Tesi sul tema "Boron-neutron capture therapy"
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Howard, William Bruce. "Accelerator-based boron neutron capture therapy". Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/44479.
Testo completoHefne, Jameel. "Neutron spectrum measurement for Boron Neutron Capture Therapy". Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/16625.
Testo completoGoorley, John Timothy 1974. "Boron neutron capture therapy treatment planning improvements". Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/49670.
Testo completoIncludes bibliographical references.
The Boron Neutron Capture Therapy (BNCT) treatment planning process of the Harvard/MIT team used for their clinical Phase I trials is very time consuming. If BNCT proves to be a successful treatment, this process must be made more efficient. Since the Monte Carlo treatment planning calculations were the most time consuming aspect of the treatment planning process, requiring more than thirty six hours for scoping calculations of three to five beams and final calculations for two beams, it was targeted for improvement. Three approaches were used to reduce the calculation times. A statistical uncertainty analysis was performed on doses rates and showed that a fewer number of particles could not be used and still meet uncertainty requirements in the region of interest. Unused features were removed and assumptions specific to the Harvard/MIT BNCT treatment planning calculations were hard wired into MCNP by Los Alamos personnel, resulting in a thirty percent decrease in runtimes. MCNP was also installed in parallel on the treatment planning computers, allowing a factor of improvement by roughly the number of computers linked together in parallel. After theses enhancements were made, the final executable, MCNPBNCT, was tested by comparing its calculated dose rates against the previously used executable, MCNPNEHD. Since the dose rates in close agreement, MCNPBNCT was adopted. The final runtime improvement to a single beam scoping run by linking the two 200MHz Pentium Pro computers was to reduce the wall clock runtime from 2 hours thirty minutes to fifty nine minutes. It is anticipated that the addition of ten 900 MHz CPUs will further reduce this calculation to three minutes, giving the medical physicist or radiation oncologist the freedom to use an iterative approach to try different radiation beam orientations to optimize treatment. Additional aspects of the treatment planning process were improved. The previously unrecognized phenomenon of peak dose movement during irradiation and its potential for overdosing the subject was identified. A method of predicting its occurrence was developed to prevent this from occurring. The calculated dose rate was also used to create dose volume histograms and volume averaged doses. These data suggest an alternative method for categorizing the subjects, rather than by peak tissue dose.
by John Timothy Goorley.
S.M.
Matalka, Khalid Zuhair. "Boron neutron capture therapy of brain tumors /". The Ohio State University, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=osu148778039326795.
Testo completoGuidi, Claretta. "Sviluppo e applicazioni della boron neutron capture therapy". Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017. http://amslaurea.unibo.it/13399/.
Testo completoShah, Jungal (Jugal Kaushik). "Hypoxia-selective compounds for boron neutron capture therapy". Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/44829.
Testo completo"June 2008."
Includes bibliographical references.
Boron neutron capture therapy (BNCT) is a biochemically targeted form of radiotherapy for cancer. In BNCT, a compound labeled with the stable isotope boron-10 is systemically administered, and tumor cells selectively uptake the boron-10 containing compound at higher concentrations than normal cells. A general problem with the tumor seeking compounds is that drug delivery is dependent upon sufficient vascularization within the tumor. To investigate the possibility of delivering boron to hypoxic regions of tumor, a new boronated nitroimidazole delivery agent has been synthesized as a carrier of boron-10 for BNCT. It is expected that this will be used in combination with the existing boron carrier boronophenylalanine-fructose to treat solid tumors. An immunohistochemical protocol to visualize hypoxia was tested and refined to confirm the suitability of two tumor models established in the lab for hypoxia related uptake studies. The immunohistochemical protocol is used to detect pimonidazole, which localizes at hypoxic regions in tissue and is the parent compound for the new hypoxia-selective boron carrier. The protocol was used to test and confirm the suitability of a hypoxic in vivo tumor model. Two tumor lines were tested: SCCVII squamous cell carcinoma and EMT-6 murine mammary carcinoma. Both exhibited hypoxia. Finally, quantitative studies using Inductive Coupled Plasma Atomic Emission Spectrum demonstrated that the synthesized boronated nitroimidazole reaches suitable concentrations in SCCVII and F98 tumor. Future therapeutic studies are required to empirically confirm the effectiveness of this compound.
by Jugal Shah.
S.B.
Wang, Zhonglu. "Design of a Boron Neutron Capture Enhanced Fast Neutron Therapy Assembly". Diss., Georgia Institute of Technology, 2006. http://hdl.handle.net/1853/14100.
Testo completoSweezy, Jeremy Ed. "Development of a boron neutron capture enhanced fast neutron therapy beam". Diss., Georgia Institute of Technology, 2002. http://hdl.handle.net/1853/17107.
Testo completoKudchadker, Rajat. "Optimized accelerator based epithermal neutron beams for boron neutron capture therapy /". free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9821332.
Testo completoChung, Yoonsun. "Radiobiological evaluation of new boron delivery agents for boron neutron capture therapy". Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/44784.
Testo completoIncludes bibliographical references (p. 123-132).
This thesis evaluates the radiobiological effectiveness of three new boron compounds namely a boronated porphyrin (BOPP) and two liposome formulations for neutron capture therapy (BNCT). The methodology utilizes in vitro and in vivo comparisons that characterize compounds relative to boric acid and boronophenylalanine (BPA). In vitro evaluations utilized a colorimetric assay and 96-well plates to minimize the quantities of compound required for testing. The assay was optimized for the murine SCCVII, squamous cell carcinoma to determine the chemical toxicity and relative cellular uptake of a compound. BOPP was toxic at low concentrations and comparisons between the different compounds for thermal neutron irradiations were performed with approximately 5 [mu]g 10B/ml in the culture medium to allow radiation induced effects to govern the observed response. Using less than 300 [mu]g of compound and 250 kVp X-rays as control irradiations, a compound biological effectiveness (CBE) of 3.3 ± 0.7 was determined for BOPP that is comparable to the result for boric acid (3.5 ± 0.5) indicating a non-selective intracellular accumulation of 10B. BPA has a significantly higher CBE of 6.1 + 0.7. Boronated liposomes (MAC-16 and MAC+TAC) were evaluated with the EMT-6 murine mammary carcinoma. Biodistribution studies showed high 10B uptake in tumor (20-40 [mu]g 10B/g) 30 hours after a single i.v. injection (dose 6-20 [mu]g 10B per gram of body weight). Tumor control experiments were performed using thermal neutrons to study the efficacy of the boron delivered by liposomes and BPA. The MAC-16 produced a 16 % tumor control and BPA (dose 43 [mu]g 10B/gbw) 63 % for tumor boron concentrations of approximately 20 [mu]g 10B/g and the same neutron fluence.
(cont.) Liposome doses were limited by injection volume and so two injections were tried 2-hours apart that doubled the boron concentration in tumor compared to a single administration. This improved the therapeutic response to 67 % with less apparent skin damage than with BPA. Microscopic studies using fluorescent labeled liposomes revealed 10B was nonuniformly distributed and concentrated at the edge of the tumor. Based on these studies in the tumor cell lines chosen neither of the compounds appear superior to BPA.
by Yoonsun Chung.
Ph.D.
GASPAR, PRISCILA de F. "Consideracoes sobre o estudo da BNCT (Terapia de captura neutronica por boro)". reponame:Repositório Institucional do IPEN, 1994. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10384.
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Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP
Bosko, Andrey. "General Electric PETtrace cyclotron as a neutron source for boron neutron capture therapy". Diss., Texas A&M University, 2005. http://hdl.handle.net/1969.1/2606.
Testo completoGhani, Zamir. "The physics, dosimetry and microdosimetry of boron neutron capture therapy". Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4000/.
Testo completoPhoenix, Ben. "Synergistic and dose rate effects in Boron Neutron Capture Therapy". Thesis, University of Birmingham, 2013. http://etheses.bham.ac.uk//id/eprint/4084/.
Testo completoKiger, Jingli Liu. "Radiobiology of normal rat lung in Boron Neutron Capture Therapy". Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/41286.
Testo completoIncludes bibliographical references.
Boron Neutron Capture Therapy (BNCT) is a binary cancer radiation therapy that utilizes biochemical tumor cell targeting and provides a mixed field of high and low Linear Energy Transfer (LET) radiation with differing biological effectiveness. This project investigated the radiobiology of normal rat lung in BNCT and measured the relative biological effectiveness factors for the lung. Rat thorax irradiations were carried out with x-rays and neutrons with or without the boron compound boronophenylalanine-fructose (BPA-F). Monte Carlo radiation transport simulations were used to design the rat lung neutron irradiations. Among the neutron beam facilities available for BNCT at the MIT Research Reactor, the thermal neutron beam facility was found to provide a suitable dose distribution for this project. A delimiter was designed and constructed for the rat lung irradiations as a lithiated-polyethylene plate of 1.5 cm thickness with an aperture tapered from 4 to 3 cm in width to expose the lung to the beam and shield adjacent radiosensitive organs. The simulation design was validated with in-phantom measurements using gold foil activation and the dual ion chamber technique. By using a two-field irradiation, a relatively uniform dose distribution could be delivered to the rat lung. The mean lung dose rate was 18.7 cGy/min for neutron beam only irradiation and 37.5 cGy/min with neutrons plus BPA and a blood boron concentration of 18 gg/g.
(cont.) The delimiter designed for rat lung irradiation, and another similar delimiter, along with the animal holding box, all designed in this project, also serve as the apparatus for other small animal irradiations and cell irradiations at the thermal neutron facility at the MIT Research Reactor. An open-flow whole-body plethysmography system with fully automated signal processing programs was developed to non-invasively measure rat breathing rates and lung functional damage after lung irradiation. Noise reduction was carried out against high frequencies beyond the range of rat breathing frequency and large amplitude spikes due to abnormal animal movement. The denoised breathing signals were analyzed using the Fast Fourier Transform with a circular moving block in combination with the bootstrap for noise suppression and to allow estimation of the statistical uncertainty (standard deviation) of frequency measurements. The major frequency of the mean frequency spectrum was determined as the breathing frequency. The mean control breathing rate was 176 ± 13 (7.4%) min' (mean ± SD), and breathing rates 20% (- 3 SD) above the control average were considered to be abnormally elevated. The mean standard deviation of all measurements (n = 4269) was 2.4%. The dose responses of different irradiation groups with breathing rate elevation as the biological endpoint were evaluated with probit analysis. Two response phases of breathing rate elevation were observed as the early response phase (<100 days) and the late response phase (>100 days). The ED50 values for x-rays, neutrons only, and neutrons plus BPA during the early response phase, and neutrons plus BPA during the late response phase, were 11.5 ± 0.4 Gy, 9.2 + 0.5 Gy, 8.7 ± 0.6 Gy and 6.7 ± 0.4 Gy, respectively.
(cont.) The radiobiological weighting factors for the neutron beam (neutrons and photons), thermal neutrons only, %°B dose component during the early response phase, and 10B dose component during the late response phase were 1.24 ± 0.08, 2.2 ± 0.4, 1.4 ± 0.2, and 2.3 + 0.3, respectively. The histological damage to the lung during the late phase was also quantified with a histological scoring system. A set of linear dose response curves with histological damage as the endpoint was constructed. The radiobiological weighting factors for the different dose components were also determined at a degree of lung histological damage corresponding to a median histological score between the baseline (similar to the control) and the maximum. The weighting factors measured, 1.22 ± 0.09 for the thermal neutron beam and 1.9 + 0.2 for the o1B dose component, are consistent with the corresponding weighting factors measured using functional damage. The knowledge gained in these radiobiological studies of the normal rat lung indicates that the lung complications experienced by two patients in the Harvard-MIT clinical trial of BNCT for brain tumors do not appear to be related to the BNCT irradiations. This project is also helpful for evaluating the feasibility of BNCT for lung cancer.
by Jingli Liu Kiger.
Ph.D.
Pitto-Barry, Anaïs. "Polymers and boron neutron capture therapy(BNCT): a potent combination". Royal Society of Chemistry, 2021. http://hdl.handle.net/10454/18415.
Testo completoBoron neutron capture therapy (BNCT) has a long history of unfulfilled promises for the treatment of aggressive cancers. In the last two decades, chemists, physicists, and clinical scientists have been coordinating their efforts to overcome practical and scientific challenges needed to unlock its full therapeutic potential. From a chemistry point of view, the two current small-molecule drugs used in the clinic were developed in the 1950s, however, they both lack some of the essential requirements for making BNCT a successful therapeutic modality. Novel strategies are currently used to design new drugs, more selective towards cancer cells and tumours, as well as able to deliver high boron contents to the target. In this context, macromolecules, including polymers, are promising tools to make BNCT an effective, accepted, and front-line therapy against cancer. In this review, we will provide a brief overview of BNCT, and its potential and challenges, and we will discuss the most promising strategies that have been developed so far.
Ceberg, Crister. "Pharmacokinetics and biodistribution of boron compounds foundations for boron neutron capture theory /". Lund : Dept. of Radiation Physics, Lund University, 1994. http://books.google.com/books?id=wnhrAAAAMAAJ.
Testo completoMitchell, Hannah Elizabeth. "An accelerator-based epithermal photoneutron source for boron neutron capture therapy". Diss., Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/16345.
Testo completoFrixa, Christophe. "Boronated tetraphenylporphyrins for use in boron neutron capture therapy of cancer". Thesis, University of Bath, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268747.
Testo completoKortesniemi, Mika. "Solutions for clinical implementation of boron neutron capture therapy in Finland". Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/fysik/vk/kortesniemi/.
Testo completoDobelbower, Michael Christian. "An integrated design of an accelerator-based neutron source for boron neutron capture therapy /". The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu148794815862645.
Testo completoBrown, Adam Vernon. "Development of a high-power neutron producing [lithium] target for boron neutron capture therapy". Thesis, University of Birmingham, 2000. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.761253.
Testo completoBasak, Prakitri. "Synthesis of conjugates of L-fucose and ortho-carborane as potential agents for boron neutron capture therapy and synthesis of 2,3-dideoxy-2,3-methanoribofuranoside glycosyl donors and a study of their use in stereocontrolled glycosylation reactions". Columbus, OH : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1041010809.
Testo completoTitle from first page of PDF file. Document formatted into pages; contains xiii, 279 p.: ill. (some col.). Includes abstract and vita. Advisor: Todd L. Lowary, Dept. of Chemistry. Includes bibliographical references (p. 150-154).
Ishikawa, Masayori. "Development of New Absorbed Dose Estimation System for Boron Neutron Capture Therapy". Kyoto University, 2002. http://hdl.handle.net/2433/149649.
Testo completoLedesma, Michelle N. (Michelle Nicole) 1975. "Medical room design for a fission converter-based boron neutron capture therapy facility". Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/50533.
Testo completoQu, Tanxia. "A Monte Carlo design study of an accelerator epithermal neutron irradiation facility for boron neutron capture therapy /". The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487844105974799.
Testo completoSchmitz, Tobias [Verfasser]. "ESR-dosimetry in thermal and epithermal neutron fields for application in Boron Neutron Capture Therapy / Tobias Schmitz". Mainz : Universitätsbibliothek Mainz, 2016. http://d-nb.info/1112150870/34.
Testo completoTodd, Jean Ann. "Platinum(II) complexes containing 1,2- and 1,7-carborane ligands for boron neutron capture therapy". Title page, contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09PH/09pht634.pdf.
Testo completoAlfuraih, Abdulrahman. "Exploring the use of high energy medical linear accelerator in boron neutron capture therapy". Thesis, University of Surrey, 2009. http://epubs.surrey.ac.uk/843807/.
Testo completoLiu, Liang. "Development and Evaluation of Boron Targeting Agents For Neutron Capture Therapy of Brain Tumors /". The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487932351057135.
Testo completoWoollard, Jeffrey E. "Optimization of a moderator assembly for use in an accelerator-based neutron source for boron neutron capture therapy /". The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487945744571817.
Testo completoKlee, Kathleen A. "Optimization of an Epi-thermal neutron beam and beam dosimetry for boron neutron capture therapy at the Georgia Tech Research Reactor". Diss., Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/16405.
Testo completoOlusanya, Temidayo Olajumoke Bolanle. "Formulation and preliminary evaluation of delivery vehicles for the boron neutron capture therapy of cancer". Thesis, University of Portsmouth, 2015. https://researchportal.port.ac.uk/portal/en/theses/formulation-and-preliminary-evaluation-of-delivery-vehicles-for-the-boron-neutron-capture-therapy-of-cancer(595b381c-50cc-4a49-9c20-4850a01a43f1).html.
Testo completoCalabrese, Gianpiero. "Design, synthesis and preliminary in vitro evaluation of potential agents for Boron Neutron Capture Therapy". Thesis, University of Portsmouth, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.478899.
Testo completoGao, Wei Ph D. "Lithium-6 filter for a fission converter-based Boron Neutron Capture Therapy irradiation facility beam". Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/34653.
Testo completoThesis (S.M.)--Massachusetts Institute of Technology, Dept. of Nuclear Engineering, 2005.
(cont.) A storage system was designed to contain the lithium-6 filter safely when it is not in use. A mixed field dosimetry method was used to measure the photon, thermal neutron and fast neutron dose. The measured advantage depth is 9.3 ± 0.1cm without filter and 9.9 ± 0.1cm with 8mm lithium-6 filter. The result is consistent with the result of Monte Carlo calculation.
The design of a lithium-6 filter to be used in Boron Neutron Capture Therapy was developed. The lithium-6 filter increases the average energy of the epithermal neutrons in the epithermal neutron beam. This filter allows the beam to be used for effective BNCT treatment at greater depth in tissue. Based on Monte Carlo calculations, 8mm thick lithium-6 filter was found to be the optimum filter thickness for the MIT fission converter based epithermal neutron beam (FCB). The highly reactive lithium metal filter is sealed with aluminum covers against the humidity and surrounding air. A well shielded and convenient frame was also designed to hold the lithium-6 filter. The frame is separated into two parts. The fixed part of the frame will be mounted into the patient collimator of the FCB and provides a slot for the lithium-6 filter. The filter itself will be connected to the movable part of the frame and slid in and out of the beam through a pair of roller bearing tracks like a vertical drawer. Both parts of the frame are built with borated polyethylene (RICORAD) and steel to insure good shielding. Many safety issues have been considered in the design including tritium production, nuclear heating, pressure from released gases and radiation leakage on the side of the collimator.
by Wei Gao.
S.M.
Ko, Naonori. "Establishment of quality assurance and quality control measures for Boron Neutron Capture Therapy using microdosimetry". Kyoto University, 2020. http://hdl.handle.net/2433/253277.
Testo completoSuzuki, Minoru. "The effects of boron neutron capture therapy on liver tumors and normal hepatocytes in mice". Kyoto University, 2001. http://hdl.handle.net/2433/150526.
Testo completoLuguya, Raymond Joseph. "Syntheses of novel porphyrin, chlorin, and corrole macrocycles for application in boron neutron capture therapy and photodynamic therapy /". For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.
Testo completoDegree granted in Chemistry. Dissertation completed in 2004; degree granted in 2005. Also available via the World Wide Web. (Restricted to UC campuses).
Byun, Youngjoo. "Thymidine kinase as a molecular target for the development of novel anticancer and antibiotic agents". Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1149008350.
Testo completoGupta, Nilendu. "Fabrication and preliminary testing of a moderator assembly for an accelerator-based neutron source for boron neutron capture therapy /". The Ohio State University, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487867541731792.
Testo completoRogus, Ronald D. (Ronald Daniel). "Design and dosimetry of epithermal neutron beams for clinical trials of boron neutron capture therapy at the MITR-II reactor". Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/12280.
Testo completoWang, Chang-Kwang Chris. "A pilot study of an epithermal neutron source based on a low-energy proton accelerator for boron neutron capture therapy /". The Ohio State University, 1989. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487672631600438.
Testo completoWhite, Susan Marie 1973. "Beam characterization for accelerator-based boron neutron capture therapy using the ⁹Be(d,n) nuclear reaction". Thesis, Massachusetts Institute of Technology, 1998. http://hdl.handle.net/1721.1/50491.
Testo completoIncludes bibliographical references (leaves 62-65).
Use of the ⁹Be(d,n) nuclear reaction for accelerator-based boron neutron capture therapies (AB-BNCT) was investigated. The moderated neutron spectra produced at several deuteron bombarding energies were evaluated in terms of dose rates and dosimetric profiles in a water-filled brain phantom using an existing heavy water moderator and lead reflector assembly. Dosimetry results were obtained using the dual ionization chamber technique coupled with bare and cadmium-covered gold foils. Data have been taken with deuteron beams of 1.3 MeV to 1.8 MeV. As deuteron energy was increased, the tumor dose rate correspondingly improved due to the neutron yield increase. However, the data suggest that the advantage depth decreased, and the ratio of the fast neutron dose rate to the thermal neutron dose rate at a depth of I cm increased, although error bars are significant. All deuteron energies investigated produced a beam that, once moderated, appears viable for AB-BNCT. No conclusion was drawn about the best energy in terms of a high tumor dose rate, a significant advantage depth, and a low fast to thermal neutron dose rate ratio. Treatment times assuming 20 Gy to a tumor located 4 cm deep using a 4 mA accelerator ranged from 18 - 59 minutes, assuming a tumor boron concentration of 40 ppm and RBE values of 1.0 for photons, 3.2 for neutrons, and 3.8 for boron in tumor tissue. The average advantage depth was 6.4 ± 0.7 cm, so these moderated beams could be used to treat tumors near the brain centerline. The ⁹Be(d,n) nuclear reaction is exothermic, and is accessible to inexpensive, small particle accelerators.
by Susan Marie White.
S.M.
Ryynänen, Päivi. "Kinetic mathematical modesl for the 111In-labelled bleomycin complex and 10B in boron neutron capture therapy". Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/fysik/vk/ryynanen/.
Testo completoNiemkiewicz, John. "A study on the use of removal-diffusion theory to calculate neutron distributions for dose determination in boron neutron capture therapy /". The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487934589976468.
Testo completoMAGNI, CHIARA. "Experimental and computational studies for an Accelerator-Based Boron Neutron Capture Therapy clinical facility: a multidisciplinary approach". Doctoral thesis, Università degli studi di Pavia, 2022. http://hdl.handle.net/11571/1447823.
Testo completoMANGUEIRA, THYAGO F. "Avaliacao dosimetrica da solucao fricke gel usando a tecnica de espectrofotometria para aplicacao na dosimetria de eletrons e neutrons". reponame:Repositório Institucional do IPEN, 2009. http://repositorio.ipen.br:8080/xmlui/handle/123456789/9447.
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Dissertacao (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
Roux, Lionel. "Conception et synthèse d'inhibiteurs de l'Aminopeptidase membranaire N ([EC. 3.4.11.2], APN ou CD13)". Thesis, Mulhouse, 2010. http://www.theses.fr/2010MULH4691/document.
Testo completoThe fight against the cancer is one of the most important struggles of this century. For the development of the tumors inside the body, they need to receive nutriments by the blood vessels and they use the angiogenic process. During this process, the endothelial cells being shown on the wall of the blood vessel will multiply and design new blood vessel, which will allow the tumor's vascularisation. Today, the angiogenesis is an axis of research for the fight against the cancer. During the tumoral development, the aminopeptidase N (APN) is overexpressed on the wall of endothelial cells. Various studies have shown that the inhibition of this enzyme stops the tumoral progression. My work in the Pr. Céline Tarnus Team consists in the conception and the synthesis of APN's inhibitors. In a first time, a structure activity relationship has been realized. Syntheses of a subnamolar compound have been developed, and then the synthesis of APN's inhibitors with the use of BNCT has been got onto
Sakamoto, Shuichi. "Sensitivity studies of the neutronic design of a fission converter-based ephithermal beam for boron neutron capture therapy". Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/46089.
Testo completoGibson, Christopher R. "Pharmacokinetics, metabolism, and dose optimization simulation studies of Sodium Borocaptate for Boron Neutron capture therapy of Malignant Gliomas /". The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu148639916010674.
Testo completo