Letteratura scientifica selezionata sul tema "Composés organiques volatils – toxicité"
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Articoli di riviste sul tema "Composés organiques volatils – toxicité":
Gigon, F. "Focus sur l’utilisation des huiles essentielles (HE) en diffusion aérienne. Quoi de nouveau sur la tolérance des HE dans l’air ambiant ?" Phytothérapie 17, n. 3 (18 aprile 2019): 116–19. http://dx.doi.org/10.3166/phyto-2019-0130.
Jusseaume, Valérie, Céline Kutek e Fabrizio Annocaro. "Détection de l’exposition aux composés organiques volatils (COV)". Archives des Maladies Professionnelles et de l'Environnement 81, n. 5 (ottobre 2020): 685. http://dx.doi.org/10.1016/j.admp.2020.03.664.
Cicolella, A. "Les composés organiques volatils (COV) : définition, classification et propriétés". Revue des Maladies Respiratoires 25, n. 2 (febbraio 2008): 155–63. http://dx.doi.org/10.1016/s0761-8425(08)71513-4.
Cicolella, A. "Les composés organiques volatils (COV) : définition, classification et propriétés." Revue des Maladies Respiratoires 25, n. 2 (febbraio 2008): 258. http://dx.doi.org/10.1016/s0761-8425(08)71530-4.
Cicolella, A. "Les composés organiques volatils (COV) : définition, classification et propriétés." Revue des Maladies Respiratoires 25, n. 2 (febbraio 2008): 262. http://dx.doi.org/10.1016/s0761-8425(08)71538-9.
Palot, A., C. Charpin-Kadouch, J. Ercoli e D. Charpin. "Composés organiques volatils intérieurs : concentrations, sources, facteurs de variabilité". Revue des Maladies Respiratoires 25, n. 6 (giugno 2008): 725–30. http://dx.doi.org/10.1016/s0761-8425(08)73801-4.
Palot, A., C. Charpin-Kadouch, J. Ercoli e D. Charpin. "Composés organiques volatils intérieurs : concentrations, sources, facteurs de variabilité." Revue des Maladies Respiratoires 25, n. 6 (giugno 2008): 775. http://dx.doi.org/10.1016/s0761-8425(08)73809-9.
Palot, A., C. Charpin-Kadouch, J. Ercoli e D. Charpin. "Composés organiques volatils intérieurs : concentrations, sources, facteurs de variabilité." Revue des Maladies Respiratoires 25, n. 6 (giugno 2008): 779. http://dx.doi.org/10.1016/s0761-8425(08)73816-6.
Soualeh, N., e R. Soulimani. "Huiles essentielles et composés organiques volatils, rôles et intérêts". Phytothérapie 14, n. 1 (febbraio 2016): 44–57. http://dx.doi.org/10.1007/s10298-016-1024-9.
Casset, A., e F. de Blay. "Effets sur la santé des composés organiques volatils de l’habitat". Revue des Maladies Respiratoires 25, n. 4 (aprile 2008): 475–85. http://dx.doi.org/10.1016/s0761-8425(08)71587-0.
Tesi sul tema "Composés organiques volatils – toxicité":
Pelletier, Maud. "Expositions agrégées aux composés organiques semi-volatils dans l'habitat et risques sanitaires associés". Thesis, Rennes 1, 2017. http://www.theses.fr/2017REN1B028/document.
In housing, people are exposed to an increasing number of chemicals, including semivolatile organic compounds (SVOCs). SVOCs are present on surfaces, in the gas phase, airborne particles and settled dust. Humans are exposed through ingestion, inhalation and dermal contact. Many of these compounds have suspected toxic effects on human health. The objective of this thesis is to assess, by a risk assessment approach, the public health risk posed by the exposure to SVOCs frequently detected in French dwellings. At first, indoor exposures were estimated for 32 compounds from contamination data and human parameters such as body weight, inhalation rate, time spent in dwellings etc. Ingestion, inhalation and dermal contact exposure pathways were aggregated for the indoor SVOCs of greatest concern and for several age groups from birth to age 30. In a second step, human health risks were modeled from these exposures and from available toxicity data. Each SVOC was considered separately and also in mixtures, based on the assumption of dose additivity. This work provided exposures distributions representative of the French population and identified the dominant media and exposure routes for each compound as well as the most at risk SVOCs for a certain portion of the French population
Godefroy, Isabelle. "Importance et aspects sanitaires des composés organohalogènes volatils dans l'eau et les atmosphères de piscines". Paris 5, 1988. http://www.theses.fr/1988PA05P273.
Fournier, Kevin. "Construction d'indicateurs de toxicites cumulees : cas des composes organiques semi volatils dans les environnements interieurs". Thesis, Rennes 1, 2015. http://www.theses.fr/2015REN1B019/document.
Semi-volatile organic compounds (SVOCs) are widely present in indoor environments and are suspected to be repro- or neurotoxic but little is known on the health impact on SVOC mixtures. The objective of this work is to derive cumulative toxicity indicators for SVOCs detected in French dwellings in carrying forward a cumulative health risk assessment. SVOCs were grouped according to their repro- and neurotoxic common modes of action (i.e. decrease in serum testosterone concentrations, decrease in neuronal viability). Benchmark doses (BMDs) were then estimated by modeling dose-response relationships from scientific literature (Hill models, PROAST, RIVM). Comparable BMDs were estimated only for 6 of the 19 reprotoxic SVOCs which are responsible to 10 or 50% decrease in testosterone in adult male rats orally exposed. Estimated relative potency factors (RPFs) from BMDs are similar according to the response level (from 1600 for the B(a)P to 0.1 for the BBP), excepted for bisphenol A moving from 7E+6 to 180. For in vitro neuronal death, BMDs were estimated for 13 neurotoxic SVOCs using data from different cell lines and species. BMDs equivalent to a 10% of response range from 0.07 (PCB-153) to 95 µM (diazinon). The originality of this work is the grouping of compounds from different chemical families which we are really exposed to. BMDs estimation from published data was possible but many methodological limitations lead us to put forward recommendations especially on the standardization of experimental protocols and the availability of results in adapted format for dose-response relationship modeling
Méausoone, Clémence. "Etude en Interface Air-Liquide de la toxicité des Composés Organiques Volatils lors d’expositions répétées : Cas du toluène, de ses homologues et des émissions issues de son traitement catalytique". Thesis, Littoral, 2019. https://documents.univ-littoral.fr/access/content/group/50b76a52-4e4b-4ade-a198-f84bc4e1bc3c/BULCO/Th%C3%A8ses/Toxicologie/these_Meausoone_Clemence.pdf.
Toluene is a solvent widely used in manufacturing industries. It belongs to a family of volatile organic compounds (VOCs), many of which have adverse impacts on human health and are classified as carcinogenic, mutagenic or toxic for reproduction. Different measures have been implemented to reduce the emissions of toxic compounds, such as their replacement in the industry by less harmful compounds and/or reducing gas emissions at the source. In this context, the first objective of the research was to investigate the acute toxicity and the one after repeated exposure to toluene and its superior homologous solvents, which can be used as its substitution compounds, as well as its lower homologous on human bronchial epithelial cells using an air/liquid interface exposure device. The second objective was to assess the toxicity of gaseous effluents from the degradation of toluene by catalytic oxidation. For this purpose, BEAS-2B cells were exposed during 1 hour for 1, 3 or 5 days to benzene, toluene, xylene or mesitylene, and to the exhausts of catalytic oxidation of toluene. Toxic effects were evaluated through cytotoxicity, inflammatory response and gene expression of xenobiotic metabolism enzymes (XME). Exposure of BEAS-2B cells to toluene and its homologous compounds revealed the involvement of metabolic pathways specific to each compound. A significant increase in inflammatory marker response was also observed, with a higher concentration after cell exposure to benzene and to xylene compared to the other molecules. With regard to exposure to gaseous effluents from the catalytic oxidation of toluene, the late expression of genes involved in the metabolism of aromatic organic xenobiotics has made possible to highlight the presence of by-products, such as benzene or polycyclic aromatic hydrocarbons. In conclusion, the results obtained in this project show the interest of conducting repeated in vitro exposures to detect potential late effects, and the importance of toxicological validation of catalytic systems before scaling-up in industrial pilots
Jacob, Florence. "Génération contrôlée et détermination de l'impact toxicologique des aérosols organiques secondaires". Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS078.
Chronic exposure to atmospheric particles with a diameter less than 2.5 μm (PM2.5) at concentrations exceeding the levels recommended by the World Health Organization is responsible for the onset and/or exacerbation of respiratory, cardiovascular, neurological, and even cancer-related diseases. Regulatory threshold values have been defined regarding the ambient mass concentration of PM2.5, but these values do not take into account the impact of variations in the chemical composition of particles on induced biological effects. Special attention has been given in the literature to certain recognized harmful compounds such as metals and polycyclic aromatic hydrocarbons, some of which have been regulated. Nevertheless, other compounds are still poorly studied to date, even though they could also play an important role in particulate toxicity. This includes secondary organic aerosols (SOA), which constitute a major chemical fraction of PM2.5 and can represent up to 90% of their organic matter mass. They are formed through the reaction/oxidation/condensation of volatile organic compounds (VOCs) in the atmosphere. A rise in ambient SOA concentration is expected in the future due to the simultaneous increase in VOC precursor emissions and the oxidizing capacity of the atmosphere related to climate change. In this context, the present project first consisted in generating model SOA resulting from the oxidation of two VOCs that are widely present in the atmosphere, one of biogenic origin, limonene, and the other of anthropogenic origin, m-xylene. Limonene ozonolysis and m-xylene photooxidation were respectively carried out in a flow reactor and a simulation chamber. Two types of oxidations were tested for biogenic SOA synthesis: one with low ozone concentration and the other with high ozone concentration. The particulate phases were then characterized in terms of size (few hundred nm), mass, and chemical composition (hydroxyl, carbonyl, carboxylic acid functions, oligomers for limonene; nitrophenols, dimers for xylene). In a second step, the intrinsic oxidative potential (OP) of the generated biogenic and anthropogenic SOA was evaluated, as well as their toxicological impact in terms of oxidative stress and inflammatory effects on a model of immortalized human bronchial epithelial cells (BEAS-2B). The results obtained showed that among the biogenic SOA, those produced with low ozone concentration exhibit a more pronounced OP and antioxidant response. Furthermore, our results also indicate that, compared to these biogenic SOA, SOA resulting from m-xylene photooxidation have a higher OP and display greater cytotoxicity and activation of antioxidant defenses. In addition, oxidative damage to proteins and DNA was also detected in cells exposed to these SOA. Overall, the results from this project contribute to improving our knowledge on the chemical composition of SOA particulate phase and provide new insights into the mechanisms involved in their pulmonary toxicity
Mekki, Malik. "Caractérisation physico-chimique et évaluation toxicologique de fumées particulaires produites lors de tirs de petit calibre et de fumigènes : étude comparative". Thesis, Normandie, 2017. http://www.theses.fr/2017NORMR140/document.
Air pollution, and particulary anthropogenic particulate matter, is one of the most important risk factors involved in the high rate of morbidity and mortality related to respiratory and cardiovascular diseases. In pyrotechnic field, be it professional, civil or military activities, smokes constitue an important particle producer playing a major role in particulate matter emmergence and thereby exposing users to the various emitted aerosols.The main purpose of this exploratory study was to provide knowledge on the physicochemical characteristics of particles emitted during pyrotechnic activities, more specifically particles from gunfire and smokes, and to assess their pulmonary toxicity in vitro.On the first hand, the physicochemical characterization demonstrates that firing particles had a rather coarse granulometry (3 to 7.5 μm) and were mainly composed of metallic elemets, despite smoke particles belong to the category of fine particles (< 0,95 μm) and are predominantly composed of different organic molecules according to the smoke type.On the other hand, in order to assess the pulmonary toxicity of particles, we exposed human alveolar epithelial cells (A549) in vitro to particles coming from either gunfire and to two of the four different smokes (smoke 1 and 4). The results of this study showed that some of these particles (gunfire and smoke 1 particles) induced a mutagenic effects from organic extracts, as well as cytotoxicity. Moreover, particles of smoke 1 were also able to give rise to an oxidative stress (increased HO-1 mRNA expression) and to initiate an important inflammatory response characterized by pro-inflammatory cytokine upregulation (increase in IL-6 and IL-8 mRNA expression).The results of this comparative study demonstrated that particles from gunfire and smoke have different particle sizes and chemical composition. These physicochemical characteristics are responsible for different mutagenic and cytotoxic effects as well as alterations of the intrinsic oxidizing and inflammatory properties. This study also made it possible to understand the different methods of toxicological evaluation of smoke particles
Chapuis, Yannick. "Oxydation photocatalytique des composés organiques volatils". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0020/MQ57398.pdf.
Roussé, Davy. "Chimie multiphasique des composés organiques volatils". Lyon 1, 2005. http://www.theses.fr/2005LYO10161.
Stoian, Alina. "Modélisation et simulation de l'atmosphère d'une enceinte membranaire pour des tests de toxicité". Thesis, Montpellier 2, 2012. http://www.theses.fr/2012MON20026.
A major problem during in vitro evaluation of the toxicity of volatile organic compounds (VOC) is the lack of knowledge of the evolution of the concentration of such compounds during the course of experimental studies with living systems. This work presents the design of a novel experimental device for the study of cell culture exposure to VOCs. The device is made of two compartments separated by a porous hydrophobic membrane and allows relatively long durations of handling without restricting cellular breathing. A theoretical modeling which couples mass and moment conservation between the different phases inside the device with the breathing kinetics of hybridoma cells (ATCC CRL-1606) was developed. The model allows predicting the evolution of the concentration of the VOCs, the oxygen and the carbon dioxide inside the device. The simulations of the mass transfer of the VOCs simulated presented a good agreement with experiments and showed that the type of membrane and its diameter, the VOCs partition coefficient and the height of the liquid phase have a significant influence on the evolution of their concentration in the liquid phase. Nevertheless, the availability of oxygen for the cells depends mainly on the initial cellular density, the specific kinetics of consumption of this gas and on the height of the liquid phase, whereas the parameters related to membrane have an influence on the control of the pH
Ricquebourg, Emilie. "Etude de la réactivité et de la toxicité des particules de méthoxyphénols : analyse de leur action in vivo chez le rat en atmosphère contrôlée sur la fonction cardiaque et les paramètres du stress oxydant". Electronic Thesis or Diss., Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4711.
In general, inhalation of particles is at the origin of inflammatory and oxidative reactions who are responsible of the degradation of biological cellular constituents, and could have a strong cardiovascular impact. The wood combustion is a major source of semivolatile organic compounds such as the methoxyphenols (MPs) including coniferyl aldehyde (CA), syringaldehyde (SR), or acetosyringone (AS). The MPs are however few studies into literature while toxicity of other compounds also from biomass combustion, as carbon monoxide, soot and polycyclic aromatic hydrocarbon are intensively studies.This work has shown by GC/MS that aging in simulated atmosphere (ozone + light rays) degraded CA in secondary products less cytotoxic, studies on fribroblastes culture but keep the atmospherical level of SR and AS which have a toxicity proved.A device of MPs particle production original by atomization, with a check system (height, composition, weight) and exposition flow continuous (Ø~50 nm, N~7E4 particles/cm3, m~5 µg/m3) adapted to little animals, was developed and validated, allowed the first study in vivo with these molecules. Between 1 and 3 month of exposition to rat Wistar, show modified antioxidant defences and cardiac modification (ischaemia/reperfusion) principally with AS, then CA and less SR. The adaptatives processes (remodeling) are demonstrated after 5 month of exposition.Furthermore, it is showed in vitro on lung adenocacinum cell lines (A549), CA induced a monolayer destructuration and apoptosis (caspase 3) but no effect proinflammatory (IL8, Cox-2 and iNOS).To conclude, this work contributes to study the impact of MPs in vitro and in vivo
Libri sul tema "Composés organiques volatils – toxicité":
1959-, Albalak Ramon J., a cura di. Polymer devolatilization. New York: M. Dekker, 1996.
Conseil canadien des ministres de l'environnement. Normes nationales sur la teneur en composés organiques volatils des revêtements commerciaux et industriels canadiens: Finition d'automobiles. Winnipeg, Man: Conseil canadien des ministres de l'environnement, 1998.
Conseil canadien des ministres de l'environnement. Recommandation de normes et directives pour la réduction des émissions de COV provenant des opérations canadiennes de revêtements de maintenance industrielle. Winnipeg, Man: Conseil canadien des ministres de l'environnement, 2002.
Conseil canadien des ministres de l'environnement. Recommandation de normes et directives pour la réduction des émissions de COV provenant des opérations canadiennes de revêtements de pièces pour véhicules automobiles. Winnipeg, Man: Conseil canadien des ministres de l'environnement, 2002.
Canada. Commercial Chemicals Evaluation Branch., Canada Environment Canada e Cantox Environmental Inc, a cura di. A plan to reduce volatile organic compound emissions from consumer products in Canada (excluding windshield washer fluid and surface coatings): Final report. Hull, Quebec: Environment Canada, 2000.
Conseil canadien des ministres de l'environnement. Normes et directives nationales sur la réduction des composés organiques volatils provenant de l'application de revêtements commerciaux et industriels canadiens: Finition d'automobiles. Winnipeg, Man: Conseil canadien des ministres de l'environnement, 1998.
Hewitt, Alan D. Storage and preservation of soil samples for volatile compound analysis. Hanover, N.H: U.S. Army Cold Regions Research and Engineering Laboratory, 1999.
Carter, Anne-Marie. Tracking benzene and volatile organic compounds in the ambient air in Montreal's East End, 1989-2004 = Évolution du benzène et des composés organiques volatils dans l'air ambiant de l'est de Montréal, 1989-2004. Ottawa, Ont: Environment Canada = Environnement Canada, 2006.
Canadian Council of Ministers of the Environment. Recommended CCME standards and guidelines for the reduction of VOC emissions from Canadian industrial maintenance coatings. Winnipeg: Canadian Council of Ministers of the Environment, 2002.
E, Hester R., Harrison Roy M. 1948- e Royal Society of Chemistry (Great Britain), a cura di. Volatile organic compounds in the atmosphere. Cambridge: Royal Society of Chemistry, 1995.
Atti di convegni sul tema "Composés organiques volatils – toxicité":
Coudert, J. F. "Mesure de l’exposition aux Composés Organiques Volatils en milieu industriel". In 16th International Congress of Metrology. Les Ulis, France: EDP Sciences, 2013. http://dx.doi.org/10.1051/metrology/201310011.