Tesi sul tema "Biochemical reactions"
Cita una fonte nei formati APA, MLA, Chicago, Harvard e in molti altri stili
Vedi i top-50 saggi (tesi di laurea o di dottorato) per l'attività di ricerca sul tema "Biochemical reactions".
Accanto a ogni fonte nell'elenco di riferimenti c'è un pulsante "Aggiungi alla bibliografia". Premilo e genereremo automaticamente la citazione bibliografica dell'opera scelta nello stile citazionale di cui hai bisogno: APA, MLA, Harvard, Chicago, Vancouver ecc.
Puoi anche scaricare il testo completo della pubblicazione scientifica nel formato .pdf e leggere online l'abstract (il sommario) dell'opera se è presente nei metadati.
Vedi le tesi di molte aree scientifiche e compila una bibliografia corretta.
Fradet, Etienne. "Monitoring biochemical reactions in stationary droplets". Palaiseau, Ecole polytechnique, 2013. http://pastel.archives-ouvertes.fr/docs/00/92/97/15/PDF/fradet_thesis_2013.pdf.
Testo completoDroplet microfluidics - i. E. The use of droplets as microreactors - offers significant advantages for the study of biological systems. In this work, we present a new platform for the production and manipulation of microfluidic droplets in view of measuring the evolution of biochemical reactions. Contrary to existing approaches, our device uses gradients of confinement to produce a single drop on demand and guide it to a pre-determined location. In this way, two nanoliter drops containing different reagents can be placed in contact and merged together in order to trigger a chemical reaction. Then, an analysis of the observed reaction front yields the reaction rate. We start with the case of one step reactions. We derive a one dimensional reaction-diffusion model for the reaction front and compare numerical and analytical solutions of our model to experiments held in our microsystem. Then, we turn our attention to the case of enzymatic reactions. First, we show how the device operation can be parallelized in order to react an initial sample with a range of compounds or concentrations and we perform standard well-mixed enzyme assays with our parallelized chip, thereby mimicking titer plate assays in droplets. Second, we build onto our reaction-diffusion model to predict the rate of fast enzymatic reactions held in our device. Again, numerical and analytical solutions of our model are compared to experiments done in droplets which yields measurements of the kinetic parameters of the reaction at play
Marrone, April. "THE BIOCHEMICAL REACTIONS OF DRY STATE DNA". Doctoral diss., University of Central Florida, 2009. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/3622.
Testo completoPh.D.
Department of Chemistry
Sciences
Chemistry PhD
Mistry, Dharmit. "Mechanistic studies of some chemical and biochemical reactions". Thesis, University of Huddersfield, 2014. http://eprints.hud.ac.uk/id/eprint/23444/.
Testo completoDubey, Nidhi Chandrama. "Smart hydrogels based platforms for investigation of biochemical reactions". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-184082.
Testo completoDavis, Aaron Vincent Tarn. "Chemical and Biochemical Redox Reactions of the Anticancer Drug Streptonigrin". Thesis, Queen Mary, University of London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.504553.
Testo completoGreenfield, Daniel Leo Computer Science & Engineering Faculty of Engineering UNSW. "New and hybrid methods for simulating biochemical systems". Awarded by:University of New South Wales. Computer Science and Engineering, 2006. http://handle.unsw.edu.au/1959.4/23990.
Testo completoLiu, Yang, e 刘洋. "Free energy simulations of important biochemical processes". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196036.
Testo completopublished_or_final_version
Chemistry
Doctoral
Doctor of Philosophy
Möller, Mark. "A hybrid algorithm for the simulation of biochemical reactions and diffusion". [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=982994052.
Testo completoGomez, David [Verfasser], e Stefan [Akademischer Betreuer] Klumpp. "Mechanisms of biochemical reactions within crowded environments / David Gomez ; Betreuer: Stefan Klumpp". Potsdam : Universität Potsdam, 2016. http://d-nb.info/1218400757/34.
Testo completoRajanayagam, Kavitha. "Chemical and biochemical redox reactions of the anthra quinone anticancer drug Mitoxantrone". Thesis, Queen Mary, University of London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417075.
Testo completoFlach, Edward H. "Reactions in open systems : pattern formation with convection, and open biochemical pathways". Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496888.
Testo completoYee, Yao-Chung. "Novel design of a passive microfluidic mixer for biochemical reactions and biosensing". [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1500.
Testo completoZimmer, Christoph [Verfasser], e Hans Georg [Akademischer Betreuer] Bock. "Parameter estimation for stochastic models of biochemical reactions / Christoph Zimmer ; Betreuer: Hans Georg Bock". Heidelberg : Universitätsbibliothek Heidelberg, 2012. http://d-nb.info/1179785401/34.
Testo completoDahl, Helen. "Ethyl glucuronide, a new biochemical marker for acute alcohol intake : studies on possible causes for false-negative or false-positive results /". Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-644-1/.
Testo completoHinzpeter, Florian [Verfasser], e Ulrich [Akademischer Betreuer] Gerland. "Kinetics of spatially organized biochemical reactions : optimal strategies and underlying physical principles / Florian Hinzpeter ; Betreuer: Ulrich Gerland". München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2018. http://d-nb.info/1191691330/34.
Testo completoOzogur, Sureyya. "Mathematical Modelling Of Enzymatic Reactions, Simulation And Parameter Estimation". Master's thesis, METU, 2005. http://etd.lib.metu.edu.tr/upload/12605856/index.pdf.
Testo completos) or differential algebraic equations (dae'
s). These equations are composed of kinetic parameters such as kinetic rate constants, initial rates and concentrations of metabolites. The non-linear nature of enzymatic reactions and large number of parameters cause trouble in efficient simulation of those reactions. Metabolic engineering tries to simplify these equations by reducing the number of parameters. In this work, enzymatic system which includes Creatine Kinase, Hexokinase and Glucose 6-Phosphate Dehydrogenase (CK-HK-G6PDH) is modeled in the form of dae'
s, solved numerically and the system parameters are estimated. The numerical results are compared with the results from an existing work in literature. We demonstrated that, our solution method based on direct solution of the CK-HK-G6PDH system significantly from simplified solutions. We also showed that genetic algorithm(GA) for parameter estimation, provides much clear results to the experimental values of the metabolite, especially with NADPH. Keywords: metabolic engineering, kinetic modelling, biochemical reactions, enzymatic reactions, differential algebraic equations, parameter estimation, genetic algorithm.
Hatcher, Anthony. "Comparison of Micrscan Identification and Susceptibility Testing Methods for Streptococcus Dysgalactiae to Conventional Biochemical Reactions and Kirby-Bauer Susceptibility Testing Methods". TopSCHOLAR®, 1994. http://digitalcommons.wku.edu/theses/970.
Testo completoDubey, Nidhi Chandrama [Verfasser], Manfred [Akademischer Betreuer] Stamm e Pée Karl-Heinz [Akademischer Betreuer] van. "Smart hydrogels based platforms for investigation of biochemical reactions / Nidhi Chandrama Dubey. Betreuer: Manfred Stamm. Gutachter: Manfred Stamm ; Karl-Heinz van Pée". Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://d-nb.info/1079468110/34.
Testo completoDubey, Nidhi C. [Verfasser], Manfred [Akademischer Betreuer] Stamm e Pée Karl-Heinz [Akademischer Betreuer] van. "Smart hydrogels based platforms for investigation of biochemical reactions / Nidhi Chandrama Dubey. Betreuer: Manfred Stamm. Gutachter: Manfred Stamm ; Karl-Heinz van Pée". Dresden : Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-184082.
Testo completoKagel, Heike [Verfasser], Frank Fabian [Akademischer Betreuer] Bier, Marcus [Akademischer Betreuer] Frohme, Jörn [Akademischer Betreuer] Glökler, Frank Fabian [Gutachter] Bier, Ilko [Gutachter] Bald e Michel [Gutachter] Köhler. "Light-induced pH cycle : a non-invasive method to control biochemical reactions / Heike Kagel ; Gutachter: Frank Fabian Bier, Ilko Bald, Michel Köhler ; Frank Fabian Bier, Marcus Frohme, Jörn Glökler". Potsdam : Universität Potsdam, 2019. http://d-nb.info/1218405104/34.
Testo completoAkintoye, Ayodele. "Continuous chromatographic biochemical reaction-separation". Thesis, Aston University, 1989. http://publications.aston.ac.uk/9739/.
Testo completoKhoshnaw, Sarbaz Hamza Abdullah. "Model reductions in biochemical reaction networks". Thesis, University of Leicester, 2015. http://hdl.handle.net/2381/32442.
Testo completoLawson, Christopher Peter Abiodun Tevi. "The development of novel myosin inhibitors". Thesis, University of St Andrews, 2011. http://hdl.handle.net/10023/2123.
Testo completoLester, Christopher. "Efficient simulation techniques for biochemical reaction networks". Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:bb804e01-b1de-409f-b843-4806c2c990c2.
Testo completoHuang, Xin. "Simulation of biochemical reaction and biophysical process". Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491955.
Testo completoSteiner-Oliveira, Carolina 1981. "Uso do laser de 'C'O IND. 2' ('lambda'=10,6 'mu') na prevenção da carie e erosão dentarias : estudos in vitro". [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/288091.
Testo completoTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba
Made available in DSpace on 2018-08-13T08:04:08Z (GMT). No. of bitstreams: 1 Steiner-Oliveira_Carolina_D.pdf: 11802864 bytes, checksum: 338ee3278fb157bb1cb37edb2e6d1a5d (MD5) Previous issue date: 2009
Resumo: Os efeitos causados pelas modificações promovidas pela irradiação com laser de CO2 podem inibir a desmineralização dos tecidos dentários e podem ser potencializados quando associados ao fluoreto. Apesar de amplo uso do fluoreto e da redução da prevalência de cárie, essa doença ainda acomete grupos de alto risco. Por outro lado, tem sido observado um aumento da prevalência da erosão dentária. Os objetivos dessa tese, composta por 4 manuscritos, foram: (1) descrever as características do laser de CO2 e seus mecanismos de ação na inibição da desmineralização do esmalte; (2) desenvolver um modelo microbiológico, in vitro, de produção de lesão de cárie em dentina e testar duas hipóteses: (a) de que não há diferença na produção de cárie artificial em dentina utilizando um modelo microbiológico com regimes de 3 e 6 imersões ao dia em sacarose, avaliados por contagem bacteriana da dentina (UFC), análise microrradiográfica (AM) e análise de polissacarídeo insolúvel (API); (b) de que não há diferença no pH do biofilme antes e após sua imersão em sacarose; (3) avaliar, in vitro, a efetividade do laser de CO2 (? = 10,6 µm) pulsado, associado ou não ao fluoreto, na redução da desmineralização da dentina radicular usando um modelo microbiológico, avaliado por AM; (4) avaliar, in vitro, o efeito do mesmo laser, associado ou não ao fluoreto, na redução da desmineralização do esmalte e da dentina submetidos a um desafio erosivo, pela mensuração da perda de superfície e análise da concentração de cálcio, fósforo e fluoreto das soluções desmineralizadoras. Os dados foram analisados quanto à normalidade e testes apropriados foram realizados com nível de significância de 5%. No estudo 1, os efeitos do laser no esmalte, seu mecanismo de ação na redução da desmineralização, combinados ou não ao fluoreto, foram discutidos. No estudo 2, o pH do biofilme diminuiu imediatamente após a imersão em sacarose, mas aumentou novamente 5 min depois. Lesões em dentina foram produzidas com sucesso e a adição de sacarose mostrou as maiores perdas minerais, no entanto não diferiu entre os dois regimes de sacarose. A UFC não mostrou nenhuma diferença e a API dos tratamentos foram maiores que a do grupo controle. No estudo 3, os espécimes radiculares foram tratados ou não com laser de CO2 e com ou sem fluoreto antes ou após a irradiação com laser. O modelo microbiológico utilizado foi efetivo em produzir lesões dentinárias e as terapias combinadas mostraram as lesões dentinárias mais rasas. No estudo 4, espécimes de esmalte e dentina foram tratados com fluoreto, laser e fluoreto/laser e submetidos a um desafio erosivo. Os resultados de desgaste indicaram que o tratamento combinado interferiu com as perdas minerais do esmalte e da dentina, mesmo sem mostrar efeito sinérgico. Houve uma tendência de retenção de fluoreto no esmalte pelo tratamento combinado e também de liberação de menores quantidades de cálcio, fósforo e fluoreto para as soluções desmineralizadoras. Em conclusão, o mecanismo de ação do laser de CO2 na inibição da desmineralização do esmalte ainda não está completamente esclarecido e seu efeito pode ser aumentado quando associado ao fluoreto. O modelo microbiológico foi efetivo em produzir lesões de cárie dentinária. A irradiação da dentina radicular com laser inibiu a desmineralização dessa superfície apenas quando associado com o fluoreto; no entanto, não foi observado efeito sinérgico. O tratamento isolado com laser não foi capaz de prevenir a perda de superfície do esmalte e da dentina devido à erosão. Sua combinação com fluoreto mostrou alguma proteção, mas principalmente devido ao efeito do fluoreto. Não foi observada interação sinérgica significativa ou proteção duradoura com a terapia de laser.
Abstract: The effects caused by the modifications promoted by the CO2 laser irradiation can inhibit the dental tissues demineralization and may be enhanced when associated with fluoride. Despite the widespread use of the fluoride and the reduction of the caries prevalence, this disease still occurs in the high risk groups. On the other hand, an increase of the dental erosion prevalence was observed. This thesis, comprised by 4 manuscripts, aimed: (1) to describe the CO2 laser characteristics and its action mechanisms in the enamel demineralization inhibition; (2) to develop an in vitro microbial model to produce dentin caries lesions and test two hypotheses - (a) that there is no difference in the artificial caries production in dentin using a microbial model with 3 and 6 sucrose bath immersions, as assessed by bacterial counts on the dentin (CFU), microradiographic analysis (TMR) and extracellular polysaccharide analysis (EPS); (b) that there is no difference in the biofilm pH before and after each sucrose bath; (3) to assess, in vitro, the effectiveness of a pulsed CO2 laser (? = 10.6 µm) associated or not with fluoride, in reducing the root demineralization using a microbial model, as assessed by TMR; (4) to assess, in vitro, the effect of the same laser, associated or not with fluoride, on the prevention of the enamel and dentin erosions by means of surface loss measurement and analysis of the calcium, phosphorus and fluoride concentrations in the demineralizing solutions. The data were checked for normality and appropriated tests were performed with a significance level of 5%. In study 1, the laser effects on the enamel and its action mechanisms in the demineralization reduction, combined or not with fluoride, were discussed. In study 2, the biofilm pH decreased immediately after the sucrose bath but increased again after 5 min. Dentin lesions were successfully produced, and the sucrose addition showed the highest mineral losses, even though there was no difference between the sucrose regimens. The CFU did not show any difference and the EPS from the treatment groups were higher than for the control. In study 3, root specimens were treated with/without CO2 laser and with/without fluoride prior or after the laser irradiation. The microbial model utilized was effective in developing dentin lesions and the combined therapies showed the shallowest dentin lesions. In study 4, specimens of enamel and root dentin were treated with fluoride, laser and fluoride/laser and submitted to an erosive challenge. The wear results indicated that the combined treatment interfered with the enamel or dentin surface losses, although no synergistic effect was observed. There was a trend for the combined treatment to retain more fluoride in enamel and release lower amounts of calcium and phosphorus into the demineralizing solutions. In conclusion, the CO2 mechanism action on the enamel demineralization reduction is still not elucidated and its effects can be increased when associated with fluoride. The microbial model was effective in producing dentin caries lesions. However, it did not reproduce the remineralizing phase of the caries process. Irradiation of the root dentin with laser inhibited the root surface demineralization only when associated with fluoride; however, no synergic effect was observed. The laser treatment alone was not able to prevent enamel or dentin surface losses due to erosion. Its combination with fluoride showed some protection, but mostly due to the fluoride effect. No significant synergistic interaction or lasting protection could be observed for the laser therapy.
Doutorado
Odontopediatria
Doutor em Odontologia
Wu, Jialiang. "Hybrid modeling and analysis of multiscale biochemical reaction networks". Diss., Georgia Institute of Technology, 2011. http://hdl.handle.net/1853/47723.
Testo completoGeffen, Dara. "Parameter identifiability of biochemical reaction networks in systems biology". Thesis, Kingston, Ont. : [s.n.], 2008. http://hdl.handle.net/1974/1347.
Testo completoLi, Fei. "Stochastic Modeling and Simulation of Reaction-Diffusion Biochemical Systems". Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/64913.
Testo completoPh. D.
Jenkins, Robert. "Deterministic and stochastic modelling of chemical and biochemical reaction kinetics". Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.495585.
Testo completoLeising, Sophie. "Nonlinear controller synthesis for complex chemical and biochemical reaction systems". Link to electronic thesis, 2005. http://www.wpi.edu/Pubs/ETD/Available/etd-050205-152657/.
Testo completoKeywords: model predictive control; discrete-time model; continuous-time model; nonlinear systems; Lyapunov design. Includes bibliographical references (p. 99-102).
Woo, Sung Sik Ph D. Massachusetts Institute of Technology. "Fast simulation of stochastic biochemical reaction networks on cytomorphic chips". Thesis, Massachusetts Institute of Technology, 2016. http://hdl.handle.net/1721.1/107292.
Testo completoThis electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from student-submitted PDF version of thesis.
Includes bibliographical references (pages 169-181).
The large-scale simulation of biochemical reaction networks in cells is important in pathway discovery in medicine, in analyzing complex cell function in systems biology, and in the design of synthetic biological circuits in living cells. However, cells can undergo many trillions of reactions over just an hour with multi-scale interacting feedback loops that manifest complex dynamics; their pathways exhibit non-modular behavior or loading; they exhibit high levels of stochasticity (noise) that require ex- pensive Gillespie algorithms and random-number generation for accurate simulations; and, they routinely operate with nonlinear statics and dynamics. Hence, such simulations are extremely computationally intensive and have remained an important bottleneck in computational biology over decades. By exploiting common mathematical laws between electronics and chemistry, this thesis demonstrates that digitally programmable analog integrated-circuit 'cytomorphic' chips can efficiently run stochastic simulations of complex molecular reaction networks in cells. In a proof-of-concept demonstration, we show that 0.35 [mu]m BiC- MOS cytomorphic gene and protein chips that interact via molecular data packets with FPGAs (Field Programmable Gate Arrays) to simulate networks involving up to 1,400 biochemical reactions can achieve a 700x speedup over COPASI, an efficient bio- chemical network simulator. They can also achieve a 30,000x speedup over MATLAB. The cytomorphic chips operate over five orders of magnitude of input concentration; they enable low-copy-number stochastic simulations by amplifying analog thermal noise that is consistent with Gillespie simulations; they represent non-modular load- ing effects and complex dynamics; and, they simulate zeroth, first, and second-order linear and nonlinear gene-protein networks with arbitrary parameters and network connectivity that can be flexibly digitally programmed. We demonstrate successful stochastic simulation of a p53 cancer pathway and glycolytic oscillations that are consistent with results obtained from conventional digital computer simulations, which are based on experimental data. We show that unlike conventional digital solutions, an increase in network scale or molecular population size does not compromise the simulation speed and accuracy of our completely parallel cytomorphic system. Thus, commonly used circuit improvements to future chips in our digital-to-analog converters, noise generators, and biasing circuits can enable further orders of magnitude of speedup, estimated to be a million fold for large-scale networks.
by Sung Sik Woo.
Ph. D.
Koyama, M., R. Imai, M. Shikida, M. Okochi, H. Tsuchiya, H. Honda, K. Sato e 一雄 佐藤. "Micromachined sample divider for analyzing biochemical reaction based on single molecules". IEEE, 2008. http://hdl.handle.net/2237/11138.
Testo completoAllen, Nicholas A. "Computational Software for Building Biochemical Reaction Network Models with Differential Equations". Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/30059.
Testo completoPh. D.
Allen, Nicholas Alexander. "Computational Software for Building Biochemical Reaction Network Models with Differential Equations". Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/30059.
Testo completoPh. D.
Sarmidi, M. R. "Simultaneous biochemical reaction and separation in a continuous rotating annular chromatograph". Thesis, Aston University, 1993. http://publications.aston.ac.uk/9767/.
Testo completoNguyen, Vu ngoc tung. "Analysis of biochemical reaction graph : application to heterotrophic plant cell metabolism". Thesis, Bordeaux, 2015. http://www.theses.fr/2015BORD0023/document.
Testo completoNowadays, systems biology are facing the challenges of analysing the huge amount of biological data and large-scale metabolic networks. Although several methods have been developed in recent years to solve this problem, it is existing hardness in studying these data and interpreting the obtained results comprehensively. This thesis focuses on analysis of structural properties, computation of elementary flux modes and determination of minimal cut sets of the heterotrophic plant cellmetabolic network. In our research, we have collaborated with biologists to reconstructa mid-size metabolic network of this heterotrophic plant cell. This network contains about 90 nodes and 150 edges. First step, we have done the analysis of structural properties by using graph theory measures, with the aim of finding its owned organisation. The central points orhub reactions found in this step do not explain clearly the network structure. The small-world or scale-free attributes have been investigated, but they do not give more useful information. In the second step, one of the promising analysis methods, named elementary flux modes, givesa large number of solutions, around hundreds of thousands of feasible metabolic pathways that is difficult to handle them manually. In the third step, minimal cut sets computation, a dual approach of elementary flux modes, has been used to enumerate all minimal and unique sets of reactions stopping the feasible pathways found in the previous step. The number of minimal cut sets has a decreasing trend in large-scale networks in the case of growing the network size. We have also combined elementary flux modes analysis and minimal cut sets computation to find the relationship among the two sets of results. The findings reveal the importance of minimal cut sets in use of seeking the hierarchical structure of this network through elementary flux modes. We have set up the circumstance that what will be happened if glucose entry is absent. Bi analysis of small minimal cut sets we have been able to found set of reactions which has to be present to produce the different sugars or metabolites of interest in absence of glucose entry. Minimal cut sets of size 2 have been used to identify 8 reactions which play the role of the skeleton/core of our network. In addition to these first results, by using minimal cut sets of size 3, we have pointed out five reactions as the starting point of creating a new branch in creationof feasible pathways. These 13 reactions create a hierarchical classification of elementary flux modes set. It helps us understanding more clearly the production of metabolites of interest inside the plant cell metabolism
Cheng, Yuhui. "Multiscale simulations of biochemically reacting systems". Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3274520.
Testo completoTitle from first page of PDF file (viewed Oct. 3, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 117-134).
Liu, Gu. "Target identification and validation studies in chemical biology & Synthesis of medium-sized ring containing compounds via oxidative fragmentation". Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/986.
Testo completoHughes, Alistair Paul. "The accuracy of linear flux models in predicting reaction rate profiles in a model biochemical reaction system". Master's thesis, University of Cape Town, 2014. http://hdl.handle.net/11427/9116.
Testo completoMetabolic flux analysis is commonly used in the modelling of biochemical reactions. The use of MFA models has gained large amounts of interest due to the simplicity of the computational procedures required for the model, and the exclusion of difficult to measure intracellular reaction data. There are many examples of the use of MFA models in literature studies in a number of applications, ranging from the medical industry through to the development of novel biochemical processes. Little to no mention is provided in literature studies regarding the applicability of the MFA model to a specified set of reaction data. Furthermore, the techniques and routines used to compute the flux models are not well described in these studies. The objectives of this research were to determine the sensitivity of the MFA models to various operating and kinetic parameters and to highlight the considerations required when setting up the computational routine used to solve the flux balances. The study was conducted using a model pathway populated with a set of hypothetical elemental reactions and branch points. The model pathway was used in this study to negate the affects of complex regulatory biochemical architectures which are not well described in literature. The use of the model pathway ensured that the reaction system was thermodynamically feasible and there was consistency in the mass balances. The exclusion of the complex regulatory reactions did not affect the accuracy of the results generated in this study. A set of reaction mechanisms were used to describe each reaction step and were populated with parameters reference from literature. The cellular and reactor mass balances were generated using correlations presented in literature.
Ng, Sau-wah. "Population genetics study on the variable number of Tandem repeats (VNTR) loci of a Han Chinese population in Hong Kong and its application in human identity". Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2292582X.
Testo completoHauser, Anett. "Chemical Approaches to Elucidate Lysine Phosphorylation". Doctoral thesis, Humboldt-Universität zu Berlin, 2021. http://dx.doi.org/10.18452/22287.
Testo completoReversible phosphorylation is the most prominent post-translational modification (PTM) and the O-phosphomonoesters of serine, threonine and tyrosine have been considered as the only notable forms for long time. Recent developments have paved the way to insights into the biological relevance of labile phosphorylations, e.g. phosphorylation of histidine, arginine and cysteine as well as pyrophosphorylation of serine and threonine. Also, the elucidation of phospho-lysine (pLys) was tackled with the establishment of a chemoselective synthesis to obtain site-selectively phosphorylated lysine peptides and the development of mass spectrometric protocols to unambiguously identify modification sites. Nonetheless, no endogenous pLys site has been described or in-depth investigations of interacting enzymes have been conducted. In this thesis, several approaches to enhance the knowledge about pLys are introduced. These include the design of an alternative synthesis route to pLys peptides and the development as well as evaluation of two stable analogues as building blocks for peptide synthesis. Furthermore, the protonation of the phosphoramidate-nitrogen was investigated. In systematic phosphoramidate hydrolase and phosphatase activity assays, the interactions between phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP) and various phospho-substrates were examined. Thereby, distinct selectivity for pLys, high sequence dependence of LHPP activity and a distinct binding motif were revealed. In addition to that, proteomic methods were evaluated regarding their suitability for pLys peptides. Over the course of this investigation, several pLys immunogens for the generation of monoclonal anti-pLys antibodies and a workflow for histone separation and analysis were developed. Furthermore, chelation-enhanced fluorescence of labeled phospho-peptides was studied as a tool for determining the degree of phosphorylation in enzyme activity or stability assays.
Linar, Mikeev [Verfasser], e Verena [Akademischer Betreuer] Wolf. "Numerical analysis of stochastic biochemical reaction networks / Mikeev Linar ; Betreuer: Verena Wolf". Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2018. http://d-nb.info/1160938695/34.
Testo completoHajiaghayi, Monir. "Study of two biochemical models : chemical reaction networks, and nucleic acid systems". Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/63311.
Testo completoScience, Faculty of
Computer Science, Department of
Graduate
Hellander, Andreas. "Numerical simulation of well stirred biochemical reaction networks governed by the master equation". Licentiate thesis, Uppsala universitet, Avdelningen för teknisk databehandling, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-85856.
Testo completoSamal, Satya Swarup [Verfasser]. "Analysis of Biochemical Reaction Networks using Tropical and Polyhedral Geometry Methods / Satya Swarup Samal". Bonn : Universitäts- und Landesbibliothek Bonn, 2016. http://d-nb.info/1124540091/34.
Testo completoMenz, Stephan [Verfasser]. "Hybrid stochastic-deterministic approaches for simulation and analysis of biochemical reaction networks / Stephan Menz". Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1031667121/34.
Testo completoÜrgüplü, Belma Asli. "Contributions to symbolic effective qualitative analysis of dynamical systems : application to biochemical reaction networks". Thesis, Lille 1, 2010. http://www.theses.fr/2010LIL10013/document.
Testo completoThe goal of my research is to make algorithmic, as much as possible, the study of models composed by parametric differential equations. I focus on the algorithms based on expanded Lie point symmetries for medium size (about twenty variables) models. I present two exact simplification methods: the reduction of the number of variables of a model and its reparametrization in order to distinguish the roles of its parameters. Simplified systems are equivalent to the original ones by implicit or explicit relationships (according to the chosen method). These algorithms, thanks to some computational strategies and restriction of studied objects, are of polynomial time complexity in the input size. They are implemented in the MABSys and the ExpandedLiePointSymmetry packages. Simplified models resulting from these methods allow to perform more easily various studies such as symbolic or numerical qualitative analysis. I illustrate my work on a family of genetic networks with a single self-regulated gene by a complete symbolic qualitative analysis. Even if my principal application example belongs to genetic regulatory networks field, the methods presented in my work are not limited to intracellular biology
Sjöberg, Paul. "Numerical Methods for Stochastic Modeling of Genes and Proteins". Doctoral thesis, Uppsala universitet, Avdelningen för teknisk databehandling, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8293.
Testo completoCatti, Federica. "4,5-dihydropyrazoles : novel chemistry and biological activity". Thesis, St Andrews, 2007. http://hdl.handle.net/10023/351.
Testo completo