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Articoli di riviste sul tema "Corticosteroid sensitivity"

Autore: Grafiati

Pubblicato: 7 dicembre 2024

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1

Lewis, Brandon W., Devine Jackson, Stephanie A. Amici, et al. "Corticosteroid insensitivity persists in the absence of STAT1 signaling in severe allergic airway inflammation." American Journal of Physiology-Lung Cellular and Molecular Physiology 321, no. 6 (2021): L1194—L1205. http://dx.doi.org/10.1152/ajplung.00244.2021.

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Corticosteroid insensitivity in asthma limits the ability to effectively manage severe asthma, which is characterized by persistent airway inflammation, airway hyperresponsiveness (AHR), and airflow obstruction despite corticosteroid treatment. Recent reports indicate that corticosteroid insensitivity is associated with increased interferon-γ (IFN-γ) levels and T-helper (Th) 1 lymphocyte infiltration in severe asthma. Signal transducer and activator of transcription 1 (STAT1) activation by IFN-γ is a key signaling pathway in Th1 inflammation; however, its role in the context of severe allergic

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2

Lewis, Brandon W., Maria L. Ford, Lynette K. Rogers, and Rodney D. Britt. "Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD." Antioxidants 10, no. 9 (2021): 1335. http://dx.doi.org/10.3390/antiox10091335.

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Corticosteroid insensitivity is a key characteristic of patients with severe asthma and COPD. These individuals experience greater pulmonary oxidative stress and inflammation, which contribute to diminished lung function and frequent exacerbations despite the often and prolonged use of systemic, high dose corticosteroids. Reactive oxygen and nitrogen species (RONS) promote corticosteroid insensitivity by disrupting glucocorticoid receptor (GR) signaling, leading to the sustained activation of pro-inflammatory pathways in immune and airway structural cells. Studies in asthma and COPD models sug

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3

Tanaka, Takao, Mari Shigeta, and Masahiko Usui. "BCG inoculation and corticosteroid sensitivity." Ocular Immunology and Inflammation 9, no. 3 (2001): 207–10. http://dx.doi.org/10.1076/ocii.9.3.207.3970.

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4

Lauerma, A. I. "Screening for corticosteroid contact sensitivity." Contact Dermatitis 24, no. 2 (1991): 123–30. http://dx.doi.org/10.1111/j.1600-0536.1991.tb01664.x.

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5

Flores, Saul, Ilias Iliopoulos, Rohit S. Loomba, et al. "Glucocorticoid Receptor Polymorphisms in Children Undergoing Congenital Heart Surgery with Cardiopulmonary Bypass." Journal of Pediatric Intensive Care 09, no. 04 (2020): 241–47. http://dx.doi.org/10.1055/s-0040-1709658.

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AbstractWe conducted a candidate gene association study to test the hypothesis that different gene polymorphisms will be associated with corticosteroid responsiveness and study outcomes among children undergoing congenital heart surgery. This is a prospective observational cohort study at a large, tertiary pediatric cardiac center on children undergoing corrective or palliative congenital heart surgery. A total of 83 children were enrolled. DNA was isolated for three polymorphisms of interest namely N363 (rs56149945) and 9β (rs6198) associated with increased sensitivity to corticosteroids and

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6

Kimura, Genki, and Yasuo Kizawa. "Corticosteroid sensitivity in intractable respiratory disease." Folia Pharmacologica Japonica 145, no. 6 (2015): 329. http://dx.doi.org/10.1254/fpj.145.329.

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7

Gaucher, Louis, Leslie Adda, Alice Séjourné, et al. "Impact of the corticosteroid indication and administration route on overall survival and the tumor response after immune checkpoint inhibitor initiation." Therapeutic Advances in Medical Oncology 13 (January 2021): 175883592199665. http://dx.doi.org/10.1177/1758835921996656.

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Background: Based on their indications, systemic corticosteroids appear to negatively affect clinical outcomes in immune checkpoint inhibitor (ICI)-treated patients. There are few data on the influence of topical and inhaled corticosteroids on the ICIs’ effectiveness. Methods: In a single-center study, we retrospectively investigated the impact of systemic corticosteroids according to their indication [an immune-related adverse event (irAE) or another indication] on overall survival (OS) and the tumor response in all consecutive patients after initiation of ipilimumab, nivolumab or pembrolizum

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8

Notari, Lorella, Roxane Kirton, and Daniel S. Mills. "Psycho-Behavioural Changes in Dogs Treated with Corticosteroids: A Clinical Behaviour Perspective." Animals 12, no. 5 (2022): 592. http://dx.doi.org/10.3390/ani12050592.

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Arousal and distress are often important factors in problematic behaviours, and endogenous corticosteroids are important mediators in the associated stress responses. Exogenous corticosteroid treatments have been reported to change behaviour in human patients and laboratory animals, with similar changes also noted in pet dogs. These behaviours not only potentially adversely impact the welfare of the dogs, but also the quality of life of their owners. Indeed, corticosteroids can bias sensitivity towards aversion in dogs. A decrease in behaviours associated with positive affective states, such a

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9

Beam, William R., Robert D. Ballard, and Richard J. Martin. "Spectrum of Corticosteroid Sensitivity in Nocturnal Asthma." American Review of Respiratory Disease 145, no. 5 (1992): 1082–86. http://dx.doi.org/10.1164/ajrccm/145.5.1082.

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10

Bittar, Jan, Carlos Kamiya-Matsuoka, Pedro C. Barata, Soo-Hyun Lee-Kim, Adriana Olar, and Ivo W. Tremont-Lukats. "Corticosteroid sensitivity in gliomatosis cerebri delays diagnosis." Practical Neurology 15, no. 4 (2015): 309–11. http://dx.doi.org/10.1136/practneurol-2015-001125.

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11

Mizutani, Mirai, Julie Bérubé, Heather G. Ahlgren, et al. "Corticosteroid-resistant inflammatory signalling in Pseudomonas-infected bronchial cells." ERJ Open Research 3, no. 2 (2017): 00144–2016. http://dx.doi.org/10.1183/23120541.00144-2016.

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Decreasing the inflammatory response that leads to tissue damage during cystic fibrosis (CF) lung disease has been a long-standing goal of CF therapy. While corticosteroids are widely used anti-inflammatory drugs, their efficacy in CF lung disease remains debated. The complex interaction between the colonising bacteria and the host environment may impact corticosteroid responsiveness.In this study, sputum samples from adult CF patients were collected at baseline and during pulmonary exacerbation episodes. Lung function measurements and sputum microbiological analyses were performed. In paralle

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12

Sasaki, Eiko. "Corticosteroid sensitivity and cross-sensitivity A review of 18 cases 1967-1988." Contact Dermatitis 23, no. 5 (1990): 306–15. http://dx.doi.org/10.1111/j.1600-0536.1990.tb05164.x.

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13

Chen, Yung-Fu, Chih-Sheng Lin, Kuo-An Wang, et al. "Design of a Clinical Decision Support System for Fracture Prediction Using Imbalanced Dataset." Journal of Healthcare Engineering 2018 (2018): 1–13. http://dx.doi.org/10.1155/2018/9621640.

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More than 1 billion people suffer from chronic respiratory diseases worldwide, accounting for more than 4 million deaths annually. Inhaled corticosteroid is a popular medication for treating chronic respiratory diseases. Its side effects include decreased bone mineral density and osteoporosis. The aims of this study are to investigate the association of inhaled corticosteroids and fracture and to design a clinical support system for fracture prediction. The data of patients aged 20 years and older, who had visited healthcare centers and been prescribed with inhaled corticosteroids within 2002–

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14

Pavlovic, D., N. Viires, C. Zedda, M. Fournier, and M. Aubier. "Effects of corticosteroids on epithelial structure and smooth muscle function of rat trachea." European Respiratory Journal 11, no. 3 (1998): 575–82. http://dx.doi.org/10.1183/09031936.98.11030575.

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Corticosteroids, efficient drugs for the treatment of severe asthma, may have numerous side effects. We investigated the effects of 7 days of treatment with triamcinolone (1.2 mg x kg(-1) x day(-1)) on the epithelial structure, tracheal smooth muscle cross-sectional area and contractility in the rat. The corticosteroid-injected rats were compared to pair-fed, and pair-weighed animals. Histological studies were performed on transverse sections of glutaraldehyde-fixed tracheal blocks embedded in plastic. In the preparations taken from corticosteroid-injected, pair-fed and pair-weighed animals, p

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15

Ellington, B., J. T. McBride, and D. C. Stokes. "Effects of corticosteroids on postnatal lung and airway growth in the ferret." Journal of Applied Physiology 68, no. 5 (1990): 2029–33. http://dx.doi.org/10.1152/jappl.1990.68.5.2029.

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To investigate the influence of corticosteroids on postnatal lung and airway growth, young male ferrets were given cortisone acetate (20 mg/kg im daily) beginning at 8 wk of age. At 19 wk of age pulmonary function was measured. The lungs were excised for measurements of recoil pressures and wet and dry weights. The dimensions of central and peripheral airways were estimated from analysis of bronchial casts. Corticosteroid-treated animals were shorter and tended to be lighter than control animals but were heavier in relation to length. Total lung capacity was reduced in proportion to the reduct

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16

Raff, H., J. Shinsako, C. E. Wade, L. C. Keil, and M. F. Dallman. "Acute volume expansion decreases adrenocortical sensitivity to ACTH and angiotensin II." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 249, no. 5 (1985): R611—R616. http://dx.doi.org/10.1152/ajpregu.1985.249.5.r611.

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This study examined the plasma aldosterone and corticosteroid responses to a 60-min infusion of adrenocorticotropin (ACTH) or angiotensin (ANG) II started immediately after an acute isotonic saline volume expansion (0.5 ml . kg-1 . min-1 for 30 min). Five conscious dogs of either sex with exteriorized carotid loops were used in this repeated-design study. Volume expansion per se caused a 10% decrease in hematocrit, a 12.5% decrease in plasma protein, and a 2.7-mmHg increase in central venous pressure with no change in mean arterial pressure, heart rate, or plasma sodium. Volume expansion per s

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17

Phillips, Mark, Christopher Vannabouathong, Tahira Devji, et al. "Differentiating factors of intra-articular injectables have a meaningful impact on knee osteoarthritis outcomes: a network meta-analysis." Knee Surgery, Sports Traumatology, Arthroscopy 28, no. 9 (2020): 3031–39. http://dx.doi.org/10.1007/s00167-019-05763-1.

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Abstract Purpose There are a number of developments in intra-articular therapies that have been determined to be differentiating factors within the classes of treatments. This study evaluated the efficacy and safety of intra-articular treatments of primary knee osteoarthritis in the short term (3 months follow-up), using a network meta-analysis design, while taking within-class differentiating factors into consideration. Methods A literature search of MEDLINE (through OVID), EMBASE (through OVID), Cochrane Central Register of Controlled Trials for all trials comparing intra-articular therapies

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18

Kobayashi, Yoshiki, Kazuhiro Ito, Akira Kanda, Koich Tomoda, Nicolas Mercado, and Peter J. Barnes. "Impaired Dual-Specificity Protein Phosphatase DUSP4 Reduces Corticosteroid Sensitivity." Molecular Pharmacology 91, no. 5 (2017): 475–81. http://dx.doi.org/10.1124/mol.116.107656.

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Barry, Luke Evan, Ciaran O’Neill, and Liam G. Heaney. "Association between asthma, corticosteroids and allostatic load biomarkers: a cross-sectional study." Thorax 75, no. 10 (2020): 835–41. http://dx.doi.org/10.1136/thoraxjnl-2019-214139.

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BackgroundAllostatic load, a measure of early ageing or ‘wear and tear’ from adapting to environmental challenges, has been suggested as a framework with which to understand the stress-related disruption of multiple biological systems which may be linked to asthma. Considering the socioeconomic context is also critical given asthma and allostatic overload are more common in lower socioeconomic groups.AimsEstimate the relationship between allostatic load and its constituent biomarkers, asthma and corticosteroid prescribing while controlling for socioeconomic status.MethodsData from Understandin

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20

Packer, Claire H., Clarice G. Zhou, Alyssa R. Hersh, Allison J. Allen, Amy C. Hermesch, and Aaron B. Caughey. "Antenatal Corticosteroids for Pregnant Women at High Risk of Preterm Delivery with COVID-19 Infection: A Decision Analysis." American Journal of Perinatology 37, no. 10 (2020): 1015–21. http://dx.doi.org/10.1055/s-0040-1713145.

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Objective Antenatal corticosteroids given prior to preterm deliveries reduce the risk of adverse neonatal outcomes. However, steroid administration in the setting of a viral respiratory infection can worsen maternal outcomes. Therefore, the decision to administer corticosteroids must balance the neonatal benefits with the potential harm to the mother if she is infected with the novel coronavirus disease 2019 (COVID-19). This study aimed to determine the gestational ages for which administering antenatal corticosteroids to women at high risk of preterm labor with concurrent COVID-19 infection r

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21

Lee, Jong Wook, Jun Ho Jang, Je-Hwan Lee, et al. "Ineffective Corticosteroid Treatment for Hemolysis Management of Paroxysmal Nocturnal Hemoglobinuria." Blood 124, no. 21 (2014): 5151. http://dx.doi.org/10.1182/blood.v124.21.5151.5151.

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Abstract Background: The primary clinical manifestations of paroxysmal nocturnal hemoglobinuria (PNH) are hemolytic anemia, bone marrow failure (BMF), and thromboembolism (TE). For optimum management, the contribution of both hemolysis and BMF to the complex anemia of PNH should be determined. The treatment of a hemolytic episode should aim at diminishing hemolysis and preventing complications. Corticosteroids as treatment, for both chronic hemolysis and acute hemolytic exacerbations have been used with a variety of side effects of long term use. In the Korean PNH population, corticosteroid (7

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22

Goncalves, J., V. Macedo Silva, C. Macedo, et al. "P869 Deep ulcers in acute Ulcerative Colitis at index endoscopy predict corticosteroid resistance." Journal of Crohn's and Colitis 18, Supplement_1 (2024): i1606. http://dx.doi.org/10.1093/ecco-jcc/jjad212.0999.

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Abstract Background Ulcerative Colitis (UC) is a chronic inflammatory disease affecting the colon. Its acute form can be life-threatening, necessitating hospital admission and intravenous (IV) corticosteroid treatment. This study aimed to predict IV corticosteroid response in acute UC patients based on endoscopic findings at admission. Methods Individuals admitted to the hospital for acute UC for intravenous corticosteroid treatment were selected. Those with gastrointestinal infections and those without endoscopy at admission were excluded. Results A retrospective analysis was conducted on a c

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Larrivée, Samuel, Frédéric Balg, Guillaume Léonard, Sonia Bédard, Michel Tousignant, and Patrick Boissy. "Wrist-Based Accelerometers and Visual Analog Scales as Outcome Measures for Shoulder Activity During Daily Living in Patients With Rotator Cuff Tendinopathy: Instrument Validation Study." JMIR Rehabilitation and Assistive Technologies 6, no. 2 (2019): e14468. http://dx.doi.org/10.2196/14468.

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Background Shoulder pain secondary to rotator cuff tendinopathy affects a large proportion of patients in orthopedic surgery practices. Corticosteroid injections are a common intervention proposed for these patients. The clinical evaluation of a response to corticosteroid injections is usually based only on the patient’s self-evaluation of his function, activity, and pain by multiple questionnaires with varying metrological qualities. Objective measures of upper extremity functions are lacking, but wearable sensors are emerging as potential tools to assess upper extremity function and activity

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Mahajan, Vikram K., Vikas Sharma, Neeraj Sharma, Monika Chandel, and Rohit Verma. "Allergic contact dermatitis caused by topical corticosteroids: A review for clinicoepidemiological presentation, evaluation, and management aspects." Cosmoderma 4 (February 8, 2024): 14. http://dx.doi.org/10.25259/csdm_233_2023.

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Dermatitis medicamentosa or contact dermatitis to topically applied medicaments, active ingredients or excipients, is encountered frequently in clinical practice and should be suspected in patients showing resistance to treatment despite adequate therapy and in patients, who complain of intolerance to a particular treatment. Topical corticosteroids are prescribed mostly in dermatology for their anti-inflammatory, antiproliferative, and immunosuppressive actions to treat various inflammatory dermatoses. These may act as allergens and produce immunoglobulin E-mediated immediate hypersensitivity

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Sun, Xianwen, Qingyun Li, Yi Gong, Lei Ren, Huanying Wan, and Weiwu Deng. "Low-dose theophylline restores corticosteroid responsiveness in rats with smoke-induced airway inflammation." Canadian Journal of Physiology and Pharmacology 90, no. 7 (2012): 895–902. http://dx.doi.org/10.1139/y2012-079.

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Patients with chronic obstructive pulmonary disease (COPD) respond poorly to corticosteroids. Histone deacetylase-2 (HDAC-2) plays a pivotal role in many cases of steroid insensitivity. The main aim of this study was to restore the smoking-induced reduction in corticosteroid sensitivity by increasing HDAC-2 activity using low-dose theophylline. Rats were exposed to cigarette smoke (CS) and treated with budesonide and two doses of theophylline. Besides the pathologic examination and cell counting in the bronchoalveolar lavage fluid (BALF), the expression of HDAC-2 and CXC chemokine ligand-8 (CX

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Martinet, N., P. Vaillant, T. Charles, J. Lambert, and Y. Martinet. "Dexamethasone modulation of tumour necrosis factor-alpha (cachectin) release by activated normal human alveolar macrophages." European Respiratory Journal 5, no. 1 (1992): 67–72. http://dx.doi.org/10.1183/09031936.93.05010067.

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Recurrent infections of the lower respiratory tract are a frequent and serious side-effect of chronic corticosteroid treatment. Since alveolar macrophages (AM) are currently thought to play a central role in the protection of the lower respiratory tract against infectious agents, it is likely that a steroid-induced deficiency of AM is involved in this process. In this respect, when activated, AM are major producers of tumour necrosis factor-alpha (TNF or cachectin), a versatile cytokine with several biological properties including antiviral and anti-infectious activities. A deficit of TNF prod

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Bechmann, L., K. Busse, M. Stoppe, S. Cotte, B. Ettrich, and F. Then Bergh. "Corticosteroid receptor expression and in vivo glucocorticoid sensitivity in multiple sclerosis." Journal of Neuroimmunology 276, no. 1-2 (2014): 159–65. http://dx.doi.org/10.1016/j.jneuroim.2014.07.004.

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Azam, AA, PJ Barnes, and NM Mercado. "S66 Targeting anti-ageing molecule AMPK restores corticosteroid sensitivity in COPD." Thorax 68, Suppl 3 (2013): A36.1—A36. http://dx.doi.org/10.1136/thoraxjnl-2013-204457.73.

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Sun, Xue-Jiao, Zhan-Hua Li, Yang Zhang та ін. "Combination of erythromycin and dexamethasone improves corticosteroid sensitivity induced by CSE through inhibiting PI3K-δ/Akt pathway and increasing GR expression". American Journal of Physiology-Lung Cellular and Molecular Physiology 309, № 2 (2015): L139—L146. http://dx.doi.org/10.1152/ajplung.00292.2014.

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Corticosteroid insensitivity, which is induced by cigarette smoke extract (CSE), is a significant barrier when treating chronic obstructive pulmonary disease (COPD). Erythromycin (EM) has been shown to have an anti-inflammatory role in some chronic airway inflammatory diseases, particularly diffuse panbronchiolitis and cystic fibrosis. Here, we explored whether the combination therapy of EM and dexamethasone (Dex) reverses corticosteroid insensitivity and investigated the molecular mechanism by which this occurs. We demonstrated that the combination of EM and Dex restored corticosteroid sensit

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Darlington, D. N., K. Kaship, L. C. Keil, and M. F. Dallman. "Vascular responsiveness in adrenalectomized rats with corticosterone replacement." American Journal of Physiology-Heart and Circulatory Physiology 256, no. 5 (1989): H1274—H1281. http://dx.doi.org/10.1152/ajpheart.1989.256.5.h1274.

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To determine under resting, unstressed conditions the circulating glucocorticoid concentrations that best maintain sensitivity of the vascular smooth muscle and baroreceptor responses to vasoactive agents, rats with vascular cannulas were sham-adrenalectomized (sham) or adrenalectomized (ADRX) and provided with four levels of corticosterone replacement (approximately 100 mg fused pellets of corticosterone: cholesterol 0, 20, 40, and 80% implanted subcutaneously at the time of adrenal surgery). Changes in vascular and baroreflex responses were determined after intravenous injection of varying d

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Myers, Brent, and Beverley Greenwood-Van Meerveld. "Differential involvement of amygdala corticosteroid receptors in visceral hyperalgesia following acute or repeated stress." American Journal of Physiology-Gastrointestinal and Liver Physiology 302, no. 2 (2012): G260—G266. http://dx.doi.org/10.1152/ajpgi.00353.2011.

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Symptoms of irritable bowel syndrome (IBS) are exacerbated by stress. Previously, we demonstrated that the stress hormone corticosterone applied directly to the amygdala induced visceral hypersensitivity through the actions of glucocorticoid receptor (GR) and mineralocorticoid receptor (MR). However, the involvement of amygdaloid GR and MR in the regulation of visceral sensitivity following psychological stress is unknown; therefore, the goal of the present study was to determine the relative importance of amygdaloid GR and MR in the regulation of visceral sensitivity in a rodent model of beha

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Mohan, Anand, Mohd Adil Khan, and Suresh Chandra. "Advance approaches in alopecia." Pharmaceutical and Biological Evaluations 4, no. 3 (2017): 135. http://dx.doi.org/10.26510/2394-0859.pbe.2017.21.

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Alopecia is characterized by hair loss mainly on scalp some time on other resign of the body that has negative psychological and social impact on patients. Androgenetic alopecia and alopecia areata are common disorders. Androgenetic alopecia is the sensitivity of scalp follicles to dihydrotestosterone and alopecia areata is an autoimmune disorder. Current studies have explained the efficacy of corticosteroid therapy or the combination of ultraviolet A therapy and systemic corticosteroids for severe AA. Finasteride opens up new possibilities for the treatment of androgenetic alopecia. Current d

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Sari, Indri Widya, Rusmawardiana, and Fifa Argentina. "Ulceration of Corticosteroid-Induced StriaeDistensae in Children with Nephrotic Syndrome." Jurnal RSMH Palembang 2, no. 1 (2021): 113–18. http://dx.doi.org/10.37275/jrp.v2i1.15.

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Striaedistensae(SD) is linear scar tissue in the epidermis and dermis due to excessive stretching of the skin.Striaedistensaeoccurs due to dysfunction of extracellular matrix components that play a role in skin elasticity increasing sensitivity to minor trauma and ulceration. One of the causes is the long-term use of corticosteroids. Systemic corticosteroids are the mainstay of treatment for nephrotic syndrome, so long-term prescribing of corticosteroids should be carried out with caution. It is reported case of a 15-year-old boy with nephrotic syndrome complains of red streaks appearing on hi

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Ozawa, Hitoshi, Fang Han, and Mitsuhiro Kawata. "Exocytosis sensitivity to growth hormone-releasing hormone in subsets of GH cells in rats under different corticosterone conditions. Ultrastructural study using microwave irradiation for fixation and immunocytochemistry." Journal of Endocrinology 183, no. 3 (2004): 507–15. http://dx.doi.org/10.1677/joe.1.05656.

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Growth hormone (GH) cells in the rat anterior pituitary have been morphologically classified into three subtypes: type I (mature) containing large secretory granules about 350 nm in diameter, type II (intermediate) containing a mixture of large and small granules, and type III (immature) containing small granules about 150 nm in diameter. However, the functional implications of morphological heterogeneity, especially the different sensitivities to growth hormone-releasing hormone (GRH) under different corticosteroid conditions have not been elucidated to date. In the present study, by applicat

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Sivapalan, Pradeesh, Andras Bikov, Charlotte Suppli Ulrik, et al. "Corticosteroid Resistance in Smokers—A Substudy Analysis of the CORTICO-COP Randomised Controlled Trial." Journal of Clinical Medicine 10, no. 12 (2021): 2734. http://dx.doi.org/10.3390/jcm10122734.

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The CORTICO-COP trial showed that eosinophil-guided corticosteroid-sparing treatment for acute exacerbation of chronic obstructive pulmonary disease was non-inferior to standard of care and decreased the accumulated dose of systemic corticosteroids that patients were exposed to by approximately 60%. Smoking status has been shown to affect corticosteroid responsiveness. This post hoc analysis investigated whether eosinophil-guided treatment is non-inferior to conventional treatment in current smokers. The main analysis of current smokers showed no significant difference in the primary endpoint,

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Valenta, C., and H. Janout. "Corticosteroid Analysis by HPLC with Increased Sensitivity by Use of Precolumn Concentration." Journal of Liquid Chromatography & Related Technologies 17, no. 5 (1994): 1141–46. http://dx.doi.org/10.1080/10826079408013391.

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Lo, Chun-Yu, Charalambos Michaeloudes, Pankaj K. Bhavsar, et al. "Increased phenotypic differentiation and reduced corticosteroid sensitivity of fibrocytes in severe asthma." Journal of Allergy and Clinical Immunology 135, no. 5 (2015): 1186–95. http://dx.doi.org/10.1016/j.jaci.2014.10.031.

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Myers, Brent, and Beverley Greenwood-Van Meerveld. "Corticosteroid receptor-mediated mechanisms in the amygdala regulate anxiety and colonic sensitivity." American Journal of Physiology-Gastrointestinal and Liver Physiology 292, no. 6 (2007): G1622—G1629. http://dx.doi.org/10.1152/ajpgi.00080.2007.

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Our previous studies have shown that stereotaxic implantation of corticosterone (Cort) onto the central amygdaloid nucleus increases both anxiety and colonic sensitivity. The goal of this study was to examine the relative importance of amygdaloid glucocorticoid (GR) and mineralocorticoid receptor (MR)-mediated mechanisms in the induction of anxiety and colonic hypersensitivity. In male Fischer 344 rats, Cort or cholesterol micropellets were stereotaxically implanted bilaterally at the dorsal boundary of the central amygdaloid nucleus either alone or in combination with a GR antagonist, mifepri

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Kobayashi, Yoshiki, Akira Kanda, Dan Van Bui, et al. "Omalizumab Restores Response to Corticosteroids in Patients with Eosinophilic Chronic Rhinosinusitis and Severe Asthma." Biomedicines 9, no. 7 (2021): 787. http://dx.doi.org/10.3390/biomedicines9070787.

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Eosinophilic chronic rhinosinusitis (ECRS), which is a subgroup of chronic rhinosinusitis with nasal polyps, is characterized by eosinophilic airway inflammation extending across both the upper and lower airways. Some severe cases are refractory even after endoscopic sinus surgery, likely because of local steroid insensitivity. Although real-life studies indicate that treatment with omalizumab for severe allergic asthma improves the outcome of coexistent ECRS, the underlying mechanisms of omalizumab in eosinophilic airway inflammation have not been fully elucidated. Twenty-five patients with E

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Farhan, Mohammed A., Ahmed M. Moharram, Tareq Salah, and Omar M. Shaaban. "Types of yeasts that cause vulvovaginal candidiasis in chronic users of corticosteroids." Medical Mycology 57, no. 6 (2018): 681–87. http://dx.doi.org/10.1093/mmy/myy117.

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AbstractThe current study aims to compare between the types of yeasts that cause vulvovaginal candidiasis (VVC) in women using corticosteroid medication compared to nonusers and estimate their sensitivity to available commercial antifungal agents. In a descriptive analytical cross-sectional study, we recruited 41 chronic corticosteroid users diagnosed clinically to have VVC from Women's Health Hospital, Assiut University, Egypt. Forty-seven age-matched women with VVC were recruited as a control group. Full history and clinical examination were performed. Vaginal sterile swab obtained from the

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Bannier, Michiel A. G. E., Sophie Kienhorst, Quirijn Jöbsis, et al. "Exhaled Breath Analysis for Investigating the Use of Inhaled Corticosteroids and Corticosteroid Responsiveness in Wheezing Preschool Children." Journal of Clinical Medicine 11, no. 17 (2022): 5160. http://dx.doi.org/10.3390/jcm11175160.

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Exhaled breath analysis has great potential in diagnosing various respiratory and non-respiratory diseases. In this study, we investigated the influence of inhaled corticosteroids (ICS) on exhaled volatile organic compounds (VOCs) of wheezing preschool children. Furthermore, we assessed whether exhaled VOCs could predict a clinical steroid response in wheezing preschool children. We performed a crossover 8-week ICS trial, in which 147 children were included. Complete data were available for 89 children, of which 46 children were defined as steroid-responsive. Exhaled VOCs were measured by GC-t

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Li, Xiongjuan, Mohammed Shaqura, Doaa Mohamed, et al. "Pro- versus Antinociceptive Nongenomic Effects of Neuronal Mineralocorticoid versus Glucocorticoid Receptors during Rat Hind Paw Inflammation." Anesthesiology 128, no. 4 (2018): 796–809. http://dx.doi.org/10.1097/aln.0000000000002087.

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Abstract Background In naive rats, corticosteroids activate neuronal membrane–bound glucocorticoid and mineralocorticoid receptors in spinal cord and periphery to modulate nociceptive behavior by nongenomic mechanisms. Here we investigated inflammation-induced changes in neuronal versus glial glucocorticoid and mineralocorticoid receptors and their ligand-mediated nongenomic impact on mechanical nociception in rats. Methods In Wistar rats (n = 5 to 7/group) with Freund’s complete adjuvant hind paw inflammation, we examined glucocorticoid and mineralocorticoid receptor expression in spinal cord

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Griffiths, S. D., D. T. Goodhead, S. J. Marsden, et al. "Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis." Journal of Experimental Medicine 179, no. 6 (1994): 1789–97. http://dx.doi.org/10.1084/jem.179.6.1789.

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We have compared the sensitivity of clonogenic interleukin 7 (IL-7)-dependent murine B cell precursors with that of clonogenic mature B cells and myeloid precursors to alpha-particles from plutonium-238 and X radiation. All three populations are relatively sensitive, but B cell precursors are ultrasensitive. This differential sensitivity is also observed with corticosteroid, etoposide, and cisplatin, all apoptosis-inducing drugs used in the treatment of leukemia and other cancers. Further, we show that x-rays and drugs induce the bulk of the B cell precursor population to undergo rapid apoptos

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Kadushkin, A. G., A. D. Taganovich, A. A. Arabey, L. M. Shishlo, A. P. Lyubetskaya, and L. V. Aleshkevich. "Sensitivity to glucocorticosteroids and heterogeneity of in vitro cell response in patients with chronic obstructive pulmonary disease." Russian Pulmonology 28, no. 5 (2018): 558–66. http://dx.doi.org/10.18093/0869-0189-2018-28-5-558-566.

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Inhaled corticosteroids are widely used for the treatment of chronic obstructive pulmonary disease (COPD), but their efficacy significantly varies between patients. The aim of the study was to establish approaches to reveal steroid-sensitive and steroid-resistant patients with COPD using the blood and lung cells. Methods. Forty five patients with COPD undergoing bronchoscopy were recruited for the study of cytokine secretion by alveolar macrophages under the influence of glucocorticoids. Alveolar macrophages isolated from bronchoalveolar lavage fluid were cultured with lipopolysaccharide (LPS)

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DeRijk, R. H. "Changes in corticosteroid sensitivity of peripheral blood lymphocytes after strenuous exercise in humans." Journal of Clinical Endocrinology & Metabolism 81, no. 1 (1996): 228–35. http://dx.doi.org/10.1210/jc.81.1.228.

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Runyon, Bruce A. "Exquisite Sensitivity to Small Decrements in Corticosteroid Dose in Autoimmune Chronic Active Hepatitis." Journal of Clinical Gastroenterology 9, no. 5 (1987): 541–42. http://dx.doi.org/10.1097/00004836-198710000-00010.

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DeRijk, R. H., J. Petrides, P. Deuster, P. W. Gold, and E. M. Sternberg. "Changes in corticosteroid sensitivity of peripheral blood lymphocytes after strenuous exercise in humans." Journal of Clinical Endocrinology & Metabolism 81, no. 1 (1996): 228–35. http://dx.doi.org/10.1210/jcem.81.1.8550757.

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Allen, David B. "Sense and sensitivity: assessing inhaled corticosteroid effects on the hypothalamic-pituitary-adrenal axis." Annals of Allergy, Asthma & Immunology 89, no. 6 (2002): 537–39. http://dx.doi.org/10.1016/s1081-1206(10)62097-2.

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Mitani, Akihisa, Aishah Azam, Chaitanya Vuppusetty, Kazuhiro Ito, Nicolas Mercado, and Peter J. Barnes. "Quercetin restores corticosteroid sensitivity in cells from patients with chronic obstructive pulmonary disease." Experimental Lung Research 43, no. 9-10 (2017): 417–25. http://dx.doi.org/10.1080/01902148.2017.1393707.

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Al-Zamil, Mustafa Kh, Natalia G. Kulikova, and Ekaterina S. Vasilieva. "Interstitial electrical nerve stimulation in combination with perineural injections of corticosteroids in the treatment of paresthetic meralgia." Russian Journal of Physiotherapy, Balneology and Rehabilitation 21, no. 3 (2022): 171–82. http://dx.doi.org/10.17816/rjpbr111791.

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Abstract (sommario):

BACKGROUND: Paresthetic meralgia is a neuropathy caused by compression, pinching or stretching of the lateral femoral cutaneous nerve between the inguinal ligament and the anterior superior iliac spine. AIM: to study the effectiveness of interstitial electrical nerve stimulation in combination with perineural corticosteroid injections in the treatment of paresthetic meralgia. MATERIALS AND METHODS: We observed 30 patients with bilateral paresthetic meralgia. All patients suffered from numbness, tingling, and pain in the lateral thighs. Our study included only patients with bilatera

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