Bibliografie tematiche / Diabetes in children

Letteratura scientifica selezionata sul tema "Diabetes in children"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 31 luglio 2024

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Articoli di riviste sul tema "Diabetes in children"

Woznicová, Kateřina, Jiří Strnadel, Štěpánka Průhová, Jan Pavlíček e Michal Hladík. "Glucokinase diabetes in children". Česko-slovenská pediatrie 77, n. 2 (15 marzo 2022): 86–90. http://dx.doi.org/10.55095/cspediatrie2022/012.

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Balik, B. "Children with Diabetes". Nurse Practitioner 12, n. 10 (ottobre 1987): 42. http://dx.doi.org/10.1097/00006205-198710000-00007.

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Scott, C. R., J. M. Smith e M. M. Cradock. "Children with Diabetes". Nurse Practitioner 22, n. 10 (ottobre 1997): 128. http://dx.doi.org/10.1097/00006205-199710000-00039.

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Saravanan, Santhana L., e Rabin Mohanty. "Diabetes in Children". InnovAiT: Education and inspiration for general practice 5, n. 2 (21 novembre 2011): 83–93. http://dx.doi.org/10.1093/innovait/inr172.

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Hirst, Martin. "Children with diabetes". 5 to 7 Educator 2008, n. 48 (dicembre 2008): 32–33. http://dx.doi.org/10.12968/ftse.2008.7.12.31586.

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Denton, Jane. "Diabetes in children". Nursing 27, n. 1 (gennaio 1997): 6. http://dx.doi.org/10.1097/00152193-199701000-00003.

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Yeager, Terri. "Diabetes in children". Journal of Home Health Care Practice 4, n. 3 (agosto 1992): 46–51. http://dx.doi.org/10.1177/108482239200400308.

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Baum, J. D. "Children with diabetes." BMJ 301, n. 6751 (15 settembre 1990): 502–3. http://dx.doi.org/10.1136/bmj.301.6751.502.

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Gorelov, A. V., A. A. Nijevitch, V. G. Alyangin, O. A. Malievskiy, G. M. Yakupova, V. A. Malievskiy e A. A. Arslanov. "Diabetic enteropathy in children". Voprosy praktičeskoj pediatrii 17, n. 1 (2022): 196–98. http://dx.doi.org/10.20953/1817-7646-2022-1-196-198.

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The type 1 diabetes mellitus (T1DM) represents one of the most common diseases in childhood. Diabetes is linked to gastrointestinal complications (GI) such as intestinal enteropathy. The aim of this study was to characterize the duodenal histology in pediatric patients with T1DM in comparison to those without. Patients and methods. We enrolled 108 pediatric patients with T1DM (47 boys, 61 girls, mean age 13.1 ± 1.9 years) who were referred to the GI unit with duodenal biopsies collection (Children’s Republican Hospital, Ufa, Russia). Out of all children with T1DM, 74 (68.5%) showed histological signs of duodenal inflammation. In the comparison non-T1DM group, 21 patients (67.7%) showed inflammatory changes in duodenal mucosa. Histological evidence of chronic duodenitis was revealed significantly higher (p < 0.001) in group 2 of T1DM children (47/51) than in group 1 of T1DM (27/57). Celiac disease (CD) related duodenal lesions were found in 10 of T1DM patients (9.2%) and all confirmed by the serology. None of the comparison group children demonstrated CD signs on histology. Conclusion. The results of the present study demonstrated that chronic duodenitis is frequently present in patients with T1DM, but chronic duodenal inflammation is not always a consequence of CD or infection presence. Key words: children, diabetes mellitus, enteropathy, inflammation

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Kalra, Sanjay, KM Prasanna Kumar e P. Raghupathy. "Diabetes-friendly environments for children with diabetes". Indian Journal of Endocrinology and Metabolism 19, n. 7 (2015): 1. http://dx.doi.org/10.4103/2230-8210.155324.

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Tesi sul tema "Diabetes in children"

Caracciolo, Dana Andriana. "Children's Literature and Diabetes". Thesis, Virginia Tech, 2007. http://hdl.handle.net/10919/31824.

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My studies consider the genre of children's literature, specifically picture books, and their treatment of the topic of diabetes. I frame my argument with an examination of diabetes, the psychological effects of diabetes on the child, the need of thorough education about diabetes. I argue for the use of the picture book as an effect tool in educating and socializing the diabetic child. I first explore the implications of diabetes and the long term complications caused by one's poor control of the disease. I then explore the psychological ramifications of a chronic illness on the young child. Next I assert the need to combine the physiological and psychological factors of diabetes into a responsible text for children, one which both serves as an educating tool and a source of comfort in difficult times with the disease. I conclude my studies with critiques of existing materials in the limited genre and compare them to the story I have written for children about diabetes.
Master of Arts

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Dawkins, Melissa K. "Impact of children's diagnosis of diabetes on mothers and children /". Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09SPS/09spsd271.pdf.

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McKnight, Sarah. "Diabetes Camp". ScholarWorks@UNO, 2008. http://scholarworks.uno.edu/td/708.

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Every summer Camp Hopewell in Oxford, Mississippi hosts its annual summer camps. Over the course of a week, kids between the ages of seven and fifteen run, play, hike, and canoe. It's the pretty standard summer camp fair, but there is something that makes a week at Camp Hopewell different. Every child that comes to camp has been diagnosed with Type I Diabetes. Some have had it for years and consider camp their second home while some have just been diagnosed and still live in fear of their condition. For this one week, however, they all have something in common, and while they eat, sleep, and play, they learn to take care of their own Diabetes. Diabetes Camp is a 25 minute documentary film that is meant to show audiences the remarkable occurrences at Camp Hopewell through the eyes and voices of the campers and the staff that work there.

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Bu-Maryoum, Nayef Y. "Diabetes awareness among children : a comparison study of diabetes knowledge in school-age children between U.S. and Kuwait /". View online, 2006. http://repository.eiu.edu/theses/docs/32211131326320.pdf.

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Skoglund, Camilla. "Autoantibodies related to type 1 diabetes in children". Doctoral thesis, Linköpings universitet, Pediatrik, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-64593.

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Type 1 diabetes is an autoimmune disease resulting from destruction of the insulin producing beta cells in the pancreas. The patients need life-long heavy treatment and still complications, both acute and later in life, are common. The incidence of type 1 diabetes has increased rapidly during the last decades, especially among young children. The disease can be predicted by genes predisposing type 1 diabetes, mainly human leukocyte antigen (HLA) genes, together with presence of autoantibodies to beta-cell antigens, where multiple autoantibodies confer the highest risk. A number of immune system intervention trials are now ongoing aiming to halt the progression of the inflammatory process in the beta cells. This thesis aimed to investigate the prevalence and levels of autoantibodies in healthy children and in children with type 1 diabetes. Another aim was to study different properties of one of these autoantibodies, such as to which epitopes the antibodies bind and the distribution of immunoglobulin (Ig)-G subclasses, after immunomodulatory treatment in children with type 1 diabetes. We found that positivity to autoantibodies against glutamic acid decarboxylase (GADA) and tyrosine phosphatase like protein islet antigen-2 (IA-2A) was associated with HLA risk genotypes in 5-year old children from the general population. HLA risk genotypes seemed important for persistence of autoantibodies and for development of type 1 diabetes, while emergence of autoantibodies, especially transient autoantibodies, seemed to be more influenced by environmental factors. Improved methods for detection of autoantibodies are needed, for prediction of diabetes and for identification of high-risk individuals suitable for prevention treatments. Therefore, an assay for measurement of insulin autoantibodies (IAA), based on surface plasmon resonance (SPR), was developed. The main advantages of this method are that there is no need for labelling and that it is time-saving compared to the traditionally used radioimmunoassay (RIA), but further development of the method is needed. Treatment with GAD-alum (Diamyd) in children with type 1 diabetes has shown to preserve residual insulin secretion. This clinical effect was accompanied by an increase in GADA levels. We investigated the epitope reactivity of GADA in both GAD-alum and placebo treated children, and found that binding to one of the tested epitopes was temporarily increased after injection of GAD-alum. This result suggests that the quality of GADA was, to some extent, transiently affected by the treatment. On the other hand, no changes in binding to epitopes associated with stiff person syndrome (SPS) were observed, which together with the lack of change in GAD65 enzyme activity further strengthens the safety of the treatment. We also observed that the distribution of IgG subclasses was changed by GAD-alum treatment, with a lower proportion of IgG1 and higher IgG3 and IgG4. Lower IgG1 and higher IgG4 suggest a temporary switch towards a protective Th2 immune response, which has previously been observed in the same individuals for other immunological markers. In conclusion, measurement of autoantibodies related to type 1 diabetes is an important tool for studying the autoimmune process in pre-diabetic and type 1 diabetic children. In addition to the use as markers of disease progression, the autoantibodies may be used for studying the effects of immunomodulatory treatments on the humoral immune response.

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Moyer, Agnes Alwyn. "The specialist nursing care of children with diabetes". Thesis, King's College London (University of London), 1993. https://kclpure.kcl.ac.uk/portal/en/theses/the-specialist-nursing-care-of-children-with-diabetes(22929284-947a-4706-9cc2-a9128e7623d1).html.

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Northam, Emma J. K. "The epidemiology of diabetes in very young children". Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284899.

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Chiasera, Janelle Marie. "Examination of the determinants of overweight and diabetes mellitus in U.S. children". Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1118948445.

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Thesis (Ph.D.)--Ohio State University, 2005.
Title from first page of PDF file. Document formatted into pages; contains xvi, 144 p.; also includes graphics. Includes bibliographical references (p. 130-144). Available online via OhioLINK's ETD Center

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Ismail, Ahmad Faisal Bin. "Oral health status in children with type I diabetes mellitus". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206501.

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Diabetes mellitus is a metabolic disorder with varied etiology and diverse clinical course. World Health Organization (WHO) has distinguished three types of diabetes mellitus: insulin-dependent (Type I), non insulin-dependent (Type II) and associated with other disease and syndromes. Type I diabetes patients account for approximately 10% of all diabetics, in which children and adolescent almost exclusively develop Type I diabetes. Diabetes can be diagnosed on the basis of symptoms, such as excessive thirst appetite, polyuria, body weight reduction, glucosuria and hyperglycaemia, confirmed by laboratory test. Acute complications may develop in the course of diabetes, usually related to extreme level of plasma glucose. Chronic complications usually developed secondary to micro-vascular changes, causing damages to small vessels, nerves, multiple organs and oral cavity. The systematic review summarized the available evidence on the oral health of children with Type I diabetes mellitus. A total of 1179 abstract were retrieved during the initial search, and after exclusion, only 37 articles were qualified for final review and analysis. Though there was conflicting evidence regarding caries experience, it is clear that children with Type I diabetes mellitus exhibited poorer overall oral health status with higher plaque accumulation compared to healthy children. The case-control study aimed to evaluate and compare the oral health status of children with Type I diabetes mellitus with healthy, non-diabetic controls in Hong Kong. A sample of 64 children (32 Type I diabetes mellitus, 32 age- and gender-matched controls) were included in the study. The study concluded that children with Type I diabetes had poor oral health status with greater plaque deposition when compared to healthy, non-diabetic controls.
published_or_final_version
Dental Surgery
Master
Master of Dental Surgery

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Bulsara, Mahesh K. "Epidemiology of severe hypoglycaemia in children and adolescents with type 1 diabetes". Telethon Institute for Child Health Research, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0226.

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[Truncated abstract] Type 1 Diabetes is emerging as a significant public health problem faced by nearly every country in the world. It has major economic and social implications with considerable burden of illness. Approximately 140,000 Australians have been diagnosed with T1DM with an annual increase in incidence rate of 3% per year, comparable to the overall global increase. The management of T1DM requires insulin therapy which places considerable burden on the patient and their carers. Coping with daily insulin injections, dietary changes, modification of physical activity and vigilant monitoring of blood glucose levels, will impact on patient?s quality of life. The optimum goal for the treatment of type 1 diabetes is to safely achieve near-normal glycaemia and failure to maintain this goal accelerates the progression of the devastating long term complications of diabetes. Unfortunately attempts to achieve near normal glycaemia are limited by the risk of excessive lowering of blood glucose levels and hypoglycaemia remains a major barrier to strict glucose control of diabetes. In general this thesis focuses on two fundamental issues related to the epidemiology of severe hypoglycaemia. Namely, methodological consideration when analysing prospective observational data and application of the most robust methodology. A prospective open cohort study of the Princess Margaret Hospital diabetes clinic established in 1992, with 99% case ascertainment was used. This hospital is the only paediatric referral centre for type 1 diabetes and every child diagnosed in the state of Western Australia is treated at this centre. ... The results of this study showed that severe hypoglycaemia remains a major problem and recent approaches to therapy may be allowing a degree of improved control without the expected increased risk of severe hypoglycaemia. The study in chapter 7 investigates genetic risk factors related to severe hypoglycaemia. A significant relationship where the presence of the iv deletion (D) allele of the angiotensin-converting enzyme (ACE) increases risk of severe hypoglycaemia has been reported. This study concludes that the presence of D allele of the ACE gene does not predict a significantly higher risk of severe hypoglycaemia. In an attempt to optimize glycemic control, patients may suffer multiple episodes of severe hypoglycaemia which can adversely affect quality of life as well as educational and intellectual disadvantage. The study in chapter 8 investigates the factors related to recurrent severe hypoglycaemia. A rigorous and informative time-to-event approach is used to account for within child correlation, staggered enrolment and timevarying covariates. This allows important risk factors to change over time. Preschool children have an increased risk of experiencing recurrent severe hypoglycaemia. The findings of this thesis highlights the importance of selecting appropriate analytical methodology to identify risk factors associated with severe hypoglycaemia and also to dismiss factors that had previously been thought to be important. This will help in formulating management plans in order to limit the impact of severe hypoglycaemia.

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Libri sul tema "Diabetes in children"

Alter, Craig A., a cura di. Diabetes Insipidus in Children. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-83248-3.

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Jayakumar, R. V., Nisha Bhavani e Praveen V. Pavithran. Diabetes in children and adolescents. New Delhi: Jaypee Brothers Medical Publishers (P) LTD., 2013.

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New York (State). Dept. of Health, American Diabetes Association e Juvenile Diabetes Foundation (U.S.), a cura di. Children with diabetes: A resource guide for families of children with diabetes. [Albany]: NYS Dept. of Health, 2000.

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Tamborlane, William V., a cura di. Diabetes in Children and Adolescents. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-64133-7.

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H, Brouhard Ben, e Schreiner Barbara-Jo, a cura di. Diabetes mellitus in children and adolescents. Philadelphia: Saunders, 1987.

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Bergman, Thomas. Meeting the challenge: Children living with diabetes. Milwaukee: Gareth Stevens Publishing, 1992.

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Donaldson, Malcolm D. C., John W. Gregory, Guy Van Vliet, Joseph I. Wolfsdorf e Johnny Deladoëy. Practical Endocrinology and Diabetes in Children. Chichester, UK: John Wiley & Sons, Ltd, 2019. http://dx.doi.org/10.1002/9781119386230.

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Raine, Joseph E., Malcolm D. C. Donaldson, John W. Gregory e Guy Van Vliet. Practical Endocrinology and Diabetes in Children. Oxford, UK: Wiley-Blackwell, 2011. http://dx.doi.org/10.1002/9781444342116.

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Raine, Joseph E., Malcolm D. C. Donaldson, John W. Gregory, Martin O. Savage e Raymond L. Hintz, a cura di. Practical Endocrinology and Diabetes in Children. Malden, Massachusetts, USA: Blackwell Publishing Ltd, 2006. http://dx.doi.org/10.1002/9780470994856.

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E, Raine Joseph, a cura di. Practical endocrinology and diabetes in children. Oxford: Blackwell Science, 2001.

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Capitoli di libri sul tema "Diabetes in children"

Sivasubramanian, Ramya, e Kevin E. Meyers. "Nephrogenic Diabetes Insipidus". In Diabetes Insipidus in Children, 175–88. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-83248-3_16.

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Goldstein, Mark L., e Stephen Morewitz. "Diabetes Mellitus". In Chronic Disorders in Children and Adolescents, 217–30. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-9764-7_11.

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Alter, Craig A. "Diabetes Insipidus in Children". In 2016 Meet-The-Professor: Endocrine Case Management, 292–94. 2055 L Street, NW, Suite 600, Washington, DC 20036: The Endocrine Society, 2016. http://dx.doi.org/10.1210/mtp5.9781943550043.ch54.

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Dolan, Lawrence M. "Type 2 Diabetes in Children and Adolescents". In Pediatric Diabetes, 61–88. Boston, MA: Springer US, 2003. http://dx.doi.org/10.1007/978-1-4615-0507-5_3.

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Miranda Lora, América Liliana, Martha Beauregard Paz e Miguel Klünder Klünder. "Diabetes in Children and Adolescents". In The Diabetes Textbook, 941–66. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11815-0_60.

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Lora, América Liliana Miranda, Montserrat Espinosa Espíndola, Martha Beauregard Paz, Jorge Mario Molina Díaz e Miguel Klünder Klünder. "Diabetes in Children and Adolescents". In The Diabetes Textbook, 1063–94. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-25519-9_64.

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Cheung, Clement. "Craniopharyngioma and Diabetes Insipidus". In Diabetes Insipidus in Children, 107–19. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-83248-3_9.

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Northam, Elisabeth. "Effects of Diabetes on Neurocognitive Function of Children". In Behavioral Diabetes, 79–89. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-33286-0_7.

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Nüsken, Kai D., e Jörg Dötsch. "Diabetic Nephropathy in Children". In Diabetes and Kidney Disease, 143–52. Oxford, UK: Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781118494073.ch11.

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Colville, Susie. "Diagnostic tools for children". In Psychosocial Aspects of Diabetes, 225–33. London: CRC Press, 2021. http://dx.doi.org/10.4324/9781785230967-18.

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Atti di convegni sul tema "Diabetes in children"

Kyfonidis, Charalampos, e Marilyn Lennon. "Mummy, Why Do I Have Diabetes?" In IDC '16: Interaction Design and Children. New York, NY, USA: ACM, 2016. http://dx.doi.org/10.1145/2930674.2935979.

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Vaselić, Nada, Gordana Bukara-Radujković e Mira Spremo. "DEPRESSION OF CHILDREN WITH DIABETES". In Child and Adolescence Psychiatry and Psychology in Bosnia and Herzegovina-State and Perspectives. Akademija nauka i umjetnosti Bosne i Hercegovine, 2017. http://dx.doi.org/10.5644/pi2017.173.08.

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Shin, Ji Youn, e Bree E. Holtz. "Towards Better Transitions for Children with Diabetes". In IDC '19: Interaction Design and Children. New York, NY, USA: ACM, 2019. http://dx.doi.org/10.1145/3311927.3325319.

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Nowak-Göttl, U., W. D. Kreuz, M. John, B. Krackhardt, H.-P. Grüttner, H. K. Breddin e F. kollmann. "HAEMOSTASEOLOGICAL CHANGES IN DIABETIC CHILDREN (HUMAN INSULIN VERSUS PORCINE INSULIN". In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643099.

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Changes of haemostaseological parameters are involved in pathogenesis of diabetic angiopathy. However it is not yet clear whether they are cause or consequence of the endothelial damage. We investigated coagulation parameters in 84 children with type I diabetes mellitus without clinical signs of vascular disease.Compared to the control group no significant changes could be seen in fibrinogen, plasminogen, protein C, α 1 antichymotrypsin, β-thrombo-globulin and ristocetin - induced aggregation.Additionally we could observe significant differences in patients treated with human insulin to those treated with porcine insulin. Spontaneous platelet aggregation (PAT III) and factor VIII C correlated to the duration of diabetes. Also to the mean metabolic equilibrium (HBA1) correlations could be found. Spontaneous platelet aggregation seems to be a useful parameter to assess the onset of atherosclerotic diseases in diabetic children. High values of von Willebrand factor may indicate reversible and/or irreversible damage of vascular endothelium.

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Webster, Mary, Emma Foster, Rob Comber, Simon Bowen, Tim Cheetham e Madeline Balaam. "Understanding the lived experience of adolescents with type 1 diabetes". In IDC '15: Interaction Design and Children. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2771839.2771854.

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Harris, Andy, Arjan Durresi, Mihran Tuceryan e Tamara S. Hannon. "Integrated and Personalized Diabetes Coach for Children". In 2015 IEEE 29th International Conference on Advanced Information Networking and Applications Workshops (WAINA). IEEE, 2015. http://dx.doi.org/10.1109/waina.2015.120.

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Hatata, AH, MA Tasbihi e RO Misquith. "G435(P) Hypertension in children with diabetes". In Royal College of Paediatrics and Child Health, Abstracts of the RCPCH Conference–Online, 25 September 2020–13 November 2020. BMJ Publishing Group Ltd and Royal College of Paediatrics and Child Health, 2020. http://dx.doi.org/10.1136/archdischild-2020-rcpch.376.

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Kharbotly, Douaa. "27 Metabolic syndrome in obese children over five years old". In The 7th ASPED-ISPAD Diabetes Academy. BMJ Publishing Group Ltd, 2024. http://dx.doi.org/10.1136/bmjpo-2024-asped.27.

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-Ul-Ain, Farhat, Madis Kaaret e Vladimir Tomberg. "Enhancing Needs Discovery in Children with Type I Diabetes through Collage Techniques". In IDC '24: Interaction Design and Children. New York, NY, USA: ACM, 2024. http://dx.doi.org/10.1145/3628516.3659410.

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Hamza, Rasha T. "4 Obesity comorbidities and type 2 diabetes in children and adolescents". In The 6th ASPED-ISPAD Diabetes Academy. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/bmjpo-2023-asped.4.

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Rapporti di organizzazioni sul tema "Diabetes in children"

Vakhlova, Irina, Irina Zaikova, Alexey Kiyaev e Yulia Ibragimova. Electronic educational resource (EOR) "Module. Diabetes mellitus in children". SIB-Expertise, gennaio 2024. http://dx.doi.org/10.12731/er0781.29012024.

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Diabetes mellitus occupies a leading place in the pathology of the endocrine system in children and adolescents and remains one of the most urgent health problems in most countries. In the last decade, the annual incidence of type 1 diabetes in children has shown a significant increase both in Russia and around the world. According to the International Diabetes Federation (IDF), it is increasing by 3% per year. In addition, in all European countries there is a "phenomenon of rejuvenation of diabetes" - an increase in the proportion of children who first fell ill with type 1 diabetes at a younger age: 25-30% up to 4 years of age; up to 80% - from 6 months to 9 years. The annual incidence of type 1 diabetes in children (0-14 years old) in the Sverdlovsk region over the past decade (2006-2017) has almost doubled: from 12.2 cases per 100 thousand children in 2006 to 23 ,7 in 2017 and occupies one of the leading places in the Russian Federation in this indicator. More than 200 children with type 1 diabetes are diagnosed per year, of which about 75% of children who become ill for the first time are under the age of 9 years. Type 1 diabetes is characterized by complete insulin dependence, severe course, early formation of specific complications that lead to a decrease in the quality and life expectancy. Unfortunately, in more than 70% of cases, DM is diagnosed at the stage of ketoacidosis, which requires urgent measures. The main reason for the late diagnosis of this disease is the lack of "diabetic alertness" among pediatricians and AFP physicians. The foregoing obliges a wide range of doctors, including pediatricians, to know the clinical and laboratory criteria for diagnosis, modern methods of monitoring and managing diabetes, possible complications and outcomes of the disease, and be able to provide emergency care. Timely diagnosis, self-monitoring, regular monitoring, prevention of complications is an opportunity to improve the quality of life of patients with diabetes.

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Cox, Elizabeth, Mari Palta, Betty Chewning, Tim Wysocki, Tosha Wetterneck e Rosanna Fiallo-Schare. Tailoring Resources to Help Children and Parents Manage Type 1 Diabetes. Patient-Centered Outcomes Research Institute® (PCORI), agosto 2019. http://dx.doi.org/10.25302/8.2019.ih.13046279.

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Parsons, Helen M., Hamdi I. Abdi, Victoria A. Nelson, Amy M. Claussen, Brittin L. Wagner, Karim T. Sadak, Peter B. Scal, Timothy J. Wilt e Mary Butler. Transitions of Care From Pediatric to Adult Services for Children With Special Healthcare Needs. Agency for Healthcare Research and Quality (AHRQ), maggio 2022. http://dx.doi.org/10.23970/ahrqepccer255.

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Objective. To understand the evidence base for care interventions, implementation strategies, and between-provider communication tools among children with special healthcare needs (CSHCN) transitioning from pediatric to adult medical care services. Data sources. We searched Ovid MEDLINE, Ovid Embase, the Cochrane Central trials (CENTRAL) registry, and CINAHL to identify studies through September 10, 2021. We conducted grey literature searches to identify additional resources relevant to contextual questions. Review methods. Using a mixed-studies review approach, we searched for interventions or implementation strategies for transitioning CSHCN from pediatric to adult services. Two investigators screened abstracts and full-text articles of identified references for eligibility. Eligible studies included randomized controlled trials, quasi-experimental observational studies, and mixed-method studies of CSHCN, their families, caregivers, or healthcare providers. We extracted basic study information from all eligible studies and grouped interventions into categories based on disease conditions. We summarized basic study characteristics for included studies and outcomes for studies assessed as low to medium risk of bias using RoB-2. Results. We identified 9,549 unique references, 440 of which represented empirical research; of these, 154 (16 major disease categories) described or examined a care transition intervention with enough detail to potentially be eligible for inclusion in any of the Key Questions. Of these, 96 studies met comparator criteria to undergo risk of bias assessment; however only 9 studies were assessed as low or medium risk of bias and included in our analytic set. Low-strength evidence shows transition clinics may not improve hemoglobin A1C levels either at 12 or 24 months in youth with type 1 diabetes mellitus compared with youth who received usual care. For all other interventions and outcomes, the evidence was insufficient to draw meaningful conclusions because the uncertainty of evidence was too high. Some approaches to addressing barriers include dedicating time and resources to support transition planning, developing a workforce trained to care for the needs of this population, and creating structured processes and tools to facilitate the transition process. No globally accepted definition for effective transition of care from pediatric to adult services for CSHCN exists; definitions are often drawn from principles for transitions, encompassing a broad set of clinical aspects and other factors that influence care outcomes or promote continuity of care. There is also no single measure or set of measures consistently used to evaluate effectiveness of transitions of care. The literature identifies a limited number of available training and other implementation strategies focused on specific clinical specialties in targeted settings. No eligible studies measured the effectiveness of providing linguistically and culturally competent healthcare for CSHCN. Identified transition care training, and care interventions to

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Viswanathan, Meera, Jennifer Cook Middleton, Alison Stuebe, Nancy Berkman, Alison N. Goulding, Skyler McLaurin-Jiang, Andrea B. Dotson et al. Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Systematic Review of Perinatal Pharmacologic Interventions. Agency for Healthcare Research and Quality (AHRQ), aprile 2021. http://dx.doi.org/10.23970/ahrqepccer236.

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Background. Untreated maternal mental health disorders can have devastating sequelae for the mother and child. For women who are currently or planning to become pregnant or are breastfeeding, a critical question is whether the benefits of treating psychiatric illness with pharmacologic interventions outweigh the harms for mother and child. Methods. We conducted a systematic review to assess the benefits and harms of pharmacologic interventions compared with placebo, no treatment, or other pharmacologic interventions for pregnant and postpartum women with mental health disorders. We searched four databases and other sources for evidence available from inception through June 5, 2020 and surveilled the literature through March 2, 2021; dually screened the results; and analyzed eligible studies. We included studies of pregnant, postpartum, or reproductive-age women with a new or preexisting diagnosis of a mental health disorder treated with pharmacotherapy; we excluded psychotherapy. Eligible comparators included women with the disorder but no pharmacotherapy or women who discontinued the pharmacotherapy before pregnancy. Results. A total of 164 studies (168 articles) met eligibility criteria. Brexanolone for depression onset in the third trimester or in the postpartum period probably improves depressive symptoms at 30 days (least square mean difference in the Hamilton Rating Scale for Depression, -2.6; p=0.02; N=209) when compared with placebo. Sertraline for postpartum depression may improve response (calculated relative risk [RR], 2.24; 95% confidence interval [CI], 0.95 to 5.24; N=36), remission (calculated RR, 2.51; 95% CI, 0.94 to 6.70; N=36), and depressive symptoms (p-values ranging from 0.01 to 0.05) when compared with placebo. Discontinuing use of mood stabilizers during pregnancy may increase recurrence (adjusted hazard ratio [AHR], 2.2; 95% CI, 1.2 to 4.2; N=89) and reduce time to recurrence of mood disorders (2 vs. 28 weeks, AHR, 12.1; 95% CI, 1.6 to 91; N=26) for bipolar disorder when compared with continued use. Brexanolone for depression onset in the third trimester or in the postpartum period may increase the risk of sedation or somnolence, leading to dose interruption or reduction when compared with placebo (5% vs. 0%). More than 95 percent of studies reporting on harms were observational in design and unable to fully account for confounding. These studies suggested some associations between benzodiazepine exposure before conception and ectopic pregnancy; between specific antidepressants during pregnancy and adverse maternal outcomes such as postpartum hemorrhage, preeclampsia, and spontaneous abortion, and child outcomes such as respiratory issues, low Apgar scores, persistent pulmonary hypertension of the newborn, depression in children, and autism spectrum disorder; between quetiapine or olanzapine and gestational diabetes; and between benzodiazepine and neonatal intensive care admissions. Causality cannot be inferred from these studies. We found insufficient evidence on benefits and harms from comparative effectiveness studies, with one exception: one study suggested a higher risk of overall congenital anomalies (adjusted RR [ARR], 1.85; 95% CI, 1.23 to 2.78; N=2,608) and cardiac anomalies (ARR, 2.25; 95% CI, 1.17 to 4.34; N=2,608) for lithium compared with lamotrigine during first- trimester exposure. Conclusions. Few studies have been conducted in pregnant and postpartum women on the benefits of pharmacotherapy; many studies report on harms but are of low quality. The limited evidence available is consistent with some benefit, and some studies suggested increased adverse events. However, because these studies could not rule out underlying disease severity as the cause of the association, the causal link between the exposure and adverse events is unclear. Patients and clinicians need to make an informed, collaborative decision on treatment choices.

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Type 2 diabetes is becoming more common in children. National Institute for Health Research, luglio 2017. http://dx.doi.org/10.3310/signal-000451.

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Why don’t children and young people engage with diabetes services? National Institute for Health Research, marzo 2022. http://dx.doi.org/10.3310/alert_49448.

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Insulin pumps offer little value over multiple injections for children at the onset of diabetes. National Institute for Health Research, novembre 2018. http://dx.doi.org/10.3310/signal-000680.

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