Tesi sul tema "Bones – Diseases"
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Cheng, Tak Sum. "Molecular identification and characterization of novel osteoclast V-ATPase subunits". University of Western Australia. School of Surgery and Pathology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0068.
Testo completoVan, Greunen Francois. "Microcomputer-assisted diagnosis of inherited disorders of the skeleton". Master's thesis, University of Cape Town, 1988. http://hdl.handle.net/11427/25754.
Testo completoFoster, Bruce Kristian. "Epiphyseal plate repair using fat interposition to reverse physeal deformity : an experimental study". Title page, contents and summary only, 1989. http://web4.library.adelaide.edu.au/theses/09MD/09mdf754.pdf.
Testo completoAlbogami, Mohammed Mater. "Bone loss in osteoporosis and rheumatoid arthritis diseases : the effects of disease mechanisms, age, gender and ethnic origin on responsiveness to treatment". Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8901.
Testo completoWhitton, Robert Christopher. "Carpal disease in racing horses". Thesis, The University of Sydney, 1997. https://hdl.handle.net/2123/26702.
Testo completoKarunaratne, Malintha P. Angelo. "Analysis of alterations in matrix quality at nanoscale in metabolic bone diseases using synchrotron X-ray diffraction". Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/8490.
Testo completoAlmasabi, Abeer. "Determination of Hydroxyproline in Bone Collagen: Potential Application as a Biomarker for Bone Diseases". Thesis, Université d'Ottawa / University of Ottawa, 2018. http://hdl.handle.net/10393/38420.
Testo completoLiang, Chao. "Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA Interference-based bone anabolic strategy". HKBU Institutional Repository, 2016. https://repository.hkbu.edu.hk/etd_oa/325.
Testo completoVasseleu, Cathryn. "Cleidocranial dysplastic mutant in the mouse : dental findings". Thesis, The University of Sydney, 1986. https://hdl.handle.net/2123/26032.
Testo completoBjörnsdóttir, Sigrídur. "Bone spavin in Icelandic horses : aspects of predisposition, pathogenesis and prognosis /". Uppsala : Dept. of Clinical Radiology, Swedish Univ. of Agricultural Sciences ([Institutionen för klinisk radiologi], Sveriges lantbruksuniv, 2002. http://epsilon.slu.se/avh/2002/91-576-6382-3.pdf.
Testo completoWang, Cathy Ting-Peng. "Molecular dissection of RANKL signaling pathways in osteoclasts". University of Western Australia. School of Surgery and Pathology, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0037.
Testo completoPayne, Scott Andrew. "An Electron Energy-Loss Spectroscopic Investigation of Molecular Interactions at Hydroxyapatite-Collagen Interfaces in Healthy and Diseased (Osteogenesis Imperfecta) Human Bone and Biomineralized Tissue-Engineered Bone". Diss., North Dakota State University, 2018. https://hdl.handle.net/10365/27928.
Testo completoNational Science Foundation under Grant Nos. 0619098, 0821655, 0923354, and 1229417
Dang, Lei. "Osteoblastic PLEKHO1 contributes to joint inflammation in rheumatoid arthritis". HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/687.
Testo completoFernandes, Fernanda [UNESP]. "Análise do colo femoral de ratas adultas e senis após tratamento com ocitocina". Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/143823.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Este estudo teve como objetivo analisar e comparar a ação da ocitocina (OT) no metabolismo ósseo de ratas Wistar cíclicas (12 meses) e acíclicas (18 meses/período de periestropausa). Os animais foram distribuídos em quatro grupos: (1) animais com 12 meses que receberam injeção com veículo NaCl (Veh/12); (2) animais com 12 meses que receberam injeção de OT (Ot / 12); (3) animais com 18 meses que receberam injeção com veículo NaCl (Veh/18); (4) animais com 18 meses que receberam injeção de OT (Ot / 18). Cada grupo foi composto por 8 animais. Os animais receberam duas injeções intraperitoneais de NaCl (0,15 M – grupo controle) ou OT (134 ug / kg – grupo tratado) com 12 horas de intervalo. Força, microarquitetura e biomarcadores ósseos [fosfatase alcalina (FAL) e fosfatase ácida resistente ao tartarato (TRAP)] foram analisados. Imunoistoquímica foi realizada para fator de transcrição relacionado com o Runt 2 (RUNX2), osterix (OSX), osteocalcina (OCN), osteopontina (OPN), proteína óssea morfogenética 2 e 4 (BMP-2/4), periostina (PER), esclerostina (ESC) e TRAP. Os animais que receberam OT demonstraram melhora significante na dosagem plasmática: aumento na FAL dos animais de 12 meses (p < 0,0001) e 18 meses (p = 0,0138); diminuição na TRAP dos animais de Ot / 12 (p = 0,0465) e Ot / 18 (p = 0,0045). Houve melhora nos parâmetros biomecânicos: força máxima (N) do grupo Ot / 18 (p = 0,0003); rigidez óssea (x103N/mm) do grupo Ot / 12 (p = 0,0223) e Ot / 18 (p = 0,0145); microarquitetura óssea cortical do grupo Ot / 18 para Ct.Ar (mm2 ) (p = 0,0416) e Ct.Po (%) (p = 0,0102); microarquitetura óssea trabecular para Tb.N (1/mm) (p = 0,0016) e Tb.Sp (p = 0,00010); todos os grupos foram comparados ao seus respectivos controles (Veh/12; Veh/18). Em resumo, os resultados demonstraram que a administração de OT foi eficaz para prevenir a perda de massa óssea em ratas Wistar velhas com hipoestrogenismo, reforçando este agente anabólico como forte alternativa terapêutica para prevenção e tratamento da osteoporose (OP), reduzindo os índices da doença e fraturas osteoporóticas.
This study aimed to analyze and compare the acting of oxytocin (OT) on bone metabolism of cyclic (12 months) and acyclic Wistar rats (18 months/peri-estropause period). Animals were allocated to four groups: (1) animals with 12 months that received vehicle injection NaCl (Veh/12); (2) animals with 12 months that received OT injection (Ot / 12); (3) animals with 18 months that received vehicle (Veh/18) and (4) animals with 18 months that received OT injection (Ot / 18). Eight animals composed each group. The animals received two intraperitoneal injections of NaCl (0.15 M - control group) or OT (134 ug / kg - treated groups) with 12 hours apart. Bone strength, microarchitecture, and biomarkers [alkaline phosphatase (ALP) and tartrate-resistant acid phosphatase (TRAP)] were assessed. Immunohistochemistry was performed for runt-related transcription factor 2 (RUNX2), osterix (OSX), osteocalcin (OCN), osteopontin (OPN), bone morphogenetic protein 2 and 4 (BMP- 2/4), periostin (PER), sclerostin (ESC) and TRAP. Animals that received OT showed significant improvements at plasma assay: increase in the ALP from the animals with 12 months (p < 0.0001) and 18 months (p = 0.0138); decrease in the TRAP from the Ot / 12 (p = 0.0465) and Ot / 18 (p = 0.0045). There was improvements at biomechanical parameters: maximum load (N) from the Ot / 18 (p = 0.0003); bone stiffness (x103N/mm) from the Ot / 12 (p = 0.0223) and Ot / 18 (p = 0.0145); cortical bone microarchitecture from the Ot / 18 to Ct.Ar (mm2 ) (p = 0.0416) and Ct.Po (%) (p = 0.0102); trabecular bone microarchitecture to Tb.N (1/mm) (p = 0.0016) and Tb.Sp. (p = 0.00010); all groups compared to its respective controls (Veh/12; Veh/18). In summary, the results showed the OT administration was effective to prevent the bone loss in old Wistar rats with hypoestrogenism, reforcing this anabolic agent as powerful therapeutic alternative to prevention and treatment for osteoporosis (OP), to reduce the rates of disease and osteoporotic fractures.
CNPq: 133834/2014-0
Cha, Ming Chuan 1955. "The effect of zinc deficiency on the growth promoting actions of growth hormone and insulin-like growth factor-I /". Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55484.
Testo completoAlfonso, Durruty Marta Pilar. "Biosignificance of Harris lines as stress markers in relation to moderate undernutrition and bone growth velocity a New Zealand white rabbit model for the study of bone growth /". Diss., Online access via UMI:, 2008.
Cerca il testo completoChan, Cheuk-wing Wilson, e 陳卓榮. "ER stress in the pathogenesis of osteochondrodysplasia". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43085192.
Testo completoPatel, Mamta Jashvantlal. "Suppression of osteoblast activity by disuse is prevented by low magnitude mechanical loading through a bone morphogenic protein-dependent Mechanism". Diss., Georgia Institute of Technology, 2008. http://hdl.handle.net/1853/22663.
Testo completoBiason, Talita Poli [UNESP]. "Densidade mineral óssea em adolescentes usuárias de anticoncepcional oral combinado". Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/99233.
Testo completoAvaliar a densidade mineral óssea (DMO) e o conteúdo mineral ósseo (CMO) de adolescentes do sexo feminino, usuárias de anticoncepcional oral combinado (AOC) de baixa dosagem padronizado (EE 20 μg/ Desogestrel 150 μg), por período de um ano de seu uso e comparar os dados obtidos aos de adolescentes saudáveis da mesma faixa etária, não usuárias. Trata-se de um estudo controlado paralelo não randomizado. Sessenta e sete adolescentes, de 12 a 20 anos de idade, foram divididas em grupo de usuárias de AOC (n=41) e grupo controle (n=26). As adolescentes pertencentes aos dois grupos foram submetidas a exame físico geral e especial para obtenção de peso, estatura, índice de massa corpórea (IMC), avaliação dos caracteres sexuais secundários (critérios de Tanner), obtenção de idade óssea (IO) pelo método de Greulich & Pyle, ingestão de cálcio obtida pelo recordatório de 3 dias e obtenção da idade do evento menarca. As usuárias de AOC foram submetidas ao exame de Densitometria Óssea por atenuação de raio x de dupla energia (DXA), no momento de inclusão no trabalho; 6 e 12 meses depois, para obtenção de CMO (g) e DMO (g/cm2) em região lombar (L1-L4), fêmur proximal total, corpo total e corpo subtotal. O grupo controle foi avaliado através da DXA, no momento inicial; 12 meses depois, para obtenção de DMO e CMO, nos mesmos locais. A comparação entre as variáveis dos grupos de não usuárias e usuárias de AOC, no momento zero, foi realizada através do teste de Mann-Whitney, fixado o nível de significância de 5% ou utilizado o p-valor correspondente, enquanto para a comparação evolutiva dos grupos utilizou-se a variação das porcentagens das medianas das variáveis relativas à massa óssea, nos momentos inicial e final. Não houve diferenças estatísticas nas comparações entre as idades cronológicas (IC) e IO, entre as variáveis antropométricas e as resultantes do...
To evaluate bone mineral density (BMD) and bone mineral content (BMC) in female adolescents taking a standard low dose (EE 20μg/ Desogestrel 150μg) combination oral contraceptive (COC) over a one year period and comparing them to healthy adolescents from the same age group not taking COC’s. A non-randomized parallel control study with 67 adolescents from 12 to 20 years of age divided into user (COC; n=41) and control (n=26) groups. Both groups were submitted to a general physical and specific examination for weight, height, body mass index (BMI), secondary sexual characteristics evaluation (Tanner criteria), bone age (BA) by the Greulich & Pyle method, calcium intake by 3 days diet recording, and obtaining age at menarche. COC users underwent bone density exam by dual-energy X-ray absorptiometry (DXA) at time of inclusion in the study and at 6 and 12 months, to obtain BMC (g) and BMD (g/cm2) in the lumbar (L1-L4) and total proximal femur regions, for whole body and subtotal whole body. The Control group underwent DXA at inclusion and 12 months to obtain BMD and BMC in the same locations. Comparisons between groups at moment zero was through the Mann-Whitney test with significance level fixed at 5% or corresponding p value; evolutive group comparisons used variations in median percentages for bone mass variables at start and final moments. There were no statistical differences in chronological (CA) and BA, anthropometric variables, and bone densitometry results at the initial moment between COC and control groups. However after 12 months follow-up, COC users presented low bone mass acquisition in the lumbar spine BMD and BMC median variation percentages between initial and final moments (+2.07% and +1.57% respectively) while the control group presented expressive variations (+12.16% and +16.84% respectively). Total body BMD and BMC presented similar behaviour; variation in the COC group was +0.84% and +1.22%, considerably lower ...
Valverde, Franco Gladys 1972. "The role of fibroblast growth factor receptor 3 in post-natal cartilage and bone metabolism /". Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115917.
Testo completoPedroni, Marcus Vinícius Costa 1985. "Análise molecular e funcional dos genes formadores e reguladores do colágeno tipo I em pacientes com osteogênese imperfeita = Molecular and functional analysis of regulatory and structure-related genes of type I collagen in patients with osteogenesis imperfecta". [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310406.
Testo completoDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências
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Resumo: A Osteogênese Imperfeita (OI) é um distúrbio genético caracterizado por baixa massa e fragilidade óssea, e outras manifestações do tecido conjuntivo, decorrente de defeitos qualitativos ou quantitativos do colágeno tipo I. Está associada a mutações nos genes COL1A1 e COL1A2 que codificam respectivamente as cadeias pro'alfa'1-(I) e pro'alfa'-2(I) formadoras da molécula do colágeno tipo I, e mais raramente mutações nos genes reguladores. A OI manifesta-se através de diferentes fenótipos (I-IV), segundo a classificação de Sillence et al. O objetivo deste trabalho foi a análise molecular dos genes COL1A1 e COL1A2 em famílias brasileiras portadoras de OI, em suas diferentes formas clínicas. Fizemos biópsia da pele de 12 famílias com OI para cultura primária dos fibroblastos. Desta cultura extraímos RNA total, que foi usado como molde para transcrição reversa e reação em cadeia de polimerase (PCR) dos genes e sequenciamento automático direto de cDNA. A expressão gênica foi determinada por Real Time PCR e o padrão e grau de expressão das proteínas do colágeno foram analisados por Imunocitoquímica e Western blot. Identificamos nove mutações missense em heterozigose em nove famílias, e duas mutações com alteração na matriz de leitura em famílias com fenótipos dos tipos I, III ou IV de OI. No gene COL1A1 encontramos quatro mutações já descritas: c.613G>A (p.P205A); c.769G> A (p.G257R); c.859G>A (p.G287S); c.1678G>A (p.G560R). No gene COL1A2 encontramos uma mutação já descrita: c.2314G> A (p.G772S) e quatro novas mutações: c.214G>A (p.G72S); c.775G>A (p.G259S); c.793G> C (p.G265R) e c.3467G>A (p.R1156K). Encontramos hiperexpressão dos transcritos de COL1A1 e COL1A2, porém expressão normal das cadeias 'alfa'1 e 'alfa'2 da proteína do colágeno em todos os pacientes. As cadeias mutada apresentaram padrão desorganizado nas células. Pacientes com OI apresentaram hiperexpressão dos genes de colágeno tipo I sugerindo que estes genes são regulados e que as meia vidas destas proteínas estão reduzidas
Abstract: Osteogenesis Imperfecta (OI) is a genetic disorder characterized by low bone mass and bone fragility, and other manifestations of connective tissue, due to qualitative or quantitative defects of type I collagen. It is associated with mutations in COL1A1 and COL1A2 genes, that encode respectively the pro'alpha'-1(I) and pro'alpha'-2(I) chains, forming the molecule of type I collagen, and more rarely mutations in regulatory genes. The OI is manifested by various phenotypes (I-IV), according to the classification of Sillence et al. The objective of this study was the molecular analysis of COL1A1 and COL1A2 genes in Brazilian families with OI, in its different clinical forms. We performed skin biopsy from 12 families with OI for primary culture of fibroblasts. From this culture, we made total RNA extract, which was used as template for reverse transcription and polymerase chain reaction (PCR), and automated sequencing directly from cDNA. Gene expression was determined by Real Time qPCR and the level of expression of collagen proteins were analyzed by immunocytochemistry and Western Blot. We identified heterozygous mutations in 11 families that have phenotypes of types I, III or IV of OI. In the COL1A1 gene found four previously described mutations: c.613G> A (p.P205A), c.769G> A (p.G257R), c.859G> A (p.G287S), c.1678G> A (p. G560R). In the COL1A2 gene we found one previously described mutation: c.2314G> A (p.G772S) and four new mutations: c.214G> A (p.G72S), c.775G> A (p.G259S), c.793G> C (p.G265R) and c.3467G> A (p.R1156K). We found upregulation of the transcripts of COL1A1 and COL1A2 genes, but a normal expression of 'alpha'1 and 'alpha'2 protein chains in all patients. The mutant chain showed disorganized on the immunocytochemestry. Patients with OI showed upregulation of type I collagen genes, suggesting regulation and decreasing half lives of the proteins
Mestrado
Saude da Criança e do Adolescente
Mestre em Ciências
Neves, Camila de Castro [UNESP]. "Estudo radiográfico retrospectivo de lesões ósseas mandibulares em cães". Universidade Estadual Paulista (UNESP), 2006. http://hdl.handle.net/11449/89086.
Testo completoUniversidade Estadual Paulista (UNESP)
Com o presente estudo relata-se a freqüência, localização e tipo de alterações encontradas em 77 cães com suspeita de lesão óssea na mandíbula, em imagens radiográficas, do arquivo do Setor de Radiologia do Hospital Veterinário Governador Laudo Natel (HV), da Faculdade de Ciências Agrárias e Veterinárias, da Universidade Estadual Paulista (FCAV/UNESP), Câmpus de Jaboticabal, SP, no período de janeiro de 2001 a janeiro de 2006, correlacionando sexo, idade e raça dos animais. A pesquisa revelou 37 (48,05%) cães com lesões mandibulares. Dentre os cães acometidos 44,16% eram de raça indefinida e 14,29% da raça Poodle. Do total 33,77% eram machos e a idade mais afetada estava entre seis e nove anos (23,38%). A fratura (38,96%) foi à alteração mais encontrada e o local de maior ocorrência foi à região de premolares (24,38%) e molares (10,39%) do corpo da mandíbula.
The present study reported the frequency, placement and kind of changes in 77 dogs supposed to have lesions at jawbone in radiographic images from the Radiological Sector archive, at the Veterinary Hospital Governador Laudo Natel (HV), of the Veterinary Faculty from São Paulo State University (FCAV/UNESP), Jaboticabal, SP, between January 2001 to January 2006, correlating sex, age and the breed of the animals. The study revealed 37 (48, 5%) of dogs with jawbone lesions. Among the dogs that were taken ill, 44,16% had no defined breed and 14,29% were Poodle. They were 33,7% male and the most affected age range was between six and nine (23,38%). The fracture (38,96%) was the most common change and it occurred most frequently in the premolar region (10,39%) and molar region (10,39%) of the mandible body.
Costin, Graham A. "Skeletal health education : effects of an educational intervention on health behaviour and health behaviour indicators of adolescent girls". Thesis, Queensland University of Technology, 1998.
Cerca il testo completoTag, Naima. "The added value of SPECT/CT in complicated osteomyelitis". Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85553.
Testo completoAFRIKAANSE OPSOMMING: Agtergrond: Die opspoor van beeninfeksie is veral moeilik in been wat as gevolg van vorige trauma of chirurgiese prosedures misvorm is. Gekompliseerde osteomiëlitis word ‘n gesondheidsprobleem veral as gevolg van die moeilike keuse tussen hoë koste chirurgie en langdurige kursusse binneaarse of orale antibiotika, asook die sosiale en sielkundige gevolge van langstaande siekte en die gestremdheid van die pasiënt. Die korrekte lokalisering van veral beeninfeksie is steeds ‘n uitdaging vir die geneesheer. Enkel foton emissie rekenaartomografie / lae dosis rekenaartomografie (SPECT/CT), die kombinasie van funksionele en anatomiese inligting, is ‘n goed gevestigde metode in baie kerngeneeskunde ondersoeke. Dit verbeter die algemene kwaliteit van die studie met ‘n meer spesifieke antwoord. Die doel van hierdie studie was om die bykomende waarde van SPECT/CT in die hantering van gekompliseerde osteomiëlitis in pasiënte met endo-protese, post traumatise osteomiëlitis met en sonder metaal prosteses asook diabetiese voet te bepaal. Metode: ‘n Prospektiewe studie is tussen Februarie 2010 en Februarie 2012 gedoen. Pasiënte met vermoedelik gekompliseerde osteomiëlitis wat aan die keuse en insluitingskriteria voldoen het, is ingesluit. Almal het abnormale drie-fase beenflikkergramme gehad, gevolg deur infeksiebeelding met 99mTc gemerkte witselle en 99mTc kolloïed indien die 99mTc gemerkte witselstudie abnormaal was. 67Ga sitraat is gebruik wanneer daar werwelaantasting teenwoordig was. Die planare en SPECT/CT beelde is vergelyk ten opsigte van diagnose en presiese lokalisering van die infeksie. Die finale diagnose is met behulp van chirurgiese monsters en mikrobiologiese kweking asook die kliniese opvolg van alle pasiënte bepaal. Resultate: Die studie het 72 pasiënte, 29 mans en 43 vroue, met gemiddelde ouderdom van 57 jaar [27 – 88 ingesluit]. Daar was 24 pasiënte met prosteses, waarvan 16 met heupprosteses (PH= 16) en 8 met knieprosteses (PK= 8). Van die 44 pasiënte met post traumatiese osteomiëlitis, het 26 metaal prosteses (TOM= 26) en 18 geen metaalprosteses gehad nie (TOWM= 18). Vier pasiënte het diabetiese voet gehad (DF= 4). By 19/72 van die pasiënte is infeksie op die planare beelde gediagnoseer en in 21/72 op die SPECT/CT beelde. Die bykomende twee gevalle was 1 met TOM en 1 met TOWM. Infeksie is by 4 pasiënte met prosteses, 16 pasiënte met post traumatiese besering en 1 met diabetiese voet gediagnoseer. In die vier pasiënte met prosteses, het SPECT/CT ‘n diagnostiese bydrae gelewer om osteomiëlitis by 3 van die pasiënte uit te skakel en die presiese omvang en lokalisering van sagte weefsel en beeninfeksie (STI/OM) in een pasiënt te bepaal. In 16 pasiënte met post traumatise osteomiëlitis op die planare beelde, was SPECT/CT van diagnostiese waarde, waar osteomiëlitis in 4 pasiënte uitgesluit is, en slegs STI bevestig is. Beter lokalisering van die opname in been en sagte weefsel was in 5 pasiënte moontlik, van wie 2 op die planare beelde negatief was, en in 7 pasiënte bevestig en die presiese omvang met beide OM en STI gedefinieer is. Een diabetiese voet was positief vir STI op die planare beelde, maar die SPECT/CT het diagnostiese waarde verbeter deur die omvang van die infeksie beter te toon. Ter opsomming, was die waarde van die SPECT/CT: 1. Uitsluiting van osteomiëlitis deur slegs van sagte weefsel aantasting te bevestig: 7 pasiënte 10% 2. Beter lokalisering in been en sagte weefsel: 5 pasiënte 7% 3. Beter definisie van omvang van infeksie: 9 pasiënte 12% 4. Geen bykomende waarde: 51 pasiënte 71% Die algehele sensitiwiteit, spesifisiteit, positiewe voorspellingswaarde, negatiewe voorspellingswaarde en akkuraatheid vir die opspoor van infeksie vir die planare beelde was 90%, 100%, 100%, 97%, 97%, onderskeidelik en vir die SPECT/CT 100%, 100%, 100%, 100% en 100%. Vir osteomiëlitis was sensitiwiteit, spesifisiteit, positiewe voorspellingswaarde, negatiewe voorspellingswaarde en akkuraatheid van planare beelde 100%, 89%, 53%, 100%, 90%, onderskeidelik en die van SPECT/CT 100%, 100%, 100%, 100% , 100%. Gevolgtrekking: SPECT/CT is nuttig in die lokalisering en definiëring van die presiese omvang van die infeksie in gekompliseerde osteomiëlitis in gevalle waar die planare beelde abnormaal is, met geen bykomende waarde wanneer planare beelde negatief is nie. Ons beveel SPECT/CT beelding as roetine in kliniese praktyk aan wanneer planare beelde in gekompliseerde osteomiëlitis abnormaal is.
周志豪. "跟痛症內服中藥治療規律的文獻研究". HKBU Institutional Repository, 2009. http://repository.hkbu.edu.hk/etd_ra/1042.
Testo completo譚健斌. "股骨頭缺血性懷死的中醫藥治療文獻研究". HKBU Institutional Repository, 2006. http://repository.hkbu.edu.hk/etd_ra/755.
Testo completoGuañabens, Gay Nuria. "Osteodistrofia de la cirrosis biliar primaria". Doctoral thesis, Universitat de Barcelona, 1987. http://hdl.handle.net/10803/22838.
Testo completoGoodyear, Simon R. "Physicochemical methods for measuring the properties of bone and their application to mouse models of disease". Thesis, University of Aberdeen, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=133992.
Testo completoNeves, Camila de Castro. "Estudo radiográfico retrospectivo de lesões ósseas mandibulares em cães /". Jaboticabal : [s.n.], 2006. http://hdl.handle.net/11449/89086.
Testo completoBanca: Júlio Carlos Canola
Banca: Jorge Luiz Oliveira Costa
Resumo: Com o presente estudo relata-se a freqüência, localização e tipo de alterações encontradas em 77 cães com suspeita de lesão óssea na mandíbula, em imagens radiográficas, do arquivo do Setor de Radiologia do Hospital Veterinário "Governador Laudo Natel" (HV), da Faculdade de Ciências Agrárias e Veterinárias, da Universidade Estadual Paulista (FCAV/UNESP), Câmpus de Jaboticabal, SP, no período de janeiro de 2001 a janeiro de 2006, correlacionando sexo, idade e raça dos animais. A pesquisa revelou 37 (48,05%) cães com lesões mandibulares. Dentre os cães acometidos 44,16% eram de raça indefinida e 14,29% da raça Poodle. Do total 33,77% eram machos e a idade mais afetada estava entre seis e nove anos (23,38%). A fratura (38,96%) foi à alteração mais encontrada e o local de maior ocorrência foi à região de premolares (24,38%) e molares (10,39%) do corpo da mandíbula.
Abstract: The present study reported the frequency, placement and kind of changes in 77 dogs supposed to have lesions at jawbone in radiographic images from the Radiological Sector archive, at the Veterinary Hospital Governador Laudo Natel (HV), of the Veterinary Faculty from São Paulo State University (FCAV/UNESP), Jaboticabal, SP, between January 2001 to January 2006, correlating sex, age and the breed of the animals. The study revealed 37 (48, 5%) of dogs with jawbone lesions. Among the dogs that were taken ill, 44,16% had no defined breed and 14,29% were Poodle. They were 33,7% male and the most affected age range was between six and nine (23,38%). The fracture (38,96%) was the most common change and it occurred most frequently in the premolar region (10,39%) and molar region (10,39%) of the mandible body.
Mestre
Mkhize, Felicity Nomfuzo. "Investigating the high incidence of bone disorders in a broiler farm : a case study". Thesis, Stellenbosch : University of Stellenbosch, 2006. http://hdl.handle.net/10019.1/3346.
Testo completoRickets is described as a disease that affects young growing poultry. Poorly mineralized bones with thickened and irregular growth plates characterize it. The onset of rickets is characterized by a failure of mineralization of cartilage and bone. Other symptoms of rickets include reluctance to movement in affected birds. These birds will sit on their hocks and if startled they use their wings for balance. On necropsy, bones are soft and fragile and they have thickened growth plates. In this study 30% of the chicks aged between 7 and 8 days from a broiler flock, started showing splay leg problems. Affected chicks were unable to support their weight on their legs, some showing paralysis. The bones were soft and rubbery. To try and identify the possible cause, bones from the affected chicks were analyzed for calcium (Ca) and phosphorus (P) to determine the Ca:P ratio. Blood serum was also analyzed for the mineral content. Ca and P were the main focus of the tests as the problem was suspected to be rickets. The feed was analyzed for protein, Ca and P. The bone analysis showed a Ca:P ratio of less than 2:1, while results of the blood serum showed an inverse Ca: P ratio. The analysis results of the feed as well as the bones showed an imbalance in the Ca:P ratio which according to literature and research done is a possible cause for rickets. These findings combined with the symptoms displayed by the affected birds, lead to the suggestion that the problem in this study was rickets.
Brock, Ryane Schmidt [UNESP]. "Retalho ósseo de gálea e periósteo preenchido com pó de osso: estido em coelhos". Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/87352.
Testo completoCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Defeitos ósseos decorrentes de traumas, ressecções de tumores ou mesmo malformações congênitas, são encontrados com freqüência na prática médica. O tratamento destas deformidades é feito mediante reconstruções cirúrgicas, principalmente na cirurgia plástica, proporcionando aos pacientes melhor qualidade de vida. Os defeitos ósseos são corrigidos preferencialmente com enxertos ósseos autológos por não causarem rejeição, mas estes apresentam como desvantagens a morbidade das áreas doadoras e a grande porcentagem de absorção dos enxertos, com diminuição ou perda do resultado final. Outros métodos de reconstrução, como o uso de materiais aloplásticos, são utilizados mas, muitas vezes, evoluem com rejeição e extrusão ou infecção, e necessitam ser retirados. Retalhos livres, compostos de osso com músculo ou derme e subcutâneo, em casos graves, representam a melhor opção. Entretanto, este método requer preparo específico da equipe cirúrgica, maior tempo de cirurgia e, muitas vezes, apresenta trombose vascular e perda do retalho. Avaliar a viabilidade e a formação óssea em retalho gáleoperiostal preenchido com pó de osso em calota craniana de coelhos. Foram estudados 40 coelhos divididos em dois grupos, o primeiro com retalho gáleo-periostal e o segundo com o mesmo retalho, porém preenchido com pó de osso. Os resultados demonstraram neoformação óssea em ambos, mas com diferenças na estrutura e conformação óssea. O retalho gáleo-periosteal preenchido com pó de osso em calota craniana de coelhos é viável. A formação óssea ocorreu em ambos os grupos, preenchido ou não com pó de osso. A maturidade do tecido ósseo foi maior nos retalhos preenchidos com pó de osso
Osseus defects from traumas, tumor ressections or congenital malformations are usual in medical practice. The treatment of these deformities has been made with reconstructive surgeries, specially in plastic surgery, to give the patients better quality of life. The osseus defects are usually corrected with autologous bone grafts. These grafts are used because they do not cause rejection. However, they have disadvantages like the donnor site morbidity, the high number of absorption of these grafts and the final result partial or total lost. Other reconstruction methods like alloplastic materials are used, but they have high percentage of rejection and extrusion or even infection of these materials, which need to be taken off. Flaps of bone and muscle or dermis and subcutaneous are considered the best choice in difficult cases. However, this method needs specific training of the medical group, longer surgeries and, sometimes, presents the flap necrosis after vascular thrombosis. To study the viability and bone neoformation in a vascularized galea and periosteum flap filled with bone fragments. Fourty rabbits were studied, and divided into two groups. One had a simple galea and periosteum flap done and the other had the same flap done but filled with bone fragments of the calvaria. The results demonstrated bone formation in both groups, but with differences in the bone form and structure. The galea-periosteum flap filled with bone dust at rabbit’s calvaria is viable. The bone formation happened in both groups, with or without bone dust. Bone maturity was higher in the flaps filled with bone dust
Aguiar, Simone dos Santos. "Pesquisa da amplificação e/ou deleção genica atraves da tecnica de hibridização genomica comparativa (CGH) e da leção dos genes P53 e RB1 atraves da tecnica de hibridação in situ fluorescente (FISH) no tecido do tumor de crianças e adolescentes com ost". [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312071.
Testo completoTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-06T21:43:20Z (GMT). No. of bitstreams: 1 Aguiar_SimonedosSantos_D.pdf: 43958145 bytes, checksum: b9dafbbd99ad0e567b3c1f03a0c7b37e (MD5) Previous issue date: 2006
Resumo: Introdução Os osteossarcomas (OS) são tumores agressivos, primários de osso, com prognóstico reservado. As deleções dos genes supressores de tumor, RBl e P53, localizados nos cromossomos 13 e 17 respectivamente, são freqüentemente encontradas neste tipo de tumor. As alterações citogenéticas encontradas nos OS são de alta complexidade, porém nenhuma delas é recorrente, não podendo caracterizá-lo. A técnica da Hibridização Genômica Comparativa (CGH) é uma ferramenta muito precisa para o estudo das deleções e amplificações gênicas ocorridas neste tumor. Materiais e Métodos. Tecido tumoral de 41 crianças com OS foi analisado pela técnica de CGH para pesquisar possíveis ganhos e/ou perdas gênicas . A técnica da Hibridização In Situ Fluorescente (FISH) foi realizada para estudar as deleções dos genes P53 e RBl. Vinte e quatro pacientes eram do sexo feminino e 17 do sexo masculino, com mediana de 12 anos e 4 meses. Resultados. As anormalidades cromossômicas observadas com a técnica de CGH foram diversas e variadas, especialmente ganhos nos cromossomos lp, 2p, 3q, 5q,5p e 6p e, perdas nos cromossomos 14q (50% no - 14q 11.2), 15q e 16p. Alto índice de perdas foi observado no cromossomo 21 (26 de 41 casos; p=0,008), sendo a região mais freqüentemente afetada a 21ql 1.2. Com relação ao estudo dos supressores tumorais, a deleção do P53 ocorreu em 68,3% dos casos (p=0,02) e do RBl em 87,5% dos casos (p=0,000001). Conclusão. Apesar de ambos supressores (PS3 e RBl) estarem deletados na maioria dos pacientes, este evento parece não estar associado ao prognóstico. Anormalidades ainda não reportadas presentes no cromossomo 21 nos OS pediátricos, sugerem que a seqüência mapeada nesta região cromossômica possa estar envolvida na patogênese deste tumor
Abstract: Background. Osteosarcomas (OS) are aggressive bone tumors and often have a poor prognosis. It is already known that abnormalities in chromosomes 13 and 17 are frequently observed in OS patients, being also expected a deletion of RBI and P53 genes. The tumors exhibit karyotypes with a high degree of complexity, that has made it difficult to determine if any recurrent chromosomal aberrations could characterize OS. To address inherent difficulties associated with classical cytogenetic analysis, comparative genomic hybridization (CGH) has been applied to OS tissue. Patients and Methods. Forty one pediatric OS specimens were analyzed by CGH techniques, and the expression of RBI and P53 were analyzed by FISH . Twenty four patients were girls and 17 boys. Median age was 12 years and 4 months.Results. Chromosomal abnormalities were highly diverse and variable specially gains in chromosome lp, 2p, 3q, 5q , 5p and 6p and losses in chromosome 14q (50% in - 14q 11.2), 15q and 16p. High level of losses in chromosome 21 were present (26 of 41 cases; p-0,008), being 21 q 11.2 region the most frequent one. Concerning about genes expression, P53 is deleted in 68,3% of the cases (p=0,02) and RBI in 87,5% (p=0,000001) .Conclusion. Although both oncogenes (P53 and RBI) are deleted in OS population, it remains impossible to determine if this abnormality is a prognostic factor. These new and unreported findings in chromosome 21 of pediatric OS tumors, suggest that specific sequences mapping these chromosomal regions, would likely to play a role in the development of OS
Doutorado
Pediatria
Mestre em Saude da Criança e do Adolescente
Buck, Cecília Oliveira Barbosa 1975. "Estudo clínico-epidemiológico das osteocondrodisplasias de manifestação perinatal na América do Sul". [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308793.
Testo completoTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Osteocondrodisplasias (OCD) ou displasias esqueléticas são um grupo heterogêneo de doenças genéticas que afetam o crescimento. e o desenvolvimento do esqueleto e possuem alta morbimortalidade associada. Apesar dos avanços recentes no diagnóstico pré-natal e no conhecimento das bases moleculares das OCD, o seu diagnóstico ainda se baseia em anamnese, exame físico e radiografias de esqueleto. A prevalência habitualmente referida de 2,0/10.000, baseada em poucos estudos com populações pequenas, é subestimada. O objetivo deste estudo foi avaliar a epidemiologia das OCD na América do Sul (AS) utilizando uma grande população de mais de 1,5 milhões de nascimentos. Os casos de OCD foram selecionados dos arquivos do ECLAMC (um programa colaborativo de base hospitalar, caso-controle, para vigilância de defeitos congênitos) por dois códigos específicos (75640-OCD e 75650-Osteogenesis Imperfecta). Todos os casos nascidos entre 2000-2007 foram revisados e os diagnósticos finais foram escalonados em quatro níveis de evidência diagnóstica (NED), sendo o NED1 (padrão-ouro) casos com boas radiografias ou estudo molecular confirmando o diagnóstico. No período do estudo, 132 hospitais em 9 paises sul-americanos observaram 1.544.496 nascimentos. Todos os 51.827 controles nascidos no mesmo período foram utilizados para comparação. Excluídos 44 casos, a prevalência geral foi de 3,2/10.000 (IC95% 2,9-3,5) (492 casos em 1.544.496 nascimentos) e 33,6 (25,3-42,3) nos natimortos. Casos letais foram 50% (natimortos e óbito neonatal precoce). O diagnóstico foi referido como pré-natal na maioria dos casos (359-73%). Os grupos de OCD mais frequentes, segundo a classificação internacional, foram: G-1 (FGFR3) - 31%; G-25 (OI) - 23,5%; G-9 (CCP) - 4,5%; G-2 (Colágeno 2) - 4%; G-18 (Bent bones) - 4%. As prevalências das OCD mais comuns foram: OI - 0,74 (0,61-0,89); D. Tanatofórica - 0,47 (0,36-0,59); Acondroplasia - 0,44 (0,33-0,56); D. Campomélica - 0,10 (0,05-0,16). A taxa de mutação/gameta/geração para Acondroplasia foi 1,74 (1,25-2,25) x 10-5. Idade paterna, paridade e consanguinidade foram maiores nos casos que nos controles (31,2 anos X 28,9 anos; 2,6 X 2,3; 5,4% X 1,0%; P < 0,001). Idade materna elevada nos casos em relação aos controles (26,4 anos X 25,4 anos, P < 0,001) não foi confirmada por regressão logística considerando idades paterna e materna e paridade como fatores de risco para OCD (OR=1,63 para idade paterna > 39 anos; 0,79 para idade materna > 34 anos e 1,3 para paridade > 1). Peso e idade gestacional foram menores nos casos que nos controles (2498,1 g X 3198,6 g, P < 0,001), permanecendo a diferença para o peso após estratificação apenas para gestações de 31-35, 36-40 e 41-44 semanas (P<0,001, P<0,001 e P<0,05, respectivamente). A prevalência geral de 3,2/10.000 encontrada parece mais verossímil, sustentada por uma população numerosa e heterogênea, com grande diversidade étnica em sua composição, onde interrupções da gestação não são permitidas. Este estudo também observou uma alta taxa de diagnóstico pré-natal das OCD na AS e confirmou: a elevada morbi-mortalidade associada às OCD, a idade paterna elevada (especialmente nos casos de herança dominante) e altas taxas de consangüinidade nos casos de OCD (especialmente os de herança recessiva) e na população controle da AS
Abstract: Osteochondrodysplasias (OCD) are a heterogeneous group of genetic diseases that affect skeletal growth and development with a high infant morbid-mortality. Despite the great advances in prenatal diagnosis and knowledge of OCD molecular bases in the last twenty years, OCD diagnosis still relies upon anamnesis, clinical examination and skeletal X-rays. The currently accepted birth prevalence rate of OCD (2.0/10,000), based on few studies with small populations, is underestimated. This study aimed to assess OCD epidemiology in South America (SA) based on a large population of more than 1.5 million births. The OCD cases were ascertained from ECLAMC (a case-control, collaborative hospital-based program for birth defects surveillance) database through two specific codes (75640 for "generic" OCD and 75650 for Osteogenesis Imperfecta). All cases born from 2000 to 2007 were revised and final diagnoses ranked in four diagnostic evidence levels (DEL), being the DEL1 (gold-standard) those cases with good X-rays or DNA test supporting a certain diagnosis. During the 8-year period, 132 hospitals from nine South-American countries examined 1,544,496 births. For comparative analysis, all 51,827 controls born in the same period were used. After excluding 44 cases, overall OCD birth prevalence was 3.2 per 10,000 (95% CI 2.9-3.5) (492 cases per 1,544,496 births) and 33.6 (25.3-42.3) among stillbirths. Lethal cases (stillbirths plus early neonatal death) were 50%. Prenatal ultrasound diagnosis was referred in most cases (359 - 73%). The most frequent OCD groups, according to the international classification, were: G-1 (FGFR3) - 31%; G-25 (OI) - 23,5%; G-9 (SRP) - 4,5%; G-2 (Collagen 2) - 4% and G-18 (Bent bones) - 4%. The prevalence of the main OCD types were: OI - 0.74 (0.61-0.89); Thanatophoric D. - 0.47 (0.36-0.59); Achondroplasia - 0.44 (0.33-0.56); Campomelic D. - 0.10 (0.05-0.16). The mutation rate/gamete/generation for Achondroplasia was 1.74 (1.25-2.25) x 10-5. Paternal age, parity and consanguinity rate were significantly increased in cases compared to controls (31.2 years X 28.9 years; 2.6 X 2.3; 5.4% X 1.0%; P < 0.001). Increased maternal age in cases against controls' (26.4 years X 25.4 years, P < 0.001) was not confirmed by logistic regression including paternal age (OR=1.63 for paternal age > 39 years), parity (OR=1.3 for parity > 1) and maternal age (OR=0.79 for maternal age > 34 years) as risk factors for OCD. Birth weight and gestational age were lower in cases than in controls (2498.1 g X 3198.6 g, P < 0.001), and the difference for birth weight remained significant for gestational ages 31-35, 36-40 and 41-44 weeks after stratification (P < 0.001, P < 0.001 and P < 0.05, respectively). The OCD overall birth prevalence rate of 3.2 per 10,000 found seems more verisimilar, supported by a large and heterogeneous population with great ethnic diversity and without pregnancy terminations. This study also indicates a high rate of prenatal OCD diagnosis in SA and confirms: the high OCD-associated infant morbid-mortality, the increased paternal age (especially for cases with autosomal dominant inheritance) and the high parental consanguinity rates in both OCD cases (especially those with autosomal recessive inheritance) and in SA control population
Doutorado
Genetica Medica
Doutor em Ciências Médicas
Abdelhadi, Mohamed Mohamed. "Posttransplantation bone disease : the effect of immunosuppressive drugs on bone: clinical and experimental studies /". Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-384-8/.
Testo completoWedin, Rikard. "Metastatic bone disease /". Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-3829-6/.
Testo completoPhan, Tuan (Tony). "Functional characterisation of an osteoclast-derived osteoblastic factor (ODOF)". University of Western Australia. School of Surgery and Pathology, 2004. http://theses.library.uwa.edu.au/adt-WU2005.0028.
Testo completoChoi, Chung-yue. "Free radicals and bone marrow diseases a potential role of nitric oxide in graft-versus-host disease after bone marrow transplant /". Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23273367.
Testo completoPoulet, Blandine. "Characterising a model for non-invasive loading of the murine joint : initial studies into the interplay between mechanical and genetic factors in osteoarthritis". Thesis, Royal Veterinary College (University of London), 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.558982.
Testo completoSarrión, Pérez-Caballero Patricia. "Estudio genético de dos fenotipos óseos: osteocondromatosis múltiple y alta masa ósea". Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/127188.
Testo completoThere are two different studies that compose my thesis. The first one is a molecular analysis of multiple osteochondromas (MO) in Spanish and Latin American patients. MO is a genetically heterogeneous disease caused by mutations in two genes: EXT1 and EXT2. On sequencing all exons and flanking regions of those two genes in the samples of 39 unrelated patients, 37 pathogenic mutations were identified. Twenty-nine different mutations were found in the EXT1 gene, while 8 were found in EXT2. Eighteen out of the 37 mutations were novel. After the mutational analysis in Latin American patients the causative mutation in 18 of them has been identified. MLPA analysis has revealed mosaic mutations and it has been confirmed that such mutations can also lead to MO. Also a study of genotype-phenotype correlation in these patients was made. On the second one, my thesis addresses the molecular genetic study of high bone mass phenotype (HBM). Thirteen cases were found with this phenotype and the relevant exons of LRP5, described as HBM causative gene, and DKK1, that is LRP5 inhibitor, were sequenced. No mutations in the relevant exons of LRP5 were found. A rare missense change in DKK1 was found in one woman (p.Y74F). Fifty-five BMD SNPs were genotyped in the HBM cases to obtain risk scores for each individual. Z-scores were negatively correlated with these risk scores, with a single exception, which may be explained by a rare penetrant genetic variant. An expression analysis in primary osteoblasts from two HBM cases and five controls was carried out. It showed that IL6R, DLX3, TWIST1 and PPARG were negatively related to Z-score. One HBM case presented with high levels of RUNX2, while the other displayed very low SOX6. In conclusion, we provide evidence of heterogeneity and the additive effects of several genes for the HBM phenotype.
Putman, Melissa. "Cystic Fibrosis Related Bone Disease". Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17613728.
Testo completoHauser, Barbara. "Mechanism of bone loss in rheumatic diseases". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22823.
Testo completo蔡聰筎 e Chung-yue Choi. "Free radicals and bone marrow diseases: a potential role of nitric oxide in graft-versus-host disease after bonemarrow transplant". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2000. http://hub.hku.hk/bib/B31224222.
Testo completoGarazdiuk, O. I. "The role of bone disorders in chronic kidney disease and systemic connective tissue diseases progression, evaluation and therapeutic approaches". Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18586.
Testo completoDing, Hongliu. "Bone Health and Coronary Heart Disease in Postmenopausal Women with Breast Cancer Treated with Tamoxifen: A Dissertation". eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/404.
Testo completoLangford-Smith, Kia Jane. "Non-myeloablative bone marrow transplantation for Mucopolysaccharide diseases". Thesis, University of Manchester, 2012. https://www.research.manchester.ac.uk/portal/en/theses/nonmyeloablative-bone-marrow-transplantation-for-mucopolysaccharide-diseases(5d3fd9c5-01f2-42aa-81ed-a2ce6ef140fe).html.
Testo completoNixon, Matthew Frank. "Metabolic bone disease and arthroplasty loosening". Thesis, University of Leicester, 2009. http://hdl.handle.net/2381/8448.
Testo completoLucas, Gavin J. A. "Genetics of Paget's disease of bone". Thesis, University of Aberdeen, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430978.
Testo completoHocking, Lynne J. "Genetics of Paget's disease of bone". Thesis, University of Aberdeen, 2002. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU160239.
Testo completoLaketic-Ljubojevic, Ira. "Glutamate signalling in bone cells". Thesis, University of York, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311080.
Testo completoReid, Carol Anne. "Texture analysis of bone mineralisation surfaces". Thesis, University of Glasgow, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.287800.
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