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Articoli di riviste sul tema "Cutaneous carcinoma"

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Autore: Grafiati

Pubblicato: 8 giugno 2024

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1

Puri, Neerja, Sukhmani Kaur Brar e B. K. Brar. "A study on the cutaneous manifestations of an internal malignancy in a tertiary care center in North India". Our Dermatology Online 12, n. 2 (1 aprile 2021): 140–44. http://dx.doi.org/10.7241/ourd.20212.7.

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Introduction: Cutaneous metastases may precede a malignancy and, in other cases, herald the recurrence of a malignancy after surgery. Aim: To determine the significance of cutaneous manifestations in patients with an internal malignancy and to observe the various types of carcinomas in patients attending a dermatology OPD. Methods: This was a prospective hospital-based study undertaken to observe the cutaneous features in a dermatology OPD in patients coming from the oncology department of a medical college. Results: The commonest malignancy in males was a lung carcinoma, observed in 5.50% of the patients, followed by a prostate carcinoma, observed in 4.58% of the patients, an esophagus carcinoma, observed in 4.12% of the patients, and a penis carcinoma, observed in 2.29% of the patients. Specific cutaneous manifestations included cutaneous metastatic infiltrates, observed in 5.04% of the patients, and carcinoma erysipeloides, observed in 1.37% of the patients. Discussion: Skin metastases may herald the recurrence of a malignancy after treatment and usually indicate a poor prognosis.

2

Onak Kandemir, Nilufer, Figen Barut, Kıvanç Yılmaz, Husnu Tokgoz, Mubin Hosnuter e Sukru Oguz Ozdamar. "Renal Cell Carcinoma Presenting with Cutaneous Metastasis: A Case Report". Case Reports in Medicine 2010 (2010): 1–5. http://dx.doi.org/10.1155/2010/913734.

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Renal cell carcinoma is the most common kidney tumor in adults. Cutaneous metastasis is a rare first symptom of the disease. This paper describes the diagnosis of a renal cell carcinoma that was indicated by cutaneous metastasis in the head and neck region, and considers the etiopathogenesis of such cases. A careful skin examination is important to detect cutaneous metastasis associated with renal cell carcinomas. Metastatic skin lesions in the head and neck region must be taken into consideration during a differential diagnosis.

3

Novice, Taylor Shea, David Oberlin e Chauncey McHargue. "A case of cutaneous metastatic adenosquamous carcinoma of the cervix". SKIN The Journal of Cutaneous Medicine 3, n. 4 (8 luglio 2019): 271–74. http://dx.doi.org/10.25251/skin.3.4.7.

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Introduction:Cutaneous metastasis of cervical carcinoma is very rare, with a reported incidence of .1 to 2%. The adenosquamous carcinoma subtype has been reported the least.3-5 We present a case report of ulceronodular cutaneous metastasis of adenosquamous carcinoma of the cervix.Case Description:A 50-year-old African American female with an eleven-year history of metastatic adenosquamous carcinoma of the cervix presented to the emergency department with an asymptomatic rash in her groin for one-month duration. On physical exam, there were hyperpigmented to violaceous papulonodules across the mons pubis and three ulcerated plaques of the left mons pubis. Punch biopsy was consistent with metastases of cervical adenosquamous carcinoma. No disease specific interventions were taken, and the patient passed away five weeks later.Discussion:Cervical cancer rarely metastasizes to the skin, with a reported incidence of .1 to 2%. Among the subtypes, cutaneous metastasis of cervical adenosquamous carcinoma has been reported the least. In a review of 1185 cases of cervical cancer, Imachi et al found that only 15 cases spread cutaneously, none of which were adenosquamous carcinoma.5 Cutaneous metastases of cervical carcinoma predict a poor prognosis, with an average length of survival of three months.6Our patient developed cutaneous metastases eleven years after diagnosis, which is to our knowledge the longest reported interval from initial diagnosis to development of cutaneous metastases. Although rare, it is important to recognize cutaneous metastases of adenosquamous carcinoma of the cervix as it predicts a poor prognosis and treatment has not been shown to improve outcomes.

4

Binsheikhan, S., S. Mittal e M. Al Abadie. "Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome) in Children". European Journal of Medical and Health Sciences 3, n. 5 (30 settembre 2021): 15–17. http://dx.doi.org/10.24018/ejmed.2021.3.5.888.

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Introduction: Gorlin syndrome or nevoid basal cell carcinoma syndrome (NBCCS) is a rare genetic disorder characterised by development of multiple basal cell carcinomas (BCC) at a young age. Case report: A 7 year female child presented with MULTIPLE skin growths on the neck, face and upper chest for 3 years, with prominent forehead and mild non-scarring alopecia. She also had a history of medulloblastoma treated 3 years ago. There was no significant family history. Biopsy from one of the lesions showed basal cell carcinoma (BCC). Discussion: Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominantly inherited disorder caused by mutations in the tumour suppressor patched 1 (PTCH-1) gene. Patients present with both cutaneous and extra-cutaneous manifestations. Multiple basal cell carcinomas (BCCs) are one of the most frequent cutaneous manifestations, occurring on both photo-exposed and non-exposed areas. The commonest extra-cutaneous tumours are medulloblastomas, which are often the first presentation of the disease. There are multiple but no established treatment modalities for the disease.

5

Binsheikhan, S., S. Mittal e M. Al Abadie. "Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome) in Children". European Journal of Medical and Health Sciences 3, n. 5 (30 settembre 2021): 15–17. http://dx.doi.org/10.24018/ejmed.2021.3.5.888.

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Introduction: Gorlin syndrome or nevoid basal cell carcinoma syndrome (NBCCS) is a rare genetic disorder characterised by development of multiple basal cell carcinomas (BCC) at a young age. Case report: A 7 year female child presented with MULTIPLE skin growths on the neck, face and upper chest for 3 years, with prominent forehead and mild non-scarring alopecia. She also had a history of medulloblastoma treated 3 years ago. There was no significant family history. Biopsy from one of the lesions showed basal cell carcinoma (BCC). Discussion: Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominantly inherited disorder caused by mutations in the tumour suppressor patched 1 (PTCH-1) gene. Patients present with both cutaneous and extra-cutaneous manifestations. Multiple basal cell carcinomas (BCCs) are one of the most frequent cutaneous manifestations, occurring on both photo-exposed and non-exposed areas. The commonest extra-cutaneous tumours are medulloblastomas, which are often the first presentation of the disease. There are multiple but no established treatment modalities for the disease.

6

Moreno de Oliveira Fernandes, Tânia Rita, Ricardo Santana de Lima, Ana Kívia Silva Matias, Leonardo Pereira de Souza Alves e Marcus Vinícius Solano Ferreira de Souza. "Cutaneous Metastasis as the Presenting Sign of Urothelial Carcinoma". Journal of the Portuguese Society of Dermatology and Venereology 78, n. 3 (27 settembre 2020): 255–59. http://dx.doi.org/10.29021/spdv.78.3.1203.

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Cutaneous metastases of visceral neoplasms are rare conditions, and urothelial or transitional cell carcinomas are responsible for less than 1% of cases. We report the case of a 50-year-old male patient who progressively developed multiple cutaneous nodules on his head, abdomen, axilla, and groin, some with ulceration. Skin biopsy and immunohistochemistry were consistent with cutaneous metastasis of urothelial carcinoma. Computed tomography scan revealed generalized metastasis in internal organs. In this rare case, cutaneous metastases were the presenting sign of the disease and, as reported, a sign of bad prognosis.

7

Vandeweyer, Eric, François Sales e Rika Deraemaecker. "Cutaneous verrucous carcinoma". British Journal of Plastic Surgery 54, n. 2 (marzo 2001): 168–70. http://dx.doi.org/10.1054/bjps.2000.3440.

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8

Pleat, Jonathon, Lisa Sacks e Howard Rigby. "Cutaneous verrucous carcinoma". British Journal of Plastic Surgery 54, n. 6 (settembre 2001): 554–55. http://dx.doi.org/10.1054/bjps.2001.3639.

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9

Pazzini, Renato, Gustavo A. Pereira e Ricardo S. Macarenco. "Cutaneous Metaplastic Carcinoma". American Journal of Dermatopathology 40, n. 7 (luglio 2018): e100-e103. http://dx.doi.org/10.1097/dad.0000000000001070.

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10

Asuquo, Maurice E., Mark S. Umoh e Ekpo E. Bassey. "Cutaneous Metastatic Carcinoma". Advances in Skin & Wound Care 23, n. 2 (febbraio 2010): 77–80. http://dx.doi.org/10.1097/01.asw.0000363504.92360.5f.

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11

Mukhtiar, Ayesha, e Sarbar Napaki. "Cutaneous apocrine carcinoma". Pathology 56 (febbraio 2024): S67. http://dx.doi.org/10.1016/j.pathol.2023.12.229.

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12

Kumar, S. V., e Rohit Mula. "Papillary Thyroid Carcinoma Presenting as Fungating Cutaneous Mass". Asian Pacific Journal of Health Sciences 5, n. 4 (ottobre 2018): 113–15. http://dx.doi.org/10.21276/apjhs.2018.5.4.17.

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13

Fukuda, Risa, Usuda Shin, Asoda Seiji e Funakoshi Takeru. "A case of primary cutaneous adenoid cystic carcinoma". Journal of the Japan Organization of Clinical Dermatologists 33, n. 3 (2016): 389–93. http://dx.doi.org/10.3812/jocd.33.389.

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14

Sivaramakrishnan, S., e Jayakar Thomas. "Cutaneous horn arising from a basal cell carcinoma of forehead: a case report". International Journal of Research in Dermatology 5, n. 1 (25 gennaio 2019): 210. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20190248.

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<p class="abstract">The term cutaneous horn or “cornu cutaneum” is used to describe a well circumscribed usually conical hyperkeratotic mass arising from another cutaneous lesion. Several lesions have been reported to occur at the base of the keratin mass. Here we report a rare case of cutaneous horn arising from a basal cell carcinoma (BCC) over the forehead of a 52 year old female patient.</p><p class="abstract"> </p>

15

Sadr, AH, S. de Kerviler e N. Kang. "Cutaneous basal cell carcinoma with endobronchial metastasis". Annals of The Royal College of Surgeons of England 96, n. 7 (ottobre 2014): e20-e21. http://dx.doi.org/10.1308/003588414x13946184902244.

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Although basal cell carcinoma is a very common malignancy, metastasis from this tumour is extremely rare. For this reason, many plastic surgeons, dermatologists and physicians dealing with skin malignancies consider this as a locally invasive malignancy. We present a rare case of metastatic basal cell carcinoma manifested as a bronchial tumour. This case highlights the fact that despite basal cell carcinoma’s local invasive potential, the possibility of distant metastasis still exists and clinicians should therefore be cautious about interpreting extracutaneous symptoms. Chest physicians should always consider the possibility of this rare tumour in the lungs in patients with a history of large basal cell carcinomas in the head and neck region.

16

Requena, Luis, Antonio Aguilar, Guadalupe Renedo, Lucia Martín, Enric Piqué, M. Carmen Fariña e Pilar Escalonilla. "Tripe Palms: A Cutaneous Marker of Internal Malignancy". Journal of Dermatology 22, n. 7 (luglio 1995): 492–95. http://dx.doi.org/10.1111/j.1346-8138.1995.tb03430.x.

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AbstractTripe palms is a distinctive paraneoplastic cutaneous sign which is frequently associated with internal malignancy, specially carcinomas of the lung and stomach. We describe a patient with ovary carcinoma who showed a curious rugose thickening of the palms with accentuation of the normal dermatoglyphic ridges. The lesions were a specially prominent on the fingertips. The patient also showed classical acanthosis nigricans in the axillae and groin. The soles were spared. Histopathologic findings in palmar lesions consisted of an undulant epidermis, with hyperkeratosis, acanthosis, and papillomatosis. Excision of the ovary carcinoma was followed by complete regression of the cutaneous lesions. We review the literature about tripe palms and discuss the relationship between this striking cutaneous manifestation and internal malignancy.

17

Ninan, Jiby Soosen, Ajithakumari K. e Tony Mathew. "Primary Cutaneous Mucinous Carcinoma Presenting as an Unusually Large Lesion - A Rare Case Report". Journal of Evolution of Medical and Dental Sciences 10, n. 34 (23 agosto 2021): 2939–41. http://dx.doi.org/10.14260/jemds/2021/599.

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Primary cutaneous mucinous carcinoma (PCMC) also known as primary mucinous carcinoma of the skin (PMCS) or primary mucinous eccrine carcinoma (PMEC) is a rare malignant adnexal tumour of eccrine origin. Many visceral mucinous carcinomas especially of the breast and gastrointestinal tract can metastasize to the skin mimicking PCMC. Hence it is very important to rule out metastatic mucinous carcinomas before making a diagnosis of PCMC. Usually, PCMC presents as a slowgrowing tumour of considerably smaller size compared to our case. The large size and shorter duration are the key features of this case report. Here we report an unusually large-sized rare malignant tumour of skin appendage. Our patient was a 54-year-old lady who presented with progressive swelling of one year duration in the right frontoparietal area. Ultrasonography showed an ill-defined lesion in the subcutaneous plane with multiple cystic spaces within it. No bone involvement was noted. The excised lesion measured 13 x 7 x 2 cms and was diagnosed as primary cutaneous mucinous carcinoma on histopathological examination. The possibility of cutaneous secondaries from elsewhere was ruled out by detailed clinical and radiological investigations. The case is reported considering the unusually bigger size and shorter duration of this rare entity.

18

SungYul, Lee, Lee JiHye, Oh SangJin, Lee HanEul e Lee JongSuk. "Primary cutaneous sarcomatoid carcinoma". Indian Journal of Dermatology, Venereology, and Leprology 78, n. 5 (2012): 665. http://dx.doi.org/10.4103/0378-6323.100536.

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19

Alam, Murad, e Désirée Ratner. "Cutaneous Squamous-Cell Carcinoma". New England Journal of Medicine 344, n. 13 (29 marzo 2001): 975–83. http://dx.doi.org/10.1056/nejm200103293441306.

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20

Robson, Alistair, Alexander J. F. Lazar, Jara Ben Nagi, Andrew Hanby, Wayne Grayson, Meora Feinmesser, Scott R. Granter et al. "Primary Cutaneous Apocrine Carcinoma". American Journal of Surgical Pathology 32, n. 5 (maggio 2008): 682–90. http://dx.doi.org/10.1097/pas.0b013e3181590ba4.

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21

Gartrell, Richard, John Pauli e Mark Zonta. "Primary Cutaneous Mucoepidermoid Carcinoma". International Journal of Surgical Pathology 23, n. 2 (15 ottobre 2014): 161–64. http://dx.doi.org/10.1177/1066896914554834.

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22

Motaparthi, Kiran, Jyoti P. Kapil e Elsa F. Velazquez. "Cutaneous Squamous Cell Carcinoma". Advances In Anatomic Pathology 24, n. 4 (luglio 2017): 171–94. http://dx.doi.org/10.1097/pap.0000000000000157.

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23

López, Verónica, Miguel Rubio, Nuria Santonja e Esperanza Jordá. "Primary Cutaneous Mucoepidermoid Carcinoma". American Journal of Dermatopathology 32, n. 6 (agosto 2010): 618–20. http://dx.doi.org/10.1097/dad.0b013e3181cdad06.

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24

Garcia-Zuazaga, Jorge, e Suzanne M. Olbricht. "Cutaneous Squamous Cell Carcinoma". Advances in Dermatology 24 (novembre 2008): 33–57. http://dx.doi.org/10.1016/j.yadr.2008.09.007.

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25

Parekh, Vishwas, e John T. Seykora. "Cutaneous Squamous Cell Carcinoma". Clinics in Laboratory Medicine 37, n. 3 (settembre 2017): 503–25. http://dx.doi.org/10.1016/j.cll.2017.06.003.

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26

Seidl-Philipp, Magdalena, e Van Anh Nguyen. "Cutaneous squamous cell carcinoma". memo - Magazine of European Medical Oncology 13, n. 1 (8 gennaio 2020): 106–10. http://dx.doi.org/10.1007/s12254-019-00554-3.

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SummaryCutaneous squamous cell carcinoma (cSCC) accounts for approximately 20% of all skin cancers. Its rising incidence represents a major public health concern. The majority of cSCC are curable by surgical resection. Although less than 5% of cSCC patients develop metastases or local recurrence after complete excision, advanced cSCC is difficult to treat. Until recently, no standard therapeutic regimen for advanced cSCC exists. Traditional therapies include chemotherapy and EGFR-targeted therapy, but their clinical benefit remains modest and has been demonstrated mostly in retrospective studies. On the contrary, PD-1 inhibitors dramatically improve outcomes in many immunocompetent cSCC patients, resulting in the approval of cemiplimab as the first FDA-approved systemic drug for patients with locally advanced or metastatic cSCC who are not candidates for curative surgery or radiation. In the coming years combination therapies are an emerging treatment strategy that could improve efficacy of PD-1 inhibitors in advanced cSCC. Moreover, several prospective controlled trials have been designed to explore the potential role of PD-1 inhibitors in the adjuvant and neodjuvant setting. Given the paucity of data, the management of immunocompromised cSCC patients requires a heightened awareness in this new era of cancer therapeutics.

27

Vandeweyer, E., J. L. Dargent e R. Deraemaecker. "Lethal Cutaneous Verrucous Carcinoma". Acta Chirurgica Belgica 102, n. 2 (gennaio 2002): 134–36. http://dx.doi.org/10.1080/00015458.2002.11679282.

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28

Ruiz, Sory J., Suhair Al Salihi, Victor G. Prieto, Priyadharsini Nagarajan, Michael T. Tetzlaff, Jonathan L. Curry, Doina Ivan, Carlos A. Torres-Cabala e Phyu P. Aung. "Unusual cutaneous metastatic carcinoma". Annals of Diagnostic Pathology 43 (dicembre 2019): 151399. http://dx.doi.org/10.1016/j.anndiagpath.2019.08.003.

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29

Mendenhall, William M., Jessica M. Kirwan, Christopher G. Morris, Robert J. Amdur, John W. Werning e Nancy P. Mendenhall. "Cutaneous Merkel cell carcinoma". American Journal of Otolaryngology 33, n. 1 (gennaio 2012): 88–92. http://dx.doi.org/10.1016/j.amjoto.2011.02.003.

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30

Loh, Seung-Hee, Yu-Jin Oh, Bark-Lynn Lew e Woo-Young Sim. "Primary Cutaneous Apocrine Carcinoma". Annals of Dermatology 28, n. 5 (2016): 669. http://dx.doi.org/10.5021/ad.2016.28.5.669.

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31

Waldman, Abigail, e Chrysalyne Schmults. "Cutaneous Squamous Cell Carcinoma". Hematology/Oncology Clinics of North America 33, n. 1 (febbraio 2019): 1–12. http://dx.doi.org/10.1016/j.hoc.2018.08.001.

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32

Kamalpour, Loebat, Renata T. Brindise, Michael Nodzenski, Daniel Q. Bach, Emir Veledar e Murad Alam. "Primary Cutaneous Mucinous Carcinoma". JAMA Dermatology 150, n. 4 (1 aprile 2014): 380. http://dx.doi.org/10.1001/jamadermatol.2013.6006.

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Que, Syril Keena T., Fiona O. Zwald e Chrysalyne D. Schmults. "Cutaneous squamous cell carcinoma". Journal of the American Academy of Dermatology 78, n. 2 (febbraio 2018): 249–61. http://dx.doi.org/10.1016/j.jaad.2017.08.058.

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Que, Syril Keena T., Fiona O. Zwald e Chrysalyne D. Schmults. "Cutaneous squamous cell carcinoma". Journal of the American Academy of Dermatology 78, n. 2 (febbraio 2018): 237–47. http://dx.doi.org/10.1016/j.jaad.2017.08.059.

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35

Bander, Thomas S., Kishwer S. Nehal e Erica H. Lee. "Cutaneous Squamous Cell Carcinoma". Dermatologic Clinics 37, n. 3 (luglio 2019): 241–51. http://dx.doi.org/10.1016/j.det.2019.03.009.

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Niu, Dongfeng, Yanhua Bai, Qian Yao, Wei Hou, Lixin Zhou, Xiaozheng Huang e Chen Zhao. "Expression and Significance of AQP3 in Cutaneous Lesions". Analytical Cellular Pathology 2021 (26 ottobre 2021): 1–6. http://dx.doi.org/10.1155/2021/7866471.

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Aquaporin 3 (AQP3) is the membrane channel of water and involved in fluid homeostasis. The aim of this study was to reveal the expression and significance of AQP3 in cutaneous lesions. We analyzed AQP3 mRNA levels using RT-PCR in 311 cutaneous lesions and confirmed AQP3 expression in these lesions by immunohistochemistry. AQP3 mRNA was detected in normal epidermis, seborrheic keratosis, solar keratosis, Bowen’s disease, squamous cell carcinoma, eccrine poroma, apocrine carcinoma, and sebaceoma; however, AQP3 mRNA was absent in basal cell carcinoma, nevocellular nevus, or malignant melanoma. By immunohistochemistry, diffuse AQP3 expression was seen in all keratotic lesions including seborrheic keratosis, verruca vulgaris, molluscum contagiosum, solar keratosis, Bowen’s disease, and squamous cell carcinoma. Diffuse AQP3 expression was also present in all extramammary Paget’s disease. No AQP3 staining was obtained in basal cell carcinoma. Positive AQP3 staining was seen in sweat gland tumors including hidradenoma, eccrine poroma, and apocrine carcinoma. Among sebaceous tumors, AQP3 expressed diffusely in all sebaceous hyperplasia and sebaceous adenoma, but not in sebaceous carcinomas. Only focal AQP3 staining was seen in nevocellular nevus and no AQP3 staining in melanoma. Our findings indicate the function of AQP3 maintained in most skin tumors. AQP3 may be used for differential diagnosis in skin tumors.

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Westers-Attema, Annet, Myrurgia Abdul Hamid, Eline Haans, René van der Hulst e Nicole Kelleners-Smeets. "Multiple cutaneous squamous cell carcinoma in cutaneous sarcoidosis". Journal of Dermatology 42, n. 8 (18 maggio 2015): 845–46. http://dx.doi.org/10.1111/1346-8138.12931.

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Dantal, Jacques, Emmanuel Morelon, Lionel Rostaing, Eric Goffin, Anabelle Brocard, Isabelle Tromme, Nilufer Broeders et al. "Sirolimus for Secondary Prevention of Skin Cancer in Kidney Transplant Recipients: 5-Year Results". Journal of Clinical Oncology 36, n. 25 (1 settembre 2018): 2612–20. http://dx.doi.org/10.1200/jco.2017.76.6691.

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Purpose Transplant recipients who develop cutaneous squamous cell carcinomas are at high risk for multiple subsequent skin cancers. Sirolimus has been shown to reduce the occurrence of secondary skin cancers, but no study included a follow-up exceeding 2 years. We extended at 5 years the TUMORAPA randomized trial of sirolimus-based immunosuppressive regimen versus calcineurin inhibitor–based immunosuppression. Methods Kidney transplant recipients receiving calcineurin inhibitors who had at least one cutaneous squamous cell carcinoma were randomly assigned to receive sirolimus as a substitute for calcineurin inhibitors (n = 64) or to maintain their initial treatment (n = 56). The primary end point was survival free of squamous cell carcinoma at 5 years. Secondary end points included the occurrence of other skin cancers, renal function, patient and graft survival, and treatment tolerance. Results Survival free of cutaneous squamous cell carcinoma was significantly longer in the sirolimus group than in the calcineurin inhibitor group ( P = .007). In the sirolimus group, the number of patients with new skin cancers was significantly lower compared with the calcineurin inhibitor group: 22% versus 59% for squamous cell carcinomas ( P < .001), 34% versus 66% for other skin cancers ( P < .001), and 20% versus 37.5% for basal cell carcinomas ( P < .05). Kidney graft function, patients, and graft survival were similar in both groups. In the sirolimus group, the mean number of serious adverse effects per patient decreased from 1.16 during the first 2 years, to 0.83 between years 2 and 5. Conclusion In kidney transplant recipients with previous cutaneous squamous cell carcinomas, the antitumoral effect of conversion from calcineurin inhibitors to sirolimus was maintained at 5 years, and sirolimus tolerance was satisfactory.

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Jiang, Yannan, Runqiu Liu, Xinghui Li e Yunjiang Wang. "Ubiquitin-Conjugating Enzyme E2C Activates Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway to Promote Growth and Migration of Cutaneous Squamous Cell Carcinoma Cells". Current Topics in Nutraceutical Research 22, n. 2 (1 febbraio 2024): 544–51. http://dx.doi.org/10.37290/ctnr2641-452x.22:544-551.

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Cutaneous squamous cell carcinoma is prone to metastasis at its advanced stage. Previous studies reported that the ubiquitin-conjugating enzyme E2C is a proto-oncogene that causes cancer in various tumors. This study aimed to investigate the role of the ubiquitin-conjugating enzyme E2C in cutaneous squamous cell carcinoma. We initially analyzed the expression profile in the gene expression omnibus database. We obtained the intersection genes, established a protein-protein interaction network, and identified ubiquitin-conjugating enzyme E2C as the key gene. Furthermore, microarray data revealed that the ubiquitin-conjugating enzyme E2C expression is elevated in cutaneous squamous cell carcinoma. Ubiquitin-conjugating enzyme E2C overexpression plasmids and siRNA of ubiquitin-conjugating enzyme E2C were transfected into cutaneous squamous cell carcinoma cells to analyze the effects of ubiquitin-conjugating enzyme E2C on cutaneous squamous cell carcinoma cell proliferation, migration, and invasion. The expression of associated proteins was detected using Western blot assay to confirm the impact of the ubiquitin-conjugating enzyme E2C on the phosphatidylinositol-3-kinase/threonine kinase signaling pathway. Ubiquitin-conjugating enzyme E2C knockdown inhibited cutaneous squamous cell carcinoma cell viability, migration, and invasion, and the phosphatidylinositol-3-kinase/threonine kinase signaling pathway, while ubiquitin-conjugating enzyme E2C overexpression had opposite results. In summary, Ubiquitin-conjugating enzyme E2C is a potential therapeutic target for cutaneous squamous cell carcinoma since it encourages the proliferation and migration of cutaneous squamous cell carcinoma cells.

40

Poonia, Usha, Jagat Singh, Manisha Kumari e Sukriti Bansal. "Unusual presentation of lung carcinoma as nasal tip metastasis: A review of literature". IP Journal of Otorhinolaryngology and Allied Science 4, n. 3 (15 novembre 2021): 122–26. http://dx.doi.org/10.18231/j.ijoas.2021.024.

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Lung carcinoma is the most common type of carcinoma seen in males and 4 most common in females. Skin metastasis from lung carcinoma is frequent with an incidence of 1%-12%, with most common site being the anterior chest wall. Skin metastasis from lung carcinoma to the tip of nose is very rare with only 12 cases being reported in literature(Table 1). It can be confused with other benign and malignant conditions, such as infection, lymphoma, hemangioma, rhinophyma, sarcoidosis, tuberculosis and carcinomas, making its diagnosis difficult. Less than 20 cases of cutaneous nasal tip metastasis are reported in literature out of which 12 are from malignancies of lung. Sometimes it can appear earlier than the primary lesion and thus delays the diagnosis of primary lesion. = In this case report, we report a case of nasal tip cutaneous metastasis from squamous cell carcinoma of lung.

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Kramb, Felix, Christoph Doerfer, Andreas Meiwes, Karthik Ramakrishnan, Thomas Eigentler, Claus Garbe, Ulrike Keim e Ulrike Leiter. "Real-world Treatment Patterns and Outcomes with Systemic Therapies in Unresectable Locally Advanced and Metastatic Cutaneous Squamous Cell Carcinoma in Germany". Acta Dermato-Venereologica 102 (26 gennaio 2022): adv00637. http://dx.doi.org/10.2340/actadv.v101.751.

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Advanced cutaneous squamous cell carcinoma is a challenge to treat. Conventional systemic treatment options include chemotherapy and epidermal growth factor receptor-inhibitors. The aim of this study was to assess clinical outcomes with systemic treatments in advanced cutaneous squamous cell carcinoma. Patients receiving systemic treatment at the Tübingen Dermato-Oncology centre between 2007 and 2017 were identified (n = 59). Median age was 76 years (interquartile range (IQR) 71–80 years), 83.1% of patients were male, 72.9% had metastatic cutaneous squamous cell carcinoma, and 27.1% had unresectable locally advanced cutaneous squamous cell carcinoma. During median follow-up of 52 weeks (IQR 27–97 weeks), overall response rate was 14.3%, and disease control rate was 53.6%. Median progression-free survival was 15 weeks (IQR 8–42 weeks), and median overall survival was 52 weeks (IQR 27–97 weeks). Patients receiving chemoradiation vs chemotherapy alone showed better overall survival (hazard ratio 0.41, p = 0.014,) and progression-free survival (hazard ratio 0.42, p = 0.009); no differences were observed for metastatic cutaneous squamous cell carcinoma vs locally advanced cutaneous squamous cell carcinoma patients. Although chemotherapy and/or cetuximab showed limited outcomes in advanced cutaneous squamous cell carcinoma, such therapy may still be an option when anti-PD-1 treatment is contraindicated.

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Gurzó, Lilla Anna, Daniella Kuzmanovszki, Sarolta Kárpáti, Judit Hársing e Botond Tímár. "Cutaneous neuroendocrine carcinoma metastasis on the face". Bőrgyógyászati és Venerológiai Szemle 91, n. 4 (28 agosto 2015): 148–52. http://dx.doi.org/10.7188/bvsz.2015.91.4.4.

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Rosen, Jordan, Katherine Nolan, Noah Shaikh, Les Rosen e Martin Zaiac. "Coexisting Basal Cell Carcinoma and Squamous Cell Carcinoma in Congenital Nevus Sebaceous". SKIN The Journal of Cutaneous Medicine 2, n. 3 (30 aprile 2018): 181–85. http://dx.doi.org/10.25251/skin.2.3.6.

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Nevus sebaceous is a congenital epidermal hamartoma characterized by hyperplastic changes to the epidermis and adnexa. Nevus sebaceous is associated with an elevated risk of cutaneous neoplasms, most often benign; however, malignant neoplasms, most notably basal cell carcinoma, can also present in these patients. Although a rare occurrence, more often affecting adult patients, squamous cell carcinomas have also been reported to arise at the site of pre-existing nevus sebaceous. Herein we report a unique case of a patient with basal cell carcinoma and squamous cell carcinoma arising concurrently in the same nevus sebaceous.

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Soni, Monica, Sudesh Aggarwal, Prasoon Soni, Puja Gupta, Shaifali Dadhich e Sharadlata Saini. "Vulvar Merkel Cell Carcinoma: A Rare Entity". Journal of South Asian Federation of Obstetrics and Gynaecology 3, n. 3 (2011): 145–46. http://dx.doi.org/10.5005/jp-journals-10006-1153.

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ABSTRACT Merkel cell carcinoma is a primary small cell carcinoma of the skin that resembles oat cell carcinomas of the lung. This tumor has a predilection for head and neck region but may rarely occur as isolated vulvar tumor. It has aggressive malignant behavior and should not be missed while evaluating vulvar masses. We report a case of 45-year-old Mrs I, who presented with recurrent vulvar swelling and was diagnosed as stage III Merkel cell carcinoma of the vulva. Synonyms Primary neuroendocrine carcinoma, Trabecular carcinoma, Primary small cell carcinoma, Cutaneous apudoma.

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Hoy, Nathan, Joyce Wong, Muhammad Mahmood e Alain Brassard. "Basaloid Squamous Cell Carcinoma of the Nasal Septum Presenting as a Primary Cutaneous Lesion". Journal of Cutaneous Medicine and Surgery 16, n. 5 (settembre 2012): 375–77. http://dx.doi.org/10.1177/120347541201600520.

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Background: Basaloid squamous cell carcinoma is a rare aggressive variant of squamous cell carcinoma, with a predilection for the head and neck region. There are only two case reports in the literature documenting a nasal cavity squamous cell carcinoma presenting as a primary cutaneous lesion. Objective: We report a rare case of nasal cavity basaloid squamous cell carcinoma presenting initially as a nasal bridge mass. Two initial biopsies revealed features consistent with basal cell carcinoma and basosquamous cell carcinoma, respectively. Result: Final surgical pathology showed extensive invasive squamous cell carcinoma with basaloid differentiation arising from the nasal septal mucosa with extension to the overlying skin. The clinicopathologic features were interpreted as basaloid squamous cell carcinoma. Conclusion: We discuss the difficulties in pathologic diagnosis of this condition given its varied phenotypical expression. As well, this case emphasizes the necessity for diagnostic vigilance when assessing a primary cutaneous lesion as it may be a rare presentation of an underlying malignancy extending to the skin. Contexte: Le carcinome squameux basaloïde est une variante rare et très maligne du carcinome squameux, qui touche le plus souvent la tête et le cou. La documentation médicale ne compte que deux exposés de cas sur le carcinome squameux de la cavité nasale se présentant sous forme de lésion cutanée primitive. Objectif: Nous faisons état ici d'un rare cas de carcinome squameux basaloïde de la cavité nasale, se présentant au départ comme une masse dans la voûte des fosses nasales. Deux biopsies ont été pratiquées au départ, et les résultats se sont montrés compatibles avec les caractéristiques du carcinome basocellulaire et du carcinome basospinocellulaire, respectivement. Résultat: L'examen histopathologique définitif de la pièce opératoire a révélé la présence d'un carcinome squameux invasif, étendu, accompagnée d'une différenciation basaloïde prenant naissance dans la muqueuse de la cloison nasale et se prolongeant jusqu'à la peau sus-jacente. Les manifestations clinicopathologiques laissaient croire à un carcinome squameux basaloïde. Conclusion: Il sera question ici des difficultés que pose le diagnostic histopathologique de cette affection compte tenu de son expression phénotypique variée. De plus, le cas met en évidence la nécessité de faire preuve de vigilance dans l'établissement du diagnostic lorsqu'on évalue des lésions cutanées primitives étant donné que celles-ci peuvent être une manifestation rare d'une tumeur maligne sous-jacente, qui s'étend jusqu'à la peau.

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Xia, Chen, Zhigang Chu, Dongmei Jin, Yan Xiao, Wen Ma e Maojie Cheng. "Sinomenine Suppresses Cell Progression and Induces Cell Apoptosis by Regulating AKT/mTOR Signaling Pathway in Cutaneous Squamous Cell Carcinoma Cells". Current Topics in Nutraceutical Research 20, n. 2 (26 novembre 2021): 393–99. http://dx.doi.org/10.37290/ctnr2641-452x.20:393-399.

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While sinomenine plays a crucial anticancer role in a variety of cancers, its function and molecular mechanism in cutaneous squamous cell carcinoma remains unexplored. To this end, we explored the effect of sinomenine on cell viability, colony formation rate, cell apoptosis rate, and migration and invasion and wound healing in A431 and SCL-1 cells representing cutaneous squamous cell carcinoma. The results show that sinomenine inhibited cutaneous squamous cell carcinoma viability, clone formation, migration and invasion, induced cell apoptosis by inactivating AKT/mTOR pathway. These data may likely to provide a novel candidate for treating patients diagnosed with cutaneous squamous cell carcinoma.

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Xu, Yaohui G., Molly Hinshaw, B. Jack Longley, Humza Ilyas e Stephen N. Snow. "Cutaneous Adenoid Cystic Carcinoma with Perineural Invasion Treated by Mohs Micrographic Surgery—A Case Report with Literature Review". Journal of Oncology 2010 (2010): 1–5. http://dx.doi.org/10.1155/2010/469049.

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We report a 58-year-old woman with cutaneous adenoid cystic carcinoma arising on the chest treated with Mohs micrographic surgery. The patient remained tumor-free at 24-month follow-up. To date, only six other cases of cutaneous adenoid cystic carcinoma were reportedly managed by Mohs surgery. Cutaneous adenoid cystic carcinoma has low potential for distant metastasis but is notorious for its aggressive infiltrative growth pattern, frequent perineural invasion, and high risk of local recurrence after excision. We propose that Mohs surgery is an ideal method to achieve margin-free removal of cutaneous adenoid cystic carcinoma. A brief literature review is provided.

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Tele, Jyoti, S. R. Kanetkar e S. S. Kumbhar. "Solitary Cutaneous Metastasis of Carcinoma Larynx - An Unusual Occurrence". International Journal of Health Sciences and Research 12, n. 2 (16 febbraio 2022): 194–98. http://dx.doi.org/10.52403/ijhsr.20220227.

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Background - Carcinoma larynx with cutaneous metastasis is rare to occur. Cutaneous metastasis from head and neck region are usually considered a poor prognostic sign. Case Report - We report a case of moderately differentiated carcinoma of larynx presenting with solitary cutaneous metastasis in suprascapular region. Patient is a 40 year old lady, farmer by occupation who developed dysphagia and throat pain for which she was investigated and on biopsy was diagnosed as moderately differentiated squamous cell carcinoma of larynx. When she was admitted for chemoradiotherapy, a swelling was noted in right suprascapular region. FNAC of this swelling revealed metastatic Squamous Cell Carcinoma. Conclusion - Cutaneous metastases are believed to be due to systemic spread and they represent terminal stage of malignant disease with limited survival period. FNAC is a minimally invasive method, that can be used to diagnose such lesions and it is a good alternative to performing biopsies. Key words: Carcinoma Larynx, Solitary Cutaneous Metastasis, Squamous Cell Carcinoma of head and neck.

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Sundberg, J. P., M. K. O'Banion, A. Shima, C. Knupp e M. E. Reichmann. "Papillomas and Carcinomas Associated with a Papillomavirus in European Harvest Mice (Micromys minutus)". Veterinary Pathology 25, n. 5 (settembre 1988): 356–61. http://dx.doi.org/10.1177/030098588802500504.

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Papillomaviruses, group-specific papillomavirus antigens, or extrachromosomal papillomavirus DNA were detected in cutaneous, mucocutaneous, and pulmonary tumors affecting a colony of European harvest mice (Micromys minutus). Skin lesions were classified as acanthomatous hyperplasia, epidermal inclusion cysts. squamous papillomas, inverted papillomas, trichoepitheliomas, and sebaceous carcinomas. Cutaneous horns (hyperkeratotic papillomas) were on mucocutaneous junctions of one animal. One mouse, with a cutaneous sebaceous carcinoma, had multiple pulmonary keratinaceous cysts. Papillomavirus antigens, detected by the avidin-biotin technique, were in 20 of 31 lesions tested. In contrast, by Southern blot hybridization all 28 lesions tested contained papillomavirus DNA. Papillomavirus DNA was demonstrated in two often benign cutaneous lesions by in situ hybridization.

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Shahzad, Rafia, Tooba Anjum e Abu Baker Shahid. "Cutaneous metastasis in hypopharyngeal carcinoma: a case report". Asian Biomedicine 18, n. 1 (1 febbraio 2024): 30–34. http://dx.doi.org/10.2478/abm-2024-0006.

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Abstract Background Occurrence of cutaneous metastasis in hypopharyngeal carcinoma is an extremely rare event reported in the literature, with an incidence of only 0.8%–1.3%. Early diagnosis of cutaneous metastasis would have a positive impact on treatment response and disease prognosis with diagnosis mainly dependent on physical examination and radiological imaging (ultrasonography, computed tomography scan or PET-CT). Palliative care is, however, the mainstay of treatment for cutaneous metastasis. Case presentation We report a middle-aged female patient, with known case of hypopharyngeal squamous cell carcinoma, who initially showed partial response to chemoradiotherapy but developed cutaneous nodules in the region of the right axilla and bilateral lateral chest wall posterior to the posterior axillary fold. Excision biopsy of one of these nodules showed metastatic squamous cell carcinoma. The patient was again referred to the Oncology Department of INMOL Hospital and her chemotherapy was planned for cutaneous metastasis. Conclusion Being uncommon, the occurrence of cutaneous lesions in a patient with hypopharyngeal carcinoma should prompt detailed evaluation to rule out metastasis. Early detection will help in improving disease prognosis and median survival.