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Tesi sul tema "Cell metabolism Regulation"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 28 gennaio 2023

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1

Tejedor, Vaquero Sonia 1988. "Influence of metabolism in the regulation of T cell differentiation." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/664638.

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Glucose is a key nutrient for T cells. Despite that T cell activation is impaired when they are deprived of glucose, it has also been shown that T effector responses can be elicited in vivo in glucose-poor environments, such as the intratumoral niche, which raises the question of how these cells can maintain their function in nutrient-restricted sites. In this work, we analyzed the ability of T effector cells to be activated by pro-inflammatory polarizing conditions under limiting glucose availability, using an in vitro model in which effector Th0 cells were restimulated to secondary effector

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2

Babić, Nikolina. "Regulation of energy metabolism of heart myoblasts /." Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/11563.

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3

Mathew, Jasmin. "Keratin 8/18 regulation of hepatic cell death and metabolism." Thesis, Université Laval, 2009. http://www.theses.ulaval.ca/2009/26554/26554.pdf.

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4

Szkolnicka, Dagmara Maria. "MicroRNA regulation of drug metabolism in stem cell-derived hepatocytes." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/23421.

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The liver is a multi-functional and highly regenerative organ. While resilient, the liver is susceptible to organ damage and failure. In both the acute and chronic settings liver disease has dire consequences for health. A common cause of liver damage is adverse reactions to drugs which can lead to drug induced liver injury (DILI). This creates major problems for patients, clinicians, the pharmaceutical industry and regulatory authorities. In the context of drug overdose or serious adverse reactions, liver failure can be acute and life threatening, and in some cases require orthotopic liver tr

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5

Mukherjee, Abir. "ROLE OF LYSOPHOSPHATIDIC ACID IN REGULATION OF CANCER CELL METABOLISM." VCU Scholars Compass, 2012. http://scholarscompass.vcu.edu/etd/391.

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The simplest phospholipid, lysophosphatidic acid (LPA), is a heat stable component of serum known for its proliferative and migratory activities in cancer cells. Strong evidence suggests that LPA production and expression of its receptors are dysregulated in multiple human malignancies. The mechanism behind LPA-mediated tumor cell growth and oncogenesis remains poorly understood. In this thesis project I used ovarian and other cancer cells as a model system to examine the hypothesis that LPA present in the tumor microenvironment is a pathophysiological determinant of hyperactive de novo lipoge

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6

Syal, Charvi. "Epigenetic Regulation of Lipid Metabolism in Neural Stem Cell Fate Decision." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/38706.

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Bioactive lipids have emerged as prominent regulators of neural stem and progenitor cell (NPC) function under both physiological and pathological conditions. However, how lipid metabolism is regulated, and its role in modulation of NPC function remains unknown. In this regard, my study defines a novel epigenetic pathway that regulates lipid metabolism to determine NPC proliferation versus differentiation. Specifically, I show that activation of an atypical protein kinase C (aPKC)-mediated Ser436 phosphorylation of CREB binding protein (CBP) by aging, metformin stimulation and continued passagi

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7

Ng, Shyh Chang. "Regulation of Stem Cell Metabolism by the Lin28/let-7 Axis." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11217.

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My PhD thesis is focused on two fundamental aspects of stem cell metabolism: (1) the role of Lin28 in programming stem cell metabolism, and (2) how metabolism in turn fuels and governs pluripotency. Our studies led us to discover that the stem cell factor Lin28a promotes gigantism by enhancing glucose metabolism in mice, coinciding with discoveries that LIN28B polymorphisms influence height variation in human GWAS. Subsequently, we discovered that the Lin28/let-7 pathway controls glucose metabolism by orchestrating the upregulation of multiple insulin-PI3K-mTOR components, particularly in skel

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8

Mofarrahi, Mahroo. "Regulation of skeletal muscle satellite cell proliferation by NADPH oxidase." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111521.

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Skeletal satellite cells are adult stem cells located among muscle fibers. Proliferation, migration and subsequent differentiation of these cells are critical steps in the repair of muscle injury. We document in this study the roles and mechanisms through which the NAPDH oxidase complex regulates skeletal satellite cell proliferation. The NADPH oxidase subunits Nox2, Nox4, p22phox, p47phox and p67 phox were detected in primary human and murine skeletal muscle satellite cells. In human satellite cells, NADPH oxidase-fusion proteins were localized in the cytosolic and membrane compartments of th

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9

Aitchison, Robert E. D. "Mammary cell cyclic AMP : regulation of breakdown and influence on protein phosphorylation." Thesis, University of Glasgow, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.303363.

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10

Beauchamp, Pascal. "The functional role of the RNA-binding protein HuR in the regulation of muscle cell differentiation /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111586.

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Muscle tissue development (myogenesis) involves the formation of specific fibers (myotubes) from muscle cells (myoblasts). For this to occur, the sequential expression of Myogenic Regulatory Factors (MRFs), such as MyoD and myogenin, is required. The expression of these MRFs is regulated posttranscriptionally by the RNA-binding protein HuR, whereby HuR associates with the 3'-untranslated regions of MyoD and myogenin mRNA, leading to a significant increase in their half-lives. Here we show that the cleavage of HuR by caspases at the aspartate (D) 226 residue is one of the main regulators of its

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11

Nilsson, Per. "Allosteric Regulation of mRNA Metabolism : -Mechanisms of Cap-Dependent Regulation of Poly(A)-specific Ribonuclease (PARN)." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8647.

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12

Lin, Weiyang. "Phospholipid metabolism in the MCF-7 cell cycle, regulation of phosphatidylcholine accumulation." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0015/NQ53065.pdf.

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13

Rainer, Roman Josef. "Identification of differential regulation in central carbon metabolism between related cell lines." Doctoral thesis, Humboldt-Universität zu Berlin, 2020. http://dx.doi.org/10.18452/22117.

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Darmkrebszellen und T-Zellen regulieren ihren zentralen Kohlenstoffmetabolismus um ihren anabolen Bedarf zu erfüllen. Tumorzellen mit einer KRAS- oder BRAF-Mutation zeigen ein schnelles Wachstum, welches eine Umprogrammierung des Metabolismus vor aussetzt. Der mitochondriale T-Zellen-Aktivierungsinhibitor (TCAIM) ist bekannt dafür die mitochondriale Zellstruktur zu beeinflussen. Der Einfluss auf den Metabolismus nicht klar. In dieser Arbeit präsentiere ich erstmalig ein mathematische Model des zentralen Kohlen stoffmetabolismus in Darmkrebszellen und T-Zellen. Mithilfe dieses Modells an

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14

Koseoglu, Mehmet Murat Marzluff William F. "Cell cycle regulation of the stem loop binding protein a key regulator in histone mRNA metabolism /." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,2081.

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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Feb. 17, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biology Graduate Studies in Molecular, Cell, and Developmental Biology." Discipline: Biology; Department/School: Biology.

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15

Tomac, Andreas C. "Glial cell line-derived neurotrophic factor : expression patterns, neuronal transport, regulation, effects and receptor dependence /." Stockholm, 1998. http://diss.kib.ki.se/search/diss.se.cfm?19980618toma.

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16

Atmosukarto, Ines Irene Caterina. "Biochemical and genetic approach to the characterisation of Tec function in the mouse." Title page, contents and summary only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09pha881.pdf.

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Copy of author's previously published work inserted. Includes bibliographical references (leaves 160-182). Concentrates mainly on the characterisation of the molecular mechanism of action of the tec protein tyrosine kinase using biochemical and genetic approaches.

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17

Pursglove, Sharon Elizabeth. "Biophysical analysis of Tec Kinase regulatory regions : implications for the control of Kinase activity." Title page, contents and summary only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09php9863.pdf.

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18

Secinaro, Michael Anthony. "The Contribution Of Metabolism To The Regulation Of Caspase Activity And Cell Death In T Lymphocytes." ScholarWorks @ UVM, 2019. https://scholarworks.uvm.edu/graddis/1000.

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Abstract (sommario):

During an immune response, T cell activation is mirrored by a dramatic metabolic shift from oxidative phosphorylation to glycolysis. The upregulation of glycolysis allows the cell to generate the molecules needed to rapidly proliferate and to synthesize effector molecules. The resolution of the T cell response is characterized by equally fast death of most effector T cells. The remaining T cells shift back to oxidative phosphorylation, allowing the cell to survive as a memory T cell. The upregulation of glycolysis and proliferation during the effector phase is paralleled by an increased sensit

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19

Chenery, Alistair Lee. "Regulation of mucosal T cell responses by intestinal helminths and retinoic acid metabolism." Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57723.

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Abstract (sommario):

Mucosal immune diseases such as asthma and inflammatory bowel disease are associated with major environmental factors - diet, geography, hygiene, infections - that contribute to disease risk. The mucosal immune system is in direct contact with the external environment and must balance protective immune responses with tolerance to innocuous antigens. Since chronic inflammation at mucosal sites depends on a diverse set of T cell-driven responses, understanding the factors that regulate mucosal T cell differentiation and function is key to developing better treatments to a variety of inflammatory

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20

Ding, Min Judd Robert L. "Regulation of glucose metabolism in a hepatic and muscle cell line by adiponectin." Auburn, Ala., 2005. http://hdl.handle.net/10415/1263.

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21

Thwe, Phyu Myat. "Characterizing The Role And Regulation Of Glycogen Metabolism In Dendritic Cell Immune Responses." ScholarWorks @ UVM, 2018. https://scholarworks.uvm.edu/graddis/935.

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Abstract (sommario):

Dendritic cells (DCs) are the most potent professional antigen presenting cells (pAPCs) of the immune system and play a fundamental role in coordinating innate and adaptive immune responses. Through the expression of a wide array of pattern recognition receptors (PRRs), such as toll-like receptors (TLRs), DCs recognize a variety of microbial pathogens and infectious stimuli. Stimulation of DCs through TLR ligation results in a rapid series of activation-associated events, termed "maturation," which include the upregulation of surface co-stimulatory molecule expression, inflammatory cytokine se

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22

Fultz, Kimberly Elizabeth. "APC-dependent regulation of polyamine metabolism and apoptosis in human colon tumor cells." Diss., The University of Arizona, 2002. http://hdl.handle.net/10150/280176.

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Mutation/deletion of the adenomatous polyposis coli (APC) tumor suppressor gene in germline cells of rodents and humans is associated with increased intestinal activity of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, and intestinal neoplasia. To study the role of APC in signaling ODC expression, the human colon tumor cell line HT29 (wtAPC -/-) was stably transfected with a zinc-inducible wild-type APC gene. Addition of ZnCl2 to HT29-APC cells increased wild-type APC protein and Mad1 RNA and protein, and decreased levels of c-myc and ODC RNA and protein, relative to

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23

Faulkner, Ashton. "Regulation of endothelial cell metabolism by agonist-activated PPAR? : implications for angiogenesis-related activity." Thesis, Royal Veterinary College (University of London), 2017. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.731287.

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24

Waddington, Kirsty Elizabeth. "Regulation of membrane lipid metabolism and immune cell function by the nuclear receptor LXR." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10054993/.

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Liver X receptors (LXRs) are transcription factors with a critical role in multiple lipid metabolic pathways, and a broad range of effects on inflammatory and immune responses. I hypothesised that LXRs modulate CD4+ T cell function by regulating plasma membrane lipid rafts- highly ordered cholesterol and glycosphingolipid (GSL) enriched regions important for T-cell antigen receptor (TCR) signalling. Importantly, the GSL biosynthesis enzyme UGCG was identified as a novel LXR target gene in multiple human immune cell subsets. In CD4+ T cells, LXR activation with the synthetic ligand GW3965 regul

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25

McCarthy, Michael Thomas. "Mechanisms of NKG2D ligand regulation." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:69de3276-0b1e-4174-9309-988242468682.

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Background: The NKG2D ligands are a set of cell surface proteins, the expression of which can make cells susceptible to immunity mediated by NKG2D receptor expressing cells, which include NK cells, CD8<sup>+</sup> αβ T cells and γδ T cells. The NKG2D ligands are known to be expressed in distinct settings, including viral infection, cancer, T cell activation, and cellular proliferation, settings also tightly associated with Warburg metabolism. The molecular events which determine NKG2D ligand expression status are unknown. Aims: We aim to enhance understanding of the deterministic molecular eve

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26

Crosby, Priya. "Metabolic regulation of circadian timekeeping." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/269019.

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Circadian rhythms are self-sustained endogenous biological oscillations with a period of approximately 24 hours. These rhythms are observed widely across kingdoms and at all levels of biological scale. Recent work has shown there to be circadian variation in metabolism, both at the organismal and cellular level. It has also been posited that rhythmic production of metabolites might be essential for maintenance of circadian rhythmicity within cells, even in the absence of nascent transcription. The first portion of this thesis investigates the contribution of primary carbohydrate metabolism to

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27

Schuster, Susanne. "The NAMPT-mediated NAD salvage pathway in cancer cell metabolism and its regulation by resveratrol." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-173401.

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Nicotinamide adenine dinucleotide (NAD) is a key regulator of several metabolic and signaling pathways that are relevant in cancer cell survival. Cancer cells have an increased energy demand associated with an increased NAD turnover. Nicotinamide phosphoribosyltransferase (NAMPT), a key enzyme of the NAD salvage pathway, plays a crucial role in maintaining the intracellular NAD levels and in regulating the activity of NAD-dependent enzymes, such as sirtuins (SIRTs). The inhibition of NAMPT activity and the use of phytochemicals, such as resveratrol, represent novel therapeutic approaches in ca

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28

Rainer, Roman Josef [Verfasser]. "Identification of differential regulation in central carbon metabolism between related cell lines / Roman Josef Rainer." Berlin : Humboldt-Universität zu Berlin, 2020. http://d-nb.info/1222028697/34.

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29

Taruttis-Glagoleff, Franziska [Verfasser], and Rainer [Akademischer Betreuer] Spang. "Modeling MYC-dependent regulation of gene expression and cell metabolism in B-cell lymphomas / Franziska Taruttis-Glagoleff ; Betreuer: Rainer Spang." Regensburg : Universitätsbibliothek Regensburg, 2021. http://d-nb.info/1230135979/34.

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30

English, Tamara Erica Carleton University Dissertation Biology. "Differential gene expression in response to freezing and anoxia in the intertidal marine gastropod, littorina littorea." Ottawa, 2000.

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31

Okemo, Pauline Asami. "Regulation of plant programmed cell death by energy metabolism in the Australian resurrection grass Tripogon loliiformis." Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/205617/1/Pauline_Okemo_Thesis.pdf.

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Recent studies have shown that T.loliiformis, a resurrection grass, may use the tight regulation of PCD pathways like autophagy to facilitate desiccation tolerance. The aim of this project was to further investigate the mechanisms that T.loliiformis use to suppress PCD and survive prolonged periods of water deficit. This study provides additional insight on how T.loliiformis attains desiccation tolerance that significantly contributes to our knowledge on the pathways and mechanisms used by resurrection plants. The findings from this study will hopefully be employed to harness drought tolerant

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32

Purcell, Robert. "Regulation of endothelial cell function by omega-3 fatty acids and their oxygenated metabolites : mediators of vascular protection?" Thesis, Royal Veterinary College (University of London), 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701662.

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33

James, Andrew. "Metabolic regulation of the plasma membrane calcium pump in pancreatic ductal adenocarcinoma." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/metabolic-regulation-of-the-plasma-membrane-calcium-pump-in-pancreatic-ductal-adenocarcinoma(0533b59c-e6ee-41fb-ad32-cb4784eadfa1).html.

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Abstract (sommario):

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive form of cancer with poor prognosis and limited treatment options. Since many patients present with metastatic disease and are thus ineligible for surgical resection, PDAC is almost ubiquitously fatal; new treatment options are therefore needed to combat this disease. A key hallmark of many cancers, including PDAC, is metabolic reprogramming and a shift towards a high glycolytic rate, known as the Warburg effect. This allows cancer cells to generate ATP in the face of hypoxia and to meet the increased metabolic requirements associated wit

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34

Moore, Jocelyn. "Post-transcriptional control of Drosophila pole plasm component, germ cell-less." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115700.

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Mechanisms of post-transcriptional control are critical to deploy RNAs and proteins asymmetrically to a discrete region of cytoplasm at the posterior of the Drosophila oocyte and embryo, called the pole plasm and thus allow differentiation of the germline. Research presented in this thesis investigates the post-transcriptional control of Drosophila pole plasm component germ cell-less (gcl ). Maternal gcl activity is required for germ cell specification and gcl RNA and protein accumulate asymmetrically in the pole plasm. gcl RNA, but not Gcl protein, is also detected in somatic regions of the e

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35

Jones, Andrea Kathryn. "The role of cyclic AMP in the regulation of cholesterol metabolism in human monocytes/macrophage cell lines." Thesis, Royal Veterinary College (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522614.

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36

De, Lira Maria Nathalia [Verfasser], and Elita [Gutachter] Avota. "The regulation of T cell metabolism by neutral sphingomyelinase 2 / Maria Nathalia De Lira ; Gutachter: Elita Avota." Würzburg : Universität Würzburg, 2020. http://d-nb.info/1221963252/34.

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37

Chantarasinlapin, Praew. "Regulation of Adipocyte Differentiation and Metabolism: Rab5-Guanine Nucleotide Exchange Factors and Methylglyoxal." FIU Digital Commons, 2017. http://digitalcommons.fiu.edu/etd/3227.

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Internalization and trafficking of ligand-receptor complex rely on a particular set of proteins, e.g. small GTPase protein Rab5 and its activators called guanine nucleotide exchange factors. Rab5-activating protein 6 (RAP6), a Vps9-containing protein, may participate in Rab5-mediated insulin signaling and receptor trafficking. A dicarbonyl compound methylglyoxal was found to alter insulin signaling in preadipocytes. This dissertation aimed to investigate the association of RAP6 activity on 3T3-L1 preadipocyte differentiation and those driven by methylglyoxal. Overexpression of RAP6 inhibited p

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38

DeMille, Desiree. "Identifying and Characterizing Yeast PAS Kinase 1 Substrates Reveals Regulation of Mitochondrial and Cell Growth Pathways." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5930.

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Glucose allocation is an important cellular process that is misregulated in the interrelated diseases obesity, diabetes and cancer. Cells have evolved critical mechanisms for regulating glucose allocation, one of which is sensory protein kinases. PAS kinase is a key sensory protein kinase that regulates glucose allocation in yeast, mice and man; and is a novel therapeutic target for the treatment of metabolic diseases such as obesity, diabetes and cancer. Despite its importance, the molecular mechanisms of PAS kinase function are largely unknown. Through large-scale protein-interaction studies

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39

Freitas, Claudia Mercedes. "Regulation of Immune Cell Activation and Functionby the nBMPp2 Protein andthe CD5 Co-Receptor." BYU ScholarsArchive, 2019. https://scholarsarchive.byu.edu/etd/8257.

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According to the centers for disease control and prevention (CDC) and the world healthorganization (WHO), heart disease and immune related diseases such as diabetes and cancer areamong the leading causes of death around the world. Thus, the regulation of the function ofimmune cell plays a key role in health and disease. Calcium (Ca2+) ions play a critical role inimmune cell activation, function and in a robust immune response. Defects in Ca2+ signalinginfluences the development of cardiac disease, Alzheimer disease, immune cell metabolism,muscle dysfunction, and cancer. Each immune cell is uni

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40

Häkkinen, Suvi T. "A functional genomics approach to the study of alkaloid biosynthesis and metabolism in Nicotiana tabacum and Hyoscyamus muticus cell cultures /." [Espoo, Finland] : VTT, 2008. http://www.vtt.fi/inf/pdf/publications/2008/P696.pdf.

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41

Vondracek, Martin. "Toxicity of smokeless tobacco in human oral epithelium with emphasis on carcinogen metabolism and regulation of programmed cell death /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-335-X/.

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42

Zhang, Wei. "Neurological - Molecular Interface in Food Intake and Metabolism in Birds and Mammals." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/64416.

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Abstract (sommario):

Obesity is a physiological consequence of dysregulated energy homeostasis. Energy homeostasis depends on energy intake and energy expenditure. Factors controlling the development of different adipose tissue deposits in the body and their distinct metabolic phenotypes are of considerable interest from both an agricultural and biomedical perspective. Following the literature review, the first chapter was devoted to studies designed to bridge the neural-adipose interface in understanding the relationship between appetite regulation and adipose tissue deposition in chickens, using chickens selecte

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43

Pan, Tien-Chien. "Metabolic, cardiac and ventilatory regulation in early larvae of the South African clawed frog, Xenopus laevis." Thesis, University of North Texas, 2009. https://digital.library.unt.edu/ark:/67531/metadc12175/.

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Early development of O2 chemoreception and hypoxic responses under normoxic (150 mmHg) and chronically hypoxic (110 mmHg) conditions were investigated in Xenopus laevis from hatching to 3 weeks post fertilization. Development, growth, O2 consumption, ventilatory and cardiac performance, and branchial neuroepithelial cells (NEC) density and size were determined. At 3 days post fertilization (dpf), larvae started gill ventilation at a rate of 28 ± 4 beats/min and showed increased frequency to 60 ± 2 beats/min at a PO2 of 30 mmHg. Also at 3 dpf, NECs were identified in the gill filament buds u

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44

Lekholm, Emilia. "Solute Carriers in Metabolism : Regulation of known and putative solute carriers in the central nervous system." Doctoral thesis, Uppsala universitet, Funktionell farmakologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-331328.

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Solute carriers (SLCs) are membrane-bound transporter proteins, important for nutrient, ion, drug and metabolite transport across membranes. A quarter of the human genome codes for membrane-bound proteins, and SLCs make up the largest group of transporter proteins. Due to their ability to transport a large repertoire of substances across, not just the plasma membrane, but also the membrane of internal organelles, they hold a key position in maintaining homeostasis affecting metabolic pathways. Unfortunately, some of the more than 400 identified SLCs are still not fully characterized, even thou

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45

Sun, Zheng Ernsberger Paul. "Imidazoline receptors in insulin signaling and metabolic regulation molecular basis for l1-imidazoline binding and cell signaling and the mechanisms linking this signaling protein to regulation glucose metabolism." Saarbrücken VDM Verlag Dr. Müller, 2007. http://d-nb.info/988497085/04.

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46

Wang, Sih-han. "Regulation of mitochondrial fates and cellular metabolism via parkin-mediated mitophagy and interaction between apoptosis and autophagy pathways in cancer." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/3400.

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Apoptosis is a cell death pathway that regulates tissue homeostasis, and is often altered in oncogenesis. Autophagy is a lysosome degradation pathway that mediates cellular adaptation in response to stresses. Altered autophagy pathways are proposed to be associated with pathogenesis of neurodegenerative diseases and oncogenesis. The goal of this work is to study the complex link between apoptosis and autophagy pathways, and their possible roles in the development of cancer. Using transgenic mice models, we found that impaired apoptosis by overexpression of a dominant negative form of Caspase-9

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47

Simon, Molas Helga. "Exploring the regulation and function of TIGAR in cancer cells." Doctoral thesis, Universitat de Barcelona, 2019. http://hdl.handle.net/10803/667414.

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The TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) gene was described in 2006 by Dr. Karen Vousden's group in response to the induction of the tumour suppressor gene p53. Since then, numerous studies have focused on clarifying the role of this gene in the metabolism of tumour cells. TIGAR was initially described as an enzyme with bisphosphatase activity on fructose-2,6-bisphosphate, a key metabolite in the positive allosteric regulation of phosphofructokinase-1, which catalyses a key reaction in glycolysis. Through this bisphosphatase activity, TIGAR reduces the levels of fructose-2,

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48

Niklas, Jens [Verfasser], and Elmar [Akademischer Betreuer] Heinzle. "Primary metabolism and its regulation in the human cell line AGE1.HN – application of metabolic flux analysis for improved biopharmaceutical production / Jens Niklas. Betreuer: Elmar Heinzle." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2012. http://d-nb.info/1052339573/34.

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49

Gaul, Susanne [Verfasser], Annette G. [Akademischer Betreuer] Beck-Sickinger, Annette G. [Gutachter] Beck-Sickinger, and Wieland [Gutachter] Kiess. "The NAMPT-mediated NAD salvage pathway in cancer cell metabolism and its regulation by resveratrol / Susanne Schuster ; Gutachter: Annette G. Beck-Sickinger, Wieland Kiess ; Betreuer: Annette G. Beck-Sickinger." Leipzig : Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-173401.

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50

Schuster, Susanne [Verfasser], Annette G. [Akademischer Betreuer] Beck-Sickinger, Annette G. [Gutachter] Beck-Sickinger, and Wieland [Gutachter] Kiess. "The NAMPT-mediated NAD salvage pathway in cancer cell metabolism and its regulation by resveratrol / Susanne Schuster ; Gutachter: Annette G. Beck-Sickinger, Wieland Kiess ; Betreuer: Annette G. Beck-Sickinger." Leipzig : Universitätsbibliothek Leipzig, 2015. http://d-nb.info/1239567219/34.

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