Letteratura scientifica selezionata sul tema "Chemistry, bioinorganic"
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Articoli di riviste sul tema "Chemistry, bioinorganic"
Vilar, Ramon. "Bioinorganic chemistry". Annual Reports Section "A" (Inorganic Chemistry) 105 (2009): 477. http://dx.doi.org/10.1039/b818285j.
Testo completoMcMaster, J. "Bioinorganic chemistry". Annual Reports Section "A" (Inorganic Chemistry) 102 (2006): 564. http://dx.doi.org/10.1039/b514851k.
Testo completoQue, Lawrence, e Lucia Banci. "Bioinorganic chemistry". Current Opinion in Chemical Biology 6, n. 2 (aprile 2002): 169–70. http://dx.doi.org/10.1016/s1367-5931(02)00316-2.
Testo completoBroderick, J. "Bioinorganic chemistry". Current Opinion in Chemical Biology 7, n. 2 (aprile 2003): 157–59. http://dx.doi.org/10.1016/s1367-5931(03)00030-9.
Testo completoBrauman, J. "Bioinorganic chemistry". Science 261, n. 5122 (6 agosto 1993): 663. http://dx.doi.org/10.1126/science.8342030.
Testo completoSola, Marco. "Bioinorganic chemistry". Inorganica Chimica Acta 230, n. 1-2 (marzo 1995): 253–54. http://dx.doi.org/10.1016/0020-1693(95)90533-2.
Testo completoRaven, Emma, Nicholas E. Le Brun, Jonathan McMaster, Jan Reedijk e Nigel J. Robinson. "Bioinorganic chemistry". Dalton Transactions 42, n. 9 (2013): 3027. http://dx.doi.org/10.1039/c2dt90214a.
Testo completoBerg, Jeremy M., e Stephen J. Lippard. "Bioinorganic chemistry". Current Opinion in Chemical Biology 8, n. 2 (aprile 2004): 160–61. http://dx.doi.org/10.1016/j.cbpa.2004.02.014.
Testo completoTheil, Elizabeth C., e H. Holden Thorp. "Bioinorganic chemistry". Current Opinion in Chemical Biology 9, n. 2 (aprile 2005): 95–96. http://dx.doi.org/10.1016/j.cbpa.2005.02.016.
Testo completoRosenzweig, Amy C., e David M. Dooley. "Bioinorganic chemistry". Current Opinion in Chemical Biology 10, n. 2 (aprile 2006): 89–90. http://dx.doi.org/10.1016/j.cbpa.2006.02.036.
Testo completoTesi sul tema "Chemistry, bioinorganic"
Brophy, Megan Brunjes. "Bioinorganic Chemistry of the Human Host-Defense Protein Calprotectin". Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98823.
Testo completoVita. Cataloged from PDF version of thesis.
Includes bibliographical references.
The human innate immune system responds to bacterial and fungal pathogens by releasing the metal-chelating protein calprotectin (CP) at sites of infection and in the upper layers of the epidermis. CP is a Mn(II)- and Zn(ll)-binding protein. The work described in this thesis elucidates the metal-binding properties of CP, and correlates these properties with in vitro growth inhibition of bacteria and fungi. We report that the metal-binding properties of CP are modulated by Ca(ll), and we propose a working model in which CP responds to physiological Ca(Il)-ion gradients to become a potent Zn(ll)- and Mn(Il)-chelating agent in the extracellular space. Individual chapter summaries follow. Chapter 1: Bioinorganic Chemistry of the Host Pathogen Interaction. Transition metal ions are required for all forms of life. During the course of infection, pathogenic microorganisms must acquire transition metals from the host. Three metals of interest from this standpoint are iron, zinc, and manganese. This chapter describes bacterial metal-ion homeostasis machineries, and metal-requiring processes with a focus on Zn(II) and Mn(II). This chapter then highlights the S100 family of Ca(ll)-binding proteins and discuses the Zn(Il)-, Cu(ll)-, and Mn(Il)-binding properties of S100B, S100A12, S100A7, S10OA15, and S100A8/S100A9. Finally, an overview of the scope of this thesis is presented. Chapter 2: Calcium Ion Gradients Modulate the Zinc(Il) Affinity and Antibacterial Activity of Human Calprotectin. Calprotectin (CP) is a human neutrophil protein that is produced and released by neutrophils at sites of infection, where it prevents the growth of microorganisms by sequestering bioavailable zinc(II) and manganese(II). In this chapter, we present metalbinding studies to elucidate the Zn(ll)-binding properties of CP. We report unique optical absorption and EPR spectroscopic signatures for the interfacial His 3Asp and His 4 sites of human CP by using Co(II) as a spectroscopic probe. Zinc competition titrations employing colorimetric and fluorimetric Zn(II) sensors establish that CP coordinates two Zn(II) ions / CP heterodimer. The Ca(ll)-insensitive Zn(ll) sensor ZP4 is used to determine the Kd of CP for Zn(II) in Ca(Il)-deplete and Ca(Il)-replete conditions. These competition titrations afford apparent Kdsitel = 133 58 pM and Kdsite2 = 185 219 nM in the absence of Ca(II). In the presence of excess Ca(Il) these values decrease to Kd,sitel 5 10 pM and Kd,site2 : 240 pM. In vitro antibacterial assays indicate that the metal-binding sites and Ca(ll)-replete conditions are required to inhibit the growth of Gram-negative and Gram-positive bacteria. We propose a model in which Ca(II) ion gradients modulate the antibacterial activity and Zn(Il)-binding properties of human CP. Chapter 3: High-Affinity Manganese Coordination by Human Calprotectin Is Calcium- Dependent and Requires the Histidine-Rich Site at the Dimer Interface. In this chapter, we report that the His 4 motif at the S10OA8/S100A9 dimer interface of CP is required for high-affinity Mn(II) coordination. We identify a low-temperature EPR spectroscopic signal for this site that is consistent with high-spin Mn(II) in an octahedral coordination sphere. This site could be simulated with zero-field splitting parameters D = 270 MHz and EID = 0.30 (E = 81 MHz). This analysis, combined with studies of mutant proteins, suggests that (A8)Hisl7, (A8)His27, (A9)His9l, (A9)His95 and two as-yet unidentified ligands coordinate Mn(ll) at site 2. These studies support a model in which CP responds to Ca(ll) ion gradients to become a potent metal-ion chelator in the extracellular space. Chapter 4: Contributions of the C-terminal Tail of S100A9 to High-Affinity Manganese Binding by Human Calprotectin. This chapter examines the role of the S100A9 C-terminal tail to high-affinity Mn(ll) coordination by human CP. We present a 16-member mutant family with mutations in the S100A9 C-terminal tail (residues 96-114), which houses three histidine and four acidic residues, to evaluate its contribution to Mn(ll) sequestration. These studies confirm that two His residues at positions 103 and 105 complete the octahedral coordination sphere of CP in solution. Appendix 1: Sequence Alignments of Transition-Metal Binding S100 Proteins. Sequence alignments of S100A7, S100A8, S100A9, S100A12, S100A15, and S100B proteins from multiple organisms are presented. Appendix 2: Characterization of CP Mutant Proteins by Circular Dichroism and Analytical Size Exclusion Chromatography. Additional characterization of CP and mutant proteins employed in Chapters 2-4 is presented. Appendix 3: Structures of Sensors Used In this Work. The structures of Zincon, MagFura-2, Zinpyr-1, and Zinpyr-4 are presented. Appendix 4: Manganese Binding Properties of Human Calprotectin under Conditions of High and Low Calcium. This appendix represents a collaborative work with the Drennan Lab (MIT) and Britt Lab (UC Davis) to study the Mn(Il)-CP complex in low- and high-Ca(II) conditions. We report a crystal structure of Mn(Il)-, Ca(Il)-, and Na(l)-bound CP with Mn(II) exclusively coordinated to the His6 motif. Electron spin-echo envelope modulation and electron-nuclear double resonance experiments demonstrate that the six coordinating histidine residues are spectroscopically equivalent. The observed 15N ( = %/h)y perfine couplings (A) arise from two distinct classes of nitrogen atoms: the coordinating E-nitrogen of the imidazole ring of each histidine (A = [3.45, 3.71, 5.91] MHz) and the distal 6-nitrogen (A = [0.11, 0.18, 0.42] MHz). In the absence of Ca(II), the affinity of CP for Mn(II) drops by two to three orders of magnitude, and Mn(II) coordinates to the His6 site as well as other sites on the protein.
by Megan Brunjes Brophy.
Ph. D. in Biological Chemistry
Yan, Siu-cheong. "Bioinorganic chemistry of antimony : interaction of antimonial with biomolecules /". View the Table of Contents & Abstract, 2004. http://sunzi.lib.hku.hk/hkuto/record/B30575540.
Testo completoSeifert, S., e J. Van Den Hoff. "Annual Report 2004 - Institute of Bioinorganic and Radiopharmaceutical Chemistry". Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-28695.
Testo completoSeifert, S., e H. Spies. "Annual Report 2003 - Institute of Bioinorganic and Radiopharmaceutical chemistry". Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-28959.
Testo completoJohannsen, Bernd, e Sepp Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 2002". Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-29271.
Testo completoJohannsen, Bernd, e Sepp Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 2001". Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-29488.
Testo completoSeifert, Sepp, e Bernd Johannsen. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 2000". Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-29716.
Testo completoJohannsen, Bernd, e Sepp Seifert. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1997". Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-30891.
Testo completoSeifert, Sepp, e Bernd Johannsen. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1996". Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-31238.
Testo completoSeifert, Sepp, e Bernd Johannsen. "Institute of Bioinorganic and Radiopharmaceutical Chemistry; Annual Report 1995". Forschungszentrum Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-31653.
Testo completoLibri sul tema "Chemistry, bioinorganic"
Long, Eric C., e Michael J. Baldwin, a cura di. Bioinorganic Chemistry. Washington, DC: American Chemical Society, 2009. http://dx.doi.org/10.1021/bk-2009-1012.
Testo completoKessissoglou, Dimitris P., a cura di. Bioinorganic Chemistry. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0255-1.
Testo completoA, Armstrong Fraser, a cura di. Bioinorganic chemistry. Berlin: Springer-Verlag, 1990.
Cerca il testo completoIvano, Bertini, a cura di. Bioinorganic chemistry. Mill Valley, Calif: University Science Books, 1994.
Cerca il testo completoIvano, Bertini, a cura di. Bioinorganic chemistry. Berlin: Springer-Verlag, 1995.
Cerca il testo completo1953-, Bill E., a cura di. Bioinorganic chemistry. Berlin: Springer-Verlag, 1991.
Cerca il testo completoPhilip, Aisen, a cura di. Bioinorganic chemistry. Berlin: Springer-Verlag, 1988.
Cerca il testo completoB, Goodenough J., Ibers J. A, Jørgensen C. K, Mingos D. M. P, Neilands J. B, Palmer G. A, Reinen D, Sadler P. J, Weiss Ronald 1937- e Williams R. J. P, a cura di. Bioinorganic Chemistry. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988.
Cerca il testo completoAlessio, Enzo, a cura di. Bioinorganic Medicinal Chemistry. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527633104.
Testo completoThorp, H. Holden, e Vincent L. Pecoraro, a cura di. Mechanistic Bioinorganic Chemistry. Washington, DC: American Chemical Society, 1996. http://dx.doi.org/10.1021/ba-1995-0246.
Testo completoCapitoli di libri sul tema "Chemistry, bioinorganic"
Roat-Malone, Rosette. "Bioinorganic Chemistry". In Molecular Life Sciences, 1–29. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-6436-5_407-3.
Testo completoRoat-Malone, Rosette. "Bioinorganic Chemistry". In Molecular Life Sciences, 47–72. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4614-1531-2_407.
Testo completoWeber, Birgit. "Bioinorganic Chemistry". In Coordination Chemistry, 215–37. Berlin, Heidelberg: Springer Berlin Heidelberg, 2023. http://dx.doi.org/10.1007/978-3-662-66441-4_12.
Testo completoJordan, Robert B. "Bioinorganic Chemistry". In Principles of Inorganic Chemistry, 823–52. Cham: Springer International Publishing, 2024. http://dx.doi.org/10.1007/978-3-031-22926-8_19.
Testo completoKüpper, Frithjof C., e Peter M. H. Kroneck. "Iodine Bioinorganic Chemistry". In Iodine Chemistry and Applications, 555–89. Hoboken, NJ: John Wiley & Sons, Inc, 2014. http://dx.doi.org/10.1002/9781118909911.ch32.
Testo completoLippard, Stephen J. "Methane Monooxygenase". In Bioinorganic Chemistry, 1–12. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0255-1_1.
Testo completoMorgenstern-Badarau, Irene. "Magnetic and EPR Studies of Superoxide Dismutases (SOD): Electronic Structure of the Active Sites for the (Copper-Zinc)SOD, its Cobalt Substituted Derivative and the Iron(III)SOD from E. Coli". In Bioinorganic Chemistry, 105–11. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0255-1_10.
Testo completoHadjiliadis, N., K. Dodi e M. Louloudi. "Mechanism of Action of Thiamin Enzymes Role of Metal Ions". In Bioinorganic Chemistry, 113–28. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0255-1_11.
Testo completoLippard, Stephen J. "Platinum Anticancer Drugs". In Bioinorganic Chemistry, 131–40. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0255-1_12.
Testo completoSletten, Einar, e Nils Ăge Frøystein. "NMR Spectroscopic Structure Determination of Metal Ion — Oligonucleotide Complexes — The Results of Sequence-Selective Binding Studies". In Bioinorganic Chemistry, 141–53. Dordrecht: Springer Netherlands, 1995. http://dx.doi.org/10.1007/978-94-011-0255-1_13.
Testo completoAtti di convegni sul tema "Chemistry, bioinorganic"
Glass, Jennifer. "Planetary Metabolism: Linking Solid Interiors to Gaseous Biosignatures via Bioinorganic Chemistry". In Goldschmidt2021. France: European Association of Geochemistry, 2021. http://dx.doi.org/10.7185/gold2021.6279.
Testo completoBren, Kara. "2023 Metals in Biology Gordon Research Conference and Bioinorganic Chemistry Gordon Research Seminar". In The 2023 Metals in Biology Gordon Research Conference and Bioinorganic Chemistry Gordon Research Seminar took place at the Four Points Sheraton / Holiday Inn Express in Ventura, California from January 20-27, 2023. US DOE, 2023. http://dx.doi.org/10.2172/1973842.
Testo completoRapporti di organizzazioni sul tema "Chemistry, bioinorganic"
Raymond, Kenneth N. Marine Bioinorganic Chemistry Workshop Held in Heron Island on 28 June - 2nd July 1989. Fort Belvoir, VA: Defense Technical Information Center, febbraio 1990. http://dx.doi.org/10.21236/ada218348.
Testo completoDrury, Owen Byron. Development of High Resolution X-Ray spectrometers for the Investigation of Bioinorganic Chemistry in Metalloproteins. Office of Scientific and Technical Information (OSTI), gennaio 2007. http://dx.doi.org/10.2172/957593.
Testo completo