Tesi sul tema "Dental resins Testing"

Orientador: Lourenço Correr Sobrinho
Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
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Resumo: Ensaios mecânicos laboratoriais são essenciais no estudo e desenvolvimento dos materiais odontológicos restauradores, como forma de predizer o comportamento clínico dos mesmos frente às variadas condições existentes no meio oral. Apesar das condições encontradas in vivo dificilmente serem inteiramente representadas in vitro, o completo entendimento dos fatores que impactam o protocolo dos testes é determinante na análise dos resultados. Entretanto, muitos dos testes utilizados para caracterização dos materiais restauradores não são realizados nos padrões necessários, levando a resultados ambíguos para materiais similares, além de dificultar a comparação implementação dos mesmos. O objetivo deste estudo foi avaliar o efeito de diferentes parâmetros empregados em ensaios mecânicos utilizados no teste de materiais odontológicos restauradores para obtenção de propriedades mecânicas ou verificação da resistência de união. Assim, variadas configurações do ensaio de flexão de três pontos e do teste de microcisalhamento foram analisadas de maneira crítica. Pode-se concluir que as modalidades de ensaios mecânicos testadas necessitam de melhor padronização para que os resultados obtidos apresentem menor discrepância e consequentemente maiores representatividade clínicos. A maior padronização dos ensaios mecânicos utilizados na caracterização dos materiais odontológicos permite melhor compreensão do comportamento mecânico dos mesmos, levando a um desenvolvimento mais controlado destes produtos, o que por sua vez, resultará em maior qualidade dos procedimentos reabilitadores
Abstract: Mechanical tests are essential for the study and development of restorative materials and to predict their clinical behavior facing the numerous conditions existing at the oral environment. Despite the situations found in vivo are hardly represented completely in vitro, the full comprehension of the factors that can affect the testing protocols is important for the analysis of laboratory assays. However, most of the tests used for characterizing restorative materials are not performed in the adequate manner, leading to ambiguous results for similar materials and challenging comparisons between materials, besides impairing their improvement. On this way, the present study aimed to evaluate the influence of different testing parameters employed in mechanical tests for obtaining the mechanical properties of dental materials or to check their bond strength. Thus, different three-point bending and microshear designs were evaluated. It was concluded that the mechanical testing modalities studied need better standardization in order to produce results with minimized discrepancies and consequently increased clinical importance. Well standardized mechanical tests for dental materials testing provide better understanding of their mechanical behavior, allowing more controlled development of these products and resulting in an increased quality for rehabilitative procedures
Doutorado
Materiais Dentarios
Doutor em Materiais Dentários

El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
PURPOSE: To evaluate the effect of aqueous solutions of chlorhexidine digluconate (CHX) in different concentrations on bond strength to eroded dentin up to 6 months, using normal dentin as a control. METHODS: Exposed flat dentin of extracted third molars was only ground with 600-grit SiC paper/1 minute (normal dentin - N), or subsequently eroded by a regular-cola soft-drink (eroded dentin - E). N and E were acid-etched, washed, dried and rehydrated with 1.5 μL, respectively, of distillated water (control - NC / EC); of 0.004% CHX (N0.004% / E0.004%); or of 2% CHX (N2% / E2%). Adper Single Bond 2 was applied in all specimens and resin composite buildups were constructed with Filtek Z350. Specimens were sectioned in beams, which were tested (μTBS) immediately or after 6 months of aging. RESULTS: Microtensile bond strength to eroded dentin was always significantly lower than that to normal dentin. Application of tested CHX solutions did not exert a significant effect immediately; however, after aging, the 2% CHX prevented abrupt bond strength loss both to eroded and normal dentin.
Revisión por pares

The field of restorative dentistry and the problem of ultrasonic airframe corrosion in aerospace are introduced as motivation for the construction of a miniature ultrasonic pulser/receiver.
A broadly applicable ultrasonic pulser and receiver system is developed. Two pulsers, a 5V square and a 100V spike, and a 52dB amplifier with a 57MHz 6dB bandwidth were constructed as a result. These battery powered devices are tailored for compatibility with a custom built wireless data transmission system, also driven by the same voltage. It is demonstrated that the new pulser/receiver is comparable to the commercial system in performance in certain areas.
The new pulsers/receiver and a commercial one are used in this work. The data is acquired and analyzed using LabView and Matlab. It is shown that the ultrasonic technique can be used to follow the reaction in time as well as to gauge the cure of dental composites. The current work in ultrasonic airframe corrosion detection is furthered and the wireless system's functionality is affirmed.

The invention of dental resin based-composites (RBCs) has provided a broad range of materials for the restoration of load-bearing posterior teeth with excellent clinical results and adequate longevity. Currently, a lack of consensus exists among researchers regarding classification of RBCs as a result of slight variations in filler size and associated interchangeable mechanical properties of “microhybrid”, “nanohybrid” and “nanofilled” RBCs. Also, the inconsistency in mechanical property testing of RBCs is evident amongst researchers. This research explored the variability in experimental and statistical testing methodologies of RBCs. The current study identified a wide variation in the bi-axial flexure strength (BFS) of commercial and experimental RBCs with respect to deformation rate with a complex relationship between resin constituents and filler morphology. Experimental unfilled resins revealed deformation rate dependence in BFS following 1 week dry, 1 and 13 weeks wet storage regimes, whereas the addition of fillers modified the deformation rate dependence following 13 weeks wet storage and resulted in the BFS of filled resin composites being independent of testing speed. These findings suggested the need for the development of RBCs with appropriate formulations for clinical situations where variable strain rates may occur, for example, patients with parafunctional habits. To date, the alignment of specimens during storage regimes prior to mechanical property testing has rarely been reported. The effect of specimen alignment on the BFS and surface hardness of RBCs was evaluated and a greater decrease in the both properties were found following wet upright compared with stacked and upper surface exposed alignments. These observations were attributed to a variation in diffusion of water as the result of difference in exposed surface areas of specimens, which may lead to different findings and associated interpretation between investigators. Weibull statistics are used for the analysis of strength data of RBCs, however their applicability to RBCs might be questioned due to some viscous deformation prior to brittle failure. The findings of current study supported the applicability of Weibull statistics for the microhybrid and nanofilled RBCs but not a flowable RBC, which suggested that Weibull statistics may not necessarily be applicable for all RBC types. It was demonstrated that variability and irrelevance in testing methods may cause incorrect interpretation of data among researchers and consequently affect the future research and development of RBCs. Therefore, further standardisation of testing methods is required.

Uobičajeni pristup i testiranju biološkog ponašanja materijala je da se počne sa jednostavnim in vitro testovima baziranim na ćelijskim kulturama. In vitro testovi citotoksičnosti su danas jedan od osnovnih načina za procenu biološkog odgovora na materijal jer su brži, lakši za ponavljanje, ocenjivanje i jeftiniji u odnosu na eksperimente koji se izvode na životinjama i ljudima. Koriste se kao neka vrsta skrining testova za procenu biološke sigurnosti materijala. Za razliku od ćelijskih kultura, istraživanja koja uključuju eksperimentalne životinje pružaju bolji uvid u biokompatibilnost materijala, zbog mogućnosti praćenja kompleksnog imunološkog odgovora živog organizma. Smatraju se neophodnim za ocenu biloških odgovora na novi materijal, pre nego što se on upotrebi na ljudima. Mnogi aspekti biološkog odgovora ne mogu biti reprodukovani in vitro testovima uključujući krvne interakcije, zarastanje rana, reakcije preosetljivosti, karcinogenezu, hroničnu inflamaciju. Eksperimenti na životinjama pružaju informacije o ovim tipovima efekata bez izlaganja ljudi riziku. Cilj ovog istraživanja bio je da se oceni biokompatibilnost objekata od polimera na bazi epoksi smole Accura® ClearVue™ (hemijski sastav: 4,4’- izopropilidendicikloheksanol, produkti oligomerne reakcije sa 1-hlor-2,3- epoksipropanom(40-65%), smešа triaril-sulfonijum soli (50% propilen-karbonata i 50% triaril-sulfonijum heksafluoroantimonatnih soli) (1-10%) i 3-etil-3hidroksimetil-oksetan(10-20%). U oceni citotoksičnosti materijala Accura® ClearVue™ korišćeni su agar diguzioni i MTT test. Oba testa rađena sun a ćelijskim kulturama L929 (mišiji fibroblasti) i MRC-5 (humani fibroblasti). Ocena biokompatibilnosti testiranog materijala vršena je na osnovu urađenog testa iritacije oralne mukoze na modelu bukalne kesice hrčka, što je definisano standardom ISO 10993-10:2010. Biokompatibilnost materijala ispitana je i implantacijom uzoraka u potkožno tkivo dorzuma pacova soja Wistar.
Uobičajeni pristup i testiranju biološkog ponašanja materijala je da se počne sa jednostavnim in vitro testovima baziranim na ćelijskim kulturama. In vitro testovi citotoksičnosti su danas jedan od osnovnih načina za procenu biološkog odgovora na materijal jer su brži, lakši za ponavljanje, ocenjivanje i jeftiniji u odnosu na eksperimente koji se izvode na životinjama i ljudima. Koriste se kao neka vrsta skrining testova za procenu biološke sigurnosti materijala. Za razliku od ćelijskih kultura, istraživanja koja uključuju eksperimentalne životinje pružaju bolji uvid u biokompatibilnost materijala, zbog mogućnosti praćenja kompleksnog imunološkog odgovora živog organizma. Smatraju se neophodnim za ocenu biloških odgovora na novi materijal, pre nego što se on upotrebi na ljudima. Mnogi aspekti biološkog odgovora ne mogu biti reprodukovani in vitro testovima uključujući krvne interakcije, zarastanje rana, reakcije preosetljivosti, karcinogenezu, hroničnu inflamaciju. Eksperimenti na životinjama pružaju informacije o ovim tipovima efekata bez izlaganja ljudi riziku. Cilj ovog istraživanja bio je da se oceni biokompatibilnost objekata od polimera na bazi epoksi smole Accura® ClearVue™ (hemijski sastav: 4,4’- izopropilidendicikloheksanol, produkti oligomerne reakcije sa 1-hlor-2,3- epoksipropanom(40-65%), smeša triaril-sulfonijum soli (50% propilen-karbonata i 50% triaril-sulfonijum heksafluoroantimonatnih soli) (1-10%) i 3-etil-3hidroksimetil-oksetan(10-20%). U oceni citotoksičnosti materijala Accura® ClearVue™ korišćeni su agar diguzioni i MTT test. Oba testa rađena sun a ćelijskim kulturama L929 (mišiji fibroblasti) i MRC-5 (humani fibroblasti). Ocena biokompatibilnosti testiranog materijala vršena je na osnovu urađenog testa iritacije oralne mukoze na modelu bukalne kesice hrčka, što je definisano standardom ISO 10993-10:2010. Biokompatibilnost materijala ispitana je i implantacijom uzoraka u potkožno tkivo dorzuma pacova soja Wistar.
The usual approach in testing biological behavior of materials is to start with simple in vitro tests based on cell cultures. In vitro cytotoxicity tests are one of the basic methods of assessing the biological response to material because they are faster, cheaper, easier for repeating and evaluating compared to experiments carried out on animals and humans. They are used as a kind of screening test for evaluating the biosafety of materials. Unlike cell culture, studies involving experimental animals provide better insight into the biocompatibility of materials due to the possibility of monitoring the complex immune response of a living organism. They are considered necessary for assessing the biological response to new material before it is used on humans. Many aspects of a biological response cannot be reproduced with in vitro tests, including blood interaction, wound healing, hypersensitivity reactions, carcinogenesis, chronic inflammation. Animal experiments provide information about these types of effects without exposing humans to risk.  The aim of this study was to evaluate the biocompatibility of polymer objects on the basis of epoxy resins Accura® ClearVue ™ (chemical composition: 4.4' Isopropylidenedicyclohexanol, oligomeric reaction products with 1-chloro-2.3-epoxypropane (40-65%), a mixture of triaryl sulfonium salt (50% propylene carbonate and 50% of a triarylsulfonium hexafluoroantimonate salt) (1- 10%) and 3-ethyl-3-hydroxymethyl-oxetane (10-20%). In the assessment of the cytotoxicity of materials Accura® ClearVue ™ agar diffusion and MTT tests were used. Both tests were conducted on cell cultures L929 (mouse fibroblasts) and MRC-5 (human fibroblasts). An assessment of the biocompatibility of the tested material was done on the basis of an oral mucosa irritation test on a hamster cheek pouch as defined by ISO 10993-10: 2010. The biocompatibility of the material was also tested with the implantation of a samples into the dorsal subcutaneous tissue of a Wistar rats. The subcutaneous implantation test, as one of the most reliable methods for assessing the biocompatibility of dental materials, is defined by ISO 10993-6: 2010. The study was conducted on 30 rats which were sacrificed in groups

La littérature scientifique révèle que les résultats in vitro sur les matériaux dentaires ont une faible corrélation avec le comportement clinique. Les tests standardisés aux normes fournissent des informations précieuses et pertinentes sur les propriétés des matériaux dentaires, et permettent aussi de comparer les résultats de différents instituts. Cependant, le développement de nouveaux matériaux à partir de nouvelles formulations chimiques nécessite une amélioration des méthodes d'évaluation. Ce travail de recherche est réalisé dans le but d'approfondir les connaissances sur les méthodes d'évaluation des matériaux dentaires avant insertion dans la cavité buccale. Une grande importance a été donnée au choix des matériaux à tester ; nous nous sommes basés sur les dernières tendances actuelles et les derniers développements de composition de matériaux dentaires. La même importance a été donnée à des méthodes et des techniques d'essai au laboratoire ; leur corrélation avec les résultats cliniques a été mise en évidence. Les modifications apportées à la méthodologie de ces tests ont exploré davantage les aspects cachés des différentes interactions de paramètres. La caractérisation et l'évaluation des matériaux dentaires nécessitaient une meilleure compréhension de l'interaction entre les différentes propriétés pour expliquer le vieillissement des matériaux. Notre travail a consisté à combiner de nombreuses études pour répondre à ce sujet. Les études ont porté sur les propriétés mécaniques et physiques, le composite fibré et Bulk, les matériaux CAM CAD, les adhésifs dentaires, le choc thermique et le cyclage thermique, le bisphénol A. L'objectif final était de développer un simulateur oral qui permettrait la reproduction de différents paramètres chimiques, physiques et mécaniques de l'environnement buccal, permettant ainsi de combler l'écart entre les tests in vitro et in vivo de matériaux dentaires
Scientific literature reveals that in vitro results are poorly correlated to materials clinical behavior. ISO standardized testing provides valuable information about the dental materials properties, and enables result comparison between different institutes. Conversely, new materials chemistry and formulations requires improved methodology and testing methods. Throughout our studies included in this work, the main objective was to reach a more global knowledge of the way dental materials are evaluated before being inserted into the oral cavity. A great deal of emphasis was given to the choice of materials to be tested, and that it would represent the current trends in dental practice and the latest developments in material composition. Equal highlight was given to the choice of testing methodology and laboratory testing techniques and their correlation to the clinical outcome. The modifications made to the methodology of these tests explored further the concealed aspects of different parameter interactions. Dental materials characterization and assessment required more understanding about the interaction between different properties to explain material aging; our work was to combine numerous studies to answer this topic. The studies included mechanical and physical properties, bulk and fiber composite, CAD CAM block materials, dental resin adhesive, thermal shock and thermal cycling, Bisphenol A. The final objective was to develop an oral simulator that would enable the reproduction of different chemical, physical and mechanical parameters of the oral environment, thus permitting to bridge the gap between in vitro and in vivo testing of dental materials

Avaliou-se a resistência de união do pino de fibra de vidro à dentina cimentado com quatro agentes cimentantes, por meio do teste push-out realizado após 24 horas e seis meses de armazenagem. Foram selecionados 80 dentes humanos uniradiculares, tratados endodonticamente e divididos aleatoriamente em quatro grupos (n=20), variando-se o tipo de cimento utilizado: grupo I: cimento de ionômero de vidro reforçado com resina (Fuji PlusTM, GC Corp., Tokyo, Japan); grupo II: cimento resinoso usando sistema adesivo convencional de 3 passos de aplicação (RelyX ARC + Scotchbond Multi-purpose, 3M ESPE, St Paul, MN, USA); grupo III: cimento resinoso usando sistema adesivo autocondicionante de 1 passo de aplicação (PanaviaTM F, Kuraray, Osaka, Japan); e grupo IV: cimento resinoso auto-adesivo (BisCemTM, Bisco Inc., Schaumburg, IL). Cada grupo foi subdividido em dois subgrupos (N=10) variando-se o tempo de armazenagem (24 horas e seis meses). O teste de push-out foi realizado com uma velocidade de 1,0 mm/min, e os resultados expressos em Mega Pascal (MPa). Após o teste de push-out, todos os espécimes foram observados em microscópio óptico de fluorescência (40x) e analisado o tipo de falha apresentado entre o complexo pino/cimento/dentina radicular. Os valores médios de resistência (MPa) foram submetidos ao teste ANOVA a dois critérios e de Tukey (p<0,005). A análise estatística mostrou: 1) Diferenças significativas na resistência de união entre os cimentos utilizados, sendo que a média total do cimento resinoso RelyXTM ARC + ScotchbondTM MultipurposeTM foi superior aos dos outros cimentos após 24 horas; 2) A resistência de união dos cimentos resinosos RelyXTM ARC + ScotchbondTM MultipurposeTM e PanaviaTM F foram superiores aos outros cimentos quando testados após seis meses de armazenagem e não houve diferença significativa entre eles; 3) Após seis meses de armazenagem, observou-se um aumento na resistência de união de todos os cimentos; 4) Na análise por terços, foi observado que tanto após 24 horas quanto após seis meses, o terço cervical teve uma maior resistência de união do que o terço médio e apical; 5) Foram observadas predominantemente falhas mistas, apresentado-se na maioria dos casos a combinação de falha adesiva na interface pino/cimento e na interface cimento/dentina para todos os grupos. Concluiu-se que a resistência de união aumentou após seis meses de armazenagem graças possivelmente à expansão higroscópica e aumento da retenção friccional.
The bond strength of a glass fiber post luted to dentin with four luting agents was evaluated using the push-out test, after 24-hours and six months of storage. Eighty human single-routed teeth was selected, endodontically treated and randomly divided into four groups (n=20), modifying the luting agent used: group I: resin modified glass-ionomer (Fuji PlusTM, GC Corp., Tokyo, Japan); group II: resin cement using total-etch, three step adhesive system (RelyX ARC + Scotchbond Multi-purpose, 3M ESPE, St Paul, MN, USA); group III: resin cement using self-etch one step adhesive system (PanaviaTM F, Kuraray, Osaka, Japan); and group IV: self-adhesive resin cement (BisCemTM, Bisco Inc., Schaumburg, IL). Each group was, then, subdivided into two subgroups (n=10) modifying the storage period (24-hours and six months). The push-out test was performed with a cross-speed of 1,0 mm/min, and the results expressed in Mega Pascal (MPa). After the test, all specimen interfaces were examined with the aid of a fluorescence optic microscope (40x) to dertemine the type of failure at the complex post/cement/dentin. The mean values of the bond strength (MPa) were analyzed with the two-way ANOVA and Tukey test (p<0,005). The statistical analysis showed: 1) Significant difference in the bond strength between the luting agents, in wich the mean total value of the resin cement RelyXTM ARC + ScotchbondTM MultipurposeTM was the highest after 24 hours; 2) The bond strength of the resin cement RelyXTM ARC + ScotchbondTM MultipurposeTM and PanaviaTM F were higher than the others luting agents when evaluated after six months, and there was no significant difference among both of them; 3) An increase in the bond strength of all luting agents after six months of storage in distilled water; 4) That the cervical third had a higher bond strength compared to the middle and apical thirds for all materials, during third analysis after 24-hours and six months of storage; 5) Predominantly, it was observed mixed failures, in the majority of the cases, with a combination of adhesive failure in the post/luting agent interface and in the luting agent/radicular dentin interface. Therefore, can be concluded that the bond strength of a glass fiber post luted to dentin with different luting agents can increase after six months of storage, possibly contributed by hygroscopic expansion and the increase of the frictional retention.

Indiana University-Purdue University Indianapolis (IUPUI)
Indirect composites were introduced so that the composites can be cured extraorally to improve the degree of conversion and other material properties. These materials are indicated as long term full coverage dental restorative materials. However the mechanical and physical properties of new Second Generation Indirect Composites for this particular application have not been fully evaluated. The purpose of the study was to compare the appropriateness of the four commercially available laboratory composite resins for application as long term full coverage restorative materials. Water solubility and sorption levels, staining resistance, gloss, surface roughness, wear due to tooth brush abrasion, two-body and three-body wear, fracture toughness and radiopacity of four indirect composite restorative materials; Radica (Dentsply), Sculpture Plus (Pentron), Belleglass-NG (Kerr) and Gradia Indirect (GC America) were determined. The results showed that the four composites differed significantly from each other. Bell eglass-NG and Gradia Indirect showed negative water solubility. All the four groups demonstrated less color stability when exposed to coffee slurry for 3 weeks. Significant decrease in gloss and volume occurred when the omposites were exposed to simulated tooth-brush abrasion. Sculpture Plus v demonstrated lowest abrasion and attrition wear resistance among the four indirect composites. Radica had the highest fracture toughness and radiopacity of all the composites with values close to or less then dentin. In conclusion, different indirect composite systems possessed different mechanical and physical advantages when compared to each other. In general, Belleglass-NG demonstrated superior advantages due to its higher abrasion and attrition wear resistance and stain resistance. This was followed by Radica,Gradia Indirect and Sculpture Plus.

Indiana University-Purdue University Indianapolis (IUPUI)
Both quaternary ammonium bromide (QAB) and furanone derivatives were synthesized, characterized and formulated into dental resin composites for improved antibacterial properties. Compressive strength (CS) and S. mutans viability were used to evaluate the mechanical strength and antibacterial activity of the restoratives. The effects of chain length, loading, saliva and aging on CS and S. mutans viability were investigated. Chapter 2 describes how we studied and evaluated the formulated antibacterial resin composites by incorporating the synthesized QAB-containing oligomers into the formulation. The results show that all the QAB-modified resin composites showed significant antibacterial activity and mechanical strength reduction. Increasing chain length and loading significantly enhanced the antibacterial activity but dramatically reduced the CS as well. The 30-day aging study showed that the incorporation of the QAB accelerated the degradation of the composite, suggesting that the QAB may not be well suitable for development of antibacterial dental resin composites or at least the QAB loading should be well controlled. Chapter 3 describes how we studied and evaluated the formulated antibacterial resin composite by incorporating the synthesized furanone derivative into the formulation. The results show that the modified resin composites showed a significant antibacterial activity without substantially decreasing the mechanical strengths. With 5 to 30% addition of the furanone derivative, the composite kept its original CS unchanged but showed a significant antibacterial activity with a 16-68% reduction in the S. mutans viability. Further, the antibacterial function of the new composite was found not to be affected by human saliva. The aging study indicates that the composite may have a long-lasting antibacterial function. In summary, we have developed a novel QAB- and furanone-containing antibacterial system for dental restoratives. Both QAB- and furanone-modified resin composites have demonstrated significant antibacterial activities. The QAS-modified experimental resin composite may not be well suitable for development of antibacterial dental resin composites due to its accelerated degradation in water unless the QAB loading is well controlled. The furanone-modified resin composite shows nearly no reduction in mechanical strength after incorporation of the antibacterial furanone derivative. It appears that the furanone-modified resin composite is a clinically attractive dental restorative that can be potentially used for long-lasting restorations due to its high mechanical strength and permanent antibacterial function.

Indiana University-Purdue University Indianapolis (IUPUI)
Objective: CAD/CAM technology allows fabrication of thin lithium disilicate (LD) veneers to a LD crown substructure in place of using traditional feldspathic porcelain (FP) which has inferior mechanical properties. This project investigated the effect of different LD veneer applications to LD substructure on the biaxial flexural fatigue of LD veneer/substructure restorations. Materials/Methods: Forty-five LD discs (Ø = 120.7 mm) were fabricated that, when combined with the veneering discs, achieve final dimensions of (Ø = 121.2mm). Experimental groups were (n = 15) as follows: (1) Resin Bonded LD Veneer (RBLDV), LD veneer (Ø = 120.5 mm) adhesively cemented to LD (0.7 mm); (2) Sintered LD Veneer (SLDV), LD veneer (Ø=120.5 mm) sintered to LD (0.7 mm); (3) Sintered Feldspathic Veneer (SFV), feldspathic porcelain (FP) applied to LD discs to achieve a final dimension of (Ø = 121.2 mm). A fourth group of (1.2 mm) monolithic LD served as the control. Weibull-distribution survival analysis was used to compare the differences of the resistance to fracture after fatigue between groups. Total number of cycles were analyzed using one-way Anova (p < 0.05). Hypothesis: Adhering or sintering a thin laminate layer of LD on another LD surface would result in increased fracture resistance in comparison to sintered FP on LD. Results: The SFV group had significantly lower fatigue resistance than SLDV and RBLDV groups (p < 0.05). The RBLDV group fractures resulted in significantly more fractured fragments in comparison to the other groups. No statistical difference was observed in the number of cycles. The results also showed that the LD veneered groups presented similar resistance to fatigue as monolithic discs of the same overall dimensions. Conclusion: The hypothesis was accepted suggesting that veneering a LD substructure with a LD veneer, bonded or sintered, has increased resistance to fatigue as FP veneering material on a LD substructure. In addition, it was observed to have similar resistance to fatigue in comparison to the monolithic LD group.