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Articoli di riviste sul tema "Cire inguinale"
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Kim, Kyoung Soo, Hari Madhuri Doss, Hee-Jin Kim e Hyung-In Yang. "Taurine Stimulates Thermoregulatory Genes in Brown Fat Tissue and Muscle without an Influence on Inguinal White Fat Tissue in a High-Fat Diet-Induced Obese Mouse Model". Foods 9, n. 6 (26 maggio 2020): 688. http://dx.doi.org/10.3390/foods9060688.
Testo completoAbstract (sommario):
This study was conducted to investigate if taurine supplementation stimulates the induction of thermogenic genes in fat tissues and muscles and decipher the mechanism by which taurine exerts its anti-obesity effect in a mildly obese ICR (CD-1®) mouse model. Three groups of ICR mice were fed a normal chow diet, a high-fat diet (HFD), or HFD supplemented with 2% taurine in drinking water for 28 weeks. The expression profiles of various genes were analyzed by real time PCR in interscapular brown adipose tissue (BAT), inguinal white adipose tissue (iWAT), and the quadriceps muscles of the experimental groups. Genes that are known to regulate thermogenesis like PGC-1α, UCP-1, Cox7a1, Cox8b, CIDE-A, and β1-, β2-, and β3-adrenergic receptors (β-ARs) were found to be differentially expressed in the three tissues. These genes were expressed at a very low level in iWAT as compared to BAT and muscle. Whereas, HFD increased the expression of these genes. Taurine supplementation stimulated the expression of UCP-1, Cox7a1, and Cox8b in BAT and only Cox7a1 in muscle, while there was a decrease in iWAT. In contrast, fat deposition-related genes, monoamine oxidases (MAO)-A, and -B, and lipin-1, were decreased by taurine supplementation only in iWAT and not in BAT or muscle. In conclusion, the potential anti-obesity effects of taurine may be partly due to upregulated thermogenesis in BAT, energy metabolism of muscle, and downregulated fat deposition in iWAT.
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Muto, Yuki, Akiomi Yoshihisa, Yukiko Sugawara, Satoshi Abe, Masayoshi Oikawa, ATSUSHI KOBAYASHI, Hiroyuki Kunii et al. "Abstract 10514: Inguinal Fat Tissue Biopsy to Identify Transthyretin Amyloidosis in Patients Undergoing Transcatheter Aortic Valve Implantation". Circulation 144, Suppl_1 (16 novembre 2021). http://dx.doi.org/10.1161/circ.144.suppl_1.10514.
Testo completoAbstract (sommario):
Background: Several studies have recently reported that transthyretin (ATTR) amyloidosis is present in patients with aortic stenosis (AS). This study aimed to 1) examine the utility of inguinal fat tissue biopsy in AS patients who underwent transcatheter aortic valve implantation (TAVI) to detect ATTR amyloidosis, 2) compare clinical characteristics between AS patients with ATTR (ATTR group) and those without ATTR (non-ATTR group). Methods and Results: We prospectively analyzed consecutive 56 patients who underwent transfemoral TAVI from December 2018 to December 2020 in our hospital. To screen ATTR in these patients, we performed inguinal fat tissue biopsy from cut down or puncture site during TAVI. Of 56 AS patients, 5 (8.9%) patients were diagnosed as ATTR by inguinal fat biopsy. Compared with non-ATTR group, ATTR group presented higher levels of B-type natriuretic peptide (BNP, 566.4 vs. 242.5 ng/ml, P=0.0045), higher levels of troponin I (0.053 vs. 0.024 ng/ml, P=0.003), lower left ventricular ejection fraction (LVEF, 49.3 vs. 60.3%, P=0.0035), larger left ventricular mass index (150.2 vs. 115.5 g/m 2 , P=0.019), larger aortic valve area (0.84 vs. 0.63 cm 2 , P=0.029) and lower peak velocity of aortic valve (3.8 vs. 4.4 m/s, P=0.041). In contrast, age, sex, STS score, clinical frailty scale, prevalence of diabetes, chronic kidney disease and AF, levels of albumin, and eGFR were comparable between the two groups. Electrocardiogram and other echocardiographic parameters including interventricular septal wall thickness, posterior wall thickness, stroke volume index and E/A ratio did not differ between the two groups. Although TAVI was successfully completed in all patients, the incidence of life-threatening bleeding and 30-day readmission was higher in ATTR group than in non-ATTR group (40.0 vs. 5.9%, P=0.011 and 20.0 vs. 0.0%, P=0.001). There was no difference in occurrence of myocardial infarction, stroke, acute kidney injury, major vascular complication, pacemaker implantation and 30-day mortality. Conclusions: In AS patients, especially in those with increased BNP and troponin I levels and low-flow low-gradient pattern, ATTR should be considered. In this population, inguinal fat tissue biopsy is a novel and safe approach to identify ATTR.
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Hu, Ruoci, Jooman Park, Shaolei Xiong, Pingwen Xu e Yuwei Jiang. "Abstract 4145171: The CCL22/CCR4 Axis Promotes Beige Adipocyte Formation". Circulation 150, Suppl_1 (12 novembre 2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4145171.
Testo completoAbstract (sommario):
Introduction: Beige adipocytes hold therapeutic promise for obese and diabetic patients. Beige adipocytes can be generated from tissue-residing beige progenitors (APCs) in response to cold temperatures preferably around lymph nodes (LN), suggesting that there are unique LN-derived signals controlling beige adipocyte generation. Methods: CCR4 KO mice (spCas9 mice were injected with AAV8-CCR4-sgRNA into biolateral inguinal adipose tissue) were generated on a C57BL/6 background. Stromal vascular cells were isolated and differentiated into beige adipocytes for in vitro studies. Flow cytometer analysis were conducted for sorting and identifying immune cells. Results: Here, we show that local LN removal greatly impairs cold-induced beiging, and this impairment can be restored by injecting M2 macrophages or macrophage-derived chemokine C-C motif ligand 22 (CCL22) into iWAT. Mechanistically, cold exposure increases the level of CCL22, which binds to its receptor C-C chemokine motif receptor 4 (CCR4), and then promotes beiging. Furthermore, CCL22 levels are inversely correlated with body weight and fat mass, and elevated CCL22 levels prevent diet-induced obesity along with increased energy expenditure in mice and humans. Conclusion: The results suggest that beige adipogenesis around the inguinal LNs of white adipose tissues depends on the CCL22-CCR4 signaling. Our findings underline the potential of targeting the CCL22-CCR4 axis to counter obesity and its associated health complications.
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Sharma, Swapna, Abiah Pritchard, Michael Young e Stanislav Henkin. "Abstract 13946: Subclinical Atherosclerosis and Peri-Operative Cardiac Events in Patients Undergoing Peripheral Bypass Surgery". Circulation 144, Suppl_1 (16 novembre 2021). http://dx.doi.org/10.1161/circ.144.suppl_1.13946.
Testo completoAbstract (sommario):
Introduction: Coronary artery disease (CAD) is associated with a higher risk of peri-operative adverse events after vascular surgery. Subclinical CAD, defined as presence of coronary calcium, has not been established as a risk factor for adverse events after vascular surgery. Hypothesis: We sought to describe the epidemiology and peri-operative outcomes in patients with subclinical coronary atherosclerosis (SCA) undergoing supra- and infra-inguinal peripheral bypass. Methods: Using the Vascular Quality Initiative, we identified patients at a single institution undergoing supra- and infra-inguinal peripheral bypass surgery (2009-2020). Retrospective chart review was performed to identify chest computed tomography (CT) within one year prior to revascularization; imaging was reviewed for presence of coronary calcifications, a marker of SCA. Individuals were stratified by: no atherosclerosis, SCA, and CAD. Comorbidities and peri-operative outcomes were compared among groups with the chi-square or ANOVA, as appropriate. Results: Of 1018 patients undergoing peripheral bypass surgery, 199 (20%) had a CT available. SCA was noted in 96 patients (48%) while 72 (36%) had known CAD. Patients with SCA had similar comorbidities to patients with CAD (Table) but were less likely to be on a pre-operative beta-blocker or P2Y12 inhibitor. The incidence of postoperative myocardial infarction and congestive heart failure was similar in patients with SCA (13% and 9%, respectively) as those with CAD (10%, 6% respectively), compared to those without atherosclerosis (3% and 0, respectively). Conclusions: SCA is common in patients undergoing peripheral bypass surgery and is associated with a risk of peri-operative myocardial infarction or congestive heart failure similar to occult CAD. Aggressive secondary prevention measures should be considered in patients with polyvascular disease, including subclinical CAD.
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Quintero Bisono, Janina, Bistees George e Kori Ormachea. "Abstract 15479: High Output Cardiac Failure Associated With Arteriovenous Fistula". Circulation 148, Suppl_1 (7 novembre 2023). http://dx.doi.org/10.1161/circ.148.suppl_1.15479.
Testo completoAbstract (sommario):
Introduction: High output heart failure (HOHF) secondary to arteriovenous fistula (AVF) is known. However, having a high index of suspicion for the latter when encountering diuretic resistance in patients with a remote history of hemodialysis is key. Case A 68-year-old female with a history of kidney transplant in 2012 with no recent dialysis, hypertension, hyperlipidemia, pulmonary hypertension, heart failure with reduced ejection fraction, and atrial fibrillation presented with decompensated heart failure and acute kidney injury (AKI). Physical exam was remarkable for anasarca, and no apparent fistulas were noted. She was started on milrinone and furosemide drips. Clinical decision making Initial transthoracic echocardiogram (TTE) revealed an ejection fraction (EF) of 20%, which declined from 35%, along with new mitral and tricuspid regurgitation. Her hospitalization was complicated by altered mental status, worsening AKI requiring hemodialysis, atrial fibrillation with rapid ventricular response, and resistance to multiple diuretics and after-load reduction combinations. Diuretics and inotropic support were discontinued due to worsening clinical status. Given concerns for valvular disease, a transesophageal echocardiogram was obtained, confirming moderate to severe mitral and tricuspid valve regurgitation, bi-atrial enlargement, and reduced biventricular function. However, the patient was not clinically optimized for Mitra-clip. Further hemodynamics and volume status assessment with RHC revealed a mean PAP 44, PCWP 26, and CO 11 L/min. RHC results raised suspicion for HOHF. Interestingly, the patient was noted to have a right inguinal surgical scar with a palpable thrill, and an arteriovenous graft duplex revealed high volume flow. The patient underwent ligation of the right inguinal fistula. Repeat TTE two weeks post AVF ligation showed EF of 40% and improved functional mitral and tricuspid valve regurgitation. The patient ultimately was taken off hemodialysis and had clinically improved heart failure. GDMT was optimized, and outpatient evaluation for mitral valve intervention was scheduled. Conclusion Longstanding AVF can cause HOHF. Early index of suspicion is warranted for AVF ligation as it results in rapid EF recovery.
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Ravi, Srekar, George Bcharah, Christine Firth, Austin Saugstad, Mayowa Osundiji, Yuxiang Wang, Chadi Ayoub e Fadi Shamoun. "Abstract 4146529: Impact of Connective Tissue Features on Vascular Outcomes in Fibromuscular Dysplasia". Circulation 150, Suppl_1 (12 novembre 2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4146529.
Testo completoAbstract (sommario):
Introduction/Background: Fibromuscular Dysplasia (FMD) is a non-atherosclerotic vascular disease that primarily affects medium-sized arteries and is characterized by abnormal cell development in the artery walls. Recent studies have suggested that various connective tissue features may be prevalent in patients with FMD, however the clinical significance of these findings on the disease course are uncertain. Research Questions/Hypothesis: We hypothesized that the presence of connective tissue features in patients with FMD might indicate a more severe disease course, potentially associated with increased severity of vascular complications. Goals/Aims: To evaluate the association between connective tissue features and the severity of vascular complications in FMD patients on outcomes including dissections and stroke. Methods/Approach: This cross-sectional study involved 2,454 patients diagnosed with FMD at a tertiary referral center. Patients were classified into two groups based on the presence (n=324) or absence (n=2130) of connective tissue features (pectus deformity of any kind, scoliosis, pneumothorax, inguinal hernia, uterine rupture, bowel perforation, Achilles tendon rupture). We evaluated the incidence of dissections and ischemic or hemorrhagic strokes using odds ratios and chi-squared tests. Results/Data: The cohort consisted of 2,454 participants with an average age of 64.8 years, of whom 89.1% were female and 92.4% identified as White. When comparing groups with and without connective tissue features, there were no significant differences in the prevalence of aneurysms at any site. Among the subgroup of FMD patients with connective tissue features (n=234), prevalent conditions included pectus (12.35%), scoliosis (47.22%), pneumothorax (16.67%), inguinal hernia (13.58%), uterine rupture (16.36%), bowel perforation (6.48%), and Achilles tendon rupture (1.85%). Vascular outcome analysis showed significant differences: the odds of experiencing a stroke were higher in patients with these features (odds ratio: 1.60; P-value: <0.01), whereas the odds of experiencing dissections were lower (odds ratio: 0.77; P-value: 0.03). Conclusion: The presence of connective tissue features in patients with FMD is associated with 60% higher odds of experiencing a stroke, equivalent to a 1.6-fold increase, compared to those without these features. This association may represent a novel finding in the literature, warranting further investigation.
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Ahiskalioglu, Elif O., Erkan C. Celik, Binali Firinci, Miraç S. Ozkal, Ibrahim H. Tor, Irem Ates, Ozgur Ozmen e Ali Ahiskalioglu. "Eficacia del bloqueo del plano de la fascia transversal en la reparación de la herniotomía inguinal pediátrica: estudio controlado aleatorizado". Cirugía y Cirujanos, 20 novembre 2024. http://dx.doi.org/10.24875/ciru.24000008.
Testo completo
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Turan, Umit, e Ahmet Baris-Dirim. "Predicción de la proporción de aspartato aminotransferasa a alanina aminotransferasa (De Ritis) para detectar necrosis intestinal en pacientes con hernia inguinal incarcerada". Cirugía y Cirujanos 91, n. 4 (30 agosto 2023). http://dx.doi.org/10.24875/ciru.22000273.
Testo completo
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Solís-De la Cruz, J. Ramón, Gustavo Leal-Mérida e Enrique O. Guadarrama-Díaz. "Comparación de las características epidemiológicas, clínicas y quirúrgicas de pacientes con y sin recidiva de hernias inguinales operados en el Centro Médico Naval". Cirugía y Cirujanos 90, n. 6 (2 novembre 2022). http://dx.doi.org/10.24875/ciru.21000500.
Testo completo
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Wilson, Robin, Lakshmi Arivazhagan, Henry Ruiz, Jay Pendse, Laura Frye, Kaamashri Mangar, Ravichandran Ramasamy e Ann Marie SCHMIDT. "Abstract 17023: Adipose Tissue Specific Temporal Deletion of Ager Induces Weight Loss in Diet Induced Obese Mice and Improves Glucose Homeostasis". Circulation 142, Suppl_3 (17 novembre 2020). http://dx.doi.org/10.1161/circ.142.suppl_3.17023.
Testo completoAbstract (sommario):
Introduction: The incidence of obesity and its comorbidities is increasing at an alarming rate in US and around the globe. Our previous studies showed that the receptor for advanced glycation end products (RAGE) and its ligands contribute to the pathogenesis of obesity and insulin resistance (IR), as global Ager (gene encoding RAGE) and adipocyte-specific Ager- deleted mice fed a high fat diet (HFD) showed protection from weight gain and IR. However, the role of Ager deletion in mice with established obesity, switched to low fat diet has not been tested. We hypothesize that temporal adipocyte-specific deletion of Ager in obese mice could enhance weight loss and improves glucose homeostasis. Methods: Mice with conditional adipocyte-specific Ager deletion were generated by breeding Ager flox/flox mice with AdipoQ ERT2 Cre recombinase mice resulting in Ager flox/flox / AdipoQ ERT2 Cre (+) and Cre (-) animals. Mice were fed HFD (60% kcal/fat) for 20 weeks starting at 8 weeks of age to establish obesity and were then treated with tamoxifen (TAM) (75 mg/kg per day x 3 alternative days) to induce deletion of Ager . After 4 weeks of TAM treatment, mice were switched to standard chow for 7 weeks and body weight was monitored regularly. Fasting glucose, insulin and glucose tolerance was measured. Results: After 7 weeks of switching to standard chow following TAM, Cre (+) lost significantly more body weight whereas Cre (-) mice showed no significant weight loss over 7 weeks. Furthermore, Cre (+) mice exhibited significantly higher food intake, lower fasting glucose, lower epididymal and inguinal white adipose tissue weights, and improved glucose and insulin tolerance compared to Cre (-) mice. Conclusions: Temporal adipocyte-specific deletion of Ager in mice with established obesity promotes weight loss and improves glucose homeostasis. RAGE may act as a novel therapeutic target in obesity.
Tesi sul tema "Cire inguinale"
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Alary, Justine. "La communication olfactive entre la brebis et l’agneau via la cire inguinale et son application dans l’optimisation de l’adaptation néonatale en élevage". Electronic Thesis or Diss., Bourgogne Franche-Comté, 2024. http://www.theses.fr/2024UBFCK055.
Testo completoAbstract (sommario):
Le bien-être animal est défini comme un état positif lié à la satisfaction des besoins physiologiques et comportementaux des animaux. Un aspect crucial de ce bien-être est la capacité d’exprimer des comportements naturels, comme la relation mère-jeune chez les mammifères. Chez les brebis, des signaux olfactifs spécifiques, tels que la cire inguinale (CI), jouent un rôle essentiel en aidant les agneaux à localiser les mamelles pour téter et en renforçant leur lien avec la mère. En élevage, certains agneaux sont placés en allaitement artificiel (AA), ce qui les prive de leur mère et des signaux olfactifs naturels, entraînant un stress accru, des difficultés d’apprentissage et un taux de mortalité plus élevé.Cette thèse explore comment la CI pourrait être utilisée pour améliorer l'adaptation des agneaux en AA. Les résultats obtenus montrent que la présence de CI favorise la croissance d’agneaux en AA et a un effet attractif sur eux, mais elle ne suffit pas à elle seule pour optimiser l’apprentissage de la tétée artificielle. Cette thèse suggère qu’il est nécessaire de poursuivre les recherches sur les odeurs maternelles pour mieux comprendre leur rôle et leur potentiel à améliorer les pratiques d’élevage, avec pour objectif final de renforcer le bien-être des animaux et leur adaptation aux conditions d’élevage non naturellesAnimal welfare is defined as a positive state related to the fulfilment of the animals' physiological and behavioural needs. A crucial aspect of this welfare is the ability to express natural behaviours, such as the mother-young bond in mammals. In ewes, specific olfactory signals, such as inguinal wax (IW), play an essential role in helping lambs locate the teats for suckling and in strengthening their bond with the mother. In farming, some lambs are placed in artificial rearing (AR), which deprives them of their mother and natural olfactory signals, leading to increased stress, learning difficulties, and higher mortality rates.This thesis explores how IW could be used to improve the adaptation of lambs in AR. The results show that the presence of IW promotes lamb growth in AR and has an attractive effect on them, but it alone is not sufficient to optimize the learning of artificial suckling. This thesis suggests that further research on maternal odors is necessary to better understand their role and potential to improve farming practices, with the ultimate goal of enhancing animal welfare and their adaptation to unnatural farming conditions