Articoli di riviste: "D-129"

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Shrestha, J. N. B., W. J. Boylan e W. E. Rempel. "Evaluation of sheep genetic resources in North America: Milk production and composition of purebred, crossbred and synthetic populations". Canadian Journal of Animal Science 88, n. 4 (1 dicembre 2008): 569–76. http://dx.doi.org/10.4141/cjas08044.

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Purebreds, crossbreds and synthetic populations of sheep in North America of divergent genetic types produced 47–103 litres of milk for 121–144 d, consistent with "non dairy-type" breeds; however, this was substantially less than the 200–330 kg of milk per lactation characteristic of "dairy" type breeds in Europe and the Middle East countries. Among established breeds, the Suffolk (Su) breed produced significantly more total and daily milk yield, respectively, for a longer lactation (79 litres and 589 mL for 139 d), followed by the Rambouillet (Ra), Targhee (T) and Dorset (D) breeds (60–62 litres and 422–542 mL for 120–132 d), while the Lincoln (L) breed produced significantly less (48 litres and 285 mL for 128 d). Among fecund-type breeds and their crosses, Finnsheep (F) and Romanov (Ro) breeds produced significantly less (50–55 litres and 425–463 mL, for 122–129 d), while Ro × F produced significantly more milk (91 litres and 744 mL for 126 d), followed by F × Ro (60 litres and 505 mL for 128 d). Among other crossbreds, F × Ra produced significantly more milk (66 litres and 434 mL for 136 d) followed by L × Ra, L × D, F × L, F × Ra (49–60 litres and 296–385 mL for 123–136 d), while Ra × D produced significantly less (47 litres and 245 mL for 121 d). Among multiple breed composite populations, the Outaouais (O) and Rideau (R) Arcott breeds and their crosses had the highest milk production, e.g., R and R × O produced significantly more milk (95–103 litres and 754–820 mL for 131–144 d) than O and O × R (74–80 litres and 621–693 mL for 124–142 d). Concurrently, Synthetic I (½ F, ½ L) produced significantly less (58 litres and 494 mL for 134 d), while Synthetic III (¼ F, ¼ L, ¼ D, ¼ Ra) produced significantly more milk (91 litres and 673 mL, P > 0.05, for 130 d), and Synthetic II (½ D, ½ Ra) was intermediate (74.8 litres and 621 mL for 129 d); however, lactation length was consistent. Sheep breeds in North America exhibited diversity that was substantial for milk yield, but negligible for lactation length, as well as fat, protein, lactose and solid-not-fat content. Lack of inherent potential for milk production continues to be a serious constraint towards development of commercial dairy sheep industry. In the absence of "dairy-type" breeds, superior milk production in the Rideau Arcott breed (with East Friesian lineage) and their crosses demonstrates considerable promise for further improvement, thus increasing the efficiency of sheep production. Key words: Milk yield and composition, sheep breeds, synthetic sheep, Arcott breeds

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Aijmer, Karin, Arne Olofsson, Marko Modiano, Ann-Marie Svensson, Magnus Ankarsjö, Monica Armini, Sabina Kielow et al. "Reviews and notices". Moderna Språk 93, n. 1 (1 giugno 1999): 116–36. http://dx.doi.org/10.58221/mosp.v93i1.9745.

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Includes the following reviews: pp. 116-117. Karin Aijmer. Carter, R. & McCarthy, M., Exploring Spoken English. pp. 117-118. Karin Aijmer. Knowles, G., Wichmann, A. & Alderson, P. (eds), Working wirh Speech. pp. 118-121. Arne Olofsson. Barlach, E., Call English, An English Grammar for Danish Students. pp. 121-123. Marko Modiano. Honey, J., Language is Power: The Story of Standard English and its Enemies. p. 123. Ann-Marie Svensson. Freeborn, D., From Old English to Standard English. pp. 124-126. Magnus Ankarsjö. Homer, S., Fredric Jameson: Marxism, Hermeneutics, Postmodernism. pp. 126-127. Monica Armini. Cixous, H., Stigmata: Escaping Texts. pp. 127-128. Sabina Kielow. Browning, B., Infectious Rythm: Metaphors of Contagion and the Spread of African Culture. + Kanneh, K., African Identities: Race, Nation and Culture in Ethnography. p. 128. Ronald Paul. Jameson, F., The Cultural Turn: Selected Writings on the Postmodern, 1983-1998. pp. 129-130. Andrea Kalman. Åhlander, L., Lömska ord och fällor - tysk ordkunskap. pp. 131-132. Oliver Jahraus. Nünning, A. (Hrsg.), Metzler Lexikon, Literatur und Kulturtheorie, Ansätze - Personen - Grundbegriffe. pp. 132-135. Tom Conner. Lucey, M., Gide's Bent. Sexuality, Politics, Writing. pp. 135-136. Tom Conner. Kerdellant, CH., Les chroniques de l'ingénieur Norton. Condidences d'un Américain à Paris.

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Bilenka, O. N. "Assessment of shallot collection accessions in breeding for yield capacity". Genetičnì resursi roslin (Plant Genetic Resources), n. 23 (2018): 58–66. http://dx.doi.org/10.36814/pgr.2018.23.05.

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Goal. To evaluation of the shallot gene pool for bulb yield and its components, resistance to viral diseases and to select the most valuable accessions for breeding programs. Results and Discussion. The article presents the results of evaluating 25 shallot accessions for yield and resistance to viral diseases. Five accessions with very high bulb yields (> 135% related to the standard) were selected from the following regions of Ukraine (from the Dnipropetrovska region - D-135 (13.1 t/ha); from the Poltavska region - D-127 (13.9 t/ha); from the Kharkivska region - D-15 (14.0 t/ha), D-34 (14.9 t/ha)) and from the Netherlands (Bonilla (15.9 t/ha). Accessions with high yields (116 - 135% related to the standard) were from the Dnipropetrovska region (D-136 (11.2 t/ha), varieties Olviia (12.3 t/ha) and Kushchyovka Kharkovskaya (12.6 t/ha). Ten accessions were the best in terms of bulb weight, exceeding the standard by 3.0 - 8.3 g:- D-33 (14.2 g), Olviia (14.5 g), D-4 (14.7 g), D- 133 (15.1 g), D-137 (15.2 g), D-130 (15.7 g), D-127 (15.9 g), D-15 (16.6 g), D- 34 (18.3 g), and Bonilla (19.5 g). Seven accessions were noticeable for the bulb number per bulb stem: from the Dnipropetrovska region (D-136 (6.1 bulbs), D-123 (7.0 bulbs), D-124 (7.4 bulbs), D-135 (7.4 bulbs), D-137 (6.4 bulbs), and D-129 (8.0 bulbs)) and from the Netherlands (Bonilla (6.1 bulbs). The following accessions were distinguished by resistance to viral diseases (onion yellow dwarf and mosaic) as sources for breeding: with very high resistance (9 points) - D-120 from Russia, 12 accessions with high resistance (7 points) from Ukraine (D- 4, D-26, D-136, D-125, D-127, D-133, D-130, D-123, D-126, D-137, and D-140) and Bonilla from the Netherlands. Accessions D-127 (Poltavska region), D-137 (Dnipropetrovska region), D-34 and D-15 (Kharkivska region), Bonilla (Netherlands) with a set of traits are of practical interest for breeding. Conclusions. Having studied 25 shallot collection accessions in 2016 – 2018, we distinguished the following accessions: by bulb yield - 8 accessions (11.7 - 15.9 t/ha), by bulb weight - 10 accessions (14.2 - 18.3 g), by the bulb number per bulb stem - 7 accessions (6.1 – 8.0 bulbs), by resistance to viral diseases - 13 accessions (7 – 9 points), by a set of valuable economic traits – 5 accessions.

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Zhu, Liyan, Sang-Hee Shin, Roshan Payapulli, Taiki Machii, Mizuki Motoyoshi, Noriharu Suematsu, Nick M. Ridler e Stepan Lucyszyn. "3-D Printed Rectangular Waveguide 123–129 GHz Packaging for Commercial CMOS RFICs". IEEE Microwave and Wireless Technology Letters 33, n. 2 (febbraio 2023): 157–60. http://dx.doi.org/10.1109/lmwt.2022.3220364.

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Lai, Kok Song, Khatijah Yusoff e Maziah Mahmood. "Morphological and Physiological Characterization of Embryogenic and Non-embryogenic Tissues of Centella asiatica". Plant Tissue Culture and Biotechnology 24, n. 1 (23 giugno 2014): 125–29. http://dx.doi.org/10.3329/ptcb.v24i1.19257.

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Ransley, Joan Kathleen, Elizabeth Faye Taylor, Yara Radwan, Meaghan Sarah Kitchen, Darren Charles Greenwood e Janet Elizabeth Cade. "Does nutrition education in primary schools make a difference to children’s fruit and vegetable consumption?" Public Health Nutrition 13, n. 11 (26 marzo 2010): 1898–904. http://dx.doi.org/10.1017/s1368980010000595.

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AbstractObjectiveTo explore whether initiatives to promote fruit and vegetables in primary schools are associated with changes in children’s diet.DesignCross-sectional dietary survey. Main outcome measures were intakes of fruit, vegetables and key nutrients; and a score for initiatives promoting fruit and vegetables in school.SettingOne hundred and twenty-nine English primary schools.SubjectsYear 2 children (aged 6–7 years,n2530).ResultsIn schools running a gardening club, children ate more vegetables, 120 (95 % CI 111, 129) g/d, compared with those that did not, 99·3 (95 % CI 89·9, 109) g/d; and where parents were actively involved in school initiatives to promote fruit and vegetables, children’s intake of vegetables was higher, 117 (95 % CI 107, 128) g/d, compared with those where parents were not involved, 105 (95 % CI 96·2, 114) g/d. In schools that achieved a high total score (derived from five key types of initiatives to promote fruit and vegetables in school) children ate more vegetables, 123 (95 % CI 114, 132) g/d, compared with those that did not, 97·7 (95 % CI 88·7, 107) g/d.ConclusionsGardening, parental involvement and other activities promoting fruit and vegetables to children in school may be associated with increased intake of vegetables but not fruit. These effects were independent of deprivation status and ethnicity.

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Dobrokhotova, E. Yu, e A. V. Sofronov. "The use of vitamin D in endometriosis treatment". Russian Journal of Woman and Child Health 6, n. 2 (2023): 126–29. http://dx.doi.org/10.32364/2618-8430-2023-6-2-126-129.

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The article reviews the literature on the use of vitamin D in endometriosis treatment. Endometriosis, one of the most common health problems in the female population, is an estrogen-dependent chronic inflammatory disease. Endometriosis affects 10-15% of all women of reproductive age and 35–50% of women with chronic pelvic pain and/or infertility. Despite multiple studies in all aspects of endometriosis, the selection of the most effective individualized combination treatment options for each patient is still considered as a pressing issue. Animal experiments and clinical trials have demonstrated multiple immune system changes in endometriosis occurring at different levels, from aberrant cytokine signaling to alterations of the immune system cell populations. There is a growing number of recent reports in the international and domestic literature describing the impact of vitamin D on the clinical course of endometriosis and the options of its use in this disease. There is a pathogenetic rationale for involving vitamin D in combination therapy of endometriosis in view of its immunomodulatory, anti-proliferative and anti-angiogenic properties. However, it is suggested that further studies are needed to determine an optimum therapeutic dose of vitamin D for different endometriosis types. KEYWORDS: vitamin D, colecalciferol, calcitriol, endometriosis, ectopic endometrium, vitamin D deficiency. FOR CITATION: Dobrokhotova E.Yu., Sofronov A.V. The use of vitamin D in endometriosis treatment. Russian Journal of Woman and Child Health. 2023;6(2):126–129 (in Russ.). DOI: 10.32364/2618-8430-2023-6-2-126-129.

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Papaldo, Paola, Massimo Lopez, Enrico Cortesi, Eugenio Cammilluzzi, Mauro Antimi, Edmondo Terzoli, Giuseppe Lepidini et al. "Addition of Either Lonidamine or Granulocyte Colony-Stimulating Factor Does Not Improve Survival in Early Breast Cancer Patients Treated With High-Dose Epirubicin and Cyclophosphamide". Journal of Clinical Oncology 21, n. 18 (15 settembre 2003): 3462–68. http://dx.doi.org/10.1200/jco.2003.03.034.

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Purpose: Lonidamine (LND) can enhance the activity of anthracyclines in patients with metastatic breast cancer. A multicenter, prospective, randomized trial was designed to determine whether the association of LND with high-dose epirubicin plus cyclophosphamide (EC) could improve disease-free survival (DFS) in patients with early breast cancer (BC) compared with EC alone. Granulocyte colony-stimulating factor (G-CSF) was added to maintain the EC dose-intensity. Patients and Methods: From October 1991 to April 1994, 506 patients with stage I/II BC were randomly assigned to four groups: (A) epirubicin 120 mg/m2 and cyclophosphamide 600 mg/m2 administered intravenously on day 1 every 21 days for four cycles (124 patients); (B) EC plus LND 450 mg/d administered orally (125 patients); (C) EC plus G-CSF administered subcutaneously (129 patients); (D) EC plus LND plus G-CSF (128 patients). Results: Median follow-up was 55 months. Five-year DFS rate was similar for LND (B+D groups; 69.6%) versus non-LND arms (A+C groups; 70.3%) and G-CSF (C+D groups; 67.2%) versus non–G-CSF arms (A+B groups; 72.9%). Five-year overall survival (OS) was comparable in LND (79.1%) versus non-LND arms (81.3%) and in G-CSF (80.6%) versus non–G-CSF arms (79.6%). DFS and OS distributions in LND and G-CSF arms did not change according to tumor size, node, receptor, and menopausal status. G-CSF dramatically reduced hematologic toxicity without having a significant impact on dose-intensity (98.1% v 95.5% for C+D and A+B groups, respectively). Conclusion: EC is active and well tolerated in patients with early breast cancer. The addition of LND or G-CSF does not improve DFS or OS.

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Zhu, Liyan, Sang-Hee Shin, Roshan Payapulli, Taiki Machii, Mizuki Motoyoshi, Noriharu Suematsu, Nick M. Ridler e Stepan Lucyszyn. "Erratum Erratum to “3-D Printed Rectangular Waveguide 123–129 GHz Packaging for Commercial CMOS RFICs”". IEEE Microwave and Wireless Technology Letters 33, n. 2 (febbraio 2023): 236. http://dx.doi.org/10.1109/lmwt.2023.3235599.

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Kakoschke, Andreas. "DF wie DEFVNCTVS. Zu zwei Grabinschriften aus der nordwestlichen Germania superior". Frankfurter elektronische Rundschau zur Altertumskunde, n. 25 (28 luglio 2016): 28–38. http://dx.doi.org/10.21248/fera.25.106.

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Zusammenfassung:In den römischen Grabinschriften 2. N. Nr.129 (Mittelstrimmig) und CIL XIII 6202 (Schwarzerden) sollte D•F zu d(e)f(unctis) bzw. d(e)f(uncto) aufgelöst werden und nicht zu D(ecimi) f(ilio) bzw. d(efuncto) f(ecit). Die Wendung defunctus kommt im gallisch-germanischen Raum vor allem in Bordeaux/Burdigala und im Gebiet von Trier/Augusta Treverorum vor.Abstract:In two stone inscriptions from Mittelstrimmig (2. N. Nr.129) and Schwarzerden (CIL XIII 6202) dating to the Roman period, one should read D•F as d(e)f(unctis) respectively d(e)f(uncto), instead of D(ecimi) f(ilio) respectively d(efuncto) f(ecit). Defunctus is known in the gallo-germanic provinces especially in Bordeaux/Burdigala and in the area of Trier/Augusta Treverorum.

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Du, Xianjin, Dan Tian, Jie Wei, Chen Yan, Peng Hu, Xu Wu e Wenbin Yang. "MEG3 Alleviated LPS-Induced Intestinal Injury in Sepsis by Modulating miR-129-5p and Surfactant Protein D". Mediators of Inflammation 2020 (22 gennaio 2020): 1–11. http://dx.doi.org/10.1155/2020/8232734.

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Sepsis and intestinal injury triggered by sepsis are common in intensive care units, which can contribute to a high mortality. lncRNAs can modulate gene expression, and they are closely involved in multiple diseases, including sepsis. In our present study, we investigated the biological function of MEG3 in sepsis, especially during the intestinal injury. Currently, we observed that in LPS-induced sepsis mouse models, the intestinal injury was triggered. Meanwhile, we reported that MEG3 was greatly decreased in vivo, with an increase of miR-129-5p and inhibition of SP-D. Then, MEG3 was overexpressed, and we found that its overexpression repressed the intestinal injury via downregulating miR-129-5p in sepsis mice. Moreover, TNF-α and IL-6 expression was elevated in intestinal tissues compared to the control groups. MEG3 restrained the activation of TNF-α and IL-6, in sepsis models. Subsequently, to induce the inflammatory injury of sepsis, human colorectal Caco2 cells were treated with 10 ng/ml LPS. 10 ng/ml LPS significantly inhibited Caco2 cell proliferation and increased the apoptosis. Additionally, MEG3 was decreased whereas miR-129-5p was obviously increased in Caco2 cells incubated with LPS. Interestingly, we showed that MEG3 repressed cell apoptosis partly and enhanced Caco2 cell proliferation. miR-129-5p overexpression could reverse the effect of MEG3 in vitro. Previously, we proved SP-D was reduced in sepsis and it depressed the intestinal injury in vivo. Finally, the correlation among MEG3, miR-129-5p, and SP-D was predicted and confirmed in our investigation. These findings indicated that MEG3 might be a potential target for intestinal damage caused by sepsis via regulating miR-129-5p and SP-D.

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Aksan, A., K. Böttger, N. Hein, Y. Caicedo-Zea, I. Diehl, C. Schumann, F. P. Armbruster e J. M. Stein. "P431 Vitamin D binding protein in the limelight: IBD-related inflammation and circulating levels of vitamin D binding protein, total, free and bioavailable 25-hydroxyvitamin D". Journal of Crohn's and Colitis 14, Supplement_1 (gennaio 2020): S393. http://dx.doi.org/10.1093/ecco-jcc/jjz203.560.

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Abstract Background Vitamin D deficiency occurs frequently in patients with Crohn’s disease (CD) and ulcerative colitis (UC). While recent cohort studies support an association of vitamin D with important clinical parameters and outcomes in IBD, the complex interplay of inflammation with vitamin D metabolism in IBD poses a viscious circle. We sought to further illucidate the relation between inflammation and different vitamin D parameters. To the best our knowledge, this was the first study to focus on the relationship between vitamin D binding protein (VDBP), circulating total, free, and bioavailable 25-hydroxyvitamin D (25(OH)D), and inflammation, in adult IBD patients. Methods This was a comparative, single-centred, cross-sectional study in patients with IBD aged 18–65 years. Full blood count, transferrin, albumin and hsCRP were determined by standard methods. The presence/absence of inflammation was assessed based on serum hsCRP levels (cutoff <5mg/l). VDBP levels were determined by ELISA, and 25(OH)D by LCMS. Free and bioavailable vitamin D levels were calculated using the validated formula. IBM SPSS version 25.0 was used for statistical analysis. Results In total, 129 subjects with IBD (70 male/59 female; 82 CD/47 UC; mean age 41.7 ± 12.6 years) were enrolled. Of these, 38/129 had inflammation (19 m/19 f; 26 CD/12 UC; 39.6 ± 12.9 years) while 91/129 had no inflammation (40 m/51 f; 56 CD/35 UC; 42.5 ± 12.5 years). Subjects with disease activity had significantly higher leukocyte, erythrocyte sedimentation rate (ESR) and hsCRP, but lower transferrin, transferrin saturation (TSAT) and albumin levels than those without inflammation (p < 0.05). Average serum levels of 25(OH)D (24.6[6.8–54.8] vs. 26.4[5.0–74.4]ng/ml), free 25(OH)D (5.9[1.3–13.3] vs. 1.0[1.0–21.4]ng/ml) and bioavailable 25(OH)D(2.3 [0.1–4.7] vs. 2.4[0.5–19.5]ng/ml) were similar in patients with vs. without inflammation (p > 0.05). However, VDBP levels were significantly higher in inflammatory conditions (359.6[252.2–530.6] mg/l vs. 327.4[183.5–560.3]mg/l; p < 0.05) and showed a positive correlation with CRP levels (0.293, p < 0.001). Ratio of free/total 25(OH)D correlated negatively with CRP levels (−0.282, p = 0.002). Conclusion High levels of circulating VDBP were associated with inflammatory activity. Moreover, free/total 25(OH)D ratio was inversely associated with inflammation. Other vitamin D parameters including total, free and bioavailable 25(OH)D showed no association with inflammation. These findings suggest that VDBP may play a bigger role than thought as a modulator of vitamin D and inflammation, and that simultaneous detection and investigation of plasma VDBP may provide additional insights into this complex interaction.

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Rondon-Berrios, Helbert, Srijan Tandukar, Maria K. Mor, Evan C. Ray, Filitsa H. Bender, Thomas R. Kleyman e Steven D. Weisbord. "Urea for the Treatment of Hyponatremia". Clinical Journal of the American Society of Nephrology 13, n. 11 (4 settembre 2018): 1627–32. http://dx.doi.org/10.2215/cjn.04020318.

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Background and objectivesCurrent therapies for hyponatremia have variable effectiveness and tolerability, and in certain instances, they are very expensive. We examined the effectiveness, safety, and tolerability of urea for the treatment of inpatient hyponatremia.Design, setting, participants, & measurementsWe identified all patients hospitalized at the University of Pittsburgh Medical Center between July 2016 and August 2017 with hyponatremia (plasma sodium <135 mEq/L) who received urea, including a subgroup of patients who received urea as the sole drug therapy for hyponatremia (urea-only treated). We matched urea only–treated patients to a group of patients with hyponatremia who did not receive urea (urea untreated) and compared changes in plasma sodium at 24 hours and the end of therapy as well as the proportion of patients who achieved plasma sodium ≥135 mEq/L. We abstracted data on adverse events and reported side effects of urea.ResultsFifty-eight patients received urea (7.5–90 g/d) over a median of 4.5 (interquartile range, 3–8) days and showed an increase in plasma sodium from 124 mEq/L (interquartile range, 122–126) to 131 mEq/L (interquartile range, 127–134; P<0.001). Among 12 urea only–treated patients, plasma sodium increased from 125 mEq/L (interquartile range, 122–127) to 131 mEq/L (interquartile range, 129–136; P=0.001) by the end of urea therapy. There was a larger increase in plasma sodium at 24 hours in urea only–treated patients compared with urea-untreated patients (2.5 mEq/L; interquartile range, 0–4.5 versus −0.5 mEq/L; interquartile range, −2.5 to 1.5; P=0.04), with no difference in change in plasma sodium by the end of therapy (6 mEq/L; interquartile range, 3.5–10 versus 5.5 mEq/L; interquartile range, 3–7.5; P=0.51). A greater proportion of urea only–treated patients achieved normonatremia, but this difference was not statistically significant (33% versus 8%; P=0.08). No patients experienced overly rapid correction of plasma sodium, and no serious adverse events were reported.ConclusionsUrea seems effective and safe for the treatment of inpatient hyponatremia, and it is well tolerated.

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GA, Chillo, Jeongho LEE, Won Hee LEE e Kiyun YU. "New POI Construction with Street-Level Imagery". IEICE Transactions on Information and Systems E96.D, n. 1 (2013): 129–33. http://dx.doi.org/10.1587/transinf.e96.d.129.

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Yanagisawa, Shinya, Masashi Kimura, Keiichi Hagiwara, Atsuko Ogoshi, Tomotaka Yoneyama, Hiroaki Omae, Ryosuke Miyamoto e Hirotaka Chikuda. "A steep coronal graft bending angle is associated with bone tunnel enlargement of the posterolateral bundle after anterior cruciate ligament reconstruction". Journal of Orthopaedic Surgery 28, n. 1 (12 dicembre 2019): 230949901988881. http://dx.doi.org/10.1177/2309499019888811.

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Purpose: The correlation between the graft bending angle (GBA) of the anteromedial bundle and posterolateral bundle after anterior cruciate ligament reconstruction (ACLR) and postoperative tunnel enlargement was evaluated. Methods: Two hundred fifty-eight patients (137 males, 121 females; mean age 27.3 years) who had undergone double-bundle ACLR were included. Computed tomographic scans of the operated knee were obtained at 2 weeks and 6 months postoperatively. The area of the tunnel aperture for femoral anteromedial tunnel (FAMT) and femoral posterolateral tunnel (FPLT) was measured; the area at 2 weeks after ACLR was subtracted from the area at 6 months after ACLR and then divided by the area at 2 weeks after ACLR. The femoral tunnel angles were obtained with Cobb angle measurements. The femoral tunnel angle in the coronal plane was measured relative to the tibial plateau (coronal GBA). On the median value, the patients were divided into two groups in each of FAMT and FPLT; those with a coronal GBA of FAMT of ≥27° were classified as group A, while those with a coronal GBA of <27° were classified as group B, those with a coronal GBA of FPLT of ≥23° were classified as group C, while those with a coronal GBA of<23° were classified as group D. Results: Group A included 129 knees, while group B included 129 knees. Groups A and B did not significantly differ regarding FAMT enlargement. Group C included 133 knees, while group D included 125 knees. The percentage of FPLT enlargement in group C was significantly smaller than that in group D ( p = 0.001). Conclusions: A steep coronal GBA of the FPLT after ACLR results in greater FPLT enlargement. The present findings suggest that surgeons should avoid creating a steep GBA of the FPLT in the outside-in technique.

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Thapa, Arati, Mukesh Karki e Aradhana Thapa. "Vitamin-D Deficiency among Psychiatric Outpatients Attending Tertiary Care Hospital". Journal of College of Medical Sciences-Nepal 16, n. 4 (31 dicembre 2020): 195–200. http://dx.doi.org/10.3126/jcmsn.v16i4.34460.

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Abstract Background: Vitamin D deficiency is associated with various physical and mental illness. This study aimed to estimate the prevalence of vitamin D deficiency among patients with psychiatric illness who visited Psychiatry outpatient department of College of Medical Sciences and Teaching Hospital, Chitwan, Nepal and investigate association of vitamin D with clinical characteristics and psychiatric illness. Methods: A total of 129 who attended Psychiatry OPD of College of Medical Sciences and Teaching Hospital were enrolled over a period of 4 months after taking informed written consent. Psychiatric diagnoses were established by attending psychiatrists as part of the routine assessment using ICD 10/DCR criteria. Serum vitamin D was assessed by standard method. Data was analyzed using SPSS. Results: Among 129 participants, one hundred and seven patients (82.9%) showed vitamin D level below normal range. Thirty one (24%) had vitamin D deficiency, seventy six (58.9%) had vitamin D insufficiency and twenty two (17.1%) had normal vitamin D level. The mean level of vitamin D was 24.11± 10.19. However, there was no significant association noted between vitamin D state and socio demographic profile and psychiatric illness. Conclusions: We have found a high percentage of vitamin D deficiency among psychiatric patients in our study. Thus, screening for vitamin D deficiency should be considered as an important part of assessment of patients with major psychiatric illnesses.

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Yang, P., K. Zhao, Y. Yin, J. G. Wan e J. S. Zhu. "Magnetoelectric effect in magnetostrictive/piezoelectric laminate composite Terfenol-D∕LiNbO3 [(zxtw)−129°∕30°]". Applied Physics Letters 88, n. 17 (24 aprile 2006): 172903. http://dx.doi.org/10.1063/1.2198486.

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Ramis Barceló, Rafael. "Stefania Zanardi, Umanesimo e umanesimi. Saggio introduttivo alla storiografia di Eugenio Garin, Milano, Franco Angeli, 2019",. Anales del Seminario de Historia de la Filosofía 38, n. 2 (26 aprile 2021): 371–72. http://dx.doi.org/10.5209/ashf.72332.

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James, Eleanor, Ruth Dobson, Jens Kuhle, David Baker, Gavin Giovannoni e Sreeram V. Ramagopalan. "The effect of vitamin D-related interventions on multiple sclerosis relapses: a meta-analysis". Multiple Sclerosis Journal 19, n. 12 (22 maggio 2013): 1571–79. http://dx.doi.org/10.1177/1352458513489756.

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Observational studies have shown an association between lower vitamin D levels and higher risk of relapse among people with multiple sclerosis (MS). This has raised interest in potential clinical benefits of vitamin D supplementation in the management of MS. The objectives were to examine the effect of vitamin D based interventions on the relative risk of relapse in MS. Any randomised controlled trial assessing the effect on the relative risk of relapse of any formulation or dose of vitamin D, in participants with MS, was eligible. The inverse variance with random effects model in Review Manager 5.1 was used to calculate the odds ratio of relapses in high dose vitamin D treated patients vs. controls. Five studies were published as of September 2012, yielding a total of 129 high-dose vitamin D-treated patients and 125 controls. We found no significant association between high-dose vitamin D treatment and risk of MS relapse (OR 0.98, 95% CI 0.45–2.16). In conclusion, although no significant association between high-dose vitamin D treatment and risk of MS relapses was found, the studies were limited by several methodological limitations. Further larger, more prolonged studies are merited.

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Elfaki, Imadeldin, Rashid Mir, Faisel M. Abu Duhier, Maeidh A. Alotaibi, Adel Ibrahim Alalawy, Jameel Barnawi, Abdullatif Taha Babakr et al. "Clinical Implications of MiR128, Angiotensin I Converting Enzyme and Vascular Endothelial Growth Factor Gene Abnormalities and Their Association with T2D". Current Issues in Molecular Biology 43, n. 3 (2 novembre 2021): 1859–75. http://dx.doi.org/10.3390/cimb43030130.

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Type 2 DM (T2D) results from the interaction of the genetic and environmental risk factors. Vascular endothelial growth factor (VEGF), angiotensin I-converting enzyme (ACE), and MicroRNAs (MiRNAs) are involved in important physiological processes. Gene variations in VEGF, ACE and MiRNA genes are associated with diseases. In this study we investigated the associations of the VEGF-2578 C/A (rs699947), VEGF-2549 insertion/deletion (I/D), and ACE I/D rs4646994 and Mir128a (rs11888095) gene variations with T2D using the amplification refractory mutation system PCR (ARMS-PCR) and mutation specific PCR (MSP). We screened 122 T2D cases and 126 healthy controls (HCs) for the rs699947, and 133 T2D cases and 133 HCs for the VEGF I/D polymorphism. For the ACE I/D we screened 152 cases and 150 HCs, and we screened 129 cases and 112 HCs for the Mir128a (rs11888095). The results showed that the CA genotype of the VEGF rs699947 and D allele of the VEGF I/D polymorphisms were associated with T2D with OR =2.01, p-value = 0.011, and OR = 2.42, p-value = 0.010, respectively. The result indicated the D allele of the ACE ID was protective against T2D with OR = 0.10, p-value = 0.0001, whereas the TC genotype and the T allele of the Mir128a (rs11888095) were associated with increased risk to T2D with OR = 3.16, p-value = 0.0001, and OR = 1.68, p-value = 0.01, respectively. We conclude that the VEGF (rs699947), VEGF I/D and Mir128a (rs11888095) are potential risk loci for T2D, and that the D allele of the ACE ID polymorphism may be protective against T2D. These results help in identification and stratification for the individuals that at risk for T2D. However, future well-designed studies in different populations and with larger sample sizes are required. Moreover, studies to examine the effects of these polymorphisms on VEGF and ACE proteins are recommended.

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Galindo-Murillo, Rodrigo, e Thomas E. Cheatham III. "129 Convergence and reproducibility of the DNA duplex d(GCACGAACGAACGAACGC) using molecular dynamics simulations". Journal of Biomolecular Structure and Dynamics 33, sup1 (18 maggio 2015): 83–84. http://dx.doi.org/10.1080/07391102.2015.1032762.

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HARMS, L., D. EYLES, J. MCGRATH, A. MACKAYSIM e T. BURNE. "Developmental vitamin D deficiency alters adult behaviour in 129/SvJ and C57BL/6J mice". Behavioural Brain Research 187, n. 2 (5 marzo 2008): 343–50. http://dx.doi.org/10.1016/j.bbr.2007.09.032.

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Grosu, A. L., H. J. Feldmann, W. Weber, M. Schwaiger e M. Molls. "129 The impact of I-123-alpha-methyl-tyrosine spect in the planning of 3-D radiation treatment of brain gliomas". International Journal of Radiation Oncology*Biology*Physics 45, n. 3 (gennaio 1999): 213–14. http://dx.doi.org/10.1016/s0360-3016(99)90147-5.

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24

Chong, Joaquin A., Uttara C. Samarakoon e James E. Faust. "Effects of Daily Light Integral and Canopy Density on Shoot Growth and Development in a Poinsettia (Euphorbia pulcherrima Willd. ex. Klotsch) Stock Plant Canopy". HortScience 49, n. 1 (gennaio 2014): 51–54. http://dx.doi.org/10.21273/hortsci.49.1.51.

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Poinsettia stock plants consist of a dense canopy of competing shoots, and the growth and development of these individual shoots have not been previously quantified. The effects of air temperature, daily light integral (DLI), and canopy density (CD) were investigated on poinsettia (Euphorbia pulcherrima Willd. ex. Klotsch) ‘Freedom Red’ shoot development in a stock plant canopy. Plants were grown at two constant temperatures (20.3 or 25.7 °C), five CD (43, 86, 129, 172, or 215 shoots/m2), and three DLI treatments (2.6, 4.4, or 7.7 mol·m−2.d−1 for the September planting and 4.0, 6.0, or 10.6 mol·m−2.d−1 for the January planting). Shoot position at the final data collection was used to assign shoots to different levels within the canopy; Level 1 = the four highest shoots, Level 2 = the next four highest shoots, and so forth for Levels 3, 4, and 5. Temperature did not significantly affect leaf unfolding rate (LUR), shoot fresh mass (FM), or shoot caliper, whereas DLI and CD affected shoot growth and development. LUR and FM increased as DLI increased from 2.6 to 10.6 mol·m−2.d−1, whereas LUR and FM decreased on the uppermost shoots in the canopy, e.g., Level 1 shoots, as CD increased from 43 to 129 shoots/m2. Therefore, higher CD required higher DLI to achieve similar LUR and FM. Shoot caliper on Level 1 shoots increased from 6.3 to 7.4 mm as CD decreased from 129 to 43 shoots/m2; and shoot caliper increased from 5.8 to 7.6 mm as DLI increased from 4.0 to 10.6 mol·m−2.d−1. The DLI environment needs to be managed to accommodate greater CD, to sustain growth and development of individual shoots within the canopy of poinsettia stock plants.

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Laknaur, Archana, Sangeeta Nair, Jeff Reese, Ayman Al-Hendy e Chandrasekhar Thota. "129: Vitamin D delays lipopolysaccharide induced preterm delivery in a vitamin D deficient mouse model by preventing decline in progesterone levels". American Journal of Obstetrics and Gynecology 212, n. 1 (gennaio 2015): S81. http://dx.doi.org/10.1016/j.ajog.2014.10.175.

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Lehmann, Antje, Helmut Prosch, Sonja Zehetmayer, Maximilian Robert Gysan, Dominik Bernitzky, Karin Vonbank, Marco Idzko e Daniela Gompelmann. "Impact of persistent D-dimer elevation following recovery from COVID-19". PLOS ONE 16, n. 10 (28 ottobre 2021): e0258351. http://dx.doi.org/10.1371/journal.pone.0258351.

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Background Elevated D-dimer is known as predictor for severity of SARS-CoV2-infection. Increased D-dimer is associated with thromboembolic complications, but it is also a direct consequence of the acute lung injury seen in COVID-19 pneumonia. Objectives To evaluate the rate of persistent elevated D-dimer and its association with thromboembolic complications and persistent ground glass opacities (GGO) after recovery from COVID-19. Methods In this post hoc analysis of a prospective multicenter trial, patients underwent blood sampling, measurement of diffusion capacity, blood gas analysis, and multidetector computed tomography (MDCT) scan following COVID-19. In case of increased D-dimer (>0,5 μg/ml), an additional contrast medium-enhanced CT was performed in absence of contraindications. Results were compared between patients with persistent D-dimer elevation and patients with normal D-dimer level. Results 129 patients (median age 48.8 years; range 19–91 years) underwent D-Dimer assessment after a median (IQR) of 94 days (64–130) following COVID-19. D-dimer elevation was found in 15% (19/129) and was significantly more common in patients who had experienced a severe SARS-CoV2 infection that had required hospitalisation compared to patients with mild disease (p = 0.049). Contrast-medium CT (n = 15) revealed an acute pulmonary embolism in one patient and CTEPH in another patient. A significant lower mean pO2 (p = 0.015) and AaDO2 (p = 0.043) were observed in patients with persistent D-Dimer elevation, but the rate of GGO were similar in both patient groups (p = 0.33). Conclusion In 15% of the patients recovered from COVID-19, persistent D-dimer elevation was observed after a median of 3 months following COVID-19. These patients had experienced a more severe COVID and still presented more frequently a lower mean pO2 and AaDO2.

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Hocaoglu, Elif, Ercan Inci e Meltem Vural. "Could Computed Tomography Hounsfield Unit Values of Lumbar Vertebrae Detect Osteoporosis?" Current Medical Imaging Formerly Current Medical Imaging Reviews 17, n. 8 (24 agosto 2021): 988–95. http://dx.doi.org/10.2174/1573405617999210112193545.

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Background: Dual-energy X-ray absorptiometry (DEXA) scanning has several disadvantages determining osteoporosis, especially for the degenerative spine. Introduction: This study aims to determine spinal osteoporosis in patients suffering from lumbar degenerative disease using computed tomography (CT). Methods: A total of 547 subjects that underwent DEXA and abdominal CT within a period of three months were examined retrospectively and separated into groups based on lumbar degenerative alteration on the CT scan. The subjects that showed degenerative severity at L1–L4, in at least two levels, were graded and placed in the degenerative group (Group D, n=350). In contrast, the other subjects constituted the control group (Group C, n=197). The Hounsfield unit (HU) of the vertebral body trabecular bone, the T-score, and bone mineral density (BMD) of L1–L4 and hips were determined from the CT images. CT-HU parameters for osteoporosis acquired from the control group were used to ascertain undiagnosed osteoporosis. Results: The CT-HU was positively correlated with T-score and lumbar BMD for both groups (P<0.001), while the L1–L4 correlation was higher in Group C than in Group D. Based on linear regression, the T-score and CT-HU for L1-L4 osteoporosis were 129, 136, 129 and 120 HU, respectively in Group C. Undiagnosed spinal osteoporosis was greater in Group D compared to the controls (44.2% vs. 9.6%, respectively) based on the CT-HU thresholds. Conclusion: Lumbar spine degeneration can augment BMD and T-score, resulting in the underestimation of lumbar osteoporosis. The osteoporosis threshold determined by CT-HU may be a valuable technique to determine undiagnosed spinal osteoporosis.

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Zimmer, Stefan, Hanna Zuralski, Mozhgan Bizhang, Thomas Ostermann e Claudia R. Barthel. "Anterior Open Bite In 27 Months Old Children after Use of a Novel Pacifier – A Cohort Study". Journal of Clinical Pediatric Dentistry 40, n. 4 (1 ottobre 2016): 328–33. http://dx.doi.org/10.17796/1053-4628-40.4.328.

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Objectives: The aim of the present cohort study was to evaluate the influence of a novel pacifier on the first formation of malocclusion, the anterior open bite in children. Study design: 129 newborn children whose parents had decided to use pacifiers were randomly attributed to two experimental groups (D=Dentistar, n=56, Novatex, Pattensen, Germany; N=NUK, n=73, Mapa, Zeven, Germany). Children (n=42) who did not use a pacifier were not randomized and served as reference (C). Primary outcome was the presence of anterior open bite. It was hypothesized that D would result in lower incidence when compared to N. At the age of 27 months the children were examined with respect to anterior open bite. Fisher's exact test served to detect significant differences between groups D and N (SPSS 22.0). Results: 121 children with a mean age of 26.7 months were included in the final analysis (D: n=45; N: n=42; C: n=34). In group D three children (6.7%) showed an anterior open bite. The respective values were 21 (50.0%) for N and 0 for C. The results for group D compared to N were significantly different (chi2-test, p<0.001). Conclusion: In comparison to a commonly used pacifier the novel one causes significantly less anterior open bites.

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Edwards, S. R., J. D. Hobbs e J. T. Mulliniks. "High milk production decreases cow-calf productivity within a highly available feed resource environment". Translational Animal Science 1, n. 1 (1 gennaio 2017): 54–59. http://dx.doi.org/10.2527/tas2016.0006.

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Abstract The beef cattle industry tends to focus on selecting production traits with the purpose of maximizing cow-calf performance. One such trait is milking ability, which is considered the primary influence on weaning weight of the calf. Therefore, the objective of this study was to determine the effect of actual milk yield on reproductive performance, circulating blood metabolites, and calf performance in beef cows in the Southeastern US. Over a 2 yr period, data were collected from 237, 3- to 9-yr-old Angus-sired beef cows on 3 research stations in Tennessee. On approximately d 58 and 129 postpartum, 24-hr milk production was measured with a modified weigh-suckle-weigh technique using a milking machine. Subsamples of milk were collected for analysis of milk components. Milk yield data were used to retrospectively classify cows on actual milk yield as High ( ≥ 10 kg/d), Mod (8 to 9 kg/d), or Low ( < 8 kg/d). Cow body weight (BW) and body condition score (BCS) were collected weekly at each location through breeding. Calf BW was recorded at birth, mid-weight at d 58, and weaning. At d 58 and 129 of postpartum, milk yields were different (P < 0.001) among the treatment groups. Cow BW during the entire study were not different (P ≥ 0.22) with increasing milk yield. Timed-AI pregnancy rate were the lowest (P = 0.02) in the High milk producing cows with no difference (P > 0.05) between Low and Mod milk cows. In addition, overall pregnancy rate continued to be the lowest (P = 0.04) in High milk producing cows with the greatest pregnancy rate in Mod milk cows. Calf mid-weight at ∼d 58 was increased (P < 0.001) in calves from Mod and High milking cows. However, calf BW at weaning was not different (P = 0.22) among calves from different milk treatment groups. Results from this study suggest that even in management systems that modify the grazing environments with harvested feedstuffs, high milk production decreases reproductive efficiency. In addition, increasing milk production up to d 129 postpartum did not result in increased calf BW at weaning, indicating that the genetic potential for calf BW at weaning could not be improved with increased genetic potential for milk production.

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Olie, JP, KP Gunn e E. Katz. "A double-blind placebo-controlled multicentre study of sertraline in the acute and continuation treatment of major depression". European Psychiatry 12, n. 1 (1997): 34–41. http://dx.doi.org/10.1016/s0924-9338(97)86377-8.

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SummaryIn a double-blind multicentre study of outpatients with DSM-III-R major depressive disorder, 129 sertraline and 129 placebo patients were evaluated over a 6-week period. Sertraline exhibited a significantly greater (P < 0.001) antidepressant effect compared to placebo as measured by the HAM-D, MADRS, CGI-S and CGI-I. In the subset of patients with severe depression (baseline HAM-D ≥ 25), sertraline was also significantly more effective than placebo (P < 0.05). Side effects were more commonly reported in sertraline (59%) compared to placebo (38%) patients; the most common being nausea, headache and insomnia. A subset of 107 patients (66 sertraline; 41 placebo) who were defined as responders (CGI-I of 1 or 2) after 6 weeks treatment were entered into a 20-week continuation phase. In this responder subset, there was continuing improvement in both groups of patients, but with no significant differences in mean HAM-D or MADRS between the groups. However, a higher number of sertraline patients were associated with a persistent pattern of improvement relative to placebo (P < 0.05). The incidence of side effects was similar in sertraline (52%) and placebo (49%) treated patients in the continuation period.

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Nieto, R., A. Miranda, M. A. García e J. F. Aguilera. "The effect of dietary protein content and feeding level on the rate of protein deposition and energy utilization in growing Iberian pigs from 15 to 50kg body weight". British Journal of Nutrition 88, n. 1 (luglio 2002): 39–49. http://dx.doi.org/10.1079/bjn2002591.

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The effects of dietary protein content and feeding level on the utilization of metabolizable energy (ME) and on the rates of gain, protein and fat deposition have been studied in seventy-two Iberian pigs growing from 15 to 50 kg body weight (BW) by means of comparative slaughter experiments. The animals were fed on six diets providing 223, 192, 175, 156, 129 and 101 g crude ideal protein (N×6·25; CP)/kg DM and 14·64, 14·14, 14·37, 14·80, 15·36 and 15·53 MJ ME/kg DM respectively. Each diet was offered at three levels of feeding: 0·60, 0·80 and 0·95×ad libitum intake. Protein deposition (PD) increased significantly (P<0·01) with each decrease in dietary CP content and reached a maximum value (74·0 g) when the diet providing 129 g CP/kg DM (6·86 g digestible ideal protein/MJ ME) was offered at the highest feeding level. This feeding regimen resulted in average values for live-weight gain and retained energy (RE) of 559 g/d and 10·9 MJ/d respectively. RE increased significantly (P<0·001) from 480 to 626 kJ/kg BW0·75 with each decrease in dietary CP content from 192 to 129 g/kg DM. Raising the level of feed intake led to significant linear increases in PD and RE irrespective of the diet fed (P<0·001). When diets approaching an adequate supply of CP were given, the net efficiency of use of ME for growth (kw) and the maintenance energy requirements were 58·2 % and 422 kJ/kg BW0·75 per d respectively.

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Hashim, G., A. A. Vandenbark, D. P. Gold, T. Diamanduros e H. Offner. "T cell lines specific for an immunodominant epitope of human basic protein define an encephalitogenic determinant for experimental autoimmune encephalomyelitis-resistant LOU/M rats." Journal of Immunology 146, n. 2 (15 gennaio 1991): 515–20. http://dx.doi.org/10.4049/jimmunol.146.2.515.

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Abstract The LOU/M rat (RT-1w) haplotype, although resistant to an encephalitogenic challenge of guinea pig myelin basic protein (Gp-BP)/CFA and unresponsive to Gp-BP, responded strongly to human (Hu)-BP. Both T cell and antibody responses focused on the 110-129 determinant of Hu-BP, and T cells specific for this epitope transferred clinical and histologic experimental autoimmune encephalomyelitis (EAE) to naive LOU/M rats. Moreover, EAE could be induced actively with Hu-BP and a synthetic Hu-S110-129 peptide in CFA, but only with co-immunomodulation by pertussis toxin or cyclophosphamide. Analysis of TCR V region genes revealed the predominant use of the V beta 8.5-J beta 2.3 gene combination, with extensive N region additions to both D beta 1 and D beta 2. These results define the Hu-BP 110-129 peptide sequence as the major encephalitogenic epitope for the LOU/M strain of rat previously considered resistant to EAE, and support the idea that the encephalitogenic property of BP and other CNS Ag for a given MHC is encompassed within immunodominant T cell epitopes. Furthermore, the TCR sequence data indicate the predominant use of a different V beta 8 subfamily member (V beta 8.5) than the V beta 8.2 gene used preferentially by several other rat strains and the PL/J mouse in the T cell response to BP.

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Walton, Jeffrey H. "A Review of ¹²⁹Xe NMR as a Probe of Polymer Morphology". Engineering Plastics 2, n. 1 (gennaio 1994): 147823919400200. http://dx.doi.org/10.1177/147823919400200105.

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129 Xe NMR is a new tool for probing the morphology of polymers and polymer blends. Recent developments of the NMR of 129 Xe gas dissolved in polymers are reviewed. This technique yields information on polymer morphology via the NMR lineshape and the isotropic chemical shift and their temperature dependencies. Polymer glass transition temperatures are plainly evident. The miscibility of polymer blends is easily determined and thus phase diagrams may be mapped out. Of particular use is the potential ability to measure domain sizes in immiscible polymer blends by 2-D NMR techniques. Domain sizes from 0.1 micrometers to 25 micrometers should easily be measurable.

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Walton, Jeffrey H. "A Review of ¹²⁹Xe NMR as a Probe of Polymer Morphology". Polymers and Polymer Composites 2, n. 1 (gennaio 1994): 35–41. http://dx.doi.org/10.1177/096739119400200105.

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Abstract (sommario):

129 Xe NMR is a new tool for probing the morphology of polymers and polymer blends. Recent developments of the NMR of 129 Xe gas dissolved in polymers are reviewed. This technique yields information on polymer morphology via the NMR lineshape and the isotropic chemical shift and their temperature dependencies. Polymer glass transition temperatures are plainly evident. The miscibility of polymer blends is easily determined and thus phase diagrams may be mapped out. Of particular use is the potential ability to measure domain sizes in immiscible polymer blends by 2-D NMR techniques. Domain sizes from 0.1 micrometers to 25 micrometers should easily be measurable.

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Moya, Manuel, Isabel Ballester, Maria José Campello e Cortés Ernesto. "129 INCREASED CONCENTRATION OF 25-HYDROXYVITAMIN D (250) AND 1,25 DIHYDROXYVITAMIN D (1,25) RECEPTORS IN KIDNEYS OF RATS TREATED WITH PHENOBARBITAL (PB)". Pediatric Research 30, n. 6 (dicembre 1991): 649. http://dx.doi.org/10.1203/00006450-199112000-00159.

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Carr, Anitra C., Helen Lunt, Nicholas J. Wareham e Phyo K. Myint. "Estimating Vitamin C Intake Requirements in Diabetes Mellitus: Analysis of NHANES 2017–2018 and EPIC-Norfolk Cohorts". Antioxidants 12, n. 10 (15 ottobre 2023): 1863. http://dx.doi.org/10.3390/antiox12101863.

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Abstract (sommario):

Vitamin C is an essential enzyme cofactor and antioxidant with pleiotropic roles in human physiology. Circulating vitamin C concentrations are lower in people with diabetes mellitus, suggesting a higher dietary requirement for the vitamin. We interrogated the NHANES 2017–2018 and EPIC-Norfolk datasets to compare vitamin C requirements between those with and without diabetes mellitus using dose–concentration relationships fitted with sigmoidal (four-parameter logistic) curves. The NHANES cohort (n = 2828 non-supplementing adults) comprised 488 (17%) participants with diabetes (self-reported or HbA1c ≥ 6.5%). The participants with diabetes had a lower vitamin C status (median [IQR]) than those without (38 [17, 52] µmol/L vs. 44 [25, 61] µmol/L, p < 0.0001), despite comparable dietary intakes between the two groups (51 [26, 93] mg/d vs. 53 [24, 104] mg/d, p = 0.5). Dose–concentration relationships indicated that the group without diabetes reached adequate vitamin C concentrations (50 µmol/L) with an intake of 81 (72, 93) mg/d, whilst those with diabetes required an intake of 166 (126, NA) mg/d. In the EPIC-Norfolk cohort, comprising 20692 non-supplementing adults, 475 (2.3%) had self-reported diabetes at baseline. The EPIC cohort had a lower BMI than the NHANES cohort (26 [24, 28] kg/m2 vs. 29 [25, 34] kg/m2, p < 0.0001). Correspondingly, the EPIC participants without diabetes required a lower vitamin C intake of 64 (63, 65) mg/d while those with diabetes required 129 (104, NA) mg/d to reach adequate circulating vitamin C status. C-reactive protein concentrations were strongly correlated with body weight and BMI and provided a surrogate biomarker for vitamin C requirements. In conclusion, people with diabetes had 1.4 to 1.6 fold higher requirements for vitamin C than those without diabetes. This corresponds to additional daily vitamin C intake requirements of ~30–40 mg for people with diabetes, equating to a total daily intake of at least 125 mg/d.

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Chang, Yen-Ching. "Deep-Learning Estimators for the Hurst Exponent of Two-Dimensional Fractional Brownian Motion". Fractal and Fractional 8, n. 1 (12 gennaio 2024): 50. http://dx.doi.org/10.3390/fractalfract8010050.

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The fractal dimension (D) is a very useful indicator for recognizing images. The fractal dimension increases as the pattern of an image becomes rougher. Therefore, images are frequently described as certain models of fractal geometry. Among the models, two-dimensional fractional Brownian motion (2D FBM) is commonly used because it has specific physical meaning and only contains the finite-valued parameter (a real value from 0 to 1) of the Hurst exponent (H). More usefully, H and D possess the relation of D = 3 − H. The accuracy of the maximum likelihood estimator (MLE) is the best among estimators, but its efficiency is appreciably low. Lately, an efficient MLE for the Hurst exponent was produced to greatly improve its efficiency, but it still incurs much higher computational costs. Therefore, in the paper, we put forward a deep-learning estimator through classification models. The trained deep-learning models for images of 2D FBM not only incur smaller computational costs but also provide smaller mean-squared errors than the efficient MLE, except for size 32 × 32 × 1. In particular, the computational times of the efficient MLE are up to 129, 3090, and 156248 times those of our proposed simple model for sizes 32 × 32 × 1, 64 × 64 × 1, and 128 × 128 × 1.

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Rutledge, Lesley R., e Stacey D. Wetmore. "The assessment of density functionals for DNA–protein stacked and T-shaped complexes". Canadian Journal of Chemistry 88, n. 8 (agosto 2010): 815–30. http://dx.doi.org/10.1139/v10-046.

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The present work uses 129 nucleobase – amino acid CCSD(T)/CBS stacking and T-shaped interaction energies as reference data to test the ability of various density functionals with double-zeta quality basis sets, as well as some semi-empirical and molecular mechanics methods, to accurately describe noncovalent DNA–protein π–π and π+–π interactions. The goal of this work is to identify methods that can be used in hybrid approaches (QM/MM, ONIOM) for large-scale modeling of enzymatic systems involving active-site (substrate) π–π contacts. Our results indicate that AMBER is a more appropriate choice for the lower-level method in hybrid techniques than popular semi-empirical methods (AM1, PM3), and suggest that AMBER accurately describes the π–π interactions found throughout DNA–protein complexes. The M06–2X and PBE-D density functionals were found to provide very promising descriptions of the 129 nucleobase – amino acid interaction energies, which suggests that these may be the most suitable methods for describing high-level regions. Therefore, M06–2X and PBE-D with both the 6–31G(d) and 6–31+G(d,p) basis sets were further examined through potential-energy surface scans to better understand how these techniques describe DNA–protein π–π interactions in both minimum and nonminimum regions of the potential-energy surfaces, which is critical information when modeling enzymatic reaction pathways. Our results suggest that studies of stacked nucleobase – amino acid systems should implement the PBE-D/6–31+G(d,p) method. However, if T-shaped contacts are involved and (or) smaller basis sets must be considered due to limitations in computational resources, then M06–2X/6–31G(d) provides an overall excellent description of both nucleobase – amino acid stacking and T-shaped interactions for a range of DNA–protein π–π and π+–π interactions.

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Vallati, Patricia. "A mid-Cretaceous palynoflora with Tucanopollis crisopolensis from D-129 Formation, San Jorge Gulf Basin, Argentina". Revista Brasileira de Paleontologia 16, n. 2 (30 agosto 2013): 237–44. http://dx.doi.org/10.4072/rbp.2013.2.06.

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Paleologou, Katerina E., Adrian W. Schmid, Carla C. Rospigliosi, Hai-Young Kim, Gonzalo R. Lamberto, Ross A. Fredenburg, Peter T. Lansbury et al. "Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein". Journal of Biological Chemistry 283, n. 24 (14 marzo 2008): 16895–905. http://dx.doi.org/10.1074/jbc.m800747200.

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Baev, V. M., T. Yu Agafonova, O. A. Igumnova e R. Sh Dusakova. "Peculiarities of the systemic hemodynamics reaction and peripheral blood flow to reactive hyperhemia in young women with arterial hypotension". Regional blood circulation and microcirculation 17, n. 3 (30 settembre 2018): 87–91. http://dx.doi.org/10.24884/1682-6655-2018-17-3-87-91.

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The aim of the study was to study a vascular reaction to a test with reactive hyperemia in young women with idiopathic arterial hypotension. 72 women with hypotension (SBP 98 mmHg or less) and 37 women with SBP 120-129 mmHg were examined. A comparative analysis of the response of systemic and peripheral hemodynamics to a test with reactive hyperemia by Celermajer D. In hypotension, occlusion was characterized by an increase in SBP, a change in the diameter and velocity of peripheral arterial and venous blood flow. Thus, the pathological reaction of systemic and peripheral hemodynamics in reactive hyperemia in women with hypotension is a sign of remodeling of the cardiovascular system.

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WEY, MING-TSAI, e LOU-SING KAN. "THE FORMATION AND DETECTION OF TIGHT-TURN IN PYRIMIDINE/PURINE/PYRIMIDINE TYPE DNA TRIPLEXES — NEW FINDINGS ON MOTIFS CC AND TT BY FLUORESCENCE SPECTROSCOPY AT pH 7". Biophysical Reviews and Letters 01, n. 02 (aprile 2006): 119–31. http://dx.doi.org/10.1142/s1793048006000112.

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DNA triplexes with 'tight turns', i.e., sharp turns without any intervening bases, are studied by fluorescence resonance energy transfer process (FRET). The particular turning motifs under consideration are CC and TT imbedded in triplexes (5′- F -( TC )3( CT )3- D + 5′- AGAGAG ) and (5′- F -( CT )3( TC )3- D + 5′- GAGAGA ), where F and D are 6-fluorescein and 4-(4-dimethylaminophenylazo) benzoic acid, respectively. The association equilibrium constants of the above two triplexes ranged from 1.7 × 107 to 2.9 × 104 and 0.75 × 107 to 1.8 × 104 from 10 to 35°C, respectively. The thermodynamic parameters of these two triplexes are comparable (△ H : -46.0 vs. -45.0 Kcal/mol ; △ S : -129 vs -127 cal/mol K ; △ G : -7.5 vs. -7.2 Kcal/mol , respectively). Thus, the stability of the tight-turn triplex with a CC motif is comparable to that with a TT motif, but slightly favored over the latter. This is the first report of a py/pu/py type triplex containing such tight turns studied under pH at 7. The importance is manifested in their stabilities maintained under physiological neutral condition, as opposed to previous studies only obtainable in acidic conditions.

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Kuroda, Yuki, Akira Marui, Yoshio Arai, Atsushi Nagasawa, Shinichi Tsumaru, Ryoko Arakaki, Jun Iida et al. "Impact of dialysis in patients undergoing bioprosthetic aortic valve replacement". Interactive CardioVascular and Thoracic Surgery 33, n. 3 (7 maggio 2021): 348–53. http://dx.doi.org/10.1093/icvts/ivab106.

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Abstract OBJECTIVES To determine the incidence of bioprosthetic structural valve deterioration in dialysis patients undergoing aortic valve replacement compared to that in patients without dialysis. METHODS This single-centre retrospective observational study included 1159 patients who underwent aortic valve replacement using bioprosthetic valves for aortic stenosis and/or regurgitation at our institution between 2007 and 2017 [patients with dialysis (group D, n = 134, 12%) or without dialysis (group N, n = 1025, 88%)]. To adjust for potential differences between groups in terms of initial preoperative characteristics or selection bias, a propensity score analysis was conducted. The final sample that was used in the comparison included 258 patients, as follows: 129 patients with dialysis (group D) and 129 patients without dialysis (group N). The cumulative incidences of all-cause death, cardiac death and moderate or severe structural valve deterioration were estimated using the Kaplan–Meier method. RESULTS Operative mortality was significantly higher in group D than group N (9% vs 0%, P = 0.001). Kaplan–Meier analysis revealed that in group D, the incidence was significantly higher for all-cause death (P < 0.001, 50% vs 18% at 5 years), cardiac death (P = 0.001, 18% vs 5% at 5 years) and moderate or severe structural valve deterioration (P < 0.001, 29% vs 5% at 5 years) compared with group N. CONCLUSIONS The incidence of structural valve deterioration in dialysis patients undergoing aortic valve replacement was higher than that in patients without dialysis. Bioprosthetic valves should be carefully selected in dialysis patients undergoing aortic valve replacement.

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Wasternack, Claus. "Deciphering the oxylipin signatures of necrotrophic infection in plants. A commentary on: Differential modulation of the lipoxygenase cascade during typical and latent Pectobacterium atrosepticum infections". Annals of Botany 129, n. 3 (9 dicembre 2021): i—iii. http://dx.doi.org/10.1093/aob/mcab142.

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This article comments on: Vladimir Y. Gorshkov, Yana Y. Toporkova, Ivan D. Tsers, Elena O. Smirnova, Anna V. Ogorodnikova, Natalia E. Gogoleva, Olga I. Parfirova, Olga E. Petrova, and Yuri V. Gogolev, Differential modulation of the lipoxygenase cascade during typical and latent Pectobacterium atrosepticum infections, Annals of Botany, Volume 129, Issue 3, 16 Februray 2022, Pages 271–285 https://doi.org/10.1093/aob/mcab108

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Kumánovics, Attila, Anup Madan, Shizhen Qin, Lee Rowen, Leroy Hood e Kirsten Fischer Lindahl. "Quod erat faciendum: sequence analysis of the H2-D and H2-Q regions of 129/SvJ mice". Immunogenetics 54, n. 7 (1 ottobre 2002): 479–89. http://dx.doi.org/10.1007/s00251-002-0494-0.

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Martins, Catia, Jessica Roekenes, Saideh Salamati, Barbara A. Gower e Gary R. Hunter. "Metabolic adaptation is an illusion, only present when participants are in negative energy balance". American Journal of Clinical Nutrition 112, n. 5 (25 agosto 2020): 1212–18. http://dx.doi.org/10.1093/ajcn/nqaa220.

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ABSTRACT Background The existence of metabolic adaptation, following weight loss, remains a controversial issue. To our knowledge, no study has evaluated the role of energy balance (EB) in modulating metabolic adaptation. Objectives The aim of this study was to determine if metabolic adaptation, at the level of resting metabolic rate (RMR), is modulated by participants’ EB status. A secondary aim was to investigate if metabolic adaptation was associated with weight regain. Methods Seventy-one individuals with obesity (BMI: 34.6 ± 3.4 kg/m2; age: 45.4 ± 8.2 y; 33 men) enrolled in a 1000-kcal/d diet for 8 wk, followed by 4 wk of weight stabilization and a 9-mo weight loss maintenance program. Body weight/composition and RMR were measured at baseline, week 9 (W9), week 13 (W13), and 1 y (1Y). Metabolic adaptation was defined as a significantly different (lower or higher) measured compared with predicted RMR. Results Participants lost on average 14 kg by W9, followed by weight stabilization at W13, and regained 29% of their initial weight loss at 1Y. Metabolic adaptation was found at W9 (−92 ± 110 kcal/d, P < 0.001) and W13 (−38 ± 124 kcal/d, P = 0.011) but was not correlated with weight regain. A significant reduction in metabolic adaptation was seen between W9 and W13 (−53 ± 101 kcal/d, P < 0.001). In a subset of participants who gained weight between W9 and W13 (n = 33), no metabolic adaptation was seen at W13 (−26.8 ± 121.5 kcal/d, P = 0.214). In a subset of participants with data at all time points (n = 45), metabolic adaptation was present at W9 and W13 (−107 ± 102 kcal/d, P < 0.001 and −49 ± 128 kcal/d, P = 0.013) but not at 1Y (−7 ± 129, P = 0.701). Conclusion After weight loss, metabolic adaptation at the level of RMR is dependent on the EB status of the participants, being reduced to half after a period of weight stabilization. Moreover, metabolic adaptation does not predict weight regain at 1Y follow-up. These trials were registered at clinicaltrials.gov as NCT02944253 and NCT03287726.

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Akhter, K., SM Ahmed, Md E. Halim, MA Kader, K. Jahan, UKR Romman e MG Ahmed. "One step cyclocondensation of (thio)barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide: Part-I". Bangladesh Journal of Scientific and Industrial Research 51, n. 2 (12 giugno 2016): 129–38. http://dx.doi.org/10.3329/bjsir.v51i2.28110.

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Some new 5, 7-diaryl-1,5-dihydro (or 1, 2, 3, 5-tetrahydro)- pyrano[2, 3-d] pyrimidin-2, 4-diones (or 2-thioxo-4-ones) (3a-h) have been synthesized in one-step by cyclocondensation of barbituric acid or thiobarbituric acid (1) with arylideneacetophenones (2a-d), in glacial acetic acid in the presence of phosphorous pentoxide. The structures of the compounds 3a-h have been determined by UV, IR, 1H NMR, 13C NMR, mass spectral data and elemental analyses. The compounds 3a-h do not seem to be available in the literatureBangladesh J. Sci. Ind. Res. 51(2), 129-138, 2016

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HAMID, M., K. BASHIR, M. RIZWAN, FEA KHILGEE, M. AAMIR e K. KHAYAM. "PHENOTYPIC DETERMINATION OF INDUCIBLE CLINDAMYCIN RESISTANT AND METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS FROM CLINICAL ISOLATES OF KHYBER TEACHING HOSPITAL, PESHAWAR". Bulletin of Biological and Allied Sciences Research 2023, n. 1 (5 luglio 2023): 41. http://dx.doi.org/10.54112/bbasr.v2023i1.41.

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Methicillin Resistant Staphylococcus aureus (MRSA) is a major pathogen involved in nosocomial infections and to some extent, in community acquired infections. Among Macrolide Lincosamine Streptogramin B (MLSB) class of drugs, Clindamycin was vigorously preferred for treating staphylococcal infections in the past few decades but, some genetic factors i.e. erm and msrA genes contribute in developing Inducible Clindamycin Resistance (iCR). Sensitivity tests performed on a routine basis cannot detect inducible resistance and may result in the failure of Clindamycin to be used as an effective medication. This study aimed to detect the phenotype of MRSA and iCR S. aureus from the clinical samples of Khyber Teaching Hospital, Peshawar. A total of 204 samples were collected randomly from each gender, 130 (63.72%) samples were isolated as S. aureus, while 74 (36.27%) were other bacterial species. Double disk diffusion (D-test) was performed to detect iCR phenotype, and 80 (61.5%) isolates showed iCR, while 50 (38.4%) were negative in this regard. MRSA phenotype was determined by strains conferring resistance to Cefoxitin antibiotic, which resulted in 84 (64.6%) isolates of MRSA and 46 (35.3%) of Methicillin Sensitive Staphylococcus aureus (MSSA). Antibiogram analysis showed efficient antimicrobial activity by Tigecycline 129 (99.2%), Fusidic Acid 126 (96.9%), and Doxycycline 124 (95.3%), while the highest resistance pattern was recorded against Ciprofloxacin 31(23.8%) and Clindamycin 28(21.5%). Our study concludes that misuse of antibiotics should be avoided to inhibit the spread of MRSA, and implementation of D-test regularly in hospitals is crucial.

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Keizman, D., P. Huang, M. A. Carducci, S. R. Denmeade e M. A. Eisenberger. "Safety and efficacy of ketoconazole (K) in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC): Contemporary experience and prognostic indicators." Journal of Clinical Oncology 29, n. 7_suppl (1 marzo 2011): 145. http://dx.doi.org/10.1200/jco.2011.29.7_suppl.145.

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145 Background: Intracrine conversion of adrenal androgens to testosterone play an important role in CRPC progression. Treatments (tx) that block adrenal steroid synthesis have shown significant clinical benefits in mCRPC. Aims: To evaluate contemporary data on safety and efficacy associated with K in mCRPC. Methods: All/unselected mCRPC pts progressing on GnRH-a and antiandrogens (AA) treated with K were retrospectively analyzed. Pts were maintained on gonadal suppression, discontinued AA, and received and K 200-400 mg t.i.d. until disease progression or dose-limiting toxicity (DLT). Initial 600mg/d dose was escalated to 1,200mg/d if a PSA decrease was not seen at 3 months (mos) or if a response/subsequent progression to 600/mg/d was observed (optional). Follow up included hematological/chemical profile q 3 mos, scans upon clinical (physical exam/symptoms) or at biochemical progression (PSA increase ≥ 25% and ≥2ng/mL from nadir). A multivariate cox regression model was used to identify variables significantly associated with disease progression. Results: From 1999-2010 (mean follow up 40 mos, range 5-129), 114 m-CRPR pts were treated with K 200mg (n=82, 72%) or 400mg (n=32, 28%) tid. Most common grade 3/4 tox events (n=23) were fatigue, abdominal discomfort, nausea, and dizziness. 9 pts (8%) had DLT (fatigue n=7, hepatotoxicity/thrombocytopenia n=1). 55/114 (48%) had ≥ 50% PSA decline. Overall median time to progression (TTP) was 8 mos (range 1-129). 14 pts remain progression free > 7 mos (range 7-129). Significant prognostic factors (table) were response to prior AA (≥6 vs <6 mos), pre-tx PSADT (≥3 vs <3 mos) and extent of disease (limited-axial skeleton and/or nodal vs extensive- appendicular skeleton and/or visceral). Conclusions: K is effective and safe in m-CRPC. Prior response to AA, PSADT ≥ 3mos and limited metastatic disease is associated with TTP and further supports a therapeutic role for suppressing adrenal androgens in m-CRPC. [Table: see text] No significant financial relationships to disclose.

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Rios Rodriguez, V., M. Torgutalp, M. D’urso, H. Haibel, F. Proft, M. Protopopov, J. Rademacher, J. Sieper e D. Poddubnyy. "AB0878 Higher vitamin D serum level is associated with a better clinical response to bDMARDs in patients with axial spondyloarthritis." Annals of the Rheumatic Diseases 81, Suppl 1 (23 maggio 2022): 1561. http://dx.doi.org/10.1136/annrheumdis-2022-eular.5312.

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BackgroundVitamin D deficiency has been shown to be associated with higher disease activity and severity of several inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease and spondyloarthritis (SpA). It is, however, unknown if vitamin D level might affect the response to treatment with biologic disease-modifying anti-rheumatic drugs (bDMARDs) in patients with SpA.ObjectivesTo investigate the association between vitamin D serum levels and the response to a bDMARD therapy in patients with axial SpA.MethodsPatients with a radiographic axial SpA (r-axSpA), fulfilling the modified New York criteria and starting a bDMARD therapy were recruited between 2015 and 2019 in an extension of the prospective German Spondyloarthritis Inception Cohort (GESPIC-AS). All patients were required to have at inclusion high disease activity (BASDAI >=4 and/or ASDAS >=2.1) despite previous treatment with nonsteroidal anti-inflammatory drugs. Demographics, patient clinical characteristics and vitamin D serum levels were collected at baseline. Disease activity measures (BASDAI, CRP, ASDAS) were assessed at baseline and after 6 months of bDMARD treatment. Vitamin D deficiency was defined as serum level of 25-hydroxyvitamin D < 20 ng/mL. A multivariable regression analysis was performed to determine the association between vitamin D serum level at baseline and the treatment response as defined by BASDAI and ASDAS change scores at month 6 as compared to baseline.ResultsA total of 129 patients with r-axSpA were included in the study. No patient took supplements of vitamin D at baseline. Patients had an average age (mean±SD) of 36.5±10.5 years, 64.3% were males and 86.6% were HLA-B27 positive. The prevalence of vitamin D deficiency in our cohort was 54.3%. Patient characteristics and disease activity were comparable with regard to the presence of vitamin D at baseline (Table 1); with the exception of body mass index (BMI), which was higher in patients with vitamin D deficiency. In the multivariable linear regression analysis, baseline serum level of vitamin D was independently and significantly associated with higher change in BASDAI and ASDAS (Figure 1).Table 1.Baseline characteristics of patients with radiographic axial SpA (n=129) according to vitamin D levels at baseline.Patients with vitamin D deficiency (<20 ng/mL)n=70Patients with normal levels of vitamin Dn=59Age, years36.6±11.036.3±10.0Male sex46 (65.7)37 (62.7)BMI, kg/m226.0±4.5*24.0±3.8Smoking, ever41 (58.6)29 (49.2)Winter and Spring, n (%)33 (47.1)23 (39.0)Symptom duration, years11.5±11.310.3±7.1HLA-B27 positive62 (88.6)50 (84.7)Uveitis ever17 (24.3)12 (20.3)Psoriasis ever11 (15.7)7 (11.9)IBD ever, n (%)2 (2.9)7 (11.9)CRP, mg/L12.9±19.313.9±15.3BASDAI5.7±1.45.4±1.4ASDAS3.4±0.83.5±0.8BASFI4.6±2.24.4±1.9BASMI3.1±1.52.7±1.3NSAID intake, current50 (71.4)45 (76.3)DMARDs intake, ever9 (12.9)6 (10.2)TNFi naive55 (78.6)47 (79.7)Corticoids intake, current5 (7.1)2 (3.4)*p value <0.05.All numerical variables were presented as mean±SD, all categorical variables were presented as n (%).BMI, body mass index; CRP, C-reactive protein; DMARD, disease-modifying antirheumatic drug; IBD, inflammatory bowel disease; NSAID, nonsteroidal anti-inflammatory drug; TNFi, tumor necrosis factor inhibitor.Figure 1.Association between the response to bDMARDs (change in BASDAI and ASDAS after 6 months) and level of vitamin D at baseline in patients with radiographic axial SpA in the multivariable regression analysis.ConclusionHigher vitamin D levels at baseline may predict a better treatment response to bDMARDs in patients with r-axSpA. It has to be shown, however, if vitamin D supplementation might result in a better treatment response in axial SpA.Disclosure of InterestsNone declared

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