Tesi: "Bone" – Grafiati

1

Toksvig-Larsen, Søren. "On bone cutting". Lund : University Dept. of Orthopedics, 1992. http://books.google.com/books?id=3JBsAAAAMAAJ.

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2

Clarke, Damian F. "Histological and radiographic variation in the parietal bone in a cadaveric population /". Online version, 1987. http://bibpurl.oclc.org/web/23173.

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3

Loftis, Dylan A. "Bone of my Bone". VCU Scholars Compass, 2019. https://scholarscompass.vcu.edu/etd/5896.

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Abstract (sommario):

This is a noticing and a return - a good old-fashioned call and response. An understanding and a becoming. At present, the noticing is on brokenness and the response on reparation. The work is filtered and guided through my background in traditional woodworking and furniture design. A lifetime love of comic books, storytelling, and illustration refuses silence, and it escapes in bursts as I work intuitively through design and material. A newly discovered love of writing finds meaning in that intuition. It’s impossible, even irresponsible, for me to notice and question the brokenness around me without questioning the brokenness within me. It’s cyclical. The noticing becomes self-examination; the response becomes self-discovery. By leaving my surroundings in a more secure, joyful state than I found them, I am assured of the following: They have been revived; given the opportunity to thrive once more in my absence. I am leaving better too.

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4

Åkesson, Kristina. "Fracture and biochemical markers of bone metabolism". Lund : University of Lund, Dept. of Orthopaedics, Malmö General Hospital, Sweden, 1995. http://books.google.com/books?id=Ib9qAAAAMAAJ.

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5

Öberg, Sven. "Bone healing after implantation of bone substitute materials : experimental studies in estrogen deficiency /". Umeå : Univ, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-138.

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6

Goodyear, Simon R. "Physicochemical methods for measuring the properties of bone and their application to mouse models of disease". Thesis, University of Aberdeen, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=133992.

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Abstract (sommario):

This thesis describes a toolbox of complementary techniques that together measure and mechanical properties of bone. Three-point bending is used to measure the mechanical properties of bone; micro computed tomography provides cortical geometry and parameters describing trabecular bone. The material properties, elastic modulus and density, are measured directly using ultrasound and Archimedes’ principle, while composition and bone chemistry are investigated by ashing and Raman microscopy. These methods are used to characterise bone from the naturally occurring Gunmetal mouse and the engineered neuronal nitric oxide synthase (nNOS) knockout mouse. Comparison was also made between femora and tibiae and cortical and trabecular bone from wild type mice. Gunmetal mice had inferior mechanical properties, but unaffected material and chemical properties. Cortical area but not second moment of area was also reduced. nNOS knockouts had superior bone mechanically, due to increased mineralisation and geometrical parameters. Femora and tibiae had different mechanical and material properties that were not linked to the size or shape of the bones. Cortical bone had characteristics of older bone compared to trabecular material, possibly due to the lower turnover rate. These results show the necessity for measuring material properties directly, rather than inferring them from mechanical and geometrical properties. The differences in femora and tibiae suggest testing only femur or tibia may result in the risk of missing important results. Application of this toolbox of methods provides a comprehensive description of bone’s overall fitness for purpose and an understanding of the origin of any defect or enhancement in its properties.

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7

Düppe, Henrik. "Bone mass in young adults determinants and fracture prediction /". Lund : Lund University, Dept. of Orthopaedics, 1997. http://catalog.hathitrust.org/api/volumes/oclc/39725785.html.

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8

Harden, Fiona J. "Digging into bone : investigative studies into silicate-substituted hydroxyapatite, collagen molecules and bone properties". Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=211423.

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Abstract (sommario):

Investigations into silicate-substituted hydroxyapatite (Si-HA) were performed. The aqueous precipitation method produced phase pure Si-HA with modi cations to the method causing impurities in the material. A novel study using Raman spectroscopy followed the behaviour of the silicate ions and provided a new interpretation regarding silicate substitution. The silicate ions created interactions with hydroxyl ions, initially, which reduced upon sintering of the material. As the silicate ions do not behave inde- pendently in the HA structure initially, suggests that these interactions may contribute to the bioactivity of Si-HA. Also industrial aspects of Si-HA were investigated regarding the silicate reagent (TEOS). A small di erence of 1% in the percentage concentration of TEOS was not negligible and caused a decrease in the amount of silicate substituted into HA. Di erent brands and grades of TEOS did produce Si-HA with similar structural properties. Therefore, a variety of brands and grades of TEOS can be used and thus the most cost e ective choice can be made. The rst analytical investigations into the molecular arrangement of fully mineralised osteoarthritic (OA) and osteoporotic (OP) bone were performed through small angle neutron scattering (SANS) studies. This study provided a description for the molecular arrangement of collagen molecules, along the lateral plane, regarding the molecular di- ameter and the packing of these molecules into the bril by the development of a model based on SANS theory. The collagen molecules behave like a 2-dimensional liquid-like system. Through the development of the model, the rst written solution for the struc- ture factor for a system of hard-disks was stated. This study provided an understanding into how collagen molecules are arranged in OA and OP bone. Also, compositional studies iterated possible di erences between the organic content of OA and OP bone. Thus the organic content of bone may play a role in the bone disorders.

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9

Wasserman, Nicholas David. "Physicochemical and compositional etiology of in vivo microcracks in human cortical bone tissue /". See Full Text at OhioLINK ETD Center (Requires Adobe Acrobat Reader for viewing), 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=toledo1092239102.

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Abstract (sommario):

Thesis (M.S.B.)--University of Toledo, 2004.
Typescript. "A thesis [submitted] as partial fulfillment of the requirements of the Master of Science degree in Bioengineering." Includes bibliographical references (leaves 94-99).

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10

Hirvinen, Laura J. M. "Influence of bone cements on bone screw interfaces in the third metacarpal and metatarsal bones of horses". Columbus, Ohio : Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1243434636.

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11

Söderlund, Veli. "Combined radiology and cytology in the diagnosis of bone lesions : a study of 494 patients /". Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-353-8/.

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12

Abdelhadi, Mohamed Mohamed. "Posttransplantation bone disease : the effect of immunosuppressive drugs on bone: clinical and experimental studies /". Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-384-8/.

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13

Cronhjort, Marika. "Influence of extrinsic factors on bone scintigraphy : an experimental and clinical study /". Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2747-2.

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14

Walsh, Jennifer. "Determinants of peak bone mass and bone size". Thesis, University of Sheffield, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.444828.

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15

Samizadeh, S. "Bone formation on calcium phosphate bone substitute materials". Thesis, University College London (University of London), 2010. http://discovery.ucl.ac.uk/19891/.

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Abstract (sommario):

A large number of bone substitute materials are available; for which some authors claim osteoconductivity and some osteoinductivity. In order to rank these materials an in vivo analysis was carried out. These materials were chosen based on their availability and claimed mode of action. Silicon substituted Hydroxyapatite (SiHA), Hydroxyapatite (HA), Resorbable Calcium Phosphate Silicon, Skelite [siliconstabilized tricalcium phosphate-based bone substitute], Pro Osteon 500R [coralline HA], BiIonic [Yttrium stabilized SiHA] and two non-calcium phosphate, Dimeneralised Bone Matrix (DBM) based biomaterials: Accell Connexus DBM putty and Grafton crunch DBM were implanted in sheep femoral condyle defects for 6 weeks. Implanted calcium phosphate (CaP) based biomaterials demonstrated superior bone formation in comparison with the DBM samples. Silicon within CaPs increased the rate of bone formation in vivo. Silicon substituted HA showed increased proliferation rate (P<0.05) of human marrow stromal cells compared to pure HA in vitro. Expression of osteoblastic marker genes RUNX2, Osterix and Osteopontin within the hMSCs indicated the differentiation of preosteoblasts into osteoblasts, and osteogenic development on both HA and SiHA. Expression of osteocalcin and bone sialoprotein genes on HA and SiHA samples indicated the activation of mineralisation process. Differentiation of hMSCs into osteoblasts in vitro suggested a role in promotion of osteoinduction by both HA and SiHA. Implantation of porous SiHA and HA in paraspinous muscle of sheep, exhibited new bone formation through osteoinduction. SiHA indicated significantly higher new bone formation (P<0.01) compared to HA. SiHA and HA biomaterials with higher strut porosity (30%) indicated greater bone formation (P<0.05). In conclusion, CaP based biomaterials demonstrate superior bone formation in comparison with DBM biomaterials. Silicon substitution within HA enhances the cellular activity of hMSCs. Osteoinduction was greatest on SiHA with higher strut porosity. This result is believed to be due to a combination of the effect of interconnected porosity and chemical composition of the bone substitute.

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16

Mahoney, Emilia. "Molecular Alterations in Bone Development and Bone Tumorigenesis". The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1243957525.

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17

Moulton, Renee. "Bone Garden". Thesis, California State University, Long Beach, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1528001.

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Abstract (sommario):

Bone Garden is a collection of poetry that inspects interpersonal communication and an often misguided sense of connection with others. Through investigations of memory, disaster, aging, and gender, the collection depicts a world in which many of us fruitlessly search for empathy and a sense of solidarity. Leading this investigation is a narrator whose frustrations with isolation often result in passive aggressive behavior or violence that furthers her separation from others. Bone Garden proposes solidarity as a salted plot and despair as the bitter fruit harvested by those who believe in it.

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18

Chen, Jinbiao Prince of Wales Clinical School UNSW. "In vitro and in vivo bone formation - assessment and application". Awarded by:University of New South Wales. Prince of Wales Clinical School, 2006. http://handle.unsw.edu.au/1959.4/24922.

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Background: Bone-grafting materials are required in orthopaedic surgery to treat bone defects. Bone formation assessment is required for the development of new strategies and approaches and for quality assurance and quality control of currently available materials. Approaches to the assessment of bone formation are yet to be systematically established, quantified and standardized. Aims: the overall aim of this study was to establish a set of comprehensive quantitative approaches for the assessment of bone formation and to evaluate the role of osteoblastic cells, growth factors, and scaffolds on this process. Materials & methods: both in vitro and in vivo parameters for osteoblast phenotype and bone formation were tested in osteosarcoma cell lines, Saos-2 and U2OS cells, mesenchymal cell line, C2C12 cells, primary adipose derived stromal cells (ADSCs), platelet rich plasma (PRP), and morselized bone grafts. The in vitro parameters used were measurement of alkaline phosphatase (ALP) activity, detection of bone nodules and biomineralization, and quantification of immunocytochemistry and conventional RT-PCR of osteoblast genotyping. In vivo parameters involved ectopic bone formation in nude mice and nude rats and a tibial defect model in nude rats. Histomorphometric and quantitative immunohistochemical analyses were also performed. Results: The in vitro characterization and ectopic bone formation capabiltity of Saos-2 and U2OS cells have been established. Saos-2 cell line, which presents many osteoblast genotype and phenotype, is a stable positive control for both in vitro and in vivo bone formation assessments. The measurement of ALP activity in both solid and liquid phases has been standardized. Both the genotype and phenotype of osteoblast lineage cells has been quantitatively assessed during the capability testing of ADSCs and PRP. Quantitative assessment of new bone formation and related protein markers in vivo has been successfully established through the testing of the biological properties of gamma irradiated morselized bone grafts. Conclusion: A comprehensive knowledge of the assessment of bone regeneration and formation in vitro and in vivo has been integrated and developed through years of study. A whole set of in vitro and in vivo approaches for the assessment of bone formation has been modified and standardized to best suit the different clinical applications. This thesis provides an outline of both in vitro and in vivo bone formation assessment and their clinical applications.

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19

O'Keeffe, Darin. "Denoising of Carpal Bones for Computerised Assessment of Bone Age". Thesis, University of Canterbury. Department of Electrical and Computer Engineering, 2010. http://hdl.handle.net/10092/4552.

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Abstract (sommario):

Bone age assessment is a method of assigning a level of biological maturity to a child. It is usually performed either by comparing an x-ray of a child's left hand and wrist with an atlas of known bones, or by analysing specific features of bones such as ratios of width to height, or the degree of overlap with other bones. Both methods of assessment are labour intensive and prone to both inter- and intra-observer variability. This is motivation for developing a computerised method of bone age assessment. The majority of research and development on computerised bone age assessment has focussed on analysing the bones of the hand. The wrist bones, especially the carpal bones, have received far less attention and have only been analysed in young children in which there is clear separation of the bones. An argument is presented that the evidence for excluding the carpal bones from computerised bone age assessment is weak and that research is required to identify the role of carpal bones in the computerised assessment of bone age for children over eight years of age. Computerised analysis of the carpal bones in older children is a difficult computer vision problem plagued by radiographic noise, poor image contrast, and especially poor definition of bone contours. Traditional image processing methods such as region growing fail and even the very successful Canny linear edge detector can only find the simplest of bone edges in these images. The field of partial differential equation-based image processing provides some possible solutions to this problem, such as the use of active contour models to impose constraints upon the contour continuity. However, many of these methods require regularisation to achieve unique and stable solutions. An important part of this regularisation is image denoising. Image denoising was approached through development of a noise model for the Kodak computed radiography system, estimation of noise parameters using a robust estimator of noise per pixel intensity bin, and incorporation of the noise model into a denoising method based on oriented Laplacians. The results for this approach only showed a marginal improvement when using the signal-dependent noise model, although this likely reflects how the noise characteristics were incorporated into the anisotropic diffusion method, rather than the principle of this approach. Even without the signal-dependent noise term the oriented Laplacians denoising of the hand-wrist radiographs was very effective at removing noise and preserving edges.

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20

Barragan-Adjemian, Maria del Cielo Bonewald Lynda F. "Mechanisms of mineralization in bone". Diss., UMK access, 2006.

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Abstract (sommario):

Thesis (Ph. D.)--School of Dentistry. University of Missouri--Kansas City, 2006.
"A dissertation in oral biology and cell biology and biophysics." Advisor: Lynda F. Bonewald. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed Nov. 12, 2007. Includes bibliographical references (leaves 121-139). Online version of the print edition.

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21

Mikkelsen, Christina. "Rehabilitation following bone-patellar tendon-bone graft ACL reconstruction /". Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-913-0/.

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22

黃美娟 e May-kuen Alice Wong. "Bone induction of demineralized intramembranous and endochondral bone matrices". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B3197305X.

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23

Wong, May-kuen Alice. "Bone induction of demineralized intramembranous and endochondral bone matrices". View the Table of Contents & Abstract, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21872752.

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24

Hasan, Jahid. "Decellularisation and characterisation of porcine bone-medial meniscus-bone". Thesis, University of Leeds, 2014. http://etheses.whiterose.ac.uk/7661/.

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Abstract (sommario):

The meniscus in the knee functions to absorb shock and transmit load within the joint. Problems arise when the meniscus is injured or damaged as the meniscus’ healing potential is limited by the limited vascular supply extending only ~20% of the way through the mature meniscus. Current treatment options are only effective at abating further degeneration and osteoarthritis due to altered joint mechanics. Replacement of the meniscus has the potential to prevent the onset of osteoarthritis by restoring native joint mechanics. Here we aim to develop a decellularisation protocol for porcine medial meniscus with added bone blocks for easy fixation for use as a meniscal replacement. Menisci were decellularised using a low sodium dodecyl sulphate (SDS) method including freeze-thaw cycles, hypertonic, hypotonic and nuclease wash steps, as well as mechanical removal of cellular material. Decellularised menisci were then characterised histologically, immunohistochemically, biochemically and biomechanically for successful decellularisation and compared to native meniscus. Histology revealed the absence of whole cells and nuclei from meniscus and bone, while quantification of DNA revealed ~96% and ~91% removal of DNA from meniscus and bone, respectively. Immunohistochemical analysis showed retention of major structural collagens I, II and II; however there was complete removal of collagen IV and some loss of collagen VI. Hydroxyproline assay showed retention of collagen and the collagen content of native meniscus was 802.90 (± 52.95, 95% CL) mg.g-1 dry weight and for decellularised meniscus was 935.35 (± 18.03, 95% CL) mg.g-1 dry weight, however there was a complete loss of GAGs from the decellularised matrices as revealed by Safranin O staining and quantified using dimethyl methylene blue assay (23.49 ± 8.63 μg.mg-1 vs. 0.30 ± 0.47 μg.mg-1, 95% C.I.). There was also a 51% reduction in calcium content of the decellularised bone blocks when compared to native bone blocks. Material properties of meniscus were obtained using uniaxial tensile and indentation testing with no significant differences observed between native and decellularised groups under tension although greater deformation was seen for decellularised samples under compression. Unconfined compression of bone however revealed a significant decrease in the compressive modulus and strength of decellularised bone blocks. Differential scanning calorimetry revealed no significant differences in thermal stability between native and decellularised meniscus except for in the attachment region where collagen was mechanically manipulated prior to decellularisation. Magnetic resonance imaging (MRI) also revealed no gross differences between native and decellularised bone and meniscus. Extract and contact cytotoxicity assays were used to determine biocompatibility of decellularised bone-meniscus-bone and residual SDS content determined using radio-labelled 14C SDS. There was 0.289 μg.mg-1 of residual SDS in decellularised bone-meniscus-bone and assays showed no cytotoxicity to 3T3 and BHK cells. The immunogenic galactose-α-1,3-galactose epitope could not be detected in decellularised meniscus by immunohistochemistry. In conclusion, a protocol for the successful decellularisation of porcine bone-medial meniscus-bone has been developed which retains the structure and tensile properties of native meniscus and is non-cytotoxic. Further investigation is required to determine whether loss of mechanical strength in the bone will prevent effective fixation in vivo.

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25

Porter, Ryan Michael. "Examination of Glucocorticoid Treatment on Bone Marrow Stroma: Implications for Bone Disease and Applied Bone Regeneration". Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/36365.

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Long-term exposure to pharmacological doses of glucocorticoids has been associated with the development of osteopenia and avascular necrosis. Bone loss may be partially attributed to a steroid-induced decrease in the osteoblastic differentiation of multipotent progenitor cells found in the bone marrow. In order to determine if there is a change in the osteogenic potential of the bone marrow stroma following glucocorticoid treatment, Sprague-Dawley rats were administered methylprednisolone for up to six weeks, then sacrificed at 0, 2, 4, or 6 weeks during treatment or 4 weeks after cessation of treatment. Femurs were collected and analyzed for evidence of steroid-induced osteopenia and bone marrow adipogenesis. Although glucocorticoid treatment did inhibit bone growth, differences in ultimate shear stress and mineral content were not detected. The volume of marrow fat increased with increasing duration of treatment, but returned to near control levels after cessation of treatment. Marrow stromal cells were isolated from tibias, cultured in the presence of osteogenic supplements, and analyzed for their capacity to differentiate into osteoblast-like cells in vitro. Glucocorticoid treatment diminished the absolute number of isolated stromal cells, but did not inhibit the relative levels of bone-like mineral deposition or osteocalcin expression and secretion. Although pharmacological glucocorticoid levels induce bone loss in vivo, physiologically equivalent concentrations have been shown to enhance the formation of bone-like tissue in vitro. However, glucocorticoids have also been reported to inhibit proliferation and type I collagen synthesis in marrow stromal cell cultures. In order to assess the effects of intermittent dexamethasone treatment on the progression of osteogenesis in rat marrow stromal cell culture, this synthetic glucocorticoid was removed from the culture medium after a variable period of initial supplementation. Cell layers were analyzed for total cell number, collagen synthesis, phenotypic marker expression, and matrix mineralization. Prolonged supplementation with dexamethasone decreased proliferation, but did not significantly affect collagen synthesis. Furthermore, increased treatment duration was found to increase bone sialoprotein expression and mineral deposition. The duration of glucocorticoid treatment may be a key factor for controlling the extent of differentiation in vitro.
Master of Science

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26

Tervo, Taru. "Physical activity, bone gain and sustainment of peak bone mass". Doctoral thesis, Umeå : Umeå University, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-26928.

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27

Li, Jian. "Spontaneous correction of fracture deformity : a study in the rat /". Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-119-9/.

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28

Wejheden, Carolina. "Studies on gender-specific disruption of bone tissue homeostasis by dioxins". Stockholm : Institutet of Environmental Medicine, Karolinska Institutet, 2010. http://diss.kib.ki.se/2010/978-91-7409-728-3/.

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29

Brismar, Torkel. "Assessment of skeletal structure by MR relaxometry /". Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3343-X/.

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30

Suliman, Isam Ahmed. "Neuromuscular effects related to hind limb disuse : experimental studies in the rat /". Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3786-9/.

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31

Cho, Helen. "Age-associated bone loss in an imperial roman population : an histological analysis of inter-skeletal and intra-skeletal variability /". free to MU campus, to others for purchase, 2002. http://wwwlib.umi.com/cr/mo/fullcit?p3052164.

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32

Powell, Diane Elizabeth. "The effect of bone matrix extract on bone cell activity". Thesis, University of Chester, 2006. http://hdl.handle.net/10034/76642.

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Abstract (sommario):

Bone remodelling is a complex process, which involves the coupling of bone formation to completed foci of bone resorption, the balance between these 2 processes determines if bone is lost or gained at a particular site. During bone resorption osteoclasts release growth factors sequestered in bone matrix, which are thought to initiate new bone formation. On the other hand, osteoblasts can regulate osteoclast activity through the expression of the counter-acting cytokines, RANKL and OPG. The aim of this project was to determine if factors released during bone resorption impact on the RANKL/OPG system or on osteoclasts directly to regulate bone remodelling. OPG secretion was characterized in a number of osteoblast-like cells and the osteosarcoma cell line MG-63 was chosen as a model for osteoblastic cell behaviour in vitro. EDTA bone extracts prepared from normal human cortical bone powder were used to treat MG-63 cells in vitro. The response to the extract was dependent on the purification procedure used. OPG production was inhibited by partially purified extracts prepared using hydrophobic interaction chromatography, C18 SPE. In comparison extracts prepared using size exclusion centrifugal filters stimulated OPG secretion in confluent MG-63 cells. Therefore bone matrix constituents were able to influence osteoclast activity directly and indirectly through the osteoblastic cells to produce the same response. The simplest mechanism for this co-ordinated response would be the presence of one factor in the extract that is able to influence both osteoblasts and osteoclasts. The identity of the factor responsible for the opposing effects seen in the bone matrix extracts is at the moment unknown. The work presented in this thesis clearly demonstrated that unknown growth factors present in bone matrix influence bone remodelling.

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33

Bannerman, Alistair L. "Imaging the development of a bone-to-bone ligament construct". Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6425/.

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Ligament injuries are commonplace, with poor native healing leaving injury sites exposed to instability and further damage. A number of surgical methods have been established for reconstruction using a range of materials, but these have a high failure rate and a number of undesirable side-effects. Much recent work has been focused on the development of tissue engineered ligament grafts. One of the major challenges for this is the formation of an effective ligament-bone interface. In native tissue a multi-phase interface enables smooth transfer of forces between the mechanically mismatched bone and ligament tissue, however this has proved hard to replicate. Previous work has developed a bone-bone ligament construct model intended to emulate the native interface through formation of a mineralised region by soluble cement anchors. Development and optimisation of the model has seen an increasing mechanical strength, but the mechanisms involved are poorly understood. This study investigates the development of the ligament construct through the use of multiple complimentary imaging techniques to provide information on the biological, chemical, and topological development of the construct as it forms from initially homogeneous and separate materials to a complex non-homogeneous system.

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34

Hussein, Hayam. "Cathepsin K Inhibition In Bone And Bone Marrow In Horses". The Ohio State University, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=osu1449218489.

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35

LACAVA, GIOVANNA. "A Comprehensive Study on Homeostatic Bone and Bone Marrow Mediators". Doctoral thesis, Università degli Studi di Camerino, 2019. http://hdl.handle.net/11581/428952.

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Abstract (sommario):

Bone marrow is an extremely complex tissue, whose function is to accommodate the hematopoietic and the bone stem/progenitor cells. In particular, the bone marrow stromal microenvironment consists of several different types of cells, including bone lining osteoblasts, endothelial cells, reticular adventitial cells, neuronal cells and mesenchymal stem cells. Here, this large number of different populations coexist and exchange several signals in order to preserve bone marrow homeostasis. Accordingly, it is necessary to highlight that changes in the bone marrow steady-state may lead to localized and/or systemic diseases. The characteristics and the properties in the bone and bone marrow environment have been well elucidate for a number of factors, while less is known about other molecules, although they play critical functions within these tissues. Among them, the p62 multidomain protein has been associated with the osteoclastogenic processes, but not well-defined information is, so far, present in the literature regarding its function in the fine-tuned processes underling the bone and bone marrow metabolic features. Recently, we demonstrated that p62 regulates osteoblasts differentiation and that p62 deficiency inhibits the bone turnover rate. Consistently, our studies aimed at analyzing the bone marrow features of p62 KO mice. We showed that a significant adipocyte infiltration, particularly evident during the aging. This observation, together with the finding of a decreased osteolineage cell pools, impaired CXCL12/CXCR4 signaling and hemosiderin accumulation, demonstrated that p62 deficiency is able to disrupt bone marrow niche homeostasis overall in aged mice. The other molecule here studied is the soluble cytokine IFN-γ. By means of administration of a plasmid coding for IFN-γ (pINF-γ) both in ovariectomized (osteopenic) and in the sham-operated mice, we demonstrated that pINF-γ injections induced pathologic bone and bone marrow alterations, characterized by cortical and trabecular bone loss, increased proinflammatory cytokine release and impaired mesenchymal stem cells (MSCs) osteoblastogenic differentiation. In addition, the reduction of CXCL12+ cell number and the observation of hypercellular areas in the bone marrow of sham-operated and ovariectomized mice administered with pINF-γ, further suggest that IFN-γ is an important mediator of bone catabolism. During my PhD course we also investigated the therapeutic effects of a new hyaluronic acid-based hydrogel in a mouse model of knee osteoarthritis. Our results demonstrated that hydrogel administration allowed for the controlled and sustained release of hyaluronic acid, prolonging so the exposure of osteoarthritic knees to this biopolymer and promoting cartilage and subchondral bone regeneration. We also proved that hyaluronic acid-bearing hydrogels were able to counteract osteoarthritis by decreasing on the one hand the expression of pro-inflammatory mediators, while on the other hand by inducing MSCs differentiation and maturation into chondroblasts.

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36

Nyquist, Fredrik. "The influence of alcohol on bone metabolism and fracture healing". Lund : Lund University, Dept. of Orthopaedics, Malmö University Hospital, 1998. http://catalog.hathitrust.org/api/volumes/oclc/39792795.html.

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37

Hellström, Hans-Olov. "Bone and Aluminium". Doctoral thesis, Uppsala University, Department of Surgical Sciences, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8181.

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Osteoporosis is a major health care problem, by reason of its devastating consequences, in particular hip fractures. Worldwide it has been estimated that the incidence of hip fracture will increase to more than 6 million per year by 2050 compared to 1.7 million per year in 1990. Osteoporosis can be caused by various factors namely, genetic, lifestyle and environmental factors, and since the rising incidence of its consequences is not fully explained by the growing age of the population, there is an urgent need to identify individual causal factors of this condition.

The present research has focused on aluminium, one potential environmental factor of importance for bone disease, and its possible relation to osteoporosis, since it is known to cause osteoporosis-like bone disease and has been associated with induction of progressive central nervous system diseases.

Aluminium is the third most common element in the earth’s crust and the most abundant metal (8%). It is widely utilized industrially and it is also naturally present in many foods. Although aluminium is ubiquitous in the human environment, evolution has not given it an essential biological function.

The aluminium content of bone was measured by inductively coupled mass spectrometry in a large group of patients suffering from hip fractures, high energy fractures and osteoarthrosis. An exponential increase in aluminium content of bone with age was found (p=0.0004). However, no significant association of aluminium in bone with occurrence of hip fracture or dementia could be found, and no indirect evidence was obtained, e.g. through bone mineral density or biomechanical properties, that aluminium is involved in the pathogenesis of osteoporosis. Although we accumulate aluminium in bone throughout our lives, and there are experimental suggestions that aluminium induces premature cell death, the body content of this metal does not seem to influence the overall mortality risk.

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38

Wedin, Rikard. "Metastatic bone disease /". Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-3829-6/.

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39

Hellström, Hans-Olov. "Bone and aluminium /". Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8181.

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40

MacBeath, Alan. "Ultrasonic bone cutting". Thesis, University of Glasgow, 2006. http://theses.gla.ac.uk/2220/.

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This thesis reports on the design of ultrasonic bone cutting blades and the effect of various cutting parameters such as applied load, blade tip vibration velocity and frequency on cutting speed and temperature, two performance indicators used by orthopaedic clinicians. A range of high gain blades was developed to investigate the correlation between the frequency response predicted by finite element analysis (FEA) and the frequency response measured using an experimental model analysis (EMA) technique. It has been found that FEA frequency predictions are within 1.5% of measured frequencies. FEA has also been used to develop two novel ultrasonic cutting models which allow the effect of blade progression on cutting performance to be investigated. The models have been used to predict the relationship between applied load and cutting speed in single layer and multi-layer materials, and have shown that cutting speed decreases as cortical layer thickness increases, a trend also found from cutting experiments. Ongoing developments to predict temperature from both cutting models have produced a preliminary result which locates regions of maximum cutting temperature. The result influenced the design of blades with modified tip geometries that have been used to reduce cutting temperature. Ultrasonic cutting experiments were performed on bovine bone, two bone substitute materials and various grades of wood. Deep incisions were made for a range of applied loads and cutting speeds to investigate the effect of various cutting parameters on cutting temperature. Ultrasonic cutting has been successfully applied to perform deep incisions in bone whilst maintaining substrate temperature to within critical levels. Two innovative modelling techniques have been used to simulate ultrasonic cutting and demonstrate their potential for revolutionising blade design, and surgical trials.

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41

Mawhinney, Ian Nicholas. "Bone and ultrasound". Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335942.

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42

Rice, Judith. "Bone biomaterial interactions". Thesis, University of Liverpool, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366672.

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43

Dyantyi, Mbongisi Orlean. "A bone fragment". Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/d1015677.

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This novella presents three characters, each occupying a different sphere of reality. One is a ‘living dead’ who is forced to return to the land of the living for his continued existence. The other is a young woman who, having lost the will to live, must find a purpose if she is to continue living. The third is a young man who dwells more in the inner than the external world. Their lives intersect through the scripture known as ‘a fragment of a bone.’

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44

Lapin, Blake. "Durability of Bone". Scholarship @ Claremont, 2019. https://scholarship.claremont.edu/cmc_theses/2160.

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Blake Lapin's senior thesis, Durability of Bone, is a five-part collection of poems written, edited, and compiled under the mentorship of Henri Cole. Themes include loss, love, travel, disability, and home.

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45

Hobson, Lauren Verdell. "Follow the Bone". PDXScholar, 2019. https://pdxscholar.library.pdx.edu/open_access_etds/4993.

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Follow the Bone is the author's exploration of what it means to live truthfully and authentically in an increasingly digitized and artificial world, through the author's growth as a woman and hunter in her native Oregon. With raw honesty, Lauren takes the reader through the years she spent post-college learning how to live outside of the structure of academia. As she struggles to balance the demands of a corporate job, a long-term relationship, and the pressure of social media, she brings the reader back to the places and the pursuit that save her. The reader is invited into a world of forests, mountains, trees and wild animals, where the author navigates the reality of being a meat eater with nuance and care. With vivid imagery and a gentle attention to detail, it becomes clear how deeply connected the author is to the world around her through the land, the people she loves and the animals she admires. Her growth as a person and her dedication to living a life of meaning is captured and reflected through her rich prose while she meditates on the outdoor experiences that defined her early twenties. Her stories become an entry point into an existence that lives and breathes close to the land and illustrate how participating fully in a habitat can change our understanding of what it means to be human, while also allowing for the necessity of living in a city. This book provides a narrative that doesn't feature a helpless woman finding herself in the outdoors through various mishaps and mistakes. Rather, it reflects how we all create our conception of self from what we inherit, and how women claiming their identity through the natural world can be a powerful force.

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46

Carlfjord, Caspar, e Elin Hedström. "Long-term Evaluation of Bone Augmentation Procedures with Autogenous Bone or Bone Substitutes in Association with Implant Treatment". Thesis, Malmö högskola, Odontologiska fakulteten (OD), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-19845.

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Syfte. Syftet med denna systematiska litteraturöversikt var att undersöka det vetenskapliga underlaget avseende långsiktig stabilitet hos olika typer av benersättningsmaterial i kombination med implantatinstallation.Material och metod. En elektronisk sökning gjordes med hjälp av PubMed och Web of Science. Block med sökord konstruerades och skrevs in i sökmotorerna för att hitta studier med implantatbehandling i kombination med benaugmentation, med en radiologisk uppföljning efter minst 2 år. Funna artiklar granskades i förhållande till förutbestämda inklusions- och exklusionskriterier. Data från inkluderade studier registrerades. Risken för bias i de inkluderade studierna bedömdes enligt modifierade protokoll.Resultat. Den elektroniska sökningen resulterade i 1183 studier, varav 14 studier med antingen autogent, allogent, xenogent eller alloplastiskt benersättningsmaterial inkluderades i denna litteraturöversikt. Resultatet från studierna visade en stor skillnad i både tekniker och material.Slutsats. Den generella slutsatsen i denna studie är att den marginella benförlusten vid dentala implantat som placerats i augmenterat ben inte överstiger 1 mm inom två år. En mer exakt slutsats om den marginella bennivåns stabilitet kunde inte dras på grund av de stora skillnaderna mellan de inkluderade studierna. Det finns ett behov av fler högkvalitativa studier med långtidsuppföljning som undersöker och jämför den marginella bennivåns stabilitet för olika benersättningsmaterial.
Aim. The purpose of this systematic review was to investigate the literature available regarding long-term stability of different bone augmentation materials in combination with dental implant treatment.Material and methods. An electronic search was done using PubMed and Web of Science. Blocks with keywords were constructed and inserted into the search engines to find studies involving implant treatment in combination with bone augmentation, with a radiographic follow-up of at least 2 years. Found articles were reviewed in relation to predetermined inclusion- and exclusion criteria. Data from included studies was extracted. Included studies were assessed of risk of bias according to modified protocols. Results. The electronic search yielded 1183 studies. 14 studies using either autogenous, allogeneic, xenogeneic or alloplastic augmentation materials was included in this review. The results from the data extraction process showed a wide variation in both materials and techniques used.Conclusion. The general conclusion drawn from this study is that marginal bone loss around dental implants placed in augmented bone does not exceed 1 mm within two years post-operatively. A more precise conclusion regarding marginal bone level stability could not be drawn due to the heterogeneity of the included studies. There is a need for additional high-quality studies with long-term follow-up, investigating and comparing marginal bone level stability for different bone augmentation materials.

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47

Kilbarger, Amy K. "The effect of iron overload on osteoblast function in cell culture". Greensboro, N.C. : University of North Carolina at Greensboro, 2007. http://libres.uncg.edu/ir/listing.aspx?styp=ti&id=146.

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Thesis (M.S.)--University of North Carolina at Greensboro, 2007.
Title from PDF t.p. (viewed Feb. 29, 2008). Directed by Deborah Kipp; submitted to the School of Human Environmental Sciences. Embargoed until Dec. 20, 2008. Includes bibliographical references (p. 47-56).

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48

Ransjö, Maria. "Regulation of bone resorption by the adenylate cyclase-cyclic AMP system a biochemical study on mouse calvarial bones and isolated bone cells /". Umeå, Sweden : University of Umeå, 1988. http://catalog.hathitrust.org/api/volumes/oclc/18171035.html.

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49

Ma, Li. "The influence of nicotine on angiogenesis and osteogenesis in bone regeneration". Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41508440.

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50

Voide, Romain. "Functional phenotyping of bone : a hierarchical assessment of bone failure characteristics". Zürich : ETH, 2007. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17524.

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Tesi sul tema "Bone"

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