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1

Willgert, Katriina, Susie da Silva, Ruoran Li, Premanshu Dandapat, Maroudam Veerasami, Hindol Maity, Mohan Papanna et al. "Is bovine density and ownership associated with human tuberculosis in India?" PLOS ONE 18, n. 3 (22 marzo 2023): e0283357. http://dx.doi.org/10.1371/journal.pone.0283357.

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Abstract (sommario):
Zoonotic tuberculosis in humans is caused by infection with bacteria of the Mycobacterium tuberculosis complex acquired from animals, most commonly cattle. India has the highest burden of human tuberculosis in the world and any zoonotic risk posed by tuberculosis in bovines needs to be managed at the source of infection as a part of efforts to end human tuberculosis. Zoonotic tuberculosis in humans can be severe and is clinically indistinguishable from non-zoonotic tuberculosis. As a consequence, zoonotic tuberculosis remains under-recognised and the significance of its contribution to human tuberculosis is poorly understood. This study aimed to explore any association between bovine density, bovine ownership, and human tuberculosis reporting in India using self-reported tuberculosis data in households and officially reported tuberculosis cases while controlling for common confounders for human tuberculosis. We find an association between human tuberculosis reporting, bovine density and bovine ownership in India. Buffalo density was significantly associated with an increased risk of self-reported tuberculosis in households (odds ratio (OR) = 1.23 (95% credible interval (CI): 1.10–1.39) at household level; incidence rate ratio (IRR) = 1.17 (95% CI: 1.04–1.33) at district level), while cattle density (OR = 0.80, 95% CI: 0.71–0.89; IRR = 0.78, 95% CI: 0.70–0.87) and ownership of bovines in households (OR = 0.94, 95% CI: 0.9–0.99; IRR = 0.67, 95% CI: 0.57–0.79) had a protective association with tuberculosis reporting. It is unclear whether this relates to differences in tuberculosis transmission dynamics, or perhaps an association between bovines and other unexplored confounders for tuberculosis reporting in humans. Our study highlights a need for structured surveillance to estimate the prevalence of tuberculosis in cattle and buffaloes, characterisation of Mycobacterium tuberculosis complex species present in bovines and transmission analyses at the human-animal interface to better assess the burden and risk pathways of zoonotic tuberculosis in India.
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2

Pandey, G., S. Dhakal, A. Sadaula, G. KC, S. Subedi, KR Pandey e IP Dhakal. "Status of tuberculosis in bovine animals raised by tuberculosis infected patients in Western Chitwan, Nepal". International Journal of Infection and Microbiology 1, n. 2 (20 gennaio 2013): 49–53. http://dx.doi.org/10.3126/ijim.v1i2.7407.

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INTRODUCTION: Bovine tuberculosis (bTB) is an important public health concern worldwide. This study was conducted to determine the status of bTB in animals raised by tuberculosis patients in Western Chitwan, Nepal. MATERIALS AND METHODS: This cross-sectional study was conducted from August, 2011 to January, 2012. A total of 100 bovines (cattle and buffalo) raised in 60 farms of tuberculosis patients were tested with single intradermal tuberculin test considering various animal factors. Well designed questionnaire survey was taken with 70 tuberculosis patients of same 60 families focusing knowledge, awareness and various practices related to bovine tuberculosis. RESULTS: Overall 15% bovines were positive for tuberculosis (13.6% cattle and 15.4% buffaloes). Age of animal was significantly associated with tuberculosis (p<0.05) while sex and species were not. 24% tuberculosis patients had raw milk consuming habit while very few of them (9%) were aware of zoonotic aspect of bovine tuberculosis. CONCLUSIONS: There is high chance of tuberculosis transmission form animals to humans or vice versa. Further detailed study is needed in large scale with stronger intersectoral collaboration of medical and veterinary health sector to determine the scale of problem and find out prevention and control strategies against zoonotic tuberculosis. DOI: http://dx.doi.org/10.3126/ijim.v1i2.7407 Int J Infect Microbiol 2012;1(1):49-53
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3

Ejeh, E. F., M. A. Raji, M. Bello, F. A. Lawan, M. I. Francis, A. C. Kudi e S. I. B. Cadmus. "Prevalence and Direct Economic Losses from Bovine Tuberculosis in Makurdi, Nigeria". Veterinary Medicine International 2014 (2014): 1–6. http://dx.doi.org/10.1155/2014/904861.

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A retrospective study was conducted to investigate the prevalence of bovine tuberculosis and direct economic losses (DEL) from tuberculosis in cattle slaughtered in Makurdi abattoirs from 2008 to 2012, using abattoir records obtained from the Ministry of Agriculture and Natural Resources. Out of 61654 cattle slaughtered during the study period 1172 (1.90%) were positive for tuberculosis lesions. The annual prevalence of bovine tuberculosis ranges from 0.90% in 2008 to 4.04% in 2012. There was significant (P<0.05) difference in annual prevalence of bovine tuberculosis. It was also observed that there was no seasonal difference in the prevalence of bovine tuberculosis. A total of 1935 affected organs by BTB weighing 3046.50 kg, amounting to 2.91 × 106 Naira (1.82 × 104 USD), were condemned within the study period. Seasonal variation in organ condemnation due to bovine tuberculosis was significantly different (Mann-WhitneyUstatistics = 774 × 103,P=0.034). It was concluded that bovine tuberculosis is prevalent in Makurdi and accounts for heavy economic losses due to condemnation of edible organs.
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4

Khairullah, Aswin, Ikechukwu Moses, Muhammad Kusala, Wiwiek Tyasningsih, Siti Ayuti, Fedik Rantam, Ima Fauziah et al. "Unveiling insights into bovine tuberculosis: A comprehensive review". Open Veterinary Journal 14, n. 6 (2024): 1330. http://dx.doi.org/10.5455/ovj.2024.v14.i6.2.

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The frequent zoonotic disease known as "bovine tuberculosis" is brought on by the Mycobacterium bovis bacteria, which can infect both people and animals. The aim of this review article is to provide an explanation of the etiology, history, epidemiology, pathogenesis, clinical symptoms, diagnosis, transmission, risk factors, public health importance, economic impact, treatment, and control of bovine tuberculosis. Primarily, bovine tuberculosis affects cattle, but other animals may also be affected. Bovine tuberculosis is present throughout the world, with the exception of Antarctica. Cattle that contract bovine tuberculosis might suffer from a persistent, crippling illness. In the early stages of the disease, there are no symptoms. The tuberculin test is the primary method for detecting bovine tuberculosis in cows. Depending on its localized site in the infected animal, M. bovis can be found in respiratory secretions, milk, urine, faeces, vaginal secretions, semen, feces, and exudates from lesions (such as lymph node drainage and some skin lesions). This illness generally lowers cattle productivity and could have a negative financial impact on the livestock business, particularly the dairy industry. The most effective first-line anti-tuberculosis chemotherapy consists of isoniazid, ethambutol, rifampin, and streptomycin. Second line drugs used against bovine tuberculosis include ethionamide, capreomycin, thioacetazone, and cycloserine. To successfully control and eradicate bovine tuberculosis, developed nations have implemented routine testing and culling of infected animals under national mandatory programs.
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5

Sibley, Dick. "Bovine tuberculosis: slow progress". Livestock 28, n. 1 (2 gennaio 2023): 23–25. http://dx.doi.org/10.12968/live.2023.28.1.23.

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Despite a government pledge to eradicate bovine tuberculosis by 2038, progress towards this goal has been slow. This article looks at some of the reasons for this and considers ways in which all parties involved could engage to bring about a more rapid improvement in control of bovine tuberculosis.
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6

Ribeiro, Lucílio Antônio, Vítor Salvador Picão Gonçalves, Priscilla Fernanda Cremer Francisco, Ana Lourdes Arrais de Alencar Mota, Geraldo Teixeira do Nascimento, Janaina Bitencourt Licurgo, Fernando Ferreira et al. "Epidemiological status of bovine tuberculosis in the Federal District of Brazil". Semina: Ciências Agrárias 37, n. 5Supl2 (9 novembre 2016): 3561. http://dx.doi.org/10.5433/1679-0359.2016v37n5supl2p3561.

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Considering the implementation of the National Program for the Control and Eradication of Animal Brucellosis and Tuberculosis (PNCEBT) in 2001, and the need to determine the epidemiological status of animal tuberculosis for future evaluation of the effectiveness of the measures laid down, the objective of this study was to estimate the prevalence and identify risk factors of bovine tuberculosis in the Federal District (DF) of Brazil, as well as to provide an input for the strategic management of PNCEBT. Field testing and data collection was carried out from February to December 2003. The DF was considered a single epidemiological region owing to the small number of existing farms, and the absence of significant differences between the region’s farming enterprises, which would justify the stratification of the regional sample. A total of 278 farms were randomly sampled from the local registry database of bovine farms with reproductive activity, in which 2,019 adult cows were tuberculin tested. Only one sampled animal had a positive result, using the comparative cervical tuberculin test, resulting in a bovine tuberculosis prevalence of 0.05% [95% CI: 0.0-0.4%]. The herd-level prevalence of bovine tuberculosis in the DF was estimated as 0.36% [95% CI: 0-2.0%]. The analysis of risk factors was impaired by the results obtained, as the number of cases did not allow for this kind of analysis. Cattle farming in the DF is predominantly aimed at dairy production; however, it is characterized by the presence of small low milk yield herds, which may not favor the introduction and persistency of infection of Mycobacterium bovis. Health authorities from the DF perform surveillance for bovine tuberculosis and maintain the need for tests for the movement of bovines for breeding and those animals destined for any form of animal gathering, especially auctions. Therefore, it is likely that the DF has good conditions for successfully implementing the PNCEBT.
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7

Cobner, Andrew. "Clinical Forum: Bovine tuberculosis". Livestock 12, n. 5 (settembre 2007): 23–30. http://dx.doi.org/10.1111/j.2044-3870.2007.tb00113.x.

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8

Lehner, R., e F. McKeating. "Bovine tuberculosis in deer". Veterinary Record 124, n. 2 (14 gennaio 1989): 46. http://dx.doi.org/10.1136/vr.124.2.46-c.

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9

Domingo, M., E. Vidal e A. Marco. "Pathology of bovine tuberculosis". Research in Veterinary Science 97 (ottobre 2014): S20—S29. http://dx.doi.org/10.1016/j.rvsc.2014.03.017.

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10

Bezos, Javier, Julio Álvarez, Beatriz Romero, Lucía de Juan e Lucas Domínguez. "Bovine tuberculosis: Historical perspective". Research in Veterinary Science 97 (ottobre 2014): S3—S4. http://dx.doi.org/10.1016/j.rvsc.2014.09.003.

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11

McDonald, Robbie A. "Badgers and bovine tuberculosis". Current Biology 24, n. 4 (febbraio 2014): R141—R143. http://dx.doi.org/10.1016/j.cub.2013.12.014.

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12

Dean, R., D. Gunn-Moore, S. Shaw e A. Harvey. "Bovine tuberculosis in cats". Veterinary Record 158, n. 12 (25 marzo 2006): 419–20. http://dx.doi.org/10.1136/vr.158.12.419.

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13

Monies, B., R. de la Rua e K. Jahans. "Bovine tuberculosis in cats". Veterinary Record 158, n. 14 (8 aprile 2006): 490–91. http://dx.doi.org/10.1136/vr.158.14.490-c.

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14

Monies, B., K. Jahans e R. de la Rua. "Bovine tuberculosis in cats". Veterinary Record 158, n. 7 (18 febbraio 2006): 245–46. http://dx.doi.org/10.1136/vr.158.7.245-a.

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15

Monies, B., K. Jahans e R. de la Rua. "Bovine tuberculosis in cats". Veterinary Record 158, n. 8 (25 febbraio 2006): 280. http://dx.doi.org/10.1136/vr.158.8.280-a.

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16

Chaudhari, Pravin J., Bharat B. Bhanderi e Yash A. Desai. "Prevalence of bovine tuberculosis". International Journal of Advanced Biochemistry Research 8, n. 4 (1 gennaio 2024): 16–24. http://dx.doi.org/10.33545/26174693.2024.v8.i4a.892.

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17

Souza, Ederson Alves de, Paulo Henrique Gilio Gasparotto, Rodrigo Lopes Medeiros, Alini Osowski, Jerônimo Vieira Dantas Filho, José Ivaldo de Siqueira Silva Júnior, Maria das Dores Silva Araújo, Jomel Francisco dos Santos e Luiz Donizete Campeiro Junior. "Condenação de carcaças por tuberculose bovina em um abatedouro frigorífico sob Sistema de Inspeção Federal (SIF) na região central de Rondônia – Brasil". Revista Agraria Academica 5, n. 4 (1 luglio 2022): 88–96. http://dx.doi.org/10.32406/v5n4/2022/88-96/agrariacad.

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Abstract (sommario):
Mycobacterium bovis is the main cause of bovine tuberculosis, being one of the main zoonoses that have a great economic and public health impact. The objective of this research was to evaluate the occurrence of bovine tuberculosis in carcasses through post mortem inspection in a slaughterhouse under the Federal Inspection System (SIF) located in the central region of Rondônia. The total number of slaughtered cattle, carcasses condemned for tuberculosis, the quarterly average and the total average of bovine tuberculosis occurrence were analyzed using descriptive statistics. The occurrence of lesions suggestive of bovine tuberculosis in carcasses in the slaughterhouse studied confirms the importance of inspection and inspection of meat.
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18

Mwelaisha, Kalenga, Rosemary Likwa e Humphrey Simukoko. "Factors Associated with the Prevalence of Bovine Tuberculosis in the Kafue Basin of Zambia". American Journal of Nursing and Health Sciences 5, n. 2 (17 aprile 2024): 46–53. http://dx.doi.org/10.11648/j.ajnhs.20240502.11.

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Worldwide, bovine tuberculosis is most common in agricultural regions of Central and South America, Sub-Saharan Africa and South-Western Asia. Bovine tuberculosis was reported to be endemic in the Zambian traditional cattle sector with a high herd prevalence of 49.8% recorded from areas within, and adjacent to the Kafue Basin as far back as 1995. An analytical cross sectional study design was applied to a sample size of 384 selected cattle owners in the Kafue Basin. A semi-structured questionnaire was administered to the cattle owners who were randomly selected. The data was analyzed using STATA Version 15 Software. The results from the study showed that 54% of the cattle owners experienced bovine tuberculosis among their cattle while 46% did not experience bovine tuberculosis. The prevalence of bovine tuberculosis in cattle was higher among the male cattle owners (76%) compared to female cattle owners (24%). There was a significant relationship of p value &lt; 0.029 between level of knowledge of cattle owners and the prevalence of bovine tuberculosis. Unemployed cattle owners had higher odds of experiencing bovine tuberculosis among their cattle (OR 3.488; 95% CI 1.341-9.067) and the relationship was statistically significant at p value &lt; 0.010. There was equally a significant relationship of p value &lt; 0.042 between vaccination status of animals and the occurrence of bovine tuberculosis. The study showed that the majority of cattle owners lacked awareness and had a lower level of understanding of the disease and its public health significance. Therefore, the implications of the study suggest the creation of disease control programs that will ensure regular herd testing for bovine tuberculosis, routine vaccinations of animals, deliberate quarantine of infected animals as well as community health education about transmission, control and prevention of the disease.
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19

Shaltout, Fahim. "The Slaughter House and the Re-emerging Foodborne Illness with Special Reference to Bovine Tuberculosis". International Journal of Food Engineering and Technology 8, n. 1 (20 febbraio 2024): 8–15. http://dx.doi.org/10.11648/j.ijfet.20240801.12.

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The Slaughter house is the place in which the animals are slaughtered for human consumption. The Slaughter house plays important role in prevention of zoonotic diseases between animals and humans like Mycobacterium tuberculosis as reemerging foodborne illness and also prevent infectious diseases between animals. Bovine Mycobacterium tuberculosis is caused by a species of pathogenic Gram positive, acid fast stain bacteria in the Mycobacteriaceae family. the causative agent bacteria of Bovine tuberculosis as reemerging foodborne illness tuberculosis bacteria has an waxy cover on its surface primarily due to the presence of acid called mycolic which refers the cells impervious to Gram staining, and as a result, the causative agent bacteria of Bovine tuberculosis as reemerging foodborne illness may appear weakly Gram-positive. Acid-fast bacilli by using certain stains called Ziehl Nielsen, or through using stain called fluorescent such as aura mine are used to identify the cause of Bovine tuberculosis as reemerging foodborne illness with a microscope. The Bacteria cause Bovine tuberculosis as a reemerging foodborne illness is aerobic bacteria and needs high concentrations of oxygen. Mainly this bacteria is pathogenic to human and mammal&apos;s respiratory system, it infects the lungs. The most diagnostic means for Bovine tuberculosis as a reemerging foodborne illness are the tuberculin skin examination, stain of acid-fast, laboratory culture, and through using polymerase chain reaction method.
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20

Oluwasile, B. B., O. J. Awoyomi e O. O. Kehinde. "Prevalence and economic loss of bovine tuberculosis in a municipal abattoir, Abeokuta Southwestern Nigeria". Nigerian Journal of Animal Production 40, n. 2 (28 dicembre 2020): 216–23. http://dx.doi.org/10.51791/njap.v40i2.1229.

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A 12 month cross-sectional study was carried out at Lafenwa Abattoir Abeokuta, Southwestern Nigeria from July, 2011 to June, 2012. This was to determine the prevalence and economic loss of bovine tuberculosis in this abattoir. A total of 928 cases of bovine tuberculosis out of 52,273 cattle slaughtered during this period were condemned, representing a total prevalence of 1.78% (95% CI: 1.31- 2.14%). Typical tuberculous lesions were found in the Lung, Liver and Spleen, higher rate of organ condemnation was observed in the lung followed by liver and spleen. There was statistically significant difference in rate of organ condemnation (P<0.05). The monthly prevalence and sequence plot revealed an epidemic tendency for bovine tuberculosis during this period and there was statistically significant difference between prevalence of bovine tuberculosis and seasonal occurrence. An estimated total loss of N1.2 million (US$7,367) due to bovine tuberculosis was observed in this abattoir for the year. It was concluded that bovine tuberculosis is prevalent with epidemic tendency in cattle destined for human consumption, also with attending serious public health implications and huge loss to both the butchers and national economy.
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Ejeh, EF, IF Markus, AS Ejeh, JA Musa, FA Lawan, JA Ameh, AC Kudi e SIB Cadmus. "Seasonal prevalence of Bovine Tuberculous lesions in cattle slaughtered in Yola abattoirs". Bangladesh Journal of Veterinary Medicine 11, n. 2 (11 giugno 2014): 113–20. http://dx.doi.org/10.3329/bjvm.v11i2.19125.

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Bovine tuberculosis is endemic in Nigeria. There is paucity of information on the prevalence of bovine tuberculous lesions in cattle slaughtered in Yola, Adamawa state. The annual prevalence and seasonal variation of bovine tuberculous lesions were assessed based on abattoir records of tuberculosis lesions from 2008 to 2012. The overall prevalence of bovine tuberculosis lesions from 2008 to 2012 ranges from 8.68% (6.03 – 11.33) in 2008 to 10.33% (8.63 – 12.03%) in 2012 with peak prevalence of 12.73% in 2011. Types of lesions were not recorded systematically, however, lesions that were observed ranges from TB granuloma, TB abscesses with yellowish pus, caseous necrotic tubercles, multiple necrosis to focal granulomas. Annual prevalence of bovine tuberculosis lesions recorded in Yola abattoirs differ significantly (p ? 0.05). Prevalence of tuberculous lesions in Yola abattoirs was significantly influenced by season (p < 0.05). Tuberculosis is endemic in cattle slaughtered in abattoirs meant for human consumption in Yola, therefore humans are at risk of acquiring zoonotic tuberculosis through consumption of contaminated meat.DOI: http://dx.doi.org/10.3329/bjvm.v11i2.19125 Bangl. J. Vet. Med. (2013). 11 (2): 113-120
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Healy, E., e S. Rpgers. "Tuberculosis Verrucosa Cutis in Association with Bovine Tuberculosis". Journal of the Royal Society of Medicine 85, n. 11 (novembre 1992): 704–5. http://dx.doi.org/10.1177/014107689208501117.

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Borham, Mohamed, Atef Oreiby, Attia El-Gedawy, Yamen Hegazy, Hazim O. Khalifa, Magdy Al-Gaabary e Tetsuya Matsumoto. "Review on Bovine Tuberculosis: An Emerging Disease Associated with Multidrug-Resistant Mycobacterium Species". Pathogens 11, n. 7 (21 giugno 2022): 715. http://dx.doi.org/10.3390/pathogens11070715.

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Abstract (sommario):
Bovine tuberculosis is a serious infectious disease affecting a wide range of domesticated and wild animals, representing a worldwide economic and public health burden. The disease is caused by Mycobacteriumbovis and infrequently by other pathogenic mycobacteria. The problem of bovine tuberculosis is complicated when the infection is associated with multidrug and extensively drug resistant M. bovis. Many techniques are used for early diagnosis of bovine tuberculosis, either being antemortem or postmortem, each with its diagnostic merits as well as limitations. Antemortem techniques depend either on cellular or on humoral immune responses, while postmortem diagnosis depends on adequate visual inspection, palpation, and subsequent diagnostic procedures such as bacterial isolation, characteristic histopathology, and PCR to reach the final diagnosis. Recently, sequencing and bioinformatics tools have gained increasing importance for the diagnosis of bovine tuberculosis, including, but not limited to typing, detection of mutations, phylogenetic analysis, molecular epidemiology, and interactions occurring within the causative mycobacteria. Consequently, the current review includes consideration of bovine tuberculosis as a disease, conventional and recent diagnostic methods, and the emergence of MDR-Mycobacterium species.
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Krajewska-Wędzina, Monika, Monika Kozińska, Blanka Orłowska, Marcin Weiner, Krzysztof Szulowski, Ewa Augustynowicz-Kopeć, Krzysztof Anusz e Noel H. Smith. "Molecular characterisation of Mycobacterium caprae strains isolated in Poland". Veterinary Record 182, n. 10 (6 dicembre 2017): 292. http://dx.doi.org/10.1136/vr.104363.

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Bovine tuberculosis (bovine TB, bTB) is caused by bovine bacilli: Mycobacterium bovis and M caprae. The studies conducted in Poland, in the National Bovine Tuberculosis Reference Laboratory in the Department of Microbiology of the National Veterinary Research Institute in Pulawy, show that animal tuberculosis in Poland is also caused by M caprae. We here describe the identification and genotypic assessment of 52 isolates of M caprae obtained from Polish cattle and wild animals over the last five years. We show that strains isolated from bison have significant genotypic diversity and are distinct compared with the genotypes of strains isolated from cattle. Similarly, isolates from cattle herds can be highly genotypically variable. Formal designation of the members of the Mycobacterium tuberculosis complex is controversial in Poland; there is a gap in veterinary legislation with regard to bTB and no explicit mention of M caprae causing tuberculosis in animal.
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Ortiz Muñoz, Edgardo Patricio. "La Tuberculosis Bovina: un problema aún sin resolver. / Bovine Tuberculosis: a yet unresolved issue". CIBA Revista Iberoamericana de las Ciencias Biológicas y Agropecuarias 4, n. 8 (12 gennaio 2016): 162. http://dx.doi.org/10.23913/ciba.v4i8.32.

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El Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias (INIFAP), es una institución cuya misión es “contribuir al desarrollo productivo, competitivo, equitativo y sustentable de las cadenas agropecuarias y forestales, mediante la generación y adaptación de conocimientos científicos e innovaciones tecnológicas y la formación de recursos humanos para atender las demandas y necesidades en beneficio del sector y la sociedad en un marco de cooperación institucional con organizaciones públicas y privadas”. Por otra parte, se define como una institución que “brinda excelencia científica y tecnológica con liderazgo y reconocimiento nacional e internacional por su capacidad de respuesta a las demandas de conocimiento e innovaciones tecnológicas en beneficio agrícola, pecuario y de la sociedad en general”
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Lazzaretti, Renan, Ezequiel Davi dos Santos, Diorges Henrique Setim, Tanise Policarpo Machado, Renata Seibel, Carlos Bondan, Ricardo Zanella, Giseli Aparecida Ritterbusch e Adriana Costa da Motta. "Anatomopathological and immunohistochemical characterization of a case of granulomatous meningoencephalitis in a bovine with systemic tuberculosis / Caracterização anatomopatológica e imuno-histoquímica de um caso de meningite granulomatosa em bovino com tuberculose sistêmica". Brazilian Journal of Development 8, n. 5 (31 maggio 2022): 42395–403. http://dx.doi.org/10.34117/bjdv8n5-624.

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A two-year-old male bovine of Aberdeen Angus breed with anorexia, weight loss, and apathy was reported for necropsy, being diagnosed with systemic tuberculosis and tuberculoid meningitis lesions. Bovine tuberculosis was observed and confirmed through the necropsy of granulomatous lesions, mainly in the lungs and regional lymph nodes; specific staining for alcohol-acid resistant bacilli and immunohistochemistry were also performed. It should be noted that bovine tuberculosis is a zoonotic disease, with mandatory notification, caused by Mycobacterium bovis. In most cases, it has nonspecific clinical symptoms, such as respiratory signs, weight loss, and lymphadenopathy. In rare cases, alterations in the central nervous system occur. Therefore, this study aimed to report a case of granulomatous meningitis in a bovine with systemic tuberculosis through the characterization of its anatomicopathological and immunohistochemical aspects.
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Baratov, M. O. "Improvement of bovine tuberculosis diagnosis". Veterinary Science Today, n. 4 (13 gennaio 2021): 261–65. http://dx.doi.org/10.29326/2304-196x-2020-4-35-261-265.

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Abstract (sommario):
Detection of animals with non-specific reactions to tuberculin is one of the major problems in bovine tuberculosis (TB) diagnosis. There is a need to find and improve methods for detection of the sensitization causes. This paper presents the results of comparative studies of different ways to stabilize red blood cells in order to obtain diagnosticums for indirect hemagglutination (IHA) test. The article describes the stages of red blood cells stabilization and sensitization and demonstrates the diagnostic significance of Fili stabilization method using formaldehyde as a fixative. The highest antibody titers (1:3000 and 1:4000) were received in hyperimmune sera of rabbits immunized with Mycobacterium bovis using a homologous diagnosticum. Practical importance of the sensitins homologous to the infection is shown during testing of 1,911 serum samples collected from animals of different categories (diseased; healthy and reacting to tuberculin; healthy and not reacting to tuberculin) with IHA test using diagnosticums produced from Mycobacterium bovis and Mycobacterium fortuitum. Based on the positive results of the IHA test, TB was diagnosed in 87.5% of animals originating from an infected farm during post-mortem examination. The results of the IHA test agreed with those of the intradermal tuberculin test in 37.7% of cases. Diagnostic antibody titers were found in 206 TB infected animals with no reaction to the intradermal test. However, the post-mortem examination revealed TB changes in internal organs. The obtained data suggest a possibility to use the IHA test to detect TB infected animals with non-specific reactions to tuberculin.
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Hamdan Alameri, Omran. "Bovine Tuberculosis in young heifer". Current Research in Microbiology and Infection 1, n. 1 (novembre 2020): 1–4. http://dx.doi.org/10.31559/crmi2020.1.1.1.

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Abstract (sommario):
A rare case of bovine tuberculosis in young heifer is reported. Miss diagnosed in several occasions due to lack of diagnostic tools. However; post-mortem lesion diagnosis is paramount. This case may pose public health concern to the farmer and his family.
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29

Mugambi, JM, SG Omwenga, HO Wesonga, P. Mbatha, S. Gathogo, AC Chota, HB Magwisha, ZE Makondo, E. Rukambile e R. Mwakapuja. "Bovine Tuberculosis in East Africa". African Crop Science Journal 24, n. 1 (1 aprile 2016): 53. http://dx.doi.org/10.4314/acsj.v24i1.6s.

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30

Tschopp, R., S. Berg, K. Argaw, E. Gadisa, M. Habtamu, E. Schelling, D. Young, A. Aseffa e J. Zinsstag. "BOVINE TUBERCULOSIS IN ETHIOPIAN WILDLIFE". Journal of Wildlife Diseases 46, n. 3 (luglio 2010): 753–62. http://dx.doi.org/10.7589/0090-3558-46.3.753.

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31

GEE, R. W. "Bovine tuberculosis eradication in Australia". Revue Scientifique et Technique de l'OIE 5, n. 3 (1 settembre 1986): 789–94. http://dx.doi.org/10.20506/rst.5.3.260.

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32

Monies, R. J., B. Rule, M. P. Cranwell, N. Palmer, J. Inwald e R. G. Hewinson. "Bovine tuberculosis in domestic cats". Veterinary Record 146, n. 14 (1 aprile 2000): 407–8. http://dx.doi.org/10.1136/vr.146.14.407.

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33

Akpabio, Uduak. "A Review on Bovine Tuberculosis". Journal of Veterinary Advances 5, n. 3 (2015): 841. http://dx.doi.org/10.5455/jva.20150315015831.

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34

Bentil, D. E., e J. D. Murray. "Modelling Bovine Tuberculosis in Badgers". Journal of Animal Ecology 62, n. 2 (aprile 1993): 239. http://dx.doi.org/10.2307/5355.

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35

Pollock, J. M., J. McNair, M. D. Welsh, R. M. Girvin, H. E. Kennedy, D. P. Mackie e S. D. Neill. "Immune responses in bovine tuberculosis". Tuberculosis 81, n. 1-2 (febbraio 2001): 103–7. http://dx.doi.org/10.1054/tube.2000.0258.

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36

Gunning, R. "Bovine tuberculosis in roe deer". Veterinary Record 116, n. 11 (16 marzo 1985): 300–301. http://dx.doi.org/10.1136/vr.116.11.300-b.

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37

PAYEUR, JANET B., S. CHURCH, L. MOSHER, B. ROBINSON-DUNN, S. SCHMITT e D. WHIPPLE. "Bovine Tuberculosis in Michigan Wildlife". Annals of the New York Academy of Sciences 969, n. 1 (ottobre 2002): 259–61. http://dx.doi.org/10.1111/j.1749-6632.2002.tb04389.x.

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38

Cousins, Debby. "Eliminating bovine tuberculosis from Australia". Microbiology Australia 33, n. 4 (2012): 165. http://dx.doi.org/10.1071/ma12165.

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Abstract (sommario):
Mycobacterium bovis, the causative organism of bovine tuberculosis (TB), has a worldwide distribution. Australia, like most developed countries, recognised the zoonotic risk of bovine TB, and embarked on state control programs to minimise the incidence of disease in cattle in the 1960’s and a national campaign to eradicate the disease in 1970. Veterinarians, physicians and many other different disciplines worked cooperatively in Australia to understand and solve the problem; perhaps a very early example of the One Health concept in action.
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39

McDonald, Robbie A. "How to control bovine tuberculosis". Nature 511, n. 7508 (luglio 2014): 158–59. http://dx.doi.org/10.1038/nature13514.

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40

Sharp, David. "Bovine tuberculosis and badger blame". Lancet 367, n. 9511 (febbraio 2006): 631–33. http://dx.doi.org/10.1016/s0140-6736(06)68240-8.

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41

Wilkins, E. G. L., R. J. Griffiths e C. Roberts. "Bovine tuberculosis of the skin". Journal of Infection 12, n. 3 (maggio 1986): 280–81. http://dx.doi.org/10.1016/s0163-4453(86)94502-0.

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42

Doherty, M. L., e J. P. Cassidy. "New Perspectives on Bovine Tuberculosis". Veterinary Journal 163, n. 2 (marzo 2002): 109–10. http://dx.doi.org/10.1053/tvjl.2002.0654.

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43

Simpson, V. "Bovine tuberculosis in Eurasian otters". Veterinary Record 164, n. 25 (20 giugno 2009): 789. http://dx.doi.org/10.1136/vr.164.25.789-a.

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44

Hancox, M. "The infectiveness of bovine tuberculosis". Animal Welfare 4, n. 2 (maggio 1995): 159. http://dx.doi.org/10.1017/s0962728600017747.

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Abstract (sommario):
Sir, I must make a brief response to Tumbull's suggestion (1995 Animal Welfare 3: 340) that I am misinformed in my belief that cattle are infectious immediately after exposure to the tuberculosis organism. There seem to be two schools of thought on this issue, and yet it is one of critical importance in tackling the final stages of tuberculosis eradication schemes. On the one hand it is claimed that only cattle with gross visible lesions at abattoir inspection are capable of passing on tuberculosis (TB) to other cattle (Gallagher 1980; Dunnet et al 1986; Tumbull 1994; Wilesmith & Williams 1986). On the other hand this view is not substantiated by other studies on the aetiology and pathogenesis of cattle TB. For most adult cattle, tuberculosis seems to start as a lung infection following inhalation of infected aerosolised sputum or dust. Primary lesions may heal, but more usually they remain open, and may persist as the subclinically latent condition, or progress slowly or rapidly to chronic, or fatal and acute bronchopneumonia. And even where an apparent sealed tubercle develops, it would seem that intracanalicular bronchiolar spread continues, such that intermittent or continuous bacterial shedding occurs in the sputum. Therefore cattle with micro-lesions that would be missed at gross abattoir inspection could be infectious to other cattle despite being non-visibly-lesioned in the lungs or visibly-lesioned only in bronchomediastinal lymph nodes. Such cattle may also be producing infectious faeces via swallowed sputum (Blood et al 1979; Francis 1947; Jubb & Kennedy 1970; Neill et al 1994; Richards 1972).
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45

Chaudhari, Pravin J., Bharat B. Bhanderi, Yash A. Desai e Bhoomi B. Chaudhari. "Bovine tuberculosis diagnosis: An overview". International Journal of Advanced Biochemistry Research 8, n. 4 (1 gennaio 2024): 16–20. http://dx.doi.org/10.33545/26174693.2024.v8.i4a.890.

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46

Minharro, Silvia, Cristiane De Morais Alves, Pedro Moacyr Pinto Coelho Mota, Elaine Maria Seles Dorneles, Andréa Padilha de Alencar, Raimundo Magalhães dos Santos, Bruno Meireles Leite e Andrey Pereira Lage. "Tuberculosis in water buffalo (Bubalus bubalis) in the Baixo Araguari Region, Amapá, Brazil". Semina: Ciências Agrárias 37, n. 2 (26 aprile 2016): 885. http://dx.doi.org/10.5433/1679-0359.2016v37n2p885.

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Abstract (sommario):
Water buffalo are of great economic importance in Brazilian Amazonia, which has the largest herd in Brazil. Bovine tuberculosis caused by Mycobacterium bovis is a zoonotic disease that results in severe losses to water buffalo production. Although the disease has already been described in the country, data on the occurrence and distribution of bovine tuberculosis in water buffalo in Brazil is very scarce. The aim of this study was to determine the frequency of bovine tuberculosis in water buffalo in the Baixo Araguari River region of Amapá, Brazil. Thirty herds, randomly selected from the 41 herds of water buffalo in the region, were sampled. From those herds, 212 randomly selected water buffalo were subjected to the comparative tuberculin skin test. The proportion of Baixo Araguari River region herds that were positive for bovine tuberculosis was 50.0% (95% CI 31.3% to 68.7%) and the proportion of animals that were positive was estimated to be 14.8% (95% CI 7.8% to 21.9%). Our results show that bovine tuberculosis is spread widely among water buffalo in the Baixo Araguari River region, which suggests that measures to control the disease should be undertaken in the region.
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47

Galvis, Jason Onell Ardila, José Henrique Hildebrand Grisi-Filho, Daniele Da Costa, Alba Luisa Pereira Ribeiro Said, Marcos Amaku, Ricardo Augusto Dias, Fernando Ferreira et al. "Epidemiologic characterization of bovine tuberculosis in the State of Espírito Santo, Brazil". Semina: Ciências Agrárias 37, n. 5Supl2 (9 novembre 2016): 3567. http://dx.doi.org/10.5433/1679-0359.2016v37n5supl2p3567.

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Abstract (sommario):
A cross-sectional study was carried out between January 2012 and May 2014 to investigate the status of bovine tuberculosis in the state of Espírito Santo. The state was divided into two regions, and in each of them, 300 farms with reproductive activity were randomly selected and considered as the primary sampling units. In the selected farms, a fixed number of female bovines aged over 2 years were randomly selected to undergo a comparative cervical tuberculin test; an epidemiologic questionnaire was also applied. In the state of Espírito Santo, the apparent prevalence of tuberculosis-positive farms was 7.6% (95% confidence interval [CI] = 5.7-9.9). Prevalence at the herd level varied from 4.6% (95% CI = 2.6-7.3) in region 1 to 11.1% (95% CI = 7.7-15.3) in region 2. The apparent prevalence of tuberculosis-positive animals was 0.7% (95% CI = 0.3-1.1) in the state, and the prevalence varied from 0.3% (95% CI = 0.2-0.6) in region 1 to 1.2% (95% CI = 0.3-2.9) in region 2. The risk factors associated with tuberculosis prevalence in Espírito Santo were the number of adult females ? 10 (odds ratio [OR] = 2.40; 95% CI = 1.17-5.31) and milking type (milking machine/milking parlor) (OR = 2.88; 95% CI = 1.36-5.86]). The state of Espírito Santo should set up a surveillance system to detect and control bovine tuberculosis, taking into account the importance of dairy farms and animal trade in the state.
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48

Alberti, Taina S., Fabio Raphael P. Bruhn, Rosimeri Zamboni, Fabiano R. Venancio, Haide Valeska Scheid, Margarida B. Raffi, Ana Lucia Schild e Eliza Simone V. Sallis. "Epidemiological analysis of bovine tuberculosis in the southern region of Rio Grande do Sul from 2000 to 2015". Pesquisa Veterinária Brasileira 40, n. 2 (febbraio 2020): 77–81. http://dx.doi.org/10.1590/1678-5150-pvb-6406.

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Abstract (sommario):
ABSTRACT: Bovine tuberculosis (BTB) is an infectious and zoonotic disease with socioeconomic importance, responsible for economic losses in livestock due to the decrease in animal productivity, mortality, bovine carcass condemnation and restriction on exportations. The objective of the present study was to evaluate the epidemiological aspects of this disease through a descriptive analysis and time series of cases of bovine tuberculosis diagnosed at the Laboratório Regional de Diagnóstico (LRD) of the Faculdade de Medicina Veterinária, Universidade Federal de Pelotas (UFPel) from 2000 to 2015. A survey was carried out in the LRD database of cases diagnosed as tuberculosis in cattle during this period. The incidence rate of BTB ([cases/population] x 100000) was calculated. Qualitative variables (sex, age, race, origin, type of material and presumptive diagnosis) were analyzed in a descriptive way, aiming to establish the profile of affected animals, characterize the municipalities in which the disease is originated and also fix the main referral organs for diagnosis. The time series analysis was performed using the Gretl statistical software 1.9.12 (GNU Regression, Econometric and Time-series Library). To verify the existence of the stationary distribution, the test of Dickey-Fuller was used, considering a value of p<0.05. During this period, 331 cases of BTB were diagnosed in the LRD. The present study identified that the predominant profile of the bovines affected by tuberculosis was female bovine aged more than two years old and crossbreed; the main organ sent for histopathological examination was lymph nodes. The microregion of Pelotas presented the highest incidence of the disease. There was also a tendency of a decrease in the incidence rate of this disease over the years, absence of seasonal influence in the occurrence of the disease and no cases of epidemics occurred from 2002 to 2015 in the area covered by the LRD-UFPel.
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49

Good, Margaret, e Anthony Duignan. "Perspectives on the History of Bovine TB and the Role of Tuberculin in Bovine TB Eradication". Veterinary Medicine International 2011 (2011): 1–11. http://dx.doi.org/10.4061/2011/410470.

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Abstract (sommario):
Tuberculosis remains a significant disease of animals and humans worldwide. Bovine tuberculosis is caused by Mycobacteria with an extremely wide host range and serious, although currently probably underdiagnosed, zoonotic potential. Where bovine tuberculosis controls are effective, human zoonotic TB, due toMycobacterium bovisorM. caprae, is uncommon and clinical cases are infrequent in cattle. Therefore, the control and ultimate eradication of bovine tuberculosis is desirable. Tuberculin tests are the primary screening tool used in bovine eradication. The choice of tuberculin test is dependent on the environment in which it is to be used. Tuberculin potency is critical to test performance, and the accurate determination of potency is therefore particularly important. The design of a control or eradication programme should take into consideration the fundamental scientific knowledge, the epidemiological profile of disease, the experience of other eradication programmes, and the presence, in the same ecosystem, of maintenance hosts, in which infection is self-sustaining and which are capable of transmitting infection. A control or eradication programme will necessarily require modification as it progresses and must be under constant review to identify the optimal desirable goals, the efficacy of policy, and constraints to progress.
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50

Bonilla-Aldana, D. Katterine, S. Daniela Jiménez-Diaz, Carlos Lozada-Riascos, Kenneth Silva-Cajaleon e Alfonso J. Rodríguez-Morales. "Mapping Bovine Tuberculosis in Colombia, 2001–2019". Veterinary Sciences 11, n. 5 (15 maggio 2024): 220. http://dx.doi.org/10.3390/vetsci11050220.

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Abstract (sommario):
Introduction: Bovine tuberculosis is a zoonotic disease of significant impact, particularly in countries where a pastoral economy is predominant. Despite its importance, few studies have analysed the disease’s behaviour in Colombia, and none have developed maps using geographic information systems (GIS) to characterise it; as such, we developed this study to describe the temporal–spatial distribution of bovine tuberculosis in Colombia over a period of 19 years. Methods: A retrospective cross-sectional descriptive study, based on reports by the Colombian Agricultural Institute (ICA), surveillance of tuberculosis on cattle farms in Colombia from 2001 to 2019 was carried out. The data were converted into databases using Microsoft Access 365®, and multiple epidemiological maps were generated with the QGIS® version 3.36 software coupled to shape files of all the country’s departments. Results: During the study period, 5273 bovine tuberculosis cases were identified in multiple different departments of Colombia (with a mean of 278 cases/year). Regarding its temporal distribution, the number of cases varied from a maximum of 903 cases (17.12% of the total) in 2015 to a minimum of 0 between 2001 and 2004 and between 2017 and 2019 (between 2005 and 2016, the minimum was 46 cases, 0.87%). Conclusions: GIS are essential for understanding the temporospatial behaviour of zoonotic diseases in Colombia, as is the case for bovine tuberculosis, with its potential implications for the Human and One Health approaches.
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