Bibliografie tematiche / Cancer – Genetic aspects

Letteratura scientifica selezionata sul tema "Cancer – Genetic aspects"

Autore: Grafiati
Pubblicato: 4 giugno 2021
Ultima modifica: 20 febbraio 2023

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Articoli di riviste sul tema "Cancer – Genetic aspects"

1

Hold, Georgina L., e M. Emad El-Omar. "Genetic aspects of inflammation and cancer". Biochemical Journal 410, n. 2 (12 febbraio 2008): 225–35. http://dx.doi.org/10.1042/bj20071341.

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Chronic inflammation is involved in the pathogenesis of most common cancers. The aetiology of the inflammation is varied and includes microbial, chemical and physical agents. The chronically inflamed milieu is awash with pro-inflammatory cytokines and is characterized by the activation of signalling pathways that cross-talk between inflammation and carcinogenesis. Many of the factors involved in chronic inflammation play a dual role in the process, promoting neoplastic progression but also facilitating cancer prevention. A comprehensive understanding of the molecular and cellular inflammatory mechanisms involved is vital for developing preventive and therapeutic strategies against cancer. The purpose of the present review is to evaluate the mechanistic pathways that underlie chronic inflammation and cancer with particular emphasis on the role of host genetic factors that increase the risk of carcinogenesis.
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Hudler, Petra. "Genetic Aspects of Gastric Cancer Instability". Scientific World Journal 2012 (2012): 1–10. http://dx.doi.org/10.1100/2012/761909.

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Unravelling the molecular mechanisms underlying gastric carcinogenesis is one of the major challenges in cancer genomics. Gastric cancer is a very complex and heterogeneous disease, and although much has been learned about the different genetic changes that eventually lead to its development, the detailed mechanisms still remain unclear. Malignant transformation of gastric cells is the consequence of a multistep process involving different genetic and epigenetic changes in numerous genes in combination with host genetic background and environmental factors. The majority of gastric adenocarcinomas are characterized by genetic instability, either microsatellite instability (MSI) or chromosomal instability (CIN). It is believed that chromosome destabilizations occur early in tumour progression. This paper summarizes the most common genetic alterations leading to instability in sporadic gastric cancers and its consequences.
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Olsson, R. "Hepatitis and Cancer: Genetic Aspects". Scandinavian Journal of Gastroenterology 31, sup220 (gennaio 1996): 115–20. http://dx.doi.org/10.3109/00365529609094761.

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R., Bohiltea. "Genetic aspects of endometrial cancer". Gineco.eu 12, n. 1 (20 marzo 2016): 29–32. http://dx.doi.org/10.18643/gieu.2016.29.

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Karlan, Beth Y., e Deborah Krakow. "Genetic aspects of ovarian cancer". Current Opinion in Obstetrics and Gynecology 6, n. 1 (febbraio 1994): 105. http://dx.doi.org/10.1097/00001703-199402000-00017.

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Steel, M., A. Thompson e J. Clayton. "Genetic aspects of breast cancer". British Medical Bulletin 47, n. 2 (1991): 504–18. http://dx.doi.org/10.1093/oxfordjournals.bmb.a072488.

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Latil, Alain, e R. Lidereau. "Genetic aspects of prostate cancer". Virchows Archiv 432, n. 5 (19 maggio 1998): 389–406. http://dx.doi.org/10.1007/s004280050183.

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Hecht, Jonathan L., e George L. Mutter. "Molecular and Pathologic Aspects of Endometrial Carcinogenesis". Journal of Clinical Oncology 24, n. 29 (10 ottobre 2006): 4783–91. http://dx.doi.org/10.1200/jco.2006.06.7173.

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Abstract (sommario):
Endometrial cancer is the most common gynecological malignancy, with 41,000 new cases projected in the United States for 2006. Two different clinicopathologic subtypes are recognized: the estrogen-related (type I, endometrioid) and the non–estrogen-related types (type II, nonendometrioid such as papillary serous and clear cell). The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy and p53 mutations. This article reviews the genetic aspects of endometrial carcinogenesis and progression. We will define the precursor lesion of type I endometrioid cancer and the role of genetics and estrogen in its progression.
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Hill, R. P. "Genetic aspects of metastasis". Current Opinion in ONCOLOGY 2, n. 1 (febbraio 1990): 157–62. http://dx.doi.org/10.1097/00001622-199002000-00026.

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Krasteva, M., Sv Angelova e Zl Gospodinova. "Molecular-Genetic Aspects of Breast Cancer". Acta Medica Bulgarica 41, n. 2 (1 dicembre 2014): 67–79. http://dx.doi.org/10.1515/amb-2014-0024.

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Summary Breast cancer is the most frequent malignancy among women. Advances in breast cancer knowledge have deciphered the involvement of a number of tumor suppressor genes and proto-oncogenes in disease pathogenesis. These genes are part of the complex biochemical pathways, which enable cell cycle control and maintenance of genome integrity. Their function may be disrupted as a result of alterations in gene sequence or misregulation of gene expression including alterations in DNA methylation pattern. The present review summarizes the main findings on major breast cancer related genes BRCA1/2, p53, ATM, CHEK2, HER2, PIK3CA and their tumorigenic inactivation/activation. The potential clinical importance of these genes with respect to patients’ prognosis and therapy are also discussed. The possible implication of other putative breast cancer related genes is also outlined. The first elaborate data on the genetic and epigenetic status of the above mentioned genes concerning Bulgarian patients with the sporadic form of the disease are presented. The studies indicate for a characteristic mutational spectrum in some of the genes for the Bulgarian patients and specific correlation between the status of different genes and clinicopathological characteristics.
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Tesi sul tema "Cancer – Genetic aspects"

1

Fransén, Karin. "Molecular genetic aspects of colorectal cancer development /". Linköping : Univ, 2005. http://www.bibl.liu.se/liupubl/disp/disp2005/med878s.pdf.

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Steggles, Naomi. "Psychological aspects of genetic testing for cancer". Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271020.

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Cheung, Chin-ling, e 張展寧. "Genetic analysis of nasopharyngeal cancer". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44659866.

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Hayat, Roshanai Afsaneh. "Psychological and Behavioral Aspects of Receiving Genetic Counseling for Hereditary Cancer". Doctoral thesis, Uppsala universitet, Vårdvetenskap, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-128870.

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The overall aims of this thesis were to investigate psychological and behavioral effects of receiving cancer genetic counseling for breast, ovarian and colorectal cancer and/or with a family history of these cancer types and to determine whether counselees’ informational needs were met. Study I was performed 3-7 years post-counseling. Participants (n=214) reported a relatively high level of anxiety but a low level of depression compared to cancer patients in general. However, there was no indication that the distress experienced was due to the counseling. Moderate changes in life and family relations, high level of adherence to recommended controls and satisfaction was reported. Study II was a randomized control trial (RCT) intervention study which involved 147 counselees. An increase in the level of knowledge and correct estimation of personal risk was reported in both the intervention and control groups, although this increase declined at later follow-up. Enhanced information led to significantly greater satisfaction with the given information, and the way of informing relatives. Most counselees had shared information with their at-risk relatives. Study III focused on sharing information with at-risk relatives among participants in study II and their relatives (n=81). Counselees were interviewed and answered a questionnaire, whilst their relatives only answered the questionnaire. Counselees reported positive/neutral feelings about communicating genetic information and mostly interpreted their relatives’ reactions as positive/ neutral. Also, approximately 50% of relatives reported positive/neutral reactions and were generally satisfied with the received information. Study IV was conducted in Sweden and Norway based on 235 counselees. Counselees expected counselors to be skillful and thoughtful, take them seriously and provide risk estimations and medical information. Most important issues to counselees were satisfactorily addressed by the counselors. Analyzing importance rankings resulted in five categories of needs: a need for facts, caring communication and medical information, need for understanding and support in sharing genetic information, practical care and medical/practical information. In conclusion, no adverse psychological or behavioral effect on counselees was observed. Apparently, genetic counseling is managed properly and counselors successfully address counselees’ needs. Providing extended information does not seem necessary, however, tailoring information to individual counselees needs may create a more effective counseling.
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陳安安 e On-on Annie Chan. "Methylation in colorectal cancer". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B25256312.

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Tai, Lai-shan, e 戴麗珊. "Molecular genetic characterizations of human non-small cell lung cancer". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31375315.

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Zhao, Wei, e 趙煒. "BRAF mutation and aberrant methylation of gene promoters in the pathogenesis of gastrointestinal tract adenocarcinoma". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B36718464.

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Wright, C. M. "The prognostic significance of microsatellite instability in sporadic stage C colorectal cancer". Thesis, The University of Sydney, 2008. https://hdl.handle.net/2123/28955.

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Identification and understanding of the molecular events involved in colorectal cancer (CRC) pathogenesis should lead to better comprehension of the disease process, hopefully leading to better prognostic stratification, and as a result more targeted treatment regimens and improved patient outcomes. A sub group of sporadic CRC exhibit microsatellite instability (MSI). MSI is seen when the fidelity of DNA replication is impaired. Cancers may be categorized as MSI-high (MSI-H), MSI-low (MSI-L), or microsatellite stable (MSS), according to the degree of MSI exhibited. This research project was designed to analyse the association between MSI—H and MSI-L, clinicopathological features and survival in an unselected group of patients with sporadic Australian Clinicopathological Stage (ACPS) C / American Joint Committee on Cancer (AJCC) stage III CRC, i.e. patients with lymph node metastases at the time of surgical resection of their cancer. The criteria used to determine MSI, specifically the type and number of microsatellite markers used, were also reviewed. 255 patients who underwent resection for sporadic ACPS stage C CRC were studied; none of these patients received chemotherapy. Archival normal and tumour DNA were extracted and amplified by polymerase chain reaction using a radioactive-labelling technique and a panel of internationally recognised microsatellite markers. MSI-H was defined as instability in 2 40% of 7 markers, MSI-L as instability at > 0% but < 40% of 11 markers, and M88 as no instability. Twenty one MSI-H and 33 MSI-L CRC were identified. Significant results included that MSI-H tumours are more commonly right sided (p < 0.00001); larger (p 5 0.0005); more likely to be high grade (p = 0.049); and, after adjustment for age, sex and other pathology variables, associated with improved survival (p = 0.015). No difference was found between the biological characteristics of MSI-L and MSS CRC. MSI-L CRC showed a trend towards poorer cancer-specific survival than MSS CRC but this difference did not reach statistical significance. Although dependent on the number and type of microsatellites used, similar trends in the results were seen when different criteria were used to determine MSI. This study has contributed to the rapidly expanding literature on CRC carcinogenesis and, at the time completed, was one of the first to show an association between MSI-H and improved survival in clinicopathological stage C CRC patients who had not received chemotherapy. It supports the view that identification of MSI status in patients with sporadic ACPS C / AJCC stage III tumours may help stratify patients according to prognosis and should be considered in therapeutic decision making and future trials of adjuvant therapy. However to accurately determine the clinical usefulness of MSI more precise standardisation of the definition and methodologies used to identify M81 is required.
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黃鳳如 e Fung-yu Huang. "Molecular and cytogenetic analysis of cervical and vulvar cancer". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B26662188.

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Khoo, Ui-soon, e 邱瑋璇. "Genetic susceptibility to gynaecological cancers in the Chinese population". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B25257365.

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Libri sul tema "Cancer – Genetic aspects"

1

Cancer genetics. New York: Springer, 2010.

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Principles of cancer genetics. Dordrecht: Springer, 2008.

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Côté, Gilbert B. Cancer cytogenetics lookup. Ontario, Canada: Canell, 1999.

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1959-, Eeles Rosalind A., a cura di. Genetic predisposition to cancer. London: Chapman & Hall Medical, 1996.

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Genetic recombination in cancer. Amsterdam: Academic Press, 2003.

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Genetic susceptibility to cancer. Boston: Kluwer Academic, 1998.

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Biology of cancer: Cancer genetics. New York NY: Chelsea House, 2007.

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Chung, Daniel C., e Daniel A. Haber. Principles of clinical cancer genetics: A handbook from the Massachusetts General Hospital. A cura di Massachusetts General Hospital. New York: Springer, 2010.

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W, Weber, Mulvihill John J. 1943- e Narod Steven A, a cura di. Familial cancer management. Boca Raton: CRC Press, 1996.

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National Institutes of Health (U.S.), a cura di. The genetics of cancer. Bethesda, MD: U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, 1990.

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Capitoli di libri sul tema "Cancer – Genetic aspects"

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Goddard, Audrey D., e Ellen Solomon. "Genetic Aspects of Cancer". In Advances in Human Genetics 21, 321–76. Boston, MA: Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-3010-7_4.

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Chichakli, Ramsey N., e Jeffrey R. Gingrich. "Genetic Aspects of Urologic Malignancies". In Inherited Cancer Syndromes, 205–40. New York, NY: Springer New York, 2004. http://dx.doi.org/10.1007/0-387-21596-4_9.

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Sobels, F. H. "Genetic Aspects of Cancer Epidemiology". In Antimutagenesis and Anticarcinogenesis Mechanisms, 459–63. Boston, MA: Springer US, 1986. http://dx.doi.org/10.1007/978-1-4684-5182-5_40.

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MacKay, J., e M. Steel. "Genetic Aspects of Human Breast Cancer". In High-Risk Breast Cancer, 45–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-73718-3_3.

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Greene, M. H., e S. J. Bale. "Genetic Aspects of Cutaneous Malignant Melanoma". In Recent Results in Cancer Research, 144–53. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-82641-2_12.

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Yaghmaie, Marjan, Mohammad Ahmadvand, Ali-akbar Nejati Safa e Hossein Pashaiefar. "Genetic, Hematologic and Psychological Aspects of Leukemia". In Cancer Genetics and Psychotherapy, 667–755. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-64550-6_14.

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Aspinwall, Lisa G., Jennifer M. Taber, Wendy Kohlmann e Sancy A. Leachman. "Psychological Aspects of Hereditary Cancer Risk Counseling and Genetic Testing". In Psychological Aspects of Cancer, 31–64. Boston, MA: Springer US, 2012. http://dx.doi.org/10.1007/978-1-4614-4866-2_3.

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Backer, J. M., e C. V. Hamby. "Genetic control of metastasis". In Molecular Aspects of Cancer and its Therapy, 1–19. Basel: Birkhäuser Basel, 1998. http://dx.doi.org/10.1007/978-3-0348-8946-9_1.

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Sobti, R. C., Adnan Issa AL-Badran, Khadijeh Onsori e S. K. Sharma. "Bladder Cancer: Genetic and Epidemiological Factors Involved in its Genesis". In Some Aspects of Chromosome Structure and Functions, 207–24. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-010-0334-6_19.

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McIvor, R. Scott. "Gene Therapy for Genetic Disease and Cancer". In Animal Cell Technology: Basic & Applied Aspects, 7–12. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-017-0728-2_2.

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Atti di convegni sul tema "Cancer – Genetic aspects"

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Rotaru, Ludmila, e Tudor Rotaru. "Ovarian cancer – genetic aspects". In XIth International Congress of Geneticists and Breeders from the Republic of Moldova. Scientific Association of Geneticists and Breeders of the Republic of Moldova, Institute of Genetics, Physiology and Plant Protection, Moldova State University, 2021. http://dx.doi.org/10.53040/cga11.2021.041.

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Mishatkina, T. V., S. B. Melnov e E. V. Snytkov. "GENETIC AND SOCIO-BIOETHICAL ASPECTS OF BREAST CANCER PREDISPOSITION AMONG WOMEN OF SLAVIC AND CENTRAL ASIAN ETHNIC GROUPS". In SAKHAROV READINGS 2021: ENVIRONMENTAL PROBLEMS OF THE XXI CENTURY. International Sakharov Environmental Institute, 2021. http://dx.doi.org/10.46646/sakh-2021-1-64-68.

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The publication was prepared based on the materials of the implementation of the joint Belarusian-Uzbek two-year scientific project “Genetic and socio-bioethical aspects of predisposition to breast cancer for women of Slavic and Central Asian ethnic groups.” The results of studies carried out from October 01, 2020 to March 15, 2021 are presented.
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Ferreira, Nancy, Darley Ferreira e Thais Ferreira. "GENETIC EVALUATION OF MICROCALCIFICATIONS AS A PROGNOSTIC FACTOR". In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2101.

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Introduction: Breast cancer is the most recurring type of cancer among women, with reduced mortality at an initial stage of lesion. From a radiological perspective, perceived microcalcifications may be associated with histological findings such as proliferative injuries with or without atypical features and ductal carcinoma in situ. Currently, percutaneous and vacuum biopsies allow for the correlation between anatomoradiological and identification of previous lesions and those that offer the risk of cancer. No biomarker has been established to predict the risk of cancer in women diagnosed with benign mammary disease. Doing so could strengthen the possibility of stratifying the individual risk of benign injuries for cancer. The platelet-derived growth factor receptor A (PDGFRA) plays its part in tumor oncogenesis, angiogenesis, and metastasis, and its activation is found in some kinds of cancer. In contrast, DNA methylation standards are initial changes to the development of cancer and may be helpful in its early identification, being regulated by a family of enzymes called DNMTs (DNA methyltransferase). Methods: The aim of this study was to evaluate the profile of BI-RADS® 4 and 5 mammary microcalcification women carriers and determine the level of the gene expression of possible molecular markers in 37 patients with mammary microcalcification (paraffin blocks) and 26 patients with breast cancer (fresh in RNA later tissue) cared for at the Hospital Barão de Lucena’s Mastology Ambulatory. Anatomoradiological aspects along with clinical findings have been evaluated , and percentage rates have been calculated. The PDGFRA and DNMTs (DMNT3a) gene expressions have been established using quantitative polymerase chain reaction (qPCR), with the use of β-actin as reference gene. Discussion: In the patients with mammary microcalcification, the average age was 55.9; predominantly whiteskinned subjects (p<0.014). Most of them were mothers (p<0.001), and the average menarche age was 13. The subgroups that presented greater significance were patients classified BI-RADS® in category IV (67.6%) and histological findings of nonproliferative lesion (p<0.001). Lesions of the ductal carcinoma in situ type (100%) presented positive estrogen and progesterone receptors, and 94.6% have undergone sectorectomy surgery by prior needling (p<0.001). The most damaged breast was the left one (62.2%), and the most affected quadrant was the top lateral one (59.5%) (p<0.001). There was no family history in 83.8% of the cases. In the tested microcalcification samples, it was not possible to observe the expression of PDGFRA. Nevertheless, 15 out of 37 patients with microcalcification showed an increase in the gene expression of DMNT3a, most of them greater than Luminal and triple-negative cancer types. Conclusion: The data presented here highlight the improvement on the description of BI-RADS® 4 subclassification in order to better conduct the clinical decision and also demonstrated the potential of DNMTs evaluation in microcalcification samples as a strategy to access the understanding about the role of these molecules in the breast cancer development.
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Assis, Amilcar Alves, Mauro Passos, Rodrigo Kouzak, Karoline Evangelista e Natasha Caldas. "BREAST CANCER IN YOUNG PATIENTS: PROGNOSTIC AND PROFILE EPIDEMIOLOGICAL ANALYSIS IN A TERTIARY HOSPITAL". In Abstracts from the Brazilian Breast Cancer Symposium - BBCS 2021. Mastology, 2021. http://dx.doi.org/10.29289/259453942021v31s2093.

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Abstract (sommario):
Breast cancer is the second most prevalent and first in mortality in Brazilian women. Its incidence has increased in recent years in all age groups. According to the Instituto Nacional do Câncer in 2019, 59,700 new cases of breast cancer are expected, with an estimated risk of 56.33 cases per 100 women. The diagnosis of breast cancer is more frequent in women after 50 years of age; it is estimated that only 25% of all cases occur in women below the age of 50 years; however, there was a literature consensus that tumors in this young age group have a worse prognosis, both because they are biologically more aggressive and because of affect women outside the screening age group in Brazil; thus, the rate of locally advanced disease at diagnosis in this age group is considerably higher. It is suggested that early onset breast cancer is related to different etiological factors, histopathological aspects, and clinical outcomes, as compared to postmenopausal breast cancer. Thus, age becomes an important prognostic factor. Since breast cancer is a curable pathology, the type of therapeutic approach also varies, with proposed treatment tends to be more aggressive. With the advent and increasing availability of genetic tests, predisposition of breast cancer has increased the number of indications for prophylactic mastectomies, especially in younger age groups or notably in patients with known pathological mutations in BRCA1 and BRCA2 genes. However, the literature is still controversial regarding its impact on overall survival. Breast cancer diagnosed before the age of 50 years is a behavioral disease, with prognosis and approach very different from that diagnosed in postmenopausal women. Therefore, it is important to know the profile of these patients to provide optimal treatment and achieve the best outcomes.
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Kumar, N., A. Mishra e S. Deo. "169 A prospective interventional study evaluating awareness and knowledge about genetic aspects of breast cancer and the effect of educational intervention: a real-life experience". In IGCS 2020 Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2020. http://dx.doi.org/10.1136/ijgc-2020-igcs.147.

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Руда, М. Г. "Legal regulation of the use of biological collections as a "pillar" of genetic research". In XXIII Международная научная конференция «Цивилизация знаний: российские реалии» «Цивилизационные задачи современного правоведения: наука, образование, практика» (стратегическая панель). Crossref, 2022. http://dx.doi.org/10.18137/cz22.2022.65.55.001.

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В статье рассматриваются изменения, произошедшие под воздействием механизмов глобализации и интеграции. В первую очередь, это отразилось в изменении вектора эволюции основных тенденций использования материала биологических коллекций как «фундамента» генетических исследований в различных областях науки и практики. К ним относятся, в частности, исследования биологического разнообразия и оценка негативного антропогенного воздействия на окружающую среду. Кроме того, с помощью прогностического, статистического и аксиологического методов сделан ряд важных выводов о возможных последствиях такого воздействия и путях его минимизации. Эти выводы следуют из анализа перечня сопутствующих факторов: социологического, экономического, политического. Более того, изучено влияние данных аспектов на реализацию таких базовых прав человека, как право на получение достоверной информации и право на благоприятную окружающую среду, которые, в свою очередь тесно взаимосвязаны с реализацией государственными органами мероприятий, направленных на повышение качества и уровня жизни населения Российской Федерации. Кроме того, коллекции также рассмотрены как основной источник информации в палеонтологических, археологических, селекционных исследованиях, которые позволяют в долгосрочной перспективе обеспечить биологическую и продовольственную безопасность и эффективное развитие аграрно-промышленного комплекса РФ. Необходимо также отметить стремительно растущий потенциал коллекций биологического материала человека в генетической генеалогии, исследовании ряда заболеваний (например, онкологических), а также механизма генетического редактирования CRISPR CaS-9, так называемых «генетических ножниц». The article deals with the changes that have taken place under the influence of globalization and integration mechanisms. First of all, it is reflected in the change of the vector of evolution of the main trends in the use of biological collections as the "foundation" of genetic research in various fields of science and practice. These include, in particular, studies of biodiversity and assessment of the negative anthropogenic impact on the environment. In addition, using predictive, statistical, and axiological methods, a number of important conclusions about the possible consequences of such impacts and the ways to minimize them are made. These conclusions follow from the analysis of the list of related factors: sociological, economic, political. Moreover, the influence of these aspects on the realization of such basic human rights as the right to reliable information and the right to a favorable environment, which, in turn, are closely interconnected with the implementation by state authorities of measures aimed at improving the quality and standard of living of the population of the Russian Federation, is studied. Besides, the collections are also considered as the main source of information in paleontological, archeological, breeding studies, which allow in the long term to ensure biological and food security and effective development of the agricultural complex of the Russian Federation. It is also necessary to note the rapidly growing potential of collections of human biological material in genetic genealogy, the study of a number of diseases (e.g., cancer), as well as the mechanism of CRISPR CaS-9 genetic editing, the so-called "genetic scissors".
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Sato, Misako, Mitsutaka Kadota, Binwu Tang, Yu-an Yang, Mengge Shan, Jia Weng, Michael Welsh et al. "Abstract B029: Dissecting out the tumor suppressor aspect of TGF-β in breast cancer using integrated genomics". In Abstracts: AACR Special Conference on Advances in Breast Cancer Research: Genetics, Biology, and Clinical Applications - October 3-6, 2013; San Diego, CA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1557-3125.advbc-b029.

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Zhang, Xue-Qing, Mark Chen, Robert Lam, Xiaoyang Xu, Eiji Osawa e Dean Ho. "A Platform Approach to Gene Delivery via Surface Modified Nanodiamonds". In ASME 2010 First Global Congress on NanoEngineering for Medicine and Biology. ASMEDC, 2010. http://dx.doi.org/10.1115/nemb2010-13340.

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The purpose of gene therapy is to introduce foreign genetic material into host cells to either supplement aberrant genes or to endow additional biological functions. To date, however, there has been only modest progress towards this goal, mainly due to the lack of safe, effective and broadly applicable delivery methods. Functional nanodiamonds (NDs) are rapidly emerging as promising platform carriers for next-generation therapeutics due to their innate biocompatibility, scalability, precise particle distribution, high surface area-to-volume ratio, near-spherical aspect ratio, and easily adaptable carbon surface for bioagent attachment. NDs have been functionalized with a range of therapeutics, proteins, antibodies, DNA, polymers, and other assorted biological agents. Furthermore, NDs are stable and dispersible in water, making them a promising and clinically important modality in improving the efficacy of the treatment of diseases and even some cancers at the molecular level. Mitochondrial function (MTT) and luminescent ATP production assays have demonstrated that NDs are not toxic to a wide variety of cell types. In this study, we functionalized NDs with amine groups via either covalent attachment of (3-aminopropyl) trimethoxysilane or surface immobilization of 800 Da low molecular weight polyethyleneimine (LMW PEI800) for plasmid DNA delivery. The latter delivery approach combines complementary characteristics of PEI800 and NDs to create a hybrid material that exhibits the high transfection efficiency of high molecular weight PEI, but without the inherent high cytotoxicity.
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