds give rise to bounds such as the following example: for all sufficiently large primes p there exists a subset S ⊂ GF(p) for which the bound |X_S(GF(p))| > 1.39p holds. We also use the quasi-quadratic residue codes defined below to construct an example of a formally self-dual optimal code whose zeta function does not satisfy the "Riemann hypothesis."
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Wang, Xin-jun, Lin Chen, Ran Xu, Si Li e Guang-cheng Luo. "DLEU7-AS1 promotes renal cell cancer by silencing the miR-26a-5p/coronin-3 axis". Clinical Kidney Journal, 28 febbraio 2022. http://dx.doi.org/10.1093/ckj/sfac061.
Testo completoAbstract (sommario):
ABSTRACT Long non-coding RNAs (lncRNAs) have been implicated in the progression and development of many types of cancer by interacting with RNA, DNA and proteins, including DLEU7-AS1. However, the function of DLEU7-AS1 in renal cell cancer (RCC) remains unclear. In this study, two in silico prediction algorithms were used to discover the potential target of miR-26a-5p, which was determined to be a tumor suppressor gene, possibly DLEU7-AS1, through the downregulation of coronin-3 in RCC. Thus, we hypothesized that DLEU7-AS1 promotes RCC by silencing the miR-26a-5p/coronin-3 axis. To test our hypothesis, we confirmed that DLEU7-AS1 directly targets miR-26a-5p using the pmirGLO dual-luciferase reporter assay. Next, we observed that DLEU7-AS1 expression was markedly upregulated in RCC samples and inversely correlated with clinical prognosis and miR-26a-5p levels. Knockdown of DLEU7-AS1 significantly suppressed the growth and metastasis of RCC cells in vitro and attenuated tumor growth in vivo. Interestingly, exogenous expression of coronin-3 or miR-26a-5p inhibitor treatment almost completely rescued the DLEU7-AS1 knockdown-induced inhibitory effects on cell proliferation, migration and invasion. In conclusion, our data demonstrate that DLEU7-AS1 is an oncogene in RCC capable of regulating the growth and metastasis of RCC by silencing the miR-26a-5p/coronin-3 axis, suggesting that DLEU7-AS1 can be employed as a potential therapeutic target and prognostic biomarker for RCC.
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Macias, Alvaro, Andrés González-Guerra, Ana I. Moreno-Manuel, Francisco M. Cruz, Nieves García-Quintáns, Lilian K. Gutiérrez, Marta Roche-Molina et al. "Abstract P356: Dual Dysfunction Of Kir2.1 Underlies Conduction And Excitation-contraction Coupling Defects Promoting Arrhythmias In A Mouse Model Of Andersen-tawil Syndrome Type 1". Circulation Research 129, Suppl_1 (3 settembre 2021). http://dx.doi.org/10.1161/res.129.suppl_1.p356.
Testo completoAbstract (sommario):
Background: Andersen-Tawil syndrome type 1 (ATS1), caused by trafficking deficient mutations in the gene KCNJ2 coding the inward rectifier K + channel Kir2.1, is associated with life-threatening arrhythmias, which in some patients resemble catecholaminergic polymorphic ventricular tachycardia (CPVT), but the mechanisms are poorly understood. We tested the hypothesis that dysfunction of two different populations of mutant Kir2.1 channels, one at the sarcolemma, and the other at the sarcoplasmic reticulum (SR) membrane, directly alters conduction and intracellular calcium dynamics, respectively, to promote the ATS1 phenotype and arrhythmias that resemble CPVT. Methods: We generated a new mouse model of ATS1 by a single i.v. injection of cardiac specific adeno-associated viral (AAV) transduction with Kir2.1 Δ314-315 . In-vivo and cellular, structural and functional analyses of the model were carried out by electrocardiogram (ECG), magnetic resonance imaging (MRI), intracardiac stimulation, patch-clamping, membrane fractionation, western blot, immunolocalization and live calcium imaging. Results: Our mouse model carrying mutant Kir2.1 Δ314-315 recapitulated the ATS1 phenotype without modifying ventricular function. On ECG, Kir2.1 Δ314-315 mice had prolonged PR, QRS and QT intervals and occasional U waves. They showed significantly slower conduction velocities than wildtype mice in response to flecaidine-induced Na + -channel blockade, additional QT prolongation in response to isoproterenol, and increased vulnerability to cardiac fibrillation. Cardiomyocytes from Kir2.1 Δ314-315 mice had significantly reduced inward rectifier K + and Na + inward currents, depolarized resting membrane potential and prolonged action potential duration. Immunolocalization in wildtype cardiomyocytes and skeletal muscle cells revealed a novel SR microdomain of functional Kir2.1 channels contributing to intracellular Ca 2+ homeostasis. Kir2.1 Δ314-315 cardiomyocytes showed defects in SR Kir2.1 localization and function, which contributed to abnormal spontaneous Ca 2+ release events. Conclusions: Cardiac-specific AAV transduction with Kir2.1 Δ314-315 in mice recapitulates the ATS1 phenotype by disrupting localization and function of Kir2.1 channels at the SR, and the Kir2.1-Na V 1.5 channelosome at the sarcolemma. These results reveal a novel dual mechanism of arrhythmogenesis in ATS1 involving defects in Kir2.1 channel trafficking and function at two different microdomains. They also provide the first demonstration at the molecular level of the mechanism underlying the overlap between ATS1 and CPVT associated with defects in intracellular calcium homeostasis.
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Kuo, Caroline C., Goodman Sibeko, Morayo Akande, Shaheema Allie, Nurain Tisaker, Dan J. Stein e Sara J. Becker. "Advancing a cascading train-the-trainer model of frontline HIV service providers in South Africa: protocol of an implementation trial". Addiction Science & Clinical Practice 16, n. 1 (30 aprile 2021). http://dx.doi.org/10.1186/s13722-021-00236-8.
Testo completoAbstract (sommario):
Abstract Background South Africa is marked by high rates of both HIV and alcohol use, and there is a detrimental synergistic relationship between these two epidemics. The Institute of Medicine recommends integrated care for alcohol use treatment and HIV, but implementation of integrated services remains a challenge in South Africa. This protocol describes a study designed to evaluate trainer, provider-, and patient encounter-level outcomes relating to the national rollout of a cascade train-the-trainer model of task-sharing to build capacity of the HIV workforce to deliver Screening, Brief Intervention, and Referral to Treatment (SBIRT) to address risky alcohol use. Methods This 5 year protocol consists of two phases. First, we will finalize development of a robust SBIRT train-the-trainer model, which will include an SBIRT Trainer Manual, Provider Resource Guide, fidelity observational coding system, case vignettes, and a curriculum for ongoing consultation sessions. Materials will be designed to build the capacity of novice trainers to train lay workers to deliver SBIRT with fidelity. Second, we will recruit 24–36 trainers and 900 providers in order to evaluate the effects of the SBIRT train-the-trainer model on trainer- (e.g., fidelity, knowledge), provider- (e.g., SBIRT attitudes, confidence, acceptability), and patient encounter- (e.g., proportion receiving screening, brief intervention, referral to treatment) level variables. Data on patient encounters will be tracked by providers on programmed tablets or scannable paper forms in real-time. Providers will report on SBIRT delivery on an ongoing basis over a 6-months period. Additionally, we will test the hypothesis that trainer-level factors will account for a substantial proportion of variability in provider-level factors which will, in turn, account for a substantial proportion of variability in patient encounter-level outcomes. Discussion This protocol will allow us to take advantage of a unique national training initiative to gather comprehensive data on multi-level factors associated with the implementation of SBIRT in HIV service settings. In the long-term, this research can help to advance the implementation of integrated alcohol-HIV services, providing lessons that can extend to other low-and-middle income countries confronting dual epidemics.
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"The Effects of Review Presentation Formats on Consumers’ Purchase Intention". Journal of Global Information Management 29, n. 6 (novembre 2021): 0. http://dx.doi.org/10.4018/jgim.20211101oa55.
Testo completoAbstract (sommario):
Perception of products has becoming one of the most important factors influencing consumers’ purchase intention in the context of online shopping. Thus, enriching and studying review presentation formats have been significant things for practitioners and researchers. This study employed dual coding theory and telepresence theory to investigate the effects of review presentation formats (text-based reviews, image-based reviews and video-based reviews) on consumers’ purchase intention, and then analysed the moderation effect of product type. The 3×2 between-subject situational experiment and 3×2 within-subject eye-tracking experiment design were separately applied to test the hypotheses. The results manifested that review presentation formats exactly could generate different impacts on consumers’ purchase intentions. And product type moderated the impact of presentation formats on purchase intentions. Hence, this research considered online vendors should pay more attention to image-based and video-based reviews, moreover take the product type into account.
38
Zheng, Lei, Liying Kang, Yan Cheng, Junli Cao, Lijie Liu, Hongmei Xu e Liming Gao. "Tumor Inhibitory Effect of Long Non-coding RNA LOC100505817 on Gastric Cancer". Pathology and Oncology Research 27 (26 maggio 2021). http://dx.doi.org/10.3389/pore.2021.581542.
Testo completoAbstract (sommario):
Gastric cancer (GC) is one of the major malignancies worldwide. Emerging evidence has revealed the potential involvement of long noncoding RNA (lncRNA) in human genetic disorders and cancer, but the role of LOC100505817 remains unknown. Thus, in this study, we isolated tissues from GC patients to characterize the functional importance of LOC100505817 in GC tumorigenesis. We also proposed a hypothesis that the regulation of Wnt/β-catenin pathway by LOC100505817 was regulated by miR-20a-mediated WT1. After the collection of cancer tissues and adjacent tissues were obtained from GC patients, expression of LOC100505817, Wnt/β-catenin pathway- and EMT-related genes was quantified. Ectopic expression and knockdown experiments were applied in order to investigate the protective role of LOC100505817 in the progression of GC. Subsequently, cell viability, flow cytometry for apoptosis and cell cycle were detected via CCK-8, while migration and invasion were determined using scratch test and Transwell assay respectively. Then interactions among LOC100505817, miR-20a and WT1 were explored by dual luciferase reporter gene assay, RNA pull down assay and RNA binding protein immunoprecipitation (RIP) assay. The results found poor expression LOC100505817 was poorly expressed in GC cells and tissues. Overexpressed LOC100505817 resulted in the significant reduction of cell proliferation, migration and invasion as well as the expression of Wnt2b, β-catenin, CyclinD1, N-cadherin, Vimentin and snail, while increased cell apoptosis along with the expression of E-cadherin. Wnt/β-catenin pathway and EMT in GC cells were suppressed by LOC100505817 through miR-20a-inhibted WT1. In summary, our results provided evidence suggesting that LOC100505817 inhibits GC through LOC100505817-mediated inhibition of Wnt/β-catenin pathway, that leads to the overall restraining of GC cell proliferation, migration and invasion through miR-20a-reduced WT1.