Letteratura scientifica selezionata sul tema "Conception de médicaments assistée par ordinateur"
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Articoli di riviste sul tema "Conception de médicaments assistée par ordinateur"
Vanhelst, Pierre. "Conception assistée par ordinateur et relations acheteur-fournisseur". Décisions Marketing 4 (1 gennaio 1995): 73–78. http://dx.doi.org/10.7193/dm.004.73.78.
Testo completoBarache, J. M., G. Beltranda, P. Blanc e J. Pinoteau. "VII - Les moyens de conception assistée par ordinateur". Revue Générale Nucléaire, n. 2 (marzo 1987): 198–200. http://dx.doi.org/10.1051/rgn/19872198.
Testo completoVanhelst, Pierre. "Conception assistée par ordinateur et relations acheteur-fournisseur". Décisions Marketing N° 4, n. 1 (1 gennaio 1995): 73–78. http://dx.doi.org/10.3917/dm.04.0073.
Testo completoRumelhard, Christian, Yves Archambault e Isabelle Telliez. "Conception assistée par ordinateur des circuits intégrés monolithiques hyperfréquences". Annales des Télécommunications 43, n. 7-8 (luglio 1988): 434–42. http://dx.doi.org/10.1007/bf02999713.
Testo completoHégron, Gérard. "De la modélisation à la conception assistée par ordinateur". Annales des Ponts et Chaussées 2003, n. 107-108 (luglio 2003): 19–26. http://dx.doi.org/10.1016/s0152-9668(03)80004-9.
Testo completodeVathaire, M., E. Liégeon, G. Mennel e A. Faesse. "Conception assistée par ordinateur : application au laminage des produits longs". Revue de Métallurgie 82, n. 5 (maggio 1985): 387–98. http://dx.doi.org/10.1051/metal/198582050387.
Testo completoLincelles, JB, V. Goiffon e M. Respauda. "Apprentissage de la conception de circuits intégrés : une introduction par la technologie à l’aide d’un logiciel de TCAD". J3eA 21 (2022): 1010. http://dx.doi.org/10.1051/j3ea/20221010.
Testo completoSatori, K., e B. El Kihel. "Étude et modélisation des mécanismes complexes en conception assistée par ordinateur". Journal de Physique III 7, n. 11 (novembre 1997): 2211–23. http://dx.doi.org/10.1051/jp3:1997253.
Testo completoTap, H., R. P. Tan, O. Bernal, P.-F. Calmon, C. Rouabhi, C. Capello, J. Schauber et al. "Du silicium au circuit CMOS. Pédagogie active par Apprentissage Par Projet". J3eA 23 (2024): 1019. http://dx.doi.org/10.1051/j3ea/20241019.
Testo completoRagavan, R., A. Laferrière, D. Dumont, P. Rondot, P. Benoît e F. Ohanna. "Les coussins anti-escarres de type ≪conception assistée par ordinateur≫: Expérience préliminaire". Annales de Réadaptation et de Médecine Physique 40, n. 6 (gennaio 1997): 419–20. http://dx.doi.org/10.1016/s0168-6054(97)85418-9.
Testo completoTesi sul tema "Conception de médicaments assistée par ordinateur"
Minoux, Hervé. "Étude et conception assistées par ordinateur d'antagonistes des intégrines de la famille beta 3". Nancy 1, 1998. http://www.theses.fr/1998NAN10260.
Testo completoSperandio, Olivier. "Applications et développements informatiques de protocoles de drug design et criblage virtuel". Paris 5, 2007. http://www.theses.fr/2007PA05P612.
Testo completoThis thesis in structural bioinformatics and chemoinformatics concentrates on the optimization of the therapeutics compounds identification process. It relies on the three main components of the chemical compounds virtual screening: preparation of a computational version of the chemical library to be screened; identification of novel active compounds using chemical similarity with respect to known active molecules (LBVS); and identification of novel active compounds using the 3D structure of the target binding site (SBVS). This work implied: to develop a computer program (MED-3DMC) that generates conformation ensembles of small molecules ; then to create a LBVS program (MED-SuMoLig) that can screen thousands of chemical compounds using their pharmaco-topological profile; and finally to use a hierarchical SBVS procedure to identify novel inhibitors for protein-membrane interaction using the coagulation factor Va as a proof of concept
Muller, Pascal. "Criblage virtuel inverse : validation et applications". Strasbourg 1, 2006. http://www.theses.fr/2006STR13137.
Testo completoThe conception of bioactive molecules uses more and more in silico methods. Discovering which ligands, out of a large library, are likely to bind to a protein of interest is slowly turning into routine computational chemistry. Surprisingly, the opposite question is still an issue. Given a known ligand, is it possible to recover its most likely target(s)? Answering this question using the above mentioned docking approach implies the development of a collection of protein active sites. As a database of choice to develop the inverse virtual screening (IVS) procedure, we have chosen the Protein Data Bank. We extracted from the PDB a target library, the sc-PDB. It is a collection of three-dimensional structures of active sites. I contributed to validate the IVS procedure: it is able to find known targets of ligands. In the process of sc-PDB update, I developed an algorithm able to accurately identify protein-ligand complex. I used IVS procedure to discover targets for new molecules: chemists wanted to know if the chemical space of their combinatorial library matches pharmaceutical targets. Five targets were selected in silico, and two targets were validated in vitro. The sc-PDB library and IVS procedure are powerful tools, and the simplicity of the approach makes it particularly attractive for prioritizing a few targets for experimental validation, and is therefore a good complement to experimental target identification strategies
Hoffer, Laurent. "Développement et validation du logiciel S4MPLE : application au docking moléculaire et à l'optimisation de fragments assistée par ordinateur dans le cadre du fragment-based drug design". Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-00874644.
Testo completoConvard, Thomas. "Conception assistée par ordinateur en environnement immersif". Paris 11, 2005. http://www.theses.fr/2005PA112249.
Testo completoThis thesis discuss of the use of immersive environments of Virtual Reality (VR) for Computer Aided Design (CAD). We study how these new interfaces between man and information systems can improve the different tasks of geometric shape design that are actually done on workstation with screen. These workstations essentially use keyboard, mouse and graphical interface. However this kind of interaction does not take advantage of VR possibilities in term of direct 3d interaction. In addition, CAD objects does not allow ways to modify there shape with a direct and 3d interaction. We present an approach of reactive objects that allows changing the value of operations parameters in the construction history graph of the solid, from direct interaction of the user on the elements (vertex, edge, face) of the B-Rep of the solid. To this purpose, we use an inference system that decides what parameters to modify knowing the selected element, and how to map the manipulations of the user to numerical changes of the parameters. These inferences are based on sets of rules dealing with construction information attached to the elements of B-Rep. This model of reactive objects has been implemented in a software prototype allowing creation and modification of CAD objects in an intuitive way. The interface proposed is a multimodal and immersive environment. We also propose in this thesis a method for collision detection dedicated to immersive interaction and a graphic rendering system on PC cluster adapted to deformable objects
Touir, Maatallah. "Conception des canaux assistée par ordinateur CCAO". Master's thesis, Université Laval, 1996. http://hdl.handle.net/20.500.11794/28418.
Testo completoFarag, Marc. "Conception assistée par ordinateur d'inhibiteurs de XIAP". Electronic Thesis or Diss., Normandie, 2023. http://www.theses.fr/2023NORMC264.
Testo completoSince their discovery, protein-protein interactions (PPIs) have been at the heart of many biological processes. These PPIs can be drug targets, either by mimicking a defective interaction or by inhibiting an inadequate interaction. Among the most implicated PPIs in pathologies, we found the Inhibitor Apoptosis Proteins (AAPs). These members are considered as key regulators of programmed cell death and, within the cell signalling pathways, XIAP, a member of the IAP family, is one of the most targeted proteins actually. Its involvement in cancers and rare inflammatory diseases makes it a therapeutic target of choice. Recent data in the literature have highlighted the importance of designing selective disruptors for this protein in order to avoid serious adverse effects. For this reason, it is essential to know the essential structural elements associated with the different domains of this protein, which distinguish it from other similar members of the IAP family. It is also essential to know the interaction mechanisms in which XIAP is involved with its partners. CADD tools, in particular the Structure-based drug design approach, as well as experimental evaluation techniques using fluorescence anisotropy (FPA) or AlphaScreen® technology were used as part of this thesis work. The results of in silico and in vitro work led to rational design proposals of selective small molecules that could potentially disrupt XIAP-mediated PPIs
Seignole, Jean-François. "Conception assistée par ordinateur de liaisons par fibres optiques". Limoges, 1991. http://www.theses.fr/1991LIMO0115.
Testo completoDelchambre, Alain. "Conception assistée par ordinateur de gammes opératoires d'assemblage". Doctoral thesis, Universite Libre de Bruxelles, 1990. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/213146.
Testo completoTayyar, Ahmad. "Une méthode de géodésie assistée par ordinateur". Mulhouse, 1991. http://www.theses.fr/1991MULH0199.
Testo completoLibri sul tema "Conception de médicaments assistée par ordinateur"
Paul, Quintrand, a cura di. La Conception assistée par ordinateur en architecture. Paris: Hermès, 1985.
Cerca il testo completoLoyer, Michel. La CAO - Le DAO. Paris: Presses universitaires de France, 1991.
Cerca il testo completoRisler, Jean-Jacques. Méthodes mathématiques pour la CAO. Paris: Masson, 1991.
Cerca il testo completoBoulicot, Claude. C.A.O.: Choix, mise en place et pratique. Paris: Eyrolles, 1989.
Cerca il testo completoRiopel, Martin. Conception et mises à l'essai d'un environnement d'apprentissage intégrant l'expérimentation assistée par ordinateur et la simulation assistée par ordinateur. [Repentigny, QC]: Martin Riopel, 2005.
Cerca il testo completoMeyer, J. J. 3 D et vrai relief: Images de synthèse. Paris: Editions Radio, 1986.
Cerca il testo completoVonk, Roland. Prototypage: L'utilisation efficace de la technologie CASE. Paris: Masson, 1992.
Cerca il testo completoLewis, T. G. CASE: Computer-aided software engineering. New York: Van Nostrand Reinhold, 1991.
Cerca il testo completoBonnardel, Nathalie. Créativité et conception: Approches cognitives et ergonomiques. Marseille: Solal, 2006.
Cerca il testo completoGordon, Bob. Le guide pratique du design graphique et numérique: Agrémenté de 531 illustrations. Paris: Pyramid, 2002.
Cerca il testo completoCapitoli di libri sul tema "Conception de médicaments assistée par ordinateur"
Arrué, J., B. Moreno e J. P. Chavoin. "Conception assistée par ordinateur et reconstruction des parois". In Chirurgie plastique et reconstructrice des parois et des confins, 39–56. Elsevier, 2009. http://dx.doi.org/10.1016/b978-2-294-70949-4.50003-7.
Testo completoAtti di convegni sul tema "Conception de médicaments assistée par ordinateur"
Elmoutawakkil, N., S. Bouzoubaa, S. Bellemkhannate e I. Benyahya. "Flux de travail du guidage tridimensionnel en chirurgie orale". In 66ème Congrès de la SFCO. Les Ulis, France: EDP Sciences, 2020. http://dx.doi.org/10.1051/sfco/20206602005.
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