Articoli di riviste sul tema "Darwin (N.T)"

1 Department of Microbiology, The Royal Women's Hospital, Victoria, 2 Menzies School of Health Research, Rocklands Drive, Tiwi, 3 Department of Epidemiology and Preventive Medicine, Alfred Hospital, Monash University, Prahran, Victoria and 4 AIDS/STD Unit, Centre for Disease Control, Territory Health Services, Darwin, Australia Summary: Self-administered sampling techniques for the detection of sexually transmitted diseases (STDs) are particularly useful due to their ease of collection and better patient compliance. Urine specimens, and recently tampons, have been described as methods of specimen collection for the detection of some STDs in women. In this study, 660 women had both first-void urine (FVU) and tampon specimens analysed by polymerase chain reaction (PCR) for the detection of Chlamydia trachomatis , Neisseria gonorrhoeae and Trichomonas vaginalis . Overall 6.5%, 10.1% and 17.9% of urine samples were positive whereas 7%, 21.2% and 22% of tampon specimens were positive for C. trachomatis , N. gonorrhoeae and T. vaginalis respectively. Tampon-collected specimens tested by PCR were more sensitive than urine specimens for the detection of N. gonorrhoeae and T. vaginalis ( P 0.001) and equally sensitive for the detection of C. trachomatis ( P =0.45). <

During 1959-89, the 12-month running means of 50 hPa zonal winds, the average atmospheric temperatures in the northern and southern hemisphere at four altitude slabs (950 hPa, 850- 300 hPa, 300-100 hPa and 100-50 hPa), Pacific and Atlantic sea surface temperature (SST) and-30hPa temperatures at North Pole and average for (10°-90° N), all showed quasi-biennial oscillations (QBO). However, whereas the wind QBO had an average spacing of 29 months, only temperatures at 300-100 hPa and Atlantic SST had similar average spacing. Other temperatures as also SO index (represented by Tahiti minus Darwin atmospheric pressure) had larger average spacing. Spectral analysis showed that whereas wind QBO had only one prominent peak at T=2.33 years, other parameters had weak QBOs near T=2.5-2.6 years except Pacific SST and 30 hPa North Pole temperature which had small peaks near T=2.3 years. All the temperatures had prominent peaks in the 3-6 year region which matched with similar peaks in the SO index. There is some indication that stratospheric wind QBO had some relation with parameters at all altitudes in tropics and with North Pole, while ENSO had considerable influence at other latitudes/altitudes.

Megabalanus coccopoma (Darwin, 1854) is a globally invasive species in Balanomorpha (Crustacea). This species is a model organism for studying marine pollution and ecology. However, its mitogenome remains unknown. The mitogenome sequencing of M. coccopoma is completed in the present study. It has a 15,098 bp in length, including 13 protein-coding genes (PCGs), 2 ribosomal RNAs (rRNAs), 22 transfer RNAs (tRNAs), along with a putative regulatory area. A substantial A+T bias was observed in the genome composition (68.2%), along with a negative AT (0.82) and GC (−0.136) skew. Compared to the gene sequence of the ground model of pan-crustacea, 13 gene clusters (or genes), such as 10 tRNAs and 3 PCGs, were observed in a different order. This was in line with the previously observed large-scale gene rearrangements of Balanomorpha. Among the 37 genes, the gene cluster (M-nad2-W-cox1-L2-cox2-D-atp8-atp6-cox3-G- nad3-R-N-A-E-S1) Balanomorpha was conserved. Furthermore, phylogeny analysis indicated that the existing Balanomorpha species family was divided into nine rearrangement patterns, supporting the polyphyly of Balanoidea.

Abstract BACKGROUND: The low mutational burden and immunologically “cold” microenvironment of mutant IDH1 low-grade gliomas (LGG) are considerable challenges facing immunotherapy against these tumor types. However, we hypothesize that LGG-targeting T-cells may exist at low frequency and with limited regional infiltration within the tumor. Multi-region tumor sampling coupled with high-throughput T-cell receptor (TCR) profiling across the LGG landscape detected neoantigen-specific T-cells that persisted in peripheral blood. TCR-engineered T-cells transduced with these TCRs demonstrated neoantigen-specific immunogenicity. METHODS: Maximal-anatomical sampling of at least 10 distinct tumor regions were collected at the initial resection for three WHO Grade II diffuse astrocytoma patients for exome-based prediction of clonally and subclonally expressed neoantigens, RNAseq analysis of regional immune cell composition, and TCR beta deep sequencing. We used these predictions to generate a barcoded library of patient-specific peptide-HLA multimers loaded with predicted neoepitopes. With this library, neoantigen-specific CD8+ T-cells were captured and isolated from patient peripheral blood. Single cell TCR sequencing allowed us to identify the neoantigen-reactive TCR clonotypes which were transduced subsequently into Jurkat76 cell lines for functional validation. RESULTS: We screened patient-derived peripheral blood drawn two years after initial resection in 3 mutant IDH1 LGG patients and detected a total of 20 TCR clonotypes recognizing neoepitopes derived from truncal, tumor-wide mutations in CNTNAP1 (n=8), TP53 (n=3), and MRPL46 (n=2) as well as subclonal mutations in PRMT5 (n=1) and ZDHHC5 (n=6). Multi-sampling RNAseq analysis indicated varying degrees of interpatient and intratumoral immune infiltration as well as distally located populations of neoantigen-reactive T-cells within the tumor, suggesting widespread migration of neoantigen-specific T-cells across the glioma landscape. We proceeded with TCR functional analysis for one patient (P375) with 5 detected TCR clonotypes recognizing neoantigens derived from mutations in PRMT5, MRPL46, and TP53. Jurkat76 cells transduced with the mutant-PRMT5-specific TCR demonstrated a neoantigen-specific immune response when co-cultured with mutant-PRMT5 pulsed-antigen presenting cells expressing HLA-A*0201 (T2 cells). CONCLUSION: Our study demonstrates the existence and persistence of neoantigen-targeting T-cells within the blood and tumor of mutant IDH1 LGG patients. We identified a TCR clonotype that successfully recognizes and induces an immune response against mutant-PRMT5. These findings suggest a feasible methodology to develop personalized T-cell-based immunotherapies for patients with mutant IDH1 LGGs. Citation Format: Darwin W. Kwok, Michael Y. Zhang, Cliff Wang, Nicholas Stevers, Tyler Borrman, Zheng Pan, Benjamin Yuen, Songming Peng, Diana Nguyen, Michael Martin, Chibo Hong, Stephanie Hilz, Joanna Phillips, Anny Shai, Nancy Ann Oberheim Bush, Shawn Hervey-Jumper, Michael McDermott, Stefanie Mandl, Hideho Okada, Joseph Costello. Tumor-wide neoantigen-specific T-cells infiltrating mutant IDH1 low-grade gliomas and persisting in peripheral blood allow for personalized TCR-based immunotherapies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 895.

Abstract BACKGROUND: The efficacy of immunotherapy in gliomas is limited by tumor heterogeneity and low mutational burden. Recent studies revealed increased alternative splicing (AS) in various cancer types that potentially translate into targetable neoantigens. We developed a novel comprehensive in silico pipeline for detecting tumor-specific AS events (neojunctions), and successfully identified tumor-wide, public, alternatively spliced neoantigens (ASNs) that elicited CD8+ T-cell-mediated immune responses. METHODS: Our computational pipeline first identified recurring splice junctions in high purity TCGA LGG/GBM bulk RNA-seq samples (n=429, PSR &gt; 10%) and not in GTEx normal tissue bulk RNA-seq data (n=9166, PSR &lt; 1%). We subsequently employed two independent algorithms to predict the peptide processing likelihood and the HLA-binding affinity of ASN candidates before validating neojunction and ASN expression in RNA-seq data from patient-derived glioma cell lines (n=68) and spatially-mapped glioma samples (n=535), and in the Clinical Proteomic Tumor Analysis Consortium (CPTAC) GBM mass spectrometry data (n=99). In vitro sensitization of healthy donor-derived CD8+ T-cells against our top ASN candidates followed by 10x VDJ scRNA-seq was performed to identify ASN-specific TCR sequences. We transduced these TCRs into Jurkat76s and co-cultured them with ASN-pulsed T2 cells and ASN and HLA-expressing COS7 cells to determine whether the TCR recognized the presented HLA:ASN. RESULTS: Our analysis identified 249 putative neojunctions that translated into 222 cancer-specific peptides sequences. Iterating across these peptides yielded 17,562 glioma-specific n-mer sequences between 8 to 11 amino acids in length. Both prediction algorithms concurrently identified 636 n-mers likely to be presented by demographically common HLA haplotypes. Through transcriptomic and proteomic validation with patient-derived samples and cell lines, we identified 8 ASNs that were tumor-wide, 4 of which were predicted to be HLA*A0201-presented. In vitro sensitization of healthy-donor derived CD8+ T-cells against these 4 ASNs resulted in an expansion of reactive CD8+ T-cells against ASNs derived from neojunctions within S100A6, RPL22, and GNAS. Subsequent 10x VDJ scRNA-seq on the expanded CD8+ population identified mutRPL22-reactive TCR clonotypes with neoantigen-mediated increases in IFNG and GZMB signatures. When transduced and expressed in Jurkat76 cells, one particular TCR clonotype demonstrated recognition and immunogenic activation against mutRPL22-pulsed T2 cells and COS7 cells endogenously expressing both HLA*A0201 and mutRPL22. CONCLUSION: Our unique integrative pipeline detected novel tumor-wide splice-derived neoantigen candidates, and ASN-reactive TCRs identified through our pipeline offer a new avenue for TCR-based therapies across cancer types. Citation Format: Darwin W. Kwok, Takahide Nejo, Nicholas Stevers, Lee H. Chen, Kaori Okada, Chibo Hong, Gary K. Chan, Akane Yamamichi, Aidan Du, Maggie Colton, James Woo, Joseph Costello, Hideho Okada. Targetable public neoantigens are generated by tumor-wide cancer-specific splicing events in gliomas [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3152.

Abstract BACKGROUND: Immunotherapy in gliomas is limited by intratumor heterogeneity (ITH) and low mutational burden. We developed a novel comprehensive in silico pipeline for detecting tumor-specific splicing events (neojunctions), and across multiple cancer types, we successfully identified a new class of tumor-wide, public, alternatively spliced neoantigens (ASNs) that elicit CD8+ T-cell-mediated immune responses. METHODS: Our pipeline identified recurring public neojunctions expressed in TCGA RNA-seq (positive sample rate (PSR) &gt; 10%) and not in GTEx normal tissue RNA-seq data (PSR &lt; 1%) across ten cancer types. To characterize tumor-wide neojunctions, we utilized available multi-site RNA sequencing across diverse cancer types. With gliomas, our in-house dataset comprised of 56 patients with approximately 10 maximally-distanced intratumoral biopsy sites per patient (n=535). Tumor-wide public neojunction expression was subsequently validated in RNA-sequencing and mass spectrometry (MS) data from patient-derived cell lines (n=68) and samples (n=447). Two independent algorithms then predicted peptide processing likelihood and HLA-binding affinity of ASN candidates. TCRs identified by in vitro sensitization (IVS) of donor-derived CD8+ T-cells followed by 10x VDJ scRNA-seq, were transduced into CD8+ T-cells and co-cultured with tumor cells to evaluate TCR functionality and cytotoxicity. RESULTS: Pan-cancer analysis identified large subsets of neojunctions that were interpatiently and intratumorally conserved. Our glioma-specific analysis identified 789 public neojunctions, and 8 ASNs were validated in transcriptomic and proteomic glioma data and predicted to be presented by HLA-A*02:01 with high confidence. IVS and subsequent 10x VDJ scRNA-seq on expanded PBMC-derived CD8+ populations cultured against ASN-pulsed dendritic cells identified TCR clonotypes reactive against neojunctions in RPL22 (n=7) and GNAS (n=1), the latter being highly intratumorally-conserved (detected in &gt; 90% of spatially-mapped biopsies in 17/56 patients (26.78%)). TCR-transduced T-cells demonstrated recognition and immunogenic activation against endogenously processed and presented neoantigens in both pan-cancer cell lines and transfected COS7 cells and cytotoxicity against glioma cell lines. Pan-cancer analysis revealed the detection of both neojunctions in various tumor types beyond gliomas, with the GNAS neojunction notably found tumor-wide in mesothelioma, prostate cancer, and liver hepatocellular carcinoma spatial data. CONCLUSION: Our unique integrative pipeline identified a novel class public tumor-wide splice-derived neoantigen candidates and ASN-specific TCRs, offering a promising off-the-shelf immunotherapy approach for diverse cancer types and tackling the critical challenge of ITH in immunotherapy resistance. Citation Format: Darwin Kwok, Nicholas O. Stevers, Takahide Nejo, Lee H. Chen, Inaki Etxeberria, Jangham Jung, Kaori Okada, Maggie Colton Cove, Senthilnath Lakshmanachetty, Marco Gallus, Abhilash Barpanda, Chibo Hong, Gary KL Chan, Samuel H. Wu, Emilio Ramos, Akane Yamamichi, Jerry YZ Liu, Payal Watchmaker, Hirokazu Ogino, Atsuro Saijo, Aidan Du, Nadia Grishanina, James Woo, Aaron Diaz, Susan M. Chang, Joanna J. Phillips, Arun P. Wiita, Christopher A. Klebanoff, Joseph F. Costello, Hideho Okada. Novel public and tumor-wide neoantigens arising from clonal aberrant splicing events drive tumor-specific T-cell responses across diverse cancer types [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3907.

Starting from the Age of Enlightenment, a person’s ability of self-improvement, or perfectibility, is usually seen as a fundamental human feature. However, this term, introduced into the philosophical vocabulary by J.-J. Rousseau, gradually acquired additional meaning – largely due to the works of N. de Condorcet, T. Malthus and C. Darwin. Owing to perfectibility, human beings are not only able to work on themselves: by improving their abilities, they are also able to change their environment (both social and natural) and create favorable conditions for their existence. It is no coincidence that perfectibility became the key concept of the idea of social progress proposed by French thinkers in the Age of Enlightenment, despite the fact that later it was criticized, above all, by English authors, who justified its organic and biological nature and gave a different evolutionary interpretation to this concept, without excluding perfectibility from the philosophical vocabulary. In this article, we address the opposition and mutual counterarguments of these two positions. Beyond that, we draw a parallel with some of the ideas of S. Kapitsa, who proved to be not only a critic of Malthusianism but also a direct disciple of Condorcet. In the modern age, the ideas of human self-improvement caused the development of transhumanist movement. Condorcet is more relevant than ever, and today his theory of the progress of the human mind, which influenced the genesis of modern historical science, needs a re-thinking in the newest perspective of improving the mental and physical human nature with the help of modern technologies.

Sustainable Agriculture Research wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal are greatly appreciated. Sustainable Agriculture Research is recruiting reviewers for the journal. If you are interested in becoming a reviewer, we welcome you to join us. Please contact us for the application form at: sar@ccsenet.org &nbsp; Reviewers for Volume 9, Number 2 Adel Khashaveh, Islamic Azad University, Iran Darwin Pangaribuan, Lampung University, Indonesia Dietrich Darr, Hochschule Rhein-Waal, Germany Entessar Mohammad Al JBawi, General Commission for Scientific Agricultural Research, Syria Francesco Sunseri, Universit&agrave; Mediterranea di Reggio Calabria, Italy Gema Parra, Universidad de Ja&eacute;n, Spain Giuseppina Migliore, University of Palermo, Italy Gunnar Bengtsson, Sweden Inder Pal Singh, Guru Angad Dev Veterinary and Animal Science University (GADVASU), India Isaac Danso, Council for Scientific and Industrial Research-Oil Palm Research Institute, Ghana Kassim Adekunle Akanni, Olabisi Onabanjo University, Nigeria Katarzyna Panasiewicz, Poznan University of Life Sciences, Poland Manuel Teles Oliveira, University Tras os Montes Alto Douro (UTAD), Portugal Maren Langhof, Julius K&uuml;hn-Institut, Germany Murtazain Raza, Subsidiary of Habib Bank AG Zurich, Pakistan Nehemie T. Donfagsiteli, Institute of Medical Research and Medicinal Plants Studies, Cameroon Nicusor-Flavius Sima, University of Agricultural Studies and Veterinary Medicine Cluj-Napoca, Romania Sait Engindeniz, Ege University Faculty of Agriculture, Turkey Stefano Marino, University of Molise, Italy Subhash Chand, Central Agricultural Research Institute CARI Port Blair, India Suheb Mohammed, University of Virginia, United States Tenaw Workayehu, Hawassa Research Center, Southern Agricultural Research Institute, Ethiopia

Anastatus eurycanthae Gibson n. sp. (Eupelmidae: Eupelminae) is newly described as an egg parasitoid of Eurycanthacalcarata Lucas (Phasmida: Phasmatidae), an important pest of oil palm in Papua New Guinea. Both sexes are describedand illustrated by macrophotography and scanning electron microscopy. Basic biological data are provided on the parasi-toid. Six species are transferred from A. (Anastatus) Motschulsky to other genera, namely Eupelmus tennysoni Girault(1921) revived comb., Eupelmus (Eupelmus) darwini (Girault 1915) n. comb., Reikosiella (Hirticauda) pasteuri (Girault1915) n. comb., R. (Hirticauda) tricolor (Girault 1915) n. comb., Tineobius (Tineobius) adamsi (Yoshimoto & Ishii 1965) n. comb., and T. (Tineobius) crassipes (Yoshimoto & Ishii 1965) n. comb.

Several taxa of Nemobiinae and Trigonidiinae from some islands and coasts of Pacific Ocean and Andaman Sea (Indian Ocean) are considered. The tribes Marinemobiini Gorochov, 1985 and Burcini Gorochov, 1986 are briefly redescribed, and the tribes Nemobiini Saussure, 1877 and Pteronemobiini Vickery, 1973 are also discussed. Some genera of Marinemobiini (Marinemobius Gorochov, 1985, Apteronemobius Chopard, 1929 and Parapteronemobius Furukawa, 1970) as well as type species of Apteronemobius (A. longipes Chopard, 1929) are redescribed; Marinemobius and Parapteronemobius are restored from synonyms of Apteronemobius and Caconemobius Kirby, 1906, respectively (with the suggestion of three new combinations for the specific names); Eumarinemobius sundaicus gen. et sp. nov. is described from the Malay Peninsula and nearest islands, and former Apteronemobius darwini Otte et Alexander, 1983 is supposedly included in this genus (as E. darwini comb. nov.); Parapteronemobius sazanami kunashir subsp. nov. is described from the Kuril Islands. The tribe Burcini is restored from synonyms of Thetellini Otte et Alexander, 1983, and its following taxa are redescribed or described as new for the science: Burcus Gorochov, 1986 which is also restored from synonyms of Thetella Otte et Alexander, 1983; B. trilobulatus sp. nov. from Thailand; B. t. bunaken subsp. nov. from Indonesia; Paraburcus gen. nov. for Thetella elegans Kobayashi, 1983 (= P. elegans comb. nov.); Neoburcus tarutao gen. et sp. nov. from Thailand. The unavailable tribal name Thetellini is considered as a possible synonym of Nemobiini, and its type genus and species (Thetella and Th. oonoomba Otte et Alexander, 1983 from Australia) as well as some other genera from Pacific islands must be preliminary placed in this tribe, but the genus Caledonina Desutter-Grandcolas, 2016 from New Caledonia probably belongs to Pteronemobiini. Two generic names of Hawaiian Trigonidiinae (Zudella Gorochov, 1988 and Nudilla Gorochov, 1988) are restored from subgenera and synonyms of Trigonidium Rambur, 1838, respectively: the genus Zudella includes numerous Hawaiian species erroneously placed in Trigonidium (they are listed here); the genus Nudilla is here synonymised with Laupala Otte, 1994, syn. nov., and the neotype for Nudilla type species (Trigonidium pacificum Scudder, 1869) is here designated, as well as a new replacement specific name (N. danieli nom. nov.) is here given for the secondary homonym Laupala pacifica Otte, 1994. Also 169 new combinations for specific names in the two latter genera are proposed; T. kolekole Otte, 1994, syn. nov. and L. cerasina Otte, 1994, syn. nov. are synonymised with Z. hawaiiensis Gorochov, 1986 and N. pacifica (Scudder, 1869), respectively.

The conclusion from the dissertation is that the psychology of pregnancy in the Qur’an perspective can be understood as a science that studies the behavior of women at the time of pregnancy until birth in building a mentall powers and patterns in harmony with herself, with husband, family member, community, environment and with Allah. In the Qur’an, the psychological discussion of pregnancy covers the turmoil of emotion such as sad, happy. Also, the subject of psychology deals with the senses of the body. Pregnancy psychology, which relates to several biological changes, leads to both intrinsic and extrinsic and the stres due to adjustments to a social pressure. The suppression of stres includes aspects of both the supporting role of the family, and the pregnant women herself, the husband and even the health-care worker. The dissertation also discovered the psychology of pregnancy in the Qur’an, which talks about grief, joy , fear and worry, and so the author found some things related to the psychology of pregnancy in the Qur’an such as: The psychology of the mentally related pregnancy of feelings. The senses and the body, and the mind. And the Desire. This dissertation shares similarity of opinion to Chrissie P, Kaponda. (1996). Descamps, (2014), Deave T, Crowther, Angelica Y. Matos-Rios, (1995) Lori n; Rhodes, Osborne (2001) Nicole Kom-valdina (2012) Jeanne Rodier. Weber (1991). Nasaruddin Umar (2014), M. Darwis Hude, (2006), Nur Arfiyah Pebriani (2014) Fatma syilfana Dewi harahap (2015) who all share the same view that a pregnant woman has an emotional change in the birth of the unborn baby in her womb. The method used in this research is a qualitative and interview method using the maudhu 'i interpretation method. And the data used in this research is obtained through the library research. The steps in this study go through three steps of reading and exploring primary or secondary literature and then analyzing the data with an analistic descriptive framework, ultimately coming to conclusions based on the design and purpose of the research.

Ìfè tọ ́ dunni àti ìdájo ̣ ́ kó ipa pàtàkì nínú iṣe ̣ ́ àwọn òǹko ̣ ̀ wé alátinúdá láti ìgbà ̣ pípé wá àti títí di àkókò yìí. Bí àwọn iṣe ̣ ́ wo ̣ ̀ nyí ṣe po ̣ ̀ tó, ìwà o ̣ ̀ daràn àti ìdájo ̣ ́ ̣ kóòtù ni iṣẹ́ àwọn onímọ̀ tó ṣaajú fúnkamó jùlọ láì ka àwọn o ̣ ̀ nà ìfe ̣ ̀ tọ ́ dunni àti ̣ oríṣìí ìdájó mìíràn tó ń wáyé kún bàbàrà. Nítorí náà, a lo Ìkéde Àjọ Àgbáye àti ̣ Òfin Orílè èdè Nàìjíríà ti ọdún 1999 ge ̣ ́ gẹ ́ bí àte ̣ ̀ gùn láti ṣe àgbéye ̣ ̀ wò ohun tí a ̣ ń pè ni ìfè tọ ́ dunni, ìbáṣepo ̣ ̀ àti ìdájo ̣ ́ ge ̣ ́ gẹ ́ bí ó ṣe hàn nínú àwọn àsàyàn ìwé ̣ eré onítàn méje tí a mò -ọ ́ n-mọ sàyàn fún àgbéye ̣ ̀ wò. Èyí ni láti fi ìdí ìfe ̣ ̀ tọ ́ dunni ̣ múlè àti ìbáṣepo ̣ ̀ tó wà láàrin afe ̣ ̀ tọ ́ dunni àti ̣ ẹni tí a fè tọ ́ dùn nípase ̣ ̀ ìṣe ̣ ̀ dánìyàn, ̣ ọjó orí, e ̣ ̀ sìn, ipò àti àwọn o ̣ ̀ nà ìdájo ̣ ́ . Àwọn ìwé náà ni: Akínwùmí Ìṣo ̣ ̀ lá (1970) ̣ Ẹfúnṣetán Aníwúrà, TAA Ládélé (1971) Ìgbà Ló De, Adébáyò Fálétí (1972) ̣ Baṣò run Gáà, ̣ (1980) Wó n rò pé wèrè ni, ̣ Láwuyì Ògúnníran (1977) Ààrẹ-Àgò Aríkúyẹrí , Adéṣọlá Ọláté jú (2009) ̣ Iná Ràn àti Agboọlá Àyándìran (2016) Ààrò Wò rọ ̀ kọ ̀ .̣ Tíó rì Máàsì to níí ṣe pe ̣ ̀ lú ìbágbépo ̣ ̀ ẹ ̀ dá ni a fi ṣe òsùnwo ̣ ̀ n nítorí ̣ pé ohun gbogbo tí ó ṣẹlè nínú àwọn ìwé náà j ̣ ẹ mọ ìjẹgàba, ìré nij ̣ ẹ, ìjàfé tọ ̀ ọ ́ ̣ẹni. Ìwádìí fi hàn pé afé ayé, ìṣèlú, ọro ̣ ̀ ajé àti ìsinúbí ní ó je ̣ ́ okùnfa ìj ̣ ẹgàba èyí ti 2 Adéjùmò & Ṣàngótóye ̣ ó sì yọrí sì ìpànìyàn, ìbínú-òdì, ìfiniṣètùtù ọla, ìjínigbégbowó, ìfìyàjẹọmọdé, ìfọmọsòwò, ìmúnitìmó lé lo ̣ ́ nà àìto ̣ ́ , ìfiniṣerú àti ìfipámúnisìn Àwọn e ̣ ̀ tọ ́ mìíràn ̣ tí wọn tún tè lójú ni e ̣ ̀ tọ ́ ìwàláàyè, òmìnira ìdágbé, ìyì ọmọnìyàn, ìyanfanda ̣ àti ìkórajọ. Àbájáde ìwádìí láti inú àwọn ìwé eré onítàn tí a lò fún iṣẹ́ ìwádìí yìí fi yé wa pé́ ìfè tọ ́ dunni kò ní ṣe pe ̣ ̀ lú e ̣ ̀ dánìyàn tàbí e ̣ ̀ sìn ̣ ẹni tí wó n t ̣ ẹ è tọ ́ rẹ ̀ ̣ lójú. Ìdájó oríṣìí me ̣ ́ ta to farahàn nínú iṣe ̣ ́ yìí ni ìdájo ̣ ́ kóòtù, ìdájo ̣ ́ lọ ́ nà ìbíle ̣ ̀ ̣ àti ìdájó tìpátìkúùkù- mímú òfin lò lo ̣ ́ wọ ́ ara ̣ ẹni. Ìgúnlè iṣe ̣ ́ ìwádìí yìí ni pé ̣ ò rọ ̀ ìfe ̣ ̀ tọ ́ dunni àti ìdájo ̣ ́ kò j ̣ ẹ àjèjì ni àwùjọ Yorùbá, o ti wà nínú àṣà Yorùbá kí àwọn oyinbo tóó gòkè. Ìfè tọ ́ dunni ti a kò ba tètè mójútó le ṣe okùnfà òmíràn ̣ tí ó burú ju tàkó kọ ́ lọ, ṣùgbo ̣ ́ n ìdájó tìpátìkúùkù kò dára. Ìlànà ìbíle ̣ ̀ àti òfin ló ̣ dára jùlọ láti jà fún è tọ ́ ̣ẹni.

SCIENCE AND RELIGION: A New Introduction, 3rd edition by Alister E. McGrath. Hoboken, NJ: John Wiley and Sons, 2020. 272 pages. Paperback; $28.99. ISBN: 9781119599876. *Alister McGrath is a major international scholar who is prolific in his output. He has produced many popular books and academic tomes, and as a theological educator his output also includes many textbooks for students. Science and Religion: A New Introduction is now into its third edition and is an excellent introduction to the whole field of science and religion. The restructuring and inclusion of new material is designed to be helpful to the student, and reflects comments on the previous editions. The book introduces most of the areas of interaction between these bodies of thought, and I myself have used earlier editions in my own teaching, giving students a chapter of McGrath to start with for an essay, followed by more detailed material from elsewhere. *McGrath notes that science and religion are wide categories and serious study entails narrowing them down. He describes Ian Barbour's four models for interaction followed by what he calls four ways of imagining the relationship between them. The conflict model is rightly dismissed as a late nineteenth-century myth, and areas where conflict has been perceived, notably with Galileo and Darwin, are given the more nuanced treatment they deserve, thus dispelling the myths surrounding them. McGrath also gives a broader historical overview, refuting the further myth that the scientific revolution owed nothing to the medieval period. He describes the development of the Newtonian mechanistic model of the universe and brings us to the twentieth century with the development of the Big Bang theory. Regarding this last, it would have been good to note the pioneering work of Roman Catholic priest Georges Lemaître, often dubbed the "Father of the Big Bang," who, in contrast to Alexander Friedman, regarded solutions of Einstein's equations as physically realistic and not just mathematical curiosities. *McGrath moves on to a helpful chapter on religion and the philosophy of science. Some form of realism seems predominant and, indeed, the most rational position to take. It is interesting to note the adoption of "critical realism," including not only by science-religion scholars such as John Polkinghorne and others, but also such as the biblical scholar N. T. Wright and James Dunn. McGrath moves on to the role of explanation in science, noting how in science there are different methods for different sciences, and thus different levels of explanation across the different subdisciplines. Theology too has its own methods appropriate to its own object but there are differing views on the role of explanation. He discusses an important case study, that of "non-reductive physicalism" associated with Nancey Murphy and others. He also gives criteria for drawing an "inference to the best explanation." Various perspectives on the philosophy of science--logical positivism and the criteria of verification, falsificationism, and Kuhn's paradigm shifts--are discussed. Worthy of mention here would have been Imre Lakatos whose "methodology of scientific research programmes" has been applied to theology by Philip Hefner and Nancey Murphy. *Complementing the above there follows a useful chapter on science and the philosophy of religion. McGrath describes arguments for the existence of God, beginning with Aquinas's five ways. A section on the Kalām cosmological argument notes how this has been given a new lease on life by the Big Bang theory's postulation of a temporal origin to the universe, although it would have been good to note that the existence of the universe would demand an explanation even if it were to lack a temporal origin. He gives a careful analysis of Paley's natural theology, noting neglected aspects of Paley's work such as his responses to arguments of David Hume. He examines ways in which God may act in the world given the laws of nature uncovered by science, including through miracles, where he notes Hume's critique. However, as McGrath rightly says, Hume's critique needs to be qualified, since, on the one hand, he defines miracles as violations of laws of nature and yet, on the other, has a problem with inductive generalizations from past experience--which is just what laws of nature are. McGrath rightly sees evolutionary arguments debunking religion as committing the genetic fallacy and self-defeating if human rationality is flawed, since that could equally well affect judgments in areas other than religion, notably science. There is a good section on natural theology and the role of explanation. *In the next chapter, McGrath turns to models and analogies: first, as found within the natural sciences and then, within religion. After considering what the terms mean more generally, he gives specific examples for the sciences, including the kinetic theory of gases, wave-particle duality, Galileo's analogical reasoning which led him to postulate mountains on the moon, and Darwin's metaphor of "natural selection." In the theological sphere, he considers Aquinas's notion of analogia entis whereby the creation bears a likeness to its creator, and Ian Ramsey's model of the "divine economy" utilizing the Greek concept of oikonomia. He looks at Arthur Peacocke's theological application of models as linked to "critical realism," and Sally McFague's metaphors in theology--though he could perhaps have allowed more than one sentence on Janet Soskice. He then examines specific theological examples: creation and theories of the atonement. He has a helpful section on the notion of "mystery" in science and religion before returning to Ian Barbour on models. *McGrath's final chapter considers a number of contemporary debates. Noting Hume's distinction between "ought" and "is" he critiques the idea that science, say, evolutionary biology or neuroscience, can determine ethics and moral values. That leads to a more general critique of the imperialist stance that science can answer all interesting questions or that the only reality is that disclosed by science. An interesting example is mathematics, which discovers truths that do not belong to the natural sciences. It is also utterly astonishing that mathematics is effective in describing nature and very hard to explain on an atheistic view. *An important area considered is theodicy, which is arguably made more difficult by the long process of evolution, preceding the existence of humans by hundreds of millions of years. McGrath provides an overview of the helpful contributions of Christopher Southgate and his former student Bethany Sollereder. For these scholars, there is "no other way" for God to create such a rich diversity of creatures, with whom God suffers, and for whom God will bring eschatological fulfilment. On transhumanism, McGrath describes the approaches of Philip Hefner and Ted Peters who, while recognizing the creativity of technological enhancement, are also aware that, given fallen human nature, this can also be abused. *McGrath returns to the anthropic principle and fine-tuning. He says that fine-tuning is strongly consistent with a theistic perspective, but the debate about a multiverse as a possible explanation continues. He also considers the legitimacy of teleological language and directionality in biology. Simon Conway Morris's notion of convergent evolution may be the "best explanation" of what is observed and is resonant with a religious perspective but, like cosmological fine-tuning, does not prove that God exists. *McGrath concludes with two sections on the psychology of religion, considering whether this field can "explain away" religion. Religion may be "natural," but it is debatable as to whether that has any implication at all about the existence of God. Moreover, it is a long way from primitive apprehension of some vague supernatural agent to the systematic theology of, say, Thomas Aquinas or Karl Barth. To my mind, this is not unlike the difference--to give a scientific analogy--between the discovery of fire by early humans and the modern scientific understanding of combustion. *This is an excellent introduction to the field and very well suited to its pedagogic purpose. There are a few typographical errors (e.g., "magisterial" for "magisteria"). I also noticed that British cosmologist Paul Davies is mistakenly described as American. But these and my earlier minor points should not detract from a volume that provides a vital resource to educators and their students. *Reviewed by Rodney Holder, Emeritus Course Director, The Faraday Institute for Science and Religion, Cambridge, UK CB3 0UB.

Background:KZR-616 is a first-in-class selective inhibitor of the immunoproteasome, which is active in >15 autoimmune disease models, including murine models of systemic lupus erythematosus (SLE)/lupus nephritis (LN).1,2,3 Selective inhibition of the immunoproteasome modulates both innate and adaptive immune effector cells, resulting in reduced inflammatory T helper cell subsets (Th1 and Th17), increased regulatory T cells, and decreased plasma cells and autoantibodies. KZR-616 was well tolerated in two healthy volunteer studies of 100 subjects receiving up to 75 mg subcutaneously (SC). Target levels of immunoproteasome inhibition were observed at doses ≥30 mg.3,4 KZR-616 is currently in Phase 2 studies for several autoimmune indications, including the ongoing Phase 2 portion of the MISSION Study (KZR-616-002; NCT0339013) in patients with LN.Objectives:Results of the completed MISSION Phase 1b dose escalation portion of the study are reported.Methods:In the open-label, multicenter, dose escalation Phase 1b portion, SLE patients (per SLICC Classification Criteria) with SLEDAI ≥4 despite stable background immunosuppressant, anti-malarial, and/or corticosteroid therapy were administered weekly KZR-616 subcutaneously at doses of 45 mg (cohort 1), 60 mg (cohort 2), 60 mg following step-up doses of 30 mg and 45 mg (cohort 2a), 60 mg following a step-up dose of 30 mg (cohorts 2b, 2c) or 75 mg following a step-up dose of 30 mg (cohort 3) for 13 weeks with follow-up through Week 25 (W25); a lyophilized formulation was used for cohorts 2b, 2c and 3. The disease activity measures assessed were: SLEDAI-2K, Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI), 28 tender and swollen joint counts, Physician and Patient Global Assessments, and Patient Assessment of Pain. Safety and tolerability were assessed in the safety population (patients receiving at least one dose of KZR-616).Results:The Phase 1b portion of MISSION enrolled 47 SLE patients, including 2 patients with active proliferative LN. The most common treatment-emergent adverse events (TEAE) were injection site reactions, which were mostly mild. Infections occurred at a low rate, and there were no reports of peripheral neuropathy, prolonged hematologic AEs, or clinically significant laboratory abnormalities. No discontinuations were observed in cohorts 2b and 2c; no serious AEs were reported in cohort 3 and TEAEs were consistent with those reported in earlier cohorts. Mean values of all measures of disease activity improved in evaluable patients who completed the 13-week treatment period, and improvements were generally maintained at W25. All patients with elevated anti-double-stranded DNA antibody (anti-dsDNA) levels at baseline (n=7) had a reduction in levels with 3 of 7 experiencing a >50% reduction in their levels. Two of two patients with active proliferative LN had a >50% reduction in UPCR and experienced reductions in SLEDAI-2K scores as well as anti-dsDNA levels. Exposure to KZR-616, similar to that reported in healthy volunteers, was dose-proportional across doses, and no accumulation was observed.Conclusion:KZR-616 SC, once weekly for 13 weeks up to 75 mg, appears to be safe and well-tolerated in patients with active SLE on stable background therapy in the MISSION Phase 1b. At doses ≥45mg, efficacy was noted, including improvements in proteinuria in two of two patients with LN and serologic improvement in all 7 patients with quantifiable levels of anti-dsDNA antibodies at baseline. KZR-616 60 mg SC weekly for 24 weeks is currently being evaluated in the MISSION Phase 2 in patients with LN. Based on the results of MISSION, inhibition of the immunoproteasome with KZR-616 represents a novel strategy to treat autoimmune diseases.References:[1]Basler M et al. Clin Exp Rheumatol 2015 (suppl 92);S74.[2]Muchamuel T et al. Ann Rheumatol Dis 2018;77(suppl 2);685.[3]Muchamuel T et al. ASN 2020 Virtual Conference.[4]Snyder B et al. ACR/ARP 2019 Annual Meeting.[5]Fan RA et al. ACR/ARP 2019 Annual Meeting.Acknowledgements:Kezar Life Sciences acknowledges the support of site investigators and patient participants in the MISSION studyDisclosure of Interests:Richard Furie Consultant of: Genentech;Kezar Life Sciences, Grant/research support from: Kezar Life Sciences, SV Parikh Consultant of: Aurinia Pharmaceuticals, BMS, GlaxoSmithKline, and Kezar Life Sciences, Grant/research support from: Aurinia Pharmaceuticals;EMD-Serono, Jinhai Wang Shareholder of: Kezar Life Sciences, Employee of: Kezar Life Sciences, Darrin Bomba Shareholder of: Kezar Life Sciences, Employee of: Kezar Life Sciences, Richard Leff Employee of: Kezar Life Sciences [part-time], Christopher Kirk Shareholder of: Kezar Life Sciences, Employee of: Kezar Life Sciences -- full-time employee, Noreen Henig Shareholder of: Kezar Life Sciences, Employee of: Kezar Life Sciences

AbstractAll known trachyuropodid mites (Acari: Uropodina: Trachyuropodidae) are listed together with diagnoses of the family Trachyuropodidae and trachyuropodid genera. A new illustrated key to trachyuropodid genera is also presented. The second species of the genus Trachyibana (T. kozari sp. nov.) is described and illustrated from Singapore. Forty eight new combinations are also presented: Arculatatrachys darwini (Kontschán and Starý, 2013) comb. nov.; Arculatatrachys newtoni (Kontschán, 2010) comb. nov.; Bostocktrachys berlesesellnickia (Hirschmann, 1976) comb. nov.; B. extremica (Kontschán and Starý, 2013) comb. nov.; B. kiewensis (Hirschmann, 1976) comb. nov.; B. myrmecophila (Wiśniewski and Hirschmann, 1992) comb. nov.; B. plagiata (Hirschmann, 1976) comb. nov.; B. zicsii (Hirschmann, 1976) comb. nov.; Castritrachys quadriauricularia (Hirschmann, 1976) comb. nov.; Cristicepstrachys sinuata (Berlese, 1904) comb. nov.; Cephalojanetia multituberculata (Hirschmann, 1976) comb nov.; C. tuberosa (Hirschmann, 1976) comb. nov.; C. dentata (Kontschán, 2007) comb. nov.; Cephalouropoda alapaducta (Hirschmann, 1976) comb. nov.; Excavatatrachys auricularia (Costa, 1962) comb. nov.; E. longicornuta (Hirschmann, 1976) comb. nov.; E. longicornutasimilis (Hirschmann, 1976) comb. nov.; E. poppi (Hirschmann and Zirngiebl-Nicol, 1969) comb. nov.; E. quadricornuta (Hirschmann, 1976) comb. nov.; E. sellnicki (Hirschmann and Zirngiebl-Nicol, 1969) comb. nov.; Graecatrachys bali (Kontschán and Starý, 2013) comb. nov.; G. endrodyi (Hirschmann, 1976) comb. nov.; G. ghanaensis (Hirschmann, 1976) comb. nov.; G. mesofovea (Hirschmann, 1976) comb. nov.; G. mesofoveasimilis (Hirschmann, 1976) comb. nov.; G. represa (Hirschmann, 1976) comb. nov.; G. rufipes (Hirschmann, 1976) comb nov.; Magnatrachys dacica (Huţu, 1973) comb. nov.; M. imperforata (Berlese, 1904) comb. nov.; M. mexicana (Hirschmann, 1976) comb. nov.; M. pecinai (Hirschmann, 1976) comb. nov.; M. schusteri (Hirschmann, 1976) comb. nov.; M. schusterisimilis (Hirschmann, 1976) comb. nov.; Trogulotrachys ablesi (Hirschmann, 1976) comb. nov.; T. celtica (Halbert, 1907) comb. nov.; T. hirschmanni (Pecina, 1980) comb. nov.; T. kinsella (Kontschán et al., 2010) comb. nov.; T. michaeli (Ewing, 1909) comb. nov.; T. wasmanniana (Berlese, 1903) comb. nov.; T. willmanni (Hirschmann and Zirngiebl-Nicol, 1969) comb. nov.; Urojanetia baloghi (Hirschmann, 1976) comb. nov.; U. baloghisimilis (Hirschmann, 1976) comb. nov.; U. belunensis (Lombardini, 1962) comb. nov.; U. hexaspinosa (Hirschmann, 1976) comb. nov.; U. mahunkai (Hirschmann, 1976) comb. nov.; U. similicoccinea (Hiramatsu, 1979) comb. nov.; Urotrachytes formicariasimilis (Hirschmann, 1975) comb. nov.; and Ur. ponticuli (Karg, 1989) comb. nov.

Abstract. Iswanto AH, Amanda DW, Gea S, Susilowati A, Fatriasari W, Darwis A, Lubis MAR, Sucipto T, Syahidah, Subekti N, Hartono R, Sutiawan J, Hidayat W, Kim NH. 2023. Characteristics of Simalambuo (Lophopetalum sp.) wood from Nias Island, North Sumatra Province, Indonesia. Biodiversitas 24: 4193-4201. Simalambuo (Lophopetalum sp.) wood is commonly used for construction materials in Nias Island, North Sumatra Province especially in the aftermath of the devastating earthquake that affected the region. However, information regarding the fundamental characteristics of this wood has not been available. Therefore, this research aimed to evaluate the basic properties of Simalambuo wood, such as its physical, mechanical, chemical, and natural durability. The destructive method was used to determine the physical and mechanical parameters (i.e., specific gravity, moisture content, shrinkage, MOE, MOR, and hardness) using a small clear specimen sample under the BS 373 standard (1957). The chemical components of wood (i.e., holocellulose, cellulose, lignin, extractives) were analyzed using a variety of methods, including CRC Press methods, LAP NREL 003 standard, and TAPPI. Meanwhile, the SNI 7207-2014 standard was utilized to evaluate its resistance against subterranean termites. The results showed that Simalambuo wood has an average specific gravity of 0.42 and a T/R ratio of 1.78. Based on its specific gravity, the wood is classified within the strength class III-IV. It also exhibits a reduced cellulose and extractive content, along with a higher proportion of lignin. In terms of durability, it is classified as class IV, implying non-resistance to termites’ attack and necessitating wood preservation treatment for its practical application. The findings of this study suggest the application of this wood is recommended for light construction, furniture, and other functions, but not for heavy construction.

Abstract. Mushawwir A, Arifin J, Darwis D, Puspitasari T, Pengerteni DS, Nuryanthi N, Perman R. 2020. Liver metabolic activities of Pasundan cattle induced by irradiated chitosan. Biodiversitas 21: 5571-5578. A total of one hundred and twenty-five, 2-3 year old male Pasundan cattle were used as livestock samples during the three months of this research. They were selected from the local cattle breeding and development center in Ciamis. The animal samples were randomly allocated to 5 treatment groups. One group served as the control, or without irradiated chitosan, while the others were used as treatment in varying levels. Each treatment group involved five replicates with 25 Pasundan bulls per treatment i.e five Pasundan bulls per replication. Each group was provided with the following rations: C0 = Control group, without IC (0 ppm IC); C1 = 350 ppm Irradiated Chitosan (IC); C2 = 400 ppm IC; C3 = 450 ppm IC; and C4 = 500 ppm IC. Irradiated chitosan was obtained through the following steps: extraction, deacetylation, and irradiation of chitin using gamma rays. Five mL of blood samples were collected from each bull at the beginning of each month of this experiment, which totaled three months. The blood samples were sucked from the tail/coccygeal vein using a sterilized syringe and vacuum tube containing K3EDTA. The plasma was used to determine the concentration of parameters related to liver metabolism through an automatic biochemical analyzer Kenza 240TX model from Biolabo, using a commercial kit. Each procedure was followed based on the Biolabo kit (Franch) and Randox kit (UK). This study showed that IC reduces the activity of glycogenolysis and glycolysis, but is accompanied by improvements in the biochemical conditions of liver cells. This is a favorable condition for the metabolism of Pasundan bulls in order to enhance their growth and reproduction.

Artistic collaboration involves a certain loss of self, because it arises out of the merging of participants. In this sense collaboration questions the notion of the creative individual and the myth of the isolated artistic genius. As such, artistic collaborations can be subversive interventions into the concept of authorship and the ideologies that surround it (Smith 189-194). Collaborations also often simultaneously superimpose many different approaches to the collaborative process. Collaboration is therefore a multiplicitous activity in which different kinds of interactivity are interlinked; this process may also be facilitated by improvisation which allows for continuous modification of the interactions (Smith and Dean, Improvisation). Even when we are writing individually, we are always collaborating with prior texts and employing ideas from others, advice and editing suggestions. This eclectic aspect of creative work has led some to argue that collaboration is the dominant mode, while individual creativity is an illusion (Stillinger; Bennett 94-107). One of the reasons why collaboration tends to be multiplicitous is that contemporary creative endeavour sometimes involves collaboration across different media and with computers. Artworks are created by an ‘assemblage’ of different expertises, media, and machines in which the computer may be a ‘participant’. In this respect contemporary collaboration is what Katherine Hayles calls posthuman: for Hayles ‘the posthuman subject is an amalgam, a collection of heterogeneous components, a material-informational entity whose boundaries undergo continuous construction and reconstruction (Hayles 3). Particularly important here is her argument about the conceptual shifts that information systems are creating. She suggests that the binary of presence and absence is being progressively replaced in cultural and literary thought by the binary of pattern and randomness created by information systems and computer mediation (Hayles 25-49). In other words, we used to be primarily concerned with human interactions, even if sometimes it was the lack of them, as in Roland Barthes concept of ‘the death of the author’. However, this has shifted to our concern with computer systems as methods of organisation. Nevertheless, Hayles argues, computers can never totally replace embodied human subjects, rather we need to continually negotiate between presence and pattern, absence and randomness (Hayles 25-49). This very negotiation is central to many computer-mediated collaborations. Our own collaborative practice—Roger is primarily a musician and Hazel primarily a writer but we both have interdisciplinary performance and technological expertise—spans 15 years and has resulted in approximately 18 collaborative works. They are all cross-media: initially these brought together word and sound; now they sometimes also include image. They all involve multiple forms of collaboration, improvised and unfixed elements, and computer interfaces. Here we want to outline some of the stages in the making of our recent collaboration, Time, the Magician, and its ‘posthuman’ engagement with computerised processes. Time, the Magician is a collaborative performance and sound-video piece. It combines words, sound and image, and involves composed and improvised elements as well as computer mediation. It was conceived largely by us, but the first performance, at the Sydney Conservatorium of Music in 2005 also involved collaboration with Greg White (sound processing) and Sandy Evans (saxophone). The piece begins with a poem by Hazel, initially performed solo, and then juxtaposed with live and improvised sound. This sound involves some real-time and pre-recorded sampling and processing of the voice: this—together with other sonic materials—creates a ‘voicescape’ in which the rhythm, pitch, and timbre of the voice are manipulated and the voice is also spatialised in the performance space (Smith and Dean, “Voicescapes”). The performance of the poem is followed (slightly overlapping) by screened text created in the real-time image-processing program Jitter, and this is also juxtaposed with sound and voice samples. One of the important aspects of the piece is its variability: the video-manipulated text and images change both in order and appearance each time, and the sampling and manipulation of the voice is different too. The example here shows short extracts from the longer performance of the work at the Sydney 2005 event. (This is a Quicktime 7 compressed video of excerpts from the first performance of Time, the Magician by Hazel Smith and Roger Dean. The performance was given by austraLYSIS (Roger Dean, computer sound and image; Sandy Evans, saxophone; Hazel Smith, speaker; Greg White, computer sound and sound projection) at the Sydney Conservatorium of Music, October 2005. The piece in its entirety lasts about 11 minutes, while these excerpts last about four minutes, and are not cross-faded, but simply juxtaposed. The piece itself will later be released elsewhere as a Web video/sound piece, made directly from the sound and the Jitter-processed images which accompany it. This Quicktime 7 performance video uses AAC audio compression (44kHz stereo), H.264 video compression (320x230), and has c. 15fps and 200kbits/sec.; it is prepared for HTTP fast-start streaming. It requires the Quicktime 7 plugin, and on Macintosh works best with Safari or Firefox – Explorer is no longer supported for Macintosh. The total file size is c. 6MB. You can also access the file directly through this link.) All of our collaborations have involved different working processes. Sometimes we start with a particular topic or process in mind, but the process is always explorative and the eventual outcome unpredictable. Usually periods of working individually—often successively rather than simultaneously—alternate with discussion. We will now each describe our different roles in this particular collaboration, and the points of intersection between them. Hazel In creating Time, the Magician we made an initial decision that Roger—who would be responsible for the programming and sound component of the piece—would work with Jitter, which we had successfully used for a previous collaboration. I would write the words, and I decided early on that I would like our collaboration to circle around ideas—which interested both Roger and me—about evolution, movement, emergence, and time. We decided that I would first write some text that would then be used as the basis of the piece, but I had no idea at this stage what form the text would take, and whether I would produce one continuous text or a number of textual fragments. In the early stages I read and ‘collaborated with’ a number of different texts, particularly Elizabeth Grosz’s book The Nick of Time. I was interested in the way Grosz sees Darwin’s work as a treatise on difference—she argues that for Darwin there are no clear-cut distinctions between different species and no absolute origin of the species. I was also stimulated by her idea that political resistance is always potential, if latent, in the repressive regimes or social structures of the past. As I was reading and absorbing the material, I opened a file on my computer and—using a ‘bottom-up’ approach—started to write fragments, sometimes working with the Grosz text as direct trigger. A poem evolved which was a continuous whole but also discontinuous in essence: it consisted of many small fragments that, when glued together and transformed in relation to each other, reverberated though association. This was appropriate, because as the writing process developed I had decided that I would write a poem, but then also disassemble it for the screened version. This way Roger could turn each segment into a module in Jitter, and program the sequence so that the texts would appear in a different order each time. After I had written the poem we decided on a putative structure for the work: the poem would be performed first, the musical element would start about halfway through, and the screened version—with the fragmented texts—would follow. Roger said that he would video some background material to go behind the texts, but he also suggested that I design the texts as visual objects with coloured letters, different fonts, and free spatial arrangements, as I had in some previous multimedia pieces. So I turned the texts into visual designs: this often resulted in my pulling apart sentences, phrases and words and rearranging them. I then converted the texts files into jpg files and gave them to Roger to work on. Roger When Hazel gave me her 32 text images, I turned these into a QuickTime video with 10 seconds per image/frame. I also shot a 5 minute ‘background’ video of vegetation and ground, often moving the camera quickly over blurred objects or zooming in very close to them. The video was then edited as a continually moving sequence with an oscillation between clearly defined and abstracted objects, and between artificial and natural ones. The Jitter interface is constructed largely as a sequence of three processing modules. One of these involves continuously changing the way in which two layers (in this case text and background) are mixed; the second, rotation and feedback of segments from one or both layers; and the third a kind of dripping across the image, with feedback, of segments from one or both layers. The interface is performable, in that the timing and sequence can be altered as the piece progresses, and within any one module most of the parameters are available for performer control—this is the essence of what we call ‘hyperimprovisation’ (Dean). Both text and image layers are ‘granulated’: after a randomly variable length of time—between 2 and 20 seconds or so—there is a jump to a randomly chosen new position in the video, and these jumps occur independently for the two layers. Having established this approach to the image generation, and the overall shape of the piece (as defined above), the remaining aspects were left to the creative choices of the performers. In the Sydney performance both Greg White and I exploited real-time processing of the spoken text by means of the live feed and pre-recorded material. In addition we used long buffers (which contained the present performance of the text) to access the spoken text after Hazel had finished her performed opening segment. I worked on the sound and speech components with some granulation and feedback techniques, throughout, while Greg used a range of other techniques, as well as focusing on the spatial movement of the sound around four loudspeakers surrounding the performance and listening space. Sandy Evans (saxophone)—who was familiar with the overall timeline—improvised freely while viewing the video and listening to our soundscape. In this first performance, while I drove the sound, the computer ‘posthumanly’ (that is without intervention) drove the image. I worked largely with MSP (Max Signal Processing), a part of the MAX/MSP/Jitter suite of platforms for midi, sound and image, to complement sonically the Jitter-mediated video. So processes of granulation, feedback, spatial rotation (of image) or redistribution (of sound)—as well as re-emergence of objects which had been retained in the memory of the computer—were common to both the sound and image manipulation. There was therefore a degree of algorithmic synaesthesia—that is shared algorithms between image and sound (Dean, Whitelaw, Smith, and Worrall). The collaborative process involved a range of stimuli: not only with regard to those of process, as discussed, but also in relation to the ideas in the text Hazel provided. The concepts of evolution, movement, and emergence which were important to her writing also informed and influenced the choice of biological and artificial objects in the background video, and the nature and juxtaposition of the processing modules for both sound and image. Conclusion If we return to the issues raised at the beginning of this article, we can see how our collaboration does involve the merging of participants and the destabilising of the concept of authorship. The poem was not complete after Hazel had written it—or even after she had dislocated it—but is continually reassembled by the Jitter interface that Roger has constructed. The visual images were also produced first by Hazel, then fused with Roger’s video in continuously changing formations through the Jitter interface. The performance may involve collaboration by several people who were not involved in the original conception of the work, indicating how collaboration can become an extended and accumulative process. The collaboration also simultaneously superimposes several different kinds of collaborative process, including the intertextual encounter with the Grosz text; the intermedia fusion of text, image and sound; the participation of a number of different people with differentiated roles and varying degrees of input; and collaboration with the computer. It is an assemblage in the terms mentioned earlier: a continuously modulating conjunction of different expertises, media, and machines. Finally, the collaboration is simultaneously both human and posthuman. It negotiates—in the way Hayles suggests—between pattern, presence, randomness, and absence. On the one hand, it involves human intervention (the writing of the poem, the live music-making, the shooting of the video, the discussion between participants) though sometimes those interventions are hidden, merged, or subsumed. On the other hand, the Jitter interface allows for both tight programming and elements of variability and unpredictability. In this way the collaboration displaces the autonomous subject with what Hayles calls a ‘distributed system’ (Hayles 290). The consequence is that the collaborative process never reaches an endpoint: the computer interface will construct the piece differently each time, we may choose to interact with it in performance, and the sound performance will always contain many improvised and unpredictable elements. The collaborative process, like the work it produces, is ongoing, emergent, and mutating. References Bennett, Andrew. The Author. London: Routledge, 2005. Dean, Roger T. Hyperimprovisation: Computer Interactive Sound Improvisation; with CD-ROM. Madison, WI: A-R Editions, 2003. Dean, Roger, Mitchell Whitelaw, Hazel Smith, and David Worrall. “The Mirage of Real-Time Algorithmic Synaesthesia: Some Compositional Mechanisms and Research Agendas in Computer Music and Sonification.” Contemporary Music Review, in press. Grosz, Elizabeth. The Nick of Time: Politics, Evolution and the Untimely. Sydney: Allen and Unwin, 2004. Hayles, N. Katherine. How We Became Posthuman: Virtual Bodies in Cybernetics, Literature, and Informatics. Chicago: U of Chicago P, 1999. Smith, Hazel. Hyperscapes in the Poetry of Frank O’Hara: Difference, Homosexuality, Topography. Liverpool: Liverpool UP, 2000. Smith, Hazel, and Roger T. Dean. Improvisation, Hypermedia and the Arts since 1945. London: Harwood Academic, 1997. ———. “Voicescapes and Sonic Structures in the Creation of Sound Technodrama.” Performance Research 8.1 (2003): 112-23. Stillinger, Jack. Multiple Authorship and the Myth of Solitary Genius. Oxford: Oxford UP, 1991. Citation reference for this article MLA Style Smith, Hazel, and Roger T. Dean. "Posthuman Collaboration: Multimedia, Improvisation, and Computer Mediation." M/C Journal 9.2 (2006). echo date('d M. Y'); ?> <http://journal.media-culture.org.au/0605/14-smithdean.php>. APA Style Smith, H., and R. Dean. (May 2006) "Posthuman Collaboration: Multimedia, Improvisation, and Computer Mediation," M/C Journal, 9(2). Retrieved echo date('d M. Y'); ?> from <http://journal.media-culture.org.au/0605/14-smithdean.php>.

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