Articoli di riviste: "Digestive organs Surgery"

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KOMODA, Takeshi, Satoshi TANAKA, Takashi MAEBA, Shinya YAMAMOTO, Tomoji KOHMOTO, Keizou CHIKAISHI e Hajime KUMEGAWA. "ENTEROCOCCAL INFECTION FOLLOWING SURGERY OF THE DIGESTIVE ORGANS". Journal of the Japanese Practical Surgeon Society 50, n. 2 (1989): 248–53. http://dx.doi.org/10.3919/ringe1963.50.248.

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Maehara, Yoshihiko, Shunji Kohnoe e Keizo Sugimachi. "Chemosensitivity test for carcinoma of digestive organs". Seminars in Surgical Oncology 6, n. 1 (1990): 42–47. http://dx.doi.org/10.1002/ssu.2980060109.

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Coffey, J. Calvin, Dara Walsh, Kevin G. Byrnes, Werner Hohenberger e Richard J. Heald. "Mesentery — a ‘New’ organ". Emerging Topics in Life Sciences 4, n. 2 (15 giugno 2020): 191–206. http://dx.doi.org/10.1042/etls20200006.

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The mesentery is the organ in which all abdominal digestive organs develop, and which maintains these in systemic continuity in adulthood. Interest in the mesentery was rekindled by advancements of Heald and Hohenberger in colorectal surgery. Conventional descriptions hold there are multiple mesenteries centrally connected to the posterior midline. Recent advances first demonstrated that, distal to the duodenojejunal flexure, the mesentery is a continuous collection of tissues. This observation explained how the small and large intestines are centrally connected, and the anatomy of the associated peritoneal landscape. In turn it prompted recategorisation of the mesentery as an organ. Subsequent work demonstrated the mesentery remains continuous throughout development, and that abdominal digestive organs (i.e. liver, spleen, intestine and pancreas) develop either on, or in it. This relationship is retained into adulthood when abdominal digestive organs are directly connected to the mesentery (i.e. they are ‘mesenteric' in embryological origin and anatomical position). Recognition of mesenteric continuity identified the mesenteric model of abdominal anatomy according to which all abdominal abdomino-pelvic organs are organised into either a mesenteric or a non-mesenteric domain. This model explains the positional anatomy of all abdominal digestive organs, and associated vasculature. Moreover, it explains the peritoneal landscape and enables differentiation of peritoneum from the mesentery. Increased scientific focus on the mesentery has identified multiple vital or specialised functions. These vary across time and in anatomical location. The following review demonstrates how recent advances related to the mesentery are re-orientating the study of human biology in general and, by extension, clinical practice.

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Goseki, Narihide, Yuzuru Hara, Togo Aoi, Takeshi Nagahama, Yasuyuki Dobashi, Tokichi Gen, Tohru Kawamura, Hiroshi Nakamura, Tohru Takiguchi e Mitsuo Endo. "Enteral Nutritional Support for Major Surgery of the Digestive Organs." Japanese Journal of Gastroenterological Surgery 26, n. 4 (1993): 1169–74. http://dx.doi.org/10.5833/jjgs.26.1169.

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Bochkova, T. V., e A. Kh Gainullin. "Autoplasma as a Hemostatic Agent for Endoscopic Surgery of Hollow Organs". Creative surgery and oncology 10, n. 3 (30 novembre 2020): 212–16. http://dx.doi.org/10.24060/2076-3093-2020-10-3-212-216.

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Introduction. To maximize the effectiveness of hemostatic technologies, it is necessary to optimize local hemostasis through hybrid and controlled approaches, as well as to improve the conditions for tissue surgical dissection preventing perforation of hollow organs. This study is aimed at assessing the efficacy of stopping bleeding and the safety of resection of digestive hollow organs in experimental models of trauma to abdominal organs in laboratory animals.Materials and methods. Experiments were carried out in vivo on 20 rabbits. All animals were divided into 4 experimental groups (5 animals each): I — the control group, in which no methods for stopping bleeding were used; II — the group, in which infiltration of the wall of a hollow organ with saline solution was used; III — the group, in which physical hemostasis was applied using an electrosurgical unit and an argon plasma coagulation apparatus; IV — the group, animals in which underwent controlled local biological hemostasis using autoplasma. Prior to laparotomy, 2–3 ml of whole blood was taken from the rabbit’s ear for preliminary preparation of autoplasma. The prepared autoplasma was introduced into the area of resection or other operation of the mucous membrane of the rabbit’s digestive tract.Results and discussion. Although no statistical difference in the time of stopping bleeding was observed between the control (I) and saline (II) groups, one more episode of bleeding was noted in group II. Preventive local administration of autoplasma (group IV) was established to have a high hemostatic potential. As expected, electrocoagulation was more effective than saline; however, hemostasis achieved by means of argon plasma coagulation is characterized by rapid formation of a necrotic zone, which may lead to undesirable consequences in the long-term period.Conclusion. Preventive local administration of autoplasma and recombinant human protein has a high hemostatic potential in animals. In comparison, electrocoagulation is less effective due to the rapid filling of the pathological focus with blood.

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Laskovets, R. S., e T. N. Gryazneva. "THE FUNCTIONALITY OF THE GASTROINTESTINAL TRACT OF DOGS AT USING PROBIOTIC THERAPY IN POSTOPERATIVE PERIOD". Problems of Veterinary Sanitation, Hygiene and Ecology 1, n. 4 (2019): 468–73. http://dx.doi.org/10.36871/vet.san.hyg.ecol.201904020.

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The article presents the materials reflecting the functional features of the gastrointestinal tract of dogs after surgery on the organs of the digestive system. Probiotic therapy was used as a method of recovery of gastrointestinal microbiocenosis in the postoperative period.

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Bogormistrova, Veronika A., Pavel N. Svoboda, Vera N. Shestakova, Alexander A. Udovenko e Denis V. Sosin. "The structure of lesions of the musculoskeletal system in adolescent children, considering the somatic pathology and living environment". Pediatric Traumatology, Orthopaedics and Reconstructive Surgery 10, n. 1 (15 gennaio 2022): 5–12. http://dx.doi.org/10.17816/ptors96525.

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BACKGROUND: Pathology of the musculoskeletal system ranks first among health disorders of the younger generation. The frequency of posture disorders, scoliosis, and flat feet increases as the child grows older and requires careful monitoring, preventive measures, and long-term rehabilitation measures. AIM: This investigation studies the formation frequency of lesions of the musculoskeletal system lesions, considering the somatic pathology in adolescent children brought up under various conditions, and addresses the issue of preventive and corrective measures. MATERIALS AND METHODS: The main group consisted of schoolchildren aged 1115 from social institutions (n = 60). The comparison group included children from complete families (n = 60). The health assessment was conducted in accordance with the methodological recommendations developed at the Research Institute of Hygiene of Children and Adolescents. The material was copied from forms 112/y, 003/y, 026/y, and the clinical examination results and the conclusions of other specialists were collected. Statistics were evaluated by the Pearsons 2-criterion with the Yates correction, with values of p 0.05. RESULTS: The health of children from social institutions was significantly worse than that of complete families (p = 0.04). They were 4.8 times more likely to form chronic diseases (p = 0.04), especially those of the central nervous and musculoskeletal systems, digestive organs, blood circulation, and the ear, nose, and throat (ENT) organs were leading (p = 0.001). Lesions of the musculoskeletal system were more often combined (p = 0.02). In the comparison group, functional disorders occurred more often (p = 0.04), and digestive and circulatory organ diseases prevailed. Pathology of the musculoskeletal system occupied the third position and was significantly less common (p = 0.0001). CONCLUSIONS: The health of children from social institutions is worse than that of schoolchildren from complete families. In them, lesions of the musculoskeletal system occupy second place, the frequency of combined lesions is higher, the increase in orthopedic pathology occurs mainly because of scoliosis, flat feet, and posture disorders. Neurodysplastic and idiopathic forms prevail in the structure of scoliosis. In children with scoliosis, diseases of the central nervous system, digestive organs, and blood circulation are more often registered. In children with flat feet, lesions of the digestive and circulatory organs are more often diagnosed. In children with impaired posture, diseases of ENT organs, circulatory organs, and vision are more often detected. Therefore, the musculoskeletal system pathology must be considered as an interdisciplinary problem, requiring a comprehensive rehabilitation program that involves other specialists.

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Bunni, J., J. C. Coffey e M. F. Kalady. "Resectional surgery for malignant disease of abdominal digestive organs is not surgery of the organ itself, but also that of the mesenteric organ". Techniques in Coloproctology 24, n. 7 (2 aprile 2020): 757–60. http://dx.doi.org/10.1007/s10151-020-02197-7.

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Rudant, Jérémie, Axelle Dupont, Yann Mikaeloff, Francis Bolgert, Joël Coste e Alain Weill. "Surgery and risk of Guillain-Barré syndrome". Neurology 91, n. 13 (24 agosto 2018): e1220-e1227. http://dx.doi.org/10.1212/wnl.0000000000006246.

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ObjectiveTo assess the association between Guillain-Barré syndrome (GBS) and recent surgery based on French nationwide data.MethodsData were extracted from the French health administrative databases (SNIIRAM/PMSI). All patients hospitalized for GBS between 2009 and 2014 were identified by ICD-10 code G61.0 as main diagnosis. Patients previously hospitalized for GBS in 2006, 2007, and 2008 were excluded. Surgical procedures were identified from the hospital database. Hospitalizations for surgery with no infection diagnosis code entered during the hospital stay were also identified. The association between GBS and a recent surgical procedure was estimated using a case-crossover design. Case and referent windows were defined as 1–60 days and 366–425 days before GBS hospitalization, respectively. Analyses were adjusted for previous episodes of gastroenteritis and respiratory tract infection, identified by drug dispensing data.ResultsOf the 8,364 GBS cases included, 175 and 257 patients had undergone a surgical procedure in the referent and case windows, respectively (adjusted odds ratio [OR] = 1.53, 95% confidence interval [CI]: 1.25–1.88). A slightly weaker association was observed for surgical procedures with no identified infection during the hospitalization (OR = 1.40, 95% CI: 1.12–1.73). Regarding the type of surgery, only surgical procedures on bones and digestive organs were significantly associated with GBS (OR and 95% CI = 2.78 [1.68–4.60] and 2.36 [1.32–4.21], respectively).ConclusionIn this large nationwide epidemiologic study, GBS was moderately associated with any type of recent surgery and was more strongly associated with bone and digestive organ surgery.

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Akhmetzyanov, F. Sh, N. A. Valiev, V. I. Egorov e M. I. Shaymardanov. "The option of surgery for gastric stump cancer in patients who have previously undergone pancreaticoduodenectomy". Kazan medical journal 102, n. 1 (10 febbraio 2021): 100–103. http://dx.doi.org/10.17816/kmj2021-100.

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Gastric stump cancer is a carcinoma which forms no earlier than 5years after surgery for benign disease. The incidence ranges from 2.4 to 5% among patients with stomach cancer. Previous operations lead to the emergence of an adhesive process in the abdominal cavity, changes in the anatomy and topography of the abdominal organs, as well as the development of new ways of lymph outflow. These factors lead to the re-surgery becomes technically more complicated and requires high professional training from the surgeon. Of particular surgical interest is the issue of restoration of the digestive tract, which directly depends on the nature and volume of the previous surgery. In this paper, the authors describe cases of surgical treatment of gastric stump cancer in two patients, who had previously undergone pancreaticoduodenectomy.

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Takahashi, Masanori, Masanori Terashima, Akinori Takagane, Kenichi Oyama, Hisataka Fujiwara e Go Wakabayashi. "Ghrelin and leptin levels in cachectic patients with cancer of the digestive organs". International Journal of Clinical Oncology 14, n. 4 (agosto 2009): 315–20. http://dx.doi.org/10.1007/s10147-008-0856-1.

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Konno, Tetsuro, Fumio Sano, Hiroshi Shiroto, Hiromitsu Noto, Kenju Kusumoto, Naoki Sato, Osamu Nishida, Yoshinobu Hata, Masami Nakanishi e Junichi Uchino. "Clinical application and its appraisal of the laser surgery to advanced carcinoma of the digestive organs". JOURNAL OF JAPAN SOCIETY FOR LASER SURGERY AND MEDICINE 5, n. 3 (1985): 31–35. http://dx.doi.org/10.2530/jslsm1980.5.3_31.

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Sumiyama, Yoshinobu, e Takashi Yokoyama. "Issues Related to the Use of Antibacterial Agents in the Field of Surgery of Digestive Organs." Japanese Journal of Gastroenterological Surgery 27, n. 10 (1994): 2358–67. http://dx.doi.org/10.5833/jjgs.27.2358.

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Konno, Hiroyuki, Hiroshi Kaneko, Takashi Hachiya, Yuji Yaruo, Tatsuo Tanaka, Shohati Suzuki, Satoshi Nakamura e Shozo Baba. "Surgical management for a malignancy of the digestive organs accompanied with an abdominal aortic aneurysm". Surgery Today 28, n. 9 (settembre 1998): 988–91. http://dx.doi.org/10.1007/s005950050269.

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MOSTAPHA, El FDILI EL, Tarik Souiki, Karim IBN Majdoub, Imane Toughrai e Khalid Mazaz. "Surgical Approach to Splenic Hydatid Cyst: A Case Report". SAS Journal of Surgery 7, n. 11 (16 novembre 2021): 674–78. http://dx.doi.org/10.36347/sasjs.2021.v07i11.009.

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Hydatid disease, or echinococcosis, is a widespread zoonotic parasitic disease caused by a tapeworm, It is most frequently caused by Echinococcus granulosus, and the liver is the most commonly involved organ, although it may affect other organs. Hydatid disease of the spleen is a rare condition with a worldwide incidence of 0.5–4% [10]. Hydatid cyst of the ovary is an extremely rare presentation and accounts for 0.2–1% of the diagnosed cases. It may be mistaken for ovarian cysts or cystic tumors of the ovary[1], We present here a case report about a female patient who was admitted in gynecologic service for cystic tumor of ovary revealed by ultrasound and CT and operated by the realization of hysterectomy and adnexectomy the macroscopic and microscopic exam reveals that the lesion is a hydatid cyst, the CT objectifies also a splenic hydatid cyst and the patient was transferred to the digestive surgery department for further management for surgery and the treatment was a total splenectomy.

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Putra, Yuliaji Narendra, Tubagus Odih Rhomdani Wahid, Guntur Surya Alam e Rohadi Rohadi. "Bochdalek Hernia". JBN (Jurnal Bedah Nasional) 2, n. 2 (20 settembre 2018): 40. http://dx.doi.org/10.24843/jbn.2018.v02.i02.p01.

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Background: Bochdalek hernia is a congenital defect on posterolateral diaphragm with an abnormal connection between the thoracic cavity and the abdominal cavity. This disease causes protrusion of abdominal organs into the thoracic cavity. Case: an 8-day-old baby girl admitted to hospital with shortness of breath 24 hours after delivered. The baby was born spontaneously assisted by midwife. Upon born, the baby was crying strongly and meconium came out 2 hours after birth. On physical examination, the abdomen was inspected flat. Darm contour and darm steifung was observed, and peristaltic sound was heard on left lung. Radiological examination demonstrated a diaphragmatic hernia with ileus obstruction. The patient underwent laparatomy and stomach, ileum, transverse colon, and spleen, was found on foramen Bochdalek. Post-surgery chest X Ray showed favourable result. Ten days after treatment, the patient was discharged in a good condition with no respiratory or digestive problems. After 1 months the patient’s condition remained good and there were no respiratory or digestive complaints. Conclusion: In a rare case like Bochadalek hernia, laparotomy performed as a promising attempt to return the anatomic position of organ.

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HAMADA, TSUTOMU. "Endoscopic treatment of digestive organs disease. 4. Contact between early gastric cancer endoscopic removal treatment and surgery." Nihon Naika Gakkai Zasshi 85, n. 9 (1996): 1446–49. http://dx.doi.org/10.2169/naika.85.1446.

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Kyeong Kim, Mi, Junoik Shin, Jeong-Hyun Choi e Hee Yong Kang. "Low-dose combined spinal-epidural anesthesia for a patient with a giant hiatal hernia who underwent urological surgery". Journal of International Medical Research 46, n. 10 (29 agosto 2018): 4354–59. http://dx.doi.org/10.1177/0300060518793800.

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A hiatal hernia refers to herniation of the abdominal organs through the esophageal hiatus of the diaphragm. A giant hiatal hernia affects digestive and cardiopulmonary function by compressing the organs. We report a patient who had low-dose combined spinal and epidural anesthesia (CSEA) for safe and effective anesthesia for conservative treatment of a giant hiatal hernia. An 84-year-old woman who had a giant hiatal hernia was scheduled for ureteroscopic removal of a ureteral stone. CSEA was performed at the L4 to L5 lumbar interspace and an epidural catheter tip was placed 5 cm cephalad from the inserted level. The T12 block was checked after 10 minutes of intrathecal injection of 6 mg of 0.5% bupivacaine. The T10 block was checked after additional injection of 80 mg of 2% lidocaine through the epidural catheter. During anesthesia and surgery, the patient's vital signs remained stable and the operation was completed within 1 hour without any problems. In conclusion, low-dose CSEA may be safely used without any cardiopulmonary and gastrointestinal problems in patients with a giant hiatal hernia undergoing urological surgery.

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Bagaturiya, Georgy Otarovich, e Anna Anatolievna Pashko. "At the root of SPbSPMU: by memory of the founder of the Department of Operational surgery and topographic anatomy prof. F. I. Valker". Pediatrician (St. Petersburg) 6, n. 4 (15 dicembre 2015): 154–59. http://dx.doi.org/10.17816/ped64154-159.

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This article is about a scientist, a surgeon, an anatomist, a founder of the doctrine of the development of organs and systems of human after birth. It is based on archival and printed sources. His role as an important organizer, founder and a head of the department of operative surgery and topographic anatomy of the Leningrad Pediatric Medical Institute is mentioned. He was the closest student and a follower of of Professor V. N. Shevkunenko he made a significant contribution to the study of the morphological features of organs and systems during humans postnatal development. His outstanding abilities as an organizer and teacher are shown on the example of a creation of the department of operative surgery in Tashkent Medical Institute and in Leningrad Pediatric Institute, and also on being an acting head of the department of operative surgery and topographic anatomy at the Military Medical Academy during evacuation in the time of the Great Patriotic War, and participating in the organization of assistance to the wounded solders during the Civil, the Finnish wars. His style of teaching, the principles on which he built his relationship with colleagues, students, doctors, and his role in educating of a whole generation of well known scientists and teachers is shown. A large number of anatomical facts of the development of organs and systems of human, obtained by F. I. Valker was summed up in his life's work: "Development of a human after birth" (1951). The evolution of the postnatal development of the nervous, cardiovascular and urinary systems, as well as respiratory and digestive systems is shown in this big work. This doctrine is still of a practical an theoretical importance for doctors of many specialties, especially pediatricians and pediatric surgeons.

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Uzdenov, Marat B. "Justification for use of selenium-modified mineral water in medical rehabilitation of patients who underwent colon surgery due to malignant tumor (overview)". Russian Journal of Physiotherapy, Balneology and Rehabilitation 18, n. 6 (15 dicembre 2019): 396–400. http://dx.doi.org/10.17816/1681-3456-2019-18-6-396-400.

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The article presents the justification for the use of selenium-modified low-mineralized mineral water of Chapaevsk deposit (the Karachay-Cherkess Republic), modified by selenium. It describes its effect on the state of hormonal and immune status, antioxidant system in malignant diseases of digestive organs, prevention of complications, reduction of dose of used medicines, improvement of quality of life of this category of patients. Conclusion. It is noted that the use of selenium-modified low-mineralized mineral water expands and complements the possibilities of rehabilitation and rehabilitation assistance to patients who have undergone operations on the large intestine in case of malignant neoplasms.

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Buzás, György Miklós. "History of the development of tumor markers of the digestive tract cancers". Orvosi Hetilap 154, n. 21 (maggio 2013): 810–19. http://dx.doi.org/10.1556/oh.2013.29611.

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Tumor markers are gene products which signal the occurrence of tumors in different organs as well as their response to surgery and chemotherapy. The discovery of tumor markers occurred after the demonstration of tumor-specific transplantation antigens in chemically or virally induced tumors in syngenic rodents. The history of currently used tumor markers began in the 1940s, the first discovered being alpha-fetoprotein in 1956, followed by that of carcinoembryonic antigen in 1965. Since then the range of tumor markers has widened continously. Their chemical structure and genetics is now well known. Some may play part in tumor growth and development of metastases. The potential uses of tumor markers are general or high risk population screening, adjunct in diagnosis of cancer, preoperative indicator of tumor burden, indicator of therapeutic success, evidence of postoperative recurrences and use in tumor localization. However, there is no ideal tumor marker fulfilling all the criteria. Isotope-labeled anti-carcinoembryonic antigen antibodies and small molecular E-selectin inhibitors could play a role in the molecular radio- and chemotherapy of colon and pancreatic carcinomas. Orv. Hetil., 2013, 154, 810–819.

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Usenko, O., Ya Voitiv e S. Shcherbyna. "Method of diagnostics of undifferentiated connective tissue dysplasia". Bukovinian Medical Herald 25, n. 2(98) (26 agosto 2021): 114–18. http://dx.doi.org/10.24061/2413-0737.xxv.2.98.2021.18.

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Objective – to develop a method for diagnosing undifferentiated connective tissue dysplasia (UCTD) in patients with surgical pathology.Material and methods. The object of the study comprises 96 patients with surgical pathology who were treated in the department of thoracoabdominal surgery of the Shalimov National Institute of Surgery and Transplantology during 2017-2020 and 20 practically healthy people (comparison group). Laboratory, instrumental, histological, immunohistochemical studies and statistical analysis were performed.Results. The developed method contains an assessment of the most informative phenotypic and visceral signs of connective tissue pathology. The main attention is paid to the features that characterize the visceral manifestations of UDCT, especially functional and morphological changes of the digestive organs, which is extremely important in abdominal surgery. Ultrasonography is used to analyze the width of the white line of the abdomen and the condition of the abdominal and retroperitoneal organs, determining the presence of diastase of the rectus abdominis and splanchnoptosis. Studies of the effectiveness of the proposed method have shown that it can be used to diagnose UDCT in patients with surgical pathology, which is necessary to select effective treatment tactics and prevent complications in such patients.Conclusions. A method for diagnosing undifferentiated connective tissue dysplasia has been developed, which evaluates the most informative phenotypic signs of connective tissue pathology and considers the peculiarities of pathology in patients of a surgical hospital.

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McBurney, Michael L. "The gut: central organ in nutrient requirements and metabolism". Canadian Journal of Physiology and Pharmacology 72, n. 3 (1 marzo 1994): 260–65. http://dx.doi.org/10.1139/y94-040.

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The gut is an important organ, which not only digests and absorbs food but selectively excludes bacteria and toxins from entering the body. It has one of the highest rates of protein turnover of any tissue in the body. Maintenance of epithelial cell proliferation and secretory, digestive, and gut-associated lymphatic tissues (GALT) function requires a constant supply of substrates. A primary feature of the metabolic response to fasting, accidental injury, or surgery is accelerated skeletal muscle proteolysis and translocation of amino acids from the periphery to visceral organs. Nevertheless, the serosal supply of nutrients may be inadequate to maintain normal gut barrier function. The following factors influencing gut nutrient requirements and the effect of the gut on the whole-body metabolism are discussed: (i) diet composition and gut mass, (ii) physiological and pathologic nutrient requirements of epithelial and GALT cells, (iii) route of nutrition (enteral versus parenteral), and (iv) nutrient inadequancy and gut barrier dysfunction (structural or immune mediated).Key words: gastrointestine, metabolism, gut-associated lymph tissue, glutamine, short-chain fatty acids.

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Vítek, Libor, e Martin Haluzík. "The role of bile acids in metabolic regulation". Journal of Endocrinology 228, n. 3 (5 gennaio 2016): R85—R96. http://dx.doi.org/10.1530/joe-15-0469.

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Bile acids (BA), long believed to only have lipid-digestive functions, have emerged as novel metabolic modulators. They have important endocrine effects through multiple cytoplasmic as well as nuclear receptors in various organs and tissues. BA affect multiple functions to control energy homeostasis, as well as glucose and lipid metabolism, predominantly by activating the nuclear farnesoid X receptor and the cytoplasmic G protein-coupled BA receptor TGR5 in a variety of tissues. However, BA also are aimed at many other cellular targets in a wide array of organs and cell compartments. Their role in the pathogenesis of diabetes, obesity and other ‘diseases of civilization’ becomes even more clear. They also interact with the gut microbiome, with important clinical implications, further extending the complexity of their biological functions. Therefore, it is not surprising that BA metabolism is substantially modulated by bariatric surgery, a phenomenon contributing favorably to the therapeutic effects of these surgical procedures. Based on these data, several therapeutic approaches to ameliorate obesity and diabetes have been proposed to affect the cellular targets of BA.

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Godinjak, Zulfo, Edin Idrizbegović e Kerim Begić. "Laparoscopy After Previous Laparotomy". Bosnian Journal of Basic Medical Sciences 6, n. 4 (20 novembre 2006): 45–47. http://dx.doi.org/10.17305/bjbms.2006.3119.

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Following the abdominal surgery, extensive adhesions often occur and they can cause difficulties during laparoscopic operations. However, previous laparotomy is not considered to be a contraindication for laparoscopy. The aim of this study is to present that an insertion of Veres needle in the region of umbilicus is a safe method for creating a pneumoperitoneum for laparoscopic operations after previous laparotomy. In the last three years, we have performed 144 laparoscopic operations in patients that previously underwent one or two laparotomies. Pathology of digestive system, genital organs, Cesarean Section or abdominal war injuries were the most common causes of previouslaparotomy. During those operations or during entering into abdominal cavity we have not experienced any complications, while in 7 patients we performed conversion to laparotomy following the diagnostic laparoscopy. In all patients an insertion of Veres needle and trocar insertion in the umbilical region was performed, namely a technique of closed laparoscopy. Not even in one patient adhesions in the region of umbilicus were found, and no abdominal organs were injured.

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Polianskyi, I., e V. Moskaliuk. "GENETIC DETERMINATION OF POSTOPERATIVE INTESTINAL PARESIS IN THE BACKGROUND OF PERITONITIS". Clinical anatomy and operative surgery 19, n. 3 (26 novembre 2020): 13–16. http://dx.doi.org/10.24061/1727-0847.19.3.2020.34.

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Postoperative intestinal paresis remains an urgent problem of abdominal surgery, since it is one of the most common postoperative complications in terms of frequency. In most studies, the violation of the motor function of the intestine after surgery on the hollow organs of the digestive system is considered as a pathological process, is a consequence of postoperative peritonitis. The paper presents data on the relationship between the variants of the SERT gene, which regulates the reuptake of serotonin, with the concentration in the blood plasma and the likelihood of postoperative intestinal paresis and peritonitis. This made it possible not only to predict the occurrence of postoperative disorders of the motor-evacuation function of the intestine, but also to improve the algorithms for their prevention and pathogenetically justified treatment. It has been established that it is with the SS-genotype that postoperative disorders of the motor-evacuation function of the intestine occur more often, which lead to peritonitis. This leads to a change in treatment tactics in such patients. If these unfavorable genotype variants are found for surgery in such patients, we consider it expedient to expand the indications for intestinal intubation even without intraoperative manifestations of its paresis. We have proposed a technique in which nasointestinal intubation of the small intestine is first performed, which is necessary for the main stage of the operation. If it is necessary to withdraw the stoma, the indications for which in patients with unfavorable genotype variants are considered appropriate to expand, the intubation probe is cut off at the first opening, which is placed in the stomach, and the other end is withdrawn through the stoma. This greatly simplifies the technique of bowel intubation, avoids various complications associated with retrograde intubation, and, first of all, wound infection. Studies indicate a high risk of developing postoperative peritonitis in surgical patients who, after surgical interventions on the digestive organs, had pronounced disorders of the motor-evacuation function of the intestine. Improved algorithms for the treatment of such patients make it possible to significantly reduce the risk of developing postoperative intestinal paresis and peritonitis, and, if they occur, to effectively eliminate their manifestations.

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Li, Juan, Chi Mao, Lian Ma e Xia Zhou. "Giant sublingual hamartoma with medial cleft tongue: a case report and literature review". Journal of International Medical Research 48, n. 8 (agosto 2020): 030006052094208. http://dx.doi.org/10.1177/0300060520942089.

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Hamartomas commonly occur in respiratory and digestive organs, such as the lungs, pancreas, and liver; they rarely occur in the oral cavity, especially in the sublingual region. This report describes a 5-month-old boy who presented with a giant sublingual hamartoma and medial cleft tongue. He underwent corrective operations at 5 months, 11 months, and 31 months of age. Histopathological analysis revealed features suggestive of hamartoma. There have been no signs of recurrence. The boy exhibited normal speech development at 3 years of age; all other oral functions were unaffected at that time. This report includes a review of relevant literature. The findings in this report and previous literature suggest that a multidisciplinary approach, carefully planned staged surgery, and rehabilitation are needed to achieve favorable outcomes in patients with hamartoma in the oral cavity.

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Hryn, Volodymyr H., Vitaliy S. Drabovskiy, Dmytro A. Sytnik, Roman M. Ryabuschko, Serhii M. Bilash e Bohdan I. Gonzhak. "PECULIARITIES OF MORPHOETIOPATHOGENESIS OF ACUTE APPENDICITIS AND CONSEQUENCES AFTER APPENDECTOMY". Wiadomości Lekarskie 75, n. 6 (2022): 1492–99. http://dx.doi.org/10.36740/wlek202206112.

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The aim: To study the features of morphoethiopathogenesis of acute appendicitis and the consequences after appendectomy. Materials and methods: 10 preparations of human appendix were studied, from which 5 appendixes were normal in people who died in adulthood and old age and 5 processes were taken intraoperatively during appendectomy. Morphometric characteristics of the tissue structures of the preparations were compared with the systematic review data, the literature search by the following keywords: morphoethiopathy”, “vermiform process”, “lymphoepithelial formations”, “digestive system”, “lymphoid nodule”, “Peyer’s patches”, “mucous membrane”. Results: Pathogenesis of acute appendicitis – it is a consistent, staged process that is completely subject to the laws of exudative inflammation in response to microbial aggression. Removal of the appendicular process should be approached carefully and based on possible immunological consequences. Removal of the appendix as an immunocompetent organ Unreasonable removal of pathohistological unchanged appendix has medical consequences (can lead to consequences such as colon cancer) and not only. Conclusions: Our results suggest that the vermiform appendix retains its active function throughout human life. The study provides an overview with current knowledge about the etiology, pathogenesis and possible consequences of appendectomy as the main method of treatment of acute appendicitis. The search for ways to prevent appendicitis can be successful only by finding out the causes and factors that in some individuals cause the inability of the appendix to resist bacterial invasion. Appendix is necessary to fully support the immune responses of the digestive tract, but it belongs to the category of those organs, the loss of which during forced surgery does not cause significant damage to the body.

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Razvan, Popescu, Nicoleta Leopa, Iorga Ionut, Antonela-Anca Nicolau e Ghioldis Andrei. "Multivisceral Resection of Advanced Sigmoid Colon Cancer". ARS Medica Tomitana 26, n. 2 (1 maggio 2020): 95–99. http://dx.doi.org/10.2478/arsm-2020-0019.

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Abstract Introduction: Colorectal cancer is one of the most common digestive malignancies, with a high mortality and morbidity rate, with nonspecific symptoms in the early stages and with a diagnosis in the advanced stage most often. In a significant percentage there are cases in which tumors with invasion in the border organs and multiorgan resections are required. In women, the invasion frequently occurs in the vagina, uterus and bladder. Case report: We report the case of a 52-year-old woman, who presented in the Department of Surgery with the following complaints: fecaluria, pneumaturia, constipation and moderate abdominal pain, with onset of 4 months, in wich the patient neglected her symptoms. Following the investigations, a large tumor formation of sigmoid colon was diagnosed, with invasion in the uterus and bladder, with which it communicates through a 16mm fistula. The result of the biopsy was of low / moderate grade adenocarcinoma differentiated G2. Cystoscopy revealed bladder trigone invasion without being able to identify ureteral orifices, biopsy and urine cytology was also positive for cancer. The surgery was performed by a multidisciplinary team and a multivisceral resection was performed. Conclusions: Multiorgan resections require trained, experienced teams, and oncological pathology raises special issues when it comes to radical visa. The management of invasive colonic tumors in the border organs must be established preoperatively, in agreement with the patient, because it involves problems related to the quality of life and the potential for survival.

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C., Khalloufi, Ibnoulkhatib S., El Kebir A., Karkouri M., Boufettal H., Mahdaoui S. e Samouh N. "INFLAMMATORY MYOFIBROBLASTIC TUMORS IN THE PECULIAR CONTEXT OF THE POSTPARTUM CASE REPORT". International Journal of Advanced Research 9, n. 03 (31 marzo 2021): 607–11. http://dx.doi.org/10.21474/ijar01/12621.

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The debate persists about the inflammatory or tumoral, benign or malignant nature of the Inflammatory myofibroblastic tumors (TMI). Radioclinically, they can mimic a malignant neoplasm, although they are classified as intermediate by the World Health Organization (WHO). The diagnosis is almost always made by pathological examination. The treatment is poorly codified but the management is usually surgical. The removal of these tumors is a challenge when the mass is developed at the expense of or in the vicinity of noble organs. Several therapies have been tested to overcome the limitations of surgery, the results are variable. These tumors rarely affect the digestive tract. We propose the study of a case of myofibroblastic tumor developed at the expense of the omentum, five months after a cesarean section, in order to try to determine if it is a rare complication of the postpartum or a fortuitous combination.

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Furumoto, Hideyuki, Takuya Kato, Hiroaki Wakiyama, Aki Furusawa, Peter L. Choyke e Hisataka Kobayashi. "Endoscopic Applications of Near-Infrared Photoimmunotherapy (NIR-PIT) in Cancers of the Digestive and Respiratory Tracts". Biomedicines 10, n. 4 (4 aprile 2022): 846. http://dx.doi.org/10.3390/biomedicines10040846.

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Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed and promising therapy that specifically destroys target cells by irradiating antibody-photo-absorber conjugates (APCs) with NIR light. APCs bind to target molecules on the cell surface, and when exposed to NIR light, cause disruption of the cell membrane due to the ligand release reaction and dye aggregation. This leads to rapid cell swelling, blebbing, and rupture, which leads to immunogenic cell death (ICD). ICD activates host antitumor immunity, which assists in killing still viable cancer cells in the treated lesion but is also capable of producing responses in untreated lesions. In September 2020, an APC and laser system were conditionally approved for clinical use in unresectable advanced head and neck cancer in Japan, and are now routine in appropriate patients. However, most tumors have been relatively accessible in the oral cavity or neck. Endoscopes offer the opportunity to deliver light deeper within hollow organs of the body. In recent years, the application of endoscopic therapy as an alternative to surgery for the treatment of cancer has expanded, providing significant benefits to inoperable patients. In this review, we will discuss the potential applications of endoscopic NIR-PIT, especially in thoracic and gastrointestinal cancers.

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Sumathy, B., Pankaj Dadheech, Monika Jain, Ankur Saxena, S. Hemalatha, Wenqi Liu e Stephen Jeswinde Nuagah. "A Liver Damage Prediction Using Partial Differential Segmentation with Improved Convolutional Neural Network". Journal of Healthcare Engineering 2022 (27 febbraio 2022): 1–14. http://dx.doi.org/10.1155/2022/4055491.

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Background. The liver is one of the most significant and most essential organs in the human body. It is divided into two granular lobes, one on the right and one on the left, connected by a bile duct. The liver is essential in the removal of waste products from human food consumption, the creation of bile, the regulation of metabolic activities, the cleaning of the blood by sensitizing digestive management, and the storage of vitamins and minerals. To perform the classification of liver illnesses using computed tomography (CT scans), two critical phases must first be completed: liver segmentation and categorization. The most difficult challenge in categorizing liver disease is distinguishing the liver from the other organs near it. Methodology. Liver biopsy is a kind of invasive diagnostic procedure, widely regarded as the gold standard for accurately estimating the severity of liver disease. Noninvasive approaches for examining liver illnesses, such as blood serum markers and medical imaging (ultrasound, magnetic resonance MR, and CT) have also been developed. This approach uses the Partial Differential Technique (PDT) to separate the liver from the other organs and Level Set Methodology (LSM) for separating the cancer location from the surrounding tissue based on the projected pictures used as input. With the help of an Improved Convolutional Classifier, the categorization of different phases may be accomplished. Results. Several accuracies, sensitivity, and specificity measurements are produced to assess the categorization of LSM using an Improved Convolutional classifier. Approximately, 97.5% of the performance accuracy of the liver categorization is achieved with a 94.5% continuous interval (CI) of [0.6775 1.0000] and an error rate of 2.1%. The suggested method’s performance is compared to that of two existing algorithms, and the sensitivity and specificity provide an overall average of 96% and 93%, respectively, with 95% Continuous Interval of [0.7513 1.0000] and [0.7126 1.0000] for sensitivity and specificity, respectively.

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Бут-Гусаим, Г. В., А. В. Воробей e И. А. Давидовский. "Practical Anatomy of Celiac Artery and Its Collateral Circulation". Хирургия. Восточная Европа, n. 3 (6 ottobre 2022): 368–79. http://dx.doi.org/10.34883/pi.2022.11.3.017.

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Чревный ствол является одной из 3 ветвей брюшной аорты, обеспечивающих кровоснабжение органов пищеварения. Анатомия чревного ствола и его ветвей крайне вариативна, а особенности мезентериального коллатерального кровообращения позволяют компенсировать кровоток в случае его окклюзии. Учитывая вариантность анатомии, при планировании сосудистой реконструкции или резекционного хирургического вмешательства на верхнем этаже брюшной полости для обеспечения их безопасности и эффективности необходимо выполнить полноценную визуализацию сосудистой системы пищеварительного тракта. Знание анатомии позволит правильно интерпретировать полученные результаты предоперационного исследования и снизить риск ятрогенной сосудистой травмы. В настоящей статье приведены систематизированные литературные данные о практической анатомии чревного ствола и коллатеральном кровообращении его ветвей, а также клинические примеры вариантной анатомии и компенсации кровоснабжения органов при поражении чревного ствола. The celiac artery is an abdominal aortic branch providing blood supply to the digestive system. The anatomy of celiac artery and its branches is extremely variable; the features of that collateral circulation allow compensating blood flow when the trunk is occluded. Since that it is necessary to complete the comprehensive visualization of digestive tract vessels during planning of vascular reconstruction or resection surgery on the upper abdomen in order to provide its safety and efficiency. Knowledge of anatomy allows interpreting the preoperative study results in the proper way and decreasing the risk of iatrogenic vascular trauma. Systematic data on the practical anatomy of celiac artery and its branches collateral circulation is presented in this article and clinical examples of the variant anatomy and compensation of blood supply to organs when trunk is affected as well.

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Shestakov, A. L., M. E. Shakhbanov, M. V. Khrustaleva, N. A. Bulganina, I. A. Boeva, Z. E. Gadzhimusaeva e A. A. Bezaltynnykh. "Surgery of the upper departments of the digestive tract with intraoperative intra-research endoscopic assistance: review of the literature". Нospital-replacing technologies:Ambulatory surgery, n. 1-2 (8 giugno 2020): 117–24. http://dx.doi.org/10.21518/1995-1477-2020-1-2-117-124.

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This analysis is based on the study of materials from scientific electronic libraries (elibrary.ru, PubMed, scientific library of the Petrovsky National Research Centre of Surgery, Moscow, Russia). The problem of treating the pathology of the upper gastrointestinal tract is caused by the high prevalence of benign and malignant diseases of this zone, their severity, the complexity of diagnosis and often the low efficiency of conservative therapy. Intensive implementation of innovative scientific technologies in medical practice, aimed at increasing the effectiveness of treatment and diagnostic measures, minimizing their negative impact on the patient’s body and reducing the risk of complications, which, at the same time, have sufficient economic attractiveness. In full, all of the above can be attributed to endoscopy, which has been actively developing in recent years, both in the diagnostic and in the operational areas. In the treatment of various diseases of the gastrointestinal tract in recent years, combined methods based on the use of two or more minimally invasive technologies, for example, endoluminal endoscopic and thoraco or laparoscopic methods, have entered the world practice. The data of scientific articles on the problem of surgical treatment of patients with benign and malignant diseases of the upper gastrointestinal tract, carried out using intraoperative intraluminal endoscopic assistant, are analyzed. The use of intraluminal endoscopy, in particular, allows to increase the radicality of surgical interventions in patients with malignant neoplasms of the upper gastrointestinal tract, perform intraoperative topical diagnosis of non-palpable tumors, and use it in the surgical treatment of esophageal diverticulums of various localization. Also, another area of application of intraoperative intraluminal endoscopy is the assessment of tightness and anastomosis zone during surgical interventions on the organs of the gastrointestinal tract. However, this technique is in the process of implementation in clinical practice and has not been sufficiently studied both in foreign and domestic literature.

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Eveno, Clarisse, Olivier Glehen, Diane Goéré, Anne-Claire Lukaszewicz, Guillaume Passot, Dominique Elias e Marc Pocard. "Influence of bevacizumab on early postoperative complications after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal carcinomatosis of colorectal origin." Journal of Clinical Oncology 30, n. 4_suppl (1 febbraio 2012): 601. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.601.

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601 Background: Increasingly patients with IV stage colorectal cancer received systemic chemotherapy combined with targeted therapy among which bevacizumab. In neoadjuvant situation, a delay of at least 6 weeks between discontinuation of bevacizumab and surgery is recommended, not to increase the risk of complications (delayed healing, bleeding) related to bevacizumab. The goal of this study was to analyze the potential impact of bevacizumab on early morbidity after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal carcinomatosis of colorectal origin. Methods: From 2004 to 2010, in three hospitals, 183 patients treated with complete cytoreduction followed by HIPEC for colorectal carcinomatosis, received preoperative treatment. It was either systemic chemotherapy alone (Chemo group, n = 100) or by chemotherapy combined with bevacizumab (Beva group, n = 83). Results: Both patient groups were comparable in the extent of carcinomatosis, assessed on peritoneal cancer index means (10.4 vs 10, p> 0.05), number of resected organs (4.3 vs 3.8, p> 0.05), operative time (420 vs. 380 minutes, p> 0.05) and volume of blood loss (470 vs 510ml, p> 0.05). The median time from discontinuation of bevacizumab and HIPEC was 7 weeks (6-10), always greater than 6 weeks. Nine patients postoperatively died, 4 (4%) in the chemo group and 5 (6%) in the beva group (ns). Grade 3 to 5 complication rate was higher in the beva group (25 vs 12%, p <0.05). Whatever the hospital, complications that may be related to bevacizumab occurred more frequently in patients in the beva group: with more digestive fistulas (18 vs 8%, p <0.05), deep abscesses (13 vs 3 %, p <0.01) and delayed healing (11 vs 2%, p <0.02). Conclusions: Administration of bevacizumab before surgery with complete cytoreduction followed by HIPEC for carcinomatosis colorectal is associated with increased morbidity, probably due to multiple organ resections performed during the surgery. The oncologic benefit of bevacizumab before HIPEC remains to be evaluated.

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Hasanuddin, Hasanuddin, e Derevie Hendryan. "The similarity of a desmoid tumor with parasitic leiomyoma: a very rare case report and literature review". Bali Medical Journal 11, n. 1 (21 febbraio 2022): 77–80. http://dx.doi.org/10.15562/bmj.v11i1.3044.

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Introduction: Desmoid tumors are rare cases that arise from aponeurotic tissue. Parasitic leiomyoma is a rare type of leiomyoma that grows in reproductive age, but differential diagnostics have something in common.Case report: A case of a 34-year-old Asian woman, secundigravida, outpatient clinic, referred from surgery division with chief complaint of a lump in the stomach that has become bigger in the past 4 years. There was no menstrual complaint, and the patient had a history of one previous cesarean section. Computed Tomography (CT) revealed a mass on the abdominal wall that extends to the abdominal cavity, and the patient underwent a mass biopsy and the histopathology results were obtained in the form of uterine leiomyoma or fibroid. During the operation, the mass was obtained from the abdominal wall and had no connection to internal reproductive organs, and due to the large mass, we consulted to digestive surgery division for mass resection, and a mesh graft was placed. Based on the results of tissue examination, the desmoid fibromatosis tumor was obtained from histological findings.Conclusion: Preoperative management by performing magnetic resonance imaging (MRI) can be useful to evaluate the difference between both diseases. Immunohistochemistry stain should be performed to differentiate between both diseases in case the MRI unavailable.

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Hammond, K. A., M. Lam, K. C. Lloyd e J. Diamond. "Simultaneous manipulation of intestinal capacities and nutrient loads in mice". American Journal of Physiology-Gastrointestinal and Liver Physiology 271, n. 6 (1 dicembre 1996): G969—G979. http://dx.doi.org/10.1152/ajpgi.1996.271.6.g969.

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To study the relationship between capacity and load in the small intestine, we simultaneously varied dietary nutrient load and intestinal capacity in mice. Intestinal transection alone caused an increase in intestinal mass, because of increased serosal mass. Because virgin mouse intestine possesses 180% reserve uptake capacity before resection and the intestine regenerates after resection, resection of up to 50% had no effect on food intake, digestive efficiency, intestinal brush-border glucose uptake rate, or mass of all organs measured except the cecum. Regeneration of intestinal mass and glucose uptake capacity was quantitatively complete, because intestinal mass 10 wk after resection was similar to that in unresected mice. Resected intestinal mass in lactating mice was four times larger than that immediately after resection in virgin mice. Cecal mass increased in 50%-resected lactating mice with high food intakes, suggesting nutrient spillage into the distal gut as a signal for regeneration. Mice failed to survive 70% resection of the intestine, possibly because intestinal reserve uptake capacity was exhausted immediately after surgery, making regeneration impossible.

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SOUZA JÚNIOR, Erasmo Freitas de, Hécio Henrique Araújo de MORAIS, Eudes Euler de Souza LUCENA, José Rodolfo Lopes de Paiva CAVALCANTI, Fausto Pierdoná GUZEN, Dayane Pessoa de ARAÚJO e Jimmy Charles Melo BARBALHO. "State of the art in the treatment of mandibular fractures caused by firearms: case report". RGO - Revista Gaúcha de Odontologia 66, n. 1 (gennaio 2018): 88–95. http://dx.doi.org/10.1590/1981-863720180001000123387.

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ABSTRACT Injuries to the face represent a significant risk to the health of the individual, mainly because of its significance, both functional, because it houses sensory organs and part of the respiratory and digestive systems, as well as esthetic. In this scenario, gunshot wounds in this location cause great concern on account of the magnitude of the damage, and the Oral and Maxillofacial Surgery and Traumatology team must act so that the treatment enables the rehabilitation of the patient in the shortest possible time, with a minimum of complications and sequelae. The objective of this study is to report a clinical case of a 19-year-old female patient with a comminuted fracture of the mandible body caused by a firearm projectile, treated immediately with stable internal fixation using the 2.00 mm plate-screw system for simplification of the fracture and a 2.4 mm reconstruction locking-plate on the bone gap. Relevant aspects of the surgical technique and tactics are reviewed and long-term follow-up of the patient is presented.

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Milosavljevic, Vladimir, Boris Tadic, Nikola Grubor, Dragan Eric e Slavko Matic. "Laparoscopic technique as a method of choice in the treatment of non-parasitic splenic cysts". Srpski arhiv za celokupno lekarstvo 147, n. 5-6 (2019): 307–10. http://dx.doi.org/10.2298/sarh181008029m.

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Introduction/Objective. Splenic cysts are a rare clinical entity. In their origin, they may be parasitic or non-parasitic. They are classified as either primary (true) or secondary cysts (pseudocysts), depending on the presence or absence of an epithelial lining of the lumen. Methods. Using a retrospective case study, we included 29 patients undergoing laparoscopic surgery due to splenic cysts. The patients were treated within the 2007?2017 period at the Clinic for Digestive Surgery, the Clinical Center of Serbia. We analyzed pre-operative, intra-operative and post-operative characteristics of laparoscopic technique in treating non-parasitic splenic cysts. Results. The group of 29 patients treated with laparoscopic technique surgery due to the previously diagnosed splenic cyst, consisted of 12 (41.4%) men and 17 (58.6%) women. The average age of patients undergoing surgery was 38.86 ? 10.4 years (22?62). Based on the histopathological findings, there were eight epithelial cysts and 21 pseudocysts of the spleen. The maximal diameter of the splenic cyst, measured pre-operatively, was 10.09 ? 2.51 cm on average. The average operative time was 35 minutes, and the intra-operative bleeding amount was 11.48 ? 3.78 ml. None of the intra-operative complications, injury to the spleen or other organs of the abdomen, conversions to open surgery or reintervention were recorded. Conclusion. Laparoscopic fenestration with excision of the part of the spleen cyst wall (marsupialization) represents an effective and definitive treatment for this disease. It is an alternative to splenectomy, along with other well-known benefits ensured by the spleen preservation. Low probability of occurrence of intra-operative and post-operative complications, as well as minimal trauma of tissue, results in a shorter postoperative stay, rapid recovery, and better quality of life.

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Ksonz, I. V., Ie M. Grytsenko, M. I. Grystenko, O. V. Ovchar e Y. V. Pylypiuk. "Intestinal obstruction caused by Meckel’s diverticulum in children". Paediatric Surgery. Ukraine, n. 2(71) (25 giugno 2021): 72–76. http://dx.doi.org/10.15574/ps.2021.71.72.

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Meckel’s diverticulum is the most common variant of anomalies of incomplete obliteration of the yolk duct. Among the various malformations of the digestive tract, which can cause intestinal obstruction, Meckel’s diverticulum ranks first and is 1.7%. Purpose – to generalize the results of treatment of children with intestinal obstruction caused by Meckel’s diverticulum. Materials and methods. The experience of treating 183 children with Meckel’s diverticulum and related pathology is summarized. The main complications of Meckel’s diverticulum were intestinal obstruction, bleeding from a peptic ulcer, diverticulitis. In 100 children, the diverticulum was asymptomatic and was an accidental finding during surgery on the abdominal organs for other pathologies. Results. Intestinal obstruction caused by Meckel’s diverticulum accounted for 20.8% of all cases and 45.7% of all diverticulum-related complications. Strangulative intestinal obstruction was diagnosed in 18 patients: in 16 Meckel’s diverticulum caused internal compression, in 1 – torsion of the loops of the small intestine around the fixed diverticulum, in 1 – nodulation. In 5 observations, Meckel’s diverticulum caused the phenomenon of partial intestinal obstruction. Intussusception was detected in 15 children (small intestinal in 6 cases and ileocecal in 9). Clinical cases demonstrating the difficulties in diagnosing intesti nal intussusception caused by Meckel’s diverticulum in older children and small bowel entrapment in the mesodiverticular ligament are presented. A method of subserous diverticulectomy and one-step decompression of the small intestine was proposed. Conclusions. Meckel’s diverticulum should be considered as a probable cause of acute intestinal obstruction in children older than 2 years and who have not previously undergone surgery on the abdominal organs. In the surgical treatment of pathology caused by Meckel’s diverticulum, it is possible to use one-time decompression of the small intestine by diverticulotomy and subserous removal of the diverticulum. The research was carried out in accordance with the principles of the Helsinki declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: Meckel’s diverticulum, intestinal obstruction, children.

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Babii, O. M., S. A. Tarabarov, N. V. Prolom, B. F. Shevchenko e A. A. Galinsky. "ТREATMENT OF STENOSIS OF THE PYLORIC BULBAR ZONE OF ULCERATIVE GENESIS USING MINIMALLY INVASIVE SURGERY". Kharkiv Surgical School, n. 2 (20 aprile 2020): 167–75. http://dx.doi.org/10.37699/2308-7005.2.2020.33.

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Summary. Purpose: to improve the results of surgical treatment of stenosis of the pyloroduodenal zone of ulcerative origin through the use of minimally invasive laparoendoscopic interventions. Material and methods. In the Department of Surgery of the Digestive Organs of the State Institution “Institute of Gastroenterology of the NAMS of Ukraine” for 2014-2019, 114 patients with stenosis of the pyloroduodenal zone of ulcerative origin were examined. Of these, 35 — with compensated stenosis, 57 — with subcompensated, 22 — with decompensated stenosis. The average age (45.3±5.2) years. The control group consisted of 20 healthy individuals. All patients underwent surgical treatment using minimally invasive and traditional surgical interventions. Results and discussion. During the study, known indications were clarified and new indications for performing endoscopic balloon pyloroduodenoplasty and combined laparoendoscopic intervention were clarified. Complications in the immediate postoperative period occurred in 1 patient (1.04%) in the form of perforation of the dilated zone. In patients after the traditional laparotomy surgery, the average postoperative period was (15 ± 2) days. Complications in the immediate postoperative period occurred in 2 patients (11.1 %) in the form of bleeding and leaks in the pyloroplasty zone, which required repeated surgical treatment. Тhere were no fatal cases. The remote observation period was 7-22 months. Endoscopic, radiological and clinical signs of recurrence of peptic ulcer and stenosis were not detected. Conclusions. The method of minimally invasive endoscopic and combined laparoendoscopic interventions in the treatment of stenosis of the pyloroduodenal zone of ulcerative genesis is characterized by a minimal number of complications, has good efficacy indicators and the absence of disease recurrence in the long-term period.

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SAVCHENKO, Y. P., V. M. BENSMAN, I. V. SUZDAL'CEV, G. K. KARIPIDI, V. A. GOLBRAIH, B. M. BELIK, N. J. KALININA e M. I. DENISOVA. "POSTCHOLECYSTECTOMY SYNDROME CAUSED BY VARIOUS DISORDERS OF INTESTINAL PERMEABILITY". Kuban Scientific Medical Bulletin 25, n. 4 (3 ottobre 2018): 79–84. http://dx.doi.org/10.25207/1608-6228-2018-25-4-79-84.

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Aim.This study was designed to prove the connection between postcholecystectomy syndrome, chronic disorder of duodenal patency, adhesive disease of the abdominal cavity, and chronic colostasis and to develop the methods of its treatment.Materials and methods.During the period from 2004 to 2016 we monitored 140 patients with a clear picture of postcholecystectomy syndrome which was manifested after the surgeries on the extrahepatic biliary tract by clinic of passage disorders in the digestive tract.Results.The results of our study indicate that there are created a number of conditions that cause various pathologies in patients with colostasis who have unfavorable outcomes after cholecystectomy. Colostasis can cause functional changes in the biliary tract due to the overstretch of the colon areas by the accumulated contents. Functional disturbances can be a consequence of the tension of the mesocolon lowered by the transverse colon or duodenojejunal ligament narrowing the lumen of the duodenum. The hepatic angle of the large intestine in high position, deforming the bile duct and duodenum, can also cause postcholecystectomy syndrome.Conclusion. Long-term results of the surgical treatment of the pathological conditions after cholecystectomy depend not only on the condition of the organ which surgery was performed on but also on other physiologically related organs and body systems. The biliary and enteroenteric connections are very important in this case. Psychosomatic disorders of the patient are also crucial while assessing the long-term results of the surgical treatment of this type of patients. The results of the surgical treatment of the duodenal patency chronic disorders depend on the selected type of surgery. Thus, the exclusion of the duodenum from the food passage gives better results than the surgeries aimed at improving the passage of food through the duodenum. The choledochojejunostomy and duodenoenterostomy are not effective. In the most severe cases of duodenal patency chronic disorders two sided exclusion of the duodenum with duodenenterostomy can be the only effective method of its correction but the development of post-resection syndrome cannot be ruled out.

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Kostovski, Ognen, Svetozar Antovic, Gjorgji Trajkovski, Irena Kostovska, Rubens Jovanovic e Nikola Jankulovski. "High expression of CD133 - stem cell marker for prediction of clinically aggressive type of colorectal cancer". Polish Journal of Surgery 92, n. 3 (14 aprile 2020): 1–5. http://dx.doi.org/10.5604/01.3001.0014.0999.

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Background: Colorectal cancer (CRC) is one of the most common malignancies in the world. The cancer stem cell (CSC) markers are associated with aggressive cancer types and poor prognosis. The objective of study was to evaluate the CD133 expression and to correlate it with clinicopathological futures in patients with CRC. Material and Methods: Our study included ninety patients with CRC who underwent curative surgical resection from 2012 to 2017 at the University Clinic for Digestive Surgery, Skopje, North Macedonia. Tumor samples first were analyzed with standard histopathological methods and than CD133 expression was investigated immunohistochemically. The level of expression of CD133 was classified semiquantitatively. Low positivity was defined as positive immunoreactivity in < 50% of tumor glands, and high positivity was defined as positive immunoreactivity in ≥ 50% of tumor glands. Furthermore, clinicopathological futures of patients was retrospective reviewed. Results: High expression of CD133 was found in 47, 8% of patients CRC samples. In 69, 6% of patients with metastatic lesions in visceral organs we found high expression of CD133. We found statistically significant differences in expression of CD133 between patients with and without visceral metastatic lesions (p = 0, 0153), between patients with different T category ((p=0,0119), N-status (p=0,0066) and G-differentiation (p=0,0115). Our results showed that the stage of disease has the greatest impact on expression of CD133 (p <0.00001). Conclusion: High expression of CD133 is useful marker for prediction of clinically aggressive type of CRC and can be routinely implemented in standard pathohistological diagnostics.

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Grechanyk, O. I., O. S. Gerasimenko, R. Ya Abdullayev, I. A. Lurin, K. V. Humeniuk, V. V. Negoduyko, D. O. Slesarenko, N. B. Alekseeva e M. S. Sudmak. "CLINICAL AND DIAGNOSTIC ASPECTS OF FIRE I NFLAMMATION INJURIES OF HOLLOW ABDOMINAL ORGANS (ATO / OOS EXPERIENCE)". Kharkiv Surgical School, n. 1 (20 febbraio 2022): 71–81. http://dx.doi.org/10.37699/2308-7005.1.2022.13.

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Among the features of radiological diagnosis for the wounded with injuries of the gastrointestinal tract, we can point to a set of radiological methods of research, among which the leading place is occupied by X-ray contrast studies of the abdomen — vulnerography, fistulography, enterography, irigoscopy. The most important task of special methods of X-ray examination of gastrointestinal injuries, accompanied by the introduction of X-ray contrast agents, is the control of the postoperative period, radiological support during surgery and diagnosis of failure of sutures, anastomoses, intraperitoneal walls fistula, phlegmon of retroperitoneal tissue. Materials and methods. The results of retrospective analysis of radiological diagnostics of 76 (7.5 ± 1.6) % of wounded in the abdomen, waist, retroperitoneal space from the total mass of subjects (n = 1013 people), due to the mechanical and multifactorial nature of the lesion. Of these, 42 subjects with a predominant abdominal component of gastric injury injuries were in 6 cases out of 42 (14.3 %), 3 (7.1 %) cases of esophageal and duodenal injuries, small bowel injuries were observed in 12 cases (28, 6 %), colon damage in 14 cases (33.4 %) and rectal damage in 4 cases (9.5 %). All X-ray contrast studies of different parts of the digestive tract were performed with one-time double contrast and other methods in the X-ray diagnostic department of the clinic (radiation diagnostics and therapy) of the National Military Medical Clinical Center «GVKG» on modern X-ray machine expert class OPERA SWING. Discussion of results. There are no fundamental differences in the tactics of radiation control of injuries (TCU) of the gastrointestinal tract in abdominal injuries. However, in the preoperative period of urgent radiological diagnosis of damage to the esophagus, stomach, small, colon, and other parts of the colon, preference is given to non-contrast radiological examination of the abdomen (review radiography in direct projection standing / lying, lateroposition and lateral projection). In the future, the postoperative period of the wounded is accompanied by the widespread use of X-ray contrast studies of internal organs with gastrointestinal damage for radiation support during surgery and diagnosis of complications in the early and late postoperative periods. Conclusions. Given the multiple and combined nature of gunshot and non-gunshot injuries to the abdomen, lower back, retroperitoneal space in the wounded with injuries of the esophagus, stomach, small, colon and other parts of the colon, immediate radiological diagnosis should be provided to all wounded. preoperative period to address the clinical and diagnostic problem of emergencies. Since the natural X-ray contrast of the abdominal cavity and retroperitoneal space is very low, and damaged hollow organs increase pneumatization of the gastrointestinal tract, the use of artificial contrast (barium mixture, iodine-containing water-soluble X-ray contrast agents) significantly increases the diagnostic value. The use of special methods of X-ray examination with artificial contrast in the postoperative period is determined by the condition of the wounded and the specific clinical situation.

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Kreshchenko, Grebenshchikova e Karpov. "INFLUENCE OF SEROTONIN ON PLANARIAN PHOTORECEPTORS’ REGENERATION". THEORY AND PRACTICE OF PARASITIC DISEASE CONTROL, n. 20 (14 maggio 2019): 278–83. http://dx.doi.org/10.31016/978-5-9902340-8-6.2019.20.278-283.

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The paper presents data on the effect of biogenic amine, serotonin, on morphogenetic processes in planarians Schmidtea mediterranea and Girardia tigrina(Turbellaria, Platyhelminthes). For the study, cut-off median and tail fragments of the planarian body were used, in which eye regeneration was observed. Photoreceptor recovery occurred from the 3rd to the 6th day of regeneration. In experimental specimens exposed to serotonin at a concentration of 0.1–1 μM, acceleration of the photoreceptor regeneration process was observed. The stimulating effect was observed at 4–5 days after surgery. Planaria (Turbellaria, Platyhelminthes) are free-living flatworms related to parasitic trematodes, cestodes and monogenges. In addition to the nervous, muscular, digestive, excretory and reproductive systems, they have a pair of simple eyes (photoreceptors), so they can distinguish the intensity and direction of the light flux and are oriented in space [1]. Planarium eyes are located on the dorsal surface of the head part of the body and consist of photoreceptor and pigment cells that form an "eye cup". Planaria can regenerate the whole organism from a small fragment. In the process of regeneration, the planarium can completely restore the head ganglion (brain), as well as other organs, including the eyes.Our task was to study the dynamics of photoreceptor differentiation in planarians Schmidtea mediterranea, and to investigate the possible morphogenetic function of serotonin in S. mediterranea and G. tigrina

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Tessier, Romain, Lara Ribeiro-Parenti, Ouafa Bruneau, Nadezda Khodorova, Jean-Baptiste Cavin, André Bado, Dalila Azzout-Marniche, Juliane Calvez, Maude Le Gall e Claire Gaudichon. "Effect of different bariatric surgeries on dietary protein bioavailability in rats". American Journal of Physiology-Gastrointestinal and Liver Physiology 317, n. 5 (1 novembre 2019): G592—G601. http://dx.doi.org/10.1152/ajpgi.00142.2019.

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Bariatric surgery may induce protein malabsorption, although data are scarce. This study aims at evaluating dietary protein bioavailability after different bariatric surgeries in rats. Diet-induced obese Wistar rats were operated for vertical sleeve gastrectomy (VSG) or Roux-en-Y gastric bypass (RYGB). The control group was composed of pair-fed, sham-operated rats (Sham). Two weeks after surgery, rats were fed a 15N protein meal. Protein bioavailability was assessed by determination of 15N recovery in the gastrointestinal tract and organs 6 h after the meal. Fractional protein synthesis rate (FSR) was assessed using a flooding dose of 13C valine. Weight loss was the highest in RYGB rats and the lowest in Sham rats. Surprisingly, RYGB (95.6 ± 0.7%) improved protein digestibility ( P = 0.045) compared with Sham (93.5 ± 0.5%) and VSG (93.8 ± 0.6%). In contrast, 15N retained in the liver ( P = 0.001) and plasma protein ( P = 0.037) was lower than in Sham, with a similar trend in muscle ( P = 0.052). FSR was little altered by bariatric surgery, except for a decrease in the kidney of RYGB ( P = 0.02). The 15N distribution along the small intestinal tissue suggests that dietary nitrogen was considerably retained in the remodeled mucosa of RYGB compared with Sham. This study revealed that in contrast to VSG, RYGB slightly improved protein digestibility but altered peripheral protein bioavailability. This effect may be ascribed to a higher uptake of dietary amino acids by the remodeled intestine. NEW & NOTEWORTHY Using a sensitive 15N meal test, we found that gastric bypass slightly improved protein digestibility compared with sleeve gastrectomy or control but, in contrast, lowered protein retention in the liver and muscles. This paradox can be due to a higher uptake of dietary nitrogen by the intestinal mucosa that was hypertrophied. This study provides new insight on the digestive and metabolic fate of dietary protein in different models of bariatric surgery in rats.

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Matsui, Yuuki, Sena Iguchi, Emiri Sato, Yoichiro Sato, Ken Shindo, Michiko Ishida, Yutaka Saito et al. "Atypical Gunshot Injury Traversing the Neck with an Unexpected Nonlinear Bullet Trajectory: a Case Report and Review of the Literature". SN Comprehensive Clinical Medicine 3, n. 2 (29 gennaio 2021): 765–71. http://dx.doi.org/10.1007/s42399-021-00760-3.

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AbstractGunshot injuries involving the head and neck region yield profound morbidity and mortality rates. Projectile-related factors comprising various physical and dynamic properties of a bullet, as well as tissue-related factors, determine the disruptive effects of projectiles on living tissues. We experienced an extremely unusual case of a gunshot injury to the neck, wherein the bullet transversely penetrated across the deep neck structures to the contralateral side of the shoulder without damaging any vital organs. A 51-year-old man presented with a gunshot wound to the neck from a point-blank range. A bullet entry hole was observed on the left side of the neck without an exit hole; however, the patient was conscious, vital signs were normal, and no active bleeding, cranial nerve palsy, or aero-digestive tract injury was found. Imaging tests revealed a bullet lying in front of the right humeral head, which was extracted by emergency surgery. The patient was uneventfully discharged. According to the localization of the damaged tissues and the positional relationship between the bullet’s entrance and its destination, the bullet was estimated to have nonlinearly traversed the neck by traveling through the interstructural spaces associated with the least tissue resistance. Our experience strongly suggests the importance of realizing the unpredictable nature of a bullet trajectory in a body. An appropriate understanding of various ballistic factors and wounding mechanisms can be of great help in the adequate assessment and management of patients with gunshot injuries.

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Dronova, V. L., O. I. Dronov, O. M. Mokrik, P. P. Bakunets e Yu P. Bakunets. "Clinical case of sharp bowel obstruction during pregnancy for a patient with an extracorporal impregnation and large intergenic interval". UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS, n. 3(87) (29 settembre 2021): 77–82. http://dx.doi.org/10.15574/pp.2021.87.77.

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The great importance in the development of acute intestinal obstruction (AIO) is the change in intestinal kinetics during pregnancy. In pregnant women, the rhythmic function of the intestine slows down due to an increase in the threshold of excitability of its receptors to biologically active substances. The article provides an overview of modern literary sources on the problem of acute intestinal obstruction in pregnant women. According to foreign literature sources, the incidence of intestinal obstruction in pregnant women is 1:3600–1:66000, and complications of diseases of the digestive system rank 4th among the causes of maternal mortality during pregnancy — 9%. According to domestic scientific sources, the frequency with which intestinal obstruction occurs in pregnant women is 1:40000–1:50000 births, mortality reaches 35–50%, stillbirth — 60–75%. The development of the disease is caused by physiological changes in the body of a pregnant woman. With increasing gestational age there are changes in the anatomical arrangement of the abdominal organs. From the second trimester of pregnancy, the uterus extends beyond the pelvis and gradually occupies the entire abdominal cavity. The increase in the size of the uterus due to hypertrophy and hyperplasia of muscle fibers, amniotic fluid, fetal growth, leads to increased intraabdominal pressure, displacement of the small intestine and lumbar colon up, thereby creating conditions for compression of intestinal loops, nodules, development. The modern classification, clinic, diagnostics and methods of treatment of this surgical pathology are presented. The author presents his own clinical case of acute intestinal obstruction in a 51-year-old pregnant woman with the sixth desired pregnancy, which occurred as a result of assisted reproductive technologies and a large intergenetic interval. Both surgeon and obstetrician-gynecologist treat intestinal obstruction in pregnant women. Conservative treatment is carried out simultaneously with diagnostic procedures. No effect of conservative therapy for 2 hours is an indication for surgery. The main purpose of surgery is to eliminate the causes of intestinal obstruction and restore bowel function. The scope of surgery is determined in each case individually and depends on the type of AIO and the age of the disease. The chosen tactics of the preoperative period, the volume of surgery, anesthesia and adequate management of the postoperative period can cure acute surgical pathology, maintain the desired pregnancy, avoid the development of obstetric and surgical purulent-septic complications. The research was carried out in accordance with the principles of the Helsinki declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: sharp bowel obstruction, pregnancy, extracorporal impregnation, large intergenic interval.

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Nikiema, S., D. Massimbo, H. Bouhdadi, H. Wazaren, M. Boumaaz e J. Rhissassi. "Management of Acute Aortic Dissection Associated With Malperfusion Syndrome: About 4 Cases and Review of the Literature". SAS Journal of Surgery 7, n. 10 (5 ottobre 2021): 536–41. http://dx.doi.org/10.36347/sasjs.2021.v07i10.003.

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Background: Acute aortic dissection is a medico-surgical emergency that is associated with a poor prognosis, especially when complicated by malperfusion syndrome. Purpose: The objective of our study was to assess the prognosis and management of aortic dissection complicated by malperfusion syndrome. Methods: Retrospective study from December 2017 to October 2019 including 4 patients hospitalized for aortic dissection with malperfusion syndrome operated at the Ibn Sina University Hospital. The diagnosis was made on clinical, biological and CT scans. Results: Patients’ mean age was 65.75 ±11,5 years with a sex ratio M / F of 1/3. Hypertension was the main risk factor and was found in all patients, only one of our patients was a smoker. The organs affected by malperfusion are divided as follows: Two (02) cases of lower limb malperfusion, two (02) cases of digestive malperfusion, one case of renal malperfusion, one case of cerebral malperfusion and one case of myocardial malperfusion. The management was surgical. Three patients underwent supracoronary tube placement and one patient underwent Bentall's procedure. Aorto-coronary bypass, an axillofemoral bypass and a cross bypass were performed to remove myocardial and lower limbs malperfusions. Mortality at one month was 50%, with one patient dying in-hospital from cardiogenic shock and one patient dying at one month from lower limb gangrene. Conclusion: Surgery is still relevant in managing aortic dissection associated with malperfusion. In our study, the survival at one month was 50%, suggesting the necessity to improving our management of aortic dissection when associated with malperfusion.

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Parvez, MA, MR Faruque, BC Sutradhar, MM Rahman, A. Mannan e R. Khatun. "Clinical Diseases and Manifestations of Goats and Cattle Recorded at Teaching Veterinary Hospital in Chittagong Veterinary and Animal Sciences University". Bangladesh Journal of Veterinary Medicine 12, n. 1 (16 settembre 2014): 73–81. http://dx.doi.org/10.3329/bjvm.v12i1.20467.

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Teaching Veterinary Hospital (TVH) in Chittagong Veterinary and Animal Sciences University (CVASU) plays an important role of public service to animal welfare since the period of 1996. There are lots of goats and cattle are recorded in this hospital every year but previously no report published on it. So this research was conducted to determine the prevalence of clinical diseases and manifestations of goats and cattle recorded at TVH in CVASU during the period of January to December 2012. A total of 3090 clinical cases (goats 2778 and cattle 312) were registered. Diagnosis of these clinical diseases and disorders were based on clinical history, clinical sign and different lab test. Medicinal cases constituted highest percentage (goats 74.66% and cattle 66.35%) in comparison to surgical (goats 16.84% and cattle 24.04 %) cases and gynae-obstetrical (goats 8.50% and cattle 9.62%) cases. Among the (1) medicinal cases, highest percentage was recorded with the diseases of digestive system (goats 16.85% and cattle 20.83%) followed by parasitic diseases (goats 15.22% and cattle 12.82%), infectious diseases (goats 11.95% and cattle 12.18%), general systemic states (goats 7.91% and cattle 6.73%), disease of the respiratory system (goats 9.57% and cattle 4.16%), urinary system(goats 3.31% and cattle 1.28%), special sense organs (goats 3.99% and cattle 1.28%) and noninfectious diseases (goats 5.83% and cattle 4.17%). Among of the (2) surgical cases, general surgery (goats 11.77 and cattle 16.58%) was higher in percentage than special (goats 3.31% and cattle 3.20%) and orthopedic (goats 1.76% and cattle 3.85%) surgery. Among of the gynae-obstetrical cases, gynaecological disorders were recorded higher (goats 6.98% and cattle 8.33%) than obstetrical disorders (goats 1.51% and cattle 1.28%). Prevalence of clinical diseases and disorders were analyzed on the basis of age, sex, breed and season. P-value (P?0.05) was considered as significant. So that an appropriate control strategy has to be designed and applied, which helps to prevent of these disease conditions in study area.DOI: http://dx.doi.org/10.3329/bjvm.v12i1.20467 Bangl. J. Vet. Med. (2014). 12 (1): 73-81

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