Bibliografie tematiche / Conformal ablation

Letteratura scientifica selezionata sul tema "Conformal ablation"

Autore: Grafiati

Pubblicato: 1 giugno 2024

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Articoli di riviste sul tema "Conformal ablation":

Wang, Hongying, Shiqing Zhao, Jincheng Zou e Aili Zhang. "A New Conformal Penetrating Heating Strategy for Atherosclerotic Plaque". Bioengineering 10, n. 2 (26 gennaio 2023): 162. http://dx.doi.org/10.3390/bioengineering10020162.

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(1) Background: A combination of radiofrequency (RF) volumetric heating and convection cooling has been proposed to realize plaque ablation while protecting the endothelial layer. However, the depth of the plaque and the thickness of the endothelial layer vary in different atherosclerotic lesions. Current techniques cannot be used to achieve penetrating heating for atherosclerosis with two targets (the specified protection depth and the ablation depth). (2) Methods: A tissue-mimicking phantom heating experiment simulating atherosclerotic plaque ablation was conducted to investigate the effects of the control parameters, the target temperature (Ttarget), the cooling water temperature (Tf), and the cooling water velocity (Vf). To further quantitatively analyze and evaluate the ablation depth and the protection depth of the control parameters, a three-dimensional model was established. In addition, a conformal penetrating heating strategy was proposed based on the numerical results. (3) Results: It was found that Ttarget and Tf were factors that regulated the ablation results, and the temperatures of the plaques varied linearly with Ttarget or Tf. The simulation results showed that the ablation depth increased with the Ttarget while the protection depth decreased correspondently. This relationship reversed with the Tf. When the two parameters Ttarget and Tf were controlled together, the ablation depth was 0.47 mm–1.43 mm and the protection depth was 0 mm–0.26 mm within 2 minutes of heating. (4) Conclusions: With the proposed control algorithm, the requirements of both the ablation depth and the endothelium protection depth can be met for most plaques through the simultaneous control of Ttarget and Tf.

Sciubba, Daniel M., E. Clif Burdette, Jennifer J. Cheng, William A. Pennant, Joseph C. Noggle, Rory J. Petteys, Christopher Alix et al. "Percutaneous computed tomography fluoroscopy–guided conformal ultrasonic ablation of vertebral tumors in a rabbit tumor model". Journal of Neurosurgery: Spine 13, n. 6 (dicembre 2010): 733–79. http://dx.doi.org/10.3171/2010.5.spine09266.

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Object Radiofrequency ablation (RFA) has proven to be effective for treatment of malignant and benign tumors in numerous anatomical sites outside the spine. The major challenge of using RFA for spinal tumors is difficulty protecting the spinal cord and nerves from damage. However, conforming ultrasound energy to match the exact anatomy of the tumor may provide successful ablation in such sensitive locations. In a rabbit model of vertebral body tumor, the authors have successfully ablated tumors using an acoustic ablator placed percutaneously via computed tomography fluoroscopic (CTF) guidance. Methods Using CTF guidance, 12 adult male New Zealand White rabbits were injected with VX2 carcinoma cells in the lowest lumbar vertebral body. At 21 days, a bone biopsy needle was placed into the geographical center of the lesion, down which an acoustic ablator was inserted. Three multisensor thermocouple arrays were placed around the lesion to provide measurement of tissue temperature during ablation, at thermal doses ranging from 100 to 1,000,000 TEM (thermal equivalent minutes at 43°C), and tumor volumes were given a tumoricidal dose of acoustic energy. Animals were monitored for 24 hours and then sacrificed. Pathological specimens were obtained to determine the extent of tumor death and surrounding tissue damage. Measured temperature distributions were used to reconstruct volumetric doses of energy delivered to tumor tissue, and such data were correlated with pathological findings. Results All rabbits were successfully implanted with VX2 cells, leading to a grossly apparent spinal and paraspinal tissue mass. The CTF guidance provided accurate placement of the acoustic ablator in all tumors, as corroborated through gross and microscopic histology. Significant tumor death was noted in all specimens without collateral damage to nearby nerve tissue. Tissue destruction just beyond the margin of the tumor was noted in some but not all specimens. No neurological deficits occurred in response to ablation. Reconstruction of measured temperature data allowed accurate assessment of volumetric dose delivered to tissues. Conclusions Using a rabbit intravertebral tumor model, the authors have successfully delivered tumoricidal doses of acoustic energy via a therapeutic ultrasound ablation probe placed percutaneously with CTF guidance. The authors have thus established the first technical and preclinical feasibility study of controlled ultrasound ablation of spinal tumors in vivo.

Milos, Frank S., Matthew J. Gasch e Dinesh K. Prabhu. "Conformal Phenolic Impregnated Carbon Ablator Arcjet Testing, Ablation, and Thermal Response". Journal of Spacecraft and Rockets 52, n. 3 (maggio 2015): 804–12. http://dx.doi.org/10.2514/1.a33216.

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MacDonell, Jacquelyn, Niravkumar Patel, Sebastian Rubino, Goutam Ghoshal, Gregory Fischer, E. Clif Burdette, Roy Hwang e Julie G. Pilitsis. "Magnetic resonance–guided interstitial high-intensity focused ultrasound for brain tumor ablation". Neurosurgical Focus 44, n. 2 (febbraio 2018): E11. http://dx.doi.org/10.3171/2017.11.focus17613.

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Currently, treatment of brain tumors is limited to resection, chemotherapy, and radiotherapy. Thermal ablation has been recently explored. High-intensity focused ultrasound (HIFU) is being explored as an alternative. Specifically, the authors propose delivering HIFU internally to the tumor with an MRI-guided robotic assistant (MRgRA). The advantage of the authors’ interstitial device over external MRI-guided HIFU (MRgHIFU) is that it allows for conformal, precise ablation and concurrent tissue sampling. The authors describe their workflow for MRgRA HIFU delivery.

Peng, Zhen-Wei, Hui-Hong Liang, Min-Shan Chen, Yao-Jun Zhang, Ya-Qi Zhang e Wan Y. Lau. "Conformal radiofrequency ablation of hepatocellular carcinoma with a multi-pin bipolar system". Journal of Surgical Oncology 103, n. 1 (28 ottobre 2010): 69–74. http://dx.doi.org/10.1002/jso.21742.

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Sharma, Sunil, Ganesh Narayanasamy, Beata Przybyla, Jessica Webber, Marjan Boerma, Richard Clarkson, Eduardo G. Moros, Peter M. Corry e Robert J. Griffin. "Advanced Small Animal Conformal Radiation Therapy Device". Technology in Cancer Research & Treatment 16, n. 1 (8 luglio 2016): 45–56. http://dx.doi.org/10.1177/1533034615626011.

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We have developed a small animal conformal radiation therapy device that provides a degree of geometrical/anatomical targeting comparable to what is achievable in a commercial animal irradiator. small animal conformal radiation therapy device is capable of producing precise and accurate conformal delivery of radiation to target as well as for imaging small animals. The small animal conformal radiation therapy device uses an X-ray tube, a robotic animal position system, and a digital imager. The system is in a steel enclosure with adequate lead shielding following National Council on Radiation Protection and Measurements 49 guidelines and verified with Geiger-Mueller survey meter. The X-ray source is calibrated following AAPM TG-61 specifications and mounted at 101.6 cm from the floor, which is a primary barrier. The X-ray tube is mounted on a custom-made “gantry” and has a special collimating assembly system that allows field size between 0.5 mm and 20 cm at isocenter. Three-dimensional imaging can be performed to aid target localization using the same X-ray source at custom settings and an in-house reconstruction software. The small animal conformal radiation therapy device thus provides an excellent integrated system to promote translational research in radiation oncology in an academic laboratory. The purpose of this article is to review shielding and dosimetric measurement and highlight a few successful studies that have been performed to date with our system. In addition, an example of new data from an in vivo rat model of breast cancer is presented in which spatially fractionated radiation alone and in combination with thermal ablation was applied and the therapeutic benefit examined.

Chami, Perla, William Jarnagin, Ghassan K. Abou-Alfa, James Harding, Neal Kim, Haibo Lin, Maria El Homsi, Christopher Crane e Carla Hajj. "Non-Surgical Locoregional Therapies Alone or in Combination with Systemic Therapy in Patients with Hepatocellular Carcinoma". Cancers 15, n. 6 (14 marzo 2023): 1748. http://dx.doi.org/10.3390/cancers15061748.

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Hepatocellular carcinoma (HCC) is the most common primary liver cancer, representing the third-leading cause of cancer-related deaths worldwide. Curative intent treatment options for patients with HCC include liver transplantation, resection and ablation of small lesions. Other potentially curative therapies include cryoablation, microwave ablation and percutaneous alcohol injection. For locally advanced disease, different arterially directed therapies including transarterial chemoembolization and selective internal radiation therapy, plus external beam radiation including three-dimensional conformal radiation therapy, intensity-modulated radiation therapy, stereotactic body radiation therapy and proton beam therapy, are available or studied. Systemic therapies based on checkpoint inhibitors and tyrosine kinase inhibitors are available for the management of metastatic HCC and sometimes for locally advanced disease. Combinations of locoregional therapies with systemic drugs are currently the subject of several clinical trials.

Kouloulias, Vassilis, Eftychia Mosa, John Georgakopoulos, Kalliopi Platoni, Ilias Brountzos, Anna Zygogianni, Christos Antypas et al. "Three-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma in Patients Unfit for Resection, Ablation, or Chemotherapy: A Retrospective Study". Scientific World Journal 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/780141.

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Purpose. The purpose is to evaluate the feasibility, efficacy, and the toxicity of three-dimensional conformal radiotherapy (3DCRT) in patients with advanced hepatocelluar carcinoma (HCC) and inferior vena cava tumor thrombosis (IVCTT).Methods. Between 2007 and 2012, in a retrospective way, 9 patients (median age 69 years) with advanced HCC and IVCTT unfit for surgery, radiofrequency ablation, embolization, or chemotherapy were treated with three-dimensional conformal radiotherapy (3DCRT). The radiotherapy volume included both primary tumor and IVTT. The radiotherapy schedule was 50–52 Gy in 2 Gy fractions. Overall survival (OS), response to radiotherapy, visual analogue scale (VAS), and toxicity were assessed.Results. All patients demonstrated a response rate up to 60%. During radiotherapy, 3 patients experienced grade 1 nausea/vomit toxicity. All patients demonstrated an elevation of the liver enzymes (3 patients with grade 1 and 6 patients with grade 2). The mean VAS-score was decreased from 6.11 to 3.11, while the median overall survival was 24 months.Conclusion. 3DCRT achieves a very high local control rate and is suitable for patients with HCC and IVTT, while the documented radiation induced toxicity is moderate. It can be recommended for palliation in patients unable to undergo curative therapies.

Chockalingam, Arun, Menelaos Konstantinidis, Brandon Koo, John Timothy Moon, Andrew Tran, Sahar Nourouzpour, Emily Lawson et al. "Surgical resection, radiotherapy and percutaneous thermal ablation for treatment of stage 1 non-small cell lung cancer: protocol for a systematic review and network meta-analysis". BMJ Open 12, n. 6 (giugno 2022): e057638. http://dx.doi.org/10.1136/bmjopen-2021-057638.

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IntroductionNon-small cell lung cancer (NSCLC) makes up the majority of lung cancer cases. Currently, surgical resection is the gold standard of treatment. However, as patients are becoming medically more complex presenting with advanced disease, minimally invasive image-guided percutaneous ablations are gaining popularity. Therefore, comparison of surgical, ablative and second-line external beam therapies will help clinicians, as management of NSCLC changes. We will conduct a meta-analysis, reviewing literature investigating these therapies in adult patients diagnosed with stage 1 NSCLC, with neither hilar nor mediastinal nodal involvement, confirmed either through cytology or histology regardless of type.Methods and analysisWe will search electronic databases (MEDLINE, Embase, Web of Science, Scopus, ClinicalTrials.gov, Cochrane) from their inception to January 2021 to identify randomised controlled trials (RCTs), cluster RCTs and cohort studies comparing survival and clinical outcomes between any two interventions (lobectomy, wedge resection, video-assisted thoracoscopic surgery/robot-assisted thoracoscopic surgery, radiofrequency ablation, microwave ablation, cryoablation and consolidated radiation therapies (external beam radiation therapy, stereotactic body radiation therapy, and 3D conformal radiation therapy). The primary outcomes will include cancer-specific survival, lung disease-free survival, locoregional recurrence, death, toxicity and non-target organ injury. We will also search published and unpublished studies in trial registries and will review references of included studies for possible inclusion. Risk of bias will be assessed using tools developed by the Cochrane collaboration. Two reviewers will independently assess the eligibility of studies and conduct the corresponding risk of bias assessments. For each outcome, given enough studies, we will conduct a network meta-analysis. Finally, we will use the Confidence in Network Meta-Analysis tool to assess quality of the evidence for each of the primary outcomes.Ethics and disseminationWe aim to share our findings through high-impact peer review. As interventional techniques become more popular, it will be important for providers in multidisciplinary teams caring for these patients to receive continuing medical education related to these interventions. Data will be made available to readers.PROSPERO registration numberCRD42021276629.

Kreidieh, Malek, Youssef H. Zeidan e Ali Shamseddine. "The Combination of Stereotactic Body Radiation Therapy and Immunotherapy in Primary Liver Tumors". Journal of Oncology 2019 (28 aprile 2019): 1–13. http://dx.doi.org/10.1155/2019/4304817.

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Treatment recommendations for primary liver malignancies, including hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), are complex and require a multidisciplinary approach. Despite surgical options that are potentially curative, options for nonsurgical candidates include systemic therapy, radiotherapy (RT), transarterial chemoembolization (TACE), and radiofrequency ablation (RFA). Stereotactic Body Radiation Therapy (SBRT) is now in routine use for the treatment of lung cancer, and there is growing evidence supporting its use in liver tumors. SBRT has the advantage of delivering ablative radiation doses in a limited number of fractions while minimizing the risk of radiation-induced liver disease (RILD) through highly conformal treatment plans. It should be considered in a multidisciplinary setting for the management of patients with unresectable, locally advanced primary liver malignancies and limited treatment options. Recently, the combination of immunotherapy with SBRT has been proposed to improve antitumor effects through engaging the immune system. This review aims at shedding light on the novel concept of the combination strategy of immune-radiotherapy in liver tumors by exploring the evidence surrounding the use of SBRT and immunotherapy for the treatment of HCC and CCA.

Più fonti

Tesi sul tema "Conformal ablation":

Núñez, García Marta. "Left atrial parameterisation and multi-modal data analysis: application to atrial fibrillation". Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/664138.

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Many aspects related to the pathogenesis and progression of atrial fibrillation (AF) are still not fully understood. In this thesis we have contributed with (1) an automatic framework to segment the left atrium (LA) from late gadolinium enhancement magnetic resonance imaging (LGE-MRI) data, (2) a framework for obtaining a standardised two-dimensional representation of the left atrial cavity, and (3) a methodology to detect and measure the incompleteness of ablation lesions after pulmonary vein isolation (PVI). Finally, we applied our tools to real clinical datasets showing how our methods can be transferred and included into clinical research practice. We investigated the regional distribution of gaps in a cohort of AF patients who undergone radiofrequency PVI, the reproducibility of scar imaging with LGE-MRI, the intra- and inter-observer variability of manual LA segmentation tools, the preferential regional distribution of fibrosis in AF patients, and the relation between electroanatomical information and LGE-MRI data.
Muchos aspectos relacionados con la patogénesis y progresión de la fibrilación auricular (FA) son todavía desconocidos. En esta tesis, hemos propuesto (1) un método para segmentar la aurícula izquierda (AI) en datos de resonancia magnética con realce tardío por gadolinio (LGE-MRI), (2) un framework para obtener una representación bidimensional estandarizada de la aurícula izquierda, y (3) una técnica para detectar y medir la incompletitud (gaps) de las lesiones de ablación después del aislamiento de las venas pulmonares (PVI). Finalmente, hemos aplicado nuestras herramientas a datos clínicos reales mostrando cómo nuestros métodos pueden transferirse e incluirse en investigación clínica. Concretamente, hemos investigado la distribución regional de gaps en pacientes con FA, la reproducibilidad de detección de cicatriz con LGE-MRI, la variabilidad intra e inter-observador de las herramientas de segmentación manual de AI, la distribución regional de fibrosis en pacientes con FA, y la relación entre la información electroanatómica y LGE-MRI.

Velghe, Anthony Chassaing Patrick. "Modélisation de l'interaction entre un écoulement turbulent et une paroi ablatable". Toulouse : INP Toulouse, 2008. http://ethesis.inp-toulouse.fr/archive/00000539.

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Daunizeau, Loïc. "Développement de la thérapie ultrasonore conformationnelle par voie interstitielle pour le traitement du carcinome hépatocellulaire". Electronic Thesis or Diss., Lyon, 2020. http://www.theses.fr/2020LYSE1326.

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Le carcinome hépatocellulaire est le principal cancer primaire du foie. Les procédures d’ablation thermique par voie interstitielle constituent un type de traitement curatif de ce cancer. Ces méthodes ne permettent pas toujours, de par leur nature physique (radio fréquence, micro-onde, laser, cryothérapie), de générer une ablation conformationnelle pour un volume tumoral donné. Dans certains cas, cela peut entraîner l’ablation d’un volume important de tissus non tumoraux. L'utilisation d'une sonde interstitielle ultrasonore disposant d’un transducteur avec de nombreux éléments indépendants, capable de générer des ultrasons focalisés de haute intensité (HIFU), permettrait théoriquement de lever cette limitation. D’autre part, le nombre élevé d’éléments permettrait également de disposer de capacités d’imagerie. Les travaux présentés dans cette thèse ont donc d’abord porté sur la conception du transducteur associé à ce type de sonde. Un design particulier a été proposé spécifiquement pour le traitement d’une tumeur de 4 cm de diamètre. S’est ensuite posé la question de la stratégie de planification du traitement à adopter pour obtenir une lésion la plus conformationnelle possible. Différentes stratégies ont été évaluées par simulations numériques. Toutes ont présentés des caractéristiques semblables tant en termes de conformation que de temps de traitement total. La focalisation ultrasonore s’est avérée en elle-même suffisante pour générer un traitement conformationnel. Finalement, une plateforme robotique a été développée pour le pilotage de prototypes de sondes ultrasonores interstitielles bimodales, aussi bien en mode imagerie qu’en mode thérapie. Cette plateforme a permis de réaliser in vitro, les planifications de traitement automatiques de plusieurs fantômes de tumeurs, en se basant sur la reconstruction ultrasonore 3D issue de l’imagerie échographique obtenue in situ par les sondes ultrasonores. En revanche, en mode thérapie les prototypes de sondes n’ont pas atteint leurs spécifications et n’ont pas réussi à générer des lésions thermiques dans des tissus hépatiques in vitro. La modularité de la plateforme robotique a rendu possible son utilisation avec un système de thérapie ultrasonore différent, à la fiabilité éprouvé. Avec ce système, la planification automatique du traitement, ainsi que l’exécution du traitement HIFU associé, ont pu être effectué in vitro avec succès par la plateforme
Hepatocellular carcinoma is the most common primary cancer of the liver. Interstitial thermal ablation procedures constitute a type of curative treatments for this cancer. Given the physical nature of the phenomenon used to modify temperature (radio frequency, micro wave, laser, cryotherapy), those methods may not be able to generate a conformal treatment for a given tumor shape. In some cases, this limitation may induce the thermal ablation of a large volume of non-tumor tissues. The use of an ultrasound interstitial probe mounted with a multi-element transducer capable of generating high intensity focused ultrasound (HIFU) may theoretically help to overcome this limitation. Also a transducer with an important number of elements may also provide in situ imaging. As a first step, the design of a transducer for interstitial ultrasound probe was studied. A specific configuration has been proposed for the treatment of tumors with a diameter of 4 cm. The question of the treatment planning method to adopt to reach an optimal conformal treatment has been then addressed by comparing numerical simulations of different strategies. All strategies were sufficiently conformal and none presented real assets compared to the others. Ultrasound focusing in itself provided the desired conformal thermal ablation. Finally, a robotic platform was developed for driving interstitial dual mode ultrasound probes, both in imaging and in therapy mode. This platform allowed the automatic treatment planning of in vitro tumor mimic phantoms, based on 3D ultrasound reconstruction from the B mode images obtained in situ by the interstitial probe. However, in therapy mode, the probes did not reach their specifications and did not manage to create thermal lesions in in vitro liver tissue sample. The modularity of the robotic platform allowed driving a different HIFU system, which was more robust. With this system, the platform managed to perform with success an automatic treatment planning and then the associated HIFU treatment in in vitro tissue sample

Velghe, Anthony. "Modélisation de l'interaction entre un écoulement turbulent et une paroi ablatable". Phd thesis, Toulouse, INPT, 2007. http://oatao.univ-toulouse.fr/7631/1/velghe.pdf.

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Lorsqu'une sonde rentre dans l'atmosphère à une vitesse hypersonique, le bouclier thermique reçoit plusieurs centaines de MW/m2. Ce flux est absorbé par la paroi (composite C/C) grâce à des réactions physico-chimiques (oxydation, sublimation). Cette perte de matière entraîne une récession du matériau et nous pouvons remarquer la formation d'une rugosité en régime turbulent. Dans ce contexte, cette étude a pour objectif de caractériser à la plus petite échelle de la turbulence (échelle de Kolmogorov), l'interaction entre un écoulement turbulent et une paroi ablatable afin de comprendre la formation des rugosités. Une première étude a permis de modéliser l'état de surface d'un matériau carbone soumis au phénomène de réaction-diffusion et de proposer des états de surface analogue aux expériences. Puis, le développement d'un code de simulation numérique directe intégrant une transformation conforme exacte, permet de suivre l'évolution structurelle du matériau ablaté couplé à un champ de vitesse turbulent. Les simulations réalisées démontrent l'interaction forte de la turbulence sur la formation des rugosités à la surface d'un matériau ablatable.

Fitzgerald, Rhys J. "A comparison of volumetric modulated arc therapy (VMAT), intensity modulated radiation therapy (IMRT) and 3-dimensional conformal radiation therapy (3DCRT) for stereotactic ablative radiation therapy (SABR) for early stage lung cancer". Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/99826/4/Rhys_Fitzgerald_Thesis.pdf.

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This thesis is a comparative study looking at different radiation therapy treatment techniques for treating early stage lung cancer. It investigated three different techniques that had differing number of beams and treatment angles. Furthermore, it also look at beams that rotated, against beams that were stationary. It was discovered that multiple beams that continuously rotate around the patient provided optimal dose to the tumour, minimum dose to surrounding healthy tissues and had the quickest delivery time.

Capitoli di libri sul tema "Conformal ablation":

Feldmann, H. J., P. Stoll, H. Geinitz e F. B. Zimmermann. "Prostate Cancer - Combination of Hormonal Ablation and Conformal Therapy". In Three-Dimensional Radiation Treatment, 165–76. Basel: KARGER, 2000. http://dx.doi.org/10.1159/000061265.

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Gomez, Daniel, Peter Balter e Zhongxing Liao. "Stereotactic Ablative Body Radiation (SABR) and Postoperative Radiation in Non-Small Cell Lung Cancer (NSCLC)". In Target Volume Delineation for Conformal and Intensity-Modulated Radiation Therapy, 241–50. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/174_2014_994.

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R. Mong, Eric, e Daniel K. Fahim. "Minimally Invasive Treatment of Spinal Metastasis". In Minimally Invasive Spinal Fusion [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.102485.

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Advancements in the treatment of systemic cancer have improved life expectancy in cancer patients and consequently the incidence of spinal metastasis. Traditionally, open spinal approaches combined with cEBRT (conventional external beam radiation therapy) allowed for local tumor control as well as stabilization and decompression of the spine and neural elements, but these larger operations can be fraught with one complications and delayed healing as well as additional morbidity. Recently, minimally invasive spine techniques are becoming increasingly popular in the treatment of spinal metastasis for many reasons, including smaller incisions with less perioperative complications and potential for expedited time to radiation therapy. These techniques include kyphoplasty with radiofrequency ablation, percutaneous stabilization, laminectomy, and epidural tumor resection through tubular retractors, as well as minimally invasive corpectomy. These techniques combined with highly conformal stereotactic radiosurgery have led to the advent of separation surgery, which allows for decompression of neural elements while creating space between neural elements and the tumor so adequate radiation may be delivered, improving local tumor control. The versatility of these minimally invasive techniques has significantly improved the modern management of metastatic disease of the spine by protecting and restoring the patient’s quality of life while allowing them to quickly resume radiation and systemic treatment.

Atti di convegni sul tema "Conformal ablation":

Deng, Zhong-Shan, Jing Liu e Ji-Ren Zhang. "Conformal RF Ablation to Reduce “Dead Region” With Adjuvant Injection of Magnetic Micro/Nano Particles: Feasibility Study". In 2007 First International Conference on Integration and Commercialization of Micro and Nanosystems. ASMEDC, 2007. http://dx.doi.org/10.1115/mnc2007-21267.

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Radiofrequency (RF) ablation is a minimally invasive technique for tumor treatment. Intended benefits of oncological RF ablation include the availability of tumor treatment in nonsurgical candidate, minimal risk to patient, reduced morbidity and shorter recovery period compared with those after conventional surgery, and the potential for treatment on an outpatient basis. RF ablation, by producing heat energy that raises the temperature of the target tissue to a degree sufficient to cause thermally mediated coagulation necrosis, has been shown to be remarkably effective for thermal ablation of small tumors. Although RF hyperthermia has been successful in ablating small tumors, further optimization of the ablation technique is required to induce the larger volumes of coagulation that are necessary to treat larger tumors. In addition, due to the extremely irregular shape of tumor in clinics, the conventional RF ablation technique is hard to produce a conformal lesion to exactly enwrap the tumor as could as possible. This may lead to “dead region” within the area between RF probes and thus a failed treatment. To obtain a conformal treatment of complex tumor, strategies to flexibly control the size and shape of the ablated zone are desired.

Audigier, Chloé, Younsu Kim, Jens Ziegle, Michael Friebe e Emad M. Boctor. "Conformal radiofrequency ablation to validate ultrasound thermometry". In Image-Guided Procedures, Robotic Interventions, and Modeling, a cura di Baowei Fei e Cristian A. Linte. SPIE, 2019. http://dx.doi.org/10.1117/12.2512788.

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Milos, Frank S., e Matthew Gasch. "Conformal Phenolic Impregnated Carbon Ablator (C-PICA) Arcjet Testing, Ablation and Thermal Response". In 53rd AIAA Aerospace Sciences Meeting. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2015. http://dx.doi.org/10.2514/6.2015-1448.

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Burdette, E. Clif, Filip Banovac, Chris J. Diederich, Patrick Cheng, Emmanuel Wilson e Kevin R. Cleary. "Conformal needle-based ultrasound ablation using EM-tracked conebeam CT image guidance". In SPIE BiOS, a cura di Thomas P. Ryan. SPIE, 2011. http://dx.doi.org/10.1117/12.876550.

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Makin, I. R. "Conformal Bulk Ablation And Therapy Monitoring Using Intracorporeal Image-Treat Ultrasound Arrays". In 4TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND. AIP, 2005. http://dx.doi.org/10.1063/1.1901591.

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Kinsey, Adam M., Chris J. Diederich, William H. Nau, Anthony B. Ross, Kim Butts Pauly, Viola Rieke e Graham Sommer. "Fast Conformal Thermal Ablation in the Prostate with Transurethral Multi-Sectored Ultrasound Devices and MR Guidance". In 6TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND. AIP, 2007. http://dx.doi.org/10.1063/1.2744304.

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Sidor, Adam T., Robert D. Braun e Graeme Kennedy. "Methodology for Optimal Design of a Conformal Ablative Heatshield". In 2018 Joint Thermophysics and Heat Transfer Conference. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2018. http://dx.doi.org/10.2514/6.2018-4178.

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Sidor, Adam T., Robert D. Braun, Robin A. Beck e Margaret M. Stackpoole. "Vacuum Infusion Process Development for Conformal Ablative Thermal Protection System Materials". In AIAA SPACE and Astronautics Forum and Exposition. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2017. http://dx.doi.org/10.2514/6.2017-5199.

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Gasch, Matthew, Mairead Stackpoole, Susan White e Tane Boghozian. "Development of Advanced Conformal Ablative TPS Fabricated from Rayon- and Pan-Based Carbon Felts". In 57th AIAA/ASCE/AHS/ASC Structures, Structural Dynamics, and Materials Conference. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2016. http://dx.doi.org/10.2514/6.2016-1414.

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Balbinotti, Rodrigo Rossi, Leticia Maria de Lima Pessoa, Julyana Lunardi Mousquer, Renata Rauber Felkl, Debora Stefanello e Thabata Chiele. "Jato de plasma no tratamento de lesões vulvares por papilomavírus humano". In 46º Congresso da SGORJ e Trocando Ideias XXV. Zeppelini Editorial e Comunicação, 2022. http://dx.doi.org/10.5327/jbg-0368-1416-2022132s1114.

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Abstract (sommario):

Introdução: As neoplasias intraepiteliais de vulva (NIV) caracterizam-se por displasia com atipia epitelial. Relacionam-se à infecção pelo papilomavírus humano (HPV) e a cofatores como o tabagismo e imunodeficiência. Classificam-se em NIV 1, 2 ou 3, conforme o grau de alteração histológica. As duas últimas são lesões pré-malignas, enquanto para a NIV 1 faltam evidências de que seja precursora do câncer. O tratamento para NIV consiste na destruição local ou excisão, devendo ser individualizado conforme a localização e o tamanho da lesão. Este relato visou descrever o tratamento de uma NIV 1 com jato de plasma, uma modalidade nova de terapia baseada em energia. Relato de caso: Mulher de 63 anos fazia acompanhamento por lesão vulvar, cuja biópsia diagnosticou líquen plano. Recebeu prescrição de pomada de clobetasol por um mês, porém no retorno relatava prurido e queimação. À vulvoscopia com magnificação, viu-se área acetobranca no sulco interlabial esquerdo e na face externa do pequeno lábio direito. Biopsiadas, revelaram NIV 1. A paciente retornou após quatro semanas referindo piora do prurido e surgimento de bolinhas na vulva, que correspondiam a lesões verrucosas no introito vaginal e na região perianal. Nessa ocasião foi realizada a primeira aplicação de jato de plasma nas lesões vulvares. Depois de quatro semanas a paciente retornou apresentando lesão com aspecto infiltrativo na face interna do pequeno lábio esquerdo, cuja biópsia evidenciou NIV 1. Foram realizadas mais duas aplicações de jato de plasma e, em 60 dias, foi reiniciado o clobetasol. A paciente retornou sem sintomas e remissão das lesões vulvares. Conclusão: Casos de NIV 1 podem representar alterações reativas benignas do epitélio ao HPV, não sendo observada progressão para NIV 3. O objetivo do tratamento das lesões condilomatosas é a redução da carga viral e, assim, da transmissibilidade. Todas as NIV 2 e 3 devem ser tratadas, visando reduzir a progressão para carcinoma. Excisão ampla pode ser necessária se não for possível excluir carcinoma invasivo, mas tratamentos ablativos podem ser considerados para a preservação estética e funcional. Tratamentos com laser podem ser dolorosos. Tratamento tópico com imiquimode apresenta boas taxas de regressão. Alternativas relacionadas às energias são promissoras. No caso relatado, a diminuição da imunidade local promovida pelo tratamento com corticoide parece ter favorecido o surgimento de lesões condilomatosas. Utilizou-se um subtipo de radiofrequência que é de fácil aplicação em regime ambulatorial, agindo por meio de ablação do epitélio pelo calor, além de outros possíveis benefícios como estimulação da cicatrização e renovação celular. Nosso relato evidencia um resultado satisfatório com poucas aplicações, sugerindo se tratar de uma alternativa eficaz no manejo dessas lesões que são, muitas vezes, refratárias e recidivantes. São necessários estudos observacionais e comparativos para a comprovação da aplicabilidade do método nessa indicação.