Letteratura scientifica selezionata sul tema "Claspers"

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Articoli di riviste sul tema "Claspers":

1

López-Jofré, Álvaro, Sebastián Hernández e Héctor Flores. "Description of the dermal denticles on pre-pelvic claspers of the Cockfish, Callorhinchus callorynchus (Holocephali: Callorhinchidae), from Coquimbo, Chile". Revista de Biología Marina y Oceanografía 58, n. 3 (31 dicembre 2023): 186–93. http://dx.doi.org/10.22370/rbmo.2023.58.3.4279.

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Chimaeras or Ghost sharks (Subclass Holocepahli) have sexual structures called pre-pelvic claspers, and these structures are covered by dermal denticles. In this study, dermal denticles present in pre-pelvic claspers of the Cockfish, Callorhinchus callorynchus, were described in order to compare them with those of other known species of this subclass. Pre-pelvic claspers of 22 specimens were removed for further examination. Dermal denticles on the flat surface of pre-pelvic claspers were different when examining their size, shape, and number of cusps. Dermal denticles were classified as type A (three cusps), B (four cusps), C (five cusps), D (six cusps) and E (eight cusps). Dermal denticles with fewer cusps were located near the center, whereas those with more cusps were located towards the periphery. All types of dermal denticles were found in the largest individuals (> 40 cm length). Possible functions of the dermal denticles and the pre-pelvic clasper in the reproductive activity of this species are suggested.
2

Ritter, EK, e LVJ Compagno. "Clasper Flaring: Maintenance Behavior, or a Normally Hidden Feature of Male Whitetip Reef Sharks, Triaenodon Obesus?" Open Fish Science Journal 6, n. 1 (8 marzo 2013): 10–12. http://dx.doi.org/10.2174/1874401x01306010010.

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Male whitetip reef sharks, Triaenodon obsesus, are able to pivot their claspers beyond regular flexing, including spreading their distal tips in a funnel like fashion. The feature of this extended clasper flexing, labelled clasper flaring, is described here. It is speculated to possibly reflect a pre- or post-copulation-related behavior.
3

Sephid, Hesam, Negin Salamat e Mohammad Ali Salari. "Sexual development and maturity of the male brown banded bamboo shark, Chiloscyllium punctatum (Elasmobranchii : Hemiscylliidae)". Marine and Freshwater Research 72, n. 8 (2021): 1160. http://dx.doi.org/10.1071/mf20305.

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The present study aimed to assess the reproductive biology of male brown banded bamboo shark (Chiloscyllium punctatum). Morphological and histological changes in the reproductive tract and changes in gonad steroid testosterone were assessed in 110 male C. punctatum collected from Bahrakan Creek between January 2018 and March 2019. The reproductive tract in male C. punctatum consisted of a pair of testes, efferent ducts, epididymidis, ductus deferens, seminal vesicles, Leydig gland and claspers. Four sexual development stages were determined: (1) immature, no calcified claspers (2) maturing, partially calcified claspers; (3) active and resting adults. Both adult resting and active stages had calcified claspers. In this study, immature male C. punctatum without calcified claspers were found from August to October, maturing C. punctatum with partially calcified claspers were found from November to January and adult C. punctatum caught from February to April were active with calcified claspers, whereas adult fish collected from May to July and during the rest of the year (until mid-January in the following year) were in the resting stage with inactive testes. The testis had a lobular structure and the spermatocysts were arranged diametrically (i.e. along the cross-sectional width of the testis) in each lobule. Plasma testosterone concentrations were associated with histomorphological changes in the reproductive tract. Testosterone concentrations peaked in March in active males and then decreased significantly in resting males. Overall, the variations in the reproductive organs during different sexual maturity stages were consistent with their roles in the production, movement and release of spermatozoa.
4

Dharmadi, Dharmadi. "ASPEK BIOLOGI IKAN PARI BLENTIK (Dasyatis cf. kuhlii) YANG TERTANGKAP DI LAUT JAWA". Jurnal Penelitian Perikanan Indonesia 14, n. 4 (8 febbraio 2017): 363. http://dx.doi.org/10.15578/jppi.14.4.2008.363-370.

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Penelitian dilakukan pada tahun 2002 sampai dengan 2003 di tempat pendaratan ikan Muara Angke dan Laboratorium Balai Riset Perikanan Laut Muara Baru, Jakarta. Data aspek biologi reproduksi ikan pari blentik (Dasyatis cf. kuhlii), berasal dari hasil tangkapan sampingan dari alat tangkap jaring dasar yang beroperasi di Laut Jawa dan didaratkan di tempat pendaratan ikan Muara Angke. Hasil penelitian menunjukkan ukuran lebar tubuh ikan pari blentik (Dasyatis cf. kuhlii) terkecil antara 170 sampai dengan 190 mm dan ukuran terbesar antara 330 sampai dengan 350 mm. Hubungan antara lebar cawan dan panjang klasper ikan pari blentik (Dasyatis cf. kuhlii) menunjukan hubungan yang linier (R2=0,7629). Kondisi klasper belum terjadi pengapuran atau sebagian mengandung zat kapur (non or partially calcified claspers) terdapat pada ukuran lebar tubuh <200 mm, sedangkan kondisi klasper penuh zat kapur (fully calcified claspers) terdapat pada ukuran lebar tubuh >250 mm. Ukuran embrio terkecil dijumpai pada bulan Januari yaitu antara 25 sampai dengan 30 mm dan terbesar antara 110 sampai dengan 115 pada bulan Agustus. Sebagian besar ikan pari blentik (Dasyatis cf. kuhlii) jantan yang tertangkap di Laut Jawa dalam kondisi matang kelamin. Berdasarkan pada uji X2, perbandingan kelamin jantan dan betina berbeda nyata (P<0,1). This study was conducted at Muara Angke fish landing site and Research Institute for Marine Fisheries Laboratory Muara Baru Jakarta on 2002 to 2003. Reproduction biology data of Dasyatis cf. kuhlii were taken from catched of bottom net fishing gear that operated in the Java Sea. The result showed that the smallest and the biggest of Dasyatis cf. kuhlii ranging from 170 to 190 mm and 330 to 350 mm disc width, respectively. Relationship between clasper length and disc width was linier (R2=0.7629). Condition of sex maturity stage of male was non or partially calcified claspers found at size <200 mm Wd, while fully calcified claspers was found at size >250 mm Wd. The smallest size embryo of ranging from 25 to 30 mm was found in January and the biggest ranging from 110 to 115 mm was found from in August. Most of Dasyatis cf. kuhlii caught in the Java Sea were mature. Sex ratio was significant different between male and female (X2 test, P<0.1).
5

Hagen, Joanna F. D., Cláudia C. Mendes, Amber Blogg, Alexander Payne, Kentaro M. Tanaka, Pedro Gaspar, Javier Figueras Jimenez, Maike Kittelmann, Alistair P. McGregor e Maria D. S. Nunes. "tartan underlies the evolution of Drosophila male genital morphology". Proceedings of the National Academy of Sciences 116, n. 38 (4 settembre 2019): 19025–30. http://dx.doi.org/10.1073/pnas.1909829116.

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Male genital structures are among the most rapidly evolving morphological traits and are often the only features that can distinguish closely related species. This process is thought to be driven by sexual selection and may reinforce species separation. However, while the genetic bases of many phenotypic differences have been identified, we still lack knowledge about the genes underlying evolutionary differences in male genital organs and organ size more generally. The claspers (surstyli) are periphallic structures that play an important role in copulation in insects. Here, we show that divergence in clasper size and bristle number between Drosophila mauritiana and Drosophila simulans is caused by evolutionary changes in tartan (trn), which encodes a transmembrane leucine-rich repeat domain protein that mediates cell–cell interactions and affinity. There are no fixed amino acid differences in trn between D. mauritiana and D. simulans, but differences in the expression of this gene in developing genitalia suggest that cis-regulatory changes in trn underlie the evolution of clasper morphology in these species. Finally, analyses of reciprocal hemizygotes that are genetically identical, except for the species from which the functional allele of trn originates, determined that the trn allele of D. mauritiana specifies larger claspers with more bristles than the allele of D. simulans. Therefore, we have identified a gene underlying evolutionary change in the size of a male genital organ, which will help to better understand not only the rapid diversification of these structures, but also the regulation and evolution of organ size more broadly.
6

Jones, Ashlee A., Norman G. Hall e Ian C. Potter. "Size compositions and reproductive biology of an important bycatch shark species (Heterodontus portusjacksoni) in south-western Australian waters". Journal of the Marine Biological Association of the United Kingdom 88, n. 1 (febbraio 2008): 189–97. http://dx.doi.org/10.1017/s0025315408000209.

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Heterodontus portusjacksoniwas obtained from the catches of commercial trawl, gillnet and longline fisheries operating in south-western Australian waters, in which this shark is an abundant bycatch species. Ninety per cent of theH. portusjacksonicaught by commercial trawling in a marine embayment were <400 mm in total length, whereas 99 and 100%, respectively, of the individuals taken by commercial gillnet and longline outside that embayment were >400 mm. Although the differences between the size compositions in the catches obtained by trawling vs both gillnetting and longlining, which were similar, are partly attributable to gear selectivity, they also reflect a use by juvenileH. portusjacksoniof protected nearshore waters as nursery areas and a tendency for larger juveniles and adults to occupy reef/rock habitats in a range of water depths. The fact that all but one of the numerousH. portusjacksoni>800 mm were females is reflected in the ratio of females to males differing significantly from parity in the gillnet and longline samples. Yolked oocytes usually take one year to develop to ovulatory size. Ovulation occurs in late winter to early summer and hatching takes place a year later when the embryo is 180–220 mm. The claspers of males commence rapid growth at a total length of ~450 mm, coincident with the onset of clasper calcification and gonadal maturation. The rate of clasper growth relative to total length reached a maximum at ~570 mm and then declined precipitously as the claspers approached full calcification. Based on gonadal criteria, theL50at maturity for females (805 mm) was nearly 40% greater than that for males (593 mm). Values of the deviance information criterion and marked overlap in their 95% confidence intervals demonstrate that theL50of 581 mm derived for males using full clasper calcification as the index of maturity was equally valid as the aboveL50derived for males at maturity using gonadal criteria. The capture of substantial numbers of juveniles by trawling and of females <L50at maturity by gillnetting and longlining may be having localized effects on the population structure ofH. portusjacksoniin south-western Australian waters.
7

CONANT, J. "ON A THEOREM OF GOUSSAROV". Journal of Knot Theory and Its Ramifications 12, n. 01 (febbraio 2003): 47–52. http://dx.doi.org/10.1142/s0218216503002299.

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In this paper, the easier methods of my thesis are applied to give a simple proof of a theorem of Goussarov. This theorem relates two possible notions of finite type equivalence of knots, links, or string links, showing that the resulting filtrations are the same up to a degree shift by a factor of two. This is then applied to the situation of rooted claspers to show that rooted clasper surgeries of sufficiently high degree must preserve type k invariants. As a consequence, grope cobordisms of sufficiently high class must preserve type k invariants. This result is applied in [CT] to show Theorem 2 of that paper.
8

WATANABE, TADAYUKI. "CLASPER-MOVES AMONG RIBBON 2-KNOTS CHARACTERIZING THEIR FINITE TYPE INVARIANTS". Journal of Knot Theory and Its Ramifications 15, n. 09 (novembre 2006): 1163–99. http://dx.doi.org/10.1142/s0218216506005056.

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Habiro found in his thesis a topological interpretation of finite type invariants of knots in terms of local moves called Habiro's Ck-moves. Ck-moves are defined by using his claspers. In this paper we define "oriented" claspers and RCk-moves among ribbon 2-knots as modifications of Habiro's notions to give a similar interpretation of Habiro–Kanenobu–Shima's finite type invariants of ribbon 2-knots. It works also for ribbon 1-knots. Furthermore, by using oriented claspers for ribbon 1-knots, we can prove Habiro–Shima's conjecture in the case of ℚ-valued invariants, saying that ℚ-valued Habiro–Kanenobu–Shima finite type invariant and ℚ-valued Vassiliev–Goussarov finite type invariant are the same thing.
9

Lessa, Rosângela Paula. "Contribuição ao conhecimento da biologia de Carcharhinus porosus Ranzani, 1839 (PISCES, CHONDRICHTHYES) das reentrâncias Maranhenses". Acta Amazonica 16 (1986): 73–86. http://dx.doi.org/10.1590/1809-43921986161086.

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184 machos da Carcharchinus porosas foram capturados com rede de emalhar nas Reentrâncias Maranhenses, entre Cururupu (1º 20' S e 45º W) e São Luis (2º 241 30'' S e 44º W) no período de outubro de 1983 à janeiro de 1984 e de junho à setembro de 1984. O desenvolvimento dos machos desta espécie foi estudado através da relação peso-comprimento e do crescimento: dos claspers, dos testículos, dos epidídimos e do fígado. Com exceção dos claspers e do fígado, o crescimento dos órgãos em questão é contínuo. No crescimento dos claspers evidenciou-se 3 fases que correspondem: a fase juvenil, a fase de adolescência e a fase adulta. Demonstrou-se, também, que existe uma descontinuidade no crescimento do fígado no momento da passagem da fase de adolescência à fase adulta, e que esta se verifica quando se relaciona o peso deste órgão com o peso corporal. Esfregaços do conteúdo da visívula seminal mostraram que o líquido branco presente neste órgão é livre de espermatozóides até 70 cm. Com base no crescimento dos claspers e na produção de espermatozóides normais, estabeleceu-se o tamanho de primeira maturidade em 71 cm (fim da fase de adolescência) e o tamanho de 100% de maturidade em 75 cm (início da fase adulta).
10

WHITE, WILLIAM T., FAHMI FAHMI e SIMON WEIGMANN. "A new genus and species of catshark (Carcharhiniformes: Scyliorhinidae) from eastern Indonesia". Zootaxa 4691, n. 5 (4 novembre 2019): 444–60. http://dx.doi.org/10.11646/zootaxa.4691.5.2.

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A new genus and species of catshark is described based on a single specimen collected off Ambon in the Maluku Islands of eastern Indonesia. Akheilos suwartanai belongs to the subfamily Schroederichthyinae which differs from the other catsharks in a combination of: similar sized dorsal fins, supraorbital crests present, pseudosiphon present on claspers, broad subocular ridges under eyes, posterior nasal flaps present, tips of rostral cartilage fused into a rostral node. It represents the first record of this subfamily outside of the Americas. Akheilos differs from the other genus in the subfamily, Schroederichthys in a combination of: clasper groove not fused dorsally, ventral lobe of caudal fin produced, more intestinal valve turns, anal fin slightly larger than second dorsal fin, and in colour pattern.

Tesi sul tema "Claspers":

1

Vance, Barbara R. "The Clasped Hands". Ann Arbor, Mich. : ProQuest, 2006. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:1430297.

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Thesis (M.A. in English)--S.M.U.
Title from PDF title page (viewed July 17, 2007). Source: Masters Abstracts International, Volume: 44-03, page: 1150. Adviser: Marshall Terry. Includes bibliographical references.
2

Graff, Emmanuel. ""Link-homotopy" in low dimensional topology". Electronic Thesis or Diss., Normandie, 2023. http://www.theses.fr/2023NORMC244.

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Ce mémoire explore la topologie de basse dimension, en mettant l'accent sur la théorie des nœuds. Une théorie consacrée à l'étude des nœuds tels qu'ils sont communément compris : des morceaux de ficelle enroulés dans l'espace ou, de manière plus générale, des entrelacs formés en prenant plusieurs bouts de ficelle. Les nœuds et les entrelacs sont étudiés à déformation près, par exemple, à isotopie près, ce qui implique des manipulations sans couper ni faire passer la ficelle à travers elle-même. Cette thèse explore la link-homotopie, une relation d'équivalence plus souple où des composantes distinctes demeurent séparées, mais où une composante donnée peut s'auto-intersecter. La théorie des claspers, des puissants outils de chirurgie, est développée à link-homotopie près. Leur utilisation permet une démonstration géométrique de la classification des entrelacs avec 4 composantes ou moins à link-homotopie près. Une attention particulière est ensuite accordée aux tresses, des objets mathématiques apparentés aux nœuds et aux entrelacs. Il est montré que le groupe de tresses homotopiques est linéaire, c'est-à-dire isomorphe à un sous-groupe de matrices. De nouvelles présentations de ce groupe sont également proposées. Enfin, il est établi que le groupe de tresse homotopique est sans torsion, quel que soit le nombre de composantes. Ce dernier résultat s'appuie sur le contexte plus large de la théorie des nœuds soudés
This thesis explores low-dimensional topology, with a focus on knot theory. Knot theory is dedicated to the study of knots as commonly understood: a piece of string tied in space or, more generally, links formed by taking several pieces of string. Knots and links are studied up to deformation, for example, up to isotopy, which involves manipulations that do not require cutting or passing the string through itself. This thesis explores link-homotopy, a more flexible equivalence relation where distinct components remain disjoint, but a single component can self-intersect. The theory of claspers, powerful tools of surgery, is developed up to link-homotopy. Their use allows for a geometric proof of the classification of links with 4 components or less up to link-homotopy. Special attention is then given to braids, mathematical objects related to knots and links. It is shown that the homotopy braid group is linear, meaning it is faithfully represented by a subgroup of matrices. New group presentations are also proposed. Finally, it is established that the homotopy braid group is torsion-free for any number of components. This last result draws upon the broader context of welded knot theory
3

Maia, Ana Rita Ramada. "Molecular regulation of human CLASPs during the cell cycle". Doctoral thesis, Faculdade de Medicina da Universidade do Porto, 2011. http://hdl.handle.net/10216/63771.

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Maia, Ana Rita Ramada. "Molecular regulation of human CLASPs during the cell cycle". Tese, Faculdade de Medicina da Universidade do Porto, 2011. http://hdl.handle.net/10216/63771.

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Maia, Ana Rita Ramada. "Molecular dissection of CLASPs function in mitosis: A proteomic approach". Master's thesis, Faculdade de Medicina da Universidade do Porto, 2007. http://hdl.handle.net/10216/22096.

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Mestrado em Medicina e Oncologia Molecular
Master Degree Course in Molecular and Oncology Medicine
CLASPs são proteínas altamente conservadas que participam na segregação dos cromossomas através do seu papel fundamental na interface cinetocoro-microtúbulo durante a mitose. Em levedura, Drosophila, e Xenopus, um único ortólogo da CLASP está presente, o qual é necessário para a formação do fuso mitótico através da regulação da dinâmica dos microtúbulos a nível do cinetocoro. Em mamíferos, no entanto, somente a CLASP1 tem sido implicada na divisão celular, apesar da existência de um segundo parólogo, CLASP2. Neste estudo descrevemos a localização mitótica da CLASP2 humana em células HeLa e mostramos que a sua localização nos cinetocoros, centrossomas, e fuso durante toda a mitose é notavelmente semelhante à CLASP1. A análise de fibroblastos embrionários de ratinho KO para a Clasp2 revelou que a localização da CLASP1 no cinetocoro e a resposta do checkpoint da Mad2 não estão comprometidos pela ausência de CLASP2. Para melhor compreender as funções das CLASPs em mitose, nomeadamente para determinar potenciais funções redundantes, nós realizamos a depleção de cada CLASP por RNAi. Notavelmente, a depleção isolada de cada CLASP não induziu qualquer erro significativo na mitose; a redução dos níveis de ambas as CLASPs por RNAi causou severos defeitos mitóticos a nível do fuso (principalmente células com fusos multipolares), e conteúdo anormal de DNA (aneuploidia). No geral, estes resultados sugerem que CLASP1 e CLASP2 possuem papéis sobreponíveis durante a mitose. A fim de compreender os mecanismos moleculares subjacentes à função das CLASPs humanas durante a mitose, nós realizamos um estudo proteómico para a identificação das proteínas interactoras da CLASP1 durante a mitose através de espectrometria de massa. Os nossos resultados confirmaram as interações entre CLASP1 - CLIP-170 e LL5ß, ambos descritas em interfase. Além disso, novas interacções foram encontradas como CENP-E, Astrin, GCC185, CENP-J/CPAP, MARK2 e a nova proteína KIAA0802. Em células interfásicas, as CLASPs acumulam-se no aparelho de Golgi e esta acumulação está relacionada com a presença de microtúbulos estabilizados. No entanto, há pouca informação a respeito da função de Golgi durante a mitose. A análise da distribuição mitótica da GCC185 mostrou que em estadios precoces a GCC185 localiza-se em torno dos centrossomas, e dispersa-se em metafase e anafase. Em telofase, a GCC185 relocaliza-se na região perinuclear e nos centrossomas. De notar que nós encontramos um co-localização extensiva entre a GCC185 e a CLASP1 (especialmente em profase, prometafase e telofase). A interacção entre a GCC185 e a CLASP1 foi também confirmada em extractos celulares interfásicos. Finalmente, muitas +TIPs como o APC, CLIP-170/Restin e EB1 têm sido implicadas em processos de aneuploidia e tumorigénese, formando uma complexa rede proteica com as CLASPs. Para determinar as implicações da CLASP1 nos mecanismos de tumorigénese, realizamos uma pesquisa mutacional numa linha celular humana derivada do carcinoma do cérvix (células HeLa). Na nossa análise mutacional encontramos três deleções: duas correspondem a isoformas da CLASP1 resultantes de splicing alternativo (737 1538 e 1125 1164), e a terceira deriva da perda parcial do exão 21 (673 679). Estas mutações podem estar relacionadas à instabilidade dos cromossomas que conduz a mutações aleatórias, ou podem reflectir que o gene CLASP1 é um alvo principal para mutações. Estes resultados incentivam a um exame maior para mutações da CLASP noutras linhas celulares tumorais e tumores primários. No geral, nós encontramos que a CLASP1 e CLASP2 possuem papéis redundantes durante a mitose, cuja ausência pode originar diversos defeitos mitóticos, conduzindo em último efeito à aneuploidia. Adicionalmente, descobrimos novas interacções moleculares com importantes proteínas mitóticas e fornecemos a ligação molecular entre a função da CLASP e o papel desconhecido do aparelho de Golgi durante a mitose.
CLASPs are well-conserved microtubule plus-end-tracking proteins that participate in chromosome segregation through their key role at the kinetochore-microtubule interface. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present, which is required for mitotic spindle assembly by regulating microtubule dynamics at the kinetochore. In mammals, however, only CLASP1 has been directly implicated in cell division, despite the existence of a second paralogue, CLASP2. Here we describe the mitotic localization of human CLASP2 in HeLa cells and show that its localization at kinetochores, centrosomes, and spindle throughout mitosis is remarkably similar to CLASP1. Analysis of Clasp2 KO mouse embryonic fibroblasts revealed that CLASP1 kinetochore localization and Mad2 checkpoint response is not compromised in the absence of CLASP2. To further understand CLASP roles in mitosis, namely to rule out potential redundant functions, we performed single CLASP depletion by RNAi. Remarkably, single CLASP depletion caused no significant impairment of mitosis, while reducing the levels of both CLASPs by RNAi caused severe mitotic spindle defects (mainly cells with multipolar spindles), and abnormal DNA content (aneuploidy). Overall, these results suggest that CLASP1 and CLASP2 play overlapping roles during mitosis. In order to understand the molecular mechanisms underlying the function of human CLASPs during mitosis, next we performed a proteomic study for the identification of CLASP1 interacting proteins during mitosis by mass-spectrometry. Our results confirmed the interactions between CLASP1 CLIP-170 and LL5ß, both described in interphase. Moreover, new interactors were found such as CENP-E, Astrin, GCC185, CENP-J/CPAP, MARK2 and the novel protein KIAA0802. In interphase cells, CLASPs accumulate at the Golgi apparatus and this accumulation is related to the presence of stabilized microtubules. However, there is little information concerning Golgi function during mitosis. Analysis of GCC185 mitotic distribution showed that in early stages GCC185 localizes around centrosomes, and disperses in metaphase and anaphase. In telophase, GCC185 re-localizes to the perinuclear region and centrosomes. Noteworthy, we found an extensive co-localization between GCC185 and CLASP1 (especially in prophase, prometaphase and telophase). The interaction between GCC185 and CLASP1 was also confirmed in interphase cell extracts. Finally, many +TIPs like APC, CLIP-170/Restin and EB1 have previously been implicated in aneuploidy and tumourigenesis, forming a complex protein network with CLASPs. To determine the implications of CLASP1 for the mechanisms of tumourigenesis, we performed a mutational screening in a human cell line derived from cervix carcinoma (HeLa cells). In our mutational analysis we found three deletions: two of them correspond to CLASP1 alternative spliced isoforms (737 1538 and 1125 1164), and the third derives from the partial loss of exon 21 (673 679). These mutations could be related to chromosomal instability leading to random mutations, or may reflect that CLASP1 gene is a main target for mutations. These results encourage a larger survey for CLASP mutations in other tumour cell lines and primary tumours. Overall, we found that CLASP1 and CLASP2 play redundant roles during mitosis, whose absence can originate several mitotic defects, and ultimately lead to aneuploidy. Additionally, we uncovered new molecular interactions with important and novel mitotic proteins and provided the molecular linkage between CLASP function and the still mysterious role of the Golgi apparatus during mitosis.
6

Baek, Changyeob. "Geometry-driven filamentary structures : elastic gridshells, weaves, clasps, and knots". Thesis, Massachusetts Institute of Technology, 2021. https://hdl.handle.net/1721.1/130841.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Mechanical Engineering, February, 2021
Cataloged from the official PDF of thesis.
Includes bibliographical references (pages 217-232).
In this thesis, we cover four research topics in the realm of the mechanics of slender structures involving strong geometric constraints: elastic gridshells, triaxial weaves, elastic clasps, and elastic knots. These studies involve a combination of geometric reasoning, high-fidelity numerical simulations, and precision model experiments using scale-invariance and advanced imaging techniques (e.g., 3D laser scanning, and X-ray computed tomography). First, we study the shape and the mechanical response of elastic gridshells, the three-dimensional structure of which results from the out-of-plane buckling of an initially flat and biaxial network of rods. A purely geometric continuum model, originally introduced by Chebyshev for woven fabric, is used to describe the underlying kinematics and form-finding. The results suggest that rod inextensibility, rather than elasticity, is the primary factor that determines the shape of elastic gridshells.
Second, we investigate triaxial weaving, a craft technique used to generate surfaces using tri-directional arrays of initially straight elastic ribbons. Traditional weavers intentionally introduce discrete topological defects, leading to unsmooth surfaces in the overall structure. As an alternative point of departure, we achieve smooth, threedimensional weaved structures by prescribing in-plane curvatures to the flat ribbons. We demonstrate that a continuous range of integrated Gaussian curvatures can be achieved, which is not feasible using straight ribbons. The potential of this novel design scheme is demonstrated with a few canonical target shapes.
Third, we investigate the mechanics of two elastic rods in a crossing contact, whose geometric counterpart is often referred to in the mathematics community as a 'clasp.' We compare our experimental and computational results to a well-established description for ideal clasps of geometrically rigid strings, finding that the latter acts as an underlying 'backbone' for the full elasticity solution. Our findings suggest that the tight contact between rods must be analyzed as a three-dimensional solid, not a one-dimensional rod. We also study a frictional elastic clasp with relative motion between the two rods. Finally, we present preliminary results on the full three-dimensional finite element method simulations of tight elastic knots, as a continuing discussion of tight contact between filaments. Our numerical results reveal significant deviations for the tight knots from existing one-dimensional models for loose overhand knots.
Our findings corroborate the three-dimensional nature of the tight contact that we demonstrated during the investigation of the elastic clasp.
by Changyeob Baek.
Ph. D.
Ph.D. Massachusetts Institute of Technology, Department of Mechanical Engineering
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Maia, Ana Rita Ramada. "Molecular dissection of CLASPs function in mitosis: A proteomic approach". Dissertação, Faculdade de Medicina da Universidade do Porto, 2007. http://hdl.handle.net/10216/22096.

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Abstract (sommario):
Mestrado em Medicina e Oncologia Molecular
Master Degree Course in Molecular and Oncology Medicine
CLASPs são proteínas altamente conservadas que participam na segregação dos cromossomas através do seu papel fundamental na interface cinetocoro-microtúbulo durante a mitose. Em levedura, Drosophila, e Xenopus, um único ortólogo da CLASP está presente, o qual é necessário para a formação do fuso mitótico através da regulação da dinâmica dos microtúbulos a nível do cinetocoro. Em mamíferos, no entanto, somente a CLASP1 tem sido implicada na divisão celular, apesar da existência de um segundo parólogo, CLASP2. Neste estudo descrevemos a localização mitótica da CLASP2 humana em células HeLa e mostramos que a sua localização nos cinetocoros, centrossomas, e fuso durante toda a mitose é notavelmente semelhante à CLASP1. A análise de fibroblastos embrionários de ratinho KO para a Clasp2 revelou que a localização da CLASP1 no cinetocoro e a resposta do checkpoint da Mad2 não estão comprometidos pela ausência de CLASP2. Para melhor compreender as funções das CLASPs em mitose, nomeadamente para determinar potenciais funções redundantes, nós realizamos a depleção de cada CLASP por RNAi. Notavelmente, a depleção isolada de cada CLASP não induziu qualquer erro significativo na mitose; a redução dos níveis de ambas as CLASPs por RNAi causou severos defeitos mitóticos a nível do fuso (principalmente células com fusos multipolares), e conteúdo anormal de DNA (aneuploidia). No geral, estes resultados sugerem que CLASP1 e CLASP2 possuem papéis sobreponíveis durante a mitose. A fim de compreender os mecanismos moleculares subjacentes à função das CLASPs humanas durante a mitose, nós realizamos um estudo proteómico para a identificação das proteínas interactoras da CLASP1 durante a mitose através de espectrometria de massa. Os nossos resultados confirmaram as interações entre CLASP1 - CLIP-170 e LL5ß, ambos descritas em interfase. Além disso, novas interacções foram encontradas como CENP-E, Astrin, GCC185, CENP-J/CPAP, MARK2 e a nova proteína KIAA0802. Em células interfásicas, as CLASPs acumulam-se no aparelho de Golgi e esta acumulação está relacionada com a presença de microtúbulos estabilizados. No entanto, há pouca informação a respeito da função de Golgi durante a mitose. A análise da distribuição mitótica da GCC185 mostrou que em estadios precoces a GCC185 localiza-se em torno dos centrossomas, e dispersa-se em metafase e anafase. Em telofase, a GCC185 relocaliza-se na região perinuclear e nos centrossomas. De notar que nós encontramos um co-localização extensiva entre a GCC185 e a CLASP1 (especialmente em profase, prometafase e telofase). A interacção entre a GCC185 e a CLASP1 foi também confirmada em extractos celulares interfásicos. Finalmente, muitas +TIPs como o APC, CLIP-170/Restin e EB1 têm sido implicadas em processos de aneuploidia e tumorigénese, formando uma complexa rede proteica com as CLASPs. Para determinar as implicações da CLASP1 nos mecanismos de tumorigénese, realizamos uma pesquisa mutacional numa linha celular humana derivada do carcinoma do cérvix (células HeLa). Na nossa análise mutacional encontramos três deleções: duas correspondem a isoformas da CLASP1 resultantes de splicing alternativo (737 1538 e 1125 1164), e a terceira deriva da perda parcial do exão 21 (673 679). Estas mutações podem estar relacionadas à instabilidade dos cromossomas que conduz a mutações aleatórias, ou podem reflectir que o gene CLASP1 é um alvo principal para mutações. Estes resultados incentivam a um exame maior para mutações da CLASP noutras linhas celulares tumorais e tumores primários. No geral, nós encontramos que a CLASP1 e CLASP2 possuem papéis redundantes durante a mitose, cuja ausência pode originar diversos defeitos mitóticos, conduzindo em último efeito à aneuploidia. Adicionalmente, descobrimos novas interacções moleculares com importantes proteínas mitóticas e fornecemos a ligação molecular entre a função da CLASP e o papel desconhecido do aparelho de Golgi durante a mitose.
CLASPs are well-conserved microtubule plus-end-tracking proteins that participate in chromosome segregation through their key role at the kinetochore-microtubule interface. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present, which is required for mitotic spindle assembly by regulating microtubule dynamics at the kinetochore. In mammals, however, only CLASP1 has been directly implicated in cell division, despite the existence of a second paralogue, CLASP2. Here we describe the mitotic localization of human CLASP2 in HeLa cells and show that its localization at kinetochores, centrosomes, and spindle throughout mitosis is remarkably similar to CLASP1. Analysis of Clasp2 KO mouse embryonic fibroblasts revealed that CLASP1 kinetochore localization and Mad2 checkpoint response is not compromised in the absence of CLASP2. To further understand CLASP roles in mitosis, namely to rule out potential redundant functions, we performed single CLASP depletion by RNAi. Remarkably, single CLASP depletion caused no significant impairment of mitosis, while reducing the levels of both CLASPs by RNAi caused severe mitotic spindle defects (mainly cells with multipolar spindles), and abnormal DNA content (aneuploidy). Overall, these results suggest that CLASP1 and CLASP2 play overlapping roles during mitosis. In order to understand the molecular mechanisms underlying the function of human CLASPs during mitosis, next we performed a proteomic study for the identification of CLASP1 interacting proteins during mitosis by mass-spectrometry. Our results confirmed the interactions between CLASP1 CLIP-170 and LL5ß, both described in interphase. Moreover, new interactors were found such as CENP-E, Astrin, GCC185, CENP-J/CPAP, MARK2 and the novel protein KIAA0802. In interphase cells, CLASPs accumulate at the Golgi apparatus and this accumulation is related to the presence of stabilized microtubules. However, there is little information concerning Golgi function during mitosis. Analysis of GCC185 mitotic distribution showed that in early stages GCC185 localizes around centrosomes, and disperses in metaphase and anaphase. In telophase, GCC185 re-localizes to the perinuclear region and centrosomes. Noteworthy, we found an extensive co-localization between GCC185 and CLASP1 (especially in prophase, prometaphase and telophase). The interaction between GCC185 and CLASP1 was also confirmed in interphase cell extracts. Finally, many +TIPs like APC, CLIP-170/Restin and EB1 have previously been implicated in aneuploidy and tumourigenesis, forming a complex protein network with CLASPs. To determine the implications of CLASP1 for the mechanisms of tumourigenesis, we performed a mutational screening in a human cell line derived from cervix carcinoma (HeLa cells). In our mutational analysis we found three deletions: two of them correspond to CLASP1 alternative spliced isoforms (737 1538 and 1125 1164), and the third derives from the partial loss of exon 21 (673 679). These mutations could be related to chromosomal instability leading to random mutations, or may reflect that CLASP1 gene is a main target for mutations. These results encourage a larger survey for CLASP mutations in other tumour cell lines and primary tumours. Overall, we found that CLASP1 and CLASP2 play redundant roles during mitosis, whose absence can originate several mitotic defects, and ultimately lead to aneuploidy. Additionally, we uncovered new molecular interactions with important and novel mitotic proteins and provided the molecular linkage between CLASP function and the still mysterious role of the Golgi apparatus during mitosis.
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Tannous, Fahed [Verfasser]. "Retentive forces and fatigue resistance of thermoplastic resin clasps / Fahed Tannous". Kiel : Universitätsbibliothek Kiel, 2013. http://d-nb.info/1042185697/34.

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Tse, Tsun-pang Edward, e 謝俊邦. "A comparison of the retentive characteristics of cast titanium and cobalt-chromium clasps". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31954248.

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Tse, Tsun-pang Edward. "A comparison of the retentive characteristics of cast titanium and cobalt-chromium clasps". Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25068490.

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Libri sul tema "Claspers":

1

Habiro, Kazuo. Brunnian links, claspers and Goussarov-Vassiliev finite type invariants. Kyoto, Japan: Research Institute for Mathematical Sciences, Kyoto University, 2005.

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2

Ryan, Lelia B. Officers' waist belt clasps 1855-1902. Chelsea: Military Historical Society, 1994.

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3

Jacobs, Kris Scott Hamilton. Families in transition: Hamilton, Clasper, and some allied families : some descendants of Peter and Helen (Falconer) Hamilton and George and Ann (Surtees) Clasper : additional families included. Fayetteville, AR (2915 S. Wright Pl., Fayetteville 72701-9127): Transitions Pub., 2002.

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4

Jacobs, Kris Scott Hamilton. Families in transition: Hamilton, Clasper, and some allied families : some descendants of Peter and Helen (Falconer) Hamilton and George and Ann (Surtees) Clasper : additional families included. Fayetteville, AR (2915 S. Wright Pl., Fayetteville 72701-9127): Transitions Pub., 2003.

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5

Dillon, Peter. The Tyne Oarsmen.: The Tyne Oarsmen: Harry Clasper, Robert Chambers, James Renforth. Newcastle upon Tyne, England: Keepdate Publishing Ltd., 1993.

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6

Read, Brian. Hooked-clasps & eyes: A classification & catalogue of sharp- or blunt-hooked clasps & miscellaneous objects with hooks, eyes, loops, rings or toggles. Langport: Portcullis Publishing, 2008.

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7

John, Hines. Clasps, hektespenner, agraffen: Anglo-Scandinavian clasps of classes A-C of the 3rd to 6th centuries A.D. : typology, diffusion and function. Stockholm: Kungl. Vitterhets historie och antikvitets akademien, 1993.

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8

Read, Brian. Hooked-clasps & eyes: A classification & catalogue of sharp- or blunt-hooked clasps & miscellaneous objects with hooks, eyes, loops, rings or toggles. Langport: Portcullis Publishing, 2008.

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9

Barta, Melinda A. Custom cool jewelry: Create 200+ personalized pendants, charms, and clasps. Loveland, Colo: Interweave Press LLC, 2008.

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10

Glogović, Dunja. Fibeln im kroatischen Küstengebiet (Istrien, Dalmatien). Stuttgart: F.Steiner, 2003.

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Capitoli di libri sul tema "Claspers":

1

Rayan, Ghazi M., e Joseph Upton III. "Congenital Clasped Thumb". In Congenital Hand Anomalies and Associated Syndromes, 343–48. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54610-5_26.

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2

Abdel-Ghani, Hisham, e Mostafa Mahmoud. "Congenital Clasped Thumb". In Congenital Anomalies of the Upper Extremity, 307–21. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-64159-7_19.

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3

Abdel-Ghani, Hisham, e Mostafa Mahmoud. "Congenital Clasped Thumb". In Congenital Anomalies of the Upper Extremity, 227–38. Boston, MA: Springer US, 2014. http://dx.doi.org/10.1007/978-1-4899-7504-1_18.

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4

Stark, Jean Reist, e Josephine Reist Smith. "Clasps and Terminations". In Classical Loop-in-Loop Chains and their Derivatives, 152–76. Boston, MA: Springer US, 1997. http://dx.doi.org/10.1007/978-1-4684-9132-6_9.

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5

Gebser, Martin, Roland Kaminski, Benjamin Kaufmann, Torsten Schaub e Bettina Schnor. "Cluster-Based ASP Solving with claspar". In Logic Programming and Nonmonotonic Reasoning, 364–69. Berlin, Heidelberg: Springer Berlin Heidelberg, 2011. http://dx.doi.org/10.1007/978-3-642-20895-9_42.

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6

Liu, Qin, e Leo S. Demski. "Clasper control in the round stingray, Urolophus halleri: lower sensorimotor pathways". In The reproduction and development of sharks, skates, rays and ratfishes, 219–30. Dordrecht: Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-017-3450-9_20.

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7

Yu, Haiyang. "How to Improve the Esthetics of Clasps". In Digital Removable Partial Denture Technology, 1–12. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-7923-1_1.

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Sandu, Liliana, Nicolae Faur, Cristina Borţun e Sorin Porojan. "Finite Element Analysis of Thermal Stresses in Circumferential Cast Clasps of Removable Partial Dentures". In Materials and Technologies, 229–32. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-460-x.229.

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9

Sawicki, Jakub. "Hooked Clasps and Where to Find Them: Similarities and Differences in Dress Accessories in Europe North of the Alps". In A United Europe of Things, 79–88. Cham: Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-48336-3_8.

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10

"Claspers". In Sharkpedia, 41–43. Princeton University Press, 2024. http://dx.doi.org/10.2307/jj.9266087.27.

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Atti di convegni sul tema "Claspers":

1

Willkommen, Jana. "New insights into the functional morphology of the claspers and copulatory organs of selected male damselflies". In 2016 International Congress of Entomology. Entomological Society of America, 2016. http://dx.doi.org/10.1603/ice.2016.93367.

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2

Losso, Sarah, e Javier Ortega-Hernandez. "CLASPER-LIKE APPENDAGES IN THE MID-CAMBRIAN TRILOBITE OLENOIDES SERRATUS FROM THE BURGESS SHALE". In GSA Connects 2021 in Portland, Oregon. Geological Society of America, 2021. http://dx.doi.org/10.1130/abs/2021am-365778.

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Giono, G., R. Ishikawa, Y. Katsukawa, T. Bando, R. Kano, Y. Suematsu, N. Narukage, Taro Sakao, K. Kobayashi e F. Auchère. "Current progress of optical alignment procedure of CLASP's Lyman-alpha polarimetry instrument". In SPIE Astronomical Telescopes + Instrumentation, a cura di Tadayuki Takahashi, Jan-Willem A. den Herder e Mark Bautz. SPIE, 2014. http://dx.doi.org/10.1117/12.2055704.

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4

Король, Г. Г. "DECORATED COMPOSITE CLASPS FROM THE SAYAN-ALTAI of the late 1st – early 2nd millennia". In Труды Сибирской Ассоциации исследователей первобытного искусства. Crossref, 2019. http://dx.doi.org/10.25681/iaras.2019.978-5-202-01433-8.175-195.

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Abstract (sommario):
Рассмотрены основные группы двусоставных украшений-застежек с территории Саяно-Алтая конца I начала II тыс. и прилегающих северных территорий. Предметы изготовлены из бронзы (сведена воедино известная информация о составе металла), декорированы. Группы выделены по принципу стилизации орнитоморфного образа (утки) и декорированию щитка застежки. В каждую группу вошли предметы, найденные и на западе (кимаки/кыпчаки), и на востоке (кыргызы) Саяно-Алтая. Прослежены возможные истоки декоративного воплощения мотива птицы (утки), региональные предпочтения декора. Культурное влияние кимаков/кыпчаков на северные территории подтверждается на изученном материале. Фиксируется и некоторое влияние кыргызов как поздний отголосок (XI XII вв.) периода их возвышения предшествующего времени, как полустертое воспоминание (таково и качество декора, и его понимание в новой среде) о некогда престижных и популярных предметах и их декоре The main groups of bipartite decorated clasps of the late 1st the early 2nd millennium from the Sayan-Altai region and the adjacent northern territories are considered. The objects are made of bronze (the paper summarizes already known information about the composition of the metal) and decorated. Groups are identified according to the styling of an ornithomorphic image (duck) and decorating the buckle shield. Each group includes items found both in the west (the Kimek and Kipchaks) and in the east (the Kyrgyz) of the Sayan-Altai. The author traces possible sources of the decorative realization of the bird motive (duck) and regional preferences of the decoration. The cultural influence of the Kimek/Kipchaks on the northern territories is confirmed by the studied material. Some influence of the Kyrgyz is also noted as a late echo (11th 12th cc.) of the preceding period of their elevation. It can be regarded as a half-erased memory (such was the quality of the decor, and its understanding in the new environment) of the once prestigious and popular objects and their dcor
5

Jensen, Brian D., e Larry L. Howell. "Identification of Compliant Pseudo-Rigid-Body Mechanism Configurations Resulting in Bistable Behavior". In ASME 2000 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/detc2000/mech-14147.

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Abstract (sommario):
Abstract Bistable mechanisms, which have two stable equilibria within their range of motion, are important parts of a wide variety of systems, such as closures, valves, switches, and clasps. Compliant bistable mechanisms present design challenges because the mechanism’s energy storage and motion characteristics are strongly coupled and must be considered simultaneously. This paper studies compliant bistable mechanisms which may be modeled as four-link mechanisms with a torsional spring at one joint. Theory is developed to predict compliant and rigid-body mechanism configurations which guarantee bistable behavior. With this knowledge, designers can largely uncouple the motion and energy storage requirements of a bistable mechanism design problem. Examples demonstrate the power of the theory in bistable mechanism design.
6

Krishnan, Sandeep, e Laxman Saggere. "Design of a Compliant Micro-Clasp Mechanism for Micromanipulation Tasks". In ASME 2007 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2007. http://dx.doi.org/10.1115/detc2007-35784.

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Abstract (sommario):
This paper introduces the concept of a novel compliant micromanipulator that is capable of manipulating irregularly shaped micro-scale objects by positively clasping the object. The controlled clasp capability of the micromanipulator can be useful to accomplish the manipulation of a wide range of micro-scale objects and biological specimens, especially those with irregular shapes and/or floating in a liquid medium where traditional tweezers or grippers are cumbersome or unsuitable. The monolithic structure of the micromanipulator comprises of two distinct parts: a body and a clasp. The body has a topology that magnifies a single rectilinear input actuation into two larger displacements at the input points to the clasp mechanism. The clasp mechanism comprises of rigid links connected by rotary joints in the form of low-resistance serpentine flexures. The mechanism “clasps” the target object by enveloping the object with a continuous mechanical boundary that eventually closes inwards and “locks” the object within the boundary. The paper presents a systematic design of the compliant micromanipulator and the analytical model governing the behavior of the clasp using topology optimization techniques and energy methods.

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