Articoli di riviste: "Bio-prosthesis"

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Bryssinck, Laure, Siel De Vlieger, Katrien François e Thierry Bové. "Post hoc patient satisfaction with the choice of valve prosthesis for aortic valve replacement: results of a single-centre survey". Interactive CardioVascular and Thoracic Surgery 33, n. 2 (2 aprile 2021): 210–17. http://dx.doi.org/10.1093/icvts/ivab069.

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Abstract OBJECTIVES Our goal was to examine post hoc patient satisfaction and the decision-making process of choosing a prosthesis for aortic valve replacement (AVR). METHODS We surveyed 113 patients who were operated on for AVR at 60–70 years of age, including 74 patients with a mechanical valve (MECH) and 39 with a bioprosthesis (BIO). The study focused on quality of life and the decision pathway in relation to prosthesis choice and valve-related complications. Decisional conflict was defined as the post hoc uncertainty perceived by patients regarding their choice of prosthesis. RESULTS The survey was performed at a median of 5.2 (3.2–8.1) years after the AVR. Patients with a biological valve were older (BIO: 68.4 years [66.2–69.4] vs MECH: 63.9 [61.9–66.7]; P < 0.001). Global post hoc satisfaction with prosthesis choice was high in both groups (MECH: 95.9%; BIO: 100%), and 85.1% (MECH) and 92.3% (BIO) of them would repeat their choice. Conflict about their decision was equal (MECH: 30.3%; BIO: 32.6%) for different reasons: MECH patients experienced more anticoagulation-related inconvenience (25.9% vs 0%), fear of bleeding (31.1% vs 0%) and prosthesis noise (26.2% vs 0%), whereas more BIO patients feared prosthesis failure (39.7% vs 17.4%) or reoperation (43.5% vs 18.1%). Active involvement in the decision (odds ratio 0.37, 95% confidence interval 0.16–0.85; P = 0.029) and adequate information about the prosthesis (odds ratio 0.34, 95% confidence interval 0.14–0.86; P = 0.020) decreased the risk of conflict about the decision. CONCLUSIONS Although 30% of the responders showed a decisional conflict related to prosthesis-specific interferences, global patient satisfaction with the prosthesis choice for AVR is excellent. Increasing the patient’s involvement in the prosthesis choice through shared accountability and improved information is recommended to decrease the choice-related uncertainty.

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Lin, Chin-Yu, Wan-Shiun Lou, Jyh-Chern Chen, Kuo-Yao Weng, Ming-Cheng Shih, Ya-Wen Hung, Zhu-Yin Chen e Mei-Chih Wang. "Bio-Compatibility and Bio-Insulation of Implantable Electrode Prosthesis Ameliorated by A-174 Silane Primed Parylene-C Deposited Embedment". Micromachines 11, n. 12 (30 novembre 2020): 1064. http://dx.doi.org/10.3390/mi11121064.

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Microelectrodes for pain management, neural prosthesis or assistances have a huge medical demand, such as the application of pain management chip or retinal prosthesis addressed on age-related macular degeneration (AMD) and the retinitis pigmentosa (RP). Due to lifelong implanted in human body and direct adhesion of neural tissues, the electrodes and associated insulation materials should possess an ideal bio-compatibility, including non-cytotoxicity and no safety concern elicited by immune responses. Our goal intended to develop retinal prosthesis, an electrical circuit chip used for assisting neural electrons transmission on retina and ameliorating the retinal disability. Therefore, based on the ISO 10993 guidance for implantable medical devices, the electrode prosthesis with insulation material has to conduct bio-compatibility assessment including cytotoxicity, hemolysis, (skin) irritation and pathological implantation examinations. In this study, we manufactured inter-digitated electrode (IDE) chips mimic the electrode prosthesis through photolithography. The titanium and platinum composites were deposited onto a silicon wafer to prepare an electric circuit to mimic the electrode used in retinal prosthesis manufacture, which further be encapsulated to examine the bio-compatibility in compliance with ISO 10993 and ASTM guidance specifically for implantable medical devices. Parylene-C, polyimide and silicon carbide were selected as materials for electrode encapsulation in comparison. Our data revealed parylene-C coating showed a significant excellence on bio-insulation and bio-compatibility specifically addressed on implantable neuron stimulatory devices and provided an economic procedure to package the electrode prosthesis. Therefore, parylene C encapsulation should serve as a consideration for future application on retinal prosthesis manufacture and examination.

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Petlin, K. A., E. A. Kosovskikh, E. V. Lelik e B. N. Kozlov. "Comparative analysis of hemodynamic characteristics of the biological xenogenic pericardial prosthesis MEDINGE-BIO with “easy change” system and the xenogenic aortic prosthesis Hancock II after aortic valve replacement". Russian Journal of Cardiology 26, n. 8 (4 settembre 2021): 4533. http://dx.doi.org/10.15829/1560-4071-2021-4533.

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Aim. To compare the outcomes of aortic valve replacement using the xenogenic aortic prosthesis Hancock II and the novel Russian xenogenic pericardial prosthesis MEDINGE-BIO.Material and methods. The study included patients operated on for aortic stenosis in the cardiac surgery department № 1 of the Cardiology Research Institute (Tomsk National Research Medical Center). All patients were divided into two groups. The first group included 54 patients with Hancock II prostheses, the second — 91 patients with MEDINGE-BIO prostheses. Hemodynamic characteristics of heart valves were assessed by echocardiography before surgery and before discharge (on average 10 days after surgery).Results. When comparing hemodynamic parameters before and after surgery, significant differences between the groups were not obtained. The average pressure gradient after surgery using Hancock II and MEDINGE-BIO prosthesis was 21,6±7,9 and 17,9±5,6 mm Hg, respectively (p=0,05).Conclusion. The comparative analysis showed that the novel biological prosthesis MEDINGE-BIO has comparable hemodynamic characteristics with the well-known aortic prosthesis Hancock II.

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Zav′yalov, Sergey, e Alexander Meigal. "He bio-controlled prosthesis technologies today and tomorrow". Journal of Biomedical Technologies, n. 2 (dicembre 2015): 36–42. http://dx.doi.org/10.15393/j6.art.2015.3342.

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Di Bartolomeo, R., L. Botta, A. Leone, E. Pilato, S. Martin-Suarez, M. Bacchini e D. Pacini. "Bio-ValsalvaTM prosthesis: 'new' conduit for 'old' patients". Interactive CardioVascular and Thoracic Surgery 7, n. 6 (1 dicembre 2008): 1062–66. http://dx.doi.org/10.1510/icvts.2008.187849.

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Alkhawam, Hassan, Michael Lim, Richard Lee, Dawn S. Hui, Steven Smart e Tarek Helmy. "AORTIC BALLOON VALVULOPLASTY CAN BE USED TO “STRETCH” BIO-PROSTHESIS IN PATIENT PROSTHESIS MISMATCH". Journal of the American College of Cardiology 71, n. 11 (marzo 2018): A2241. http://dx.doi.org/10.1016/s0735-1097(18)32782-7.

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Plesec, Vasja, Jani Humar, Polona Dobnik-Dubrovski e Gregor Harih. "Numerical Analysis of a Transtibial Prosthesis Socket Using 3D-Printed Bio-Based PLA". Materials 16, n. 5 (28 febbraio 2023): 1985. http://dx.doi.org/10.3390/ma16051985.

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Lower-limb prosthesis design and manufacturing still rely mostly on the workshop process of trial-and-error using expensive unrecyclable composite materials, resulting in time-consuming, material-wasting, and, ultimately, expensive prostheses. Therefore, we investigated the possibility of utilizing Fused Deposition Modeling 3D-printing technology with inexpensive bio-based and bio-degradable Polylactic Acid (PLA) material for prosthesis socket development and manufacturing. The safety and stability of the proposed 3D-printed PLA socket were analyzed using a recently developed generic transtibial numeric model, with boundary conditions of donning and newly developed realistic gait cycle phases of a heel strike and forefoot loading according to ISO 10328. The material properties of the 3D-printed PLA were determined using uniaxial tensile and compression tests on transverse and longitudinal samples. Numerical simulations with all boundary conditions were performed for the 3D-printed PLA and traditional polystyrene check and definitive composite socket. The results showed that the 3D-printed PLA socket withstands the occurring von-Mises stresses of 5.4 MPa and 10.8 MPa under heel strike and push-off gait conditions, respectively. Furthermore, the maximum deformations observed in the 3D-printed PLA socket of 0.74 mm and 2.66 mm were similar to the check socket deformations of 0.67 mm and 2.52 mm during heel strike and push-off, respectively, hence providing the same stability for the amputees. We have shown that an inexpensive, bio-based, and bio-degradable PLA material can be considered for manufacturing the lower-limb prosthesis, resulting in an environmentally friendly and inexpensive solution.

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Vitanova, Keti, Felix Wirth, Johannes Boehm, Melchior Burri, Rüdiger Lange e Markus Krane. "Surgical Aortic Valve Replacement—Age-Dependent Choice of Prosthesis Type". Journal of Clinical Medicine 10, n. 23 (26 novembre 2021): 5554. http://dx.doi.org/10.3390/jcm10235554.

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Background: Recently, the use of surgically implanted aortic bioprostheses has been favoured in younger patients. We aimed to analyse the long-term survival and postoperative MACCE (Major Adverse Cardiovascular and Cerebral Event) rates in patients after isolated aortic valve replacement. Methods: We conducted a single-centre observational retrospective study, including all consecutive patients with isolated aortic valve replacement. 1:1 propensity score matching of the preoperative baseline characteristics was performed. Results: A total of 2172 patients were enrolled in the study. After propensity score matching the study included 428 patients: 214 biological vs. 214 mechanical prostheses, divided into two subgroups: group A < 60 years and group B > 60 years. The mean follow-up time was 7.6 ± 3.9 years. Estimated survival was 97 ± 1.9% and 89 ± 3.4% at 10 years for biological and mechanical prosthesis, respectively in group A (p = 0.06). In group B the survival at 10 years was 79.1 ± 5.8% and 69.8 ± 4.4% for biological and mechanical prosthesis, respectively (p = 0.83). In group A, patients with a bioprosthesis exhibited a tendency for higher cumulative incidence MACCE rates compared to patients with a mechanical prosthesis, p = 0.83 (bio 7.3 ± 5.3% vs. mech 4.6 ± 2.2% at 10 years). In group B, patients with a mechanical prosthesis showed a tendency for higher cumulative incidence MACCE rates compared to patients with bioprosthesis, p = 0.86 (bio 4.3 ± 3.1% vs. mech 9.1 ± 3.1% at 10 years). Conclusions: Long-term survival after surgical aortic valve replacement is similar in patients with a biological and mechanical prosthesis, independent of the patients’ age. Moreover, younger patients (<60 years) with bioprosthesis showed a survival benefit, compared to patients with mechanical prosthesis in this age group.

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Nsugbe, Ejay, Oluwarotimi Williams Samuel, Mojisola Grace Asogbon e Guanglin Li. "A Self-Learning and Adaptive Control Scheme for Phantom Prosthesis Control Using Combined Neuromuscular and Brain-Wave Bio-Signals". Engineering Proceedings 2, n. 1 (14 novembre 2020): 59. http://dx.doi.org/10.3390/ecsa-7-08169.

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The control scheme in a myoelectric prosthesis includes a pattern recognition section whose task is to decode an input signal, produce a respective actuation signal and drive the motors in the prosthesis limb towards the completion of the user’s intended gesture motion. The pattern recognition architecture works with a classifier which is typically trained and calibrated offline with a supervised learning framework. This method involves the training of classifiers which form part of the pattern recognition scheme, but also induces additional and often undesired lead time in the prosthesis design phase. In this study, a three-phase identification framework is formulated to design a control architecture capable of self-learning patterns from bio-signal inputs from electromyography (neuromuscular) and electroencephalography (brain wave) biosensors, for a transhumeral amputee case study. The results show that the designed self-learning framework can help reduce lead time in prosthesis control interface customisation, and can also be extended as an adaptive control scheme to minimise the performance degradation of the prosthesis controller.

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Skhunov, M., A. N. Solodukhin, P. Giannakou, L. Askew, Yu N. Luponosov, D. O. Balakirev, N. K. Kalinichenko, I. P. Marko, S. J. Sweeney e S. A. Ponomarenko. "Pixelated full-colour small molecule semiconductor devices towards artificial retinas". Journal of Materials Chemistry C 9, n. 18 (2021): 5858–67. http://dx.doi.org/10.1039/d0tc05383j.

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Variable bandgap conjugated donor–acceptor small molecule thin films show absorption spectra similar to those of human eye's photoreceptors. Photoactive devices interfaced with a bio-electrolyte reveal capacitive photocurrent response making them suitable for future full-colour retinal prosthesis.

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Kozlov, B. N., K. A. Petlin, A. S. Pryakhin, A. V. Schedrin, D. S. Panflov e V. M. Shipulin. "The first clinical case of implantation of a composite frame xenopericardial bioprosthesis “MedEng-Bio” in the mitral position". Bulletin of Siberian Medicine 17, n. 4 (24 dicembre 2018): 281–86. http://dx.doi.org/10.20538/1682-0363-2018-4-281-286.

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The article presents the first clinical case of the implantation of a composite frame xenopericardial bioprosthesis “MedEng-Bio” in the mitral position. The special design of the prosthesis implantation procedure simplifies and reduces the risks associated with possible repeated operations.

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Jafari Chashmi, Morassa, Alireza Fathi, Masoud Shirzad, Ramazan-Ali Jafari-Talookolaei, Mahdi Bodaghi e Sayed Mahmood Rabiee. "Design and Analysis of Porous Functionally Graded Femoral Prostheses with Improved Stress Shielding". Designs 4, n. 2 (2 giugno 2020): 12. http://dx.doi.org/10.3390/designs4020012.

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One of the most important problems of total hip replacement is aseptic loosening of the femoral component, which is related to the changes of the stress distribution pattern after implantation of the prosthesis. Stress shielding of the femur is recognized as a primary factor in aseptic loosening of hip replacements. Utilizing different materials is one of the ordinary solutions for that problem, but using functionally graded materials (FGMs) could be better than the conventional solutions. This research work aims at investigating different porous FGM implants and a real femoral bone by a 3D finite element method. The results show that a neutral functionally graded prosthesis cannot extraordinarily make changes in the stress pattern of bone and prosthesis, but an increasing functionally graded prosthesis leads a lower level of stress in the prosthesis, and a decreasing functionally graded prosthesis can properly reduce the stress shielding among these three architectures. Due to the absence of similar results in the specialized literature, this paper is likely to fill a gap in the state-of-the-art bio-implants, and provide pertinent results that are instrumental in the design of porous femoral prostheses under normal walking loading conditions.

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Maache, Abdelhak, Moussa Amadji, Hacene Ameddah e Hammoudi Mazouz. "The numerical simulation of a new biomimetic silicone layer component of total knee prosthesis". Russian journal of biomechanics. 28, n. 1 (29 marzo 2024): 66–75. http://dx.doi.org/10.15593/rjbiomech/2024.1.06.

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The knee osteoarthritis requires the latter joint replacement by a total knee prosthe-sis (TKP). Generally, this prosthesis consists of three parts; a femoral component in CoCrMo cobalt alloy, a tibial insert in polyethylene, and a tibial tray in titanium alloy Ti6AL4V. This type of prosthesis is not 100 % comfortable, after years of implantation, the tibial insert (polyethylene) degrades and gives more wear debris, which affects the bio-functionality of this prosthesis and the patient life. In this study, two models of total knee prosthesis are designed and analyzed using SolidWorks and Ansys software, the first model is the existing three-part prosthesis, and the second model is based on the theory of Mooney – Rivlin method prosthesis with a new layer of silicone component. In this paper, shock simulation of a free fall from a height of 75 cm is studied. The results of the displacement comparison between the first model 0.039 mm, and the second model 1.41 mm. In comparison with the contraction of the biological knee joint show that the second model has a contraction closer to the biological knee. It can be deduced that this total knee prosthesis has a hyper-elastic behavior closer to the behavior of a biological knee as well, which gives more stability and provides a cushioning role for the knee compared to the existing TKP.

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Flores-Luna, Rosa Itzel, Jesús Manuel Dorador-González e Adrian Espinosa-Bautista. "Prosthesis Analysis Based on TRIZ". Key Engineering Materials 572 (settembre 2013): 135–38. http://dx.doi.org/10.4028/www.scientific.net/kem.572.135.

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The Mechanical and Technological Innovation Centre (CDMIT) of the National Autonomous University of Mexico has a research area focused on the design of upper limb prosthesis. A large number of prosthesis have been developed and tested. This paper presents the analysis made to different proposals of myoelectric hands based on TRIZ. Two TRIZ tools were applied: The Innovation Situation Questionnaire (ISQ) and the Radar of Evolution. The analysis was made in terms of time, space and the user interface. The ISQ helps to better define the scope of the problem through six basic questions; each question provides a different view of the problem. The radar of evolution helps to make a selection of trends of evolution depending on the product or system, as an analogy of a benchmark. The analysis was made considering the state-of-the-art hand prosthesis: i-limb, be-bionic, Michelangelo and Myohand against the prosthesis prototypes developed by the CDMIT. The result of this tool is a diagram that reveals the level and opportunities of evolution. These opportunities imply a strengthening of research areas not only in the CDMIT but around the world. The conclusion achieved is that different design paradigms linked to bio-mimics criteria are needed to design more innovative user-friendly prosthesis.

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Zhang, Ya Rui, Shi Jie Li, Hai Xia Bi e Jin He Liu. "Study on Reforger and Biology Mechanics of Individual Femur". Advanced Materials Research 197-198 (febbraio 2011): 36–42. http://dx.doi.org/10.4028/www.scientific.net/amr.197-198.36.

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The artificial prosthesises currently used are only different in the femoral head size, neck length and stem thickness, but there is not any individualized prosthesis. At present, prosthesis looseness is the main problem of artificial femoral replacement, and individual matching level of joints is the bottleneck of restricting prosthesis replacement surgery. If we can design and produce corresponding individual artificial joints according to the patient's bone shape and bio-mechanical characteristics, there will be a significant impact on human health and medical treatment. In this paper, I complete the reconstruction process of the CT three-dimensional finite element model of femur, with the help of powerful image processing functions of medical imaging system MIMICS. I load force with the experimental data provided by the VIMS laboratory, analyze the biomechanical properties of femur and investigate the influence of anteversion angle parameter on mechanical properties.

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Challa, Abhinay, Jilani Latona, John Fraser, Michelle Spanevello, Gregory Scalia, Darryl Burstow e David Platts. "Mitral valve bio-prosthesis and annuloplasty thrombosis during extracorporeal membrane oxygenation: case series". European Heart Journal - Case Reports 4, n. 3 (24 aprile 2020): 1–6. http://dx.doi.org/10.1093/ehjcr/ytaa085.

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Abstract Background Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a well-recognized form of haemodynamic support for patients with refractory cardiogenic shock, who are unable to be weaned off cardiopulmonary bypass. Thrombosis or bleeding from cannula sites or surgical wounds are the leading cause of morbidity and mortality in these patients, and presents a delicate balance of anticoagulation during management of patients undergoing circulatory support. Case summary In this case series, we discuss three cases of patients undergoing mitral valve replacements or repair with thrombosis of their new bio-prosthesis in the immediate post-operative setting. All three patients were supported with VA-ECMO post-operatively, and thrombosis occurred despite anticoagulation. Discussion During extracorporeal membrane oxygenation, the reduced flow throughout the heart increases the risk of intra-cardiac thrombosis. This is of particular importance in the context of mitral valve replacements and repairs, where the bio-prosthesis is an additional risk factor for thrombosis. Our cases demonstrate the morbidity and mortality of such complications, with the likely aetiology being low transvalvular flow in a newly inserted valve combined with the pro-thrombotic state created by the VA-ECMO circuit.

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Joshi, Tanuj, Ravikant Sharma, Vinod Kumar Mittal e Vikas Gupta. "Comparative investigation and analysis of hip prosthesis for different bio-compatible alloys". Materials Today: Proceedings 43 (2021): 105–11. http://dx.doi.org/10.1016/j.matpr.2020.11.222.

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Trohalaki, Steven. "Bio Focus: Wireless PV retinal prosthesis shows promise for restoration of sight". MRS Bulletin 37, n. 9 (settembre 2012): 789–90. http://dx.doi.org/10.1557/mrs.2012.211.

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Hakky, T. S., E. V. Barrera, L. Ge, J. Wallen, R. E. Carrion e P. E. Perito. "221 An In-vivo a Bio-mechanical Comparison Between Inflatable Penile Prosthesis". Journal of Sexual Medicine 15, n. 2 (febbraio 2018): S74—S75. http://dx.doi.org/10.1016/j.jsxm.2017.11.180.

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LEMOYNE, ROBERT. "ADVANCES REGARDING POWERED PROSTHESIS FOR TRANSTIBIAL AMPUTATION". Journal of Mechanics in Medicine and Biology 15, n. 01 (febbraio 2015): 1530001. http://dx.doi.org/10.1142/s021951941530001x.

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The necessity for developing advanced prostheses are apparent in light of projections that the forecast for the number of people enduring amputation will double by the year 2050. The transtibial powered prosthesis that enables positive mechanical work about the ankle during the powered plantar flexion aspect of stance phase constitutes a paradigm shift in available transtibial prostheses. The objective of the review is to advocate the state of the art regarding the transtibial powered prosthesis. The historic origins of the prosthesis and motivations for amputation are clarified. The phases of gait and the compensatory mechanisms and asymmetries inherent with passive transtibial prostheses are described. The three general classes of transtibial prosthesis (passive, energy storage and return and powered prostheses) are defined. Subsystems that are integral to the powered prosthesis are explained, such as the series elastic actuator and control architecture. Gait analysis systems and their role for the test and evaluation of energy storage and return and powered prostheses are demonstrated. Future advanced concepts; such as the integration of titin into novel muscle models that account for force enhancement and force depression including their implications for cutting edge bio-inspired actuators are elucidated. The review accounts for the evolution of the prosthetic device with regards to the scope of transtibial amputation and assesses the current state-of-the-art.

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Astolfi, Víctor, Alberto Gómez-Menchero, José Vicente Ríos-Santos, Pedro Bullón, Francisco Galeote, Blanca Ríos-Carrasco, Beatriz Bullón de la Fuente e Mariano Herrero-Climent. "Influence of Removing or Leaving the Prosthesis after Regenerative Surgery in Peri-Implant Defects: Retrospective Study: 32 Clinical Cases with 2 to 8 Years of Follow-Up". International Journal of Environmental Research and Public Health 18, n. 2 (13 gennaio 2021): 645. http://dx.doi.org/10.3390/ijerph18020645.

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Purpose: The aim of this retrospective study was to compare the influence of removing or not removing a prosthesis after regenerative surgery on peri-implant defects. Methods: Two different groups were compared (Group 1: removing the prosthesis; Group 2: maintaining the prosthesis), analyzing radiographic bone filling (n = 32 implants) after regenerative treatment in periapical radiographs. The peri-implant defects were measured before and after regenerative treatment using Bio-Oss® (Geistlich Pharma, Wohhusen, Switzerland) and a reabsorbable collagen membrane (Jason®, Botis, Berlin, Germany), the healing period was two years after peri-implant regenerative surgery. Statistical analysis was performed, and a Chi square test was carried out. To determine the groups that made the difference, corrected standardized Haberman residuals were used, and previously a normality test had been applied; therefore, an ANOVA or Mann–Whitney U test was used for the crossover with the non-normal variables in Group 1 and Group 2. Results: The results obtained suggest that a regenerative procedure with xenograft, resorbable membrane, and detoxifying the implant surface with hydrogen peroxide form a reliable technique to achieve medium-term results, obtaining an average bone gain at a radiographic level of 2.84 mm (±1.78 mm) in patients whose prosthesis was not removed after peri-implant bone regenerative therapy and 2.18 mm (±1.41 mm) in patients whose prosthesis was removed during the healing period. Conclusions: There are no statistically significant differences in the response to treatment when removing or keeping the prosthesis after regenerative surgery in peri-implant defects.

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Calamote, Catarina, Isabel Carolina Coelho, António Sérgio Silva, José Luís Esteves, Luís Moreira, António Correia Pinto, María Cristina Manzanares-Céspedes e Tomás Escuín. "Comparison of the Masticatory Force (with 3D Models) of Complete Denture Base Acrylic Resins with Reline and Reinforcing Materials". Materials 14, n. 12 (15 giugno 2021): 3308. http://dx.doi.org/10.3390/ma14123308.

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The reinforcement of acrylic denture base remains problematic. Acrylic prosthesis fractures are commonly observed in prosthodontic practice and have not been reliably resolved. This study compared the resistance to masticatory force of acrylic bases of removable complete conventional prosthesis in 3D upper models. Forty acrylic base test specimens containing two types of reinforcement meshes (20 with glass fiber meshes (FIBER-FORCE®- Synca, Bio Composants MédicauxTM, Tullins, France), 20 with metal meshes (DENTAURUM®-Ispringen, Germany)), 20 with a conventional PMMA acrylic base (LUCITONE 199®-Dentsply Sirona, York, PA, USA), and 20 using a permanent soft reline material (MOLLOPLAST-B®-DETAX GmbH & Co. KG, Ettlingen, Germany) were tested—a total of 80 specimens. Half of the specimens were made for a low alveolar ridge and half for a high alveolar ridge. The data were analysed using one-way analysis of variance and Student’s t-test for independent test specimens. In the high-alveolar-ridge group, the prosthesis reinforced with the glass fiber mesh was the most resistant to fracture, while in the low-alveolar-ridge group, the non-reinforced prosthesis showed the highest resistance masticatory force. Prostheses with the permanent soft reline material showed the lowest resistance to fracture in both high and low-alveolar-ridge groups. The results show that the selection of the right reinforcement material for each clinical case, based on the height of the alveolar ridge, may help to prevent prosthesis fractures.

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R, Thanigaivel, Sofana K, Rajalakshmi A e Jishnuram P. "Modifiable Prosthetic Socket Using Air Pump Method". International Journal of Innovative Research in Advanced Engineering 11, n. 04 (5 aprile 2024): 354–60. http://dx.doi.org/10.26562/ijirae.2024.v1104.31.

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A prosthesis backup for a part of the body that may have been missing at birth or lost in an accident or through amputation. Prostheses are used to restore the normal functions of the missing body part. Traumatic injuries and different conditions have been set up as common causes of amputation. The need for prostheses in being patterns requires individual measuring and manufacturing of prostheses inclusively for every case. Also, Amputees find it delicate to fit and carry out their routine with a prosthetic duly heavy for them making it considered a burden. Quality of life, phantom branch pain, and the psycho-social impact of prosthetics are duly taken into account for the development of malleable prosthetic sockets. thus, preventing the individual manufacturing of prosthetic legs and the treatment is done and fixing of prosthesis becomes easier. A collaborative observation demands the design of a bio-compatible, feathery, and provident prosthesis to track normal mortal gait by barring phantom limb pain. This will improve the amputee's confidence to live a quality life in society.

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De Vivo Nicoloso, Luca Gabriele, Joshua Pelz, Herb Barrack e Falko Kuester. "Towards 3D printing of a monocoque transtibial prosthesis using a bio-inspired design workflow". Rapid Prototyping Journal 27, n. 11 (28 agosto 2021): 67–80. http://dx.doi.org/10.1108/rpj-06-2021-0136.

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Purpose There are over 40 million amputees globally with more than 185,000 Americans losing their limbs every year. For most of the world, prosthetic devices remain too expensive and uncomfortable. This paper aims to outline advancements made by a multidisciplinary research group, interested in advancing the restoration of human motion through accessible lower limb prostheses. Design/methodology/approach Customization, comfort and functionality are the most important metrics reported by prosthetists and patients. The work of this paper presents the design and manufacturing of a custom made, cost-effective and functional three-dimensional (3D) printed transtibial prosthesis monocoque design. The design of the prosthesis integrates 3D imaging, modelling and optimization techniques coupled with additive manufacturing. Findings The successful fabrication of a functional monocoque prosthesis through 3D printing indicates the workflow may be a solution to the worldwide accessibility crisis. The digital workflow developed in this work offers great potential for providing prosthetic devices to rural communities, which lack access to skilled prosthetic physicians. The authors found that using the workflow together with 3D printing, this study can create custom monocoque prostheses (Figure 16). These prostheses are comfortable, functional and properly aligned. In comparison with traditional prosthetic devices, the authors slowered the average cost, weight and time of production by 95%, 55% and 95%, respectively. Social implications This novel digital design and manufacturing workflow has the potential to democratize and globally proliferate access to prosthetic devices, which restore the patient’s mobility, quality of life and health. LIMBER’s toolbox can reach places where proper prosthetic and orthotic care is not available. The digital workflow reduces the cost of making custom devices by an order of magnitude, enabling broader reach, faster access and improved comfort. This is particularly important for children who grow quickly and need new devices every few months or years, timely access is both physically and psychologically important. Originality/value In this manuscript, the authors show the application of digital design techniques for fabricating prosthetic devices. The proposed workflow implements several advantageous changes and, most importantly, digitally blends the three components of a transtibial prosthesis into a single, 3D printable monocoque device. The development of a novel unibody transtibial device that is properly aligned and adjusted digitally, greatly reduces the number of visits an amputee must make to a clinic to have a certified prosthetist adjust and modify their prosthesis. The authors believe this novel workflow has the potential to ease the worldwide accessibility crisis for prostheses.

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Ozdemir, Zeynep, Valentin Craciun e Bahar Basim. "Self-protective Oxide Nano-Coatings for Enhanced Surface Biocompatibility of Titanium". MRS Proceedings 1806 (2015): 7–12. http://dx.doi.org/10.1557/opl.2015.378.

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ABSTRACTThe biocompatibility of an implant material depends on the bulk physical properties in addition to the surface properties. In biomedical engineering and industry Ti and Ti-alloys are very popular biological implant material for their bulk physical properties and strength to weight ratio resembling those of nature bone. It is possible to modify the surface properties of titanium for enhanced surface biocompatibility. The main objective of the this study is to engineer a smart Ti-based prosthesis surface by self induced chemically modified titanium oxide nano-film by the chemical mechanical polishing process (CMP). This new process applied on bio-implants aims at significantly reducing the out-diffusion of Ti and other metallic impurities from prosthesis in contact with body fluids and tissue and simultaneously enhancing the surface mechanical, chemical and biological properties. CMP technique enables the growth of a thicker and denser self-protective native oxide on Ti and Ti alloy samples, while simultaneously inducing a controlled surface roughness. It is demonstrated that the Ti based dental implants with self-protective oxide induced surfaces help minimize chemical and bacterial reactivity in addition to Ti ion dissolution while promoting their biocompatibility through surface patterning. The studied self-protective oxide films can also be utilized for many additional applications including bio-sensors.

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Shankar, Subramaniam, Rajavel Nithyaprakash e Balasubramaniam Rajasulochana Santhosh. "Short term tribological behavior of ceramic and polyethylene biomaterials for hip prosthesis". Materials Testing 63, n. 5 (1 maggio 2021): 470–73. http://dx.doi.org/10.1515/mt-2020-0080.

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Abstract Reduction in wear of artificial bio-implants results in the release of a lesser amount of wear particles into the blood stream. This paper focuses on analyzing the tribological behavior of ceramic and polyethylene bio-materials experimentally. Four different biomaterials namely Zirconia, Silicon Nitride, UHMWPE (ultra high molecular weight polyethylene) and PEEK (polyether ether ketone) are investigated for friction and wear coefficients using a pin on disc (PoD) tribometer. Alumina (Al2O3) is chosen as the disc material. Polyethylene based UHMWPE and PEEK are used as a pin material with the hemispherical end, while, Zirconia and Silicon Nitride ceramic materials are used in the form of spherical ball. 0.9 % NaCl (saline solution) is used as a lubricant medium. Zirconia showed a better reduction in friction and wear coefficient characteristics under lubrication conditions when compared with polyethylene and other ceramic materials. The estimated friction and wear coefficients would be helpful for surgeons and academicians to choose better wear-resistant bio-compatible materials for effectively design hip prosthesis. The present study compared the tribological behaviors of ceramic materials Si3N4 and ZrO2 and polyethylene materials PEEK and UHMWPE with a ceramic counterpart Al2O3 disc. In the lubrication case, ZrO2 showed a better reduction in friction and wear characteristics while in the dry case UHMWPE showed lesser wear characteristics.

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Zameer, Syed, e Mohamed Haneef. "Mechanical and Tribological Behavior of Bio Polymer Matrix Composites for Biomedical Prosthesis Applications". Advanced Materials Research 1105 (maggio 2015): 7–12. http://dx.doi.org/10.4028/www.scientific.net/amr.1105.7.

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Due to limitations of Conventional metallic biomaterials an attempt is made to develop a new hybrid polymer matrix composite for load bearing applications of Hip joints in the human body. Ultra high molecular weight polyethylene matrix material was blended with 50 wt% of short E-glass fibres and TiO2particles with varying percentage of reinforcement, using injection moulding machine. Fabricated composites specimens were subjected to tensile strength test, Fatigue test, SEM, Wear analysis test and In vivo Biocompatibility test to evaluate mechanical and tribological properties, required for bone joints load bearing applications. The maximum tensile strength of 41.5 MPa and young’s modulus of 7.5 GPa is obtained. The behavior of S-N curve obtained after the test is linear in nature, which leads to failure at 105cycles for the fabricated composite specimen. Also it reveals that fracture is due to brittle failure. The wear mechanism of composite specimen is, because of abrasion. Density of composite specimens was increased after dipping in the simulated body fluid solution.

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Orellana, Jaime, Teresa Palacios, Fernando Calle e José Ygnacio Pastor. "Bio-inspired redesign of a hip prosthesis stem for improving geometrical optimization time". Procedia Manufacturing 41 (2019): 121–28. http://dx.doi.org/10.1016/j.promfg.2019.07.037.

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Urbanski, Paul P. "Bio-Bentall: Do Not Sew the Valve Prosthesis Suture Ring to the Annulus". Annals of Thoracic Surgery 102, n. 1 (luglio 2016): 347–48. http://dx.doi.org/10.1016/j.athoracsur.2016.02.027.

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Amadji, Moussa, Hacene Ameddah e Hammoudi Mazouz. "Numerical Shape Optimization of Cervical Spine Disc Prosthesis Prodisc-C". Journal of Biomimetics, Biomaterials and Biomedical Engineering 36 (marzo 2018): 56–69. http://dx.doi.org/10.4028/www.scientific.net/jbbbe.36.56.

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Various ball and socket-type designs of cervical artificial discs are in use or under investigation. All these disc designs claim to restore the normal kinematics of the cervical spine. In this study, we are interested in the cervical prosthesis, which concerns the most sensitive part of the human body, given the movements generated by the head. The goal of this work is to minimize the constraints by numerical shape optimization in the prodisc-C cervical spine prosthesis in order to improve performance and bio-functionality as well as patient relief. Prodisc-C cervical spine prosthesis consists of two cobalt chromium alloy plates and a fixed nucleus. Ultra-high molecular weight polyethylene, on each plate there is a keel to stabilize the prosthesis; this prosthesis allows thee degrees of freedom in rotation. To achieve this goal, a static study was carried out to determine the constraint concentrations on the different components of the prosthesis. Based on the biomechanical behaviour of the spine discs, we totally fixed the lower metal plate; a vertical load of 73.6 N to simulate the weight of the head was applied to the superior metallic endplate. After a static study on this prosthesis, using a finite element model, we noticed that the concentration of the Von-Mises stress is concentrated on the peripheral edge core and the concave articulating surface of the superior metallic endplate the numerical. We use the module optimization for 3D SolidWorks for optimize our design, based on the criteria of minimizing stress value. Shape optimization concluded to minimize the equivalent stress value on both joint surface (concave and convex) from 11.3 MPa to 9.1MPa corresponding to a percentage decrease of 19.4% from the original geometry. We conclude that despite the fact that maximum Von Mises stresses are higher in the case of the dynamic load, remains that they are weak. Which is an advantage for the durability of the prosthesis and-also for the bone, because a low stress concentration on the prosthesis will reduce stress concentration generated by the implant on the bone, therefore its risk of fracture reduces.

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Singh, Devendra Kumar, e Rajesh Kumar Verma. "A critical review on ultra high molecular weight polyethylene (UHMWPE) for prosthesis and implant functions". E3S Web of Conferences 309 (2021): 01018. http://dx.doi.org/10.1051/e3sconf/202130901018.

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Polymer composites benefit joint prostheses and implants in biomaterials due to their high strength, reliability, and elasticity modules. The addition of nanoparticles into the polymer-based matrix has effectively demonstrated up-grading wear resistance and implant strength improvement. Therefore, due to the elevated surface area and immense properties, considerable attention has been paid to research in integrating nanoparticles for a wide variety of functions. The UHMWPE is extensively used to develop prosthesis and orthopedic operations due to exceptional mechanical and biocompatible features. The various research studies revealed the fabrication of bio nanocomposites with the polymer matrix possesses superior biocompatibility and durability. This paper presents a critical review of UHMWPE for the latest advancement in polymeric implants by adding different nanoparticles. Another exciting aspect of the proposed work is the addition of different organic (carbon, polymeric) and inorganic (metallic and metal oxides) nanoparticles to develop bio-nano composites. An effort has been made to highlight the exceptional features of modified UHMWPE by supplementing nanofillers for biomedical functions.

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Mebarki, Salah, Benaoumeur Aour, Malachanne Etienne, Franck Jourdan, Abdel Hakem Belaghit e Abdelkader Gasmi. "Numerical Study of the Biomechanical Behaviour of the Different Implantation Methods of the Reverse Shoulder Replacement". Journal of Biomimetics, Biomaterials and Biomedical Engineering 43 (novembre 2019): 54–66. http://dx.doi.org/10.4028/www.scientific.net/jbbbe.43.54.

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Despite the widespread use of reverse total shoulder arthroplasty, there is still a problem of conflict between the polyethylene cup of the prosthesis and the scapula, which over time causes the phenomenon of notching. In order to circumvent this problem correctly, several innovations have been proposed regard to the implementation method. In this context, the aim of this work is to study the biomechanical behavior of new implantation methods using different glenoid configurations in order to avoid the notching phenomenon between the cup and the scapula. The study was performed using virtual prototypes of the shoulder prosthesis assembly. Using CT scan images, three-dimensional models of shoulder bones were reconstructed. The implantation of the prosthesis in the three-dimensional model was performed in collaboration with an experienced surgeon from the Caduceus Clinic (Oran, Algeria). The numerical models were imported to finite element calculation software. After the validation of the numerical model using the literature results, we assessed the biomechanical behavior of four implantation methods under the same boundary conditions and abduction movements. From the obtained results, it was found that among the proposed methods, the BIO-SR lateralization method offers significant biomechanical advantages in terms of the forces applied to the glenoid during the abduction movement.

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D’Alessio, Andrea, Danilo Verdichizzo, Fabio Falconieri, Amar Keiralla, Joanna Abramik, Georgios Kasimis e George Krasopoulos. "Thrombotic Thrombocytopenic Purpura Following Aortic Valve Replacement with St. Jude Medical Trifecta Bio-Prosthesis". Cardiology Research 9, n. 6 (2018): 392–94. http://dx.doi.org/10.14740/cr780w.

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Cuisset, T., N. Melikian, G. Sarno, M. Hamilos e M. Goethals. "Factitious tricuspid bio-prosthesis stenosis: An unusual presentation of a left-to-right shunt". International Journal of Cardiology 127, n. 1 (giugno 2008): e16-e17. http://dx.doi.org/10.1016/j.ijcard.2007.01.071.

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Laing, J. H. E., e R. Sanders. "The Misti Gold bio-oncotic gel filled breast prosthesis: an acceptable alternative to silicone?" British Journal of Plastic Surgery 46, n. 3 (1993): 240–42. http://dx.doi.org/10.1016/0007-1226(93)90175-b.

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Saucedo-Orozco, Huitzilihuitl, Jesus Vargas-Barron, Ricardo Márquez-Velazco, Julio Iván Farjat-Pasos, Karla Susana Martinez-Zavala, Valentin Jiménez-Rojas, Sergio Andres Criales-Vera et al. "Bioprosthesis in aortic valve replacement: long-term inflammatory response and functionality". Open Heart 9, n. 2 (agosto 2022): e002065. http://dx.doi.org/10.1136/openhrt-2022-002065.

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BackgroundThe evaluation of long-term inflammatory response and function in postoperative patients with aortic valve replacement (AVR) deserves special analysis because it is important to try to prevent reoperation and improve durability and functionality of the prostheses. It is our objectiveMethodsIn this study, we included a cohort of patients with aortic valve damage treated by AVR with mechanical prosthesis, bio prosthesis and we included a control group.ResultsWe found that IL-4 and osteopontin levels were higher in patients with mechanical vs biological prostheses (p=0.01 and p=0.04, respectively), osteoprotegerin (OPG) levels were decreased (p=0.01), women had lower levels of ET-1 and IL-6, (p=0.02) (p=0.04), respectively. Patients older than 60 years had decreased levels of IL-1ß p<0.001) and a higher concentration of IL-4 p<0.05). IL-1ß, OPG and TNFα were higher in patients with less than 5 years of evolution vs more than 10 years (p=0.004, p=0.02 and p=0.03, respectively). Factors such as age, gender, prosthetic and elevated IL-1B and ET-1 levels are associated with valve dysfunction prosthetic. These results indicate that the inflammatory involvement present prior to valve replacement may be perpetuated by various factors in the long term.ConclusionsThe findings provide us with the opportunity to effectively treat patients with AVR in the postoperative period, which could prolong the functionality of the bio prostheses.Trial registration numberNCT04557345.

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Quintessenza, James A. "Polytetrafluoroethylene pulmonary valve conduit implantation for chronic pulmonary insufficiency". Cardiology in the Young 24, n. 6 (dicembre 2014): 1101–3. http://dx.doi.org/10.1017/s1047951114002200.

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AbstractPulmonary valve replacement in patients with congenital cardiac disease is now being performed with more liberal indications in light of the data that chronic pulmonary insufficiency is not a benign lesion. The beneficial effects of valve replacement with low operative mortality and morbidity support this approach. Many options exist for a pulmonary valve prosthesis, which underscores the fact that there is no ideal valve available. Our efforts are focussed around a synthetic valve that avoids the bio-degeneration of a bio-prosthesis and avoids the need for life-long coumadin. We developed a bicuspid (bileaflet) polytetrafluoroethylene valve design, which has now gone through three major revisions in >200 patients over 14 years. We began the experience utilising a polytetrafluoroethylene hand-sewn bicuspid valve in the right ventricular outflow tract, initially using 0.6 mm and more recently 0.1 mm polytetrafluoroethylene. The 0.1 mm thickness material functions well as a leaflet, maintaining a relatively thin and flexible nature. It does not calcify or initiate thromboses at least for the first several years. We identified issues with dehiscence of the leaflet from the right ventricular outflow tract muscle, especially in the larger, potentially expansive right ventricular outflow tracts, and this prompted our latest design change to place the valve within a polytetrafluoroethylene tube. This current version of the polytetrafluoroethylene valve conduit has excellent short-to-intermediate-term function. Further follow-up is necessary to determine late durability and life-long valve-related procedural risk for our patients.

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Kosovskikh, E. А., K. А. Petlin, E. V. Lelik e Boris N. Kozlov. "Effect of Implantation of a new Domestic Prosthesis in the Aortic Position on the Quality of Life of Patients With Degenerative Aortic Stenose, Survival Assessment and Development of Complications 1 Year Post-Surgery". Kardiologiia 63, n. 6 (30 giugno 2023): 45–51. http://dx.doi.org/10.18087/cardio.2023.6.n1981.

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Aim To evaluate quality of life (QoL), general survival, and development of complications in patents one year after surgical aortic valve (AV) replacement with a MedInzh-BIO xenopericardial carcass prosthesis.Material and methods Degenerative AV disease is one of the most common cardiovascular diseases that gives place only to ischemic heart disease. Surgical correction of the AV defect should be aimed not only at hemodynamic outcomes but also at improvement of QoL. This study included 91 patients (48 women and 43 men), who were implanted with a MedInzh-BIO biological xenopericardial prosthesis in aortic position from January 2017 through March 2020. Mean age of patients was 69.96±4.4 years. QoL was evaluated with a standard SF-36 questionnaire. Also, survival and complications were analyzed one year after surgery.Results Data analysis before and one year after surgery showed a significant improvement of QoL. Postoperative one-year survival was 95.4 %, and major valve-associated complications were absent in 94.5% of cases. During one year, four patients died after 1, 6, 8, and 10 months of follow-up, respectively.Conclusion The improvement of QoL following the AV replacement with a novel xenopericardial carcass prosthesis with the “easy change” system indicates the clinical and functional effectiveness of the used method. The results of the study demonstrated improvements of both the physical health component and the subjective emotional assessment. Postoperative one-year survival was 95.4 %, and major valve-associated complications were absent in 94.5% of cases.

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Pareek, Mitali, e Brahmansh Kaushik. "Artificial intelligence in prosthodontics: a scoping review on current applications and future possibilities". International Journal of Advances in Medicine 9, n. 3 (23 febbraio 2022): 367. http://dx.doi.org/10.18203/2349-3933.ijam20220444.

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Artificial intelligence (AI) is the data-driven disruptive technology of modern times. AI is reforming every field from space science to dentistry. Bio-medical provides various advantages over conventional diagnosis, treatment planning, patient documentation and management. Every field is implementing AI for the ease of both doctors and patients. In this present work, the review was done for the implementation of AI in prosthodontics. Prosthetic dentistry or prosthodontics is one of the branches of dentistry, mainly deals with replacement and rehabilitation of missing teeth with the help of fixed and removable prosthesis or with biocompatible substitutes like implants. In addition, it also helps to restore proper soft and hard tissues of the mouth, thereby improving the overall health status of the oral cavity. The following review highlighted the present-day technology of AI in dental prosthetics and its efficacy in diagnosing and constructing more patient-specific prosthesis. In conclusion, it is seen that AI is twin fold technology having both applications and limitations in dentistry.

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Kumar, Mandeep, Abhishek Avasthi, Shivani Khanna, Karanveer Singh, Harleen Chhina e Natasha Bathla. "A literature review on various luting cements used in dentistry". IP Annals of Prosthodontics and Restorative Dentistry 8, n. 4 (15 novembre 2022): 199–202. http://dx.doi.org/10.18231/j.aprd.2022.041.

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The success rate of the given fixed partial denture and the longevity of the fixed partial denture is depend on the tooth preparation and the usage of the luting cement under the fixed partial denture prosthesis. Luting cement plays an important role in maintaining or securing the fixed partial denture prosthesis in the cemented position. Luting cement should be bio compatible, it should be non-irritating to the underlying tooth structure and non-irritating to the pulp, it should maintain the adequate marginal seal. In recent days so many newer luting cements has been introduced in to the dentistry, that are claiming for good as well as better clinical performance from the existing cements in the terms of improved and better characteristic properties. The different cements which can be used as luting cements are glass ionomer cements, zinc phosphate, zinc poly carboxylate, zinc oxide eugenol, newer cements like resin modified glass ionomer cements, compomers and resin cements.

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Lukyanov, Evgeny, Denis Khashev e Aleksey Lysenko. "Modelling the dynamics of the force interaction between the prosthetic sleeve and the patient's hand". E3S Web of Conferences 420 (2023): 05001. http://dx.doi.org/10.1051/e3sconf/202342005001.

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The article deals with the design processes of modern prostheses of the upper limbs, including the prosthetic sleeve. It has been established that the applied design methods and manufacturing technologies for prosthetic sleeves do not take into account the elastic-rigidity characteristics of human hand tissues interacting with the prosthesis. The review made it possible to determine the existing problems in the field of creating prosthetic sleeves. The authors considered the issues of using data from the results of the experiment to reconstruct the forces that arise between the patient's stump and the cult-receiving sleeve. A feature of the work is the study of the results of the experiment modelling the dynamics of power loads. The findings allow us to supplement the Bio Sculptor patient stump analysis system. The nature of the force interactions of the prosthesis and the human hand in the process of performing movements is considered on the basis of a virtual model.

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Vola, Marco, Juan Pablo Maureira, Vito Giovanni Ruggieri, Jean-François Fuzellier, Salvatore Campisi, Jean-Pierre Favre, Antoine Gerbay e Thierry A. Folliguet. "Proof of Concept of an Endoscopic Sutureless Valve Sizer". Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery 11, n. 5 (settembre 2016): 337–41. http://dx.doi.org/10.1097/imi.0000000000000313.

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Objective In this paper, we present an endoscopic expandable sizer conceived to allow thoracoscopic aortic valve replacement with a sutureless prosthesis using a dynamic sizing of the aortic annulus. Methods Ten aortic torsos were prepared using a five-trocar thoracoscopic setting. Once the aortotomy was performed and the aortic valve leaflets removed, the technical feasibility of the endoscopic sizing (introduction into the trocar, expansion into the aortic annulus, determination of the valve size, and retraction) with the device was assessed. In case of successful thoracoscopic sizing, endoscopic implantation of a sutureless valve (five LivaNova Perceval prosthesis and five Medtronic 3f Enable bioprosthesis) was performed. Before ascending aorta closure, we assessed the appropriate sealing of the bioprosthesis in the native annulus with camera visualization and a nerve hook inspection. Results All the 10 endoscopic sizings were technically feasible. The scheduled aortic sutureless valve implantations were successfully performed. In all cases, fitting and placement of the sutureless bio-prosthesis in the flaccid heart was satisfactory, with no paraprosthetic leakage detectable by the nerve hook. Conclusions The use of the endoscopic expandable sizer is technically possible. In this early-stage test in the flaccid heart, selection of the valve size was satisfactory during thoracoscopic sutureless aortic bioprosthesis implantation. Further laboratory evaluation with fluid dynamics (aortic root pressurization) will be performed before a clinical study is started.

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Feyrer, Richard, Minh Tuan Nguyen, Agrita Brambate, Susanne Koelsch e Thomas Lenz. "Self Made Bio-conduit using the Edwards INSPIRIS RESILIA: A Modern Alternative to Mechanical Prosthesis". Structural Heart 4, sup1 (13 febbraio 2020): 17. http://dx.doi.org/10.1080/24748706.2020.1713676.

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Kumar, Vishnu Senthil. "Fracture neck of femur in severe coxa-vara – Challenging management in an Achondroplasia patient". IP International Journal of Orthopaedic Rheumatology 8, n. 1 (15 luglio 2022): 29–32. http://dx.doi.org/10.18231/j.ijor.2022.007.

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Achondroplasia is a skeletal dysplasia of autosomal dominant inheritance. Fibroblast growth factor receptor 3 mutation at p16.3 locus of chromosome 4 leads to inhibition of sub-chondral growth. Middle aged achondroplastic patient with left fracture neck of femur following a fall of heavy object. It was a challenging case because of coxa-vara and meticulous templating is needed. 38 year old male sustained fracture neck of left femur in severe coxa-vara. Closed reduction with 16 mm partially threaded cannulated cancellous screw perpendicular to native neck- shaft angle. At regular follow up, mild lysis was seen around the screw and implant removal was done. Now with neck of femur non-union, walking full weight bearing with walker. The future course included excision arthroplasty or custom made prosthesis. Achrondroplasia characterised by defects in en-chondral bone formation leading to retarded cartilage growth. Literature search on peri-articular fracture management showed peadiatric disatal femur fracture fixed with percutaneous screws. In adult, neck of femur fracture is managed by percutaneous screw, DHS or prosthesis. Due to altered geometry of proximal femur DHS and Prosthesis was deferred.Early failure of CC screws in our case is due to perpendicular placement of screws which increased strain due to altered bio-mechanics. Achondroplastic dwarfs live a normal life. They are prone to peri-articular fractures because of anatomical variations. We wanted to highlight the difficulties and importance of pre-op planning and implant choice of fracture fixation in an adult achondroplasia patient.

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Thaís Duarte Brasileiro, Camilla, Fabianne Maria do Vale Veras Marques, Cristiano da Silva Sena, Malvina De Souza Pereira, Ricardo Ferreira Pedrosa, Claudia Elizabete Pereira de Lima e André Ferraz Goiana Leal. "PROSTHETIC STOMATITIS". Health and Society 2, n. 04 (2 settembre 2022): 149–70. http://dx.doi.org/10.51249/hs.v2i04.900.

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Introduction: Candidiasis or Candidosis are designated names designated as infectious names for fungi of the genus Candida spp., which establish a commensal relationship with the immune system when the system is depressed or by some pathogenic infections. As proposals of oral candidiasis can be hyperplastic in primary and secondary cited by the following types: pseudoplastic, erythematous, pseudomembrane, erythematous; there is a category called “lesions also associated with Candida spp.”, which includes denture stomatitis (PE). Knowing the relationship between the development of the disease and the use of dental prosthesis, the present work aims to carry out a literature review on the subject. Methodology: This is a descriptive work with a qualitative aspect of literature review, where they were used as sources of scientific and scientific research. The search platforms used were PubMed, Scielo and the Virtual Health Library. Results and discussion: The presence of devices or devices such as appliances or orthodontic appliances can provoke or modify the best of the microbiota, due to the physical-bio oral environment. In addition, the prosthesis is often related to the use of oral prostheses, such as traumatic ulcers, mucogingival hyperplasia and many oral candidiasis. One of the causes of PE is the proper use of the prosthesis, which, associated with poor hygiene, can be a factor that potentiates the disease; therefore, it is extremely important that the patient is advised about the risk of developing the condition and how to avoid it. Final considerations: The relationship between the use of dental prosthesis and the development of oral candidiasis is well related in the literature. Therefore, dental professionals must take care of patients who use the device for disease care, seeking to improve the possibility of disease development.

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Marchese, Alfredo, Giuseppe Tarantini, Antonio Tito e Antonio Colombo. "Transcatheter aortic valve-in-valve post-dilatation as an overlooked risk factor of delayed coronary obstruction: a case report". European Heart Journal - Case Reports 4, n. 5 (1 ottobre 2020): 1–6. http://dx.doi.org/10.1093/ehjcr/ytaa368.

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Abstract Background The risk of coronary obstruction during transcatheter aortic valve-in-valve replacement (VIV-TAVR) in patients deemed at high risk for surgical re-intervention is still a concerning issue. Case summary A 78-year-old woman with a past medical history of hypertension, chronic kidney disease, and rheumatoid arthritis was referred for a symptomatic and severely stenotic surgical Mitroflow n.21 bio-prosthesis and was subsequently recommended for a VIV procedure. Multiple anatomical risk factors for coronary occlusion required a pre-emptive coronary chimney stenting protection. The implantation of an Evolut-R 23 mm valve resulted in a gradient of 21 mmHg thus, a post-dilatation with an 18 mm balloon was performed. Both electrocardiographic and haemodynamic parameters remained excellent, however, a hazardous leaflet dislodgment became evident. Regardless, a prophylactic chimney stenting was performed because of the operator’s perceived high risk of late coronary occlusion. Discussion The implantation of transcatheter valves inside failed surgically implanted aortic bio-prosthesis is broadly recognized as a safe and less-invasive alternative to repeated high-risk surgery. Although procedural success is achieved in the great majority of patients, this therapy may be jeopardized by rare but serious complications such as impending or established acute coronary occlusion. Several specific anatomical and procedural risk factors have been identified and primary coronary prevention strategies are often mandatory when they arise. Valve-in-valve post-dilation has been overlooked in its role as an additional risk factor of late coronary obstruction. Therefore, chimney stenting, performed after balloon post-dilation to prevent delayed coronary obstruction, even if the acute coronary event does not occur intra-procedurally, is strongly advisable.

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Kannan, Ruben Y., Sandip Sarkar, Jalaledin Mirzay-Razaz e Alexander M. Seifalian. "New vessels: Vascular tissue engineering". Biochemist 29, n. 1 (1 febbraio 2007): 12–15. http://dx.doi.org/10.1042/bio02901012.

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The use of vascular bypass grafts in patients is not new. The high prevalence of atherosclerosis has seen them being used in the treatment of some of the 800 000 cases of myocardial infarction in the UK. So, is there a need for tissue-engineered blood vessels if there is a functional prosthetic alternative? While this may hold true for vessels with high-blood-flow rates1, the patency rates of poly(ethylene terephthalate) (Dacron®) and expanded polytetrafluoroethylene (ePTFE) grafts are less satisfactory at lower flow rates. Given the limitations with synthetic materials alone, a biological or bio-hybrid vascular prosthesis could provide us with the ideal blood-vessel substitute.

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Mebarki, Salah, Benaoumeur Aour, Franck Jourdan, Etienne Malachanne e Abdel Belaghit. "A Study of the Biomechanical Behavior of the Implantation Method of Inverted Shoulder Prosthesis (BIO–RSA) under Different Abduction Movements". Bioengineering 6, n. 1 (19 febbraio 2019): 19. http://dx.doi.org/10.3390/bioengineering6010019.

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Abstract (sommario):

The shoulder is the most mobile joint of the human body, but it is very fragile; several pathologies, and especially muscular degenerations in the elderly, can affect its stability. These are more commonly called rotator cuff fractures. In the case of this type of pathology, the mobility of the shoulder decreases and pain appears. In order to restore mobility and reduce pain, implantation of an inverted shoulder prosthesis is recommended. Unfortunately, over time a notch phenomenon has been observed. In the lower position of the arm, part of the implant comes into contact with the scapula and therefore causes deterioration of the bone. Among the solutions adopted is the lateralized method with bone grafting. However, a main disadvantage of this method concerns the reconstruction of the graft in the case of prosthesis revision. In this context, the aim of the present work was to reconstruct the shoulder joint in 3D in order to obtain a bio-faithful geometry, and then study the behavior of different types of biomaterials that can replace bone grafting. To this end, three arm abduction motions were examined for three individuals. From the results obtained, it appears that grafts in ultra-high molecular weight polyethylene (UHMWPE) exhibit a behavior closer to that of bones.

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Jolicoeur, M. E., S. Banai, P. Garceau, R. Cartier, M. Schwartz, S. Biner, J. Tanguay, S. Verheye, C. J. White e E. Edelman. "569 TIARA - a Novel Catheter-Based Mitral Valve Bio-Prosthesis: Initial Experiments and Pre-Clinical Results". Canadian Journal of Cardiology 28, n. 5 (settembre 2012): S311—S312. http://dx.doi.org/10.1016/j.cjca.2012.07.517.

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Banai, Shmuel, Marc Jolicoeur, Jean-François Tanguay, Stefan Verheye, Christopher White e Elazer Edelman. "TCT-107 TIARA - A Novel Catheter-Based Mitral Valve Bio-Prosthesis Short Term Pre-Clinical Results". Journal of the American College of Cardiology 60, n. 17 (ottobre 2012): B33. http://dx.doi.org/10.1016/j.jacc.2012.08.124.

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