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Tesi sul tema "Development"
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1
Florio, Zintel Linda. "Exploring personal development and implications for leadership". Thesis, Cranfield University, 2012. http://dspace.lib.cranfield.ac.uk/handle/1826/8044.
Testo completoAbstract (sommario):
In leadership development, an established literature and a fertile praxis fall short of clarifying how individuals may develop the many and varied capabilities that contribute to leadership processes. Literature promoting personal growth tends to reduce personal development to cognitive development or rely on broadly defined and under-evidenced notions. The adult development literature offers to this research a conceptualization of personal development as systemic qualitative change in individual sensemaking. As sensemaking develops, it progresses toward greater integration (of interdependent cognitive, emotive, purposive, and conative dimensions), sophistication, and self-determination. The research aimed to examine how changes in the sensemaking of individuals may result in developmental outcomes relevant for personal and leadership development.
This inquiry moves from a perspective idealist ontology and a social constructivist epistemology, selects philosophical hermeneutics as a research paradigm, and embraces exploratory qualitative longitudinal research. Purposive sampling guided the selection of research context, a leadership program focused on personal growth. Transcripts from 32 semi-structured constructivist-phenomenological interviews, collected from nine participants across fourteen months, were analyzed through constructivist grounded theory. Development was assessed ipsatively according to a literature-based framework. Contributions, in terms of substantive theory, are not generalizable beyond research context and sample.
This research advances the differentiation of developmental context, process and outcomes. Context is found to transcend holding environment—to be ideally conducive to a specific type of change in virtue of a distinctive emerging quality. While vector processes facilitate development, core processes (individual sensemaking) are development. In terms of outcomes, the research supports an association between personal development and development of leadership capabilities, but questions whether self-awareness or personality adjustments per se constitute authentic personal or leadership development.
This research exposes a pattern of seeking affirmation, associated with disproportionate identity salience of external image, which is potentially capable of hindering personal development by triggering maladaptive rather than adaptive self-reflection.
2
Viljoen, Linda-Mari. "Die bevordering van sosiaal-emosionele ontwikkeling by die graad 1-leerder deur middel van 'n musiekondersteuningsprogram / Linda-Mari Viljoen". Thesis, North-West University, 2007. http://hdl.handle.net/10394/1651.
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3
Cherry, Amanda M. "Methods to Characterize Orofacial Development". VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5484.
Testo completoAbstract (sommario):
In this thesis, several techniques were combined to optimize, evaluate and characterize craniofacial development in Xenopus, with additional focus on understanding the alterations made during maturation in the craniofacial region and the cartilage. Three important techniques used were: confocal microscopy in conjunction with Acridine Orange (AO) labeling, Alcian Blue (AB) labeling, and geometric morphometric analysis. I found that facial width increased across all techniques used to evaluate it. Included within this focus was the study of the development of the ceratohyal (CH) cartilage, which supported the mouth and snout. This was also found to increase width wise, in unison with facial and orofacial growth. This data may suggest a link between the face, mouth and CH growth, in which the developing cartilage elongates and widens causing the increase seen in the width and distension of the mouth.
4
Koyama, Kristina. "Studies on development in Euphilomedes ostracods: Embryology, nervous system development, and the genetics of sexually dimorphic eye development". Scholarly Commons, 2017. https://scholarlycommons.pacific.edu/uop_etds/2978.
Testo completoAbstract (sommario):
Model organism studies have been fundamental in understanding evolutionary and developmental biology. However, non-model organisms present opportunities to study unique characteristics and as comparisons to model organisms, leading us toward broader and more relevant perspectives on diversity. The Euphilomedes genus of ostracods is an example of a non-model group with potential for evolutionary and developmental studies.
Ostracoda is an ancient, basally branching lineage of Crustaceans with a complete and prodigious fossil record. Despite the group’s promise for evolutionary studies, much remains unknown about the basic biology of this clade. There are a limited number of embryogenesis studies in Ostracoda; here, I study development in Euphilomedes.
In Chapter 1, I study the main events in Euphilomedes’ embryology, focusing on cleavage and cell migration. I describe the general embryology of Euphilomedes, and devise a visual staging scheme for their development. Using fluorescent nuclear staining and microscopy, I visualize nuclei in cleavage throughout development of nuclear divisions and migrations during development. The meroblastic cleavage observed in Euphilomedes resembles that of another Myodocopid ostracod, Vargula hilgendorfii.
Finally, immunostaining for acetylated-alpha tubulin and phalloidin staining are used to visualize the general anatomy of the embryonic brain. This provides new protocols for visualizing the nervous system, enabling more detailed nervous system studies in the future.
In Chapter 2, I explore differential gene expression patterns in the developing eyes of juvenile Euphilomedes. Euphilomedes have sexually dimorphic eye types – males have lateral compound eyes, while females instead have eye rudiments. Previous studies in E. carcharodonta show that genes in the retinal determination and phototransduction gene networks have differential expression in males and females during eye development. In this thesis, we attempt to compare these patterns to expression in a sister species, E. morini.
5
Venter, Ivan. "Hotel property development : a framework for successful developments". Diss., University of Pretoria, 2006. http://hdl.handle.net/2263/23795.
Testo completoAbstract (sommario):
Although there are similarities between hotel and other commercial property developments in terms of land, structures and services, it is important when developing hotels to understand that they have unique characteristics. These unique characteristics are that hotels require specific management expertise, are usually a “single-use” property, whose primary revenue is generated from a service-based industry, and has a market value that is directly related to its ability to generate future net income. The essence of successful hotel property developments lies in understanding these unique characteristics, as illustrated in the dissertation literature review. In addition, the dissertation identifies various critical success factors for hotel development which in turn is incorporated into a hotel property development framework, establishing a practical ‘road map’ for successful hotel developments. The literature review incorporates a wide range of hotel topics, such as the principles of a hotel business, fundamentals of the tourism industry as a motivator for hotel development, property development in general, hotel property development, strategic hotel management, hotel property development feasibility studies, hotel market analysis, financial feasibility, risk management of hotel developments, financing of hotel property developments, the project team and consultants, the design phases, and finally the construction phase. The dissertation empirical study tests the validity of the hotel property development framework, by presenting it to and questioning hotel development professionals in intensive direct interviews.Dissertation (MSc(Real Estate))--University of Pretoria, 2007.
Construction Economics
unrestricted
6
Boober, Becky Hayes. "Spirited Youth/Thriving Youth: Adolescents' Perspectives on Nurturing Thriving Outcomes Through Faith Development". Fogler Library, University of Maine, 2005. http://www.library.umaine.edu/theses/pdf/BooberBH2005.pdf.
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Afflerbach, Kevin Andrew. "Humorous Developments: Ridicule, Recognition, and the Development of Agency". UNF Digital Commons, 2015. https://digitalcommons.unf.edu/etd/602.
Testo completoAbstract (sommario):
In this thesis I examine various theories of humor to establish an account of the functional roles of humor in social interaction and agentive development. These roles are integrated into a view of agency developed by G.H. Mead, and further refined by the recognition theory of Axel Honneth. The core thesis is: Humor is under-examined as an aspect of human interaction, because it plays such an integral role in individual agency and social development. Understanding how humor works helps to explain how agents are formed through the internalization of the expectations of others via processes of recognition, either positively or negatively. Through the explication of the core humor theories—superiority, relief, incongruity, and play—insight is offered into the various processes of basic human interaction, understanding, and identity.
The work has theoretical application by proving Mead's and Honneth's emphasis on recognition for development is justified, while also correcting an overly positive view of recognition by outlining the social policing function of humor. But the thesis has also obvious practical value in day to day human interaction, as it shows that humor is able to address issues that are very difficult through other modes of communication and understanding. Humor’s role in agentive interaction and formation cannot be overstated, both as a mode of expression and coping, but also since the threat of embarrassment through ridicule underpins and motivates a great deal of human interaction. The negative ethical implications of the role of humor, which are often overlooked, are extensively outlined and developed through the conceptual frameworks of social power (punching-up and punching down) as well as act-centered vs. agent-centered views of discriminatory humor. The thesis offers and analyzes ready examples from the work of Chris Rock and Bill Cosby, and looks at the implications of each through the theoretical lenses fleshed out in previous chapters. Through this it is clearly demonstrated, not only how these theories interconnect, but as well how such knowledge is of obvious, and practical value in day-to-day human interaction.
8
Keary, Cynthia (Cynthia Christina) Carleton University Dissertation Canadian Studies. "Community economic development; theoretical development". Ottawa, 1995.
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9
Palencia, Desai Sharina. "Transcriptional Regulation of Early Endocardial Development". University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1378195299.
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McKean, Cristina. "Investigating the development of a developmental disorder : mapping the trajectory of lexical development in specific language impairment". Thesis, University of Newcastle Upon Tyne, 2010. http://hdl.handle.net/10443/1612.
Testo completoAbstract (sommario):
There is increasing consensus that to understand developmental disorders we must apply developmental theoretical models and methodologies. To develop a fully specified developmental model of a developmental disorder we must understand both the nature of the innate causal processing deficits of the disorder and also how these deficits in early processing mechanisms then change the developmental process. This study aimed to examine the second of these issues with respect to Specific Language Impairment (SLI) and so describe the altered trajectory of development in this group of children. Explanatory models which propose hypothetical trajectories of development from impaired processing mechanisms in the infant to the patterns of linguistic impairments typically found in SLI are beginning to be developed. To date however there is very little empirical research which maps these trajectories. This study sought to contribute to that necessary empirical data and so to our understanding of the development of SLI. In addition it aimed to consider whether the application of a developmental methodology and perspective adds to our understanding of this disorder. A series of longitudinal case studies of children with SLI were completed. The participants were seen for four blocks of comprehensive assessment of language processing, language knowledge and "language relevant" processing over a 15 month time period. Cross sectional data from 38 typically developing (TD) children was also collected for comparison purposes. The data presented represents a part of this larger study and focuses on the development of the lexicon in SLI. Lexical and phonological processing and their interaction with phonological working memory capacity are thought to be crucial to the ontogeny of SLI. A series of tasks were developed to create a window into the nature of the developing lexicon. Data is presented from a novel non-word repetition task which manipulated the phonological characteristics of the stimuli and from a fast-mapping task where both phonological and lexical variables were manipulated. The influence of these factors on performance and changes in their influence across development were examined. Analysis of the trajectory of development of the two measures in TD children showed evidence of increasing abstraction of sub-lexical/phonological knowledge from lexical knowledge across development. In addition the developmental trajectory of fast mapping abilities demonstrated a significant and radical shift in processing bias across the age range. This result suggests that functional reorganisation in the developing lexicon, and hence the speech processing mechanism, may be taking place and which may occur as a result of increasing sub-lexical/phonological abstraction. The developmental trajectories of the children with SLI suggest that this group of children develop a different lexical processing architecture from typically developing children which does not reach the levels of efficiency of TD children's speech processing mechanisms. There is tentative support for a deficit in schema abstraction across the lexicon and an absence of functional reorganisation. The possibility that these results represent entrenchment within a self-organising network, and the possible relationship to issues of timing and critical periods is discussed. In addition it appears that compensatory strategies for this inefficient speech processing architecture may result in impaired semantic learning and so may have effects on the wider trajectory of atypical language development in SLI. Applying a developmental emergent perspective to SLI and so considering trajectories of development rather than static group comparisons can begin to uncover the nature of change within an interactive system and the nature of interdependence of processing mechanisms across development. Such an approach holds promise for revealing the nature of SLI and providing a more ecologically valid explanation of this complex disorder. The implications of developmental emergent conceptualisations of language impairment for research methodologies, diagnosis and therapy are discussed.
11
Plebanek, Daniel Joseph. "Paying Attention to Development: Understanding Developmental Differences in Selectivity". The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1499425770379572.
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Hwati, Lucky. "Participatory development (PD): NGOs and developmental practice in Zimbabwe". Thesis, University of Fort Hare, 2013. http://hdl.handle.net/10353/d1015315.
Testo completoAbstract (sommario):
The rising to prominence of Non- Governmental Organizations (NGOs) as essential partners to development was as a result of a shift in development authority into decentralized governance. Prior to this, the state was the central player in development. At liberation from political colonial control, most African governments adopted a centralized governance system. This meant that even in their drive to eco-socio development the state was the sole and most important driver. As explained by Allen (1995), in order to keep their grip on power, African leaders invented different solutions. Among them was an amplified centralization of its administrative device, or the creation of a centralized bureaucratic organization. Indeed, from 1960, the majority of African leaders banned political competition and instituted one-party regimes under which an ever-expanding bureaucracy was used to distribute resources to political allies, often under the form of membership in administrative positions (Allen, 1995). It was this need to keep a firm grip on power which saw most governments spearheading their own development, with NGOs playing a peripheral role. In the second instance, the state was instrumental in leading development. Throughout Africa, numerous government boards and ministries were created, each with a specific role to play in development (Willis, 2011; Allen, 1995). In the same way, most governments instituted policies and plans, with specific time frames, where certain development targets were supposed to be met. This system was adopted and became more pronounced in countries such as Malawi, Zambia and Zimbabwe.
13
Hoang, Tuan-Hoa Information Technology & Electrical Engineering Australian Defence Force Academy UNSW. "Evolutionary Developmental Evaluation : the Interplay between Evolution and Development". Awarded by:University of New South Wales - Australian Defence Force Academy. Information Technology & Electrical Engineering, 2009. http://handle.unsw.edu.au/1959.4/44870.
Testo completoAbstract (sommario):
This thesis was inspired by the difficulties of artificial evolutionary systems in finding elegant and well structured, regular solutions. That is that the solutions found are usually highly disorganized, poorly structured and exhibit limited re-use, resulting in bloat and other problems. This is also true of previous developmental evolutionary systems, where structural regularity emerges only by chance. We hypothesise that these problems might be ameliorated by incorporating repeated evaluations on increasingly difficult problems in the course of a developmental process. This thesis introduces a new technique for learning complex problems from a family of structured increasingly difficult problems, Evolutionary Developmental Evaluation (EDE). This approach appears to give more structured, scalable and regular solutions to such families of problems than previous methods. In addition, the thesis proposes some bio-inspired components that are required by developmental evolutionary systems to take full advantage of this approach. The key part of this is the developmental process, in combination with a varying fitness function evaluated at multiple stages of development, generates selective pressure toward generalisation. This also means that parsimony in structure is selected for without any direct parsimony pressure. As a result, the system encourages the emergence of modularity and structural regularity in solutions. In this thesis, a new genetic developmental system called Developmental Tree Adjoining Grammar Guided Genetic Programming (DTAG3P), is implemented, embodying the requirements above. It is tested on a range of benchmark problems. The results indicate that the method generates more regularly-structured solutions than the competing methods. As a result, the system is able to scale, at least on the problem classes tested, to very complex instances the system encourages the emergence of modularity and structural regularity in solutions. In this thesis, a new genetic developmental system called Developmental Tree Adjoining Grammar Guided Genetic Programming (DTAG3P), is implemented, embodying the requirements above. It is tested on a range of benchmark problems. The results indicate that the method generates more regularly-structured solutions than competing methods. As a result, the system is able to scale, at least on the problem classes tested, to very complex problem instances.
14
Meca, Alan. "Ethnic and American Identity Development: A Developmental Systems Approach". FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1123.
Testo completoAbstract (sommario):
Given the role ethnic identity has as a protective factor against the effects of marginalization and discrimination (Umaña-Taylor, 2011), research longitudinally examining ethnic identity has become of increased importance. However, successful identity development must incorporate elements from both one’s ethnic group and from the United States (Berry, 1980). Despite this, relatively few studies have jointly evaluated ethnic and American identity (Schwartz et al., 2012). The current dissertation, guided by three objectives, sought to address this and several other gaps in the literature. First, psychometric properties of the Multigroup Ethnic Identity Measure (MEIM) and the American Identity Measure (AIM) were evaluated. Secondly, the dissertation examined growth trends in recently immigrated Hispanic adolescents’ and their caregivers’ ethnic and American identity. Lastly, the relationship between adolescents’ and caregivers’ ethnic and American identity was evaluated. The study used an archival sample consisting of 301 recently immigrated Hispanic families collected from Miami (N = 151) and Los Angeles (N = 150). Consistent with previous research, results in Study 1 indicated a two-factor model reliably provided better fit than a one-factor model and established longitudinal invariance for the MEIM and the AIM. Results from Study 2 found significant growth in adolescents’ American identity. While some differences were found across site and nationality, evidence suggested recently immigrated Hispanic adolescents were becoming more bicultural. Counterintuitively, results found a significant decline in caregivers’ ethnic identity which future studies should further examine. Finally, results from Study 3, found several significant positive relationships between adolescents’ and their caregivers’ ethnic and American identity. Findings provided preliminary evidence for the importance of examining identity development within a systemic lens. Despite several limitations, these three studies represented a step forward in addressing the current gaps in the cultural identity literature. Implications for future investigation are discussed.
15
Smith, Mary Clare. "Relationships among Cognitive, Spiritual, and Wisdom Development in Adults". Cleveland State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=csu1340804343.
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Green, Jack Ellis. "The evolution of development : insights from the centipede Strigamia maritima". Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708608.
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FERREIRA, ANDREA TEIXEIRA ACIOLI. "DEVELOPMENT FOR EXPORT: WHEN THE DEVELOPMENT OF NGOS CLASHES WITH COLLECTIVITIES DEVELOPMENT". PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2010. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=16703@1.
Testo completoAbstract (sommario):
COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOREste estudo é decorrente de alguns anos de pesquisa sobre as Organizações Não-Governamentais (ONGs), seu surgimento, atuação e mais recentemente acerca dos resultados obtidos através de suas ações. Devido à proximidade com o objeto pudemos perceber que atualmente há uma grande quantidade de ONGs que se territorializam a partir de uma atuação centrada no desenvolvimento por elas desejado. Partiremos então em busca da compreensão de como diferentes noções de desenvolvimento podem interferir nas relações de uma coletividade, tentando entender se esses projetos de desenvolvimento, da maneira como costumam ser implementados, são capazes de atender às reais necessidades dessas coletividades. Para isso utilizaremos autores como Cornelius Castoriadis (1987, 1992), Edgar Morin (1999), Antonio Gramsci (1991, 2002) e Marcelo Souza (1996 e 2006), que nos servirão de base e nos auxiliarão no entendimento das questões apresentadas.
This study is the result of several years of research on the Non- Governmental Organizations (NGOs), its appearance, performance and more recently on the results achieved through their actions. Given its proximity to the object we see that currently there are a lot of NGOs that would territorialized from an activity centered on the development they want. Then depart in search of understanding of how different notions of development may interfere in the relations of a community, trying to understand whether those development projects, the way they are usually implemented, are capable of meeting the real needs of these communities. For this we use authors as Cornelius Castoriadis (1987, 1992), Edgar Morin (1999), Antonio Gramsci (1991, 2002) and Marcelo Souza (1996 and 2006), we will provide the basis and assist in the understanding of the issues presented.
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Harrison, Sarah Ellys. "Utilising embryonic and extra-embryonic stem cells to model early mammalian embryogenesis in vitro". Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275424.
Testo completoAbstract (sommario):
Successful mammalian development to term requires that embryonic and extra-embryonic tissues communicate and grow in coordination, to form the body. After implanting into the uterus, the mouse embryo is comprised of three cell lineages: first, the embryonic epiblast (EPI) that forms the embryo proper, second, the extra-embryonic ectoderm (ExE) which contributes to the foetal portion of the placenta, and third, the visceral endoderm (VE) that contributes to the yolk sac. These three tissues form a characteristic ‘egg-cylinder’ structure, which allows signals to be exchanged between them and sets the stage for body axis establishment and subsequent tissue patterning. The mechanisms underlying this process are difficult to study in vivo because a different genetically manipulated mouse line must be generated to investigate each factor involved. This difficulty has prompted efforts to model mammalian embryogenesis in vitro, using cell lines, which are more amenable to genetic manipulation. The pluripotent state of the EPI can be captured in vitro as mammalian embryonic stem cells (ESCs). Although mouse ESCs have been shown to contribute to all adult tissues in chimeric embryos, they cannot undertake embryogenesis when allowed to differentiate in culture. Previous studies have shown that ESCs formed into three-dimensional (3D) aggregates, called embryoid bodies, can become patterned and express genes associated with early tissue differentiation. However, embryoid bodies cannot recapitulate embryonic architecture and therefore may not accurately reflect what happens in the embryo. In this study, a new technique was developed to model early mouse development which is more faithful to the embryo. ESCs were co-cultured with stem cells derived from the ExE, termed trophoblast stem cells (TSCs), embedded within extracellular matrix (ECM). These culture conditions lead to the self-assembly of embryo-like structures with similar architecture to the mouse egg cylinder. They were comprised of an embryonic compartment derived from ESCs abutting an extra-embryonic compartment derived from TSCs, and hence were named ‘ETS-embryos’. These structures developed a continuous cavity at their centre, which formed via a similar sequence of events to those that lead to pro-amniotic cavity formation in the mouse embryo, and required active Nodal/Activin signalling. After cavitation, ‘ETS-embryos’ developed regionalised mesodermal tissue and primordial germ cell-like cells originating at the boundary between embryonic and extra-embryonic compartments. Inhibitor studies revealed that this occurred in response to endogenous Wnt and BMP signalling, pathways which also govern these tissue specification events in the early mouse embryo. To demonstrate that ‘ETS-embryos’ were comparable to mouse embryos at the global transcriptional level, RNA-sequencing was then performed on different tissue regions of ‘ETS-embryos’ and the resulting transcriptomes were compared to datasets from mouse embryos. These data showed that ‘ETS-embryos’ were highly similar to mouse embryos at post-implantation stages in their overall gene expression patterns. Taken together, these results indicate that ‘ETS-embryos’ are an accurate in vitro model of mammalian embryogenesis, which can be used to complement studies undertaken in vivo to investigate early development.
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Darby, Kevin Patrick. "Interference Effects and Memory Development". The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1491233945346347.
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Wong, Caitlin Aymong. "Character development and the role of individual & contextual supports:". Thesis, Boston College, 2019. http://hdl.handle.net/2345/bc-ir:108504.
Testo completoAbstract (sommario):
Thesis advisor: Jacqueline V. LernerThis dissertation considered character development in adolescence from a relational developmental systems (RDS) perspective through the estimation of trajectories of five character attributes and the associations of these trajectories with the contextual factors of intentional self-regulation (ISR) and prosocial socialization from role models whom adolescents reported knowing personally. Character attributes considered were honesty, humility, diligence, future mindedness, and purpose. Data were taken from the Connecting Adolescents' Beliefs and Behaviors longitudinal study of character development in adolescents from the Northeastern United States. Results demonstrated that multiple trajectories can be estimated for each character attribute, supporting the RDS principles of plasticity and individual differences. Associations were also found among all character attributes considered at every time point. Contextual factors had more nuanced relationships with character attribute trajectories than was expected, with high levels of ISR associated with high start points for all character attributes and for overall character attribute patterns, but not necessarily with sustained high levels of character attributes. Prosocial socialization did not demonstrate a stable association with high levels or increasing levels of any character attribute examined. This pattern of findings suggests that additional contextual aspects should be considered as important aspects of character development. Limitations and future directions are discussed
Thesis (PhD) — Boston College, 2019
Submitted to: Boston College. Lynch School of Education
Discipline: Counseling, Developmental and Educational Psychology
21
Goulielmos, Markos. "Organisation development and successful information systems development". Thesis, Sheffield Hallam University, 1998. http://shura.shu.ac.uk/3096/.
Testo completoAbstract (sommario):
This thesis represents a qualitative study of the Information Systems Development (ISD) process and puts forward the argument that IS development leads to Organisation Development (OD). The thesis argues that an OD perspective should be incorporated into the main ISD paradigm and provide the basis for transformation in the field which is plagued by failure. The thesis reviews both the IS development and Organisation Development literature and makes connections between the two fields, as in practice they are both comparable activities. With the qualitative framework, Grounded Theory Methodology was used to guide research and analytical activities. We conducted research in 6 large and largemedium sized consultancy firms and in 5 large organisations that utilised non-traditional approaches to ISD. Fieldwork and analysis resulted in the emergence of an ISD process theory that explains how information systems are developed within the organisational context. The theory provided the basis from which we could more rigorously understand the true nature of IS development and determine the nature of a suitable OD contribution. In this thesis, the superiority of an OD-informed solution is argued in detail and contrasted to other proposals from the ISD field. The OD contribution is distinguished in: a) formulating an OD-informed ISD approach, we have termed the Total Systems Development Approach (TSD), b) defining a diagnostic model of ISD practice, c) and providing an extensive collection of OD improvement programmes and techniques that have direct application to ISD. The contribution the thesis makes is also multi-level. At one level we have contributed in rectifying the lack of research in the area of "process" in IS development. In doing so we have provided the basis from which the aspects of the ISD process can be explored in detail. The emergent ISD process theory itself confirms arguments that ISD is a complex socio-technical and organisational process. It highlights aspects of development that have been traditionally outside the ISD paradigm. Our theory helps readdress and challenge a number of elements in the ISD process. The notion of approach emerges as much more suitable for solving ISD problems than methodology. The role of the ISD consultant also emerges as requiring a range of appropriate consultation modes to deal with intervention complexity. Our results also show that the role of the client is much more involving and demanding than previously assumed. Another area of contribution is the formulation of the TSD approach which focuses on the development of the total system: the organisation, through IS or system development activities. It is holistic, iterative, it allows flexible problem-solving, collaboration and focuses on change, intervention and reflection. A final area of contribution is in establishing a link between OD content and IS development. With the advent of new types of development, OD "interventions" have an increasing applicability to ISD situations. The diagnostic model of ISD practice also utilizes an OD-perspective to facilitate diagnosis of organisational failure that leads to IS failure.
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Gardner, Christian Kem 1972. "Mixed-use development : a development case study". Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/26728.
Testo completoAbstract (sommario):
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Architecture, 2004.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Includes bibliographical references.
by Christian Kem Gardner.
S.M.
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Cloete, Harlan C. A. (Harlan Courtenay Alva). "Skills development and organisational development : an assessment". Thesis, Stellenbosch : Stellenbosch University, 2001. http://hdl.handle.net/10019.1/52452.
Testo completoAbstract (sommario):
Thesis (MPA)--Stellenbosch University, 2001.ENGLISH ABSTRACT: Education and training under apartheid can at best be described as fragmented and unequal along racial lines. The consequence of the decades of human resource neglect resulted in the virtual destruction of human resource potential, with devastating effects for social and economic development. At the organisational level witness to this has been the lack of career paths offered to workers and the debilitating effect on worker motivation and general productivity. In response to this state of affairs the South African government introduced a number of innovative laws aimed at reversing this downward spiral: The Skills Development Act, 1998 and the related legislation have as their single objective the establishment of a more enabling and responsive human resource environment. This will amount to the rebuilding of the South African workforce within organisations through the introduction of new sets of human resource processes, policies and principles. This study compares the activities of the Pioneer Foods Group with those of the Drakenstein Municipality in relation to the skills development regulatory framework and the subsequent obligations it places on organisations to establish new human resource practices. The study goes further and seeks to establish whether there is a causal link between the processes of skills development and Organisational Development (00). The study concludes that there is a definitive link between the skills development regulatory framework and 00. The two processes are regarded as mutually supportive, leading to the achievement of individual and organisational end goals.
AFRIKAANSE OPSOMMING: Opvoeding en opleiding onder die Apartheidsregering kan beskryf word as gefragmenteerd, ongelyk en geskoei op ras. Die gevolge van dekades van menslike hulpbron vernalting het geweldige en verreikkende ekonomiese en sosiale implikasies tot gevolg gehad. 'n Nadere blik op die vlak van organisasies dui aan dat vir werkers geen beroeps vooruitsigte was nie met die gevolg dat die motiverings vlak en veral produktiwiteit ontsettend laag was. Die respons vanaf die Suid Afrikaaanse regering was die bekendmaking van 'n reeks innoverende wetgewing gemik om die afwaartste kurwe te stop. Die Vaardigheids Ontwikkeling Wet, 1998 en die ander meegaande wette het as primêre doelwit die daarskep van "n meer verantwoordelike menslike hulpbron klimaat. Dit het ten doel die heropbou van die Suid Afrikaanse mense deur die bekendmaking van "n stel menslike hulpbron prosessese, beleid en beginsels. Hierdie studie fokus en vergelyk die vaardigheidsontwikkeling aktiwiteite van die Pioneers Voedsel Groep met die van die Drakenstein Munisipaliteit. Die studie gaan verder deur vas stel of daar n definitiewe verband is tussen die prossese van vaardigheidsontwikkeling en die van organisasie ontwikkeling. Die slotsom is die volgende: dat daar 'n definitiewe verbintenis is tussen vaardigheidsontwikkeling en organisasie ontwikkeling. Die twee prossese steun op mekaar deurdat beide ten doel het 'n verbeterde organisasie en individu, soos hulle strewe na die bereiking van doelwitte.
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Broce, Iris J. "Brain Networks Supporting Literacy Development". FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/3040.
Testo completoAbstract (sommario):
The development of fluent reading requires coordinated development of key fiber pathways. While several fiber pathways have been implicated in reading, including the recently re-identified vertical occipital fasciculus (VOF), inferior longitudinal fasciculus (ILF), arcuate fasciculus and its 3 components, and inferior fronto-occipital fasciculus (IFOF), whether these fiber pathways support reading in young children with little to no exposure to print remains poorly understood. Consequently, over the course of three studies, the current dissertation aimed to narrow this research gap by addressing the following research questions: 1) Which fiber pathways support early literacy skill in young children 5-10 years old? 2) Are microstructural properties of these tracts predictive of age-related changes in reading across an interval of two years? 3) Do different components of the recently identified VOF differentially support reading? To answer these questions, we used diffusion-weighted imaging to measure white-matter development and to relate the microstructural properties of each fiber pathway to early literacy and literacy development. We report several novel findings that contribute to our growing understanding of the white matter connections supporting early literacy and literacy. For the first time, these studies revealed that the re-identified VOF can be reliably tracked in young children, bilaterally and is composed of three main components, which project from occipital temporal sulcus to angular, and middle and superior occipital gyri. We also found that the left AF, bilateral ILF, and particular components of the VOF play a role in early literacy and literacy development. Implications for contemporary models of reading development are discussed.
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Darden, Jordan Alexandra. "Pericytes in Early Vascular Development". Diss., Virginia Tech, 2019. http://hdl.handle.net/10919/89057.
Testo completoAbstract (sommario):
Blood vessels are critical for the delivery of oxygen and nutrients to all cells in the body. To properly function, blood vessels and their primary components must develop and mature into a healthy network, capable of dynamic alterations to meet new needs of the body. The early genetic and molecular programs that "push" the vasculature to develop are the same programs that reactivate when there are normal changes to the body such as injury, muscle growth or decline, or aging; and when pathologies arise like cancer, stroke, and diabetes. Therefore, it is crucial to understand how the vasculature develops into a healthy system by studying all components as they mature.
Endothelial cells that comprise the vessels themselves are joined by specialized partner cells called pericytes that help guide and mature vessel growth. Pericytes lie elongated along endothelial cells and have multiple points of contact with the endothelium. In this position, pericytes assist in cell-cell communication and even blood flow regulation in the microvasculature. To study the relationship between endothelial cells and pericytes during development, we observed vascular morphology in three and four dimensions, as well as the genetic and molecular mechanisms underlying how these cells are recruited and interact in several experimental models. Thus, to thoroughly analyze the morphology of these vessels, we developed a rigorous methodology using a MATLAB program to determine the colocalization and coverage of pericytes associated with vessels in large image sets. After developing analytical methods to investigate all the components of the blood vessel wall, we expanded our investigation of how pericytes and other aspects of microvasculature develop in animal models, specifically a more commonly used murine model for vascular development and for treatment of human diseases. Our findings of vascular development in mice suggest that there are important differences in how human and mouse brain blood vessels form. Therefore, studies using mice must be carefully designed to account for these discrepancies. Additionally, research into why human and mouse neurovascular development and maturation are different can aid in the development of improved experimental models to better treat human pathologies.Doctor of Philosophy
Blood vessels have the crucial job of delivering oxygen and nutrients to all the cells in the body. To perform this duty, blood vessels- and the components that make them- must develop and mature into a healthy network, capable of altering itself to meet new needs of the body. The early programs that “push” the vessel system to develop are the same programs that reactivate when there are normal changes to the body such as injury, muscle growth or decline, or aging; and when abnormal diseases arise like cancer, stroke, and diabetes. Therefore, it is critical to understand how blood vessels develop into healthy systems by studying all of their components as they mature. Endothelial cells that comprise the vessels themselves are joined by specialized partner cells called pericytes that help guide and mature vessel growth. Pericytes lie elongated along endothelial cells and have multiple points of contact with the endothelium. In this position, pericytes assist in cell-cell communication and even blood flow regulation in smaller vessels called capillaries. To study the relationship between endothelial cells and pericytes during development, we observed vascular anatomy in three and four dimensions, as well as mechanisms underlying how these cells come together and interact in several experimental models. Thus, to thoroughly analyze the morphology of these vessels, we developed a rigorous methodology using a MATLAB program to determine the colocalization and coverage of pericytes associated with vessels in large image sets. After developing analytical method to investigate all the components of the blood vessel wall, we expanded our investigation of how pericytes and other aspects of blood vessels develop in animal models, specifically a more commonly used animal model for vascular development and for treatment of human diseases. Our findings of vascular development in mice suggest that there are important differences in how human and mouse brain blood vessels form. Therefore, studies using mice must be carefully designed to account for these discrepancies. Additionally, research into why human and mouse neurovascular development and maturation are different can aid in the development of improved experimental models to better treat human illness and injury.
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Fierro, Jr Javier. "Glutamatergic Synapse Formation in Developing Zebrafish Embryos". Thesis, University of Oregon, 2015. http://hdl.handle.net/1794/18752.
Testo completoAbstract (sommario):
In order for a human being to process complex thought, cells within the brain must communicate with each other in a very precise manner. The mechanisms which underlie the development of these connections, however, are poorly understood and thus require a thorough investigation. In this dissertation, we attempt to identify components involved in stabilizing synaptic contacts and the mechanisms by which synaptic proteins are trafficked to newly forming contact sites. Interestingly, we also identify a gene involved in the formation of the myotome.
To identify proteins involved in stabilizing synaptic contacts, we characterized the function of 4.1B in developing zebrafish embryos. 4.1B is a scaffolding molecule involved in stabilizing protein complexes at sites of cell adhesion. We identified two 4.1B genes in the zebrafish genome, 4.1B-a and 4.1B-b, which are differentially expressed and have evolved divergent functions. 4.1B-a is expressed within the central nervous system, specifically within primary motor neurons. Knockdown studies show a reduction in the number of synapses and altered kinetics of touch evoked-responses, suggesting a role in synaptic stabilization. In contrast, 4.1B-b is primarily expressed in muscle cells. Knockdown of 4.1B-b results in severe muscle fiber disorganization as well as altered locomotor behaviors. Together, these data suggest the basic functions of 4.1B are evolutionarily conserved, with new roles described in the development of synapses and muscle fibers.
To determine the mechanisms that underlie protein recruitment to newly forming synapses, we examined the recruitment of three distinct transport packets in the zebrafish spinal cord. During presynaptic assembly, we found synaptic vesicle protein transport vesicles preceded piccolo-containing active zone precursor transport vesicles, which in turn preceded synapsin transport vesicles. We identified the last transport packet as a unique and independent mechanism for the recruitment of synapsin, a protein involved in regulating the reserve pool of synaptic vesicles. Importantly, we found cyclin-dependent kinase 5 regulated the late recruitment of synapsin transport packets to synapses, thus identifying kinases as a key signaling molecule in the formation of synaptic contacts. Together, this work provides new insight into the mechanisms that underlie synaptogenesis.
This dissertation includes both previously published and unpublished co-authored material.
27
Tissell, Rachel L. "Child maltreatment risk| Associations with mothers' representations of childhood attachment, trauma, caregiving, and regulation". Thesis, Mills College, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10163157.
Testo completoAbstract (sommario):
Child maltreatment models view risk as a complex constellation of factors that emphasize parents’ trauma experiences and regulation processes. Attachment research has shown that mothers’ representations of childhood attachment and caregiving places their children at developmental risk. Studies to date have evaluated contributing factors separately, but little research considers mothers’ past and current experiences combined with relational trauma and familial regulation patterns. The current research adopted an integrated perspective using known maternal risk factors, and extended existing research in several unique ways by examining association with both adult trauma and childhood trauma; caregiving representations; pathological mourning; and capacity for emotion regulation. Seventy-five mothers with children between 19-74 months (40% boys) from diverse socio-economic and cultural backgrounds completed assessments of maltreatment risk, adult attachment, caregiving, relational trauma, parenting stress, and emotion regulation. Maternal representations of attachment were significantly related to risk, with unresolved mothers demonstrating the highest risk. There were significant positive associations between risk and relational trauma – both frequency and subjective distress with parents and partners. Helpless and heightened caregiving representations, parenting stress, and emotion regulation were also all significantly related to risk. This is the first study to consider maltreatment in the context of relational trauma as defined by Bowlby’s (1980) model of pathological mourning. Risk scores were significantly greater for mothers classified in pathological mourning groups than other mothers. These findings punctuate the effects of problems associated with mourning attachment trauma on maternal regulatory capacities and parenting risk. Implications for infant mental health research and intervention are discussed.
28
Dai, Qi. "Chromatin regulators and transcriptional control of Drosophila development". Doctoral thesis, Stockholm : Wenner-Gren Institute for Experimental Biology, Stockholm University, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7209.
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Daurer, Vanessa. "What is Development? : Peruvian local perception on “development” and foreign development aid- a way to a “non-westernized” development?" Thesis, Högskolan Väst, Avd för juridik, ekonomi, statistik och politik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-4393.
Testo completoAbstract (sommario):
Abstract“Development” is an essentially contested concept within academia and some critics, the so-called post-development school, argue that the concept and practice of development is a world-view monopolizing our imagination. The school of thought promotes alternative ways to think about development but is merely at the theoretical level and lacks taking into account empirical cases. Therefore, this theoretical approach is to test and develop existing literature and the theory is originating from the work of Michel Foucault and theory of post-development’s presented hegemonic development discourse. The aim is to study Peruvian NGO executives’ perceptions on development and alternative development collaborations through in-depth interviews and a critical case study design. The study reveals an alternative thinking about “development” and local perceptions challenge the “truth” of the hegemonic development discourse. A donor-recipient relation is visible where local knowledge is limited and local NGOs are coerced into new behaviors to satisfy donors’ demands. Studying “periphery” grass-root voices from the Third World is important to be able to imagine “development” differently in discourses silenced, limited and at the margins.
30
Mbiko, Nkosiyakhetha Headman. "Developmental needs of HRD practitioners in the South African Public Service". Diss., University of Pretoria, 2012. http://hdl.handle.net/2263/25721.
Testo completoAbstract (sommario):
The purpose of the study was to determine the developmental needs of HRD practitioners in selected departments of the South African Public Service. Developmental needs as an independent variable and the role of HRD practitioners – marketing HRD interventions, conducting training needs analyses, designing and developing HRD interventions, implementing HRD interventions, and monitoring, evaluating and giving feedback on HRD interventions - were investigated. A sample of seventy (70) HRD practitioners working in seven public service departments was drawn. The developmental needs to market HRD interventions, conduct training needs analyses, design and develop HRD interventions, implement HRD interventions, and monitor, evaluate and give feedback on HRD interventions were determined within and between HRD practitioners and public service departments to establish differences and similarities. Results averred that HRD practitioners have developmental needs to perform the abovementioned functions. However, compared to Blacks and Whites, Coloureds and Indians seem to have more developmental needs in marketing, conducting training needs analysis, implementing HRD interventions and generic HRD skills. HRD practitioners from the departments of Health and Transport seemed to have more developmental needs in conducting training needs analyses and designing and developing HRD interventions when compared to other public service departments. Females need more development in marketing and implementing HRD interventions than males. HRD practitioner developmental needs in implementing, monitoring, evaluating, and giving feedback on HRD interventions were the same for all age groups. HRD practitioners in the department of Health and Transport need more development in generic skills compared to other departments. However developmental needs on generic skills are the same for all age groups.Dissertation (MCom)--University of Pretoria, 2012.
Human Resource Management
unrestricted
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Cunningham, Brittany E., e Nikki L. Adams. "Zinc Sunscreens Affect Development of Strongylocentrotus Purpuratus Embryos". DigitalCommons@CalPoly, 2018. https://digitalcommons.calpoly.edu/theses/1861.
Testo completoAbstract (sommario):
The growing popularity of physical sunscreens will also lead to an increased release of the ingredients from zinc oxide (ZnO) sunscreens into marine environments. Though zinc (Zn) is a necessary micronutrient in the ocean, greater than natural Zn concentrations are being released into marine environments by use of sunscreens. The extent of the consequences of the addition of Zn to the ocean are not fully understood. We investigated effects of materials released by zinc oxide (ZnO) sunscreens on the development of California purple sea urchin, Strongylocentrotus purpuratus. Embryos developed in various concentrations of Zn, the sources of which included zinc-containing compounds: ZnO and ZnSO4; and ZnO sunscreens: All Good, Badger, and Raw Elements. ZnO sunscreens were slightly more toxic than ZnO and ZnSO4, suggesting that the sunscreens may release additional unknown materials that are detrimental to sea urchin embryo development. All concentrations of Zn exposure resulted in significant malformations (skeletal abnormality, stage arrest, axis determination disruption), which were identified using light and fluorescent confocal microscopy. Developing embryos internalize Zn2+in proportion to the concentration of Zn in their environment. Additionally, both ZnO sunscreens and ZnO and ZnSO4at 1ppm Zn, significantly increased calcein-AM (CAM) accumulation, indicating decreased multidrug resistant (MDR) transporter activity. This is the first research that we know of to show that ZnO sunscreens release high concentrations of Zn that are internalized by and have detrimental effects on aquatic organisms.
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Koenig, Andrew L. "Novel Mechanisms of Blood and Lymphatic Vessel Development". University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1522413280582749.
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Barbosa, Heloiza Helena de Jesus. "Numerical abilities in preschool children with atypical development: a developmental description". Thesis, Boston University, 2004. https://hdl.handle.net/2144/33402.
Testo completoAbstract (sommario):
Thesis (Ed.D.)--Boston UniversityPLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.
The present study investigated the atypically developing preschool children's numerical abilities in a variety of tasks. The microgenetic methodology was employed in this study in order to capture the change and variability of the participants' numerical abilities. First, it used a matching task to investigate the participants' ability to recognize equivalence in sets composed of high and low similarity items. Second, the abilities involved in counting, calculation, and production of a given numerical set was studied through different task, such as: Board Game, Give-A-Number, and Calculation. The results indicated that while atypically developing children are able to recognize equivalence by the age of 4 Y2 years in sets of high and low similarity, this ability is not generalized to all kind of contexts yet. Instead, participants did better in a context that provides perceptual and conceptual support. In addition, the results from counting, calculation, and production of a set revealed that there is a gradual development of these numerical abilities, which are initially isolated and context dependent and later become more integrated. The results also suggest that the learning of mathematics involves the interrelation of procedural and conceptual knowledge. Furthermore, participants showed different profiles of understanding according to their individual differences. In order to create effective educational programs and to assess mathematical di fficulties in children developing atypically, researcher and teachers need to collect information about the factors that might influence the development of mathematical abilities. This study contributed to the growth ofthis knowledge.
2031-01-01
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Dohn, Tracy E. "Roles of Wnt signaling and Nr2f1a during zebrafish cardiac development". University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1427983237.
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35
Scheyvens, Henry 1965. "Evaluating aid : the developmental impact of Japan's official development assistance". Monash University, School of Political and Social Inquiry, 2001. http://arrow.monash.edu.au/hdl/1959.1/8632.
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Yuen, Miu-chun Christine, e 袁妙珍. "The challenge of conservation, development and sustainable developmentin Hong Kong". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31260172.
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Ethington, Kalene Mears. "Developmental Stages Associated with Organizational Learning: An Instrument Development Study". BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/8287.
Testo completoAbstract (sommario):
Background: Previous research has identified four distinct developmental stages associated with organizational learning in high-performing hospital units: identity and ownership, team and respect, accountability and support, and reliability and sustainability. We designed a research instrument to measure these constructs. The purpose of this thesis was to establish the content and predictive validity of this instrument.Methods: The Organizational Learning Development Instrument (OLDI) consists of a total of 35 items in Likert-scale format. Item-level and instrument-level content validity were assessed using three cycles of cognitive interviewing with 28 nurses, and eight expert ratings. The OLDI was administered to nurses in Magnet® hospitals via a web-based survey. National Database of Nursing Quality Indicators (NDNQI) and Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) reports were used for comparison of hospital performance. Predictive validity was tested using multiple linear regression. Based on a power analysis for multiple linear regression, reaching 80% power, with a medium effect size of 0.15, an alpha of 0.05, and five predictor variables, the target sample size was 92 hospital units.Results: Results from 63 inpatient units in 11 Magnet® hospitals were used. The scale- level content validity for this instrument was 0.95 and item-level content validity index scores ranged from 0.86 to 1.0, suggesting excellent content validity. No significant relationships were found between OLDI results and NDNQI measures. Significant correlations (P<.05) were found between several OLDI constructs and HCAHPS composites.Discussion: Correlations with HCAHPS scores help validate the OLDI, as well as the theory underlying the instrument. The OLDI may not have predicted NDNQI measures due to a lack of instrument sensitivity or because NDNQI results are strongly influenced by other factors. Nurse managers can use the OLDI to predict unit performance related to patient satisfaction and to determine actions that may improve unit performance. Replicating this study with a larger sample size and more diverse hospital performance and more uniform unit type could further validate this instrument.
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Alder, Olivia A. "Epigenetic regulation of key developmental genes during early mouse development". Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/5689.
Testo completoAbstract (sommario):
In undifferentiated ES cells, many Polycomb Repressive Complex 2 (PRC2) target genes carry not only repressive H3K27me3 but are also enriched for conventional indicators of active chromatin including methylated H3K4. This so-called bivalent domain structure is thought to silence key developmental regulators while keeping them poised for future activation (or repression). Consistent with this hypothesis, bivalent genes assemble RNAP II preferentially phosphorylated on Serine 5 residues (poised RNAP II) and are transcribed at low levels. Productive expression is, however, prevented by the action of PRC1. Here, I have focused on the pre-implantation stage of mouse development to evaluate whether bivalent or poised chromatin signatures are indeed specific attributes of emerging pluripotent cells and investigate how the fate of key developmental genes is specified while the first lineage decision event (extra-embryonic lineage formation) occurs. Using blastocyst-derived stem cells and chromatin immunoprecipitation (ChIP), I have shown that lineage-inappropriate genes retain bivalent histone marking in extra-embryonic trophoblast stem (TS). However, and in contrast to ES cells, PRC1 (Ring1B) and poised RNAP II are not recruited to these loci in TS cells, indicating that gene priming is a unique hallmark of pluripotent cells in the early embryo. To investigate the intricate relationship between lineage identity and dynamic chromatin changes, I exploited the potential to convert ES cells into trophoblast-like stem (TSL) cells using a previously established artificial system dependent on doxycycline (Dox) induced repression of an Oct4 transgene. I demonstrated that Suv39h1-mediated H3K9me3 alongside DNA methylation is targeted to PRC2-bound bivalent, lineage-inappropriate genes upon trophectoderm lineage commitment. A change in chromatin conformation was observed upon differentiation of ES cells to TSL cells comparable to that seen in TS cells derived in the traditional manner from the trophectoderm (TE) of blastocyst stage embryos. Most importantly, I have begun to explore when epigenetic differences are specified, at the locus level, from 8-cell stage embryos onwards using newly designed Carrier ChIP technology. This data validated the occurrence of bivalent chromatin domains in vivo and further support the view that alternative strategies operate in the TE to silence key developmental regulators upon blastocyst lineage segregation.
39
Adams, Jessica Lyn. "Multiracial identity development : developmental correlates and themes among multiracial adults /". Connect to resource, 1997. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=osu1250186768.
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Barnes, Kelly Anne. "Implicit learning in typical development and children with developmental disorders". Connect to Electronic Thesis (ProQuest), 2008. http://0-gateway.proquest.com.library.lausys.georgetown.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3320707.
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Corbett, Fleur Phaedra. "Visual motion processing in typical development and developmental coordination disorder". Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/10039362/.
Testo completoAbstract (sommario):
This thesis is concerned with the maturation of global motion coherence sensitivity in typical development and in Developmental Coordination Disorder (DCD), in relation to the dorsal stream vulnerability hypothesis. Dorsal stream vulnerability, indicated by poorer coherence sensitivity to motion relative to form, has been reported in many neurodevelopmental disorders. As dorsal stream networks underpin a cluster of visuomotor, visuospatial and oculomotor functions, in addition to motion perception, both visuomotor ability and motion coherence sensitivity were examined. Coherence sensitivity to rotational, radial and translational motions was compared with behavioural and electrophysiological techniques. Results indicated that typical adults show greatest coherence sensitivity to rotational motion, followed by radial and translational motions, and distinct patterns of coherence-sensitive visual event-related potentials for each motion. Discrimination of motion direction was better than coherent motion detection, consistent with models of the neural representation of motion coherence. In typical 6-14 year olds, coherence sensitivity to form matured earlier than to motion, with developmental trajectories converging in adulthood. Children’s coherence sensitivity matured earlier for radial motion than rotational or translational motions. These studies provide the first normative data for the maturation of coherence sensitivity to radial, rotational and translational motions and form, demonstrating asynchronous development and differential coherence sensitivity to each motion. In adults with DCD, coherence sensitivity to both motion and form was impaired relative to typical adults but adults with DCD were not selectively disadvantaged in using motion information in a visuomotor context. Young children with DCD showed a specific deficit in coherence sensitivity to motion relative to form, concordant with the dorsal stream vulnerability concept. Motor impairment correlated with motion coherence sensitivity in children with DCD. These studies showed that dorsal stream impairments could have a role in the early development of DCD, even when not evident in later development, when poor motor competency persists.
42
Moore, Thurla. "The impact of career development classes on the identity development and career self efficacy of traditional aged college students". Columbus, OH : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1054144903.
Testo completoAbstract (sommario):
Thesis (Ph. D.)--Ohio State University, 2003.Title from first page of PDF file. Document formatted into pages; contains viii, 163 p. Includes abstract and vita. Advisor: Robert Rodgers, College of Education. Includes bibliographical references (p. 130-135).
43
Bullard, Daniel Peterson. "The impact of context manipulation on knowledge development in a balancing task". University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1258741368.
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44
Harrison, James Ray. "Structural Aspects of Loevinger's Model of Ego Development". Thesis, North Texas State University, 1985. https://digital.library.unt.edu/ark:/67531/metadc504211/.
Testo completoAbstract (sommario):
The study reviews the structural and psychometric underpinnings of Loevinger's theory of ego development. It is noted that the current literature investigating the validity of Loevinger's model has not adequately addressed the structural assumptions of the theory. "Process" variables are hypothesized to vary depending on the process of structural change. Two such variables, cognitive complexity and the organization of cognitive constructs, were measured in 73 college students, staff, and faculty members in three North Texas institutions. Level of ego development, measured by the Washington University Sentence Completion Test, was assessed in each subject and the pattern of cognitive complexity and construct organization was evaluated across ego levels. Results offer only limited support for the stage model's structural assumptions. Discussion highlights several inadequacies in Loevinger's instrument and offers a direction for possible revision. Implications of the results are examined in terms of current theoretical issues.
45
Stokes, Debra Mary. "Indigenous communities sustainable development framework for LNG developments in Northwest B.C". Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/63268.
Testo completoAbstract (sommario):
The extractives sector has the obligation to contribute to sustainable development in areas where resource exploitation occurs. Fulfilling this expectation is challenging in resource-dependent towns, that are periodically exposed to boom-bust dynamics. In northwest British Columbia, several large Liquefied Natural Gas (LNG) terminal projects have been proposed, involving high capital costs and several thousand workers for the construction phase. Indigenous Peoples are often negatively affected by such large developments, as their culture and sustenance is tied to the land and water. Many of these peoples are also unable to benefit from such developments, due to a lack of support mechanisms and the necessary training or education required for good paying jobs. This study investigates how large resource developments can contribute to sustainability in B.C. First Nations communities by finding ways to enhance benefits and minimize impacts from boom-bust dynamics. Two socio-economic surveys were conducted with the Kitsumkalum First Nation, which is one of the Tsimshian Tribes potentially affected by LNG developments. Additionally, 31 interviews were conducted with LNG, mining, government, economic development and First Nations representatives, from which common themes were identified and ranked. Results showed that although high school graduation rates (16% to 34%), university education rates (4.5% to 7.3%), and unemployment rates, (29.2% to 17.2%) have improved for on-reserve Kitsumkalum members between 2006 and 2016, many continue to struggle economically. Education, training and employment (ETE) was collectively ranked by all interviewed sectors as the most important for First Nations to move towards a sustainable future, while all sectors individually ranked ETE as No. 1, except for First Nations, who ranked the removal of social barriers as No. 1 and ETE as No. 2. The need for good governance to roadmap effective changes was ranked No. 2, while the need to remove social barriers was ranked No. 3 by all sectors. In light of these results, a new framework was proposed, which incorporates the need for community characterization, a strategic sustainable development plan, good governance, and improved shared decision making and partnerships, in order to better facilitate sustainable development of Indigenous communities within the context of large-scale resource developments.Applied Science, Faculty of
Mining Engineering, Keevil Institute of
Graduate
46
He, Xinjun 1982. "Microregulation of zebrafish skeletal development by microRNAs". Thesis, University of Oregon, 2010. http://hdl.handle.net/1794/11187.
Testo completoAbstract (sommario):
xvii, 125 p. : ill. (some col.) A print copy of this thesis is available through the UO Libraries. Search the library catalog for the location and call number.MicroRNAs are small regulatory RNAs that control various developmental and physiological processes in animals and plants. To study the involvement of microRNAs in skeletal development, I manipulated the expression of miR-140, which is strongly expressed in the developing skeleton, and miR-196, which is located among the body patterning Hox cluster genes. I found that miR-140 regulates zebrafish palate formation by interfering with neural crest cell migration through the inhibition of the expression of the platelet derived growth factor receptor alpha ( pdgfra ) gene. I also found that miR196 regulates zebrafish pectoral fin initiation by regulating the expression of the retinoic acid receptor alpha b ( rarab ) gene and that miR-196 is involved in the patterning of zebrafish pharyngeal arches and vertebrae. These results illuminate previously unknown regulatory mechanisms of skeletal development. I also reviewed current knowledge concerning microRNAs in skeletal development and evolution and discussed potential relationships between microRNAs and skeletal disease. This dissertation includes previously published and unpublished coauthored material.
Committee in charge: Judith Eisen, Chairperson, Biology; John Postlethwait, Advisor, Biology; Charles Kimmel, Member, Biology; William Cresko, Member, Biology; J. Andrew Berglund, Outside Member, Chemistry
47
Eichas, Kyle Robert. "An Investigation of Multiple Pathways of Developmental Intervention Change". FIU Digital Commons, 2010. http://digitalcommons.fiu.edu/etd/239.
Testo completoAbstract (sommario):
Convergence among treatment, prevention, and developmental intervention approaches has led to the recognition of the need for evaluation models and research designs that employ a full range of evaluation information to provide an empirical basis for enhancing the efficiency, efficacy, and effectiveness of prevention and positive development interventions. This study reports an investigation of a positive youth development program using an Outcome Mediation Cascade (OMC) evaluation model, an integrated model for evaluating the empirical intersection between intervention and developmental processes. The Changing Lives Program (CLP) is a community supported positive youth development intervention implemented in a practice setting as a selective/indicated program for multi-ethnic, multi-problem at risk youth in urban alternative high schools. This study used a Relational Data Analysis integration of quantitative and qualitative data analysis strategies, including the use of both fixed and free response measures and a structural equation modeling approach, to construct and evaluate the hypothesized OMC model. Findings indicated that the hypothesized model fit the data (χ2 (7) = 6.991, p = .43; RMSEA = .00; CFI = 1.00; WRMR = .459). Findings also provided preliminary evidence consistent with the hypothesis that in addition to having effects on targeted positive outcomes, PYD interventions are likely to have progressive cascading effects on untargeted problem outcomes that operate through effects on positive outcomes. Furthermore, the general pattern of findings suggested the need to use methods capable of capturing both quantitative and qualitative change in order to increase the likelihood of identifying more complete theory informed empirically supported models of developmental intervention change processes.
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Garrigue, Marie. "Leader Developmental Readiness of Generation Y in the Training Industry". Thesis, University of North Texas, 2012. https://digital.library.unt.edu/ark:/67531/metadc271816/.
Testo completoAbstract (sommario):
Members of Generation Y in the training and development industry will be required to assume leadership roles as Baby Boomers retire, yet little empirical research exists regarding how best to prepare them for leadership. The purpose of this study was to examine differences in leader developmental readiness between generational cohorts in the training industry, specifically Baby Boomers, Generation X, and Generation Y. Leader developmental readiness provided a definition of developmental readiness for leaders using the five constructs (learning goal orientation, developmental efficacy, self-awareness, leader complexity, and metacognitive ability). A volunteer sample was compiled from members of the ASTD National LinkedIN group (n = 636). Results were analyzed using structured means analysis with maximum likelihood (ML) estimation. Generational cohorts demonstrated differences in leader developmental readiness. Baby Boomers indicated statistically and practically higher metacognitive ability and developmental efficacy than Generation Y. Results demonstrated statistically and practically higher leader complexity in Generation Y and both Generation X and Baby Boomers. These results should inform leader development practitioners as they continue to use existing methods in preparing the different generations for leader development interventions while pointing to possible needs to increase the metacognitive ability and developmental efficacy in Generation Y and ensure accurate perception of leader complexity in those individuals. Further research would be helpful to confirm or refute findings and expand on the target population for enhanced generalizability.
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Khalid, Ashiq Hussain. "Development of phosphor thermometry systems for use in development gas turbine engines". Thesis, University of Manchester, 2011. https://www.research.manchester.ac.uk/portal/en/theses/development-of-phosphor-thermometry-systems-for-use-in-development-gas-turbine-engines(f01316f9-4622-4a6d-b2d0-611a9191b5eb).html.
Testo completoAbstract (sommario):
The pursuit for improved engine efficiency is driving the demand for accurate temperature measurement inside turbine engines. Accurate measurement can allow engines to be operated closer to their design limits to improve thermal efficiency. It can enable engineers to verify mechanical integrity, provide better prediction of component life, validate CFD and other design tools and aid the development for leaner more efficient engines. Unfortunately, experimentally measuring surface temperatures under harsh rotating conditions is challenging. This EngD study conducted by Ashiq Hussain Khalid at the University of Manchester and Rolls-Royce plc, reviews the rationale of using phosphor thermometry over existing methods, including thermocouples, pyrometry and thermal paints/melts, which lack detail, accuracy, or are too expensive for continuous testing. Although phosphor thermometry exhibits desirable characteristics, the high temperature and fast rotating engine environment presents some challenges that would need to be addressed before a successful measurement system can be implemented. Examples of such issues include: rising blackbody radiation, restricted optical access, fibre optic constraints and limited time period to collect data. These factors will impose measurement limits and greatly influence the design philosophy of the system, including phosphor choice, phosphor lifetime characteristics, bonding technique, excitation/detection methodologies and probe design. Taking these into consideration, the research focuses on the development of phosphor thermometry systems for use in development gas turbine engines, with measurement solutions for specific engine components. The high pressure turbine blade was given research priority. A number of phosphors including YAG:Tb, YAG:Tm. Y2O3:Eu and Mg3F2GeO4:Mn were investigated and characterised in terms of intensity and lifetime decay, with increasing temperature up to 1500oC. Spectral analysis and absolute intensity measurements established emission peaks and permitted comparative quantitative analysis to optimise system setup. The intensity of phosphor emission relative to Planck's blackbody radiation was also performed. YAG:Tm under 355nm illumination was found to exhibit the highest emission intensity at high temperatures, and because its spectral emission peak at 458nm was the lowest, its advantage in terms of blackbody radiation was further amplified. For rotating components, an upper temperature limit is reached based on the emission intensity at rising blackbody radiation levels and the system's ability to detect fast decays. A lower limit is reached based on the quenching temperature, probe design and rotational velocity. There are different methods to correct the distorted decay waveform as it traverses through the acceptance cone of the fibre. A phosphor selection criterion, taking into consideration these limitations, was successfully applied for various rotating engine components. The optical layout was setup and tested on stationary and rotating cases under laboratory conditions using similar design constraints, including fibre choice, maximum permissible lens size and target distances. A series of tests validated design methodologies and assumptions to enable testing on full scale rotating engine components. Mg3F2GeO4:Mn, using 355nm illumination, was found to be the most suitable phosphor for the HP drive cone. The estimated performance under the expected rotational speeds was found to be 624-812°C with a standard uncertainty of ±0.99%. YAG:Tm, illuminated with 355nm, was found to be the most promising phosphor for high pressure turbine blade measurements. The performance under the expected rotational speeds was found to be 1117-1375°C with a standard uncertainty of ±0.97%. This is better than other competing technologies that are currently available for temperature measurement of rotating turbine blades.
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Svirko, Elena. "Individual differences in complex grammar acquisition : causes and consequences". Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:b0b039d2-5025-4f48-8aa5-546b6bd29090.
Testo completoAbstract (sommario):
A longitudinal study lasting 3.5 years was conducted to investigate complex grammar development, focusing on acquisition of the passive and type 3 conditionals, and its relationship with a number of domain-general, domain-specific and environmental factors. 128 children (M = 5 years 10 months) were tested at the beginning and towards the end of each school year starting from Year 1. The administered measures included established tests of fluid intelligence, short-term and working memory, seriation, grammar, vocabulary, literacy and arithmetic, plus newly-developed tests of passive and conditional sentence acquisition, and arithmetic word problem solving. It was demonstrated that grammar acquisition is not complete even when children start Year 4 of primary school (M = 8 years 7 months), when the current study was completed. At that time, 32% of children have not acquired type 3 conditionals and 89% showed no understanding of centre-embedded sentences. However, only 3% showed no passive sentence acquisition. Fluid intelligence, verbal STM and WM, ability to seriate, vocabulary and parental education level were all found to contribute to individual differences in complex grammar acquisition, independently of age differences and, where relevant, independently of non-verbal ability. There were differences between the passives and the conditionals in their relationship to these variables. Complex grammar development was found to be a significant predictor of reading comprehension, spelling and arithmetic performance, independently of age, non-verbal ability, verbal STM and WM. The findings demonstrate the inter-relatedness of higher cognitive functions, particularly domain-general with domain-specific ones. Modularity in its strictest sense (informational encapsulation, functional isolation) is not present in normally developing brains. Educational applications of the results are discussed.