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1

Rodríguez, Javier, Signed Prieto, Milena Flórez, Claudia Alarcón, Ruth López, Gydnea Aguirre, Laura Pinilla, Omar Rovira e Laura Méndez. "Cardiac dynamic systems in normal neonates: Neonate chaotic cardiac law". Salud Uninorte 30, n. 3 (15 dicembre 2014): 361–70. http://dx.doi.org/10.14482/sun.30.3.5757.

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Debbal, Sidi. "Cardiac Severity Analysis". Journal of Thoracic Disease and Cardiothoracic Surgery 2, n. 2 (11 agosto 2021): 01–09. http://dx.doi.org/10.31579/2693-2156/023.

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Phonocardiogram (PCG) signal is a particular approach to explore cardiac activity, to develop technics that may serve medical staff to diagnose several cardiac diseases. We took advantage of PCG signal that shows heart murmurs on its tracing dissimilar to other cardiac signals, to design an algorithm to study and classify heart murmurs. In this paper, the importance is given to the severity of murmurs to highlight its impact, since depending on its stage the patient could be in life-threatening point; therefore, the purpose of this paper is focused on three essential steps: according to the algorithm, extracting murmurs and classifying them to deferent stages then investigate the impact of severity on cardiac frequency through some parameters. The severity stage calculation was based on energy ratio (ER) which is recommended by recent studies as an effective factor, however, we succeed to validate that murmur energy (ME) is also a qualified feature to determine severity. But despite that murmur duration, it's an inefficient way to judge the cardiac severity, which is a very important indicator of the general health of the human body. This study is done on considering many patients and it reveals very interesting results.
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Hashmi, Faiz, e Nikita Sharma. "Cardiac Nuclear Medicine". International Journal of Trend in Scientific Research and Development Volume-2, Issue-1 (31 dicembre 2017): 1235–42. http://dx.doi.org/10.31142/ijtsrd8212.

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Kisan, Chopade Dnyandeo, Parate Swapna, Gangane Suresh e Chopade Sandesh. "Cytogenetic Association of Cardiac and Non-Cardiac Anomalies in Down’s Syndrome". Indian Journal of Genetics and Molecular Research 7, n. 1 (2018): 5–11. http://dx.doi.org/10.21088/ijgmr.2319.4782.7118.1.

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Eun, Sung-Jong, e Jin-Sun Kook. "Evaluation of Cardiac Ejection Fraction using Cardiac MRI". Journal of the Korean Society of Radiology 5, n. 5 (31 ottobre 2011): 289–94. http://dx.doi.org/10.7742/jksr.2011.5.5.289.

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Jacome Ruiz, Pablo, e Christian Baquerizo Cardenas. "Monitor Cardíaco Portátil con Interfaz Bluetooth “CARDIO UEES” / Portable Heart Monitor with a Bluetooth Interface “CARDIO UEES”". Ciencia Unemi 9, n. 20 (20 dicembre 2016): 36. http://dx.doi.org/10.29076/issn.2528-7737vol9iss20.2016pp36-49p.

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En este trabajo se presenta el desarrollo e implementación de un monitor cardiaco capaz de cumplir con características de portabilidad, facilidad de uso y tiempo prolongado de operación. El diseño se divide en dos fases. En la primera, cada etapa del monitor cardiaco se implementa priorizando su consumo individual de energía. En la segunda fase, se integran las etapas para conformar el monitor cardiaco, constituido por una fuente de alimentación, una interfaz con el paciente, un micro controlador, una interfaz inalámbrica y una aplicación que se ejecuta en un teléfono inteligente. Para cumplir con las dos fases de diseño se exponen inicialmente los fundamentos teóricos y el desarrollo actual de la monitorización cardiaca. Posteriormente, para cada etapa se describen los requerimientos funcionales y las variables relevantes para su diseño. También se detallan los procesos de implementación y los procedimientos de prueba y sus resultados. Con esta investigación se pretende contribuir con una alternativa de diseño de un monitor cardiaco, que puede utilizarse por un periodo no menor a 30 días. Los resultados demostraron que el equipo desarrollado permite la monitorización cardiaca remota, facilita la movilidad de pacientes y además elimina la necesidad además elimina la necesidad de continuas recargas de energía. ABSTRACTThis paper describes the development and implementation of a heart monitor capable of meeting portability features, easy to use and a prolonged time of operation. The design is divided into two phases. In the first, each stage of the cardiac monitor is implemented prioritizing their individual energy consumption. In the second phase, the stages are integrated to form the cardiac monitor, consisting of a power supply, an interface with the patient, a micro controller, a wireless interface and an application running on a smartphone. To fulfill the two design phases are initially exposed the theoretical foundations and the current development of cardiac monitoring. Subsequently, for each stage, the functional requirements are described and the relevant variables for the design. Also, implementation processes and test procedures and results are detailed. This research is intended to contribute to an alternative design of a heart monitor, which can be used for not less than 30 days period. The results showed that the equipment developed allows remote cardiac monitoring, facilitates the mobility of patients and also eliminates the need for continuous energy refills.
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Patil, Amarjeet D., Sunita A. Patil, Vijay Bhola, Supriya Gokhale Gokhale e Charu Sudan Sudan. "SUCCINYLCHOLINE CAUSING CARDIAC ARREST". Asian Pacific Journal of Health Sciences 1, n. 2 (aprile 2014): 69–71. http://dx.doi.org/10.21276/apjhs.2014.1.2.6.

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Prasad, Arun, Sanjeev Kumar, Pradeep Kumar, Manju Kumari e Rajesh Kumar. "Cardiac Rhabdomyoma in Children". Indian Journal of Trauma and Emergency Pediatrics 10, n. 2 (2018): 49–51. http://dx.doi.org/10.21088/ijtep.2348.9987.10218.3.

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Geddes, L. A. "Fibrilacion — Defibrilacion cardiaca (Cardiac fibrillation and defibrillation)". Journal of Biomedical Engineering 9, n. 4 (ottobre 1987): 379–81. http://dx.doi.org/10.1016/0141-5425(87)90089-6.

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Sotoudehmanesh, Rasoul, e Mohamad Eloubeidi. "Cardia and cardiac tumor: endoscopic ultrasound video". Endoscopy 51, n. 09 (9 maggio 2019): E269–269. http://dx.doi.org/10.1055/a-0896-2657.

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Álvaro Vázquez Lopez-Cepero, Javier Iborra Escalona e Vicente Torres-Pedrós. "Dispositivos de asistencia mecánica circulatoria". Revista Electrónica AnestesiaR 10, n. 8 (31 agosto 2018): 3. http://dx.doi.org/10.30445/rear.v10i8.630.

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Un dispositivo de asistencia mecánica circulatoria o AMC, es una bomba con capacidad de dar soporte mecánico a un corazón en fallo cardiaco, facilitando el bombeo de la sangre desde las cavidades cardiacas hacia la circulación sistémica. Consideramos asistencia circulatoria a cualquier dispositivo o sistema utilizado para apoyar o sustituir la función cardiaca de forma temporal o, más raramente, permanente. Por norma general nos referimos a las asistencias ventriculares mecánicas y al corazón artificial total. ABSTRACT A mechanical circulatory assist devices (MCADs) , is a pump capable of giving mechanical support to a heart in heart failure, facilitating the pumping of blood from the cardiac cavities to the systemic circulation. We consider circulatory assistance to any device or system used to support or replace cardiac function temporarily or, more rarely, permanently. As a general rule, we refer to mechanical ventricular assist and total artificial heart.
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HASUI, Masahiro, Naoki MUKOUHARA, Morio MARUTANI, Naotsugu OHBAYASHI, Teruo SHRAKI, Shinji UCHIDA, Keiko IHARA et al. "A case of cardiac lipoma". Okayama Igakkai Zasshi (Journal of Okayama Medical Association) 102, n. 3-4 (1990): 319–23. http://dx.doi.org/10.4044/joma1947.102.3-4_319.

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Basanets, A. V., T. A. Ostapenko, V. V. Cherkesov e O. Y. Fartushna. "Sudden cardiac death at workplace". Ukrainian Journal of Occupational Health 2014, n. 2 (30 giugno 2014): 13–20. http://dx.doi.org/10.33573/ujoh2014.02.013.

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Jain, Dr Dharmendra, Dr Akash Kumar Pandey, Dr B. K. Das e Dr Rajniti Prasad. "Cardiac Function in Perinatal Asphyxia". Scholars Journal of Applied Medical Sciences 4, n. 7 (luglio 2016): 2718–28. http://dx.doi.org/10.21276/sjams.2016.4.7.87.

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Kumar P R, Nandeesh. "Cardiac Advanced Life Support (CALS)". International Journal of Science and Research (IJSR) 12, n. 9 (5 settembre 2023): 1183–87. http://dx.doi.org/10.21275/sr23914154445.

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Cindric Bogdan, Greta. "Cardiac Trauma (cardiac-pericardium tamponade)". Cardiologia Croatica 8, n. 10-11 (2 ottobre 2013): 331–44. http://dx.doi.org/10.15836/ccar.2013.331.

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Bougouin, Wulfran, e Alain Cariou. "Cardiac Issues in Cardiac Arrest". Seminars in Neurology 37, n. 01 (1 febbraio 2017): 013–18. http://dx.doi.org/10.1055/s-0036-1593861.

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Jagelavicius, Zymantas, Mindaugas Budra, Vytautas Jovaisas, Gintaras Kiskis, Algis Kybartas, Arunas Zilinskas, Irena Liubertiene, Vygantas Gruslys e Ricardas Janilionis. "CARDIAC SURGERY Penetrating cardiac injuries: 28-year data analysis". Polish Journal of Cardio-Thoracic Surgery 1 (2013): 1–7. http://dx.doi.org/10.5114/kitp.2013.34296.

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Tilling, Lindsey. "Hydroxychloroquine and risk of cardiac decompensation". International Journal of Clinical Case Reports and Reviews 4, n. 2 (6 novembre 2020): 01–03. http://dx.doi.org/10.31579/2690-4861/053.

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Background Hydroxychloroquine (HCQ) is a 4-aminoquinoline derivative, used in the treatment of malaria and rheumatic diseases. HCQ has also been suggested as a treatment in patients suffering from severe acute respiratory syndrome–coronavirus 2 (SARS–CoV-2). One of the cardiac complications of SARS-CoV-2 is myocarditis and ventricular dysfunction. Case summary We present the case of a 52 year old lady presenting with 2 months history of breathlessness, found to have severely impaired left ventricular function. She had been taking HCQ for 28 months for seronegative inflammatory arthritis. No cause was identified on initial investigation. She was treated with optimal medical therapy, and HCQ was stopped. After 5 months a cardiac MRI scan revealed full remodelling of the ventricle. Discussion This case highlights one of the lesser recognized side effects of HCQ, and the potential for severe cardiac dysfunction. As this drug continues to be investigated and used in the management of SARS-CoV-2 it is important to recognize the potential for cardiac decompensation in patients who are already at increased risk of myocardial dysfunction.
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Singh, Yashbir. "Machine Learning Integration in Cardiac Electrophysiology". Journal of Advanced Research in Dynamical and Control Systems 12, SP4 (31 marzo 2020): 942–44. http://dx.doi.org/10.5373/jardcs/v12sp4/20201565.

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Shi-Min Yuan, Shi-Min Yuan. "Acute Mesenteric Ischaemia Following Cardiac Operations". 童綜合醫學雜誌 16, n. 1 (giugno 2022): 001–7. http://dx.doi.org/10.53106/207135922022061601001.

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<p>Acute mesenteric ischaemia (AMI) is an uncommon but sometimes lethal sequel after heart operations. However, no definite diagnostic and therapeutic guidelines have been established so far. It has been reported that AMI occurs on postoperative day six after cardiac operation, with non-occlusive mesenteric ischaemia being the main mechanism leading to AMI. Furthermore, the treatment choices are primarily conservative, including angiography and papaverine infused at 30-60 mg/hour through an angiographic catheter. Others include fluid expansion and antibiotic and anticoagulant treatments. Nevertheless, urgent exploratory laparoscopy or even laparotomy is warranted for patients with peritoneal signs. The surgical principles for treating AMI are bowel resection, embolectomy/thrombectomy and endarterectomy with or without antegrade percutaneous stenting, aiming at restoring blood flow to the superior mesenteric artery. Still, the prognosis is poor, with an overall mortality rate of 71.8%. Therefore, an early suspicion leading to the diagnosis of postoperative AMI is crucial for improving patients&rsquo; outcomes.</p> <p>&nbsp;</p>
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Hussain, Md Sadique, e Swati Tyagi. "Cardiac Management in Covid-19 Patients". Pharmaceutics and Pharmacology Research 5, n. 6 (26 aprile 2022): 01–03. http://dx.doi.org/10.31579/2693-7247/081.

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Coronavirus disease 2019 (COVID-19) was initially identified in late December 2019 in Wuhan, China. COVID-19 has spreaded swiftly over the planet, becoming a global pandemic affecting over 200 nations and territories, having an extraordinary impact not only on public health but also on social and economic activity.
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Akhila, Chirukuri, Munjam Vaibhav Krishna e K. Ravinder Reddy. "An Unusual Case of Cardiac Tamponade". International Journal of Science and Research (IJSR) 12, n. 9 (5 settembre 2023): 1181–82. http://dx.doi.org/10.21275/sr23913081350.

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Toyoshima, Osamu, Toshihiro Nishizawa, Kosuke Sakitani, Tadahiro Yamakawa, Hidenobu Watanabe, Shuntaro Yoshida, Yousuke Nakai et al. "Nodularity-like appearance in the cardia: novel endoscopic findings for Helicobacter pylori infection". Endoscopy International Open 08, n. 06 (25 maggio 2020): E770—E774. http://dx.doi.org/10.1055/a-1136-9890.

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Abstract Background and study aims Helicobacter pylori-associated nodular gastritis, which is associated with follicular lymphoid hyperplasia, is mainly recognized in the antrum. However, we have also observed nodularity-like appearance in the cardia. This study aimed to investigate the clinical significance of cardiac nodularity-like appearance in H. pylori-associated gastritis. Patients and methods Patients who underwent esophagogastroduodenoscopy and were evaluated for H. pylori infection for the first time were enrolled. A nodularity-like appearance in the cardia was defined as a miliary nodular appearance or scattered appearances of small circular whitish coloration. H. pylori infection was diagnosed according to serum anti-H. pylori antibody and the urea breath test or histology. Accuracy of the H. pylori infection diagnoses based on nodularity-like appearance were assessed. Results Among 265 patients, 42 patients (15.8 %) were diagnosed as positive for H. pylori. Cardiac nodularity-like appearance and antral nodularity were recognized in 25 and 15 patients, respectively. In accuracy of predicting H. pylori by cardiac nodularity-like appearance, specificity was 0.996, sensitivity was 0.571, positive predictive value was 0.960, negative predictive value was 0.925, and accuracy was 0.928. The sensitivity of cardiac nodularity-like appearance was significantly higher than that of antral nodularity (P = 0.0284). Conclusions Cardiac nodularity-like appearance had a high accuracy rate for H. pylori infection diagnosis. Cardiac nodularity-like appearance was found more frequently than antral nodularity.
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M Nair, Mighila. "Effectiveness of Exercise Based Cardiac Rehabilitation on Selected Cardiac Parameters among Postoperated CABG Patient in Selected Hospital". Indian Journal of Surgical Nursing 9, n. 1 (1 aprile 2020): 31–36. http://dx.doi.org/10.21088/ijsn.2277.467x.9120.5.

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Murphy, Emily C., Lesley Cottrell, Alyson Ward, Valerie Minor, Eloise Elliott e William A. Neal. "CARDIAC". Medicine & Science in Sports & Exercise 39, Supplement (maggio 2007): S198. http://dx.doi.org/10.1249/01.mss.0000273739.36423.e1.

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Kampa, Courtney. "Cardiac". New England Review 33, n. 4 (2013): 102. http://dx.doi.org/10.1353/ner.2013.0001.

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Sherif, Khaled, Carlos Ceron Castro, Christian Avalos, Humberto Mochizuki Tamayo, Ruben Abreu e Y. Wady Aude. "CARDIAC HAMARTOMA: A RARE CARDIAC TUMOR". Journal of the American College of Cardiology 77, n. 18 (maggio 2021): 2597. http://dx.doi.org/10.1016/s0735-1097(21)03952-8.

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Kent, Elizabeth. "Chronic Cardiac Disease Chronic Cardiac Disease". Nursing Standard 17, n. 22 (12 febbraio 2003): 28. http://dx.doi.org/10.7748/ns2003.02.17.22.28.b331.

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Hopper, Ingrid. "Cardiac effects of non-cardiac drugs". Australian Prescriber 34, n. 2 (1 aprile 2011): 52–54. http://dx.doi.org/10.18773/austprescr.2011.030.

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Udzik, Jakub, Sandra Sienkiewicz, Andrzej Biskupski, Aleksandra Szylińska, Zuzanna Kowalska e Patrick Biskupski. "Cardiac Complications Following Cardiac Surgery Procedures". Journal of Clinical Medicine 9, n. 10 (18 ottobre 2020): 3347. http://dx.doi.org/10.3390/jcm9103347.

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Abstract (sommario):
Background: Elderly patients and those with multiple concomitant disorders are nowadays qualified for cardiac surgery procedures, which is related to higher incidence of the postoperative complications. Aim: The aim of this study was a retrospective analysis of the perioperative factors potentially contributing to occurrence of cardiac incidents after cardiac surgery procedures. Methods: Data of 552 patients of the cardiac surgery clinic were collected and analyzed. Data concerning medical history, previous treatment, laboratory results, additional tests results, operation and hospitalization period were examined. Results: In the study population of 552 patients, cardiac complications were observed in 49.5% of them. Among cardiac complications, the most frequent were supraventricular tachycardia (30.1%) and atrial fibrillation (27.4%). Postoperative bradycardia occurred in 5.25% patients, half of whom required temporary cardiac pacing. Conclusions: The risk of incidence of cardiac complications after cardiac surgery procedures depends mostly on patient’s age, EuroSCORE Logistic (ESL) score, left ventricular ejection fraction, myocardial hypertrophy, presence of paroxysmal AF and coincidence of nephrological complications. The necessity of performing more than one heart defibrillation after removing aortic cross-clamp favors early postoperative bradycardia. Considering the outcomes of this study, continuing reperfusion at least until 1/3 of the aortic cross-clamp time brings no additional benefits to the patients.
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CARROLL, P. V., V. MARKIDES e R. M. LEACH. "Localised cardiac tamponade following cardiac surgery". Clinical Intensive Care 7, n. 1 (febbraio 1996): 42–44. http://dx.doi.org/10.3109/tcic.7.1.42.44.

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Kass, David A. "Cardiac Resynchronization Therapy and Cardiac Reserve". Circulation 113, n. 7 (21 febbraio 2006): 923–25. http://dx.doi.org/10.1161/circulationaha.105.604603.

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Lindsey, Jennifer, e Richard B. Stacey. "Cardiac magnetic resonance in cardiac angiosarcoma". Echocardiography 34, n. 7 (29 giugno 2017): 1077–81. http://dx.doi.org/10.1111/echo.13598.

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Yamasaki, Yuzo, Mayumi Yoshikawa, Koji Sagiyama e Takeshi Kamitani. "Active Cardiac Sarcoidosis Imitating Cardiac Metastases". Radiology: Cardiothoracic Imaging 2, n. 6 (1 dicembre 2020): e200310. http://dx.doi.org/10.1148/ryct.2020200310.

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López-Herce, Jesús, e Jimena del Castillo. "Cardiac Arrest in Pediatric Cardiac ICUs". Pediatric Critical Care Medicine 18, n. 10 (ottobre 2017): 989–90. http://dx.doi.org/10.1097/pcc.0000000000001290.

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Abbas, A., K. A. G. Garfath-Cox, I. W. Brown, J. S. Shambrook, C. R. Peebles e S. P. Harden. "Cardiac MR assessment of cardiac myxomas". British Journal of Radiology 88, n. 1045 (gennaio 2015): 20140599. http://dx.doi.org/10.1259/bjr.20140599.

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Fukuda, Keiichi, Hideaki Kanazawa, Yoshiyasu Aizawa, Jeffrey L. Ardell e Kalyanam Shivkumar. "Cardiac Innervation and Sudden Cardiac Death". Circulation Research 116, n. 12 (5 giugno 2015): 2005–19. http://dx.doi.org/10.1161/circresaha.116.304679.

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Foëx, Bernard A., e Emyr W. Benbow. "Standby…cardiac arrest…standby…cardiac arrest*". Critical Care Medicine 34, n. 2 (febbraio 2006): 554–55. http://dx.doi.org/10.1097/01.ccm.0000196092.72359.21.

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Rokitansky, A., e E. Wolner. "Cardiac Support and Mechanical Cardiac Replacement". International Journal of Artificial Organs 14, n. 7 (luglio 1991): 387–92. http://dx.doi.org/10.1177/039139889101400701.

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Pennec, P. Y., e J. J. Blanc. "Cardiac lymphangioma: a benign cardiac tumour". European Heart Journal 27, n. 24 (7 aprile 2006): 2913. http://dx.doi.org/10.1093/eurheartj/ehl028.

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Sommers, Marilyn Sawyer. "Cardiac Tamponade After Nonpenetrating Cardiac Trauma". Dimensions of Critical Care Nursing 5, n. 4 (luglio 1986): 206–15. http://dx.doi.org/10.1097/00003465-198607000-00004.

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Eillis, Myra F. "Low Cardiac Output Following Cardiac Surgery". Dimensions of Critical Care Nursing 16, n. 1 (gennaio 1997): 48–55. http://dx.doi.org/10.1097/00003465-199701000-00010.

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Engle, Mary Allen. "Cardiac Surgery Without Preoperative Cardiac Catheterization". Pediatric Annals 16, n. 8 (1 agosto 1987): 623–28. http://dx.doi.org/10.3928/0090-4481-19870801-07.

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RADEMAKER, Miriam T., e A. Mark RICHARDS. "Cardiac natriuretic peptides for cardiac health". Clinical Science 108, n. 1 (15 dicembre 2004): 23–36. http://dx.doi.org/10.1042/cs20040253.

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Abstract (sommario):
The cardiac natriuretic peptides, ANP (atrial natriuretic peptide) and BNP (brain natriuretic peptide), are secreted by the heart in proportion to cardiac transmural pressures. They possess a wide range of effects in multiple tissues facilitating overall pressure/volume homoeostasis. The close relationship between plasma concentrations of these peptides and ‘cardiac load’ has led to their use as biomarkers of cardiac health with diagnostic and prognostic applications in a variety of disorders affecting the cardiovascular system. BNP and its N-terminal fragment (NT-BNP) are especially sensitive indicators of cardiac dysfunction and remodelling, and correlate strongly with severity. Given that cardiac ischaemia is also an important trigger for the release of these ventricular peptides, they may likewise play a role in the detection of coronary artery disease. Measurement of BNP/NT-BNP shows particular promise as a ‘rule out’ test for suspected cases of HF (heart failure) in both emergency care and outpatient settings, and may assist in identifying individuals with asymptomatic ventricular impairment who will benefit from therapy preventing progression to overt HF. The BNP peptides also predict subsequent haemodynamic deterioration and adverse events in cardiovascular disease, and can therefore be used to monitor those at high risk and act as a guide to optimization of treatment. The favourable biological properties of the natriuretic peptides have also led to their use as therapeutic agents.
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Mohsen, A., e K. El-Kersh. "Non-cardiac causes of cardiac tamponade". Case Reports 2013, sep13 2 (13 settembre 2013): bcr2013010170. http://dx.doi.org/10.1136/bcr-2013-010170.

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Florea, Viorel G., Michael Y. Henein, Mathias Rauchhaus, Veronika Koloczek, Rakesh Sharma, Wolfram Doehner, Philip A. Poole-Wilson, Andrew J. S. Coats e Stefan D. Anker. "The cardiac component of cardiac cachexia". American Heart Journal 144, n. 1 (luglio 2002): 45–50. http://dx.doi.org/10.1067/mhj.2002.123314.

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Anthi, Anastasia, George E. Tzelepis, Peter Alivizatos, Alkis Michails, George M. Palatianos e Stephanos Geroulanos. "Unexpected Cardiac Arrest After Cardiac Surgery". Chest 113, n. 1 (gennaio 1998): 15–19. http://dx.doi.org/10.1378/chest.113.1.15.

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Kron, Irving L., John A. Kern, George A. Beller, James Bergin, Steven M. Fiser, James J. Gangemi, John A. McPherson e Eric R. Powers. "Cardiac screening before non-cardiac operations". Current Problems in Surgery 37, n. 6 (giugno 2000): 385–454. http://dx.doi.org/10.1016/s0011-3840(00)80008-8.

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Reddy, V. Seenu, Ho H. Phan, Richard N. Pierson, Davis C. Drinkwater, Paul A. Chang, Stacy F. Davis e Walter H. Merrill. "Late cardiac reoperation after cardiac transplantation". Annals of Thoracic Surgery 73, n. 2 (febbraio 2002): 534–37. http://dx.doi.org/10.1016/s0003-4975(01)03337-9.

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