Tesi sul tema "Cognitive"
Cita una fonte nei formati APA, MLA, Chicago, Harvard e in molti altri stili
Vedi i top-50 saggi (tesi di laurea o di dottorato) per l'attività di ricerca sul tema "Cognitive".
Accanto a ogni fonte nell'elenco di riferimenti c'è un pulsante "Aggiungi alla bibliografia". Premilo e genereremo automaticamente la citazione bibliografica dell'opera scelta nello stile citazionale di cui hai bisogno: APA, MLA, Harvard, Chicago, Vancouver ecc.
Puoi anche scaricare il testo completo della pubblicazione scientifica nel formato .pdf e leggere online l'abstract (il sommario) dell'opera se è presente nei metadati.
Vedi le tesi di molte aree scientifiche e compila una bibliografia corretta.
Blumen, Sheyla. "The development of cognitive abilities following the new outcomes of psychological theories". Pontificia Universidad Católica del Perú, 1997. http://repositorio.pucp.edu.pe/index/handle/123456789/101522.
Testo completoSe presentan los modelos más representativos del desarrollo cognitivo según los avances en las teorías psicológicas. Luego se realiza un breve análisis de los modelos en función a seis factores relacionados con diferentes áreas de la psicología y las ciencias sociales (importancia de cada etapa, procesos, conocimiento, diferencias individuales, contexto y limitaciones en el desarrollo cognitivo). Finalmente se presenta una propuesta de integración de los modelos actuales del desarrollo cognitivo desarrollado por Sincoff y Sternberg (1989)
Farias, Alyne Matos Napoleão. "Estimulação cognitiva em idosos sedentários com transtorno cognitivo leve". Universidade Católica de Brasília, 2018. https://bdtd.ucb.br:8443/jspui/handle/tede/2459.
Testo completoApproved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2018-09-14T21:40:19Z (GMT) No. of bitstreams: 1 AlyneMatosNapoleaoFariasDissertacao2018.pdf: 1451305 bytes, checksum: 3527c8590821219daf2aad10bf27a157 (MD5)
Made available in DSpace on 2018-09-14T21:40:19Z (GMT). No. of bitstreams: 1 AlyneMatosNapoleaoFariasDissertacao2018.pdf: 1451305 bytes, checksum: 3527c8590821219daf2aad10bf27a157 (MD5) Previous issue date: 2018-07-05
In Brazil the number of elderly people is increasing and this transformation in the age structure is taking place without an improvement of the living conditions. With increased life expectancy there is a greater probability of chronic and degenerative diseases, such as Mild Cognitive Disorder (MCD). The use of cognitive stimuli through cognitive stimulation therapies (CST) causes them to regress and / or interfere with advancement. The objective was to analyze changes in cognitive profile, with emphasis on memory, before and after the execution of cognitive stimulation workshops, as well as to identify socioeconomic characteristics of sedentary elderly people who attend the Mixed Health Unit of Taguatinga, Federal District (UMS-DF). It was a descriptive experimental quantitative study, with elderly (≥60 years), diagnosed with MCD. The composite sample of 9 elderly of the OEC in the experimental group (G1) and 10 elderly did not undergo intervention in the control group (G2). The data collection was done by structured interview, application in the first and last meeting of the mini mental state examination, verbal fluency, clock, memory of figures and list of words. The CST offered to the G1, stimulation techniques were used, for one hour, weekly, in 10 meetings. In G2, daily life activities were reported for the same period, without cognitive stimulation. The descriptive data were evaluated by means of descriptive measures: means, standard deviations, median, absolute and relative frequency, with p <= 0,05. The chi-square test and t-test were applied using the SPSS 20.0 program and the R. software. Results showed mean age of 75 ± years, 84.2% female, 89.5% retired and 89.5% widowed. 17 elderly (89.5%) reported better memory a year ago. After CST, 8 (88.9%) elderly of the G1 considered their current memory as good. Although the G1 elderly had higher scores in all tests after the CST, the difference between the tests was not significant (p = 1.0). No significant differences were found in the Miniexame of the Mental State (p = 0.436). The test of the clock design evidenced the low level of schooling. G1 (p> 1) and G2 (p = 0.621), the tests were not statistically significant, affirming no or almost no change in the cognitive profile. In the tests of verbal fluency (p = 0.367), word memory and figures (p = 0.351), G2 showed no recovery in recall, despite reporting an increase in group sociability. It was concluded that although the CST do not have significant results, they have a visible effect on social integration, exchange of experiences and personal empowerment. This method can help nursing to design more effective methods and implementations for the treatment and rehabilitation of not only elderly people with MCD, but with different cognitive conditions. Perhaps longer-term studies can improve such outcomes and encompass the positive aspects of physical activity in the cognitive area.
No Brasil, é crescente o número de idosos e essa transformação na estrutura etária dá-se sem que haja um melhoramento das condições de vida. Com o aumento da expectativa de vida, há maior probabilidade de doenças crônicas e degenerativas, como o Transtorno Cognitivo Leve (TCL). A utilização de estímulos cognitivos, através de oficinas de estimulação cognitiva (OEC), causa seu retrocesso e/ou interfere no avanço. O objetivo foi analisar modificações no perfil cognitivo, com ênfase na memória, antes e após a execução das oficinas de estimulação cognitiva, assim como identificar características socioeconômicas de idosos sedentários que frequentam a Unidade Mista de Saúde de Taguatinga do Distrito Federal (UMST-DF). Foi um estudo quantitativo experimental descritivo, com idosos (≥60 anos), diagnosticados com TCL. A amostra composta de nove idosos das OEC no grupo experimental (G1) e dez idosos que não sofreram intervenção no grupo controle (G2). A coleta de dados foi feita por entrevista estruturada, aplicação no primeiro e último encontro do Miniexame do Estado Mental (MEEM), fluência verbal, relógio, memória de figuras e lista de palavras. As OEC oferecidas ao G1 utilizaram técnicas de estimulação, por uma hora, semanalmente, em dez encontros. No G2, foram feitos relatos das atividades da vida diária, pelo mesmo período, sem estimulação cognitiva. Os dados descritivos foram avaliados pelas medidas descritivas: médias, desvios padrões, mediana, frequência absoluta e relativa, com p<=0,05. Foram aplicados teste de qui-quadrado e teste t pelo programa SPSS 20.0 e software R. Resultados mostraram idade média de 75± anos, 84,2% feminino, 89,5% aposentados e 89,5% viúvos. 17 idosos (89,5%) relataram memória melhor há um ano. Após as OEC, oito (88,9%) idosos do G1 consideraram sua memória atual como boa. Apesar dos idosos do G1 terem pontuações maiores em todos os testes após as OEC, a diferença entre os testes não foram significativas (p= 1,0). No MEEM não surgiu diferença significativa (p=0,436). O teste do desenho do relógio evidenciou o baixo nível de escolaridade: G1 (p>1) e G2 (p= 0,621); os testes não foram significativos, afirmando nenhuma ou quase nenhuma mudança no perfil cognitivo. Nos testes de fluência verbal (p=0,367), de memória de palavras e o de figuras (p=,0,351), o G2 não mostrou recuperação na evocação da memória, apesar de relatar aumento na sociabilidade em grupo. Concluiu-se que, apesar das OEC não terem resultados estatisticamente significativos, possuem efeito visível na integração social, troca de experiências e empoderamento pessoal. Esse método pode auxiliar a enfermagem a traçar métodos e implementações mais eficazes para o tratamento e reabilitação, não só pessoas idosas com TCL, mas com diversas condições cognitivas. Talvez estudos com prazos maiores possam aprimorar tais resultados e abranger os aspectos positivos das atividades físicas na área cognitiva.
Teixeira, Stefânia Martins. "Desempenho cognitivo e transtornos de humor em adultos jovens: contribuições das esclas Weschler de Inteligência". Universidade Catolica de Pelotas, 2013. http://tede.ucpel.edu.br:8080/jspui/handle/tede/355.
Testo completoObjective: The aim of this study is to correlate the cognitive impairment with a severity symptoms in young adults with mood disorder, as well, to analyze the difference between the groups with diagnostic and healthy controls population- based. Methods: Cross-sectional study with young adults of 21 to 30 years old who participated from a population-base sample. The impairment cognitive were assessed using Wechsler Scale of Intelligence (WAIS-III). Depressive symptoms were assessed using the Beck Depression Inventory (BDI-II), while the manic symptoms were assessed using the Young Mania Rating Scale (YMRS). Results: The total sample consisted of 83 participants which were distributed in: 13 with bipolar disorder, 34 with depressive symptoms and 36 healthy controls. The cognitive performance was not associated with severity of mood symptoms. In this sample of young adults, it was also found cognitive impairment between subjects with bipolar disorder and major depression when compared the controls. Conclusion: The results suggest that the young adults with bipolar disorder or depression don t come up with cognitive impairment when measured at WAIS III
Objetivo: Correlacionar o desempenho cognitivo com a severidade de sintomas maníacos e depressivos em adultos jovens com transtornos de humor, bem como, verificar a diferença entre os grupos com diagnóstico e controles populacionais. Método: Estudo transversal aninhado a um estudo de base populacional com jovens de 21 a 30 anos. Para avaliação do desempenho cognitivo foi utilizado a Escala Wechsler de Inteligência para Adultos (WAIS-III). Os sintomas depressivos foram avaliados através da Beck Depression Inventory (BDI-II), enquanto os sintomas maníacos por meio da Young Mania Rating Scale (YMRS). Resultados: A amostra total contou com 83 participantes, os quais estavam distribuídos em: 13 com transtorno bipolar, 34 com sintomas depressivos e 36 controles saudáveis. O desempenho cognitivo não foi associado à severidade dos sintomas de humor. Nesta amostra de adultos jovens, também não foi encontrado prejuízo cognitivo entre os indivíduos com diagnóstico de transtorno bipolar e depressão quando comparados aos controles. Conclusão: Os achados sugerem que adultos jovens com transtorno bipolar ou depressão não apresentam comprometimento cognitivo quando mensurado pelo WAIS III
Hogervorst, Eva. "Age-related cognitive decline and cognition enhancers". Maastricht : Maastricht : Neuropsych Publishers ; University Library, Maastricht University [Host], 1998. http://arno.unimaas.nl/show.cgi?fid=6058.
Testo completoCattinelli, I. "INVESTIGATIONS ON COGNITIVE COMPUTATION AND COMPUTATIONAL COGNITION". Doctoral thesis, Università degli Studi di Milano, 2011. http://hdl.handle.net/2434/155482.
Testo completoDutra, Elaine Cristina Pereira. "Tradução e Cognição: Interfaces". Universidade Federal do Espírito Santo, 2009. http://repositorio.ufes.br/handle/10/3704.
Testo completoA presente pesquisa procura elencar os estudos da tradução relacionando-os aos campos da psicologia, antropologia, biologia, linguística cognitiva e literatura. Nosso objetivo é o de demonstrar a relação que existe entre a teoria do protótipo e a tradução. Ao início, explicitamos as correntes teóricas que versam sobre aquisição e aprendizagem de primeira e segunda línguas, bilinguismo, formação do tradutor, tipos de tradução, competências linguísticas relacionadas à tradução. O texto aborda e relaciona os processos psicológicos cognitivos ao ato de traduzir: introspecção, percepção, abstração, memória, pensamento, conceptualização. Apresentamos os papéis do efeito prototípico e da equivalência tradutiva, relacionando-os e conceituando-os, concluindo que há níveis de equivalência mais ou menos aceitáveis (efeito de gradiência/ prototípico) segundo o julgamento do tradutor e que há traços invariáveis (protótipos) que são percebidos e perpetuados por leitores e tradutores. Para corroborar a hipótese, analisamos textos traduzidos, buscando o efeito e a presença do protótipo e concluímos que este é o de maior ocorrência, o que reflete a rede de construções conceituais que norteia os processos de pensamento e de memória do tradutor.
This research attempts to relate translation studies to psychology, anthropology, biology, cognitive linguistics and literature. Our objective is to demonstrate the relationship between the theory of prototype and translation. To do so, we discuss the current theoretical focus on the acquisition and learning of the first and second languages, bilingualism, the training of the translator, types of translation, and the linguistic competence related to translation. We also present the psychological cognitive processes in the act of translate: introspection, perception, abstraction, memory, thought, conceptualizing. We present the role of the prototype effect and of equivalence in translation, relating them and evaluating them, concluding that there are levels of equivalence more or less acceptable (gradient effect / prototypical) according to the judgment of the translator and that there are invariable lines (prototypes) that are perceived and perpetuated by readers and translators. So as to corroborate with the hypothesis, we analyze translated texts, seeking the effect and the presence of the prototype and we conclude that the basic level is of the highest occurrence, and reflects the net of constructions that guide the translator’s thought and memory.
Pinkston, Sophie Wardle. "Insomnia and Cognitive Performance: A Systematic Review and Meta-Analysis". Thesis, University of North Texas, 2019. https://digital.library.unt.edu/ark:/67531/metadc1505168/.
Testo completoFox, Nathan Josephe. "Cognitive architecture and the function of human cognition". Thesis, University of British Columbia, 2010. http://hdl.handle.net/2429/25027.
Testo completoGraduate
Greenlee, Christopher Alan. "Situated Cognition, Dynamicism, and Explanation in Cognitive Science". Thesis, Virginia Tech, 1998. http://hdl.handle.net/10919/46501.
Testo completoMaster of Arts
Holder, Barbara E. "Cognition in flight : understanding cockpits as cognitive systems /". Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1999. http://wwwlib.umi.com/cr/ucsd/fullcit?p9945784.
Testo completoSchultheis, Holger. "Computational cognitive modeling of control in spatial cognition". Lengerich Berlin Bremen Miami, Fla. Riga Viernheim Wien Zagreb Pabst Science Publ, 2009. http://d-nb.info/998029661/04.
Testo completoGurian, Maria Beatriz Ferreira. "Rastreamento cognitivo por instrumento baseado no MEEM em idosos não institucionalizados residentes em Batatais-SP". Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/17/17139/tde-24112006-151338/.
Testo completoThe cognitive impairment in the old has its effects on their lives, families and relationships with society. A widely used instrument of cognitive assessment is the MMSE- Mini Mental State - that is a screening test whose aim is to select people with probable cognitive deficiency. A significant sample of the population of 394 old people from Batatais - SP, was evaluated through a home survey considering the socioeconomic and health conditions and a screening of depressive symptoms and cognitive performance was done through an instrument based on MMSE. The great majority of people who were interviewed were female (66%) and 75.4% of the old belonged to an age group from 60 to 74 years old, being considered \"younger old\". Regarding scholarship, most of them had attended primary school (62.2%). Considering the illiterate 77.1% were women and 22.9% were men. Concerning marital status a huge difference between the proportion of widows (80.2%) and widowers (19.8%) was found. With reference to familiar income 43.7% of the population earned less than 2.5 minimum wages. To evaluate the cognitive performance a cut off ? 23 for MMSE was used. It was observed that 81.7% of the old were above and 18.3% were under this point. The old who achieved the highest scores had factors such as age (60-69 years old), better scholarship level, reading habits, a good social relationship (mainly with relatives), no high blood pressure, no diabetes, no urinary incontinence, no cataract and absence of depressive symptoms.
Schmitt, Wolfram. "The Cognitive View in Cognitive Science". Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-76547.
Testo completoSchwarz, Monika. "Kognitive Semantiktheorie und neuropsychologische Realität : repräsentationale und prozedurale Aspekte der semantischen Kompetenz /". Tübingen : M. Niemeyer, 1992. http://catalogue.bnf.fr/ark:/12148/cb35599434c.
Testo completoHickox, Sherrie Danene. "Life Stress and Adjustment: Effects of Cognitive Content and Cognitive Organization". Thesis, North Texas State University, 1985. https://digital.library.unt.edu/ark:/67531/metadc331234/.
Testo completoParker, Deborah A. (Deborah Ann). "Children's Cognitive and Moral Reasoning: Expressive Versus Receptive Cognitive Skills". Thesis, North Texas State University, 1986. https://digital.library.unt.edu/ark:/67531/metadc331176/.
Testo completoGuignard, Jean-Baptiste. "La linguistique cognitive : épistémologie d'un modèle émergent". Bordeaux 3, 2008. http://www.theses.fr/2008BOR30085.
Testo completoA product of research initiated in the mid 1970’s on the West Coast of America, cognitive linguistics aims to account for linguistic facts by an appeal to universal cognitive operations. This postulate provides the unifying focus for a diverse and productive research field and for a number of loose conceptual models which it is the purpose of this study to unify by means of a semiotic triad. Beyond the current plurality of its objects, and because its central claim is that language is a means of gaining insight into the faculty of knowledge, cognitive linguistics oscillates between, and attempts to unite, the requirements of linguistics and cognitive science. As such, it ascribes a nodal function to the theories of categorization. For the mind that subtends language, a ‘unity’ (symbolic or ‘objective’) is primarily a unity of categorial perception. The present study provides a critical examination of the principal theoretical articulations of this multidisciplinary programme. Because the challenge for cognitive linguistics is to meet the specific and distinct research demands of language, mind and categorial phenomena, the primary focus of this study is an inquiry into the foundations of these three major axes of the general theory. Naturally, a project such as this is only conceivable in view of the current state of cognitive science generally, and of the historical contiguities that characterize the specificities of this intellectual programme
Bolívar, Díaz Nicolás. "Medium access control messaging scheme for cognitive radio networks". Doctoral thesis, Universitat de Girona, 2012. http://hdl.handle.net/10803/84098.
Testo completoCruz, Sylvio Benedicto. "A teoria da modificabilidade cognitiva estrutural de Feuerstein. Aplicação do Programa de Enriquecimento Instrumental (PEI) em estudantes da 3ª série de escolas do ensino médio". Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/48/48134/tde-10122007-160413/.
Testo completoIn the recent past, both society and labour market are demanding from citizens a performance far different from those accept until then. The major lacks of workers may concern, among others, to the development of specific personal competences and to the improve of the cognitive process. Schools, responsible for the preparation for life in society - including the life in the labour market - don\'t usually take intentional educational actions aiming the improve of the cognitive development of their students. The focus of the present study is mainly on analyzing the possibility of Schools to make an intentional effort to develop student\'s cognitive habilities, future workers, using a preexisting program created and structured for this meaning by Reuven Feuerstein. In the late 40\'s, Feurstein took the task of teaching hundreds of children and teenagers, war orphan children, to become autonomous and productive citizens. Facing the real need of improving their cognitive habilities and rescuing their citizenship, Feuerstein came up - using his own wide world perception, personal beliefs and experience - with two theories: Structural Cognitive Modifiability (SCM) and Mediated Learning Experience (MLE) and three interrelated systems, or an evaluation system: Learning Potential Assesment Device (LPAD), an interventional system: Feuerstein Instrumental Enrichment (FIE) and a maintenance system: Shaping Modifying Environments (ME). The aim of this paper is to evaluate the effect of the first level of the Feuerstein Instrumental Enrichment (FIE I) on 3rd grade public or private High School student\'s cognitive development. Summing up, there were 96 students involved in this project (54 boys and 42 girls) from two different High Schools: one private and one public. Sixty seven of these students were placed on experimental groups that were submitted to FIE I and the other 29 kids took part on control groups, staying away from the program application. All the students participated on an initial evaluation, facing six instruments, some of then allowing a dynamic evaluation. From the instrument result analysys, needs were raised and intervention procedures were established. The students\'s experimental group was submitted to the first level of the Feuerstein Instrumental Enrichment (FIE I). During its application, the students had an intermediary evaluation, made by the application of the evaluation instrument and by a questionnaire to measure the student\'s level of perception about the (FIE I). Finally, all the participants were submitted to a final evaluation. The results were analyzed in a descriptive statistical way. The U or Mann-Whitney tests and the t for Student test were used to indicate probable similarities and differences among the student\'s groups performances. From its discussion were put together propositions to justify the following conclusions: The student\'s experimental group structural cognitive modifiability was raised. The cognitive development shown by the student\'s experimental group was higher than the cognitive performance shown by the student\'s control group.
Li, Calzi Valérie. "Effets des composants de la mémoire de travail sur la production écrite de textes". Aix-Marseille 1, 2000. http://www.theses.fr/2000AIX10067.
Testo completoFortman, James Alexander. "Computer-Based Cognitive Training for Age-Related Cognitive Decline and Mild Cognitive Impairment". Antioch University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1353454752.
Testo completoBornard, Jean-Charles. "Développement d'un modèle du conducteur automobile : De la modélisation cognitive à la simulation numérique". Phd thesis, Université Sciences et Technologies - Bordeaux I, 2012. http://tel.archives-ouvertes.fr/tel-00779706.
Testo completoBarreto, Dulcilene Rodrigues da Silva. "A Conceitualização de Educação à Luz da Teoria dos Modelos Cognitivos Idealizados: Percorrendo Veredas Entre Mente e linguagem dos Alunos da Educação Básica". http://www.teses.ufc.br, 2011. http://www.repositorio.ufc.br/handle/riufc/3612.
Testo completoSubmitted by nazareno mesquita (nazagon36@yahoo.com.br) on 2012-07-04T16:49:58Z No. of bitstreams: 1 2011_diss_DBARRETO.PDF: 24801017 bytes, checksum: 38335b2b2bc18d29fe8275fb6864bcd8 (MD5)
Approved for entry into archive by Maria Josineide Góis(josineide@ufc.br) on 2012-08-03T16:34:47Z (GMT) No. of bitstreams: 1 2011_diss_DBARRETO.PDF: 24801017 bytes, checksum: 38335b2b2bc18d29fe8275fb6864bcd8 (MD5)
Made available in DSpace on 2012-08-03T16:34:47Z (GMT). No. of bitstreams: 1 2011_diss_DBARRETO.PDF: 24801017 bytes, checksum: 38335b2b2bc18d29fe8275fb6864bcd8 (MD5) Previous issue date: 2011
This research aimed to analyze, through the structured principals of Idealized Cognitive Models Theory (LAKOFF, 1987), embodied, socio cognitive situated meanings attributed to the concept of EDUCATION by thirty-three final year high school students of a government school in Fortaleza, Ceara, Brazil, who participated of the research as unpaid volunteers. In order to achieve the mentioned aim, it was analyzed the responses provided by the students in answering two tasks – a questionnaire and a writing task aimed at eliciting data which allowed to explore the category prototypical nature and its metaphoric and metonymic extensions. The methodological approach follows the principals proposed by lakofian Cognitive Semantics which posits that people concepts are not arbitrary but emerge from the nature of their bodies in dynamic interactions with the ecological and social cultural world. The qualitative data analysis was supported by Lakoff’s (1987) Idealized Cognitive Models Theory (ICMT) and Lakoff and Johnson’s (1980/[2002]) Conceptual Metaphor Theory (CMT). The texts produced by the participants made possible the analysis of the ORIGIN – TRAJECTORY – TARGET and CONTAINER image schemas in the structuring of the EDUCATION concept, the most salient proposition models (frame and scripts) to represent the school routine and the EDUCATION metaphors. The data gathered were organized in table and graphs in order to allow for comparisons between semantically close expressions and the distribution of the analyses about the EDUCATION concept structuring cognitive models. Such organization has also facilitated the metaphoric projections and their entailments. The most relevant metaphors were EDUCATION IS AN ACQUIRED, VALUABLE ASSET and EDUCATION IS A JOURNEY. The results obtained have also allowed to propose a radial category for the concept of EDUCATION as it emerges from embodied social culturally beliefs and values shared by the participants.
Esta pesquisa objetivou analisar, por meio dos princípios estruturadores dos Modelos Cognitivos Idealizados(LAKOFF, 1987), os significados sociocognitivamente situados atribuídos ao conceito de EDUCAÇÃO por trinta e três alunos concludentes do Ensino Médio de uma escola pública em Fortaleza, Ceará, Brasil,que participaram da pesquisa como voluntários não remunerados. Para se atingir o objetivo proposto, foram analisadas as respostas fornecidas pelos alunos em duas tarefas - um questionário e uma atividade escrita destinadas a obter dados que permitiram explorar a natureza prototípica da categoria e suas extensões metafóricas e metonímicas. A abordagem metodológica segue os princípios propostos pela Semântica Cognitiva de Lakoff que postula que os conceitos das pessoas não são arbitrários, mas emergem da natureza de seus corpos em interações dinâmicas com o mundo ecológico e sociocultural.A análise de dados qualitativos apoiou-sena Teoria dos Modelos Cognitivos Idealizados (TMCI), de George Lakoff (1987) e na Teoria da Metáfora Conceitual (CMT), de Lakoff e Johnson (1980/[2002]). Os textos produzidos pelos participantes tornaram possível a análise os modelos de esquemas de imagem ORIGEM-PERCURSO-META E CONTEINER na estruturação do conceito EDUCAÇÃO, os modelos proposicionais frames e scripts que se sobressaíram para representar o cotidiano escolar e as metáforas sobre EDUCAÇÃO.Os dados colhidos foram organizados em tabelas e gráficos de modo a permitir o estabelecimento de comparações entre as expressões semanticamente afins coletadas nos questionários e a distribuição das análises sobre os modelos cognitivos estruturantes. Essa organização também facilitou as análises de projeções metafóricas e seus acarretamentos. As mais relevantes metáforas foram EDUCAÇÃO É BEM ADQUIRIDO, VALIOSO e EDUCAÇÃO É VIAGEM.Os resultados obtidos também permitiram propor uma categoria radial para o conceito de EDUCAÇÃO no modo como ele emerge das crenças social e culturalmente consagradas e dos valores compartilhados pelos participantes.
Hilger, Anne. "Cognitive and non-cognitive skills in developing countries". Thesis, Paris Sciences et Lettres (ComUE), 2018. http://www.theses.fr/2018PSLEH077.
Testo completoThis dissertation examines the role that cognitive and non-cognitive skills play in developing countries along three axes: measurement of these skills, wage returns to them, and as determinants of levels of trust. The first chapter uses panel data from two cohorts of a skills training program in Mozambique to contrast two types of skill measurement: self-assessments and observational exercises. The chapter shows that self-assessments capture underlying traits, while observational exercises are better suited for program evaluations. The second chapter is based on a novel matched employer-employee data set representing the formal sector in Bangladesh and provides evidence of both the relative importance of cognitive and non-cognitive skills in this part of the labor market and the interplay between skills and hiring channels in determining wages. Results demonstrate positive returns to non-cognitive skills, varying by hiring channel. This chapter also offers suggestive evidence that employers might use hiring channels differently, depending on which skills they deem important. The third chapter makes use of the demonetization policy of November 2016 in India and a newly collected data set to causally identify the determinants of trust in a rural setting, controlling for a variety of individual characteristics, such as non-cognitive skills and cognitive ability, that could influence network formation and trust. We find that social interactions determine trust, though this result holds only among men and varies along the lines of caste membership
Jin, Alvin B. "Perseverative Cognition, Cognitive Load, and Distraction in Recovery from Stress". Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3170.
Testo completoAkagi, Mikio Shaun Mikuriya. "Cognition in practice| Conceptual development and disagreement in cognitive science". Thesis, University of Pittsburgh, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10183682.
Testo completoCognitive science has been beset for thirty years by foundational disputes about the nature and extension of cognition—e.g. whether cognition is necessarily representational, whether cognitive processes extend outside the brain or body, and whether plants or microbes have them. Whereas previous philosophical work aimed to settle these disputes, I aim to understand what conception of cognition scientists could share given that they disagree so fundamentally. To this end, I develop a number of variations on traditional conceptual explication, and defend a novel explication of cognition called the sensitive management hypothesis.
Since expert judgments about the extension of “cognition” vary so much, I argue that there is value in explication that accurately models the variance in judgments rather than taking sides or treating that variance as noise. I say of explications that accomplish this that they are ecumenically extensionally adequate. Thus, rather than adjudicating whether, say, plants can have cognitive processes like humans, an ecumenically adequate explication should classify these cases differently: human cognitive processes as paradigmatically cognitive, and plant processes as controversially cognitive.
I achieve ecumenical adequacy by articulating conceptual explications with parameters, or terms that can be assigned a number of distinct interpretations based on the background commitments of participants in a discourse. For example, an explication might require that cognition cause “behavior,” and imply that plant processes are cognitive or not depending on whether anything plants do can be considered “behavior.” Parameterization provides a unified treatment of embattled concepts by isolating topics of disagreement in a small number of parameters.
I incorporate these innovations into an account on which cognition is the “sensitive management of organismal behavior.” The sensitive management hypothesis is ecumenically extensionally adequate, accurately classifying a broad variety of cases as paradigmatically or controversially cognitive phenomena. I also describe an extremely permissive version of the sensitive management hypothesis, arguing that it has the potential to explain several features of cognitive scientific discourse, including various facts about the way cognitive scientists ascribe representations to cognitive systems.
Makány, Tamás. "Strategies of human spatial cognition : cognitive and behavioural trade-offs". Thesis, University of Southampton, 2009. https://eprints.soton.ac.uk/66157/.
Testo completoMortu, Ancuta-Maria. "De la cognition esthétique à l'esthétique cognitive : une étude généalogique". Paris, EHESS, 2015. http://www.theses.fr/2015EHES0138.
Testo completoThe purpose of this thesis is to draw a genealogy of cognition as a constitutive part of aesthetic experience, considering that this field has been developing ever since the birth of the discipline of aesthetics itself. More specifically, we argue that aesthetic experience, as any ordinary experience, is an information-processing activity whose dynamics car be accounted for by using the conceptual tools of cognitive psychology. The main questions that we ask throughout this work, that also concern the philosophical aesthetics as well as the history of ideas, are the following : what are the informational processes involved in aesthetic experience ? In what respect did the concept of information modify the classical approaches to aesthetic experience ? In what way does it contribute to understanding the phenomenology of this particular type of experience ? In order to give an answer to these questions, we have organized this work into two parts : Part I deals with the archeology or the prehistory of cognition and its presence in aesthetic discourse, namely in the enlightenment period and at the birth of experimental psychology, while Part II comprises a close analysis of the architectural structure of informational aesthetic models that are being developed starting with the second half of the twentieth century. The genealogical approach that we favor allows us to emphasize the continuing relevance of questions related to invariants of mental reality engaged in aesthetic encounters
Sussams, Rebecca. "Stress and its impact on cognition in mild cognitive impairment". Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/422260/.
Testo completoMitola, Joseph. "Cognitive radio". Doctoral thesis, KTH, Teleinformatics, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2987.
Testo completoMenary, Richard Anthony. "Cognitive integration". Thesis, King's College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430041.
Testo completoPokalchuk, O. "Cognitive Wars". Thesis, Sumy State University, 2021. https://essuir.sumdu.edu.ua/handle/123456789/84755.
Testo completoThomas, Ryan William. "Cognitive Networks". Diss., Virginia Tech, 2007. http://hdl.handle.net/10919/28319.
Testo completoPh. D.
CONTE, FEDERICA PAOLA. "Cognitive Reserve Potential: Assessing personal and situational determinants of lifetime cognitive trajectories". Doctoral thesis, Università degli Studi di Milano-Bicocca, 2021. http://hdl.handle.net/10281/325893.
Testo completoCognitive Reserve is a theoretical construct elaborated to explain discrepancies between brain integrity and cognitive functioning. Indeed, high interindividual variability has been observed in the relationship between neural damage and its clinical and functional manifestation. Cognitive Reserve explains this variability in terms of efficiency and flexibility of brain processes: greater adaptability in the execution of cognitive tasks grants a better response to brain damage or ageing. The development of Cognitive Reserve is influenced on the one hand by innate factors and on the other by experiences encountered throughout the lifespan: mainly education, work activity, and leisure activities. Because of this "cumulative" nature of Cognitive Reserve, in this dissertation, we emphasise the importance of investigating the factors that determine its development from a young age. Thus, we propose the concept of Cognitive Reserve Potential (CRP) to represent the set of functional resources available during adolescence, before educational and work experiences are concluded or even started. In the first work presented here, we use data from a longitudinal birth cohort study to examine the impact of youth cognitive functioning in a longitudinal perspective. Our analysis relies on latent growth curve models to investigate the association between earlier (11-70 years) and later (70-82 years) cognitive change. We thus show for the first time how trajectories of cognitive change between childhood and late adulthood significantly predict decline over 12 subsequent years. This finding sheds light on the nature of cognitive ageing and lends additional relevance to early life experiences, the impact of which may reverberate across the lifespan into later life. The second study aims to clarify the relationship between environmental and experiential factors and cognitive functioning in adolescence. In it, we analyse the complex system consisting of measures of crystallised intelligence, fluid intelligence, and indicators of several environmental dimensions, namely, socioeconomic status, home possessions, cultural capital, and reading habits. A network analysis shows that cultural capital and reading habits are associated with verbal abilities independently of socioeconomic status and possessions. Thus, this study confirms the importance of taking a more nuanced view than just socioeconomic status when considering environmental and experiential factors in relation to cognitive development. To address this need, in Study 3, we develop a questionnaire dedicated to the assessment of Cognitive Reserve Potential in adolescents, the CRPq. The instrument measures attitudes and habits pertaining to leisure activities, family environment, peer relations and eating habits. A principal component analysis, confirmed by a factor analysis performed on an independent sample, shows that the CRPq reliably measures 12 subscales while also providing a global CRP score. Thus, we could perform an initial exploration of associations between CRP and measures of intelligence, executive functioning, and socioeconomic factors, which was also presented and discussed in Study 3. Cognitive Reserve in youth is a complex phenomenon that has only recently begun to be studied. The present dissertation, therefore, represents an initial approach. In our concluding remarks, we reflect on the challenges encountered so far and on possible future perspectives.
Barreto, Dulcilene Rodrigues da Silva. "A conceitualizaÃÃo de educaÃÃo à luz da teoria dos modelos cognitivos idealizados: percorrendo veredas entre mente e linguagem dos alunos da educaÃÃo bÃsica". Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=6760.
Testo completoEsta pesquisa objetivou analisar, por meio dos princÃpios estruturadores dos Modelos Cognitivos Idealizados(LAKOFF, 1987), os significados sociocognitivamente situados atribuÃdos ao conceito de EDUCAÃÃO por trinta e trÃs alunos concludentes do Ensino MÃdio de uma escola pÃblica em Fortaleza, CearÃ, Brasil,que participaram da pesquisa como voluntÃrios nÃo remunerados. Para se atingir o objetivo proposto, foram analisadas as respostas fornecidas pelos alunos em duas tarefas - um questionÃrio e uma atividade escrita destinadas a obter dados que permitiram explorar a natureza prototÃpica da categoria e suas extensÃes metafÃricas e metonÃmicas. A abordagem metodolÃgica segue os princÃpios propostos pela SemÃntica Cognitiva de Lakoff que postula que os conceitos das pessoas nÃo sÃo arbitrÃrios, mas emergem da natureza de seus corpos em interaÃÃes dinÃmicas com o mundo ecolÃgico e sociocultural.A anÃlise de dados qualitativos apoiou-sena Teoria dos Modelos Cognitivos Idealizados (TMCI), de George Lakoff (1987) e na Teoria da MetÃfora Conceitual (CMT), de Lakoff e Johnson (1980/[2002]). Os textos produzidos pelos participantes tornaram possÃvel a anÃlise os modelos de esquemas de imagem ORIGEM-PERCURSO-META E CONTEINER na estruturaÃÃo do conceito EDUCAÃÃO, os modelos proposicionais frames e scripts que se sobressaÃram para representar o cotidiano escolar e as metÃforas sobre EDUCAÃÃO.Os dados colhidos foram organizados em tabelas e grÃficos de modo a permitir o estabelecimento de comparaÃÃes entre as expressÃes semanticamente afins coletadas nos questionÃrios e a distribuiÃÃo das anÃlises sobre os modelos cognitivos estruturantes. Essa organizaÃÃo tambÃm facilitou as anÃlises de projeÃÃes metafÃricas e seus acarretamentos. As mais relevantes metÃforas foram EDUCAÃÃO Ã BEM ADQUIRIDO, VALIOSO e EDUCAÃÃO Ã VIAGEM.Os resultados obtidos tambÃm permitiram propor uma categoria radial para o conceito de EDUCAÃÃO no modo como ele emerge das crenÃas social e culturalmente consagradas e dos valores compartilhados pelos participantes.
This research aimed to analyze, through the structured principals of Idealized Cognitive Models Theory (LAKOFF, 1987), embodied, socio cognitive situated meanings attributed to the concept of EDUCATION by thirty-three final year high school students of a government school in Fortaleza, Ceara, Brazil, who participated of the research as unpaid volunteers. In order to achieve the mentioned aim, it was analyzed the responses provided by the students in answering two tasks â a questionnaire and a writing task aimed at eliciting data which allowed to explore the category prototypical nature and its metaphoric and metonymic extensions. The methodological approach follows the principals proposed by lakofian Cognitive Semantics which posits that people concepts are not arbitrary but emerge from the nature of their bodies in dynamic interactions with the ecological and social cultural world. The qualitative data analysis was supported by Lakoffâs (1987) Idealized Cognitive Models Theory (ICMT) and Lakoff and Johnsonâs (1980/[2002]) Conceptual Metaphor Theory (CMT). The texts produced by the participants made possible the analysis of the ORIGIN â TRAJECTORY â TARGET and CONTAINER image schemas in the structuring of the EDUCATION concept, the most salient proposition models (frame and scripts) to represent the school routine and the EDUCATION metaphors. The data gathered were organized in table and graphs in order to allow for comparisons between semantically close expressions and the distribution of the analyses about the EDUCATION concept structuring cognitive models. Such organization has also facilitated the metaphoric projections and their entailments. The most relevant metaphors were EDUCATION IS AN ACQUIRED, VALUABLE ASSET and EDUCATION IS A JOURNEY. The results obtained have also allowed to propose a radial category for the concept of EDUCATION as it emerges from embodied social culturally beliefs and values shared by the participants.
Wesson, Jacqueline Beth. "Functional Cognition in Older Adults with Mild Cognitive Impairment and Mild Dementia: Validation of the Large Allen's Cognitive Level Screen". Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/16961.
Testo completoMiranda, Diane da Costa. "Mini-addenbrookes cognitive examination (M-ACE) como instrumento de avaliação cognitiva breve no comprometimento cognitivo leve e doença de Alzheimer leve". Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-28092018-082520/.
Testo completoINTRODUCTION: The Mini-Addenbrooke\'s Cognitive Examination (M-ACE) consists of a brief cognitive assessment test composed of five items that aim to evaluate four main cognitive domains (orientation, memory, language and visuospatial function) with a maximum score of 30 points and a time of administration of five minutes. OBJECTIVE: Evaluate the performance of cognitively healthy elderly, MCI and mild AD in the Brazilian version of M-ACE. METHODS: The test was applied to a group of 23 patients with mild probable AD, 36 MCI and 25 cognitively healthy elderly. All included participants were aged >= 60 years. Patients with moderate or severe dementia, dementia of another etiology, severe comorbidities with potential to compromise cognition and use of psychotropic medication were excluded. The accuracy of the test was evaluated by analyzing the ROC curves. Spearman\'s correlation coefficients were used to analyze the relationship between the M-ACE scores and the other cognitive tests applied. In order to analyze the internal consistency of the M-ACE, the Cronbach\'s alpha coefficient was used. RESULTS: There was a predominance of females, mean age was 73 years, with a predominant age range of 60-69 years. The average level of schooling was 11 years. MACE presented high internal consistency (Cronbach\'s alpha > 0.8, 95% CI 0.776 to 0.869) and showed to be extremely capable of differentiating the AD group from the other participants, with a higher accuracy than the MMSE. The cutoff point of 20 was the one with the highest sensitivity and specificity (95.6% and 90.16%, respectively), with an AUC considered to be high (AUC = 0.805, 95% CI 0.705-0.904). The M-ACE presented better accuracy in differentiating the three groups when compared to the MMSE (71.43 versus 60.71). It was also observed a more robust precision in differentiating DA of MCI with M-ACE (63.89 versus 30.56 in MMSE). The total M-ACE score was not very influenced by age and schooling. M-ACE showed a strong correlation with MMSE (spearman = 0.78), as well as all items (except perception) of BBRC and QAF (spearman = -0.76). CONCLUSIONS: M-ACE can be considered a brief screening tool with high accuracy in the diagnosis of AD. The cutoff point suggested in this study is 20 for AD and 27 for MCI
Wang, Ji 1949. "Ren shi xi tong yun xing lun". Beijing : Zhongguo ren min da xue chu ban she, 1990.
Cerca il testo completoRudkin, Susan. "Executive processes in visual and spatial working memory tasks". Thesis, University of Aberdeen, 2001. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU140973.
Testo completoNovikova, Jekaterina. "Generic Cognitive Architecture for Real-Time, Embedded Cognitive Systems". Thesis, Blekinge Tekniska Högskola, Sektionen för datavetenskap och kommunikation, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-3889.
Testo completoOÌ, Maoldomhnaigh MicheaÌl. "Cognitive stage, cognitive style, attitude and physical science option". Thesis, King's College London (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.406231.
Testo completoDe, Marco Matteo. "Cognitive and physical stimulation, genetic risk and cognitive decline". Thesis, University of Sheffield, 2012. http://etheses.whiterose.ac.uk/3379/.
Testo completoOpdebeeck, Carol. "Cognitive reserve, mood, and cognitive function in later life". Thesis, Bangor University, 2015. https://research.bangor.ac.uk/portal/en/theses/cognitive-reserve-mood-and-cognitive-function-in-later-life(85dc8eae-9965-4d00-afd4-c59a59b69873).html.
Testo completoPatel, Avani Rajnikant. "Cognitive Rehab Solutions: A computer-assisted cognitive training program". CSUSB ScholarWorks, 2002. https://scholarworks.lib.csusb.edu/etd-project/2321.
Testo completoDu, Jia (Tina). "Multitasking, cognitive coordination and cognitive shifts during web searching". Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/35717/1/Jia_Du_Thesis.pdf.
Testo completoPeceguina, Maria Inês Duarte. "A competência social da criança em meio pré-escolar: Um modelo hierárquico no contexto das relações entre pares". Doctoral thesis, ISPA - Instituto Universitário, 2010. http://hdl.handle.net/10400.12/1107.
Testo completoIntegrados numa moldura desenvolvimental, os estudos apresentados nesta investigação avaliam um modelo de medidas para a competência social com os pares, durante o período pré-escolar. A competência social é definida como um traço latente de diferenças individuais que reflecte a capacidade das crianças para coordenar os afectos, cognição, e comportamento na realização de objectivos pessoais de natureza social (Waters & Sroufe, 1983). Adicionalmente, a concretização dos objectivos pessoais não deverá constituir um obstáculo à concretização dos objectivos pessoais dos pares, nem limitar a realização de objectivos futuros. O modelo de mensuração caracteriza-se por ter uma estrutura hierárquica de três níveis, onde a competência social se situa no nível de topo, enquanto factor latente de segunda ordem, com implicações nos três domínios da competência social, situados no nível latente inferior – motivação social e envolvimento, perfis de atributos comportamentais e psicológicos e aceitação de pares. Cada um destes domínios (as famílias de medidas) é medido através de dois ou três indicadores, constituindo a base do modelo (i.e., proporção de atenção visual recebida, proporção de interacções positivas e neutras iniciadas, dois Q-sorts da competência social, e duas medidas sociométricas). Foram testadas hipóteses sobre o ajustamento do modelo a dados Portugueses, bem como sobre a estabilidade do modelo durante o pré-escolar foram testadas. De um modo geral, os resultados foram consistentes com estudos anteriores (e.g., Bost, Vaughn, Washington, Cielinski, & Bradbard, 1998; Vaughn, 2001; Vaughn, et al., 2009), indicando que o modelo tem um bom ajustamento aos dados das crianças portuguesas. Adicionalmente, os resultados sustentam o pressuposto de que, embora pequenas diferenças de natureza cultural, desenvolvimental e de contexto social possam ocorrer ao nível das medidas (o nível base do modelo), a estrutura hierárquica é idêntica ao longo destas dimensões, uma vez que os domínios sociais considerados são considerados como universalmente relevantes para crianças desta faixa etária (i.e., entre os 3 e os 5 anos). A característica que melhor distingue o modelo hierárquico é que, contrariamente a outras abordagens, diversos conteúdos essenciais são considerados, e diversos tipos de instrumentos (e níveis de análise) são utilizados de modo a que seja possível obter uma descrição global da competência social (i.e., sem os constrangimentos situacionais, contextuais, ou dependentes de determinadas habilidades sociais). Como resultado, a avaliação da estabilidade é também possível. As relações entre a competência social, a amizade recíproca e o estatuto sociométrico (duas variáveis frequentemente utilizadas na avaliação da competência social das crianças) foram também exploradas no último estudo. Entre outros resultados, verificou-se que as medidas do modelo apresentavam maior estabilidade de um ano para outro, quer em comparação à amizade, quer ao estatuto sociométrico, sugerindo que a avaliação obtida através do protocolo de medidas é mais abrangente e consistente. As limitações de cada estudo, bem como orientações para futuras ---------- ABSTRACT ---------- Embedded in a developmental framework, the studies presented in this research investigate a measurement model for social competence with peers, during the preschool years. Social competence construct is described as an individual differences latent trait that reflects children’s ability in coordinating affect, cognition, and behavior in achieving personal social goals (Waters & Sroufe, 1983). Moreover, the attainment of personal goals should not excessively constrain peers’ opportunities in achieving their own social goals, or reduce the chances for the achievement personal social goals in the future. The measurement model characterizes by having a three-level hierarchical structure, where social competence is placed at the top level, as a second-order latent factor influencing three lower social competence domains – social motivation and engagement, profiles of behavioral and psychological attributes, and peer acceptance. Each of these domains (the measurement families) is measured using two or three indicators, which constitute the base level of the model (i.e., rates of visual attention received, rates of positive and neutral interactions initiated, two social competence Q-sorts, and two sociometric measures). Hypothesis regarding the fit of the model to Portuguese data, as well as the stability of the model across the preschool years were tested. Overall, results were consistent with prior studies (e.g., Bost, Vaughn, Washington, Cielinski, & Bradbard, 1998; Vaughn, 2001; Vaughn, et al., 2009), indicating that the model has a good fit to Portuguese preschool data. Results also support the assumption that, even though small differences associated with cultural, developmental, and social contexts variability may occur at the base level of the model (i.e., the observed measures/indicators), the hierarchical structure is identical across these dimensions, because the social domains considered are thought to be universally relevant to children at these ages (i.e., between the ages of 3-, and 5-years) The most distinguishable feature of the hierarchical model is that, contrary to other approaches, several main issues are taken into account, and several types of instruments (and levels of analyses) are used so that a broad characterization of social competence (i.e., non situational, or contextual, or skills’ based) is possible. As a result, the assessment of stability is also possible. The relations between social competence, friendship reciprocity, and sociometric status (two variables frequently assessed in the evaluation of children’s social competence) were also explored in the last study. Among other findings, the model’s measures was found to be more stable than both friendship and sociometric status, indicating that a broader and consistent assessment is given by the protocol of measures that are used in model operationalization. Limitations of each study and future directions of research are presented in the discussion section of each work, as well as in the general discussion.
Bolsa de Investigação SFRH/BD/23350/2005, financiada pelo Programa Operacional Ciência e Inovação (POCO 2010) da Fundação para a Ciência e Tecnologia
Quelhas, Ana Cristina. "Raisonnement conditionnel: Modeles mentaux et schemas pragmatiques". Doctoral thesis, Université de Provence, 1996. http://hdl.handle.net/10400.12/1834.
Testo completoTaillade, Mathieu. "Evaluation écologique des troubles de l'apprentissage et de la navigation dans les grands espaces liés au vieillissement : rôle des déclins mnésiques, exécutifs et du contrôle moteur". Phd thesis, Université Victor Segalen - Bordeaux II, 2012. http://tel.archives-ouvertes.fr/tel-00920503.
Testo completoGola-Asmussen, Céline. "La compréhension des phrases chez le lecteur débutant". Aix-Marseille 1, 2000. http://www.theses.fr/2000AIX10096.
Testo completoBauer, Corinna Mae. "Multimodal analysis in normal aging, mild cognitive impairment, and Alzheimer's disease: group differentiation, baseline cognition, and prediction of future cognitive decline". Thesis, Boston University, 2013. https://hdl.handle.net/2144/10937.
Testo completoAlzheimer's disease (AD) is a progressive neurodegenerative disease with an insidious onset that makes it difficult to distinguish from normal aging. It begins with an impairment of memory that develops into amnestic mild cognitive impairment (aMCI) and later to dementia as deficits become apparent in other cognitive domains. Effective biomarkers that differentiate normal aging, MCI, and AD and predict future cognitive decline are needed. Potential biomarkers have been studied in isolation, but their impact when combined is not understood. The goal of this project is to determine the optimal combination of CSF biomarkers, MRI morphometry, FDG PET metabolism, and neuropsychological test scores to differentiate between normal aging subjects and those with MCI and AD. This study addresses: 1) the optimal normalization region and partial volume correction method to quantify FDG PET analysis, 2) the effects of adjusting MRI-based cortical thickness measures for differences in gray/white matter tissue contrast in normal aging and disease, 3) whether multimodal multivariate stepwise logistic regression models can predict group membership, and 4) whether multimodal multivariate stepwise linear regression models can determine which imaging and CSF biomarker variables best predict future cognitive decline. The results indicate that normalizing FDG PET to the cerebellum along with using a gray matter mask for partial volume correction provides optimal prediction. In contrast, age-associated changes in gray/white matter intensity ratio did not differentiate between the groups and only slightly improved the efficacy of cortical thickness as a biomarker. MRI morphometry of the gray matter and neuropsychological test scores were better able to discriminate between the groups than FDG PET or CSF biomarker concentrations. Combining all modalities significantly improved the index of discrimination, especially at the earliest stages of the disease. MRI gray matter morphometry variables were more highly associated with baseline cognitive function and best predicted future cognitive decline compared to other variables. Overall these findings demonstrate that a multimodal approach using MRI morphometry, FDG PET metabolism, neuropsychological test scores, and CSF biomarkers provides significantly better discrimination than any modality alone. Hence, the variables important for discriminating between the groups may be candidates for biomarkers in human clinical interventional trials.