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Letteratura scientifica selezionata sul tema "Cytokine"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 6 luglio 2024

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Articoli di riviste sul tema "Cytokine"

1

Berti, E., e R. Caputo. "Cytokines, cytokine receptors and cytokine antibodies". Melanoma Research 6, SUPPLEMENT 1 (settembre 1996): S25. http://dx.doi.org/10.1097/00008390-199609001-00064.

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2

Trinchieri, Giorgio. "Cytokines and cytokine receptors". Immunological Reviews 202, n. 1 (dicembre 2004): 5–7. http://dx.doi.org/10.1111/j.0105-2896.2004.00217.x.

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3

Dayer, J. M. "Cytokines and cytokine antagonists". Fresenius' Journal of Analytical Chemistry 343, n. 1 (1992): 33–34. http://dx.doi.org/10.1007/bf00331973.

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4

van Deventer, S. J. H. "Cytokines and cytokine-based therapies". Current Opinion in Gastroenterology 14, n. 4 (luglio 1998): 317–21. http://dx.doi.org/10.1097/00001574-199807000-00008.

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5

Li, Aileen W., e Wendell A. Lim. "Engineering cytokines and cytokine circuits". Science 370, n. 6520 (26 novembre 2020): 1034–35. http://dx.doi.org/10.1126/science.abb5607.

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6

Burger, D., e J. M. Dayer. "Inhibitory cytokines and cytokine inhibitors". Neurology 45, Issue 6, Supplement 6 (1 giugno 1995): S39—S43. http://dx.doi.org/10.1212/wnl.45.6_suppl_6.s39.

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7

Ansel, John, Patricia Perry, Jeffrey Brown, David Damm, Tuan Phan, Charles Hart, Thomas Luger e Stephen Hefeneider. "Cytokine Modulation of Keratinocyte Cytokines". Journal of Investigative Dermatology 94, n. 6 (giugno 1990): s101—s107. http://dx.doi.org/10.1111/1523-1747.ep12876053.

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8

Thipphawong, John. "Inhaled cytokines and cytokine antagonists". Advanced Drug Delivery Reviews 58, n. 9-10 (ottobre 2006): 1089–105. http://dx.doi.org/10.1016/j.addr.2006.07.014.

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9

Olbei, M., D. Modos, D. Cozzetto, N. Powell e T. Korcsmaros. "P070 Global cytokine—cytokine interaction framework to uncover communication channels between elements of the immune system". Journal of Crohn's and Colitis 17, Supplement_1 (30 gennaio 2023): i236. http://dx.doi.org/10.1093/ecco-jcc/jjac190.0200.

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Abstract Background Cytokines are small peptides that signal between a variety of cell types and are one of the fundamental communication elements of the immune system. A variety of cytokine—cytokine interactions have previously been investigated in the literature, describing cytokines activating or inhibiting other cytokines in target cell types, and thus progressing the immune response to infection and illness. Disruption of cytokine communication is often an important goal in drug development as these compounds allow quelling and managing an overactive immune response in chronic diseases, such as Inflammatory Bowel Disease (IBD). In our previous work, we have introduced CytokineLink, a novel computational framework developed to establish cytokine—cytokine interactions from transcriptomics data (Olbei et al., Cells, 2021). Methods In this project, we generated a global network of cytokine—cytokine interactions based on cytokine response transcriptomics data from over 2000 datasets deposited in the CytoSig database. Using CytoSig’s significance analysis protocol, we established statistically significant cytokine—cytokine interactions, and determined the likely intracellular pathways connecting upstream and target cytokines using the OmniPath interaction resource. Results The resulting network is a signed, directed network of cytokine communication, containing 488 cytokine—cytokine interactions of 91 cytokines. The interactions in the network are annotated with the intracellular pathways that the included cytokines are anticipated to utilise, as well as the stimulatory and inhibitory effects that the cytokines have on one another. The resource captures the cytokine—cytokine networks of cytokines crucial in the pathophysiology of IBD, such as TNF, IL2, IL21, and OSM, which may grant novel insights into the cytokine pathways important in the molecular mechanisms underlying chronic diseases like IBD. The resource can be used by the community as a knowledge base for hypothesis generation, and is freely available through the NDEx platform. Conclusion In our work, we generated a novel computational framework collating how cytokines differentially regulate the expression of one another based on cytokine response transcriptomics data. The resulting interactions are signed, highlighting the inhibitory or stimulatory nature of the associations, and the change in expression associated with each link. The resource could be used to identify previously unknown network pharmacology targets, and to better understand the cytokine dysregulation in chronic diseases such as IBD by illustrating the interplay of the most influential IBD associated cytokines with other cytokines.

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Standiford, Theodore. "Anti-inflammatory Cytokines and Cytokine Antagonists". Current Pharmaceutical Design 6, n. 6 (1 aprile 2000): 633–49. http://dx.doi.org/10.2174/1381612003400533.

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Tesi sul tema "Cytokine"

1

Webb, Ginette Rachel. "Cytokines and cytokine receptors in osteoarthritis". Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388158.

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Deller, Marc Christian. "Structural studies of cytokines and cytokine receptors". Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.326028.

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Palmblad, Karin. "Cytokines and cytokine-directed intervention in experimental arthritis /". Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4589-6/.

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Affò, Silvia. "Cytokines and Cytokine-Receptors in the Pathogenesis of Alcoholic Hepatitis". Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/145435.

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By performing a translational study we identified a specific pattern of genes differentially regulated in patients with severe alcoholic hepatitis (AH). A functional analysis of the gene expression profile showed several pathways deregulated in AH, including cytokines- cytokine receptor interaction. Within cytokine-cytokine receptor interaction pathway, Fn14 has been identified as the only receptor belonging to TNF superfamily to be exclusively up-regulated in patients with AH, and its expression has been shown to be associated with severity of the disease and mortality. We observed that Fn14 is upregulated in experimental models of progenitor cell expansion and co-expressed with Ep-CAM in livers of patients with AH, suggesting that Fn14 may regulate ductular reaction expansion. Moreover, we showed that Fn14 hepatic expression is regulated by ethanol and pro-fibrogenic factors, suggesting that alcohol abuse together with fibrogenic mediators may be directly responsible for the induction of Fn14 expression in ALD. Furthermore, transcriptome analysis identified CCL20 as the most up-regulated cytokine in the liver of patients with AH. Hepatic expression and serum levels of CCL20 have been found elevated in patients with AH and have been showed to be associated with key clinical features of the disease such as fibrosis, endotoxemia and short-term mortality. These data suggest that besides playing a role in AH pathogenesis, CCL20 may also be considered as a potential non-invasive biomarker. We found that CCL20 hepatic expression is up-regulated in acute, chronic and acute-on chronic experimental model of liver injury induced by carbon tetrachloride (CCl4) and lipopolysaccharide (LPS) and their combination, respectively. Macrophages and hepatic stellate cells have been identified as the main CCL20 producing cell types in experimental models of acute-on-chronic liver injury. Moreover, we have showed that CCL20 exerts pro-fibrogenic and pro-inflammatory and effects on primary human hepatic stellate cells and on macrophages, suggesting that CCL20 may participate in both hepatic fibrosis and inflammation during liver disease in an autocrine and paracrine manner. Finally, we have found that CCL20 mediates LPS-induced liver injury by promoting hepatocellular apoptosis, expression of pro-inflammatory and pro-fibrogenic mediators and by enhancing macrophages and neutrophils infiltrate recruitment. In conclusion, during this thesis we performed two studies leading to the identification of new potential targets for therapy in AH. The identification of Fn14 and CCL20 as new potential targets for therapy in AH and their correlations with key hallmarks of the disease such as ethanol consumption, fibrosis, progenitor cells expansion and endotoxemia underline the complexity of this disease and the crosstalk between many mediators that occurs in AH. The data presented in this thesis suggest that cytokines and cytokine-receptor pathway could represent a new potential target for therapy in ALD; and also provide new important insights and a useful resource for the study of the pathogenesis of this disease.
El consumo de alcohol es una de las causas más importantes de mortalidad que pueden prevenirse en nuestro país. La hepatitis alcohólica (HA) se caracteriza por un proceso de inflamación hepática (fundamentalmente por infiltración de células polimorfonucleares), esteatosis masiva hepática, fibrosis pericelular y daño hepatocelular. En la actualidad no existen tratamientos efectivos para el tratamiento de la HA y por esta razón, existe una clara necesidad de identificar nuevas dianas terapéuticas para tratar a estos pacientes en los diferentes estadios de la enfermedad (esteatosis, inflamación y/o fibrogénesis). El objetivo principal de esta tesis fue investigar nuevas dianas terapéuticas para el tratamiento de la HA. Para alcanzar dicho objetivo, realizamos estudios traslacionales que permitieran identificar marcadores biológicos alterados en muestras humanas procedentes de hígados de pacientes con HA para estudiar la función que tienen en el desarrollo de la enfermedad in vitro e in vivo en modelos animales de diferentes tipos de daño hepático y valorar si podrían considerarse como dianas terapéuticas. Mediante la performación de nuestros estudios, identificamos a la vía de citoquinas-receptores de citoquinas como una de las vías con el mayor número de genes diferentemente regulados en pacientes con HA con respecto a controles sanos. Estudios en muestras humanas y en modelos animales de daño hepático nos permitieron identificar al receptor de citoquinas Fn14 y a la citoquina CCL20 como importantes mediadores de la HA, correlacionados tanto con aspectos clínicos característicos así como con la gravedad de la enfermedad. La vía de citoquinas y receptores de citoquinas y, de manera específica Fn14 y CCL20 han sido identificados como novedosos mediadores implicados en la patogénesis de la HA y por lo tanto como potenciales dianas terapéuticas. Por lo tanto, gracias a la identificación de un patrón de los genes diferentemente regulados en la HA, nuestros datos proporcionan importantes resultados novedosos para el estudio de la patogénesis de la HA.

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Ozaki, Akihiko. "Expression of cytokines and cytokine receptors in human Schwann cells". Kyoto University, 2008. http://hdl.handle.net/2433/135921.

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Croxford, J. Ludovic. "Gene therapy for experimental allergic encephalomyelitis by delivery of inhibitory cytokines or cytokine inhibitors". Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314201.

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Dossinger, Veronika. "Kleeblattpeptide und proinflammatorische Cytokine". [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965165604.

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Turner, Martin John Charles. "Regulation of cytokine production". Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46588.

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Ventevogel, Melissa Samo. "Cytokine Modulation of Thymopoiesis". NCSU, 2008. http://www.lib.ncsu.edu/theses/available/etd-03182008-100350/.

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The thymus is an organ derived from embryonic endoderm and mesoderm differentiation. It is located above the heart and is made up of two compartments, the thymic epithelial space and the perivascular space. The thymic epithelial space consists of the cortex and the medulla, which is where T cell development, maturation and induction of self tolerance occur in a process known as thymopoiesis. The thymus is susceptible to chronic and acute stressors that result in thymic involution. A consequence of thymic involution is reduced thymopoiesis, which affects the generation of a diverse T cell repertoire and establishment of central T cell tolerance. Many thymosuppressive and thymostimulatory cytokines are involved in thymopoiesis and thymic involution. Keratinocyte growth factor and IL-7 are two cytokines that function in driving early thymic progenitor proliferation and T cell development, respectively. We hypothesized that IL-7 and Keratinocyte growth factor, delivered via recombinant adenovirus, can improve thymopoiesis and T cell reconstitution in mice in an endotoxin model of acute thymic atrophy. Analysis of thymus weight, cellularity, phenotype and TCR gene rearrangement showed moderate increases in thymic function with delivery of IL-7 or Keratinocyte growth factor versus control. Taken together, these data suggested that IL-7 and Keratinocyte growth factor, delivered via recombinant adenoviruses, have thymostimulatory effects on the thymus in normal thymus or settings of acute thymic atrophy and maybe beneficial for future development as therapeutics.

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Jordan, William James. "Cytokine responses during alloreactivity". Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406452.

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Libri sul tema "Cytokine"

1

Cytokines and cytokine receptors. 2^a ed. Oxford: IRL, 1993.

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2

Callard, R. E. The cytokine factsbook. London: Academic Press, 1994.

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3

Constantin, Bona, e Revillard Jean-Pierre, a cura di. Cytokines and cytokine receptors: Physiology and pathological disorders. Amsterdam: Harwood Academic, 2000.

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4

Ibelgaufts, Horst. Dictionary of cytokines. Weinheim: VCH, 1995.

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5

Meager, Anthony. Cytokines. Englewood Cliffs, N.J: Prentice Hall, 1991.

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6

Meager, Anthony. Cytokines. Milton Keynes [England]: Open University Press, 1990.

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7

de, Ley Marc, a cura di. Cytokine protocols. Totowa, N.J: Humana Press, 2004.

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8

Fantuzzi, Giamila. Cytokine Knockouts. New Jersey: Humana Press, 2003. http://dx.doi.org/10.1385/1592594050.

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De Ley, Marc. Cytokine Protocols. New Jersey: Humana Press, 2003. http://dx.doi.org/10.1385/1592596673.

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Yoshimoto, Takayuki, e Tomohiro Yoshimoto, a cura di. Cytokine Frontiers. Tokyo: Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54442-5.

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Capitoli di libri sul tema "Cytokine"

1

Berti, E., A. Cerri, D. Tomasini e R. Caputo. "Cytokines, Cytokine Receptors and Cytokine Antibodies: Clinical Implications". In Skin Cancer and UV Radiation, 238–48. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60771-4_28.

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Behrens, Edward M. "Cytokines in Cytokine Storm Syndrome". In Cytokine Storm Syndrome, 197–207. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-22094-5_12.

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Schwab, Manfred. "Cytokine". In Encyclopedia of Cancer, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-27841-9_1473-2.

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Gooch, Jan W. "Cytokine". In Encyclopedic Dictionary of Polymers, 885. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_13506.

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Brooks, Andrew J., Farhad Dehkhoda e Birthe B. Kragelund. "Cytokine Receptors". In Endocrinology, 157–85. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-44675-2_8.

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Izuhara, Kenji, Satoshi Nunomura, Shoichiro Ohta, Masahiro Ogawa e Yasuhiro Nanri. "Cytokine Network". In Evolution of Atopic Dermatitis in the 21st Century, 97–112. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-5541-6_9.

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Minatoguchi, Shinya. "Cytokine Therapy". In Cardioprotection Against Acute Myocardial Infarction, 37–46. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-15-0167-8_6.

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Brooks, Andrew J., Farhad Dehkhoda e Birthe B. Kragelund. "Cytokine Receptors". In Endocrinology, 1–29. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-27318-1_8-1.

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Brooks, Andrew J., Farhad Dehkhoda e Birthe B. Kragelund. "Cytokine Receptors". In Endocrinology, 1–29. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-27318-1_8-2.

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Nelles, Megan, Vincenzo Salerno, Yixin Xu e Christopher J. Paige. "Cytokine Immunotherapy". In Experimental and Applied Immunotherapy, 281–305. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-980-2_13.

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Atti di convegni sul tema "Cytokine"

1

Kimmel, Jeremy D., Morgan V. DiLeo, Isabella E. Valenti, Gregory A. Gibson, Simon C. Watkins e William J. Federspiel. "Dynamics of Cytokine Capture Within Hemoadsorption Beads Used to Treat Sepsis". In ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-204764.

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Sepsis is a serious medical condition characterized by systemic inflammation caused by infection, and affects more than 750,000 individuals per year in the US, with a mortality rate of approximately 30% [1]. The pathophysiology of sepsis is complex and not entirely understood, but is believed to be related to the dysfunction of multiple interdependent humoral mediator pathways, including redundant release of inflammatory cytokines [2]. Removal of both pro- and anti-inflammatory cytokines from the circulating blood is believed to be a promising therapy for severe sepsis [3]. We are developing an extracorporeal hemoadsorption device to remove cytokines from the blood using a novel, biocompatible, sorbent bead technology. A simple model was developed to characterize cytokine adsorption within hemoadsorption beads [4]. Despite rapid clearance of cytokines with hemoadsorption in an ex vivo murine sepsis model [5], our model analysis predicted that only the outer 20μm of each sorbent bead (avg diam = 450μm) adsorbed cytokine. In this work, we used in vitro column capture experiments and confocal laser scanning microscopy (CLSM) to examine cytokine adsorption dynamics within hemoadsorption beads.

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Jurišić, Vladimir. "POSSIBILITIES OF CYTOKINE DETERMINATION AND THEIR ANALYSIS IN VARIOUS TISSUES". In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac,, 2021. http://dx.doi.org/10.46793/iccbi21.089j.

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Cytokines are small proteins that participate in many interactions between cells of the immune system as well as between many tissue cells including tumors. Currently, there is no universal classification of cytokines and they can be analyzed based on the cells that produce them or based on the type of activity. Cytokines have been studied for many years in medicine firstly in cancer patients in serum, but also in many other diseases including inflammation or other autoimmune diseases or other pathological conditions. Cytokines are still being discovered, and for many of them the structure, biological action and genes responsible for their regulation have already been determined. Bearing in mind that the development of technology has been developing enormously in the last period and those new methods of cytokine determination in various fluids and micro-concentrations are available to us. Here, the aim is to focus on the specific possibilities of determination and analysis of cytokine values in different tissues including cell culture supernatants, in individual cells as well as their genetic regulation. However, to understand their complex action in biological systems, including the pleiotropic effect of cytokines showing some time the overlap in the actions various models of analysis and interpretation of the obtained data are recommended today. This is especially complex and problematic in recent times of understanding the cytokine gene regulation and especially the possibility of their prediction. To resolve these problems, numerous databases have been created on the previously available experimental data, although their connection is not yet very clear. In addition, using integration of data, it is expected predict some models and systems in a specific situation, although it is still very difficult. So, aims are predict values in definitive situation and compare with some standards. Therefore, new methods of interpretation and new programs for analysis have been created. We expect that based on the new possibilities of analysis, better results will be achieved and that the role of these mediators for individual or personalized diagnosis or therapy in biomedicine will be determined.

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Kruglyakova, M. V., O. V. Smirnova e N. M. Titova. "CHARACTERISTICS OF THE CYTOKINE PROFILE IN PHYSIOLOGICAL AND COMPLICATED PREGNANCY". In Культура, наука, образование: проблемы и перспективы. Нижневартовский государственный университет, 2021. http://dx.doi.org/10.36906/ksp-2021/79.

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One of the priority tasks of any state is to protect the health of mothers and children. Despite the great advances in diagnostics and methods for preventing the occurrence of pathologies during pregnancy, the percentage of normal births is decreasing every year. One of the most serious complications of pregnancy is preeclampsia, the prevalence of which in the world is increasing every year. This article presents data on the cytokine profile in preeclampsia. The properties and role of the main cytokines in physiological and complicated (preeclampsia) pregnancy, relative to the control group, are described. Using the methods of enzyme immunoassay and statistical analysis, we have shown the ratio of anti-inflammatory to pro-inflammatory cytokines in health and disease. The results of the study are presented as a median (25 quartile – 75 quartile).

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Pereira, Clayrton de Barros, Yuri Felix Pedra e Renata Dellalibera-Joviliano. "Profile of IL-1 beta, INF-gamma, IL-4 and IL-17 in patients with COVID-19". In III SEVEN INTERNATIONAL MULTIDISCIPLINARY CONGRESS. Seven Congress, 2023. http://dx.doi.org/10.56238/seveniiimulti2023-175.

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The immune response to SARS-CoV-2 is mediated by several soluble chemotactic factors, including cytokines whose levels vary at different stages and types of infections. Clinical evidence shows that "cytokine storm," in which the body has high levels of several pro-inflammatory cytokines, is common in several patients with severe COVID-19. Thus, the aim of this study was to evaluate the inflammatory response mediated by the cytokines IL-1 Beta, INF-Gama, IL-4 and IL-17 in patients with COVID. Sandwich-type immunoenzymatic assays (ELISA sandwich) were performed to determine the serum cytokine concentration of a group of 11 patients with RT-PCR confirmed diagnoses compared to a control group (n=11). The samples were evaluated in duplicate and the statistical analyses of the results considered the measures of central tendency with the mean (Md). Thus, we found the results related to the different cytokines: IL-beta (patient = 138 pg/mL; control = 50 pg/mL); Interferon-gamma (patient= 104.25 pg/mL; control= 55 pg/mL); IL-4 (patient= 92.25 pg/mL; control 44 pg/mL); IL-17 (patient= 94.5 pg/mL; control 57 pg/mL). Understanding the variation in the levels of these mediators during pathology, through the analysis of the partial results of the project, is essential to elucidate the profile of the inflammatory response of patients with COVID-19.

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Kuzmina, L. P., A. G. Khotuleva e M. M. Kolyaskina. "GENETIC POLYMORPHISM OF CYTOKINES FOR OCCUPATIONAL BRONCHO OBSTRUCTIVE DISEASES DEVELOPMENT RISK AND PROGNOSIS ASSESSMENT". In The 17th «OCCUPATION and HEALTH» Russian National Congress with International Participation (OHRNC-2023). FSBSI «IRIOH», 2023. http://dx.doi.org/10.31089/978-5-6042929-1-4-2023-1-265-268.

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One of the significant systems in the pathogenesis of lung diseases is the system of cytokines. Genetic polymorphism of cytokines can be associated with different levels of cytokine production when exposed to a stimulus of the same intensity in response to antigenic irritation, or tissue damage, which can determine individual sensitivity to chemicals. The purpose of this study was to evaluate the presence of associations of single nucleotide polymorphisms of cytokine genes with the development and severity of occupational bronchoobstructive diseases, taking into account the specifics of occupational factors. Materials and methods. Examined groups: COPD from exposure to welding aerosol (n=32), asthma from exposure to high-molecular allergens of organic origin (n=31), from exposure to low-molecular chemical allergens (n=37), from exposure to metal-allergens (n=68), group comparison — without lung diseases (n=200). Genotyping of polymorphisms TNF-α G308A, IL‑6 С174G, IL‑4 С589Т, IL‑10 G1082A was carried out. Results. The association of single nucleotide polymorphisms of the TNF-α gene with the development of occupational asthma from exposure to low-molecular chemical allergens (OR=2.043; 95% CI 1.050‑3.975), the association of IL‑10 gene with the development of COPD from exposure to welding aerosol (OR=2.653; 95% CI 1.211‑5.815) was determined, the IL‑6 gene — with the severity of asthma from exposure to low-molecular chemical allergens, the IL‑4 gene — with the severity of asthma from exposure to metal allergens. Conclusion. The differential informative value of the detection of single nucleotide polymorphisms of cytokine genes as risk markers for the development and severe course of bronchoobstructive diseases, depending on the specifics of occupational factors, was determined.

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6

"From poverty to depression to inflammation: a literature review". In International Conference on Public Health and Humanitarian Action. International Federation of Medical Students' Associations - Jordan, 2022. http://dx.doi.org/10.56950/ovii9740.

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Background: Depression is the most commonly presented psychiatric disorder1 . People with low socioeconomic status are more likely to experience depression compared to those with higher socioeconomic status2 . Recent studies have revealed that people experiencing depression symptoms have a greater vulnerability to infections3 . Also, it has been shown in recent studies that there is a correlation between irregular cytokine levels and an uncontrolled inflammatory response4 . Objective: The present review addresses the relationship between the immune system response and depression. In addition to the relationship between depression and low socioeconomic status. Method: We searched PubMed for relevant studies describing the relationship between inflammatory response, depression, and low-income. Our literature survey was limited to peer-reviewed articles, written in English and published from 1990 until August 2022. Results: Different studies confirmed that psychological stress causes an alteration in the level of cytokines in multiple mechanisms4,5. Hypothalamus-pituitary-adrenal axis (HPA) is a significant immunoregulatory pathway that is activated in a variety of stress circumstances, including psychological stress6,7. Chronic psychological stress results in glucocorticoid resistance due to overactivity of the HPA axis. As a result, the inflammatory response is not appropriately managed4 . (Table1) explains the changes in the level of cytokines8 . Contrastingly, antidepressant treatment may restore normal cytokine production and decrease the risk of abnormal inflammatory response9 . Conclusion: More attention should be given to the low-middle income population and their limited access to psychiatric services as they have a higher chance of experiencing mental health disorders. Depression, which is one of the most common mental health illnesses, increases the incidence of infectious diseases. Moreover, it affects the inflammatory response. Due to the shortage of clinical trials on this subject, we recommend doing more studies to identify these clinical aspects.

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7

Wang, Wei, Hamada A. Aboubakr, James Vang, Victor Brenk, Sagar M. Goyal e James Collins. "Nanomagnetic Biosensor for the Detection of Porcine Interferon Gamma". In 2017 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2017. http://dx.doi.org/10.1115/dmd2017-3375.

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Due to the anatomical and physiological similarities to humans that include similar heart size, flow rate, skin, liver enzymes and bone healing, porcine models as a powerful investigational platform have been widely used in research areas such as diabetes, obesity and islet transplantation [1]. The advantages of relative low cost, ease in handling and comparatively short period of breeding time may make swine provide a promising solution to the shortage of human donors and difficulty in isolating purified islets from adult human in future. Porcine cytokines play a significant role in innate immunity, apoptosis, angiogenesis, cell growth and differentiation. They are involved in cellular responses, maintenance of homeostasis, and disease states such as inflammatory disease, cardiovascular disease, and cancer. Thus, the technologies to analyze the expression of cytokines are developed rapidly and are still hot topics. The traditional approach for cytokine detection and quantification is the use of an enzyme-linked immunosorbent assay (ELISA). However, its inability to do multiplex test calls for more robust detection system. Biochip-based assay for the detection of biological agents using giant magnetoresistive (GMR) sensors and magnetic nanoparticles have emerged recently [2, 3]. It is proved that the nanomagnetic biosensor technology has advantages of low cost, high sensitivity, multiplexity, and real-time signal readout. The integration of GMR biosensor and use of weak magnetic fields allow to eventually realize point-of-care and portability. In addition, interferon gamma (IFNγ) is one of the most important porcine cytokines, and is associated with a number of autoinflammatory and autoimmune diseases. In this work, IFNγ is selected as a model target for the detection of porcine cytokine using nanomagnetic GMR biosensor.

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8

Liu, Xiaotong. "Anti-cytokine strategies targeting CAR-T cell therapy-induced cytokine release syndrome". In Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), a cura di Alan Wang. SPIE, 2024. http://dx.doi.org/10.1117/12.3012927.

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9

Rajan, Neena, Nathaniel Stetson, Passquale Razzano, Mitchell Levine, Daniel Grande e Nadeen Chahine. "Response of Mesenchymal Stem Cells and Intervertebral Disc Cells to Inflammatory Challenge". In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53937.

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Human intervertebral disc (IVD) degeneration is accompanied by elevated levels of pro-inflammatory cytokines, particularly IL-1β and TNF-α [1–3]. Cytokine secretion by disc cells increases catabolic breakdown of the tissue, resulting in a positive feedback of disc integrity loss and further inflammation [4–6]. A recent study by our group has shown that severity of degeneration in an injury model can influence the therapeutic effect of cell based repair, such as treatment with mesenchymal stem cells (MSCs) [7]. The goal of this study is to measure the response of MSCs to inflammatory challenge, and to compare this response to that of differentiated disc cells from the nucleus pulposus (NP), annulus fibrosis (AF) and end plate (EP). In this study, we investigated the effects of lipopolysaccharide (LPS) on intervertebral disc cells and MSCs viability, pro-inflammatory cytokine expression and extracellular matrix (ECM) expression. LPS is an endotoxin that induces strong immune responses in animal tissue and hence widely used as a pre-clinical model of inflammation. This approach provides an opportunity to study broad aspects of the physiological inflammatory process observed in degenerative disc disease.

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Quintela, Bárbara M., Thaís S. Marins, Steven A. Garan, Elliott K. Suen, Kian Talaei, Nuno R. B. Martins, Julia R. Jahansooz e Walter Piszker. "A Differential Equation Based Model of Cell and Cytokine Activation Influenced by Glucose Dynamics and Elevated Cortisol Levels Due to Aging". In Simpósio Brasileiro de Computação Aplicada à Saúde. Sociedade Brasileira de Computação - SBC, 2023. http://dx.doi.org/10.5753/sbcas.2023.229512.

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Immunosenescence refers to the alterations in the immune system that occur due to the aging process, which increases susceptibility to diseases and reduces vaccine efficacy. Consequently, understanding the impact of aging on the immune system is crucial for simulating the different ways in which it can be challenged, thereby increasing life expectancy and quality of life. This study combines two mathematical models to understand how cortisol affects and is affected by the glucose uptake and the proand anti-inflammatory cytokines under infection. Cortisol concentration follows a diurnal rhythm and increases with glucose intake. The model simulates the influence of cortisol on the immune response, specifically through cytokine regulation.

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Rapporti di organizzazioni sul tema "Cytokine"

1

Weiner, Louis M. Antibody - Pretargeted Cytokine Therapy of Cancer. Fort Belvoir, VA: Defense Technical Information Center, maggio 2001. http://dx.doi.org/10.21236/ada395111.

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2

Weiner, Louis M. Antibody - Pretargeted Cytokine Therapy of Cancer. Fort Belvoir, VA: Defense Technical Information Center, maggio 2002. http://dx.doi.org/10.21236/ada407653.

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3

Egilmez, Nejat K. Tumor Vaccination With Cytokine-Loaded Microspheres. Fort Belvoir, VA: Defense Technical Information Center, dicembre 2005. http://dx.doi.org/10.21236/ada457688.

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4

Weiner, Louis M. Antibody - Pretargeted Cytokine Therapy of Cancer. Fort Belvoir, VA: Defense Technical Information Center, giugno 2003. http://dx.doi.org/10.21236/ada418149.

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5

Weiner, Louis. Antibody - Pretargeted Cytokine Therapy of Cancer. Fort Belvoir, VA: Defense Technical Information Center, maggio 2000. http://dx.doi.org/10.21236/ada382515.

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6

Zeng, Yulin, Liwei Wang, Hai Zhou e Yu Qi. Th1/Th2 cytokine profiles differentiating tuberculous from malignant pleural effusions: A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, gennaio 2022. http://dx.doi.org/10.37766/inplasy2022.1.0005.

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Review question / Objective: To clarify which one has a different predominance of Th1 and Th2 immune responses in malignant and tuberculous pleural effusions. We did a meta-analysis of the results published previously to assess the levels of Th1/Th2 cytokines in two types of pleural effusion and evaluated its ability to distinguish TPE from MPE. Condition being studied: Malignant and tuberculous pleural effusions are the two most common types of exudative pleural effusions, both of which can be seen with the typical accumulation of lymphocytes. Immune responses mediated by either the Th1 or Th2 subset dominate, depending on different types of pleural effusion. Thus, we performed a meta-analysis of all available studies to quantitatively evaluate the levels of Th1/Th2 cytokine profiles in TPE and MPE, as well as to assess the potential diagnostic value of these cytokines in discriminating TPE from MPE.

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Reichard, Sherwood. Journal of Leukocyte Biology. The Cytokine Odyssey 2001. Fort Belvoir, VA: Defense Technical Information Center, novembre 2001. http://dx.doi.org/10.21236/ada399076.

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8

Passer, Brent J. Systemic Oncolytic Cytokine HSV Therapy of Prostate Cancer. Fort Belvoir, VA: Defense Technical Information Center, maggio 2008. http://dx.doi.org/10.21236/ada492787.

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9

Krueger, James M. Mechanisms of Cytokine Induction in Acute Viral Infections. Fort Belvoir, VA: Defense Technical Information Center, settembre 2002. http://dx.doi.org/10.21236/ada411626.

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10

Carvey, Paul M. Cytokine Induction of Dopamine Neurons from Progenitor Cells. Fort Belvoir, VA: Defense Technical Information Center, ottobre 2000. http://dx.doi.org/10.21236/ada391417.

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