Bibliografie tematiche / Cheng zhong xiao xue

Letteratura scientifica selezionata sul tema "Cheng zhong xiao xue"

Autore: Grafiati
Pubblicato: 26 luglio 2024

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Articoli di riviste sul tema "Cheng zhong xiao xue"

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Ma, Xiaowei, Bryan D. Wood e Brian Way. "Application of Tetraethylsulfamide (TES) As a Cathode Additive in Cylindrical Cells". ECS Meeting Abstracts MA2022-01, n. 2 (7 luglio 2022): 357. http://dx.doi.org/10.1149/ma2022-012357mtgabs.

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Recently, sulfonamides have been shown to be promising electrolyte components due to their high chemical and electrochemical stability in lithium batteries [1, 2]. The electrolyte stability becomes critical when applying high voltage and/or utilizing Ni-rich layered oxides in high energy density lithium-ion batteries. Another approach to successful Ni-rich cathode performance is to develop a stable and effective cathode electrolyte interphase (CEI). Given the success of sultones and sulfates in this regard [3, 4], it is hypothesized that nitrogen analogs, like sulfonamides, could be tailored to provide a similar benefit. Indeed, Yim et al. [5, 6] have shown that N,N,N’,N’-tetraethylsulfamide (TES) forms a CEI on NMC811 that imparts high voltage cycling stability and less cathode corrosion. Our earlier studies of TES with Ni-rich NCA also formed a favorable CEI and these results are the topic of this presentation. Herein, we examine the performance of 0 - 4 wt.% TES in our commercially available, high power INR18650-P28A. These cells contain a composite SiO/graphite anode in addition to a Ni-rich cathode. As shown in Fig 1, TES significantly decreased the impedance of the cathode interface after conditioning compared to the control electrolyte. Thereafter, cells containing up to 2%TES show improved capacity retention during long-term high-rate cycling (+1C/-80W). Part of this success was due to a suppression of resistance growth during cycling by TES. Fast charge cycling (+3C/-2C), however, was moderately impaired with increased TES. Considering the largely reduced impedance of the cathode, fast-charge performance may have suffered due to anode rate limitations. These results will be discussed as well as gas generation, storage performance, and additional rate and cycling tests. [1] Shuting Feng, Mingjun Huang, Jessica R. Lamb, Wenxu Zhang, Ryoichi Tatara, Yirui Zhang, Yun Guang Zhu, Collin F. Perkinson, Jeremiah A. Johnson, Yang Shao-Horn. Chem, 5, 2630-2641 (2019) [2] Weijiang Xue, Mingjun Huang, Yutao Li, Yun Guang Zhu, Rui Gao, Xianghui Xiao, Wenxu Zhang, Sipei Li, Guiyin Xu, Yang Yu, Peng Li, Jeffrey Lopez, Daiwei Yu, Yanhao Dong, Weiwei Fan, Zhe Shi, Rui Xiong, Cheng-Jun Sun, Inhui Hwang, Wah-Keat Lee, Yang Shao-Horn, Jeremiah A. Johnson, Ju Li. Nature Energy, 6, 495-505 (2021) [3] Koji Abe, Manuel Colera, Kei Shimamoto, Masahide Kondo, Kazuhiro Miyoshi. Journal of Electrochemical Society, 161 (6) A863-A870 (2014) [4] Jian Xia, N. N. Sinha, L. P. Chen, J. R. Dahn. Journal of Electrochemical Society, 161 (3) A264-A274 (2014) [5] Kwangeun Jung, Taeeun Yim. Journal of Alloys and Compounds, 834,155155 (2020) [6] Ji Won Kim, Kwangeun Jung, Taeeun Yim. Journal of Mater. Sci & Tech. 86, 70-76 (2021) Figure 1
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Hu, Jia, Jun Ni, Longxian Jiao, Jinghong Zhou, Shiming Fan, Renxiang Tang, Wei Zhang et al. "Abstract 6321: HMPL-453, a highly selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays potent activity in FGFR-altered tumor models". Cancer Research 83, n. 7_Supplement (4 aprile 2023): 6321. http://dx.doi.org/10.1158/1538-7445.am2023-6321.

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Abstract Background: Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular processes. Dysregulation of FGFR signaling due to receptor fusion, mutation or amplification is observed across multiple cancer types, making activated FGFRs an important therapeutic target. Herein, we present the preclinical characterization of HMPL-453, a highly potent and selective inhibitor of FGFR1, 2, and 3, discovered and being currently developed in phase II clinical trial (NCT04353375) by HUTCHMED. Methods: Kinase activity was measured by Transcreener™ Fluorescence Polarization assay or Z’-LYTE kinase assay. In vitro anti-proliferation activity was measured by CellTiter-Glo luminescent or CCK-8 assay. The effect of HMPL-453 on FGFR signaling pathway was detected by western blot. Multiple tumor models with FGFR alteration were applied in Nu/Nu nude mice to determine anti-tumor efficacy of 453 as a single agent. A model in immune-competent BALB/c mice inoculated with the constructed NIH/3T3 cells carrying FGFR2-AHCYL1 fusion was chosen to investigate the combination effect of HMPL-453 with anti-PD-1 antibody. Results: HMPL-453 potently inhibited the tyrosine kinase activities of recombinant FGFR 1, 2, and 3 in vitro (IC50 values of 6, 4, and 6 nM, respectively) with weaker activity against FGFR4 (IC50 = 425 nM). HMPL-453 selectively inhibited proliferation of tumor cell lines with dysregulated FGFR signaling (GI50s: 3~105 nM) compared with cell lines lacking FGFR aberrations (GI50s > 1.5 µM). HMPL-453 demonstrated strong inhibition of phosphorylation of FGFR and downstream protein in tumor cell lines harboring FGFR2 fusion. Oral administration of HMPL-453 could induce time- and dose-dependent inhibition of phosphorylation of FGFR and resulted in remarkable and dose-dependent anti-tumor activity in multiple FGFR-altered tumor models. HMPL-453 at the dose of 50 mg/kg/day could induce tumor regression in most tumor models tested. Moreover, HMPL-453 significantly improved anti-tumor activity of anti-PD-1 antibody in a FGFR2 fusion model by priming the immune environment. Conclusion: HMPL-453 is a highly potent and selective inhibitor of FGFR 1, 2, and 3 with strong activity against FGFR-deregulated tumors in preclinical models, supporting continued investigation in patients with FGFR alterations (such as fusion and mutation) either as a single agent or in combination with PD-1 blockade. Citation Format: Jia Hu, Jun Ni, Longxian Jiao, Jinghong Zhou, Shiming Fan, Renxiang Tang, Wei Zhang, Xuelei Ge, Qihang Zhang, Juntao Yu, Ying Yu, Dongxia Shi, Min Cheng, Weifang Xue, Sumei Xia, Zeyu Zhong, Jian Wang, Yang Sai, Weiguo Qing, Guangxiu Dai, Yongxin Ren, Michael Shi, Weiguo Su. HMPL-453, a highly selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays potent activity in FGFR-altered tumor models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 6321.
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Tseng, Chu-Yao, Ching-Wen Huang, Hsin-Chia Huang e Wei-Chen Tseng. "Utilization Pattern of Traditional Chinese Medicine among Fracture Patients: A Taiwan Hospital-Based Cross-Sectional Study". Evidence-Based Complementary and Alternative Medicine 2018 (30 settembre 2018): 1–9. http://dx.doi.org/10.1155/2018/1706517.

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Traditional Chinese medicine (TCM) divides fracture treatment into three stages. Many TCM herbs and formulas have been used to treat fractures for thousands of years. However, research regarding the Chinese herbal products (CHPs) that should be used at different periods of treatment is still lacking. This study aims to identify the CHPs that should be used at different periods of treatment as well as confirm the TCM theory of fracture periods medicine. We used prescriptions of TCM outpatients with fracture diagnoses analyzed using the Chang Gung Research Database (CGRD) from 2000 to 2015. According to the number of days between the date of the fracture and the clinic visit date, all patients were assigned to one of three groups. Patients with a date gap of 0-13 days were assigned to the early period group; those with a date gap of 14-82 days were assigned to the middle period group; and those with a date gap of 83-182 days were assigned to the late period group. We observed the average number of herbal formulas prescribed by the TCM doctor at each visit was 2.78, and the average number of single herbs prescribed was 6.47. The top three prescriptions in the early fracture period were Zheng-gu-zi-jin-dang, Shu-jing-huo-xue-tang, and Wu-ling-san. In the middle fracture period, the top three formulas were Zheng-gu-zi-jin-dang, Shu-jing-huo-xue-tang, and Zhi-bai-di-huang-wan. In the late fracture period, the top three formulas were Shu-jing-huo-xue-tang, Gui-lu-er-xian-jiao, and Du-huo-ji-sheng-tang. The main single herbs used in the early fracture period were Yan-hu-suo, Gu-sui-bu, and Dan-shen. From the middle to the late period, the most prescribed single herbs were Xu-duan, Gu-sui-bu, and Yan-hu-suo. We concluded that the results showed that the CGRD utilization pattern roughly meets the TCM theory at different fracture periods.
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Xiao, Rui. "Yi Zhong Qiu Tong: Zhong Guo Dang Dai Yi Xue Shu Yu De Dong Tai Xing Cheng [Seeking Understanding from Differences: The Dynamic Formation of Chinese Contemporary Translation Terminology]". Australian Journal of Linguistics 39, n. 2 (21 maggio 2017): 271–75. http://dx.doi.org/10.1080/07268602.2017.1311293.

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Zhang, Mengzhe. "POLYPHONIC GENRES IN PIANO CREATIVITY OF CHINESE COMPOSERS". Aspects of Historical Musicology 24, n. 24 (13 ottobre 2021): 148–65. http://dx.doi.org/10.34064/khnum2-24.08.

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Abstract (sommario):
Statement of the problem. The twentieth century marked an increased interest in polyphonic music. The geography of polyphonic works for piano expanded significantly and a creative development of many Chinese composers, writing polyphonic piano pieces, took place. Today, polyphonic pieces make up a significant part of the piano repertoire in China, but they are little studied by musicologists and performers. The objective of this study – to reveal the contribution of Chinese composers to the creation of polyphonic piano repertoire of the XX – early XXI century. Analysis of the research and publications on the theme. А large number of modern authors study polyphony from the point of physical and mathematical research methods (Igarashi, Yu. & Ito, Masashi & Ito, Akinori, 2013; Weiwei, Zhang & Zhe, Chen, & Fuliang, Yin, 2016; Li, Xiaoquan et al. others, 2018). This approach does not reveal the factual musical component of polyphonic genres. In the 20th century, musicologists explored polyphony in musical folklore (Wiant, 1936; Fan Zuyin, 2004; Li Hong, 2015) and in professional Chinese composing (Sun Wei-bo, 2006, Winzenburg, 2018). The scientific novelty. This article studies the role of Chinese composers in the development of the world polyphonic piano repertoire of the XX – early XXI century. The methodological basis for the analysis of polyphonic works was the theoretical concepts of P. Hindemith, Peng Cheng, Fang Zuin, Li Hong, Sun Wei-bo. The results of the study. The research outcomes demonstrate the evolutionary development of the genre diversity of Chinese piano polyphony as well as those composers who created magnificent musical pieces. Conclusions. Chinese composers have fully mastered the art of modern counterpoint, represented by the genres of polyphonic program pieces (He Lu Ting), invention (Xiao Shu Xian, Du Qian, Sun Yun Yin, Chen Chen Quang), polyphonic suite (Ma Gui), large polyphonic cycle ( He Shao, Chen Hua Do, Xiao Shu Xian), fugue (Li Jun Yong, Yu Su Yan, Chen Gang, Tian Lei Lei, Duan Ping Tai, Zheng Zhong, Xiao Shu Xian) and small cycle “Prelude and Fugue” (Ding Shan Te, Chen Zhi Ming, Wang Li Shan). Creatively assimilating and rethinking the experience of Western polyphonists, Chinese composers have filled their polyphonic works with national features, firmly linking them with the origins of Chinese traditional and folk music. The polyphonic way of transmitting musical material becomes the most expressive at the moments of profound creativity and musical dramatization.
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Yeung, Bryan K., Xiao Hui Koh, Wei Li Ling, Weiqi Tan, You Xue Wu, Xi Yun Zhang, Hong Yee Tan, Shao Jun Liu, Chen Zhong e Bin Zou. "Abstract 3137: Development of AT2604, a highly efficacious ADC targeting alkaline phosphatases ALPP and ALPPL2​". Cancer Research 84, n. 6_Supplement (22 marzo 2024): 3137. http://dx.doi.org/10.1158/1538-7445.am2024-3137.

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Abstract Placental alkaline phosphatases, ALPP and ALPPL2, are highly homologous, membrane-bound proteins involved in fetal development. Despite having limited expression in normal tissues, they are highly differentiated in tumor cells making them ideal targets for antibody drug conjugate (ADC) development. AT2604 is an ADC that consists of a humanized IgG1 anti-ALPP/ALPPL2 antibody that displays specificity over other human alkaline phosphatases and is cross reactive to NHP ALPPL2 but not to murine ALPPL2. The anti-ALPP/ALPPL2 antibody shows high target binding affinity and internalization into ALPP and ALPPL2 positive cells.​ AT2604 utilizes AxcynCYSTM technology for site-specific conjugation to achieve a highly homogeneous (>97%) DAR4 ADC product. The payload is the clinically validated microtubule disrupting agent monomethyl auristatin E (MMAE) conjugated to the antibody via a protease-cleavable peptide linker approved for ADC use. When evaluated in mouse xenograft models of gastric (NCI-N87) and pancreatic (HPAC) cancer, AT2604 displayed strong tumor growth inhibition (>90%) at 1 mg/kg (QW3 × 2 dosing) in both models. Furthermore, a pre-tox study in non-human primates concluded AT2604 has a HNSTD of 10 mg/kg (QW3 × 3 dosing) and did not exhibit any non-reversible adverse effects; implying that AT2604 possesses an improved safety profile over other vedotin-based ADCs. Taken together, the data supports the continued development of AT2604 towards evaluation in human trials.​ Citation Format: Bryan K. Yeung, Xiao Hui Koh, Wei Li Ling, Weiqi Tan, You Xue Wu, Xi Yun Zhang, Hong Yee Tan, Shao Jun Liu, Chen Zhong, Bin Zou. Development of AT2604, a highly efficacious ADC targeting alkaline phosphatases ALPP and ALPPL2​ [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3137.
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Drewniak, Łukasz, e Sabina Drewniak. "The influence of the oxidation method on the properties of reduced graphene oxide". Photonics Letters of Poland 14, n. 3 (30 settembre 2022): 47. http://dx.doi.org/10.4302/plp.v14i3.1154.

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Derivatives of graphene have become important materials due to their excellent properties. Graphene oxide and reduced graphene oxide are especially interesting because they are produced relatively easily, cheaply and quickly. Among many possible applications, reduced graphene oxide is a good candidate for sensor applications. Its properties can be controlled at the production stage. The precursor used and the method of oxidation have a significant influence on its properties. Therefore, it is worth take a closer look at them. In this paper we analyse the influence of the oxidation method on the size of the reduced graphene stock which determine the sensitivity of the rGO layer. We used AFM microscopy for this purpose. Full Text: PDF ReferencesS.M. Majhi, A. Mirzaei, H.W. Kim, S.S. Kim, "Reduced Graphene Oxide (rGO)-Loaded Metal-Oxide Nanofiber Gas Sensors: An Overview", Sensors 21, 4 (2021). CrossRef M. Pumera, "Graphene-based nanomaterials for energy storage", Energy Environ. Sci. 4 3 (2011). CrossRef X. Yu, H. Cheng, M. Zhang, Y. Zhao, L. Qu, G. Shi, "Graphene-based smart materials", Nat. Rev. Mater. 2, 9 (2017). CrossRef M.Y. Xia, Y. Xie, C.H. Yu, G.Y. Chen, Y.H. Li, T., Zhang, Q. Peng, "Graphene-based nanomaterials: the promising active agents for antibiotics-independent antibacterial applications", J. Control. Release 10 (2019). CrossRef X. Zhu, Y. Zhou, Y. Guo, H. Ren, C. Gao, "Nitrogen dioxide sensing based on multiple-morphology cuprous oxide mixed structures anchored on reduced graphene oxide nanosheets at room temperature", Nanotechnology 30 45 (2019). CrossRef Z. Wu, Y. Wang, S. Ying, M. Huang, C. Peng, "Fabrication of rGO/Cuprous Oxide Nanocomposites for Gas Sensing", IOP Conf. Ser.: Earth Environ. Sci. 706, 1 (2021). CrossRef S. Pei, H.M. Cheng, "The reduction of graphene oxide", Carbon 50, 9 (2012). CrossRef K. Spilarewicz-Stanek, A. Kisielewska, J. Ginter, K. Bałuszyńska, I. Piwoński, "Elucidation of the function of oxygen moieties on graphene oxide and reduced graphene oxide in the nucleation and growth of silver nanoparticles", RSC Adv. 6, 65 (2016). CrossRef R. Muzyka, S. Drewniak, T. Pustelny, M. Sajdak, Ł. Drewniak, "Characterization of Graphite Oxide and Reduced Graphene Oxide Obtained from Different Graphite Precursors and Oxidized by Different Methods Using Raman Spectroscopy Statistical Analysis", Materials 14, 4 (2021) CrossRef B. Lesiak, G. Trykowski, J. Tóth, et al. "Chemical and structural properties of reduced graphene oxide—dependence on the reducing agent", J Mater. Sci. 56 (2021). CrossRef .
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Tan, Ban Xiong, Xi Yun Zhang, You Xue Wu, Yin Wen Cheng, Shao Jun Liu, Ping Du, Chen Zhong e Bin Zou. "Abstract 1858: Discovery of AT86474, a highly efficacious anti-ROR1 ADC utilizing a proprietary payload". Cancer Research 84, n. 6_Supplement (22 marzo 2024): 1858. http://dx.doi.org/10.1158/1538-7445.am2024-1858.

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Abstract ROR1 is a pseudo kinase that is involved in the non-canonical Wnt signaling pathway and is highly expressed during early embryonic development. In adult tissues, ROR1 is expressed at very low levels but its increased expression is observed in hematological cancers and a broad range of solid tumors. AT86474 is a highly homogeneous antibody drug conjugate incorporating AxcynCYSTM technology that allows reproducible site-specific conjugation with DAR4 composition greater than 97%. AT86474 utilizes a proprietary payload derived from an FDA approved drug that was optimized in-house for increased potency and with altered PK properties to limit systemic exposure. In vitro, the payload displays broad sub-nanomolar activity across multiple cancer cell lines, including those resistant to paclitaxel, DM1, MMAE and DXd. The payload is conjugated via an enzyme-cleavable linker optimized for solubility, stability, and high drug to antibody ratios. AT86474 uses a humanized and optimized monoclonal antibody that demonstrates selective binding to ROR1-positive cells and subsequent internalization, sub-nanomolar potency in vitro and strong bystander effects. AT86474 was evaluated in a preclinical CDX mouse model of ovarian cancer, where substantial tumor growth inhibition was observed with two weekly doses at as low as 1 mg/kg. As ROR1 over-expression is also observed in many solid tumors, such as pancreatic, gastric, breast and lung cancers, the use of AT86474 can be expanded to benefit a large patient population. Citation Format: Ban Xiong Tan, Xi Yun Zhang, You Xue Wu, Yin Wen Cheng, Shao Jun Liu, Ping Du, Chen Zhong, Bin Zou. Discovery of AT86474, a highly efficacious anti-ROR1 ADC utilizing a proprietary payload [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1858.
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Drewniak, Sabina Elżbieta, Roksana Muzyka e Łukasz Drewniak. "The structure of thermally reduced graphene oxide". Photonics Letters of Poland 12, n. 2 (1 luglio 2020): 52. http://dx.doi.org/10.4302/plp.v12i2.1021.

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The paper focused on the description of the reduced graphene oxide (rGO) structure. This material is obtained from a multistage production process. Each of these stages has a large impact on its structure (the number and type of functional groups, number of defect or the size of the flakes), and this in turn affects its properties. We would like to visualize the reduced graphene oxide, both using a diagram showing the atomic structure, as well as by imaging using scanning electron microscopy (SEM) and atomic force microscopy (AFM). In the paper, the elementary composition of selected elements and data obtained from X-ray photoelectron spectroscopy technique (XPS) will be also presented. Full Text: PDF ReferencesX. Peng, Y. Wu, N. Chen, Z. Zhu, J. Liu, and H. Wang, "Facile and highly efficient preparation of semi-transparent, patterned and large-sized reduced graphene oxide films by electrochemical reduction on indium tin oxide glass surface", Thin Solid Films 692, 137626 (2019). CrossRef L. Guo, Y.-W. Hao, P.-L. Li, J.-F. Song, R.-Z. Yang, X.-Y. Fu, S.-Y. Xie, J. Zhao and Y.-L. Zhang, "Improved NO2 Gas Sensing Properties of Graphene Oxide Reduced by Two-beam-laser Interference", Sci. Rep. 8, 1 (2018). CrossRef Y. S. Milovanov, V.A. Skryshevsky, , O.M. Slobodian, , D.O. Pustovyi, X.Tang, J.-P. Raskin, and A.N. Nazarov, "Influence of Gas Adsorption on the Impedance of Graphene Oxide", 2019 IEEE 39th Int. Conf. Electron. Nanotechnology, ELNANO 2019 - Proc. 8783946, CrossRef M. Reddeppa, B.-G. Park, , M.-D. Kim, K.R. Peta, N.D. Chinh, D. Kim, S.-G. Kim, and G. Murali, "H2, H2S gas sensing properties of rGO/GaN nanorods at room temperature: Effect of UV illumination", Sensors Actuators B. Chem. 264, (2018). CrossRef W. L. Xu, C. Ding, , M.-S. Niu, X.-Y. Yang, F. Zheng, J. Xiao, M. Zheng and X.-T. Hao, "Reduced graphene oxide assisted charge separation and serving as transport pathways in planar perovskite photodetector", Org. Electron. 81, 105663 (2020). CrossRef K. Sarkar, M. Hossain, P. Devi, K. D. M. Rao, and P. Kumar, "Self‐Powered and Broadband Photodetectors with GaN: Layered rGO Hybrid Heterojunction", Adv. Mater. Interfaces, 6, 20 (2019). CrossRef S. Pei and H. M. Cheng, "The reduction of graphene oxide", Carbon, 50, 9 (2012). CrossRef R. Muzyka, S. Drewniak, T. Pustelny, M. Chrubasik, and G. Gryglewicz, "Characterization of Graphite Oxide and Reduced Graphene Oxide Obtained from Different Graphite Precursors and Oxidized by Different Methods Using Raman Spectroscopy", Materials 11, 7 (2018). CrossRef M.-H. Tran and H. K. Jeong, "Influence of the Grain Size of Precursor Graphite on the Synthesis of Graphite Oxide", New Phys. Sae Mulli, 63, 2 (2013). CrossRef M.-H. Tran, C.-S. Yang, S. Yang, I.-J. Kim, and H. K. Jeong, "Influence of graphite size on the synthesis and reduction of graphite oxides", Curr. Appl. Phys., 14, SUPPL. 1 (2014). CrossRef N. Sharma, Y. Jain, , M. Kumari, R. Gupta, S.K. Sharma, K. Sachdev, "Synthesis and Characterization of Graphene Oxide (GO) and Reduced Graphene Oxide (rGO) for Gas Sensing Application", Macromol. Symp. 376, 1 (2017). CrossRef M. Wei, L. Qiao, , H. Zhang, S. Karakalos, K. Ma, Z. Fu, M.T. Swihart, G. Wu, "Engineering reduced graphene oxides with enhanced electrochemical properties through multiple-step reductions", Electrochim. Acta, 258 (2017). CrossRef S. Drewniak, M. Procek, R. Muzyka, T. Pustelny, "Comparison of Gas Sensing Properties of Reduced Graphene Oxide Obtained by Two Different Methods", Sensors, 20, 11 (2020). CrossRef L. Li, R.-D. Lv, S. -C. Liu, Z. D. Chen, J. Wang, Y.-G. Wang, W. Ren, "Using Reduced Graphene Oxide to Generate Q-Switched Pulses in Er-Doped Fiber Laser", Chinese Physics Letters, 35, 11 (2018) CrossRef
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Lv, Hong, Qian-Ming Bai, Yin Liu, Zhong-Hua Wang, Ruo-Hong Shui, Hong-Fen Lu, Xiao-Li Xu et al. "Abstract P2-13-11: Response to anti-HER2 neoadjuvant chemotherapy in invasive breast cancers with different HER2 FISH-positive patterns". Cancer Research 82, n. 4_Supplement (15 febbraio 2022): P2–13–11—P2–13–11. http://dx.doi.org/10.1158/1538-7445.sabcs21-p2-13-11.

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Abstract Backgrounds: Since human epidermal growth factor receptor 2 (HER2)-positive breast cancers may have different HER2/CEP17 ratios and HER2 copy numbers, outcomes of HER2-positive breast cancer patients treated with anti-HER2 neoadjuvant chemotherapy (NACT) may be different. The aim of this study is to explore the relationship between different groups of HER2 fluorescence in situ hybridization (FISH) positive patterns and response to anti-HER2 NACT. Methods: 513 HER2-positive invasive breast cancers who received anti-HER2 NACT in Fudan University Shanghai Cancer Center, during January 2015 to September 2020, were collected. According to FISH results, 513 patients were divided into three groups. Group A: HER2/CEP17 < 2.0 and HER2 average copy number ≥6.0; Group B: HER2/CEP17≥2.0 and HER2 average copy number ≥4.0 and < 6.0; Group C: HER2/CEP17≥2.0 and HER2 average copy number ≥6.0. Clinicopathological characteristics and pathological complete response(pCR) rates of three groups were analyzed. Results: All 513 patients were treated with anti-HER2 NACT. The anti-HER2 treatment included trastuzumab in 463 (90.3%) patients, trastuzumab plus pertuzumab in 21 (4.1%) patients, trastuzumab plus lapatinib in 3 (0.6%) patients, and trastuzumab plus pyrotinib in 1 (0.2%) patient. 25 (4.9%) cases were unblinded in clinical trials, who were treated either with trastuzumab plus pertuzumab or with trastuzumab plus pyrotinib. Among 513 patients, 237 cases (46.2%)were luminal B (hormone receptor positive and HER2 positive) and 276 cases (53.8%) were hormone receptor negative and HER2 overexpressed (HER2 overexpression type). According to IHC results, cases with HER2 1+,2+ and 3+ were 8 (1.6%), 123 (24.0%) and 382(74.5%), respectively. Among them, 0.0%, 25.2%, and 48.7% achieved pCR (p<0.001). The pCR rate of HER2 overexpression type was higher than that of luminal B type (54.0% vs 28.7%, P<0.001). Lymph nodes with metastasis after NACT in luminal B type was higher than that of HER2 overexpression type (43.0% vs 21.4%, P<0.001). According to HER2-FISH results, 11 cases (2.1%) were group A, 28 cases (5.5%) were group B and 474 cases (92.4%) were group C. Compared with the pCR rate of group A (36.4%) and group C (44.5%), the pCR rate in group B (7.1%) was significantly lower (p<0.001). Conclusions: Among HER2-positive breast cancers, HER2 protein expression level was positively correlated with pCR rate. Luminal B(HER2+)patients benefited less from anti-HER2 NACT than HER2 overexpression patients. Although all were invasive breast cancers with positive HER2-FISH results, patients with HER2/CEP17≥2.0 and HER2 copy number ≥4.0 and <6.0 seemed to respond less favorably to anti-HER2 NACT compared with other groups. The biological characteristics of this group of patients are worthy of further study. Citation Format: Hong Lv, Qian-Ming Bai, Yin Liu, Zhong-Hua Wang, Ruo-Hong Shui, Hong-Fen Lu, Xiao-Li Xu, Bao-Hua Yu, Xiao-Yu Tu, Rui Bi, Yu-Fan Cheng, Xiao-Yan Zhou, Zhi-Min Shao, Wen-Tao Yang. Response to anti-HER2 neoadjuvant chemotherapy in invasive breast cancers with different HER2 FISH-positive patterns [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr P2-13-11.
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Chan, Yuen-nga. "Yun yong pian zhang jie gou ce lüe ti sheng zhong san xue sheng yue du shuo ming wen de cheng xiao". Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B4255374X.

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Sit, Fung-ming Joyce. "A study of the composing process of primary six pupils starting = Xianggang xiao liu xue sheng Zhong wen xie zuo si wei guo cheng : wen zhang de kai shi /". Click to view the E-thesis via HKUTO, 1998. http://sunzi.lib.hku.hk/hkuto/record/B31960406.

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Chan, Kok-chi. "Effectiveness of computer-assisted learning in Chinese language Dian nao fu zhu zhong wen yue du jiao xue zhi cheng xiao ping gu /". Click to view the E-thesis via HKUTO, 1998. http://sunzi.lib.hku.hk/hkuto/record/B31959969.

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Chan, Lai-wa, e 陳麗華. "The investigation of the effectiveness of process writing method to enhance the practical writing ability of international school students who learn Chinese as a second language = Guo cheng xie zuo jiao xue fa dui ti sheng guo ji xue xiao Zhong wen wei di er yu yan xue sheng xie zuo ying yong wen zhi cheng xiao yan jiu". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/209681.

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Wong, Yan-nar. "The development of Chinese writing curriculum in primary school in Hong Kong, 1975-1990 Xianggang xiao xue Zhong wen xie zuo ke cheng de fa zhan (1975-1990) /". Click to view the E-thesis via HKUTO, 1996. http://sunzi.lib.hku.hk/hkuto/record/B31959118.

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Sim, Seok-hwa. "The use of blogging to enhance the learning of chinese writing in secondary school students in Singapore Zhong wen wang zhi xie zuo dui ti sheng Xinjiapo zhong xue sheng xie zuo neng li yu tai du zhi cheng xiao yan jiu /". Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40888022.

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Tang, Suk-yin. "The effectiveness of enhancing form seven students' speaking proficiency through cognitive training Si wei neng li xun lian dui ti sheng zhong qi xue sheng shuo hua neng li de cheng xiao yan jiu /". Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37648068.

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To, Suk-kwan. "The effectiveness of a reading module in enhancing junior students' reading motivation and conceptual knowledge Ti sheng chu zhong xue sheng yue du dong ji ji wen hua zhi shi dan yuan jiao xue cheng xiao yan jiu /". Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/hkuto/record/B40039985.

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Kwan, Che-ying. "A school-based case study an evaluation of the implementation of the "British National Writing Project" in Chinese writing programme = Yi ge xiao ben de ge an yan jiu : Yingguo "Guo jia xie zuo ji hua" zai Zhong wen xie zuo jiao xue shi jian de cheng xiao ping gu /". Click to view the E-thesis via HKUTO, 1995. http://sunzi.lib.hku.hk/hkuto/record/B31957900.

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Zhu, Xinhua. "A study on the development of superstructure of narrative text written by primary school pupils in four cities of China = Zhong guo si ge cheng shi xiao xue sheng ji xu wen pian zhang de shang ceng jie gou de fa zhan yan jiu /". Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23295922.

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Libri sul tema "Cheng zhong xiao xue"

1

Tai, Shuangqiu. Zhong xiao xue ke cheng wen ti. [Beijing: Beijing zhong xian tuo fang ke ji fa zhan you xian gong si, 2012.

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Tai, Shuangqiu. Zhong xiao xue ke cheng wen ti. Beijing: Beijing zhong xian tuo fang ke ji fa zhan you xian gong si, 2007.

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Wang, Jucheng. Cheng chang de lü hang. 8a ed. Beijing: Zhongguo shao nian er tong chu ban she, 2014.

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kun, Ji fu. Zhong wai wen xue jiao cheng. Shen yang: Liao ning mei zhu chu ban she, 2004.

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Wenshui Xian cheng zhen zhong xue xiao zhi bian zuan wei yuan hui. Wenshui Xian cheng zhen zhong xue xiao zhi (1988-2013). Taiyuan: Shanxi ren min chu ban she, 2013.

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Haiyin, Lin. Cheng nan jiu shi: Xue sheng du ben. Zhangchun: Ji lin chu ban ji tuan you xian ze ren gong si, 2010.

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Yang, Gongying. Zhong cheng de liu lang gou. 8a ed. Hang zhou: Zhejiang shao nian er tong chu ban she, 2014.

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Shen, Shixi. Zhong cheng de shi zi gou. Hefei: An hui shao nian er tong chu ban she, 2016.

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liang, Zhang guang. Cheng gong jiao shi bi zhi de 22 tiao "jun gui". Cheng dou: Dian zi ke ji ta xue chu ban she, 2008.

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Carlyle, David. Tian kong zhi cheng: Feng zhong qun dao. Wuhan: Hu bei shao nian er tong chu ban she, 2011.

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Capitoli di libri sul tema "Cheng zhong xiao xue"

1

Taber, Douglass F. "Organocatalytic Carbocyclic Construction: The Christmann Synthesis of (+)-Rotundial". In Organic Synthesis. Oxford University Press, 2013. http://dx.doi.org/10.1093/oso/9780199965724.003.0069.

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Abstract (sommario):
Karl Anker Jørgensen of Aarhus University found (Angew. Chem. Int. Ed. 2009, 48, 6650) that an organocatalyst could mediate the fragmentation of the prochiral cyclopropane 1 with high ee to the easily epimerized product 2. Guofu Zhong of Nanyang Technological University devised (Angew. Chem. Int. Ed. 2009, 48, 6089) a dipolar cycloaddition strategy for the organocatalyzed combination of 3 and 4 with PhNHOH to give the highly substituted cyclopentane 5. Professor Jørgensen also established (Angew. Chem. Int. Ed. 2009, 48, 7338) that conjugate addition of 7 to the prochiral cyclohexenone 6 proceeded with high ee. The initial adduct could be converted into the alkene 8, the alkyne, or the ketone. Wen-Jing Xiao of Central China Normal University, following up on the work of Gong and Cheng, developed (Tetrahedron 2009, 65, 9238) a simple organocatalyst for the desymmetrizing Michael addition of 9 to 10 to give 11 with high de and ee. Control of sidechain chirality is an important aspect of carbocyclic construction. Samuel H. Gellman of the University of Wisconsin demonstrated (J. Am. Chem. Soc. 2009, 131, 16018) that the organocatalyzed addition of 13 to 12 proceeded with high facial selectivity and excellent diastereocontrol. In a complementary approach, Alexander J. A. Cobb of the University of Reading optimized (J. Am. Chem. Soc. 2009, 131, 16016) an organocatalyst for the cyclization of 15 to 16, again with high facial selectivity and excellent diastereocontrol. Ying-Chun Chen of the West China School of Pharmacy established (Organic Lett. 2009, 11, 4660) conditions for the organocatalyzed combination of 17 with 18 to give 19. In a related approach, Bor-Cherng Hong of the National Chung Cheng University showed (Organic Lett. 2009, 11, 5246) that 20, 21, and 22 could be combined under organocatalysis to give 23 in high ee with excellent diastereocontrol. Both of these approaches, and several others that have been published recently, were carried out with aryl substituents. It remains to be seen whether alkyl substituents, which would be more useful in a target-directed synthesis, would be compatible with these methods for ring construction.
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Liu, Hong, Chang-Lin Feng, Xiao-Qing Xie, Wuying Lin, Zheng-Hai Deng, Xin-Lian Wei, Shi-Yong Liu e Yi-Bo Luo. "12. Impacts of Extreme Weather Spells on Flowering Phenology of Wild Orchids in Guangxi, Southwestern China - Hong Liu, Chang-Lin Feng, Xiao-Qing Xie, Wuying Lin, Zheng-Hai Deng, Xin-Lian Wei, Shi-Yong Liu, and Yi-Bo Luo". In Darwin's Orchids, 311–28. University of Chicago Press, 2014. http://dx.doi.org/10.7208/chicago/9780226173641.003.0012.

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YIZI, CHEN, WANG XIAOQIANG e COLLEAGUES. "Reform: Results and Lessons from the 1985 CESRRI Survey11This Report was presented to the State Council in October, 1985. The organization, research, and drafting of the report involved Chen Yizi, Wang Xiaoqiang, Zhang Gang, Zhang Shaojie, Diao Xinsheng, Li Jun, Gai Nangfeng, Jiang Sidong, Xia Xiaojing, Jiang Yao, Ji Xiaoming, Xu Siaobo, Xu Gang, Cao Yuanzheng, Zhao Yujiang, Shen Hong, Liu He, and others. The full version of the report was published in Chinese in 1986, and will be published in English in 1987 under the title, Reform: Challenges and Choices." In Chinese Economic Reform, 172–88. Elsevier, 1988. http://dx.doi.org/10.1016/b978-0-12-587045-0.50016-2.

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