Letteratura scientifica selezionata sul tema "Désordres liées aux lipides"
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Articoli di riviste sul tema "Désordres liées aux lipides":
Blandin, Alexia, e Soazig Le Lay. "Vésicules extracellulaires et maladies métaboliques". médecine/sciences 37, n. 12 (dicembre 2021): 1125–32. http://dx.doi.org/10.1051/medsci/2021209.
PEREZ, J. M. "Prévision de l’energie digestible des aliments pour le porc : intérêt du dosage des parois végétales par voie enzymatique". INRAE Productions Animales 3, n. 3 (3 luglio 1990): 171–79. http://dx.doi.org/10.20870/productions-animales.1990.3.3.4371.
FRIGGENS, N. C., D. SAUVANT e O. MARTIN. "Vers des définitions opérationnelles de la robustesse s’appuyant sur des faits biologiques. L’exemple de la nutrition." INRAE Productions Animales 23, n. 1 (8 febbraio 2010): 43–52. http://dx.doi.org/10.20870/productions-animales.2010.23.1.3284.
RENAND, G., C. LARZUL, E. LE BIHAN-DUVAL e P. LE ROY. "L’amélioration génétique de la qualité de la viande dans les différentes espèces : situation actuelle et perspectives à court et moyen terme". INRAE Productions Animales 16, n. 3 (10 maggio 2003): 159–73. http://dx.doi.org/10.20870/productions-animales.2003.16.3.3657.
BAUCHART, D., Françoise LEGAY-CARMIER, Christiane LEGAY, Sylvie TOILLON, Françoise DUBOISSET e Marinett MARTINAUD. "Effets de la prise du repas et de la teneur en lipides du régime sur la quantité de bactéries libres et liées aux particules du contenu de rumen chez la vache laitière". Reproduction Nutrition Développement 28, n. 1 (1988): 139–40. http://dx.doi.org/10.1051/rnd:19880132.
DOURMAD, Jean-Yves, Thomas GUILBAUD, Muriel TICHIT † e Thierry BONAUDO. "Les productions animales dans la bioéconomie". INRA Productions Animales, 13 maggio 2019, 205–20. http://dx.doi.org/10.20870/productions-animales.2019.32.2.2485.
CHIBOUT, Karim, e Martial MARTIN. "Entre le récit pour les masses et le mythe d’Internet, les croyances sur les réseaux sociaux comme jeu de co-constructions". Recherches en Communication 38 (10 luglio 2013). http://dx.doi.org/10.14428/rec.v38i38.50263.
Tesi sul tema "Désordres liées aux lipides":
Kuznetcova, Daria. "Development and characterization of chia (Salvia hispanica L.) plant-derived products as natural bioactive compounds". Electronic Thesis or Diss., Université de Lorraine, 2020. http://www.theses.fr/2020LORR0266.
Omega-3 polyunsaturated fatty acids (PUFA) are important for nutrition and health, by virtue of their importance in lipid homeostasis, and the fact that PUFA deficiencies can increase risk of metabolic syndrome, cardiovascular and neurodegenerative diseases. Chia (Salvia hispanica L.) seeds are rich in PUFA (80%) and contain the highest known levels in plants of the essential omega-3 fatty acid, alpha-linolenic acid (ALA). High degree of unsaturation in edible oils can reduce oxidative stability causing a loss of nutritional value. Nanotechnology can be used to improve chia seed oil quality and safety, increase bioavailability, and expand the scope of applications. Towards this goal, our objective was to prepare and characterize chia seed lipids in the form of nanoliposomes (NL) and nanoemulsions (NE), and to evaluate their potential use as bioactive products. The first step was to characterize lipid fractions. Lipids were extracted from the French ORURO variety of chia seeds using modified Folch method. Ten fatty acid species and six phospholipid (PL) classes were identified in chia seed lipid extract by gas chromatography and LC-MS, respectively, with the highest level of fatty acids being ALA (62%). The presence of a solid residue was detected following evaporation of the solvent to obtain chia seed oil. Analyses by thin layer chromatography and LC-MS demonstrated that this residue contained the polar lipids including PL that were no longer in the chia oil after removal of solvent by evaporation. NE were prepared from chia seed oil and the chia PL-rich solid residue, and NL from the PL-rich solid residue. Physicochemical characterization including analysis of the polydispersity index (PDI), size, and zeta-potential indicated that both NE and NL were monodispersed solutions of stable (low negative zeta potential) particles with a size between 104-118 nm. These preparations were spherical and multilayered (transmission electron microscopy) and remained stable even 5 days after preparation. In addition, enzymatic assay confirmed PL content in both NE and NL. MTT cell viability assay showed little to no cell toxicity (up to 150 µg/mL NE or NL) following 24 h incubation with cultured hepatocytes, neurons, and astrocytes. In conclusion, these results demonstrate the feasibility of using chia lipids for the preparation of stable non-toxic omega-3 PUFA rich NL and NE, which represent potential bioactive vectors for both preventive and therapeutic applications in human health
Vigier, Maxime. "Influence des lipides membranaires sur les interactions protéiques liées aux anomalies endolysosomales dans un modèle neuronal de la maladie d'Alzheimer". Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0331.
Alzheimer's disease (AD) is a complex and multifactorial pathology for which there is no current treatment. Several hypotheses have been proposed to explain the onset and progression of this disease, including the amyloid cascade, which predominates the field of research for the past 30 years. The amyloidogenic pathway requires the endocytosis of the APP protein in early endosomes where it undergoes two proteolytic cleavages, first by β-secretase to produce the C99 fragment, and then by γ-secretase to produce the Aβ peptide. One of the current hypotheses is that abnormalities of endocytosis and dysfunction of the endolysosomal system in neurons would constitute one of the early neuropathological mechanisms of AD, well before the neurotoxic cascade generated by Aβ and amyloid deposits. We advocate the hypothesis that changes in membrane organization, particularly during aging or due to lipid imbalances, may exacerbate or promote these dysfunctions. For this study, we used a human neuroblastoma model overexpressing the mutant protein APPswe. We first verified the presence of typical AD endolysosomal abnormalities (enlarged endosomes, blocked vesicular trafficking), to which we also associated low exosome production, chronic stress conditions that we correlated with neuronal death. Initially incriminating continuously produced Aβ in these cells, we sought to reduce its impact by inhibiting γ-secretase activity. This did not ameliorate the stress, but instead aggravated it, leading us to consider that it is the C99 fragment of APP, i.e. the substrate of Aβ production, that is the central amyloid product in the neurotoxic cascade seen in APP-overexpressing cells. The deleterious effects of C99 must occur before those of Aβ, explaining the known precocity of endolysosomal alterations. Accumulating as a result of γ-secretase inhibition, the C99 fragment interacts further with the early endosome-specific Rab5 protein. Maturation of the latter is thus prevented, blocking vesicular trafficking of the endolysosomal system. As the interactions between C99 and Rab5 occur at the membrane level of endosomes, we have modified the lipid composition of the bilayer and explored the consequences on these interactions. For this purpose, we treated SH-SY5Y-APPswe cells with docosahexaenoic acid (DHA, C22:6 n-3), the major polyunsaturated fatty acid in neuronal membranes and known for its neuroprotective properties against Aβ toxicity and AD. The expected beneficial effect on neuronal survival was indeed observed, in parallel with the unblocking of endolysosomal trafficking and exosomal production. All these changes were correlated with a dispersion between C99 and Rab5 in the membrane, suggesting that DHA treatment may initiate membrane remodeling. This remodeling may lead to protein relocalization, whereby endosomes may exchange Rab5 for Rab7 to evolve into late endosomes, thereby overcoming the initial blockage. To our knowledge, this is the first evidence that DHA can correct a phenotype directly related to AD, but its ability to remodel the neuronal membrane was previously demonstrated by our team to preserve the neurotrophic CNTF signaling in the brain of aged mice. We do not know what mechanistic principles might govern these beneficial effects, which are certainly non-specific, but we assume that by preserving the organization of the membranes of aged or chronically stressed neurons, they may prevent or restore some of the damage suffered, increase the chances of neuronal survival and thus slow AD development