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Tesi sul tema "Chemical affinity"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 29 luglio 2024

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1

Lindgren, Joel. "Chemical Engineering of Small Affinity Proteins." Doctoral thesis, KTH, Proteinteknologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-141014.

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Small robust affinity proteins have shown great potential for use in therapy, in vivo diagnostics, and various biotechnological applications. However, the affinity proteins often need to be modified or functionalized to be successful in many of these applications. The use of chemical synthesis for the production of the proteins can allow for site-directed functionalization not achievable by recombinant routes, including incorporation of unnatural building blocks. This thesis focuses on chemical engineering of Affibody molecules and an albumin binding domain (ABD), which both are three-helix bu

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2

Zourna, Kalliopi. "Smart magnetic affinity adsorbents." Thesis, University of Birmingham, 2009. http://etheses.bham.ac.uk//id/eprint/511/.

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As the focus of research on ‘adaptive/responsive’ surfaces has in recent years contributed strongly towards the design of surface materials with ‘intelligent’ or ‘smart’ behaviour, current superparamagnetic adsorbents being employed both in small and large scale operations can be surface modified and improved by gaining dual functionalities. In this work, modification of M-PVA supports with polymer brushes of dual properties has been explored for their intended use in bioseparation technology, i.e. for both selectively protein binding and enhanced temperature elution of especially difficult to

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3

Beard, Hester Annie. "Affinity-guided chemical probes for the study of protein interactions." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/20637/.

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Chemical methods that allow for the targeted labelling of a specific protein within a complex biological environment can enable valuable information regarding the structure and function of proteins to be gained. This thesis explores two different projects where affinity-guided chemical probes were used to study the interactions of proteins, both with small molecules (Chapter 2) and interacting protein partners (Chapter 3). Firstly, chemical labelling methods based on a recognition unit for the protein of interest are reviewed in Chapter 1. Then, Chapter 2 describes how a combination of chemica

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4

Tarasova, Anna Optometry UNSW. "Fabrication and characterisation of affinity-bound liposomes." Awarded by:University of New South Wales. Optometry, 2007. http://handle.unsw.edu.au/1959.4/29114.

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In considering the concept of surface-immobilised liposomes as a drug release system, two factors need to addressed, the interfacial surface density of the liposomes for maximum drug loading and the stability of these liposomes to allow for controlled drug release. This thesis investigates a multilayer system for the affinity immobilisation of liposomes and their stability to various applied stresses. In the work presented here an allylamine monomer was used to create plasma coatings that were stable, thin and amine-rich. The aging studies using AFM showed these films to rapidly oxidise on exp

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5

Zulqarnain, Kamran. "Scale-up of affinity separation based on magnetic support particles." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313426.

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6

Stewart, David Johnston. "Immobilisation of triazine dyes on inert hydrophobic supports for affinity chromatography." Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315974.

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7

Miller, Eric Alexander. "Development of thermostable affinity reagents for low-cost, paper-based medical diagnostics." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122849.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2019<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>The timely diagnosis and treatment of disease in resource-constrained settings requires the development of robust point-of-care (POC) diagnostics, which provide accurate results and can be employed by users with minimal medical training and limited access to basic infrastructure. One of the most common POC diagnostic formats is the immunochromatographic rapid diagnostic test, which traditionally uses nitrocellulose-i

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8

Hsu, Kuang-Hsin. "Scale-up of affinity chromatography for protein purifications." Ohio : Ohio University, 2000. http://www.ohiolink.edu/etd/view.cgi?ohiou1172002240.

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9

Lam, Hei Ning Henry. "Electrostatic and affinity enhancements of protein partitioning in two-phase aqueous micellar systems." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33700.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2005.<br>Includes bibliographical references (p. 175-188).<br>This thesis was motivated by the practical need to develop a scalable and cost-effective separation method for low-cost, high-volume protein products. This unmet challenge can potentially be addressed by extraction in two-phase aqueous micellar systems, in which biomolecules can be partitioned in mild, predominantly aqueous environments. The goal of this thesis was to explore various ways of enhancing protein partitioning in two-phase aqueous mice

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10

Liebenberg, Liesl Eileen. "Non-covalent immobilisation of a ligand system : a new approach to affinity separation." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53522.

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Thesis (MSc)--Stellenbosch University, 2003.<br>ENGLISH ABSTRACT: Advances in pharmacology, biochemistry and biotechnology are increasingly dependant upon affinity chromatography as a preferred separation technique for the purification and characterisation of specific biomolecules. In the past few years avidin-biotin technology has been widely and successfully used in the fields of medicine, pharmacy, biology and biochemistry. The avidin-biotin complex (ABC) has been used as a mediator for affinity chromatography, affinity cytochemistry, immunoassay, histopathology, bioaffinity sensors,

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11

陳磊碩 and Lui-sek Chan. "Chemical modification of immunoglobulins and the effects on antigen binding site affinity." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1993. http://hub.hku.hk/bib/B29913378.

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12

Chan, Lui-sek. "Chemical modification of immunoglobulins and the effects on antigen binding site affinity /." [Hong Kong] : University of Hong Kong, 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13731506.

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13

Heimer, Brandon Walter. "Methylated DNA detection using a high-affinity methyl-CpG binding protein and photopolymerization-based amplification." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/98796.

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Thesis: Sc. D., Massachusetts Institute of Technology, Department of Chemical Engineering, 2015.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 123-132).<br>Methylation at the 5 position of the cytosine base, when followed by guanine (CpG) in the promoter region of a protein-coding gene, is an epigenetic modification that has been shown to be involved in gene silencing. While important for regulating many normal, cellular processes, aberrant DNA methylation has been implicated in the development of human diseases such as cancer. Medical research has begu

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14

Lippow, Shaun Matthew. "Computational analysis, design, and experimental validation of antibody binding affinity improvements beyond in vivo maturation." Thesis, Massachusetts Institute of Technology, 2007. http://hdl.handle.net/1721.1/38886.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2007.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Includes bibliographical references (leaves 98-110).<br>This thesis presents novel methods for the analysis and design of high-affinity protein interactions using a combination of high-resolution structural data and physics-based molecular models. First, computational analysis was used to investigate the molecular basis for the affinity improvement of

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15

Tellez, Rodriguez Carlos Mario 1967. "Studies of metal affinity interactions in metal recovery and bioremediation." Diss., The University of Arizona, 1997. http://hdl.handle.net/10150/288710.

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The primary goal of this dissertation project has been the study of metal affinity interactions in metal recovery and bioremediation. During the first part of this research a mathematical model that describes the affinity partitioning of metal ions in aqueous two-phase systems was derived. The model has been used to calculate complex formation constants between metal ions in solution and affinity ligands, satisfactorily describing their partition behavior. Simulation using this model shows the great effect that pH has on the partitioning of metal ions suggesting better conditions for the separ

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16

Teruya, Kanae. "Development of Affinity-Based Chemical Probes for Fluorescence Detection of Human Carbonic Anhydrases." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367357.

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The development of small molecule affinity-based chemical probes as research tools for studying the role of carbonic anhydrases (CAs) in their wider biological context has become an active field of research owing to an increasing awareness of the therapeutic relevance of this enzyme family, particularly in diseases such as glaucoma (CA II) and solid tumors (CA IX, CA XII). High CA isozyme selectivity, low nonspecific labeling, and efficient labeling yield are the characteristics of an ideal chemical probe, however achieving an effective balance of all three properties is challenging. A panel

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17

Laffey, Brian David. "Monoclonal antibodies to bovine serum albumin : affinity purification and physicochemical characterization dc by Brian David Laffey." Thesis, Massachusetts Institute of Technology, 1995. http://hdl.handle.net/1721.1/32640.

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18

Swers, Jeffrey Seth. "Isolation and engineering of a high affinity antibody against P-selectin glycoprotein ligand-1 (PSGL-1)." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/32323.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 2005.<br>Vita.<br>Includes bibliographical references (leaves 87-91).<br>We aim to develop novel protein antagonists of P-selectin adhesion as anti- inflammatory therapeutics. Blocking P-selectin adhesion is particularly attractive because this adhesion mediates leukocyte rolling which occurs early in the inflammatory cascade before extensive tissue damage caused by the amplification of inflammation by proinflammatory cytokines. Currently, no subnanomolar antagonists of selectin adhesion are available. The l

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19

Balliu, Aleksandra. "Exploring molecular interactions between polypeptide conjugates and protein targets : Manipulating affinity by chemical modifications." Doctoral thesis, Uppsala universitet, Organisk kemi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-327121.

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In this thesis molecular interactions between polypeptide conjugates and protein targets were investigated. Polypeptides were derivatized with small organic molecules, peptides and oligonucleotides. New strategies were developed with the aim to increase affinities for proteins of biological interest. A 42-residue polypeptide (4-C15L8) conjugated to a small organic molecule 3,5-bis[[bis(2-pyridylmethyl)amino]methyl]benzoic acid (PP1), was shown to bind glycogen phosphorylase a (GPa) in the presence of zinc ions. Under the assumption that hydrophobic interactions dominated the binding energy, th

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20

Kuzmich, Oleksandra. "Metal Labeling for Low Affinity Binding Biomolecules." Doctoral thesis, Humboldt-Universität zu Berlin, 2018. http://dx.doi.org/10.18452/18862.

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Unter den Techniken der chemischen Proteomik hat Capture Compound – Massenspektrometrie (CCMS) den Vorteil, Interaktionen von Molekülen mit geringer Affinität zueinander effektiv untersuchen zu können. CCMS beruht auf kleinen molekularen Sonden (Capture Compounds, CCs), die aus drei funktionalen Bestandteilen bestehen: die Selektivitätsfunktion, ist ein kleines Molekül, das mit einem Zielprotein eine schwache Wechselwirkung eingeht. Die zweite Funktionalität erlaubt kovalente Anhaftung der molekularen Sonde an Proteine. Der dritte Anteil erlaubt Detektion mit sehr guten Sensitivität; allerding

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21

Taylor, Georgette Nicola Lewis. "Variations on a theme : patterns of congruence and divergence among 18th century chemical affinity theories." Thesis, University College London (University of London), 2006. http://discovery.ucl.ac.uk/10723/.

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The doctrine of affinity deserves to be recognised by historians of chemistry as the foundational basis of the discipline of chemistry as it was practiced in Britain during the 18th century. It attained this status through its crucial structural role in the pedagogy of the discipline. The importance of pedagogy and training in the practice of science is currently being reassessed by a number of historians, and my research contributes to this historiographical endeavour. My analysis of the variety of theories sheltered under the umbrella term ‘affinity theory’ has emphasised the role of pedagog

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22

Al, Bittar Sheiraz. "3-Deoxyanthocyanins : Chemical synthesis, structural transformations, affinity for metal ions and serum albumin, antioxidant activity." Thesis, Avignon, 2016. http://www.theses.fr/2016AVIG0264.

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Ce travail porte sur la synthèse chimique d’analogues simples d’anthocyanes, une classe majeure de pigments naturels solubles dans l’eau. Onze ions flavylium substitués par des groupements hydroxyl,méthoxyl et beta-D-glucopyranosyloxyl en positions 4’, 5 et 7 ont été préparés en utilisant des procédures simples. De plus, les deux principales 3-désoxyanthocyanidines du sorgho rouge, l’apigéninidine (APN) et la lutéolinidine (LTN), ont été synthétisées en une seule étape. Les propriétés physico-chimiques ainsi que l’activité antioxydante ont été étudiées pour le chlorure de 3’,4’,7-trihydroxyfla

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23

Ogata, Yuko. "Automated affinity measurement of biospecific interactions using a lab-on-valve apparatus coupled to electrospray ionization mass spectrometry /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/11607.

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24

Keymeulen, Flore. "Development and physico-chemical characterization of supramolecular systems for anion recognition in aqueous media." Doctoral thesis, Universite Libre de Bruxelles, 2016. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/223788.

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Anion recognition is a topical area of research warranted by the potential applications of anion receptors in environmental and biological monitoring. Anions are indeed widespread in nature, are involved in many biochemical processes and are also major aqueous pollutants. Molecular receptors able to recognize anions with high affinity and selectivity in organic solvents are well documented in the literature but only few systems are efficient in aqueous media. Water is undeniably a particularly challenging solvent to work with due to the competition of water in the recognition process. Moreover

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25

Yuan, Hongyu. "Optimization of an Innovative Npu-N Resin Production." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1555591103161637.

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26

PUNZALAN, LOUVY LYNN CALVELO. "Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library." Kyoto University, 2020. http://hdl.handle.net/2433/259001.

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27

Bagchi, Pritha. "Expanding the metallomics toolbox: Development of chemical and biological methods in understanding copper biochemistry." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/52160.

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Copper is an essential trace element and required for various biological processes, but free copper is toxic. Therefore, copper is tightly regulated in living cells and disruptions in this homeostatic machinery are implicated in numerous diseases. The current understanding of copper homeostasis is substantial but incomplete, particularly in regard to storage and exchange at the subcellular level. Intracellular copper is primarily present in the monovalent oxidation state. Therefore, copper(I) selective fluorescent probes can be utilized for imaging exchangeable copper ions in live cells, but t

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28

Chivers, Claire Elizabeth. "Investigating high-affinity non-covalent protein-ligand interaction via variants of streptavidin." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:631c65ed-08d9-484e-a8df-309a4c95df45.

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The Streptomyces avidinii protein streptavidin binds the small molecule biotin (vitamin H / B₇) with extraordinary stability, resulting in the streptavidin-biotin interaction being one of the strongest non-covalent interactions known in nature (K<sub>d</sub> ~ 10<sup>-14</sup> M). The stable and rapid biotin-binding, together with high resistance to heat, pH and proteolysis, has given streptavidin huge utility, both in vivo and in vitro. Accordingly, streptavidin has become a widely used tool in many different biotechnological applications. Streptavidin has also been the subject of extensive r

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29

Garcia-Barron, Javier Enrique. "Synthesis and study of chelating polymers and their application to protein and metal separation from aqueous solutions using novel metal affinity interaction techniques." Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/283931.

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The main objective of this research work was the development, synthesis, and study of polymeric chelating derivatives. These derivatives were characterized in terms of their specific metal affinity interaction with biomolecules and metal ions. These engineered materials were used to test their feasibility as tools for separation of proteins and heavy metal ions from aqueous solutions using different affinity separation techniques. Linear and branched polymers were synthesized to create a variety of materials. Among the linear polymers synthesized was the chelated monomethoxy poly(ethylene) gly

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30

Authimoolam, Sundar Prasanth. "STABILITY OF AFFINITY BASED LAYER-BY-LAYER POLYMERIC SELF-ASSEMBLIES FOR ORAL WOUND APPLICATIONS." UKnowledge, 2011. http://uknowledge.uky.edu/cme_etds/3.

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Oral mucositis is a painful and debilitating chronic inflammatory condition that can result from chemo and/or radiotherapy. While current treatment strategies which provide temporary relief exist, there is still an unmet clinical need for a robust long active barrier strategy which can simultaneously provide protection and release drug to enhance the wound healing response. It is proposed that an affinity based layer-by-layer self-assembled barrier administered as a series of mouth rinses can allow for wound specific drug delivery, providing an effective regenerative therapy. In this work, bio

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31

Knave, Axel. "Production and characterization of alternative scaffold proteins for medical applications." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-278838.

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Antibodies, as forerunners in the field of biological drugs, are originally an organism’s answer to the invasion of different pathogens. Today, antibodies are a common treatment for many chronic diseases such as the immune-mediated inflammatory diseases rheumatoid arthritis or psoriasis. It is suspected that the cytokines interleukin 17a (IL17a) and interleukin 17c (IL17c) are involved in those diseases and are commonly treated with antibodies that inhibit the cytokines. Even though antibodies have been a huge success as biological drugs they also have downsides when it comes to their producti

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32

Bateson, Hannah. "Detection and enrichment of cytochrome P450s using bespoke affinity chromatography and proteomic techniques : development of chemical immobilisation and novel affinity chromatography methods, with subsequent proteomic analysis, for the characterisation of cytochrome P450s important in cancer research." Thesis, University of Bradford, 2012. http://hdl.handle.net/10454/5712.

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Introduction: Cellular membrane proteins, such as the cytochrome P450 enzyme superfamily (P450), have important roles in the physiology of the cell. P450s are important in metabolising endogenous molecules, as well as metabolising xenobiotic substances for detoxification and excretion. P450s are also implicated in cancer as they can act to 'negatively' de-activate or 'positively' activate cancer therapeutics. Identifying specific P450s that are highly up-regulated at the tumour site could be used to predict drug response and formulate targeted cancer therapy to help diminish systemic side-effe

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33

Poma, Alessandro. "Automatic solid-phase synthesis of molecularly imprinted nanoparticles (MIP NPs)." Thesis, Cranfield University, 2012. http://dspace.lib.cranfield.ac.uk/handle/1826/7911.

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Molecularly Imprinted Polymers (MIPs) are potential generic alternatives to antibodies in diagnostics and separations. To compete with biomolecules in these technological niches, MIPs need to share the characteristics of antibodies (solubility, size, specificity and affinity) whilst maintaining the advantages of MIPs (low cost, short development time and high stability). For this reason the interest in preparing MIPs as nanoparticles (MIP NPs) has increased exponentially in the last decade. Cont/d.

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34

Harper, Robert T. "Determination of the proton affinities of gas phase peptides by mass spectrometry and computational chemistry." Scholarly Commons, 2007. https://scholarlycommons.pacific.edu/uop_etds/673.

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Helices in proteins have substantial permanent dipole moments arising from the nearly perfect alignment of the individual dipole moments of each peptide bond. Interaction with this helix "macrodipole" is thought to perturb the pKa values of basic or acidic residues at the helix termini. The goal of this project is to investigate the effect of the helix confonnation on the proton affinities ofbasic amino acids placed at theN- or Ctenninus of helical model peptides in the gas phase. Several series of model peptides having a basic residue, lysine (K) or 2,3- diaminopropionic acid (Dap ), located

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35

Datta, Saurav. "FUNCTIONALIZED POLYMERIC MEMBRANES FOR BIOSEPARATION AND BIOCATALYSIS." UKnowledge, 2007. http://uknowledge.uky.edu/cme_etds/26.

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Functionalized polymeric membrane based techniques are becoming increasingly popular in biotechnology, food and pharmaceutical industries due to their versatility and hydrodynamic benefits over traditional materials and methods. This research work has been directed towards the development of functionalized polymeric membranes, extensive experimental and theoretical analyses of some of the fundamental aspects of accessibility, membrane fouling and enzyme catalysis, and applications in affinity based bioseparation and biocatalysis. In this research work, the impact of different types of function

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36

Ku, Xin [Verfasser], Bernhard Akademischer Betreuer] Küster, and Dieter [Akademischer Betreuer] [Langosch. "Development and application of small molecule probes for kinase affinity purification and quantitative chemical proteomics / Xin Ku. Gutachter: Bernhard Küster ; Dieter Langosch. Betreuer: Bernhard Küster." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/105346763X/34.

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Zhou, Yipin. "Synthesis and Biophysical Characterization of Polymerized Hemoglobin Dispersions of Varying Size and Oxygen Affinity as Potential Oxygen Carriers for use in Transfusion Medicine." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1321406529.

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38

Lo, Bryan. "Site-directed cysteine mutagenesis and chemical modification of the high affinity Na§+/glucose transporter (SGLT1), elucidation of structure/function relationships underlying Na§+ permeation through the transporter." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ35230.pdf.

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Cigler, Marko [Verfasser], Kathrin [Akademischer Betreuer] Lang, Kathrin [Gutachter] Lang, and Stephan [Gutachter] Hacker. "Genetically encoding unnatural amino acids: Novel tools for protein labelling and chemical stabilisation of low-affinity protein complexes / Marko Cigler ; Gutachter: Kathrin Lang, Stephan Hacker ; Betreuer: Kathrin Lang." München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1220322318/34.

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40

Chalumeau, Céline. "Développement d’outils chimiques pour l’élucidation de la biosynthèse des flavonoïdes du raisin : anthocyanes versus proanthocyanidines." Thesis, Bordeaux 1, 2010. http://www.theses.fr/2010BOR14188/document.

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Ces dernières années, des progrès remarquables ont été accomplis afin d’élucider la biosynthèse des flavonoïdes. Cependant les dernières étapes menant à la formation des proanthocyanidines ou tannins condensés issus de la vigne, restent à ce jour inconnues. Dans le but de déterminer si une ou plusieurs enzyme(s) spécifique(s) sont impliquées dans cette voie de biosynthèse, nous avons développé une approche de protéomique chimique, impliquant des matrices d’affinité constituées de substrats de type flavanols greffés sur un support solide. La validation de ces outils à l’aide de LDOX, une enzyme

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41

Schmitt, Philippe. "Potentiels de l'électrophorèse capillaire dans l'analyse des pesticides et des substances humiques : application à l'étude des interactions pesticides - substances humiques." Vandoeuvre-les-Nancy, INPL, 1996. http://www.theses.fr/1996INPL117N.

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Différentes méthodes électrophorétiques ont été développées pour l'analyse de pesticides et de substances humiques. En électrophorèse capillaire de zone (CZE), des herbicides cationiques (s-triazines) et/ou anioniques (acides phénoxyacétiques) peuvent être séparés aisément avec une limite de détection de l'ordre de 10 g/l. La CZE est également efficace dans l'analyse du comportement électrophorétique de mélanges complexes de polyélectrolytes anioniques tels que les substances humiques. Un exemple d'application de la CZE est donné dans l'analyse des métabolites hydroxyles de l'atrazine lors de

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Stimple, Samuel Douglas. "Recent Advances in Developing Molecular Biotechnology Tools for Metabolic Engineering and Recombinant Protein Purification." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1514494485801145.

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43

Bull, James. "Application of Quantum Mechanics to Fundamental Interactions in Chemical Physics: Studies of Atom-Molecule and Ion-Molecule Interactions Under Single-Collision Conditions: Crossed Molecular Beams; Single-Crystal Mössbauer Spectroscopy: Microscopic Tensor Properties of ⁵⁷Fe Sites in Inorganic Ferrous High-Spin Compounds." Thesis, University of Canterbury. Department of Chemistry, 2010. http://hdl.handle.net/10092/4292.

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As part of this project and in preparation for future experimental studies of gas-phase ion-molecule reactions, extensive modification and characterization of the crossed molecular beam machine in the Department of Chemistry, University of Canterbury has been carried out. This instrument has been configured and some preliminary testing completed to enable the future study of gas-phase ion-molecule collisions of H⁺₃ and Y⁻ (Y = F, Cl, Br) with dipole-oriented CZ₃X (Z = H, F and X = F, Cl, Br). Theoretical calculations (ab initio and density functional theory) are reported on previously experime

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Pinato, Odra. "Analysis of allergenic proteins by mass spectrometry." Doctoral thesis, Università degli studi di Padova, 2010. http://hdl.handle.net/11577/3427029.

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MS Analysis of Allergenic Proteins. Food allergy is a significant worldwide public health issue. Proteins from cow's milk, chicken eggs, soybean and peanuts are the most frequent allergens contained in the complex foods prepared by industrial processes. Allergenic proteins can induce allergic reaction in their native structural state or upon chemical or conformational changes induced by the industrial treatments. Nowadays, the identification of allergenic proteins in foods is conducted by using immunochemical methods such as ELISA tests, but these techniques suffer from several limitations du

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Zaveckas, Mindaugas. "Rekombinantinio žmogaus granulocitų kolonijas stimuliuojančio faktoriaus pasiskirstymas ir renatūracija vandens dvifazėse sistemose, dalyvaujant chelatuotiems metalų jonams." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2005. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2005~D_20051116_154617-68277.

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The contribution of Cys17 and surface-exposed histidine residues in rhG-CSF interaction with Cu(II), Ni(II) and Hg(II) ions chelated by Light Resistant Yellow 2KT-polyethylene glycol derivative was evaluated in aqueous two-phase systems composed of polyethylene glycol (PEG) and dextran. It was determined that His43, His52, His156 and His170 residues are involved in protein interaction with chelated Cu(II) ions. Protein interaction with chelated Ni(II) is governed by His52 and His170 residues, though Cys17 is also involved. The contribution of Cys17 side chain is dominant in the interaction bet

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Лыкова, Ю. А., та Yu A. Lykova. "Исследование электрохимического восстановления 2-замещеных хиноксалинов в апротонной среде. Количественное определение вольтамперометрическим методом : магистерская диссертация". Master's thesis, б. и, 2020. http://hdl.handle.net/10995/94640.

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Объектами исследования являются 2-замещеные хиноксалины. Целью данной работы является изучение химических свойств хиноксалина и его производных. В работе рассматривалось восстановление производных хиноксалина (окислительно-восстановительные свойства, потенциал восстановления, ЭПР спектр, квантово-химический расчеты). Сравнение восстановительных свойств синтезированного ряда производных хиноксалина. Определено количество электронов, участвующих в процессе восстановления производных хиноксалина. Смоделирован процесс восстановления. Доказан одноэлектронный переход хиноксалина. Далее приводится ко

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Abou-Dalle-Messaikeh, Hana. "Polymères insolubles fonctionnels : affinité spécifique pour les anticorps anti VIIIc." Paris 13, 1989. http://www.theses.fr/1989PA132006.

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Recherche d'adsorbants synthétiques constitués de polymères fonctionnels capables d'adsorber les anticorps anti viii: c dans des systèmes d'épuration plasmatique. Substitution de fonction sulfonate et sulfamion d'un acide aminés ou de deux acides amines sur un polystyrène

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Tait, Timo. "The production and purification of functional steroid hormone receptor ligand binding domains towards the development of a biological endocrine disruptor detection system." Thesis, Stellenbosch : Stellenbosch University, 2015. http://hdl.handle.net/10019.1/96811.

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Thesis (MSc)--Stellenbosch University, 2015.<br>ENGLISH ABSTRACT: During the last two and a half decades a large body of research has accumulated indicating the presence of various natural and synthetic chemical compounds within the environment capable of inducing hormone-like responses in humans and animals. Such compounds, termed endocrine disruptors, have been implicated in a variety of developmental, reproductive and physiological abnormalities which have been shown to converge on the endocrine system. Given that endocrine disrupters are comprised of a diverse group of molecules with dissi

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Jia, Fuchao. "Thermodynamic and structural study of the interaction between Ru(bpy)2dppz 2+ and DNA." Phd thesis, Université de Strasbourg, 2013. http://tel.archives-ouvertes.fr/tel-01062684.

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Dans une première partie, nous mesurons l'affinité de l'interaction entre [Ru(pby)2dppz]2+ et l'ADN en utilisant la luminescence induite lors de la complexation. Nous étudions l'évolution de l'affinité lorsque la force ionique de la solution augmente. Dans une deuxième partie, nous modifions les extrémités d'un double brin d'ADN en y greffant des fluorophores. De la mesure de transfert d'énergie non-radiative entre ces fluorophores, nous étudions l'évolution de la longueur du complexe. Nous effectuons un dosage d'un double brin de 15 paires de bases d'ADN par le complexe ruthéné. Nous nous ser

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Lima, Maria da ConceiÃÃo LÃbo. "ContribuiÃÃo ao conhecimento quÃmico de plantas do Nordeste do Brasil: Lippia affinis gracillis H. B. K." Universidade Federal do CearÃ, 2006. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=1577.

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FundaÃÃo Cearense de Apoio ao Desenvolvimento Cientifico e TecnolÃgico<br>Este trabalho descreve a investigaÃÃo fitoquÃmica das raÃzes, folhas e talos de Lippia affinis gracillis H.B.K. (Verbenaceae), popularmente conhecida no Nordeste do Brasil como âalecrim de vaqueiroâ. A anÃlise cromatogrÃfica dos extratos hexÃnico e etanÃlico das raÃzes e folhas de Lippia aff. gracillis permitiu o isolamento e caracterizaÃÃo do lapachenol (1), dos triterpenos friedelinona (2), acetato de epifriedelanil (3), Ãcido 3-acetil oleanÃlico (6) e lantandeno-A (7), das mistura dos esterÃides -sitosterol e

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