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Articoli di riviste sul tema "Chemical affinity"

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Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 29 luglio 2024

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1

Košíková, Božena, Elena Sláviková e Juraj Lábaj. "Affinity of lignin preparations towards genotoxic compounds". BioResources 4, n. 1 (17 novembre 2008): 72–79. http://dx.doi.org/10.15376/biores.4.1.72-79.

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The carcinogenicity and mutagenicity of chemicals may be modulated by other chemicals, including those prepared by organic synthesis. Considering the several drawbacks of synthetic compounds vis-a-vis the human organism, the lignin biomass component was examined for this purpose. The binding affinity of lignin samples prepared by chemical and biological modification of lignin products derived from chemical wood treatment towards for N-nitrosodiethylamine (NDA) was examined. The protective role of the lignin samples against carcinogenesis was tested on a well-known model carcinogen, N-methyl-N´-nitro-N-nitrosoguanidine (MNNG). The observed ability of a series of lignin preparations to reduce alkylation damage of deoxyribonucleic acid (DNA) on hamster cells in vitro could be explained by their affinity to bind N-nitrosoamines. The results indicate that lignin has potential to protect living organisms against damaging effects of different genotoxicants.

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2

Kauvar, Lawrence M., Hugo O. Villar, J. Richard Sportsman, Deborah L. Higgins e Donald E. Schmidt. "Protein affinity map of chemical space". Journal of Chromatography B: Biomedical Sciences and Applications 715, n. 1 (settembre 1998): 93–102. http://dx.doi.org/10.1016/s0378-4347(98)00045-0.

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3

PARIKH, INDU, e PEDRO CUATRECASAS. "AFFINITY CHROMATOGRAPHY". Chemical & Engineering News 63, n. 34 (26 agosto 1985): 17–32. http://dx.doi.org/10.1021/cen-v063n034.p017.

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4

Ohno, K., Y. Inoue e M. Sakurai. "Quantum Chemical Study of Antibody Affinity Maturation". Seibutsu Butsuri 43, supplement (2003): S50. http://dx.doi.org/10.2142/biophys.43.s50_4.

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5

Alcantara, R. E., C. Xu, T. G. Spiro e V. Guallar. "A quantum-chemical picture of hemoglobin affinity". Proceedings of the National Academy of Sciences 104, n. 47 (14 novembre 2007): 18451–55. http://dx.doi.org/10.1073/pnas.0706026104.

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6

Hornung, M. W., M. A. Tapper, J. S. Denny, R. C. Kolanczyk, B. R. Sheedy, P. C. Hartig, H. Aladjov, T. R. Henry e P. K. Schmieder. "Effects-based chemical category approach for prioritization of low affinity estrogenic chemicals". SAR and QSAR in Environmental Research 25, n. 4 (3 aprile 2014): 289–323. http://dx.doi.org/10.1080/1062936x.2014.898692.

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7

Schmieder, P., Ovanes Mekenyan, Steven Bradbury e G. Veith. "QSAR prioritization of chemical inventories for endocrine disruptor testing". Pure and Applied Chemistry 75, n. 11-12 (1 gennaio 2003): 2389–96. http://dx.doi.org/10.1351/pac200375112389.

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Binding affinity between chemicals and the estrogen receptor (ER) serves as an indicator of the potential to cause endocrine disruption through this receptor-mediated endocrine pathway. Estimating ER-binding affinity is, therefore, one strategic approach to reducing the costs of screening chemicals for potential risks of endocrine disruption. While measuring ER binding with in vitro assays may be the first choice in prioritizing chemicals for additional in vitro or in vivo estrogenicity testing, the time and costs associated with screening thousands of chemicals is prohibitive. Recent advances in 3D modeling of the reactivity of flexible structures make in silico methods for estimating ER binding possible. One technique, the common reactivity pattern (COREPA) approach, was applied to development of reactivity patterns for ER relative binding affinity based on global nucleophilicity, interatomic distances between nucleophilic sites, and local electron donor capability of the nucleophilic sites. The reactivity patterns provided descriptor profiles for order-of-magnitude RBA ranges of training set chemicals. An exploratory expert system was subsequently developed to predict RBA and rank chemicals with respect to potential estrogenicity. A strategy is presented for extending initial exploratory 3D QSAR models beyond current training sets to increase applicability to more diverse structures in large chemical inventories.

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8

Freidin, A. B. "On the chemical affinity tensor for chemical reactions in deformable materials". Mechanics of Solids 50, n. 3 (maggio 2015): 260–85. http://dx.doi.org/10.3103/s0025654415030048.

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9

Nayarisseri, Anuraj. "Experimental and Computational Approaches to Improve Binding Affinity in Chemical Biology and Drug Discovery". Current Topics in Medicinal Chemistry 20, n. 19 (14 settembre 2020): 1651–60. http://dx.doi.org/10.2174/156802662019200701164759.

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Drug discovery is one of the most complicated processes and establishment of a single drug may require multidisciplinary attempts to design efficient and commercially viable drugs. The main purpose of drug design is to identify a chemical compound or inhibitor that can bind to an active site of a specific cavity on a target protein. The traditional drug design methods involved various experimental based approaches including random screening of chemicals found in nature or can be synthesized directly in chemical laboratories. Except for the long cycle design and time, high cost is also the major issue of concern. Modernized computer-based algorithm including structure-based drug design has accelerated the drug design and discovery process adequately. Surprisingly from the past decade remarkable progress has been made concerned with all area of drug design and discovery. CADD (Computer Aided Drug Designing) based tools shorten the conventional cycle size and also generate chemically more stable and worthy compounds and hence reduce the drug discovery cost. This special edition of editorial comprises the combination of seven research and review articles set emphasis especially on the computational approaches along with the experimental approaches using a chemical synthesizing for the binding affinity in chemical biology and discovery as a salient used in de-novo drug designing. This set of articles exfoliates the role that systems biology and the evaluation of ligand affinity in drug design and discovery for the future.

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10

Nowak, Damian, Rafał Adam Bachorz e Marcin Hoffmann. "Neural Networks in the Design of Molecules with Affinity to Selected Protein Domains". International Journal of Molecular Sciences 24, n. 2 (16 gennaio 2023): 1762. http://dx.doi.org/10.3390/ijms24021762.

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Drug design with machine learning support can speed up new drug discoveries. While current databases of known compounds are smaller in magnitude (approximately 108), the number of small drug-like molecules is estimated to be between 1023 and 1060. The use of molecular docking algorithms can help in new drug development by sieving out the worst drug-receptor complexes. New chemical spaces can be efficiently searched with the application of artificial intelligence. From that, new structures can be proposed. The research proposed aims to create new chemical structures supported by a deep neural network that will possess an affinity to the selected protein domains. Transferring chemical structures into SELFIES codes helped us pass chemical information to a neural network. On the basis of vectorized SELFIES, new chemical structures can be created. With the use of the created neural network, novel compounds that are chemically sensible can be generated. Newly created chemical structures are sieved by the quantitative estimation of the drug-likeness descriptor, Lipinski’s rule of 5, and the synthetic Bayesian accessibility classifier score. The affinity to selected protein domains was verified with the use of the AutoDock tool. As per the results, we obtained the structures that possess an affinity to the selected protein domains, namely PDB IDs 7NPC, 7NP5, and 7KXD.

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11

Koike, A. "Comparison of methods for chemical-compound affinity prediction". SAR and QSAR in Environmental Research 17, n. 5 (ottobre 2006): 497–514. http://dx.doi.org/10.1080/10629360600934168.

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12

Torres Castillo, C. S., C. Bruel e J. R. Tavares. "Chemical affinity and dispersibility of boron nitride nanotubes". Nanoscale Advances 2, n. 6 (2020): 2497–506. http://dx.doi.org/10.1039/d0na00136h.

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The chemical affinity of purified boron nitride nanotubes (BNNTs) is measured in terms of Hansen solubility parameters, taking into account relative sedimentation time in various solvents. This improves predictions for the dispersion of BNNTs.

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13

Albrow, Victoria E., Carla Fernandes, David M. Beal, Matthew D. Selby, Mireia Fernandez-Ocaña, Klaus C. Rumpel e Lyn H. Jones. "Quantitative affinity-based chemical proteomics of TrkA inhibitors". Med. Chem. Commun. 3, n. 3 (2012): 322–25. http://dx.doi.org/10.1039/c2md00271j.

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14

Saikhanov, M. B. "Chemical Affinity and the Density of Energy Levels". Journal of Modern Physics 06, n. 11 (2015): 1452–55. http://dx.doi.org/10.4236/jmp.2015.611149.

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15

Freidin, Alexander B., Igor K. Korolev, Sergey P. Aleshchenko e Elena N. Vilchevskaya. "Chemical affinity tensor and chemical reaction front propagation: theory and FE-simulations". International Journal of Fracture 202, n. 2 (26 ottobre 2016): 245–59. http://dx.doi.org/10.1007/s10704-016-0155-1.

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16

Míka, V., V. Kubáň, B. Klejdus, V. Odstrčilová e P. Nerušil. "Phenolic compounds as chemical markers of low taxonomic levels in the family Poaceae". Plant, Soil and Environment 51, No. 11 (20 novembre 2011): 506–12. http://dx.doi.org/10.17221/3624-pse.

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The spectra of non-structural phenolics in herbage were used to study genetic affinity in polyploid complex of Dactylis L., next in complex of octoploid brome species, and in red fescue cultivar collection. The diploid (2n = 14) subspecies of Dactylis revealed distinct differences from the tetraploid (2n = 28) ones as a clearly specialized group. In the genus Bromus the affinity bounds of the species inside the section (e.g. Ceratochloa) were not very tight in comparison to those between the species from various sections. Also remarkable differences in affinity bonds among red fescue cultivars were determined. Although the conclusions are only based on the results from one year and two sites, they bring significant information on exploitation of phenolic compounds. They demonstrate that phenolic profiles could be used in chemical taxonomy of grasses also at low taxonomic levels as a useful marker. As they are environmentally not as stable as the markers of primary metabolism, plant material for analyses should be standardized as to growing condition, growth stages of plants etc.

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17

Salas-Banuet, Guillermo, José Ramírez-Vieyra, Oscar Jaime Restrepo Baena, María Noguez-Amaya e Bryan Cockrell. "The importance of being chemical affinity. Part VI: The harvest". DYNA 82, n. 190 (11 maggio 2015): 13–22. http://dx.doi.org/10.15446/dyna.v82n190.48730.

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The quantitative scale of electronegativity, obtained by Linus Pauling, as a result of qualitative electron affinity background, generated multiple different and interesting proposals until today, which have proved to be the effort of ingenuity to get a universal concept of affinity, which has resulted incomplete. Thermodynamics, specifically its thermochemical branch, has offered an explanation, which has been accepted by The International Union of Pure and Applied Chemistry (IUPAC), as incomplete as the former. In both cases, it is thought that the error is in regard to affinity as a property, rather than a behavior.

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18

Bzowej, Natalie H., Hyman B. Niznik e Philip Seeman. "Dopamine D1 receptors with enhanced agonist affinity and reduced antagonist affinity revealed by chemical modification". Biochemical and Biophysical Research Communications 152, n. 2 (aprile 1988): 933–39. http://dx.doi.org/10.1016/s0006-291x(88)80130-x.

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19

Sharma, Chiranjeev, Dickson Donu, Alyson M. Curry, Elizabeth Barton e Yana Cen. "Multifunctional activity-based chemical probes for sirtuins". RSC Advances 13, n. 17 (2023): 11771–81. http://dx.doi.org/10.1039/d3ra02133e.

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20

Zou, Xiangman, Zhi Liu, Liya Liu, Wei Shi, Wanzhen Li, Zifen Guo, Feng Tang e Wei Huang. "Enhanced transglycosylation activity of an Endo-F3 mutant by ligand-directed localization". Organic & Biomolecular Chemistry 20, n. 15 (2022): 3086–95. http://dx.doi.org/10.1039/d2ob00030j.

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Proximity-directed Endo-F3 D165A was developed by chemically arming with an Fc affinity tag, which exhibited excellent transglycosylation activities towards IgG, indicating a promising strategy for enzyme activity enhancement by chemical tools.

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21

Pachl, Fiona, Patrik Plattner, Benjamin Ruprecht, Guillaume Médard, Norbert Sewald e Bernhard Kuster. "Characterization of a Chemical Affinity Probe Targeting Akt Kinases". Journal of Proteome Research 12, n. 8 (3 luglio 2013): 3792–800. http://dx.doi.org/10.1021/pr400455j.

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22

Matsuno, Koichiro, e Stanley N. Salthe. "Chemical Affinity as Material Agency for Naturalizing Contextual Meaning". Information 3, n. 1 (16 gennaio 2012): 21–35. http://dx.doi.org/10.3390/info3010021.

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23

Iliuk, Anton, Xiaofeng Wu, Li Li, Jie Sun, Marco Hadisurya, Ronald S. Boris e W. Andy Tao. "Plasma-Derived Extracellular Vesicle Phosphoproteomics through Chemical Affinity Purification". Journal of Proteome Research 19, n. 7 (12 maggio 2020): 2563–74. http://dx.doi.org/10.1021/acs.jproteome.0c00151.

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24

Kuznik, G., B. Hörsch, G. Kretzschmar e C. Unverzagt. "Chemical and enzymatic synthesis of high-affinity selectin ligands". Bioorganic & Medicinal Chemistry Letters 7, n. 5 (marzo 1997): 577–80. http://dx.doi.org/10.1016/s0960-894x(97)00051-6.

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25

Tomioka, Kanji, Hideki Fukuda e Hiroshi Taniguchi. "Insulin delivery system based on an affinity chemical valve". Journal of Fermentation and Bioengineering 77, n. 4 (gennaio 1994): 442–44. http://dx.doi.org/10.1016/0922-338x(94)90022-1.

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26

Mulhollan, G. A., e J. C. Bierman. "Enhanced chemical immunity for negative electron affinity GaAs photoemitters". Journal of Vacuum Science & Technology A: Vacuum, Surfaces, and Films 26, n. 5 (settembre 2008): 1195–97. http://dx.doi.org/10.1116/1.2965816.

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27

Soraya, hiva, Ruohollah Seddigh, Fatemeh Hadi e Mohammad Faramarzi. "Chemical cannabis; The New Trend of addiction in Iran". Iranian Journal of Psychiatry and Clinical Psychology 28, n. 1 (20 aprile 2022): 10. http://dx.doi.org/10.32598/ijpcp.28.1.4010.1.

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Synthetic cannabinoids (SC) are a heterogeneous group of substances with a high affinity for cannabinoid receptors. Unlike Δ9-tetrahydrocannabinol (THC), synthetic cannabinoids are incredibly potent, highly productive, have more affinity for the Cannabinoid receptor type 1 (CB1), and Cannabinoid receptor type 2 (CB2), and are designed to accelerate the effects of tetrahydrocannabinol. Also, there is experimental evidence that SCs acts on non-cannabinoid receptors, such as the 5-HT2B receptor or dopaminergic receptors. (1, 2).

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28

Gabler, Anna Maria, Annalena Ludwig, Florian Biener, Magdalena Waldner, Corinna Dawid e Oliver Frank. "Chemical Characterization of Red Wine Polymers and Their Interaction Affinity with Odorants". Foods 13, n. 4 (8 febbraio 2024): 526. http://dx.doi.org/10.3390/foods13040526.

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In order to characterize red wine polymers with regard to their binding properties to aroma compounds (odorants), a qualitative and quantitative analysis of chemical degradation products after different chemical treatments (thiolytic, acidic, and alkaline depolymerization) of high -molecular-weight (HMW) fractions of red wine was performed. Using 1H NMR, LC-ToF-MS, LCMS/MS, and HPIC revealed key structural features such as carbohydrates, organic acids, phenolic compounds, anthocyanins, anthocyanidins, amino acids, and flavan-3-ols responsible for odorant-polymer interactions. Further, NMR-based interaction studies of the selected aroma compounds 3methylbutanol, cis-whisky lactone, 3-methylbutanoic acid, and 3-isobutyl-2-methoxypyrazine with HMW polymers after chemical treatment demonstrated a reduced interaction affinity of the polymer compared to the native HMW fractions, and further, the importance of aromatic compounds such as flavan-3-ols for the formation of odorant polymer interactions. In addition, these observations could be verified by human sensory experiments. For the first time, the combination of a compositional analysis of red wine polymers and NMR-based interaction studies with chemically treated HMW fractions enabled the direct analysis of the correlation of the polymer’s structure and its interaction affinity with key odorants in red wine.

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Pratama, Mohammad Rizki Fadhil, e Sutomo S. "CHEMICAL STRUCTURE OPTIMIZATION OF LUPEOL AS ER-Α AND HER2 INHIBITOR". Asian Journal of Pharmaceutical and Clinical Research 11, n. 6 (7 giugno 2018): 298. http://dx.doi.org/10.22159/ajpcr.2018.v11i6.24226.

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Objectives: Lupeol, a triterpenoid isolated from Kasturi (Mangifera casturi) fruit has been known for having several pharmacological activities, including anticancer properties. Lupeol showed antiproliferative activity toward many cancer cells line including breast cancer. Lupeol showed promising potency as both ER-α and HER2 inhibitors, although still lower than known ER-α and HER2 Inhibitors. Chemical structure optimization of lupeol was predicted could increase the affinity of lupeol derivatives against ER-α and HER2. This study aims to determine lupeol derivative with the highest affinity against ER-α and HER2.Methods: All ligands were sketched and optimized using Gaussian 03W with Hartree–Fock method basis set 3-21G. Molecular docking was performed using Autodock 4.2.6 on several modified chemical structure of lupeol against active site of ER-α and HER2. The main parameter used was the free energy of binding and inhibition constants as affinity marker.Results: The docking results show that lupeol derivative with an amine group (Lupeol-2) and ethyl group (Lupeol-4) at position C3 provide the highest affinity with the free energy of binding and dissociation constant −12.24 kcal/mol and 1.07 nM for ER-α also −9.63 kcal/mol and 86.94 nM for HER2, respectively. Interestingly, although lupeol derivatives showed higher affinity toward ER-α, their amino acid residues were closer to the interaction on HER2.Conclusion: These results predict that lupeol have greater potential to be developed as a HER2 inhibitor. Further, derivate lupeol-4 should be potential to be developed as HER2-positive breast cancer therapy.

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Vodyanitskii, Yuri, e Dmitry Vlasov. "Integrated Assessment of Affinity to Chemical Fractions and Environmental Pollution with Heavy Metals: A New Approach Based on Sequential Extraction Results". International Journal of Environmental Research and Public Health 18, n. 16 (10 agosto 2021): 8458. http://dx.doi.org/10.3390/ijerph18168458.

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To assess the affinity degree of heavy metals (HMs) to geochemical phases, many indices with several limitations are used. Thus, this study aims to develop a new complex index for assessing contamination level and affinity to chemical fractions in various solid environmental media. For this, a new integrated approach using the chemical affinity index (CAF) is proposed. Comparison of CAF with %F on the literature examples on fractionation of HMs from soils, bottom sediments, atmospheric PM10, and various particle size fractions of road dust proved a less significant role of the residual HMs fraction and a greater contribution of the rest of the chemical fractions in the pollution of all studied environments. This fact is due to the normalization relative to the global geochemical reference standard, calculations of contribution of an individual element to the total pollution by all studied HMs, and contribution of the particular chemical fraction to the total HMs content taken into account in CAF. The CAF index also shows a more significant role in pollution and chemical affinity of mobile and potentially mobile forms of HMs. The strong point of CAF is the stability of the obtained HM series according to the degree of chemical affinity and contamination. Future empirical studies are necessary for the more precise assessment of CAF taking into account the spatial distribution of HMs content, geographic conditions, geochemical factors, the intensity of anthropogenic impact, environmental parameters (temperature, humidity, precipitation, pH value, the content of organic matter, electrical conductivity, particle size distribution, etc.). The combined use of CAF along with other indices allows a more detailed assessment of the strength of HMs binding to chemical phases, which is crucial for understanding the HMs’ fate in the environment.

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31

Kim (book author), Mi Gyung, e Noel G. Coley (review author). "Affinity, That Elusive Dream: A Genealogy of the Chemical Revolution". Aestimatio: Critical Reviews in the History of Science 2 (21 dicembre 2015): 88–93. http://dx.doi.org/10.33137/aestimatio.v2i0.25747.

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Van Eygen, Gilles, Bart Van der Bruggen, Anita Buekenhoudt e Patricia Luis Alconero. "Efficient membrane-based affinity separations for chemical applications: A review". Chemical Engineering and Processing - Process Intensification 169 (dicembre 2021): 108613. http://dx.doi.org/10.1016/j.cep.2021.108613.

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Salas-Banuet, Guillermo, José Ramírez-Vieyra, Oscar Jaime Restrepo Baena, María Noguez-Amaya e Bryan Cockrell. "The importance of being chemical affinity. Part V: The fruits". DYNA 81, n. 187 (24 ottobre 2014): 267–75. http://dx.doi.org/10.15446/dyna.v81n187.46092.

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Sakata, K., S. Nakajima, Y. Inoue e M. Sakurai. "1D0900 Quantum chemical study on the anion affinity of Halorhodopsin". Seibutsu Butsuri 42, supplement2 (2002): S22. http://dx.doi.org/10.2142/biophys.42.s22_2.

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Zhang, Chunfang, Dale Fredericks, Eva M. Campi, Pas Florio, Christina Jespersgaard, Christine Bruun Schiødt e Milton T. W. Hearn. "Purification of monoclonal antibodies by chemical affinity mixed mode chromatography". Separation and Purification Technology 142 (marzo 2015): 332–39. http://dx.doi.org/10.1016/j.seppur.2015.01.006.

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Urdal, D. L., S. M. Call, J. L. Jackson e S. K. Dower. "Affinity purification and chemical analysis of the interleukin-1 receptor." Journal of Biological Chemistry 263, n. 6 (febbraio 1988): 2870–77. http://dx.doi.org/10.1016/s0021-9258(18)69149-5.

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Ohno, Kazuki, Mitsutoshi Wada, Seiji Saito, Yoshio Inoue e Minoru Sakurai. "Quantum chemical study on the affinity maturation of 48G7 antibody". Journal of Molecular Structure: THEOCHEM 722, n. 1-3 (maggio 2005): 203–11. http://dx.doi.org/10.1016/j.theochem.2004.11.061.

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Gutsev, G. L., e A. I. Boldyrev. "Problem of second and higher electron affinity of chemical compounds". Bulletin of the Academy of Sciences of the USSR Division of Chemical Science 38, n. 7 (luglio 1989): 1541–43. http://dx.doi.org/10.1007/bf00978456.

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Barshop, William D., Hee Jong Kim, Xiaorui Fan, Jihui Sha, Shima Rayatpisheh e James A. Wohlschlegel. "Chemical Derivatization of Affinity Matrices Provides Protection from Tryptic Proteolysis". Journal of Proteome Research 18, n. 10 (9 settembre 2019): 3586–96. http://dx.doi.org/10.1021/acs.jproteome.9b00254.

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Wang, Hangxiang, Yoichiro Koshi, Daishiro Minato, Hiroshi Nonaka, Shigeki Kiyonaka, Yasuo Mori, Shinya Tsukiji e Itaru Hamachi. "Chemical Cell-Surface Receptor Engineering Using Affinity-Guided, Multivalent Organocatalysts". Journal of the American Chemical Society 133, n. 31 (10 agosto 2011): 12220–28. http://dx.doi.org/10.1021/ja204422r.

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41

Bartmess, John E. "Gas-phase equilibrium affinity scales and chemical ionization mass spectrometry". Mass Spectrometry Reviews 8, n. 5 (settembre 1989): 297–343. http://dx.doi.org/10.1002/mas.1280080502.

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42

Lien Thuong, Nguyen Thi. "SCREENING OF PEPTIDE RECEPTOR SEQUENCES FOR AMITROL DETECTION USING CHROMATOGRAPHIC BIOPANNING". Vietnam Journal of Science and Technology 54, n. 2A (19 marzo 2018): 6. http://dx.doi.org/10.15625/2525-2518/54/2a/11903.

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Endocrine disrupting chemicals (EDCs) have been known as health threatening compounds and much attention has been paid in a research related with detection and/or removal from food sources and living environment. Amitrol, classified as one of EDCs, is hard to be detected and removed due to its chemical characteristics such as small molecular weight, low reactivity and high solubility. Some of organic compounds were investigated to find the corresponding binding peptides to those by biopanning protocol. However, peptides with affinity to amitrol remained to be searched for because amitrol is hard to be used as a target of free form or immobilized form in common biopanning protocol. In our experiment, amitrol was successfully immobilized on CDI monolithic column with the presence of catalyst and hence was able to be applied as a target component in biopanning. Chromatic biopanning was carried out as a fast and convenient method for the selection of peptides with high affinity to amitrol. Chemical and physical methods were combined in elution step to improve the selection efficiency for strong binders. After multiple rounds of negative screening and positive screening, high affinity peptide sequences were isolated from initial peptide libraries. Applications of these peptide sequences can be widened from bio adsorption to biosensor for environment pollution control.

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Yang, Bo-Lun, e Shigeo Goto. "Affinity Purification by Tapered Bed." JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 26, n. 6 (1993): 752–54. http://dx.doi.org/10.1252/jcej.26.752.

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Lee, Alpha A., Michael P. Brenner e Lucy J. Colwell. "Predicting protein–ligand affinity with a random matrix framework". Proceedings of the National Academy of Sciences 113, n. 48 (16 novembre 2016): 13564–69. http://dx.doi.org/10.1073/pnas.1611138113.

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Abstract (sommario):

Rapid determination of whether a candidate compound will bind to a particular target receptor remains a stumbling block in drug discovery. We use an approach inspired by random matrix theory to decompose the known ligand set of a target in terms of orthogonal “signals” of salient chemical features, and distinguish these from the much larger set of ligand chemical features that are not relevant for binding to that particular target receptor. After removing the noise caused by finite sampling, we show that the similarity of an unknown ligand to the remaining, cleaned chemical features is a robust predictor of ligand–target affinity, performing as well or better than any algorithm in the published literature. We interpret our algorithm as deriving a model for the binding energy between a target receptor and the set of known ligands, where the underlying binding energy model is related to the classic Ising model in statistical physics.

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Bansal, Rachit, Zehra Elgundi, Andrew Care, Sophia C. Goodchild, Megan S. Lord, Alison Rodger e Anwar Sunna. "Elucidating the Binding Mechanism of a Novel Silica-Binding Peptide". Biomolecules 10, n. 1 (18 dicembre 2019): 4. http://dx.doi.org/10.3390/biom10010004.

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Abstract (sommario):

Linker-protein G (LPG) is a bifunctional fusion protein composed of a solid-binding peptide (SBP, referred as the “linker”) with high affinity to silica-based compounds and a Streptococcus protein G (PG), which binds antibodies. The binding mechanisms of LPG to silica-based materials was studied using different biophysical techniques and compared to that of PG without the linker. LPG displayed high binding affinity to a silica surface (KD = 34.77 ± 11.8 nM), with a vertical orientation, in comparison to parent PG, which exhibited no measurable binding affinity. Incorporation of the linker in the fusion protein, LPG, had no effect on the antibody-binding function of PG, which retained its secondary structure and displayed no alteration of its chemical stability. The LPG system provided a milder, easier, and faster affinity-driven immobilization of antibodies to inorganic surfaces when compared to traditional chemical coupling techniques.

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46

Glad, Cristina, Karin Sjödin e Bo Mattiasson. "Streaming potential—a general affinity sensor". Biosensors 2, n. 2 (gennaio 1986): 89–100. http://dx.doi.org/10.1016/0265-928x(86)80012-8.

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47

Liapis, Athanasios I. "Modelling Affinity Chromatography". Separation and Purification Methods 19, n. 2 (gennaio 1990): 133–210. http://dx.doi.org/10.1080/03602549008050935.

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48

S, Anaghashree, e Chaitra H. "Review of Impact of Dooshi Visha on Female Infertility". International Research Journal of Ayurveda & Yoga 05, n. 10 (2022): 110–17. http://dx.doi.org/10.47223/irjay.2022.51018.

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Abstract (sommario):

Dooshi visha is a unique concept mentioned in Ayurveda, which has the potential to accumulate in various bodily tissues depending on their affinity and harm the body, by causing chronic illness. Present day exposure to various harmful chemicals can be considered as dooshi visha as they get accumulated in bodily tissues leading to cumulative toxicity causing chronic illnesses, instead of causing death immediately. Chemicals acting over the female reproductive system at different doses of exposure, and concept of dooshi visha was studied thoroughly. Chemicals having their affinity towards female reproductive system was found to cause significant harmful effects like infertility when exposed above permissible limit for longer durations, hence it can be considered as dooshi vishas. Incidences of chemical exposure and female infertility is increasing proportionally. Present day female reproductive problems viewed in the perspective of dooshi visha and treating accordingly may subside the present days female reproductive problems. Hence, present paper focuses on impact of dooshi visha on female fertility.

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49

Litovchick, Alexander, Xia Tian, Michael I. Monteiro, Kaitlyn M. Kennedy, Marie-Aude Guié, Paolo Centrella, Ying Zhang, Matthew A. Clark e Anthony D. Keefe. "Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry". Molecules 24, n. 10 (27 maggio 2019): 2026. http://dx.doi.org/10.3390/molecules24102026.

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Abstract (sommario):

Inspired by the many reported successful applications of DNA-encoded chemical libraries in drug discovery projects with protein targets, we decided to apply this platform to nucleic acid targets. We used a 120-billion-compound set of 33 distinct DNA-encoded chemical libraries and affinity-mediated selection to discover binders to a panel of DNA targets. Here, we report the successful discovery of small molecules that specifically interacted with DNA G-quartets, which are stable structural motifs found in G-rich regions of genomic DNA, including in the promoter regions of oncogenes. For this study, we chose the G-quartet sequence found in the c-myc promoter as a primary target. Compounds enriched using affinity-mediated selection against this target demonstrated high-affinity binding and high specificity over DNA sequences not containing G-quartet motifs. These compounds demonstrated a moderate ability to discriminate between different G-quartet motifs and also demonstrated activity in a cell-based assay, suggesting direct target engagement in the cell. DNA-encoded chemical libraries and affinity-mediated selection are uniquely suited to discover binders to targets that have no inherent activity outside of a cellular context, and they may also be of utility in other nucleic acid structural motifs.

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50

Chi, Shu-Chun, Hsing-Cheng Hsi e Chia Ming Chang. "Quantum Chemical GA-MLR, Cluster Model, and Conceptual DFT Descriptors Studies on the Binding Interaction of Estrogen Receptor Alpha with Endocrine Disrupting Chemicals". Crystals 13, n. 2 (27 gennaio 2023): 228. http://dx.doi.org/10.3390/cryst13020228.

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Abstract (sommario):

In the present study, the predication of the binding affinity (log RBA) of estrogen receptor alpha with three categories of environmental endocrine disrupting chemicals (EDCs), namely, PCB, phenol, and DDT, is performed by the quantum chemical genetic algorithm multiple linear regression (GA-MLR) method. The result of the optimal model indicates that log RBA increases with increasing the electrophilicity and hydrophobicity of EDCs. However, by using the quantum chemical cluster model approach, the modeling results reveal that electrostatic interaction and hydrogen bonding play a significant role. The chemical reactivity descriptors calculated based on the conceptual density functional theory also indicate that the binding mechanism of charge-controlled interaction is superior to that of frontier-controlled interaction.

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