Bibliografie tematiche / Cyclocurcumin / Articoli di riviste

Articoli di riviste sul tema "Cyclocurcumin"

Segui questo link per vedere altri tipi di pubblicazioni sul tema: Cyclocurcumin.
Autore: Grafiati
Pubblicato: 8 giugno 2024

Cita una fonte nei formati APA, MLA, Chicago, Harvard e in molti altri stili

Scegli il tipo di fonte:

Vedi i top-28 articoli di riviste per l'attività di ricerca sul tema "Cyclocurcumin".

Accanto a ogni fonte nell'elenco di riferimenti c'è un pulsante "Aggiungi alla bibliografia". Premilo e genereremo automaticamente la citazione bibliografica dell'opera scelta nello stile citazionale di cui hai bisogno: APA, MLA, Harvard, Chicago, Vancouver ecc.

Puoi anche scaricare il testo completo della pubblicazione scientifica nel formato .pdf e leggere online l'abstract (il sommario) dell'opera se è presente nei metadati.

Vedi gli articoli di riviste di molte aree scientifiche e compila una bibliografia corretta.

1

Losantos, Raúl, Jérémy Pecourneau, Maxime Mourer, Stéphane Parant, Andreea Pasc e Antonio Monari. "trans–cis Photoisomerization of a biomimetic cyclocurcumin analogue rationalized by molecular modelling". Physical Chemistry Chemical Physics 23, n. 22 (2021): 12842–49. http://dx.doi.org/10.1039/d1cp01224j.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
Abstract (sommario):
The photoisomerization process of a biomimetic cyclocurcumin derivative is explored by molecular modelling. It presents enhanced capabilities respect to natural cyclocurcumin in terms of isomerization, TPA and environment dependency.
2

Gasbarri, Carla, e Guido Angelini. "Cyclocurcumin as Promising Bioactive Natural Compound: An Overview". Molecules 29, n. 7 (24 marzo 2024): 1451. http://dx.doi.org/10.3390/molecules29071451.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
Abstract (sommario):
Although identical in molecular formula and weight, curcumin and cyclocurcumin show remarkable differences in their reactivity. Both are natural compounds isolated from the rhizome of turmeric, the former is involved in the diketo/keto-enol tautomerism through the bis-α,β-unsaturated diketone unit according to the polarity of the solvent, while the latter could react by trans-cis isomerization due to the presence of the α,β-unsaturated dihydropyranone moiety. Even if curcumin is generally considered responsible of the therapeutical properties of Curcuma longa L. due to its high content, cyclocurcumin has attracted great interest over the last several decades for its individual behavior and specific features as a bioactive compound. Cyclocurcumin has a hydrophobic nature characterized by fluorescence emission, solvatochromism, and the tendency to form spherical fluorescent aggregates in aqueous solution. Molecular docking analysis reveals the potentiality of cyclocurcumin as antioxidant, enzyme inhibitor, and antiviral agent. Promising biological activities are observed especially in the treatment of degenerative and cardiovascular diseases. Despite the versatility emerging from the data reported herein, the use of cyclocurcumin seems to remain limited in clinical applications mainly because of its low solubility and bioavailability.
3

Kesharwani, Rajesh K., Simran Kumari, Dev Bukhsh Singh e Sandeep Tripathi. "A Docking Simulation Study of Some Herbal Molecules Against Influenza A Virus by Targeting Neuraminidase". Current Traditional Medicine 6, n. 2 (27 febbraio 2020): 147–54. http://dx.doi.org/10.2174/2215083805666190808092031.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
Abstract (sommario):
Background: Human Swine flu is a viral disease caused by Influenza A virus, an orthomyxovirus, contains the glycoprotein neuraminidase described as H1N2. Neuraminidase, a glycoside hydrolase enzyme assist in budding from the host cells. The medicines available for the treatment of swine flu are Oseltamivir and Zanamivir acting against glycoproteins, mainly haemagglutinin and neuraminidase. Ayurvedic medicinal system described many herbs which acts as antiviral and among that Curcumin, Bisdemethoxycurcumin, Cyclocurcumin, Ascorbic Acid and Eugenol have been selected based on their potential antiviral properties. Objective: This study aims to provide the interaction between Curcumin, Bisdemethoxycurcumin, Cyclocurcumin, Ascorbic Acid and Eugenol (herbal molecules) against influenza A virus by targeting Neuraminidase. Methods: The selected protein target (1NN2.pdb) of swine flu (neuraminidase) was downloaded from Protein Data Bank with resolution 2.2 A0. The ligands (Curcumin, Cyclocurcumin, Bisdemethoxycurcumin, Ascorbic acid, Eugenol and Zanamvir) for the docking study have been download form PubChem database. The present study has been performed using docking simulation with the help of AutoDock Vina. Results: Result shows that the Curcumin, Bisdemethoxycurcumin and Cyclocurcumin is showing good binding affinity with target protein, Nuraminidase as compared to known drug Zanamivir and other selected ligands (Eugenol, Ascorbic Acid). The docking energy values varies between -4.9 to -7.5 Kcal/mole. Conclusion: The present study has shown that the Curcumin, Bisdemethoxycurcumin and Cyclocurcumin showing good binding affinity with target protein, Nuraminidase as compared to known binder Zanamivir and other selected ligands (Eugenol, Ascorbic Acid). Curcumin and their derivatives (Bisdemethoxycurcumin, Cyclocurcumin) based drugs may act singly or synergistically along with other known drugs and prove to be more effective for influenza type A treatment.
4

Adhikary, Ramkrishna, Charles A. Barnes, Rachel L. Trampel, Samuel J. Wallace, Tak W. Kee e Jacob W. Petrich. "Photoinducedtrans-to-cisIsomerization of Cyclocurcumin". Journal of Physical Chemistry B 115, n. 36 (15 settembre 2011): 10707–14. http://dx.doi.org/10.1021/jp200080s.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
5

Li, Yunkui, Marirosa Toscano, Gloria Mazzone e Nino Russo. "Antioxidant properties and free radical scavenging mechanisms of cyclocurcumin". New Journal of Chemistry 42, n. 15 (2018): 12698–705. http://dx.doi.org/10.1039/c8nj01819g.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
6

Kim, Keunyoung, Jung-Jun Kim, Yeryeon Jung, Ji-Yoon Noh, Ahmed Shah Syed, Chul Young Kim, Moo-Yeol Lee, Kyung-Min Lim, Ok-Nam Bae e Jin-Ho Chung. "Cyclocurcumin, an Antivasoconstrictive Constituent ofCurcuma longa(Turmeric)". Journal of Natural Products 80, n. 1 (9 gennaio 2017): 196–200. http://dx.doi.org/10.1021/acs.jnatprod.6b00331.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
7

Marazzi, Marco, Antonio Francés-Monerris, Maxime Mourer, Andreea Pasc e Antonio Monari. "Trans-to-cis photoisomerization of cyclocurcumin in different environments rationalized by computational photochemistry". Physical Chemistry Chemical Physics 22, n. 8 (2020): 4749–57. http://dx.doi.org/10.1039/c9cp06565b.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
Abstract (sommario):
Solvent effects determine the fate of cyclocurcumin photochemistry: in non-polar environments fluorescence is preferred, while in polar solvents the photoisomerization path is opened, paving the way to applications as chemosensors and for theranostic purposes.
8

Ngo, Thien, Keunyoung Kim, Yiying Bian, Gwang-Jin An, Ok-Nam Bae, Kyung-Min Lim e Jin-Ho Chung. "Cyclocurcumin from Curcuma longa selectively inhibits shear stress-induced platelet aggregation". Journal of Functional Foods 61 (ottobre 2019): 103462. http://dx.doi.org/10.1016/j.jff.2019.103462.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
9

Pecourneau, Jérémy, Raúl Losantos, Antonio Monari, Stéphane Parant, Andreea Pasc e Maxime Mourer. "Synthesis and Photoswitching Properties of Bioinspired Dissymmetric γ-Pyrone, an Analogue of Cyclocurcumin". Journal of Organic Chemistry 86, n. 12 (8 giugno 2021): 8112–26. http://dx.doi.org/10.1021/acs.joc.1c00598.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
10

Losantos, Raúl, Giacomo Prampolini e Antonio Monari. "A Portrait of the Chromophore as a Young System—Quantum-Derived Force Field Unraveling Solvent Reorganization upon Optical Excitation of Cyclocurcumin Derivatives". Molecules 29, n. 8 (12 aprile 2024): 1752. http://dx.doi.org/10.3390/molecules29081752.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
Abstract (sommario):
The study of fast non-equilibrium solvent relaxation in organic chromophores is still challenging for molecular modeling and simulation approaches, and is often overlooked, even in the case of non-adiabatic dynamics simulations. Yet, especially in the case of photoswitches, the interaction with the environment can strongly modulate the photophysical outcomes. To unravel such a delicate interplay, in the present contribution we resorted to a mixed quantum–classical approach, based on quantum mechanically derived force fields. The main task is to rationalize the solvent reorganization pathways in chromophores derived from cyclocurcumin, which are suitable for light-activated chemotherapy to destabilize cellular lipid membranes. The accurate and reliable decryption delivered by the quantum-derived force fields points to important differences in the solvent’s reorganization, in terms of both structure and time scale evolution.
11

Angelini, Guido, Axel Gansmüller, Jérémy Pécourneau e Carla Gasbarri. "An insight into cyclocurcumin cis–trans isomerization: Kinetics in solution and in the presence of silver nanoparticles". Journal of Molecular Liquids 333 (luglio 2021): 116000. http://dx.doi.org/10.1016/j.molliq.2021.116000.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
12

Opustilová, Kristýna, Barbora Lapčíková, Lubomír Lapčík, Shweta Gautam, Tomáš Valenta e Peng Li. "Physico-Chemical Study of Curcumin and Its Application in O/W/O Multiple Emulsion". Foods 12, n. 7 (25 marzo 2023): 1394. http://dx.doi.org/10.3390/foods12071394.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
Abstract (sommario):
Curcuma is a world-renowned herb known for its immense health benefits. In this study, physicochemical analyses were performed on the curcumin standard sample and curcumin multiple emulsions. The emulsions were analysed for thermal and structural stability for 21 days. Confocal laser microscopy (CLSM) was performed in order to observe the emulsion encapsulation. Modulated differential scanning calorimetry (MDSC) and HPLC methods revealed a variety of curcuminoids (curcumin, demethoxycurcumin, bisdemethoxycurcumin, and cyclocurcumin) in the investigated curcumin standard. In addition, the MDSC method was found to be suitable and comparable to HPLC for determining the curcuminoid substances. The analysis of the curcumin release revealed a value of 0.18 w.% after 14 days as the equilibrium value. Furthermore, an increase in the sizes of the emulsions was observed at the end of the 21-day study. The emulsion stability index (ESI) was used to measure the stability of multiple emulsions. The ESI reached 55.8% between 7 and 21 days later. Nano droplets of the oil phase loaded with dispersed curcumin particles captured inside the water-based carboxymethylcellulose micelles were clearly observed by CLSM.
13

Hidayah, Rizka Nurul, Belia Bima Nafisa, Miftah Saiful 'Arifin, Dewi Santosaningsih e Roihatul Muti'ah. "Antiviral Activitiy of Curcumin, Demethoxycurcumin, Bisdemethoxycurcumin and Cyclocurcumin compounds of Curcuma longa against NSP3 on SARS-CoV-2". Indonesian Journal of Cancer Chemoprevention 13, n. 3 (14 febbraio 2023): 166. http://dx.doi.org/10.14499/indonesianjcanchemoprev13iss3pp166-174.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
Abstract (sommario):
SARS-CoV-2 genome encodes two large polyproteins (pp), pp1a and pp1ab which are cleaved and transformed into a mature form by a protease, non-structural protein 3 (NSP3). NSP3 is encoded by open reading frame (ORF) 1a/b. Curcuma longa (C. longa) or turmeric has been documented to have antiviral effects. The aim of this study was to assess the viral activities of C. longa against SARS-CoV-2 focusing on its potency to inhibit viral replication by targeting NSP3. PubChem databases were used to obtain the metabolic profile of C. longa. The compound's interaction with nucleocapsid was analyzed using molecular docking with Molegro Virtual Docker. Bioinformatics analysis based on rerank score presents all compounds of C. longa have higher binding affinity than the native ligand with cyclocurcumin as the lowest score (-128.38 kcal/mol). This anti-viral activity was hypothesized from the similarity of hydrogen bonds with amino acid residues Ser 128 and Asn 40 as key residues present in Ribavirin. This study reveals that C. longa is the potential to be developed as an antiviral agent through replication inhibition in SARS-CoV-2 targeting its replication mediated by NSP3.Keywords: C. longa, Non-Structural Protein 3, COVID-19.
14

Nguyen, Thi Thu Ha, Thi Tu Anh Le, Thanh Tra Nguyen e The Son Ninh. "Curcuminoids from the Vietnamese Curcuma longa: Phytochemical analysis and biological activities". Ministry of Science and Technology, Vietnam 64, n. 3 (15 settembre 2022): 19–23. http://dx.doi.org/10.31276/vjste.64(3).19-23.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
Abstract (sommario):
A phytochemical investigation on the ethanolic (EtOH) extract of the Vietnamese Curcuma longa (C. longa) rhizomes has led to the isolation of four curcuminoids including curcumin (1), demethoxycurcumin (2), bisdemethoxycurcumin (3), and cyclocurcumin (4). The chemical structure of compounds 1-4 was elucidated by Nuclear magnetic resonance (NMR) and Mass spectrometry (MS) spectral data. Based on High-performance liquid chromatography (HPLC) quantitative analysis, the amounts of three major compounds 1-3 in the C. longa extract were calculated and reached 7.215±0.101, 3.927±0.031, and 2.255±0.049 mg/g, respectively. Curcuminoids 1-4 have induced IC50 values of 9.23-14.6 μg/ml in a 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay as compared with that of the positive control resveratrol (IC50 11.5 μg/ml). Compounds 1-4 with IC50 values ranging between 8.7-15.54 μg/ml were better than the positive control acarbose (IC50 169.14 μg/ml) in α-glucosidase inhibitory examination. In addition, the EtOH extract and compounds 1-4 were also responsible for inhibitions against enzyme acetylcholinesterase and four cancer cell lines including including epidermoid carcinoma (KB), hepatocellular carcinoma (HepG2), lung cancer (SK-LU-1), and breast cancer (MCF7).
15

Nair, Akhila, Augustine Amalraj, Joby Jacob, Ajaikumar B. Kunnumakkara e Sreeraj Gopi. "Non-Curcuminoids from Turmeric and Their Potential in Cancer Therapy and Anticancer Drug Delivery Formulations". Biomolecules 9, n. 1 (2 gennaio 2019): 13. http://dx.doi.org/10.3390/biom9010013.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
Abstract (sommario):
Over the past decades curcuminoids have been extensively studied for their biological activities such as antiulcer, antifibrotic, antiviral, antibacterial, antiprotozoal, antimutagenic, antifertility, antidiabetic, anticoagulant, antivenom, antioxidant, antihypotensive, antihypocholesteremic, and anticancer activities. With the perception of limited toxicity and cost, these compounds forms an integral part of cancer research and is well established as a potential anticancer agent. However, only few studies have focused on the other bioactive molecules of turmeric, known as non-curcuminoids, which are also equally potent as curcuminoids. This review aims to explore the comprehensive potency including the identification, physicochemical properties, and anticancer mechanism inclusive of molecular docking studies of non-curcuminoids such as turmerones, elemene, furanodiene (FN), bisacurone, germacrone, calebin A (CA), curdione, and cyclocurcumin. An insight into the clinical studies of these curcumin-free compounds are also discussed which provides ample evidence that favors the therapeutic potential of these compounds. Like curcuminoids, limited solubility and bioavailability are the most fragile domain, which circumscribe further applications of these compounds. Thus, this review credits the encapsulation of non-curcuminoid components in diverse drug delivery systems such as co-crystals, solid lipid nanoparticles, liposomes, microspheres, polar-non-polar sandwich (PNS) technology, which help abolish their shortcomings and flaunt their ostentatious benefits as anticancer activities.
16

Hotsumi, Mayumi, Misato Tajiri, Koki Makabe e Hiroyuki Konno. "Design, synthesis and evaluation of diaryl γ-dihydropyrone derivatives as cyclocurcumin mimetics and inhibitors of the aggregation of amyloid β". Bioorganic Chemistry 104 (novembre 2020): 104302. http://dx.doi.org/10.1016/j.bioorg.2020.104302.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
17

Alves, Daniela Ribeiro, Matheus Nunes da Rocha, Camila Caldas Oliveira Passos, Márcia Machado Marinho, Emmanuel Silva Marinho e Selene Maia de Morais. "Curcumins and its derivatives as potential inhibitors of New Coronavirus (COVID-19) main protease: an in silico strategy". Research, Society and Development 11, n. 1 (2 gennaio 2022): e6511124334. http://dx.doi.org/10.33448/rsd-v11i1.24334.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
Abstract (sommario):
Coronavirus (COVID-19) disease outbreak caused a worldwide pandemic with a powerful lethal potential and still, there is no specific treatment to it. Natural bioactive molecules like curcumins were investigated in this work aiming to block the active site of COVID-19 Main protease (Mpro), since they present several biological activities, being more suitable in terms of fewer side effects, once this disease overloads the immune system of patients. Hereby, curcumin and several derivatives were screened for their ability to react with Mpro receptors (PDB: 6LU7). N3, Azithromycin (AZT), and Baracitinib (BRT) were evaluated as positive controls and in combined therapeutics possibilities with curcumins. N3, AZT, and BRT bound to different protein receptors, and also it was observed that N3 bound in the same site as hexahydrocurcumin and curcumin glucuronide bound at the AZT’s site and bisdemethoxycurcumin, curcumin, curcumin sulfate, cyclocurcumin, demethoxycurcumin, dihydrocurcumin and hexahydrocurcuminol bound at BRT’s site. All molecules analyzed have high force interaction fields. Once the viral activity is mainly intracellular, these compounds also were evaluated for their hydropathic abilities. All molecules were classified and considered capable of membrane cell invading. These results suggest that the therapeutic approach of the curcumin derivatives associated with AZT and the antiviral inhibitor N3 is promissory for future evaluation of their synergism in in vitro and in vivo tests to define their additional viability in the treatment of COVID-19.
18

Indradi, Raden Bayu, Dian Ayu Eka Pitaloka e Suryani Suryani. "Network pharmacology to uncover potential anti-inflammatory and immunomodulatory constituents in Curcuma longa rhizome as complementary treatment in COVID-19". Pharmacia 69, n. 4 (14 novembre 2022): 995–1003. http://dx.doi.org/10.3897/pharmacia.69.e89799.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
Abstract (sommario):
The immune status of patients plays an essential role in COVID-19. Herbal medicine with immunomodulatory and anti-inflammatory effect could have potential as a complementary therapeutic along with modern medicine. This study aims to investigate the anti-inflammatory and immunomodulatory constituents of Curcuma longa (C. longa) and its possible mechanisms in COVID-19. We systematically sorted the biochemical of C. longa rhizome from literature and repository. Next, we investigated targets related to COVID-19 in the selected active phytochemical constituents and analyzed the possible mechanisms against COVID-19 and performed molecular docking with four essential target proteins in COVID-19 for further verification. Ten active phytochemical constituents of C. longa were predicted to interact with four protein targets. The epidermal growth factor was the most interacted protein targeted by Calebin A, curcumin, cyclocurcumin, demethoxycurcumin, turmeronol a, turmeronol b, caffeic acid, and quercetin. Interferon-gamma was performed as the most critical protein targeted by 4-hydroxycinnamic acid. Curcumin was also predicted to interact with toll-like receptor 4 and Ar-turmerone with angiotensin II receptor type 2. We also reported four signaling pathways associated with target proteins-active phytochemical constituents against COVID-19: cytokine-cytokine receptor interaction, toll-like receptor signaling pathway, Jak-STAT signaling pathway, and PI3K-Akt signaling pathway. In conclusion, multi compounds in C. longa might act synergistically against COVID-19 by affecting the inflammatory and immune responses, and other pathological processes through multiple targets and pathways.
19

Fu, Min, Lihui Chen, Limin Zhang, Xiao Yu e Qingrui Yang. "Cyclocurcumin, a curcumin derivative, exhibits immune-modulating ability and is a potential compound for the treatment of rheumatoid arthritis as predicted by the MM-PBSA method". International Journal of Molecular Medicine 39, n. 5 (20 marzo 2017): 1164–72. http://dx.doi.org/10.3892/ijmm.2017.2926.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
20

Pundir, Hemlata, Ramanand Pathak, Tanuja Pant, Manish Pant, Subhash Chandra e Sushma Tamta. "In Silico Screening of Phytochemicals Targeting SmdCD of Streptococcus mutans using Molecular Docking Approach". Trends in Sciences 20, n. 6 (17 marzo 2023): 6036. http://dx.doi.org/10.48048/tis.2023.6036.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
Abstract (sommario):
Introduction: Dental caries is a chronic infectious disease caused by bacteria forming a biofilm formation on the tooth surface. Drug-resistant bacteria Streptococcus mutans (S. mutans) pose a vital public health issue. To overcome this, the development of effective drugs with a novel mechanism of action is very important. Drug repurposing is considered a viable alternative approach to overcome the above issue. In the present study, we have attempted to select unique and traditional source used as in traditional medicine. To continue this effort, in this study we used phytochemical of selected to find an effective cure for dental caries. Materials and methods: Inhibition of S. mutans deoxycytidylate deaminases (SmdCDs) is a promising drug development strategy against S. mutans, responsible for biofilm formation. Since no effective drugs are available against S. mutans, we conducted a virtual screening of phytochemicals to find novel compounds against this bacterium. Hence, we created a library of 871 phytochemicals from 13 plants with reported antimicrobial activity. The phytochemical library was subjected to virtual screening against the SmdCD target. Results and discussion: Traditionally, many cultures use chewing sticks for oral hygiene maintenance. In the present work, out of 871 phytochemicals, 211 phytochemicals showed the most druggable substance with zero violation from any of the drug-likeness rules. Further, the binding energy indicates the affinity of adhesion of protein structure docked with 2 hit potential herbal compounds of which Cyclocurcumin and Androsta-1,4,6-triene-3,17-dione showed the best docking with SmdCD. Conclusions: Based on the binding energy score, we suggest that hit compounds can be used for dental caries and further could be developed as an organic mouthwash. HIGHLIGHTS Streptococcus mutans is common in the human oral cavity and contributes significantly to tooth decay mutans deoxycytidylate deaminases (SmdCDs) are responsible for biofilm formation causing drug resistance SmdCDs can be used to develop effective drug against mutans, responsible for biofilm formation Screening phytochemicals may result potential compounds which can be used to develop new drugs against mutans GRAPHICAL ABSTRACT
21

Delova, Anastasiia, Raul Losantos, Jérémy Pecourneau, Maxime Mourer, Andreea Pasc e Antonio Monari. "Modelling the effects of E/Z photoisomerization of a cyclocurcumin analogue on the properties of cellular lipid membranes". Physical Chemistry Chemical Physics, 2023. http://dx.doi.org/10.1039/d3cp02955g.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
Abstract (sommario):
We study a cyclocurcumin analogue interacting with lipid membranes. The formation of stable membrane aggregates is confirmed as well as the perturbation induced by E/Z isomerization, thus making it a good candidate for light-induced chemotherapy.
22

Rajagopal, Kalirajan, Potlapati Varakumar, Aparma Baliwada e Gowramma Byran. "Activity of phytochemical constituents of Curcuma longa (turmeric) and Andrographis paniculata against coronavirus (COVID-19): an in silico approach". Future Journal of Pharmaceutical Sciences 6, n. 1 (16 ottobre 2020). http://dx.doi.org/10.1186/s43094-020-00126-x.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
Abstract (sommario):
Abstract Background In early 2020, many scientists are rushing to discover novel drugs and vaccines against the coronavirus, and treatments for COVID-19, because coronavirus disease 2019 (COVID-19), a life-threatening viral disease, affected first in China and quickly spread throughout the world. In this article, in silico studies have been performed to explore the binding modes of chemical constituents for natural remedies like Curcuma longa (turmeric) and Andrographis paniculata against COVID-19 (PDB ID 5R82) targeting coronavirus using Schrodinger suit 2019-4. The molecular docking studies are performed by the Glide module, in silico ADMET screening was performed by the QikProp module, and binding energy of ligands was calculated using the Prime MM-GB/SA module. Results The chemical constituents from turmeric like cyclocurcumin and curcumin and from Andrographis paniculata like andrographolide and dihydroxy dimethoxy flavone are significantly binding with the active site of SARS CoV-2 main protease with Glide score more than − 6 when compared to the currently used drugs hydroxychloroquine (− 5.47) and nelfinavir (− 5.93). When compared to remdesivir (− 6.38), cyclocurcumin from turmeric is significantly more active. The docking results of the compounds exhibited similar mode of interactions with SARS CoV-2. Main protease and the residues THR24, THR25, THR26, LEU27, SER46, MET49, HIE41, GLN189, ARG188, ASP187, MET165, HIE164, PHE181, and THR54 play a crucial role in binding with ligands. Conclusion Based on in silico investigations, the chemical constituents from turmeric like cyclocurcumin and curcumin and from Andrographis paniculata like andrographolide and dihydroxy dimethoxy flavone, significantly binding with the active site of SARS CoV-2 main protease, may produce significant activity and be useful for further development.
23

MANDAL, SAJAL, e SHUBHAM WANARASE. "IN SILICO APPROACH TO IDENTIFY POTENTIAL ANTI-PSORIATIC COMPOUNDS FROM CURCUMA LONGA". Innovare Journal of Medical Sciences, 6 luglio 2023, 1–6. http://dx.doi.org/10.22159/ijms.2023.v11i4.47979.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
Abstract (sommario):
Objectives: Psoriasis is a type of skin disease which is accompanied with over production of keratinocytes, itchiness, and scaly skin. In this study, an attempt was made to recognize naturally occurring phytocompounds from the plant Curcuma longa which can be helpful in treating psoriasis using molecular docking techniques. Methods: The protein associated to the mechanism of psoriasis was obtained from the protein data bank database, along with retrieving the phytocompounds from C. longa. The phytocompounds were docked with the protein using PyRx docking. Further, analysis was done using Swiss-absorption, distribution, metabolism, and excretion (ADME), ADME toxicity (ADMET) LAB 2.0, and ProTox webservers to evaluate the credibility of the best docked compounds. Results: Molecular docking study shows that two compounds, piperine and cyclocurcumin, have the potential to inhibit the protein interferon-gamma protein (IFNY), hindering the mechanism of psoriasis. Drug likeliness and ADMET properties also suggest that these two compounds exhibit potential drug like properties. Conclusion: The present study suggests that piperine and cyclocurcumin have significant binding affinity and they could inhibit the protein IFNY and also helps to manage the therapeutic strategies against psoriasis.
24

Delova, Anastasiia, Raúl Losantos, Jérémy Pecourneau, Yann Bernhard, Maxime Mourer, Andreea Pasc e Antonio Monari. "Perturbation of Lipid Bilayers by Biomimetic Photoswitches Based on Cyclocurcumin". Journal of Chemical Information and Modeling, 8 dicembre 2022. http://dx.doi.org/10.1021/acs.jcim.2c01152.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
25

Pecourneau, Jérémy, Raúl Losantos, Axel Gansmuller, Stéphane Parant, Yann Bernhard, Maxime Mourer, Antonio Monari e Andreea Pasc. "Tuning the competition between photoisomerization and photothermy in biomimetic cyclocurcumin analogues". Journal of Photochemistry and Photobiology A: Chemistry, gennaio 2023, 114583. http://dx.doi.org/10.1016/j.jphotochem.2023.114583.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
26

Chakraborty, Sandeep, Artashes Karmenyan, Jin-Wu Tsai e Arthur Chiou. "Inhibitory effects of curcumin and cyclocurcumin in 1-methyl-4-phenylpyridinium (MPP+) induced neurotoxicity in differentiated PC12 cells". Scientific Reports 7, n. 1 (dicembre 2017). http://dx.doi.org/10.1038/s41598-017-17268-3.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
27

Pundir, Hemlata, Tanuja Pant, Ramanand Pathak, Manish Pant, Subhash Chandra e Sushma Tamta. "In silico Screening of Potential Compounds from Medicinal Plants by Targeting Streptococcus mutans Deoxycytidylate Deaminase". Journal of Pharmaceutical Research International, 15 dicembre 2022, 1–11. http://dx.doi.org/10.9734/jpri/2022/v34i567249.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri
Abstract (sommario):
Dental caries is the chronic infectious disease caused by bacteria to from a biofilm formation on the tooth surface of man. Drug-resistant Streptococcus mutans (S. mutans) poses a vital public health issue. To overcome this, the development of effective drugs with novel mechanism of action is requisite. Drug repurposing is considered a viable alternative approach to overcome the above issue. In the present study, we have attempted to selected unique and traditional source use as in traditional medicine. Traditionally, many cultures use chewing sticks for oral hygiene maintenance. When properly used, these chewing sticks are found to be efficient due to the combined effect of mechanical cleaning, enhanced salivation and the antimicrobial action of leached out plant. Inibition of the S. mutans deoxycytidylate deaminases (SmdCDs) is the most promising drug development strategy against the S. mutans, responsible for the biofilm formation. In the present work, out of 871 phytochemicals 211 phytochemicals were showed the most druggable substance with zero violation from any of druglikeness rule. Further, the binding energy indicates the affinity of the adhesion of protein structure docked with the 2 hit potential herbal compounds of which Cyclocurcumin and Androsta-1,4,6-triene-3,17-dione showed best docking with the SmdCD.
28

Gasbarri, Carla, e Guido Angelini. "Combined calorimetric, spectroscopic and microscopic investigation on the inclusion complex from cyclocurcumin and sulfobutylether-β-cyclodextrin in aqueous solution and Kinetics of thermal cis-trans isomerization". Colloids and Surfaces A: Physicochemical and Engineering Aspects, febbraio 2023, 131149. http://dx.doi.org/10.1016/j.colsurfa.2023.131149.

Testo completo
Gli stili APA, Harvard, Vancouver, ISO e altri

Vai alla bibliografia