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Tesi sul tema "Bone Physiology"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 11 marzo 2023

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1

Shum, Laura C. "Mitochondrial Metabolism in Bone Physiology and Pathology." Thesis, University of Rochester, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10792056.

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<p> Worldwide, 1 in 3 women and 1 in 5 men over age 50 will experience fractures due to a decline in bone quality. Elucidating the mechanisms for declining bone quality can lead to better therapeutics. A vital, yet overlooked aspect of bone health is the role of mitochondrial metabolism in both bone physiology and pathology. We have found that the ability of stem cells to differentiate into bone forming osteoblasts is sensitive to mitochondrial dysfunction, and therefore preserving mitochondrial function is essential to maintaining bone quality. In human patient samples, we found that osteogen

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2

Shah, Mittal. "The role of 5' adenosine monophosphate-activated protein kinase (AMPK) in bone physiology." Thesis, Royal Veterinary College (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559073.

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3

Blackwell, Penelope J. "Bone turnover in hyperprolactinaemic states." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366417.

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4

Charras, Guillaume. "Cellular mechano-transduction in bone." Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269783.

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5

Wakley, Glenn Keith. "Space flight and bone." Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246296.

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6

Bannerman, Alistair L. "Imaging the development of a bone-to-bone ligament construct." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6425/.

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Abstract (sommario):

Ligament injuries are commonplace, with poor native healing leaving injury sites exposed to instability and further damage. A number of surgical methods have been established for reconstruction using a range of materials, but these have a high failure rate and a number of undesirable side-effects. Much recent work has been focused on the development of tissue engineered ligament grafts. One of the major challenges for this is the formation of an effective ligament-bone interface. In native tissue a multi-phase interface enables smooth transfer of forces between the mechanically mismatched bone

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7

New, Susan A. "An epidemiological investigation into the influence of nutritional factors on bone mineral density and bone metabolism." Thesis, University of Aberdeen, 1995. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602275.

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A food frequency questionnaire (FFQ) was developed for a study investigating dietary influences on bone mineral density (BMD) and bone metabolism (BM). The percentage contribution of food groups to nutrients of interest were identified from 20 7d weighed records (WR) and incorporated to form a 98 food item FFQ. The FFQ was validated against a further 20 7d WR, and the short (6 weeks) and long-term (1 year) reproducibility tested. Mean nutrient intakes by 7d WR and FFQ, and initial and repeat FFQ were similar and cross-classification showed few women to be grossly misclassified. Information was

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8

PAOLETTI, Nicola. "Formal Computational Modelling of Bone Physiology and Disease Processes." Doctoral thesis, Università degli Studi di Camerino, 2014. http://hdl.handle.net/11581/401835.

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This thesis addresses the definition and the application of formal techniques in the field of Computational Systems Biology, with particular focus on bone remodelling (BR), the cellular process of bone renewal, and on the analysis and control of disease processes. Firstly, we study the multiscale and spatial mechanisms that connects disruptions at the molecular signalling level, to osteoporosis and other diseases characterized by low bone mass and structural weakening at the tissue level. We define a modelling framework based on a formal specification language which extends the Shape Calculus,

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9

Breckon, Anke. "An investigation of the morphological and mechanical properties of cancellous bone in rheumatoid arthritis and osteoarthritis of the hip." Master's thesis, University of Cape Town, 1993. http://hdl.handle.net/11427/26328.

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10

Oreffo, R. O. C. "Vitamin A and bone." Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376950.

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11

Yu, Vionnie Wing Chi. "Factor inhibiting ATF4-mediated transcription is a novel leucine zipper transcriptional repressor that regulates bone mass." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103311.

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Abstract (sommario):

Skeletal development is a complex event that requires a delicate balance between bone formation and bone resorption. Multiple transcription factors expressed in the bone-forming cells, osteoblasts, play crucial roles during the process of bone formation. Among them, ATF4 (Activating Transcription Factor 4) is a basic domain-leucine zipper transcriptional activator that is responsible for osteoblast differentiation, osteoblast-specific genes expression, synthesis of type I collagen, and osteoclast differentiation. Mice deficient for ATF4 are runted and exhibit severe skeletal dysplasia. Our lab

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12

Romero, Rodney Gray. "The histology of bone and its piezoelectric characteristics." Thesis, Kingston University, 1986. http://eprints.kingston.ac.uk/20508/.

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An investigation into the effects of micro electric currents on the material of bone is presented along with a review of the ideas and concepts associated with bone’s response to load and the alleged piezoelectric phenomena. A comparison is made between the structure of bone, its strength and stress generated potential. Evidence is forwarded to show that micro currents may influence the behaviour of bone material and it is demonstrated that these effects may be understood through reference to the limiting molar conductivities of the ions in the material and the solutions used.

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13

Ellis, Tiffany A. "Comparison of bone density in female vollyball players and age-matched non-athletes." Virtual Press, 2005. http://www.oregonpdf.org.

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14

Allsopp, Richard Patrick. "The role of the vascular endothelium in bone formation." Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386827.

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15

Orr, J. F. "Experimental measurement of stresses in bone and joint replacements." Thesis, Queen's University Belfast, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373559.

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16

Dobson, Katharine Rebecca. "Studies into the effects of androgens on bone formation." Thesis, University of Sheffield, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301007.

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17

Avenell, Alison. "Nutritional influences on bone metabolism : three studies in postmenopausal women." Thesis, University of Aberdeen, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361777.

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Abstract (sommario):

Eleven postmenopausal women made weighed food intakes and urine collections for one week, to determine influences on urinary calcium and deoxypyridinoline excretion. Urinary calcium was influenced by both dietary calcium and dietary fibre. Urinary deoxypyridinoline was increased in women consuming more dietary fibre. The influence of ketosis was examined in five postmenopausal women, who increased urinary hydrogen ion excretion, but had no consistent changes in urinary calcium or deoxypyridinoline excretion. Forty-six postmenopausal women, with body mass index greater than 27kg/m<sup>2</sup>,

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18

Campbell, Craig. "Bone health in children with cerebral palsy." Thesis, University of Ottawa (Canada), 2006. http://hdl.handle.net/10393/27231.

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Abstract (sommario):

Background. Children with cerebral palsy (CP) encounter a number of orthopedic complications as a result of abnormalities in motor function. One of the most significant complications is fragility fractures, occurring in up to 23% of children in prior reports. Despite a growing literature on how to best interpret bone densitometry in children, little research has determined optimal utilization of dual x-ray absorptiometry (DXA) in children with CP in order to characterize the patients' bone health status. This study outlines the use of the mechanostat theory of bone physiology to classify osteo

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19

Gambari, Laura <1985&gt. "Hydrogen Sulfide (H2S) Based Therapeutics for Bone Diseases: Translating Physiology to Treatments." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7535/1/gambari_laura_tesi.pdf.

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Abstract (sommario):

Much progress has been made in the past decade in elucidating the physiological, pathophysiological and pharmacological role of Hydrogen Sulphide (H2S). Recently a function of H2S virtually in every tissue of the human organism has emerged. However, the H2S-mediated regulation of bone homeostasis has been scarcely investigated. Despite a recent increased interest in the field, many fundamental issues remain indeterminate. The main objective of this study was to increase the basic knowledge on the role of H2S in bone through in vitro and in vivo studies and develop novel therapeutic strategies

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20

Gambari, Laura <1985&gt. "Hydrogen Sulfide (H2S) Based Therapeutics for Bone Diseases: Translating Physiology to Treatments." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7535/.

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Abstract (sommario):

Much progress has been made in the past decade in elucidating the physiological, pathophysiological and pharmacological role of Hydrogen Sulphide (H2S). Recently a function of H2S virtually in every tissue of the human organism has emerged. However, the H2S-mediated regulation of bone homeostasis has been scarcely investigated. Despite a recent increased interest in the field, many fundamental issues remain indeterminate. The main objective of this study was to increase the basic knowledge on the role of H2S in bone through in vitro and in vivo studies and develop novel therapeutic strategies

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21

Westfall, Carola Hammer 1953. "Bone mineral content of femur, lumbar vertebrae, and radius in eumenorrheic female athletes." Thesis, The University of Arizona, 1988. http://hdl.handle.net/10150/276757.

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This study compared bone mineral index (BMI, gm/cm²) of the femur, spine, and radius, measured by photon absorptiometry in various groups of eumenorrheic female athletes. The sample included body builders (11), swimmers (13), runners (5 collegiate, 11 recreational), and inactive controls (18) averaging 25 years of age, ranging from 17 to 38 years. Lumbar vertebral BMI for body builders (1.40 gm/cm²) was significantly (p ≤ 0.05) greater than controls (1.25 gm/cm²). The body builders' femoral neck BMI (1.09 gm/cm²) was significantly greater than swimmers (0.97 gm/cm², recreational runners and co

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22

De, Boef Maria Elizabeth. "Effects of phylogeny, physiology, and function on bone microstructure in extant endothermic vertebrates." Thesis, McGill University, 2010. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=86513.

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Abstract (sommario):

A strong relationship between bone macrostructural morphology and bone mechanical function has been well documented and is an essential component of many vertebrate biomechanical studies. However, a vastly richer data set could be had if the relationship between bone microstructure and bone function were as well understood. This thesis enumerates the bone microstructure-function relationship in a statistically consistent manor in extant endotherms.<br>Phylogeny, physiology and function have been shown to independently contribute to bone microstructure morphology. However, rarely have two or mo

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23

Micklesfield, Lisa Kim. "Exercise and bone mass in mature premenopausal women." Master's thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/26979.

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24

Akter, Rahima. "Role of lamin A/C in the cellular features of age-related bone loss." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=32525.

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Lamin A/C, an important component of the nuclear envelope, has been associated with cell differentiation and tissue development. In bone, recent studies have described that altered function of lamin A/C, due to mutations or incorrect processing, is associated with accelerated and severe bone loss. This could be due to alterations in the differentiation of mesenchymal stem cells (MSC) induced by lack of lamin A/C activity. Therefore, considering that decreased osteoblastogenesis and increased adipogenesis

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25

Young, Julia, and n/a. "Bone morphogenetic proteins are involved in controlling mammalian fertility." University of Otago. Department of Biochemistry, 2008. http://adt.otago.ac.nz./public/adt-NZDU20090112.122706.

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Transforming growth factor beta (TGFβ) superfamily members are involved in controlling mammalian fertility. The largest subset of the TGFβ superfamily are the bone morphogenetic proteins (BMP). BMP ligands signal through the type I and II BMP receptors and utilise the Smads1/5/8 phosphorylation cascade to control gene expression in the cell nucleus. Although BMPs act through the same pathway, they have the ability to activate unique sets of genes dependant on the identity of the ligand. In this study, HEK293T cells were challenged with BMP ligands for four hours and gene expression profiles we

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26

Yoo, Andrew Cha. "Hierarchical modeling of the mechanical behavior of human trabecular bone." Thesis, Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/17550.

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27

Lau, Hoi-lun, and 劉海倫. "Genetic and environmental determinants of bone mineral density in Southern Chinese." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31930633.

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28

Ward, Ryan C. "Contribution of high school sport participation to young adult bone strength." Thesis, University of Iowa, 2018. https://ir.uiowa.edu/etd/6333.

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Nearly 8 million American adolescents participate in sports. Many sports (e.g. basketball, volleyball) require powerful muscle movements. Normally, participation declines in young adulthood. The purpose of this study was to assess longitudinal effects of interscholastic high school sport participation and muscle power on young adult bone strength. 295 young adults from the Iowa Bone Development Study participated in this study. Participants were classified into sport participation groups based on an interscholastic sport participation history questionnaire. Groups included Power Sport Particip

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29

O'Neill, G. "Analysis of the physical and physiological events resulting from caloric irrigation of the human temporal bone." Thesis, University of South Wales, 1985. https://pure.southwales.ac.uk/en/studentthesis/analysis-of-the-physical-and-physiological-events-resulting-from-caloric-irrigation-of-the-human-temporal-bone(cfc9ee81-9359-4a9e-915f-6dcbf6263173).html.

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Analysis of results obtained from caloric tests showed that, on average, a significant sequential response decline was present for the four caloric responses. The effect of this decline was to produce an 'apparent 1 canal paresis of 4% of the second ear to be irrigated. There was no significant effect upon the calculation of directional preponderance. Also, differences in both maximum slow phase velocity and the latency of this maximum were found to exist between the warm and cold caloric responses. Although the difference of nystagmus intensities may be explained by the difference in the magn

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30

Bauldry, Sue Ann. "Factors influencing the in vitro proliferation of rat bone marrow fibroblasts /." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487259125218486.

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31

Croker, Sarah L. "Comparative cortical bone thickness in human and non-human mammal long bones : biomechanical and forensic perspectives." Thesis, The University of Sydney, 2011. https://hdl.handle.net/2123/24898.

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The determination of the human or non-human origin of skeletal material can be particularly difficult if the bone is fragmented. It has been suggested that differences in the thickness of the cortical bone between human and non-human mammal long bones may be used to distinguish them, though little clear data exist. The aim of this thesis was to determine the extent of such difference, and whether it could be used to identify fragments of bone shafts. Potential differences in cortical bone thickness were investigated by comparing adult human limb bones (humerus, radius, femur and tibia) w

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32

Yellowley, Clare Elizabeth. "Electrophysiological characterisation of human osteoblast-like cells." Thesis, University of Bristol, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240717.

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33

Graham, Jason Michael. "Mathematical representations in musculoskeletal physiology and cell motility." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/3305.

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Abstract (sommario):

Research in the biomedical sciences is incredibly diverse and often involves the interaction of specialists in a variety of fields. In particular, quantitative, mathematical, and computational methods are increasingly playing significant roles in studying problems arising in biomedical science. This is particularly exciting for mathematical modeling as the complexity of biological systems poses new challenges to modelers and leads to interesting mathematical problems. On the other hand mathematical modeling can provide considerable insight to laboratory and clinical researchers. In this thesis

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34

Warnock, Sarah M. "Cortical Bone Mechanics Technology (CBMT) and Dual X-Ray Absorptiometry (DXA) Sensitivity to Bone Collagen Degradation in Human Ulna Bone." Ohio University Honors Tutorial College / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1556305540256918.

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35

Zierath, Juleen R. "Bone mineral content in laboratory rats following swim and run training." Virtual Press, 1986. http://liblink.bsu.edu/uhtbin/catkey/472942.

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Increased bone density has been observed following physical training. However, it is not known whether the mechanical forces of muscular contraction, gravitational pull, or a combination of these forces are required to cause this adaptation. Therefore, the purpose of this study was to determine which mechanical force, muscular contraction or gravitational pull, offered the greatest contribution to increased bone mineral content observed following either swim or run training. METHODS: Female Wistar rats were randomly assigned to one of three groups: 1) Sedentary Control (SC; n = 12), 2) Run Tra

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36

Qian, Guofeng [Verfasser]. "Role of peroxisomes in physiology and pathology of ossification and bone metabolism / by Qian, Guofeng." Giessen : VVB Laufersweiler, 2011. http://d-nb.info/1010869108/34.

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37

Jones, Christopher David Stanford. "On the cross-sectional form of the patella in several primates." Title page, table of contents and abstract only, 2003. http://web4.library.adelaide.edu.au/theses/09PH/09phj764.pdf.

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38

Alfonso, Durruty Marta Pilar. "Biosignificance of Harris lines as stress markers in relation to moderate undernutrition and bone growth velocity a New Zealand white rabbit model for the study of bone growth /." Diss., Online access via UMI:, 2008.

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39

Milliken, Laura Ann 1970. "Bone mineral density, bone remodeling, insulin-like growth factors, hormone replacement therapy, and exercise training in postmenopausal women." Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282746.

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Osteoporosis is a condition of reduced bone mineral density (BMD) resulting in an increased susceptibility to bone fractures. The purpose of this study was to determine the effects of 12 months of weight bearing and resistance exercise on BMD, bone formation, measured by serum osteocalcin (OC) and bone resorption, measured by urinary excretion of deoxypyridinoline crosslinks (Dpd), in 2 groups of postmenopausal women who were either taking or not taking hormone replacement therapy (HRT). Secondary aims were to characterize the changes in insulin-like growth factors-l and -2 (IGF-l and -2) and

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40

Al, Kawas Sausan. "A comparative study of maturation processes in enamel and bone in the rat." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ36951.pdf.

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41

Panda, Dibyendu. "Role of Tuberoinfundibular peptide 39 (TIP 39)/ parathyroid hormone 2 receptor (PTH2R) signalling in the control of endochondral bone formation." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=104517.

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Parathyroid hormone (PTH) family members participate actively in various steps of endochondral bone development, in maintenance of bone health, and in mineral homeostasis. PTH type 2 receptor (PTH2R) and its ligand tuberoinfundibular peptide of 39 residues (TIP39) are recent additions to the PTH family of receptors and ligands. They are abundantly expressed in brain where it is proposed to possess neurotransmitter function.In this study, we demonstrate the presence of both TIP39 and PTH2R in the growth plate of murine long bones, and we show that the periarticular chondrocytes which express PT

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42

Conradie, Maria Martha. "Abnormalities of bone and mineral metabolism in patients with eating disorders." Thesis, Stellenbosch : Stellenbosch University, 2001. http://hdl.handle.net/10019.1/52058.

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Thesis (MScMedSc) -- Stellenbosch University, 2001.<br>ENGLISH ABSTRACT: Osteopenia is a well documented complication of anorexia nervosa (AN). The pathogenesis of this bone loss is presently poorly defined in the literature. Pathogenetic mechanisms that have been implicated include certain nutritional factors, exercise abuse, hypogonadism, hypercortisolism and/or vitamin 0 deficiency. We studied, 59 Caucasian eating disorder patients aged 15-45yr. The eating disorder was classified by a single, qualified psychiatrist according to OSM IV R criteria as either anorexia nervosa (AN: n =25

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43

Dreyer, Craig William. "Clast cell activity in a model of aseptic root resorption." Title page, table of contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09PH/09phd778.pdf.

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44

Shah, Karan Mehul. "The effects of clinically relevant concentrations of metal ions after hip replacement on bone cell physiology." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/6722/.

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45

Iordachescu, Alexandra. "An in-vitro model for the development of mature bone containing an osteocyte network." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8064/.

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Abstract (sommario):

Bone tissue continuously adapts to changes in mechanical load. This process can also result in a maladaptive ectopic bone response to mechanical insult, known as heterotopic ossification. The pathological differences at the molecular and structural levels are poorly understood. In vivo models exist but can often be too complex to allow isolation of factors which may stimulate disease progression. This thesis presents the development of a biologically self-structuring bone culture system using a fibrin gel which self-organises between two calcium phosphate anchors when seeded with cells. These

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46

容冠宇 and Koon-yu Samuel Yung. "Effects of green tea on bone loss in mature ovariectomized rat." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31970333.

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47

Briscoe, Adam. "Characterization and computational modelling of acrylic bone cement polymerisation." Thesis, University of Southampton, 2006. https://eprints.soton.ac.uk/64795/.

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Abstract (sommario):

Total joint replacement is one of the most successful surgical procedures and is a proven treatment for arthritis. Despite low failure rates, the wide application of the treatment means that large numbers of prostheses fail and must be revised. Improved pre-clinical testing methods for these orthopaedic devices may assist in developing new prostheses with improved clinical results. Computational modelling of biological systems is becoming increasingly accurate and is a much quicker and cheaper alternative to physical testing, but continued development is necessary to ensure computational model

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48

Kaluarachchi, Thambilipitiyage Kusumsiri Priyantha Kumara. "Impact of collagen type X deficiency on bone fracture healing." Thesis, Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk/hkuto/record.jsp?B23501807.

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49

Wilkins, Bridget Sally. "Cell-stroma interactions in haemopoiesis studied by immunocytochemistry and in situ hybridisation in long-term cultures and trephine biopsies of human bone marrow." Thesis, University of Southampton, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242221.

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50

Byrd, Alyson. "Evidence for a receptor binding 24R, 25-dihydroxyvitamin D3 in developing bone." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=21519.

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Although 24R,25(OH)2D3 has been implicated in bone development, its biological role and mechanism of action remain controversial. In search for evidence of a receptor, nuclear and cytosol extracts were isolated from mandibles and calvaria of E17.5 mice. Competition and saturation analysis identified a saturable, specific and high affinity (Kd=1.1nM) 24R,25(OH) 2D3 binding-protein. The results of these and sucrose sedimentation studies indicate that this protein is not vitamin D receptor (VDR) or vitamin D binding protein (DBP). Tissue specificity experiments suggest that this putative receptor

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