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Park, Soonchan, Jae-Hyuk Kim, Jae Kyun Kwak, Hye Jin Baek, Bo Hyun Kim, Dong-Geun Lee, Deok Hee Lee, Jong Sung Kim e Dae Chul Suh. "Intracranial Stenting for Severe Symptomatic Stenosis: Self-Expandable versus Balloon-Expandable Stents". Interventional Neuroradiology 19, n. 3 (settembre 2013): 276–82. http://dx.doi.org/10.1177/159101991301900303.
Testo completoAbstract (sommario):
Intracranial atherosclerosis against optimal medical treatment requires reperfusion therapy to improve the clinical outcome. We compared outcomes between self-expandable stent (SES) and/ or balloon-expandable stent (BES) and present the potential advantages of using each stent. During the same time frame before and after Wingspan introduction to our institute, 115 consecutive patients underwent intracranial stenting for symptomatic severe intracranial stenosis against optimal medical treatment using BES alone (n = 71) vs. BES or SES (n = 44). We analyzed 15 factors including outcome related to an adverse event (AE), modified Rankin Scale (mRS) and restenosis at six months and retrospectively compared the potential advantages of using each stent. BES or SES groups had a significantly lower AE rate (2.3%) than the BES only group (14%) (P = 0.049) revealing mRS of ≤ 2 in all patients at six months compared to 93% of the patients in the BES group. Analysis of BES or SES subgroups revealed that BES was associated with less residual stenosis after stenting than SES (18 vs. 32%; P < 0.001). Both SES and BES can improve the clinical outcome of intracranial stenting especially with a selective choice of SES or BES. Further study is needed to analyse the difference in long-term outcome and the restenosis rate between SES and BES.
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Aditianingsih, Dita, Anne S. Djaja e Yohanes W. H. George. "The effect of balanced electrolyte solution versus normal saline in the prevention of hyperchloremic metabolic acidosis in diabetic ketoacidosis patients: a randomized controlled trial". Medical Journal of Indonesia 26, n. 2 (18 agosto 2017): 134–40. http://dx.doi.org/10.13181/mji.v26i2.1542.
Testo completoAbstract (sommario):
Background: In resuscitation, normal saline could cause hyperchloremic metabolic acidosis, while balanced electrolyte solution is a crystalloid fluid resembling blood plasma with lower chloride content. This study compared the effect of normal saline and balanced electrolyte solution Ringerfundin (BES) as the resuscitation fluid in diabetic ketoacidosis (DKA) patients. Parameters applied in this study were standard base excess (SBE) as resuscitation’s result indicator and strong ion difference (SID) to measure chloride’s influence in developing hyperchloremic acidosis.Methods: A prospective, randomized, single blind controlled trial was conducted at the Emergency Department of Cipto Mangunkusumo Hospital. Thirty subjects with blood sugar >250 mg/dl, arterial pH <7.35 mg/dl, and positive blood ketone were randomly allocated to receive either normal saline (NS) or RingerfundinÒ (BES) as the standardized resuscitation protocol. Data analysis was performed using the unpaired T-test and the Mann Whitney test to compare the SBE and the SID means between both groups. Additional parameters were the level of consciousness, blood sugar level, vital signs, blood gas analysis, lactate, electrolyte, and blood ketone.Results: The mean SID in the BES group was significantly greater than the NS group of all measurements (p<0.05). The BES group had significantly higher mean SBE compared to the NS group at 18 hours (-4.88±5.69 vs -9.68±5.64; p=0.009), 24 hours (-3.99±4.27 vs -8.7±5.35; p=0.023), and 48 hours (-4.06±4.11 vs -7.01±5.46; p=0.009). BES resulted in non-significant higher delta SBE and SID than NS. Additional parameters were not different between both groups.Conclusion: This study showed that fluid resuscitation of DKA patients with BES resulted in slightly but not significantly higher mean actual SBE and SID than NS. suggesting that BES as an alternative fluid resuscitation to prevent hyperchloremic acidosis in diabetic ketoacidosis patients was not superior to NS.
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Tsaniyah, Rohmatus, e M. Nurul Huda. "Exploring Nexus Between Spiritual Intelligence and Leadership Success of BES JA’s President". Journal Intellectual Sufism Research (JISR) 3, n. 1 (24 novembre 2020): 45–49. http://dx.doi.org/10.52032/jisr.v3i1.83.
Testo completoAbstract (sommario):
Abstract. Leadership is the ability to influence a group towards achieving goals. A leadership certainly has a benchmark of leadership success which will further be referred to as an indicator of leadership success, which is certainly related to the course of the organization during his leadership. The success of leadership is caused by several factors, one of which is spiritual intelligence. The purpose of this study is to describe the spiritual intelligence of President BES JA, the success of President BES JA's leadership, and the relationship between the two. This research is a descriptive type of research with a qualitative approach. The subjects of this study were the three old Presidents of BES JA. The results of this study are that the President of BES JA has a good relationship with Allah SWT and relations with fellow human beings and their leadership at BES JA in each period is considered quite successful in developing work programs, formulation and implementation of the regulations of the cottage, and the way BES JA stewardship wheels. And there is a link between spiritual intelligence and leadership success.
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Walter, Daisy, Maarten van den Berg, Meike Hirdes, Frank Vleggaar, Alessandro Repici, Pierre Deprez, Bartolomé Viedma et al. "Dilation or biodegradable stent placement for recurrent benign esophageal strictures: a randomized controlled trial". Endoscopy 50, n. 12 (8 giugno 2018): 1146–55. http://dx.doi.org/10.1055/a-0602-4169.
Testo completoAbstract (sommario):
Abstract Background Dilation is the standard of care for recurrent benign esophageal strictures (BES). Biodegradable stents may prolong the effect of dilation and reduce recurrences. Efficacy and safety of dilation and biodegradable stent placement early in the treatment algorithm of recurrent BES were compared. Methods This multicenter, randomized study enrolled patients with BES treated with previous dilations to ≥ 16 mm. The primary end point was number of repeat endoscopic dilations for recurrent stricture within 3 and 6 months. Secondary outcomes through 12 months included safety, time to first dilation for recurrent stricture, dysphagia, and level of activity. Results At 3 months, the biodegradable stent group (n = 32) underwent significantly fewer endoscopic dilations for recurrent stricture compared with the dilation group (n = 34; P < 0.001). By 6 months, the groups were similar. The number of patients experiencing adverse events was similar between the groups. Two patients in the biodegradable stent group died after developing tracheoesophageal fistulas at 95 and 96 days post-placement; no deaths were attributed to the stent. Median time to first dilation of recurrent stricture for the biodegradable stent group was significantly longer (106 vs. 41.5 days; P = 0.003). Dysphagia scores improved for both groups. Patients in the biodegradable stent group had a significantly higher level of activity through 12 months (P < 0.001). Conclusion Biodegradable stent placement is associated with temporary reduction in number of repeat dilations and prolonged time to recurrent dysphagia compared with dilation. Additional studies are needed to better define the exact role of biodegradable stent placement to treat recurrent BES.
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Park, Ji Young, Seung-Woon Rha, Yung-Kyun Noh, Byoung Geol Choi, Ji Yeon Hong, Jae-Woong Choi, Sung Kee Ryu, Sung-Hun Park, Yong Hoon Kim e Myung Ho Jeong. "Real-World Three-Year Clinical Outcomes of Biolimus-Eluting Stents versus Other Contemporary Drug-Eluting Stents in Patients with Acute Myocardial Infarction Patients: Data from the Korea Acute Myocardial Infarction Registry (KAMIR)". Journal of Interventional Cardiology 2021 (20 luglio 2021): 1–7. http://dx.doi.org/10.1155/2021/6698582.
Testo completoAbstract (sommario):
Introduction. Biolimus-eluting stents (BES) are known to be superior to bare-metal stents. This study aims to evaluate the safety and efficacy of BES compared to other drug-eluting stents (DES) based on big data from the Korea Acute Myocardial Infarction Registry (KAMIR). Methods. The study analyzed a total of 9,759 acute myocardial infarction (AMI) patients who underwent percutaneous coronary intervention (PCI) with DES. Total death, cardiac death, recurrent MI, revascularization, stent thrombosis, target lesion failure (TLF, composite of cardiac death, recurrent myocardial infarction (MI), and target lesion revascularization), and major adverse cardiac events (MACE, composite of total death, recurrent MI, and revascularization) were analyzed in patients with AMI up to three years. Study populations were divided into BES (n = 2,020), everolimus-eluting stents (EES, n = 5,293), and zotarolimus-eluting stents (ZES, n = 2,446) groups. Results. To adjust baseline potential confounders, an inverse probability weighting (IPTW) analysis was performed. After IPTW, at three years, total death (7.2%, 8.6%, and 9.5%, P < 0.001 ), cardiac death (4.1%, 5.3%, and 6.6%, P < 0.001 ), recurrent MI (1.6%, 2.6%, and 3.2%, P < 0.001 ), TLF (6.5%, 8.1%, and 9.1%, P < 0.001 ), and MACE (15.8%, 17.5%, and 18.2%, P < 0.001 ) were lowest in the BES group compared with the other DES groups in AMI patients. During the 3-year clinical follow-up, the BES group showed better outcomes of MACE (hazard ratio (HR), 0.773; 95% confidence interval (CI), 0.676–0.884; P < 0.001 ), TLF (HR, 0.659; 95% CI, 0.538–0.808; P < 0.001 ), total death (HR, 0.687; 95% CI, 0.566–0.835; P < 0.001 ), and cardiac death (HR,0.593; 95% CI, 0.462–0.541; P < 0.001 ) than the EES groups. Conclusions. In this study, BES was superior to EES or ZES in reducing total death, cardiac death, TLF, and MACE in AMI patients.
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Nicholls, Wendy, Craig Harper, Linda A. Selvey, Suzanne Robinson, Gerald Hartig e Martin Persson. "Body Esteem in a Western Australian Cleft Lip and/or Palate Cohort Across 3 Age Groups". Cleft Palate-Craniofacial Journal 55, n. 4 (14 dicembre 2017): 487–98. http://dx.doi.org/10.1177/1055665617730362.
Testo completoAbstract (sommario):
Objectives: To determine if patients with cleft lip and/or palate (CL/P) from a Western Australian (WA) cohort were more dissatisfied with their body esteem than a normative non-cleft cohort, and identify demographic variables that may have significant associations with body esteem. Design: Questionnaire study using the Body-Esteem Scale (BES) and Cleft Research Questionnaire (CRQ). Participants: Self-selected participants from a Western Australian CL/P population across 3 age groups (n=359). Main outcome measures: The BES is comprised of 3 factors: BE-Appearance, BE-Weight and BE-Attribution. Study mean BES factor scores were compared to normative non-cleft scores. Regression analysis was used to determine significant associations within each age group between BES factor scores and CRQ variables of: gender, self-reported body weight category, cleft type and importance of facial appearance rating. Results: Study mean BE-Attribution scores were significantly lower than the normative scores and significantly lower than the mean BE-Appearance and BE-Weight factor scores within the same age groups of this study. Having a cleft type of lip and palate, being overweight, and placing a high importance on facial appearance had significant negative associations with BES scores. Maintaining a normal body weight and placing a lower level of importance on facial appearance had significant positive associations. Gender had no significant associations. Conclusion: In this study, the attribution aspect of body esteem had a greater negative impact on patients than their appearance and body weight. This has important implications for clinical treatment and support of patients.
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Virji, M. Abbas, Christine R. Schuler, Jean Cox-Ganser, Marcia L. Stanton, Michael S. Kent, Kathleen Kreiss e Aleksandr B. Stefaniak. "Associations of Metrics of Peak Inhalation Exposure and Skin Exposure Indices With Beryllium Sensitization at a Beryllium Manufacturing Facility". Annals of Work Exposures and Health 63, n. 8 (4 settembre 2019): 856–69. http://dx.doi.org/10.1093/annweh/wxz064.
Testo completoAbstract (sommario):
Abstract Objectives Peak beryllium inhalation exposures and exposure to the skin may be relevant for developing beryllium sensitization (BeS). The objective of this study was to identify risk factors associated with BeS to inform the prevention of sensitization, and the development of chronic beryllium disease (CBD). Methods In a survey of short-term workers employed at a primary beryllium manufacturing facility between the years 1994–1999, 264 participants completed a questionnaire and were tested for BeS. A range of qualitative and quantitative peak inhalation metrics and skin exposure indices were created using: personal full-shift beryllium exposure measurements, 15 min to 24 h process-specific task and area exposure measurements, glove measurements as indicator of skin exposure, process-upset information gleaned from historical reports, and self-reported information on exposure events. Hierarchical clustering was conducted to systematically group participants based on similarity of patterns of 16 exposure variables. The associations of the exposure metrics with BeS and self-reported skin symptoms (in work areas processing beryllium salts as well as in other work areas) were evaluated using correlation analysis, log-binomial and logistic regression models with splines. Results Metrics of peak inhalation exposure, indices of skin exposure, and using material containing beryllium salts were significantly associated with skin symptoms and BeS; skin symptoms were a strong predictor of BeS. However, in this cohort, we could not tease apart the independent effects of skin exposure from inhalation exposure, as these exposures occurred simultaneously and were highly correlated. Hierarchical clustering identified groups of participants with unique patterns of exposure characteristics resulting in different prevalence of BeS and skin symptoms. A cluster with high skin exposure index and use of material containing beryllium salts had the highest prevalence of BeS and self-reported skin symptoms, followed by a cluster with high inhalation and skin exposure index and a very small fraction of jobs in which beryllium salts were used. A cluster with low inhalation and skin exposure and no workers using beryllium salts had no cases of BeS. Conclusion Multiple pathways and types of exposure were associated with BeS and may be important for informing BeS prevention. Prevention efforts should focus on controlling airborne beryllium exposures with attention to peaks, use of process characteristics (e.g. the likelihood of upset conditions to design interventions) minimize skin exposure to beryllium particles, and in particular, eliminate skin contact with beryllium salts to interrupt potential exposure pathways for BeS risk.
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BENKABOU, F. "TEMPERATURE EFFECT ON THERMOMECHANICAL PROPERTIES OF BERYLLIUM CHALCOGENIDES BeS, BeSe AND BeTe". Modern Physics Letters B 20, n. 01 (10 gennaio 2006): 49–61. http://dx.doi.org/10.1142/s0217984906009177.
Testo completoAbstract (sommario):
We have used the molecular-dynamic method for the calculation of the structural, dynamic and elastic properties of group BeS , BeSe and BeTe compounds for temperature ranging from 300 to 1200 K. Tersoff potential has been used to model the interaction between the groups II–VI compound atoms. The structural properties of cubic BeS , BeSe and BeTe have been calculated, and good agreement between the calculated and experimental values have been found. We have also predicted the elastic constants and diffusion coefficients of BeS , BeSe and BeTe . The values found compare very well with the theoretical results. For the temperature range under study, all elastic constants and dynamic properties show a softening with increasing temperature very similar to the theoretical calculations.
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Miniutti, Ann M. "Language Deficiencies in Inner-City Children With Learning and Behavioral Problems". Language, Speech, and Hearing Services in Schools 22, n. 2 (aprile 1991): 31–38. http://dx.doi.org/10.1044/0161-1461.2202.31.
Testo completoAbstract (sommario):
The language skills of 27 learning disabled (LD), 27 behaviorally disordered (BD), and 26 normal achieving (NA) 6- to 9-year-old children were compared on the Clinical Evaluation of Language Fundamentals-Revised (CELF-R). A series of ANOVA procedures for the CELF-R standard scores revealed significant differences between the NA group and both special education groups on all subtests, clusters, and the total language score, but no significant differences were found between the LD and BD groups. The behavioral deviancy of a language-deficient special education subgroup, a language-competent special education subgroup, and the NA group was compared on the Behavioral Evaluation Scale (BES). Analysis of variance for the BES total standard scores showed significantly higher behavioral deviancy for the language-deficient subgroup than the NA group, but no significant difference between the language-competent subgroup and the NA group.
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Davidson, Gabrielle L., Nicola S. Clayton e Alex Thornton. "Salient eyes deter conspecific nest intruders in wild jackdaws ( Corvus monedula )". Biology Letters 10, n. 2 (febbraio 2014): 20131077. http://dx.doi.org/10.1098/rsbl.2013.1077.
Testo completoAbstract (sommario):
Animals often respond fearfully when encountering eyes or eye-like shapes. Although gaze aversion has been documented in mammals when avoiding group-member conflict, the importance of eye coloration during interactions between conspecifics has yet to be examined in non-primate species. Jackdaws ( Corvus monedula ) have near-white irides, which are conspicuous against their dark feathers and visible when seen from outside the cavities where they nest. Because jackdaws compete for nest sites, their conspicuous eyes may act as a warning signal to indicate that a nest is occupied and deter intrusions by conspecifics. We tested whether jackdaws’ pale irides serve as a deterrent to prospecting conspecifics by comparing prospectors’ behaviour towards nest-boxes displaying images with bright eyes (BEs) only, a jackdaw face with natural BEs, or a jackdaw face with dark eyes. The jackdaw face with BEs was most effective in deterring birds from making contact with nest-boxes, whereas both BE conditions reduced the amount of time jackdaws spent in proximity to the image. We suggest BEs in jackdaws may function to prevent conspecific competitors from approaching occupied nest sites.
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Ki, You-Jeong, Kyung Woo Park, Jeehoon Kang, Chee-Hoon Kim, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon-Kwon Koo e Hyo-Soo Kim. "Safety and Efficacy of Second-Generation Drug-Eluting Stents in Real-World Practice: Insights from the Multicenter Grand-DES Registry". Journal of Interventional Cardiology 2020 (26 febbraio 2020): 1–9. http://dx.doi.org/10.1155/2020/3872704.
Testo completoAbstract (sommario):
Objective. In this study, we sought to compare the efficacy and safety of the Xience Prime/Xience V/Promus EES and Biomatrix/Biomatrix Flex/Nobori BES with resolute integrity/resolute ZES using the grand drug-eluting stent (Grand-DES) registry. Background. Currently, new-generation drug-eluting stents (DESs) are used as the standard of care in patients undergoing percutaneous coronary intervention. No study has simultaneously compared everolimus-eluting stent (EES), biolimus-eluting stent (BES), and zotarolimus-eluting stent (ZES). Methods. Stent-related composite outcomes (target lesion failure) and patient-related composite outcomes were compared in crude and propensity score-matched analysis. Results. Of the 17,286 patients in the Grand-DES group, 5,137, 2,970, and 4,990 patients in the EES, BES, and ZES groups completed a three-year follow-up. In the propensity score-matched cohort, the stent-related outcome (EES vs. BES vs. ZES; 5.9% vs. 6.7% vs. 7.1%, P=0.226) and patient-related outcomes (12.7% vs. 13.5% vs. 14.3%, P=0.232) were similar among the three groups, at 3 years. The rate of definite or probable stent thrombosis (0.6% vs. 0.8% vs. 0.5%, P=0.549) was similar. In the multivariate analysis, chronic kidney disease was the strongest predictor of stent thrombosis (adjusted hazard ratio 3.178; 95% confidence interval 1.621–6.229; P<0.001). Conclusions. In this robust real-world registry with unrestricted use of EES, BES, and ZES, the three stent groups showed comparable safety and efficacy at the 3-year follow-up.
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Silva, Joao Carlos Marques, e José Pereira. "Novo Banco – what good out of a bad bank?" CASE Journal 16, n. 5 (12 agosto 2020): 551–84. http://dx.doi.org/10.1108/tcj-03-2019-0016.
Testo completoAbstract (sommario):
Research methodology Analysis of public sources. Case overview/synopsis The bank named “Novo Banco” (New Bank in Portuguese) was created because of an emergency intervention by the Bank of Portugal to save the “good” assets of the once great but bankrupt Banco Espírito Santo (BES) on August 4, 2014. The toxic assets remained in BES (dubbed “bad bank”). BES was one of the biggest private banks in Portugal, with origins mounting back to the year 1869. In 2013, it was headed by the founder’s great-grandson, Ricardo Salgado, when an external audit revealed several problems with the bank’s accounting and concluded that BES had a severe financial problem (the risky credit represented 11.1% of the bank’s accounts). The bank underwent a public capital increase (endorsed by several public figures, including the Portuguese President at the time, Cavaco Silva) of €1.045m to reposition itself, which was 100% successful (demand of about 160%, with a significant part of foreign investors). However, continued amounts of suspicions led Ricardo Salgado to be replaced by Vitor Bento (via a settlement between BES’s shareholders and the Bank of Portugal) in July 2014. At the end of that same month, BES announced imparities totaling the amount of €4.2535m. This led the European Central Bank to suspend BES’s access to the financial operations, forcing it to reimburse its credit to the Eurosystem in the value of €10.000m. In two days, the stock prices dropped by 80% to around €0.03 per share. It was later proven that the administration led by Ricardo Salgado had disobeyed the Bank of Portugal 21 times between December 2013 and July 2014, apparently acting against the institution’s best interests. Some carousel schemes with companies within the Espirito Santo Group were also detected in BES’ financial movements to improve the bank’s financial statements. Complexity academic level Finance Valuation, Strategy
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Choe, Jeong Cheon, Kwang Soo Cha, Hye Yoon Jang, Jong Hyun Choi, Bo Won Kim, Jinhee Ahn, Jin Sup Park et al. "Outcomes of Acute Myocardial Infarction Patients Implanted With Biodegradable Polymer Biolimus-Eluting Stents Versus New-Generation Durable Polymer Drug-Eluting Stents: A Retrospective Analysis". Angiology 68, n. 8 (20 novembre 2016): 698–706. http://dx.doi.org/10.1177/0003319716679339.
Testo completoAbstract (sommario):
We compared outcomes between biodegradable polymer biolimus-eluting stent (BP-BES) and new-generation durable polymer drug-eluting stent (DP-DES) implantations in patients with acute myocardial infarction (MI). Among 13472 patients with acute MI in a nationwide registry, 557 (64.8%) were in the BP-BES and 303 (35.2%) in the new-generation DP-DES group following coronary reperfusion. The occurrence of major adverse cardiac events (MACE; death, MI, revascularization) and stent thrombosis was compared. Major adverse cardiac events occurred in 53 (6.2%) patients and showed similar rates between the BP-BES and new-generation DP-DES groups (all: 6.6% vs 5.9%, P = .652; propensity score [PS] matched: n = 380, 6.3% vs 5.3%, P = .623). Stent thrombosis did not differ between groups (all: 0.3% vs 0.4%, P = .892; PS matched: 0.5% vs 0.5%, P = 1.000). Major adverse cardiac event-free survival was comparable between groups (all: 93.4% vs 94.1%, log-rank P = .357; PS matched: 93.7% vs 94.7%, log-rank P = .445). Biodegradable polymer biolimus-eluting stent was not associated with MACE (all: hazard ratio [HR], 1.67; 95% confidence interval [CI], 0.75-3.74; P = 0.212; PS matched: HR, 1.05; 95% CI, 0.40-2.75; P = .915). In conclusion, in patients with acute MI, BP-BES was equivalent to the new-generation DP-DES in terms of outcomes.
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Stefano, S. C., A. M. R. Devoraes, A. M. R. Souza, M. H. Kaio e S. L. Blay. "Psychoeducational manual for treating binge eating disorder (BED) patients: A controlled trial". European Psychiatry 26, S2 (marzo 2011): 730. http://dx.doi.org/10.1016/s0924-9338(11)72435-x.
Testo completoAbstract (sommario):
ObjectiveTo evaluate the efficacy of a psychoeducational manual as first intervention when treating BED.MethodIt was conducted a 8-week controlled trial (before-after) without a control group. Twenty BED patients were enrolled at an outpatient service specialized in eating disorders (PROATA).After being submitted to a psychiatric evaluation and responding to the following instruments: MINI-PLUS, QEWP-R, BES, BDI, HAM-A, SF-36, and BSQ, the subjects signed a consent term and they received explanations about the manual. After eight weeks the patients were re-evaluated by trained examiners.The main outcome criterion was the BED evolution (evaluated through QEWP-R and BES). The secondary criteria were evaluated through the other instruments plus a semi-structured interview.ResultsMost patients presented a slight improvement of BED symptoms, although these symptoms are still present. The secondary criteria show that the most relevant aspect was that the information presented in the manual allowed the patients to acknowledge they had a condition and to see themselves with less guilt and prejudice, making it easier to look for a more comprehensive treatment.ConclusionsThere are indications that using the psychoeducational manual can reduce the symptoms, and that it can be useful in identifying the condition and allowing the patients to look for treatment. Also, since the instrument can be used as part of a stepped-care program, a broader, controlled and randomized study enrolling a larger number of patients must be conducted in order to better clarify the results.
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Escuriola Ettingshausen, Carmen, e Robert F. Sidonio. "Design of an international investigator-initiated study on MOdern Treatment of Inhibitor-positiVe pATiEnts with haemophilia A (MOTIVATE)". Therapeutic Advances in Hematology 12 (gennaio 2021): 204062072110324. http://dx.doi.org/10.1177/20406207211032452.
Testo completoAbstract (sommario):
Background: Inhibitor development is the most serious treatment-related complication of replacement coagulation factor VIII (FVIII) therapy for patients with haemophilia A. Immune tolerance induction (ITI), which involves intensive and prolonged treatment with plasma-derived or recombinant FVIII, is the only clinically proven strategy for eradication of inhibitors. The bispecific antibody emicizumab is approved for use in patients with and without inhibitors to prevent bleeding but does not eliminate inhibitors. MOTIVATE ( www.motivate-study.com ) aims to capture different approaches to the treatment and management of patients with haemophilia A and inhibitors, document current ITI approaches from real-world clinical experience, and evaluate the efficacy and safety of ITI, emicizumab prophylaxis and ITI with emicizumab prophylaxis. Methods: The investigator-initiated MOTIVATE study [ClinicalTrials.gov identifier: NCT04023019; EudraCT 2019-003427-38] will investigate in real-life clinical practice the management of patients with haemophilia A of any severity who have developed inhibitors to FVIII. All treatment is at the investigator’s discretion. The following treatment approaches will be evaluated: Group 1 – ITI with Nuwiq®, octanate® or wilate® and aPCC/rFVIIa if needed to treat bleeding episodes (BEs) or during surgery or for prophylaxis; Group 2 – ITI with Nuwiq®, octanate® or wilate® and emicizumab prophylaxis and aPCC/rFVIIa if needed to treat BEs or during surgery; Group 3 – routine prophylaxis with emicizumab, aPCC or rFVIIa without ITI and aPCC/rFVIIa if needed to treat BEs or during surgery. Patients will not be randomised to a treatment group and may change groups during the study. Conclusions: It is planned to enrol 120 patients who will be followed for up to 5 years. Optional sub-studies will explore factors that may influence ITI results as well as the impact of different treatment approaches on important aspects of patient health, including joint and bone health and the risk of thrombotic events.
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Bonnet, R., J. L. M. Sampaio, C. Chanal, D. Sirot, C. De Champs, J. L. Viallard, R. Labia e J. Sirot. "A Novel Class A Extended-Spectrum β-Lactamase (BES-1) in Serratia marcescens Isolated in Brazil". Antimicrobial Agents and Chemotherapy 44, n. 11 (1 novembre 2000): 3061–68. http://dx.doi.org/10.1128/aac.44.11.3061-3068.2000.
Testo completoAbstract (sommario):
ABSTRACT Serratia marcescens Rio-5, one of 18 extended-spectrum β-lactamase (ESBL)-producing strains isolated in several hospitals in Rio de Janeiro (Brazil) in 1996 and 1997, exhibited a high level of resistance to aztreonam (MIC, 512 μg/ml) and a distinctly higher level of resistance to cefotaxime (MIC, 64 μg/ml) than to ceftazidime (MIC, 8 μg/ml). The strain produced a plasmid-encoded ESBL with a pI of 7.5 whose bla gene was not related to those of other plasmid-mediated Ambler class A ESBLs. Cloning and sequencing revealed a bla gene encoding a novel class A β-lactamase in functional group 2be, designated BES-1 (Brazil extended-spectrum β-lactamase). This enzyme had 51% identity with chromosomal class A penicillinase of Yersinia enterocolitica Y56, which was the most closely related enzyme and 47 to 48% identity with CTX-M-type β-lactamases, which were the most closely related ESBLs. In common with CTX-M enzymes, BES-1 exhibited high cefotaxime-hydrolyzing activity (k cat, 425 s−1). However, BES-1 differed from CTX-M enzymes by its significant ceftazidime-hydrolyzing activity (k cat, 25 s−1), high affinity for aztreonam (Ki , 1 μM), and lower susceptibility to tazobactam (50% inhibitory concentration [IC50], 0.820 μM) than to clavulanate (IC50, 0.045 μM). Likewise, certain characteristic structural features of CTX-M enzymes, such as Phe-160, Ser-237, and Arg-276, were observed for BES-1, which, in addition, harbored different residues (Ala-104, Ser-171, Arg-220, Gly-240) and six additional residues at the end of the sequence. BES-1, therefore, may be an interesting model for further investigations of the structure-function relationships of class A ESBLs.
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Asmari Bardezard, Yousef, Sajad Khanjani, Esmaeil Mousavi Asl e Behrouz Dolatshahi. "Effect of Emotion-focused Therapy on Anxiety, Depression and Difficulty in Emotion Regulation in Women With Binge Eating Disorder". Iranian Journal of Psychiatry and Clinical Psychology 27, n. 1 (1 aprile 2021): 2–15. http://dx.doi.org/10.32598/ijpcp.27.1.3246.1.
Testo completoAbstract (sommario):
Objectives: This study aims to investigate the effect of Emotion-Focused Therapy (EFT) on depression, anxiety, and Difficulty in Emotion Regulation (DER) in women with Binge Eating Disorder (BED). Methods: This is a quasi-experimental study with pre-test/post-test/follow-up design using a control group. Study population consists of all women referred to the obesity clinics in Tehran in 2019. Of these, 40 were selected using a purposive sampling method and were randomly divided into two groups of intervention (n=20) and control (n=20). The intervention group received 10 sessions of EFT, each session for 90 minutes. Data collection tools were the Beck Anxiety Inventory (BAI), the Beck Depression Inventory II (BDI-II), Difficulties in Emotion Regulation Scale (DERS), and Binge Eating Scale (BES), which were completed before and after the intervention. Data were analyzed using descriptive statistics and repeated measure ANIVA in SPSS v. 21 software. Results: Group EFT significantly reduced the mean anxiety, depression, DER and severity of binge eating after intervention and over the 2-month follow-up period in BED women (P<0.05). Conclusion: The EFT can reduce anxiety, depression, DER and binge eating severity in BED women, and its effect remains constant after two months. It can be useful in the treatment of BED.
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Boccia, L., A. De Rosa, L. Attanasio, R. Di Palo, L. Zicarelli e B. Gasparrini. "239 CAPACITATION OF BUFFALO SPERMATOZOA IN VITRO". Reproduction, Fertility and Development 17, n. 2 (2005): 270. http://dx.doi.org/10.1071/rdv17n2ab239.
Testo completoAbstract (sommario):
The efficiency of in vitro embryo production (IVEP) in buffalo is hampered by the poor cleavage rate. The quality of the frozen semen may affect fertilization efficiency, due to damages of the male gamete that occur following cryopreservation. However, it is not possible to rule out that the process of capacitation, required by spermatozoa to acquire the fertilizing ability, is impaired in the IVF system. Although several agents have been proven to induce sperm capacitation in vitro, heparin is still the most efficient method in most of the domestic species. The aim of the study was to evaluate the efficiency of buffalo estrus serum (BES) and follicular fluid (FF) to induce buffalo sperm capacitation in vitro, indirectly assessed by estimating the capability of spermatozoa to acrosome react. Frozen semen from a bull previously tested for IVF, thawed at 37°C for 40 s in water, was treated by swim-up in order to select only the motile population. Spermatozoa (n = 1546) were assessed immediately after swim-up separation, to evaluate the incidence of acrosomal loss in nontreated cells (time 0). The remaining spermatozoa were incubated in the presence of 0.01 mM heparin (control; n = 3531), 20% BES (n = 2442) and 20% FF (n = 1419), the latter recovered from a pool of dominant follicles, for 1, 2, and 3 hours. Sperm was then exposed for 15 min to 60 μg mL−1 of lysophosphatidylcholine, an agent known to induce acrosome reaction only on capacitated spermatozoa. Trypan blue was used to differentiate live from dead spermatozoa, and the dried smears were then fixed in 37% formaldehyde and stained with Giemsa for acrosome evaluation by microscopic examination. The proportion of acrosome-reacted spermatozoa in each group was used to assess the efficiency of capacitation under different incubation conditions. Differences between groups were analyzed by χ2. No dead spermatozoa were found in all groups. Acrosomal loss was observed in only 15.3% of the sperm population at time 0; it may be accounted for either by damages preceding cell death or by freezing-induced capacitation. No differences were found between incubation times within each treatment group. Interestingly, sperm treatment with both BES and FF resulted in a significantly higher incidence of acrosome reaction compared with heparin (84.3, 94.5 vs. 50.1%, respectively; P < 0.001), the capacitating agent currently used in the IVF system, and, in particular, FF showed the highest percentage of acrosome reaction at all incubation times, even when compared with BES (P < 0.01). It is likely that factors derived by BES and FF, present in the oviduct environment around fertilization, play a critical role in processing the male gamete in vivo. These preliminary results show the possibility of significantly improving the efficiency of sperm capacitation in vitro in buffalo species with BES and FF and strongly suggest investigating the effects of these factors also on the fertilizing capability of buffalo spermatozoa. The authors thank to Dr. O. Paciello for his technical assistance.
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Liesner, Raina, Martina Jansen, Anna Klukowska, Vladimir Vdovin, Tomasz Szczepanski e Sigurd Knaub. "Efficacy, Immunogenicity, Pharmacokinetics, and Safety Of Human-cl rhFVIII – a GCP Study In Children With Severe Haemophilia A". Blood 122, n. 21 (15 novembre 2013): 3594. http://dx.doi.org/10.1182/blood.v122.21.3594.3594.
Testo completoAbstract (sommario):
Abstract Introduction Human-cl rhFVIIIis the first recombinant factor VIII concentrate expressed in a human cell line (Human Embryonic Kidney 293F cells). Studies in adolescent and adult pre-treated patients with severe haemophilia A showed a favorable PK profile with a median half-life of 17.1 hours (one stage assay) and indicated safety and efficacy in preventing and treating bleeding episodes (BE). Aims The objectives of this international GCP study were to evaluate the efficacy, safety, immunogenicity and pharmacokinetic (PK) properties of Human-cl rhFVIIIin previously treated children between 2 and 12 years of age. Methods All patients started with an in-vivo recovery (IVR) investigation and in a subset of patients, the PK of Human-cl rhFVIII was assessed in comparison to the patient’s previously used FVIII product. After an injection of 50 IU/kg, blood samples were collected up to 48 hours for PK analysis and up to 2 hours for IVR. IVR was repeated in all patients after 3 and 6 months. FVIII plasma levels were measured by chromogenic and one-stage assay in a central laboratory. Patients were treated prophylactically with Human-cl rhFVIII every other day or 3x weekly, injecting 30-40 IU Human-cl rhFVIIIper kg for at least 6 months and > 50 exposure days. Inhibitors were measured before, during and at the end of the study by modified Nijmegen Bethesda assay in a central laboratory. Adverse events were recorded throughout the study. Results 59 patients (29: 2-5 years; 30: 6-12 years) were enrolled from 15 specialized sites in Europe. 13 children of each age group participated in the comparative PK investigation. Mean PK parameters of Human-cl rhFVIII were similar in both age groups for both the chromogenic and the one-stage assay: AUCnorm 0.23 vs. 0.24 h*IU/mL/[IU/kg]); IVR 1.88 vs. 1.61% per IU/kg; T1/2 9.7 vs. 12.5 h. IVR remained stable throughout the study. A total of 108 BEs in 32/59 patients were treated with Human-cl rhFVIII. The majority of treated BEs were traumatic (60.2%) and minor (56.5%). The mean ± SD monthly bleeding rate of all types of BEs/patient was 0.34±0.43 (spontaneous BEs: 0.12±0.27; traumatic BEs: 0.19±0.29). No inhibitor development was reported; no patient discontinued the study because of an AE. Conclusion The data indicate that Human-cl rhFVIII is efficacious and safe in preventing and treating BEs in previously treated children. The PK of Human-cl rhFVIII was comparable in both studied age groups. Disclosures: Liesner: Octapharma AG: Consultancy, Investigator Other. Jansen:Octapharma AG: Employment. Klukowska:Octapharma AG: Investigator Other. Vdovin:Octapharma AG: Investigator Other. Szczepanski:Octapharma AG: Investigator Other. Knaub:Octapharma AG: Employment.
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Melo, Paulla Guimarães, Maria do Rosário Gondim Peixoto e Erika Aparecida da Silveira. "Binge eating prevalence according to obesity degrees and associated factors in women". Jornal Brasileiro de Psiquiatria 64, n. 2 (giugno 2015): 100–106. http://dx.doi.org/10.1590/0047-2085000000064.
Testo completoAbstract (sommario):
Objective Investigate binge eating (BE) prevalence in women according to the obesity degree and assess the associated factors. Methods Cross-sectional study with female adults presenting body mass index (BMI) ≥ 35 kg/m2. The analyzed variables were: sociodemographics, health status, obesity history, lifestyle, eating behavior and obesity degree. In order to analyse BE it was used the Binge Eating Scale (BES), which is considered positive when BES ≥ 18 points. Prevalence and prevalence ratios (PR) were calculated with confidence intervals (CI) of 95%. Multivariate analysis was carried out using Poisson regression. Results BE prevalence was 53.2%, and the prevalence in super superobese women (BMI ≥ 60 kg/m2) was 75%. After multivariate analysis, associations were observed between the age group 40-49 years old (PR = 2.0; 95% CI = 1.2-3.4) and the “snacking habit” (PR = 1.9; 95% CI = 1.2-2.9). Conclusion The prevalence of BE in severe obese women was high. Association with the “snacking habit” can be a BE marker that should be monitored in the severely obese individuals that fit this profile.
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Kim, HyeJin, Isabel M. D. Rosa, Rob Alkemade, Paul Leadley, George Hurtt, Alexander Popp, Detlef P. van Vuuren et al. "A protocol for an intercomparison of biodiversity and ecosystem services models using harmonized land-use and climate scenarios". Geoscientific Model Development 11, n. 11 (13 novembre 2018): 4537–62. http://dx.doi.org/10.5194/gmd-11-4537-2018.
Testo completoAbstract (sommario):
Abstract. To support the assessments of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services (IPBES), the IPBES Expert Group on Scenarios and Models is carrying out an intercomparison of biodiversity and ecosystem services models using harmonized scenarios (BES-SIM). The goals of BES-SIM are (1) to project the global impacts of land-use and climate change on biodiversity and ecosystem services (i.e., nature's contributions to people) over the coming decades, compared to the 20th century, using a set of common metrics at multiple scales, and (2) to identify model uncertainties and research gaps through the comparisons of projected biodiversity and ecosystem services across models. BES-SIM uses three scenarios combining specific Shared Socio-economic Pathways (SSPs) and Representative Concentration Pathways (RCPs) – SSP1xRCP2.6, SSP3xRCP6.0, SSP5xRCP8.6 – to explore a wide range of land-use change and climate change futures. This paper describes the rationale for scenario selection, the process of harmonizing input data for land use, based on the second phase of the Land Use Harmonization Project (LUH2), and climate, the biodiversity and ecosystem services models used, the core simulations carried out, the harmonization of the model output metrics, and the treatment of uncertainty. The results of this collaborative modeling project will support the ongoing global assessment of IPBES, strengthen ties between IPBES and the Intergovernmental Panel on Climate Change (IPCC) scenarios and modeling processes, advise the Convention on Biological Diversity (CBD) on its development of a post-2020 strategic plans and conservation goals, and inform the development of a new generation of nature-centred scenarios.
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Li, Li, Lori J. Silveira, Nabeel Hamzeh, May Gillespie, Peggy M. Mroz, Annyce S. Mayer, Tasha E. Fingerlin e Lisa A. Maier. "Beryllium-induced lung disease exhibits expression profiles similar to sarcoidosis". European Respiratory Journal 47, n. 6 (21 aprile 2016): 1797–808. http://dx.doi.org/10.1183/13993003.01469-2015.
Testo completoAbstract (sommario):
A subset of beryllium-exposed workers develop beryllium sensitisation (BeS) which precedes chronic beryllium disease (CBD). We conducted an in-depth analysis of differentially expressed candidate genes in CBD.We performed Affymetrix GeneChip 1.0 ST array analysis on peripheral blood mononuclear cells (PBMCs) from 10 CBD, 10 BeS and 10 beryllium-exposed, nondiseased controls stimulated with BeSO4or medium. The differentially expressed genes were validated by high-throughput real-time PCR in this group and in an additional group of cases and nonexposed controls. The functional roles of the top candidate genes in CBD were assessed using a pharmacological inhibitor. CBD gene expression data were compared with whole blood and lung tissue in sarcoidosis from the Gene Expression Omnibus.We confirmed almost 450 genes that were significantly differentially expressed between CBD and controls. The top enrichment of genes was for JAK (Janus kinase)–STAT (signal transducer and activator of transcription) signalling. A JAK2 inhibitor significantly decreased tumour necrosis factor-α and interferon-γ production. Furthermore, we found 287 differentially expressed genes overlapped in CBD/sarcoidosis. The top shared pathways included cytokine–cytokine receptor interactions, and Toll-like receptor, chemokine and JAK–STAT signalling pathways.We show that PBMCs demonstrate differentially expressed gene profiles relevant to the immunnopathogenesis of CBD. CBD and sarcoidosis share similar differential expression of pathogenic genes and pathways.
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Ravin, Victor, Liisa Räisänen e Tapani Alatossava. "A Conserved C-Terminal Region in Gp71 of the Small Isometric-Head Phage LL-H and ORF474 of the Prolate-Head Phage JCL1032 Is Implicated in Specificity of Adsorption of Phage to Its Host, Lactobacillus delbrueckii". Journal of Bacteriology 184, n. 9 (1 maggio 2002): 2455–59. http://dx.doi.org/10.1128/jb.184.9.2455-2459.2002.
Testo completoAbstract (sommario):
ABSTRACT Thirty-five phage-resistant mutants of Lactobacillus delbrueckii subsp. lactis ATCC 15808 were selected. Thirty-three of these mutants were assigned to the Bes group, while the remaining two were grouped under the Ads designation. Bes group mutants adsorbed phage LL-H but did not allow efficient phage development. Preliminary evidence suggests that these strains exhibit a mutation that changes the DNA specificity of a restriction-modification system. The Ads group mutants did not adsorb the small isometric-head phage LL-H. The results suggest that there are at least three different types of phage receptors in L. delbrueckii: two that are specific for small isometric-head phages and one that is specific for prolate-head phage JCL1032. Five LL-H host-range mutants which could overcome the adsorption block (a-type mutants) were selected and investigated by sequencing the genes g71 and g17, which encode minor and major tail proteins, respectively. Each of the a-type mutants carried a nucleotide change at the 3′ end of gene g71. No mutations were observed in gene g17. Comparison of the gene product of g71 of phage LL-H with its homolog in JCL1032 (ORF474) showed that these proteins had very similar C-terminal regions. No similarities were found at the N-terminal part of the proteins. We conclude that the C-terminal portion of the protein encoded by g71 of phage LL-H and its homolog in phage JCL1032 determines the adsorption specificities of these phages on L. delbrueckii.
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Barak, Yoram, Yair Lampl, Ida Sarova-Pinchas e Anat Achiron. "Self and Body Esteem Perception in Multiple Sclerosis". Behavioural Neurology 11, n. 3 (1999): 159–61. http://dx.doi.org/10.1155/1999/976453.
Testo completoAbstract (sommario):
Self esteem and body esteem were examined in a group of 35 relapsing-remitting multiple sclerosis (MS) patients using the Body Esteem Scale (BES) and the Eysenck Self Esteem Scale (ESES) and compared to age and sex matched normal controls.There were 23 females and 12 males in the MS patient’s group; average age 38.9 years (range: 22–52). All participants completed the self-rated BES evaluating the following subscales: females—sexual attractiveness, physical condition and weight concern; males—physical attractiveness, physical condition and upper body strength. In addition all participants were scored, following a semi-structured interview, on the ESES. Psychiatric co-morbidity was excluded using a semi-structured interview by the consulting psychiatrist. All evaluations were carried out during the remitting phase. Statistical analysis, comparing patients to healthy controls, demonstrated lowered self-rating of the physical condition (males < 0.05, females < 0.001). On the other hand, no significant differences were found in the physical (male) or sexual (female)—attractiveness subscales. The mean ESES score in the patients group was 23.2 ± 4.0, slightly above the reported average. The controls mean ESES was 28.4 ± 3.6, (P< 0.05). No correlation was found between self and body esteem amongst M.S. patients. This study emphasizes impaired perception of body esteem in multiple sclerosis patients even in remission. The preservation of physical and sexual attractiveness may be related to the non-disfiguring nature of the disease. Preservation of self-esteem in MS patients suggests that body-esteem should be the focus of supportive treatment.
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Kurbanova, Z. I. "Karakalpak Family Ritualism: The Bes Kiyim Custom in the Transformation of Traditional Culture". Archaeology, Ethnology & Anthropology of Eurasia 48, n. 3 (4 ottobre 2020): 124–33. http://dx.doi.org/10.17746/1563-0110.2020.48.3.124-133.
Testo completoAbstract (sommario):
This study describes the bridal and funerary rite of exchanging clothes (Bes Kiyim – ‘Five Costumes’) in the context of the traditions and innovations in the Karakalpak culture. On the basis of fi eld data collected in 2014–2019 and earlier in places with a continuous or patchy distribution of the Karakalpak population (Chimbaysky, Karauzyaksky, Kegeyliysky, Nukussky, Khodzheyliysky, and the Takhiatashsky districts of the Republic of Karakalpakstan, Republic of Uzbekistan) and of earlier sources, changes in ritualism are analyzed. Bridal rites include exchanges of gifts, such as items of clothing. The comparison of sources shows that the Bes Kiyim rite originated in the mid-20th century in the context of socio-cultural changes. It has remained rather stable up to the present time, being an integral part of Karakalpak bridal ritualism. This indicates its importance in the normative culture of that ethnic group. In one district of Karakalpakstan, the term Bes Kiyim was transferred from the bridal to the funerary rituals. The origin of the rite relates to the transformation of the Iyis custom—the distribution of the deceased person’s clothing among those participating in the ablution of the body. In the late 20th century, specially purchased items of clothing began to be used for that purpose. Apparently, the fi ve items distributed among those participating in the rite symbolize the deceased person’s transition to the ancestors’ world. By the same token, the bride’s fi ve outfi ts allude to her passage to the category of married women and the beginning of her marital life. Therefore, the ritual innovations of the Karakalpaks, caused by socio-cultural and economic changes, mirror the logic and content of traditional family festivals whose complex symbolism relates to status change.
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Brandao, Leonardo R., Igor Tartakovsky, Manuela Albisetti, Lisa Bomgaars, Elizabeth Chalmers, Lesley Mitchell, Matteo Luciani et al. "Efficacy and Safety of Dabigatran in the Treatment and Secondary Prophylaxis of Children with Venous Thromboembolism and Thrombophilia". Blood 136, Supplement 1 (5 novembre 2020): 35–36. http://dx.doi.org/10.1182/blood-2020-136695.
Testo completoAbstract (sommario):
Background: Thrombophilia in children is characterized by hypercoagulability and increased frequency of thrombotic events (Young G, et al. Circulation. 2008;118:1373-1378; Kenet G, et al. Circulation. 2010;121:1838-1847). Recently, phase IIb/III clinical trials in children with venous thromboembolism (VTE) have reported the non-inferiority of dabigatran etexilate (DE) versus standard of care (SOC) for the treatment of acute VTE (Albisetti M, et al. ISTH 2019, Abstract OC 57.3), and a favorable safety profile for DE in secondary VTE prevention in children with persistent VTE risk factor(s) (Brandão LR, et al. Blood. 2020;135:491-504). Aims: To perform a subgroup analysis evaluating the efficacy and safety of DE for the treatment and secondary prophylaxis of VTE in children with thrombophilia in the phase IIb/III DE clinical trials. Methods: In the open-label, phase IIb/III DIVERSITY trial (NCT01895777), children aged from birth to < 18 years (yrs) with an objectively confirmed VTE diagnosis (by imaging studies) initially treated with unfractionated heparin or low-molecular-weight heparin were randomized (2:1) to receive up to 3 months of DE or SOC. Primary composite efficacy endpoint: complete thrombus resolution and freedom from VTE recurrence, or VTE-related death. Safety endpoints included bleeding events (BEs). The open-label, phase III, secondary VTE prevention trial (NCT02197416) treated children aged from > 3 months to < 18 yrs with DE for up to 12 months or less, if the identified VTE clinical risk factor resolved. Eligible children had an objectively confirmed diagnosis of VTE treated with SOC for ≥ 3 months, or had completed DE or SOC treatment in DIVERSITY and had an unresolved clinical VTE risk factor requiring further anticoagulation. Primary endpoints included VTE recurrence and BEs. Thrombophilia status was confirmed according to the definitions used by the local experts. Results: In DIVERSITY, 23.2% of children had thrombophilia; demographics were comparable to the overall population, although they were slightly older (mean [standard deviation] age 13.2 [4.9] vs 11.1 [6.1] years in the overall population; p = 0.005). In children with thrombophilia, DE was found to be non-inferior to SOC for the primary endpoint (similar to the overall population), and more children treated with DE achieved the composite primary endpoint than with SOC (SOC 21.7% vs DE 35.9%; Mantel-Hänszel-weighted difference in rates for SOC minus DE [90% CI] −0.14 [−0.32 to 0.05]; p for non-inferiority = 0.0014), similar to the overall population (Table). Regardless of treatment, VTE recurrence appeared higher in children with thrombophilia than in the overall population, with numerically fewer VTE recurrences reported by children with thrombophilia treated with DE (7.7%) versus SOC (21.7%), although this was not significantly lower (p = 0.13). Numerical differences in residual thrombotic burden between SOC vs DE seen in the overall population appeared to be amplified in children with thrombophilia. Numerically fewer children with thrombophilia treated with DE reported thrombus progression (SOC 13.0% vs DE 5.1%) or stabilization (21.7% vs 10.3%), while more reported partial (34.8% vs 43.6%) or complete thrombus resolution (21.7% vs 35.9%). In the thrombophilia subgroup, BEs appeared to be lower in children treated with DE (SOC 26.1% vs DE 17.9%), while in the overall population BEs with SOC and DE were comparable. In the secondary VTE prevention trial, children with thrombophilia were also slightly older versus the overall population (mean [standard deviation] age 14.1 [3.6] vs 12.8 [4.6] yrs; p = 0.006). In this larger subgroup of children, rates of recurrent VTE at 12 months appeared to be higher in the thrombophilia group (2.8%) compared to the overall population (1.4%) (Table), with BEs largely comparable (27.4% and 22.5%, respectively). Conclusions: Unsurprisingly, numerically more children with thrombophilia appeared to report VTE recurrence, and in DIVERSITY thrombus progression/stabilization also seemed higher compared with the overall population. Compared with the overall populations, these subgroup analyses showed consistent results for DE in children with acute VTE and thrombophilia in the DIVERSITY trial, along with a favorable safety profile of DE for secondary VTE prevention. Disclosures Brandao: Boehringer Ingelheim: Other: Member of a paediatric expert working group. Tartakovsky:Boehringer Ingelheim: Current Employment. Albisetti:Boehringer Ingelheim: Other: Member of a paediatric expert working group; Daiichi Sankyo: Membership on an entity's Board of Directors or advisory committees. Bomgaars:Boehringer Ingelheim: Other: Member of a paediatric expert working group. Chalmers:CSL Behring: Honoraria; Shire/Takeda: Honoraria; Boehringer Ingelheim: Other: Member of a paediatric expert working group; Grifols: Honoraria; Roche: Honoraria; Sobi: Honoraria; Bristol-Myers Squibb: Honoraria. Mitchell:Boehringer Ingelheim: Other: Member of a paediatric expert working group. Luciani:Boehringer Ingelheim: Other: Member of a paediatric expert working group. Lvova:Boehringer Ingelheim: Honoraria. Simetzberger:Boehringer Ingelheim: Current Employment. Sun:Boehringer Ingelheim: Current Employment. Gergei:Boehringer Ingelheim: Current Employment. Brueckmann:Boehringer Ingelheim: Current Employment. Halton:Boehringer Ingelheim: Other: Member of a paediatric expert working group. OffLabel Disclosure: dabigatran etexilate in paediatric VTE
27
JIANG, Xiaowei, Jingyan Shi, Jiaheng Zou, Qingbao Hu, Ran Du e Zhenyu Sun. "Research and Exploit of Resource Sharing Strategy at IHEP". EPJ Web of Conferences 214 (2019): 03014. http://dx.doi.org/10.1051/epjconf/201921403014.
Testo completoAbstract (sommario):
At IHEP (Institute of High Energy Physics, Chinese Academy of Sciences), computing resources are contributed by different experiments including BES, JUNO, DYW, HXMT, etc. The resources were divided into different partitions to satisfy the dedicated experiment data processing requirements. IHEP had a local Torqu&Maui cluster with 50 queues serving for above 10 experiments. The separated resource partitions leaded to imbalance resource load. In a typical situation, BES resource partition was quite busy without free slot but still with lots of jobs in idle, while JUNO resources are free and wasted seriously. After moving resources from Torque&Maui to HTCondor in 2016, job scheduling efficiency has been improved a lot. In order to balance the imbalance resource load, we designed an efficient sharing strategy to improve the overall resourceutilization. We created an unified pool shared by all experiments. For each experiment, resources are divided into two parts: dedicated resource and sharing resource. The slots in dedicated resource only run jobs from its own experiment, and the slots in sharing resource are shared by jobs from all experiments. Default ratio of dedicated resource to sharing resource is 1:4. To maximize the sharing effectiveness, the ratio is dynamically adjusted between 0:5 and 4:1 based on the number of jobs submitted by each experiment. We have developed a central control system to decide how many resources can be allocated to each experiment group. This system is implemented at two sides: server side and client side. A management database is built at server side, which is storing resource, group and experiment information. Once the sharing ratio needs to be adjusted, resource group will be changed and updated into database. The resource group information is published to the server buffer in real-time. The client periodically pulls resource group information from server buffer via https protocol And resource scheduling configuration at client side is changed based on the resource group information. With this method, share ratio can be modified and deployed dynamically. Sharing strategy is implemented with HTCondor. ClassAd mechanism and accounting-group in HTCondor facilitate to utilizethe sharing strategy at IHEP computing cluster. With the sharing strategy, resource usage has been improved dramatically.
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Rahman, Shafia, Juan Trias, Mohammad Barouqa, Margarita Kushnir e Henny H. Billett. "Retrospective Comparison of Doac with Enoxaparin in Gastrointestinal and Urothelial Cancers". Blood 136, Supplement 1 (5 novembre 2020): 21. http://dx.doi.org/10.1182/blood-2020-143409.
Testo completoAbstract (sommario):
Introduction: Venous thromboembolic disease (VTE) is a common cause of morbidity and mortality in patients with cancer. Cancer associated thrombosis (CAT) is associated with poor prognosis, worse survival and increased care costs. Previous trials demonstrated the non-inferiority of DOACs to LMWH for the treatment of CAT, but there is concern for a possible increased incidence of bleeding, particularly in patients with gastrointestinal (GI) and urothelial (GU) cancers. Current guidelines suggest a preference for enoxaparin with these diagnoses. The aim of our study is to elucidate the safety of DOACs in the treatment of GI and GU cancer associated thrombosis at our institution. Methods: Retrospective chart review of patients with GI or GU cancer associated thrombosis who received either enoxaparin or DOACs (apixaban or rivaroxaban) was performed. The baseline characteristics, duration of anticoagulation (AC) and bleeding events (BEs) were compared between the two groups. The bleeding events were classified according to ISTH categories. Statistical analysis was done using R studio (V1.3.1056). Results: All patients from 01/2001 - 01/2020 with active GI or GU cancer and associated thrombosis who had received enoxaparin or a DOAC were included in the study. Of 262 patients reviewed, 206 (78.6 %) received a DOAC and 56 (21.4%) received enoxaparin. The baseline characteristics between the two groups are depicted in Table 1. Patients in the DOAC group had lower ECOG scores than those on enoxaparin: 79.7% of DOAC and 26.8% of enoxaparin patients had ECOG scores of 1-2. Patients on DOACs were less likely to have metastatic disease (58.7% vs. 78.6%) but were more likely to have additional risk factors for bleeding (p=0.004): 24 patients (11.7%) on DOACs were also on an antiplatelet agent (19 on aspirin, 5 on clopidogrel), compared to 4 patients (7.1%) in enoxaparin group (3 on aspirin, 1 on clopidogrel). Clot distribution was similar between the two groups. The majority of patients, 70.4% in the DOAC group and 73.2% in the enoxaparin group, had no BEs. There was no statistically significant difference in the cumulative incidence (CI) of bleeding between the DOAC and enoxaparin groups (p-value 0.65) Figure 1. In the DOAC group, 109 patients (52.9%) received apixaban and 97 patients (47.1%) received rivaroxaban. There were 26 (23.9%) and 35 (36.8%) BE in the apixaban and rivaroxaban subgroups respectively, Table 2. Of those on apixaban, 13/26 had GI bleeding (12 had underlying GI and 1 patient had GU cancer) and 10/26 had GU bleeding(all with underlying GU cancer). Of those on rivaroxaban 18/35 had GI bleeding (all with underlying GI cancer) and 11/35 had GU bleeding (6 patients had GU and 5 had GI cancer). Conclusion: Our study suggests that physician preferences play a major role in the choice of AC. Most physicians preferred DOACs even for patients with GI/GU cancers when patients had better ECOG scores and non-metastatic disease. However, these were also the same patients that were then more likely to have been exposed to additional risk factors for bleeding. BEs between DOACs and enoxaparin were similar and, between the DOACs, somewhat more favorable with apixaban than rivaroxaban. Randomized clinical trials, controlling for physician choice and bleeding risk factor, are necessary valid comparisons for the best choice of anticoagulation. Disclosures No relevant conflicts of interest to declare.
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Casperson, Shanon, Lisa Lanza, Eram Albajri e Jennifer Nasser. "Increasing Chocolate’s Sugar Content Enhances Its Psychoactive Effects and Intake". Nutrients 11, n. 3 (12 marzo 2019): 596. http://dx.doi.org/10.3390/nu11030596.
Testo completoAbstract (sommario):
Chocolate elicits unique brain activity compared to other foods, activating similar brain regions and neurobiological substrates with potentially similar psychoactive effects as substances of abuse. We sought to determine the relationship between chocolate with varying combinations of its main constituents (sugar, cocoa, and fat) and its psychoactive effects. Participants consumed 5 g of a commercially available chocolate with increasing amounts of sugar (90% cocoa, 85% cocoa, 70% cocoa, and milk chocolates). After each chocolate sample, participants completed the Psychoactive Effects Questionnaire (PEQ). The PEQ consists of questions taken from the Morphine-Benzedrine Group (MBG), Morphine (M,) and Excitement (E) subscales of the Addiction Research Center Inventory. After all testing procedures, participants completed the Binge Eating Scale (BES) while left alone and allowed to eat as much as they wanted of each of the different chocolates. We found a measurable psychoactive dose–effect relationship with each incremental increase in the chocolate’s sugar content. The total number of positive responses and the number of positive responses on the E subscale began increasing after tasting the 90% cocoa chocolate, whereas the number of positive responses on the MBG and M subscales began increasing after tasting the 85% cocoa chocolate sample. We did not find a correlation between BES scores and the total amount of chocolate consumed or self-reported scores on the PEQ. These results suggest that each incremental increase in chocolate’s sugar content enhances its psychoactive effects. These results extend our understanding of chocolate’s appeal and unique ability to prompt an addictive-like eating response.
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NEL, ANDRÉ. "The second genus of the extinct dragonfly family Urolibellulidae from the Eocene Green River Formation (Odonata, Anisoptera: Cavilabiata)". Palaeoentomology 3, n. 1 (26 febbraio 2020): 050–53. http://dx.doi.org/10.11646/palaeoentomology.3.1.7.
Testo completoAbstract (sommario):
If the oldest record of the anisopteran ‘libelluloid’ group Anauriculida Bechly, 1996 goes to the Cretaceous (Fleck et al., 1999; Kohli et al., 2016), its extant families are scarce or even absent before the Eocene. Nevertheless, the Anauriculida were already rather diverse during Eocene with a Libellulidae in the earliest Eocene (Fleck et al., 2000), and the extinct monotypic family Urolibellulidae in the middle Eocene Green River Formation (Zeiri et al., 2015). Crown Libellulidae become more and more frequent and diverse during Oligocene, and even dominate the dragonfly fauna in some outcrops (Céreste, Rott, Aix-en-Provence, Bes-Konak) (Nel & Paicheler, 1993). Thus any discovery in the Paleocene–Eocene of a new fossil related to these families is welcome. Here we describe a complete hindwing of this kind from the Green River Formation in Colorado.
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Sutiyarsih, Emy, e Sr Felisitas A Sri S. "Efektifitas Emotional Freedom Technique (EFT) Terhadap Penurunan Tingkat Depresi Pada Lansia". Jurnal Ilmu Kesehatan 6, n. 1 (29 novembre 2017): 01. http://dx.doi.org/10.32831/jik.v6i1.145.
Testo completoAbstract (sommario):
Depression in eldery couldn’t be easily detected because physical complaint was more often than emotional complaint. In severe case, depression could cause suicidal behaviour (Irawan, 2013). Therefore, elderly need assistance to deal with depression, and Emotional Freedom Technique (EFT) is one of the solution. Research design is pre-experimental design, using pre-test and post-test design. Before intervention, Geriatric Depression Scale test were given to one group of elder people. EFT intervention were given two times for four weeks, and Geriatric Depression Scale test were tested after intervention. Population was elder people who fulfill inclusion criterias, and 30 elderly were obatained. The significancy result was 0,000 (α = 0,05), it could be inferred that EFT has a strong relationship to depression scale. EFT could significantly reduce depression scale in elderly, so it can bes used effectively.
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Obradovic, Borislav, Dejan Madic, Zoran Milosevic, Nebojsa Maksimovic, Milena Mikalacki e Branka Kovacev-Zavisic. "Body composition and bone mineral density of prepubertal boys involved in different kinesiologic treatments". Medical review 62, n. 1-2 (2009): 23–26. http://dx.doi.org/10.2298/mpns0902023o.
Testo completoAbstract (sommario):
Introduction. It is well known that physical activity has an anabolic effect on the bone tissue. But there is a lack of information about the effect of intensive physical activity in childhood, particularly at the prepubertal stage. The type, frequency, intensity, and duration of activity that best produce the desired increases in mass and strength of human bones have not yet been well determined. Material and methods. To examine the influence of different kinesiological treatments on body composition and bone mineral density we studied a group of prepubertal boys at the starting phase of their peak bone mass acquisition. 90 healthy prepubertal boys took part in this study. The sport group consisted of 28 swimmers (aged 10.80.8) and 32 soccer players (aged 10.70.5), who had been training their chosen high-level sport activity for at least 1 year (8-12h per week for swimmers, 10-15h per week for soccer players). 30 boys (aged 11.2?0.7) doing 1.5h per week of physical activity in school served as a control group. Bone mineral density measurements of the left and right calcaneus were done by ultrasound densitometer 'Sahara'. The body composition was assessed by Body Fat Analyser 'BES 200 Z'. Results. There were significant differences between soccer players and control group as regards fat mass and bone mineral density (p<.01). Besides, significant differences were determined between a group of swimmers and control group as regads fat mass (p<.03), while the differences in bone mineral density were not very obvious (p<.67).
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Song, Yifan, Yun Chai, Kai Xu e Puyu Zhang. "Functional polyurethane nanomicelle with pH-responsive drug delivery property". e-Polymers 18, n. 5 (25 settembre 2018): 409–17. http://dx.doi.org/10.1515/epoly-2018-0030.
Testo completoAbstract (sommario):
AbstractA new functional pH-responsive polyurethane-based nanomicelle has been developed with BES-Na as the functional monomer, the buffering agent with tertiary amine, and sulfonic acid group was incorporated into the hydrophilic shell as the functional agent, which resulted in polyurethane nanosystem with pH-sensitive property. Folic acid (FA) was chosen as model hydrophobic drug to evaluate the loading and pH-triggered release of the PU micelles in vitro drug loading and release. The drug loading content (LC) and the encapsulation efficiency (EE) for FA-loaded micelles in phosphate-buffered solutions were 7.68% and 27.72%, respectively, and the largest accumulative drug release percentages in pH 6.8 and pH 5.0 were 79.17% and 89.83% in 24 h, respectively. A facile and versatile approach has been provided for the design and fabrication of smart nanovehicles for effective drug delivery and opens a new thought in the design and fabrication of biodegradable polyurethanes for next generation of nanomicellar systems.
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Madic, Dejan, Borislav Obradovic, Miroslav Smajic, Jelena Obradovic, Dusan Maric e Ksenija Boskovic. "Status of bone mineral content and body composition in boys engaged in intensive physical activity". Vojnosanitetski pregled 67, n. 5 (2010): 386–90. http://dx.doi.org/10.2298/vsp1005386m.
Testo completoAbstract (sommario):
Background/Aim. It is well known that physical activity has an anabolic effect on bone tissue. But there is a lack of information about the effect of intensive physical activity in childhood, particularly at the prepubertal stage. To examine the influence of training on body composition and bone mineral density we have studied a group of prepubertal soccer players as well as a group of inactive prepubertal boys at the starting phase of their peak bone mass acquisition. Methods. A total of 62 healthy prepubertal boys took part in this study. They were divided into two groups. The first one consisted of 32 soccer players (aged 10.7 ? 0.5 years), who had been playing football for at least 1 year (10-15 h per week). The second group a control group 30 boys (aged 11.2 ? 0.7 years) doing 1.5 h per week physical activity at school. Body composition was assessed by a Body Fat Analyzer 'BES 200 Z'. Bone mineral density measurements of the left and the right calcaneus were done by using ultrasound densitometer 'Sahara' (Hologic, Inc., MA, USA). Results. There were significant differences between soccer players and the control group in fat mass (p = 0.01). Besides, a significant difference was determined between the group of athletes and the control group in bone mineral density of both calcaneal bones (p = 0.01). Conclusion. The results of this study confirm the significant effects of physical activity on reducing body mass and increasing bone density. Considering that football training can be very easily implemented in the broader population of children and young people, which does not apply to many other sports, it should be used more in the prevention of obesity and osteoporosis.
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Yaish, Hassan M., Kate Khair, Mario von Depka, Maria Sol Cruz, Sylvia Werner, Sigurd Knaub e George M. Rodgers. "Observational Study on Safety and Efficacy of Factor Replacement Therapy in the Management of Von Willebrand Disease Patients - Results from an Ongoing Study with a VWF/FVIII Concentrate". Blood 128, n. 22 (2 dicembre 2016): 4968. http://dx.doi.org/10.1182/blood.v128.22.4968.4968.
Testo completoAbstract (sommario):
Abstract Introduction and Objective Prospective surveillance studies are a useful tool to monitor drug safety and efficacy in the post-approval period and provide treaters and caregivers with real-life information about von Willebrand disease (VWD) treatment. This ongoing study aims to demonstrate consistency of safety and efficacy data of a VWF/FVIII concentrate with a 1:1 ratio (wilate®) used in routine clinical practice with data obtained in previous clinical studies. Methods This non-interventional post-marketing surveillance study was designed to document the safety, tolerability, and efficacy of a 1:1 VWF/FVIII concentrate in the prophylaxis and treatment of bleeding, as well as in the perioperative bleeding management in VWD patients. Treatment regimens and dosages were at the discretion of the investigators. The primary endpoints were tolerability assessment on a 3-point verbal rating scale and the incidence of investigator reported adverse drug reactions (ADRs). Additionally, the efficacy was assessed using a pre-defined 4-point haemostatic scale for on-demand treatment and surgeries, and the frequency of breakthrough bleeding events (BEs) for prophylaxis. Results Eighty-nine patients qualified as safety population, having received at least one infusion of the VWF/FVIII concentrate. Tolerability was rated 'excellent' for 4261/4450 (96%) assessed infusions. No development of clinically relevant VWF inhibitors or thrombotic events occurred. ADRs were reported in 6 of 89 patients (6.7%). The efficacy population comprised 47 patients undergoing 74 surgeries, 22 patients treated on-demand for 93 BEs, 12 patients on continuous prophylactic treatment, and 4 patients treated for 20 menstrual BEs. Some patients were assessed in more than one treatment group. 100% of rated bleeds in patients on on-demand treatment were assessed as 'excellent/good', receiving a mean total dose per BE of 111.4 (+/-69.78) IU/kg. Of the 44 minor and 31 major surgeries, 73 (99%) were rated as 'excellent/good' efficacy and one (1%) as 'moderate'. Mean dose of VWF/FVIII concentrate used was 78.6 (+/-126.16) IU/kg and 132.4 (+/-102.71) IU/kg for minor and major surgeries, respectively. Patients on continuous prophylaxis received a mean of 111.4 (+/-69.78) IU/kg in a mean of 2.4 (+/-0.86) infusions per week and experienced a median annualized bleeding rate of 2.3 (mean 3.3±5.6; range 0-19.7) for spontaneous bleeds and 2.5 (mean 4.8±6.2; range 0-19.7) for all types of bleeds. Efficacy for menstrual bleeding was rated as excellent or good in 100% of rated episodes (16/20). Conclusion The data confirm the safety, tolerability and efficacy of the 1:1 VWF/FVIII concentrate in the treatment of VWD patients in routine clinical conditions. Disclosures Yaish: Octapharma: Other: Study investigator. Khair:Pfizer: Research Funding; NovoNordisk: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Baxalta, now part of Shire: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Study Investigator, Research Funding; Octapharma: Consultancy, Equity Ownership, Honoraria, Membership on an entity's Board of Directors or advisory committees, Other: Study Investigator, Patents & Royalties, Research Funding, Speakers Bureau; Sobi/Biogen: Research Funding. von Depka:Octapharma: Other: Study Investigator, Speakers Bureau. Cruz:Octapharma: Other: Study Investigator. Werner:Octapharma: Employment. Knaub:Octapharma: Employment. Rodgers:Octapharma: Other: Study Investigator.
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Allsop, Bradley, e Ben Kisby. "The “Youthquake” in British Politics: Myth or Reality?" Societies 9, n. 4 (29 settembre 2019): 68. http://dx.doi.org/10.3390/soc9040068.
Testo completoAbstract (sommario):
This article explores whether the past few years have witnessed what can accurately be described as a “youthquake” in British politics, following the candidature and election of Jeremy Corbyn as leader of the Labour Party. It argues that the British Election Study team, who argue that we witnessed “tremors but no youthquake”, fail to advance a convincing case that turnout did not significantly increase among the youngest group of voters in the 2017 general election in the UK, as compared to the previous election. The article explains why their rejection of the idea of a youthquake having occurred is problematic, focusing on the limitations of the BES data, the team’s analysis of it and the narrowness of their conception of what the notion of a “youthquake” entails. This article argues that there is other evidence suggestive of increased youth engagement in politics, both formal and informal, and that some social scientists have failed to spot this due to an insufficiently broad understanding of both “politics” and “youth”. The article concludes that vital work needs to be done to better conceptualise and measure the political experiences, understandings and actions of young people, which are not adequately captured by current methods.
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GARCIA, FRANCISCO HITA, e BRIAN L. FISHER. "The ant genus Tetramorium Mayr (Hymenoptera: Formicidae) in the Malagasy region—taxonomy of the T. bessonii, T. bonibony, T. dysalum, T. marginatum, T. tsingy, and T. weitzeckeri species groups". Zootaxa 3365, n. 1 (4 luglio 2012): 1. http://dx.doi.org/10.11646/zootaxa.3365.1.1.
Testo completoAbstract (sommario):
The taxonomy of the T. bessonii, T. bonibony, T. dysalum, T. marginatum, T. tsingy, and T. weitzeckeri species groups isrevised. A total of 33 species is treated, of which 27 are newly described and one is raised to species status. The T.weitzeckeri group contains the single species T. humbloti Forel, which is of Afrotropical origin and the only representativeof the group in the Malagasy region. The species T. bessonii Forel, T. dysalum Bolton, T. marginatum Forel, and T. stein-heili Forel, which were originally members of the T. weitzeckeri group, are now placed in other groups. Tetramorium bes-sonii is the core species of the T. bessonii group, which also contains the four newly described species T. artemis sp. n., T.malagasy sp. n., T. ryanphelanae sp. n., T. wardi sp. n., and T. orientale Forel stat. n., which was a junior synonym of T.bessonii but is now raised to species rank. The T. dysalum group is a moderately-sized group with ten species, of whichonly T. dysalum and T. steinheili were previously known; the other eight species are all newly described. The newly described species in this group are: T. ambatovy sp. n., T. macki sp. n., T. mallenseana sp. n., T. orc sp. n., T. robitika sp. n.,T. sargina sp. n., T. yammer sp. n., and T. vohitra sp. n. A lectotype and several paralectotypes of T. steinheili are desig-nated. Tetramorium marginatum is the central species of the T. marginatum group, which also includes the five newly de-scribed species T. valky sp. n., T. hector sp. n., T. norvigi sp. n., T. shamshir sp. n., and T. silvicola sp. n. The T. bonibonyand T. tsingy groups represent completely new groups that consist entirely of previously unknown, undescribed species.The first group holds the new species T. bonibony sp. n., T. kali sp. n., T. sada sp. n., T. nosybe sp. n., T. olana sp. n., T.popell sp. n., and T. trafo sp. n. and T. vony sp. n. The last group, the T. tsingy group, only contains the two species T. tyrionsp. n. and T. tsingy sp. n., both among the rarest Tetramorium species in Madagascar. All groups are fully revised withillustrated species-level identification keys, and all species are described/re-described and illustrated with high qualitymontage images. In addition, the current status of the Malagasy Tetramorium species groups is discussed and further modifications are proposed.
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Yalnızoğlu Çaka, Sinem, Sümeyra Topal, Tijen Nemut e Nursan Çınar. "Relationship between alexithymia and empathy in nursing and midwifery studentsHemşirelik ve ebelik öğrencilerinde aleksitimi ile empati arasındaki ilişki". Journal of Human Sciences 15, n. 2 (24 maggio 2018): 996. http://dx.doi.org/10.14687/jhs.v15i2.5285.
Testo completoAbstract (sommario):
Aim: This study was carried out to determine the relationship between alexithymia and empathy in nursing and midwifery students. Method: This descriptive, correlational and cross-sectional study was performed 240 students who volunteered to participate in the study on the date during which data were collected studying at the nursing and midwifery department of the Faculty of Health Sciences of a state university during the 2016-2017 Spring Semester. Data were collected using the Personal Information Form, the Basic Empathy Scale (BES) and the Toronto Alexithymia Scale (TAS-20). Frequency, percentage, mean, Mann-Whitney U test for binary groups, Kruskal-Wallis H Test and Spearman correlation analysis test for more than two groups were used in the evaluation of data. Findings: The average age of 240 students who participated in the study was 21.72±1.30 years, and 66.3% of them (n=159) were nursing students while 33.7% of them (n=81) were midwifery students. When the averages of the TAS-20 scores were examined, it was determined that 15.4% (n=37) of the students had a score of 61 or more and included alexithymic group. There was a significant negative relationship between the BES and TAS-20 (r=-.167, p=.010). Conclusion: It is observed that there is a negative relationship between students' alexithymia and empathy and that individuals without alexithymia tendency have higher empathy developing skills. Extended English summary is in the end of Full Text PDF (TURKISH) file. ÖzetAmaç: Bu araştırma, hemşirelik ve ebelik bölümü öğrencilerinde aleksitimi ile empati arasındaki ilişkiyi belirlemek amacıyla yapıldı. Yöntem: Tanımlayıcı, ilişki arayıcı ve kesitsel nitelikte yapılan çalışma, 2016-2017 Bahar Yarıyılı’nda verilerin toplandığı tarihte çalışmaya katılmaya gönüllü 240 öğrenci ile gerçekleştirildi. Veriler; Kişisel Bilgi Formu, Temel Empati Ölçeği (TEÖ) ve Toronto Aleksitimi Ölçeği (TAÖ-20) kullanılarak toplandı. Verilerin değerlendirilmesinde; frekans, yüzde, ortalama, ikili gruplarda Mann Whitney U Testi, ikiden fazla gruplarda Kruskal Wallis-H testi ve Spearmen korelasyon analiz testi kullanıldı. Bulgular: Araştırmaya katılan 240 öğrencinin yaş ortalamaları 21.72±1.30, %66.3’ü (n=159) hemşirelik ve %33.7’si (n=81) ebelik öğrencisi idi. TAÖ-20 puan ortalamaları incelendiğinde, öğrencilerin %15.4’ünün (n=37) 61 ve üstü puan alarak aleksitimik gruba dahil olduğu saptandı. TEÖ ve TAÖ-20 ölçekleri arasında zıt yönde anlamlı düzeyde bir ilişki olduğu saptandı (r=-.167, p=.010). Sonuç: Öğrencilerin aleksitimi ile empati arasında zıt yönde bir ilişki olduğu, aleksitimi eğilimi olmayan bireylerin empati kurma yeteneklerinin daha yüksek olduğu görülmektedir.
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Urban-Mead, Katherine R. "Predictability of bee community composition after floral removals differs by floral trait group". Biology Letters 13, n. 11 (novembre 2017): 20170515. http://dx.doi.org/10.1098/rsbl.2017.0515.
Testo completoAbstract (sommario):
Plant–bee visitor communities are complex networks. While studies show that deleting nodes alters network topology, predicting these changes in the field remains difficult. Here, a simple trait-based approach is tested for predicting bee community composition following disturbance. I selected six fields with mixed cover of flower species with shallow (open) and deep (tube) nectar access, and removed all flowers or flower heads of species of each trait in different plots paired with controls, then observed bee foraging and composition. I compared the bee community in each manipulated plot with bees on the same flower species in control plots. The bee morphospecies composition in manipulations with only tube flowers remaining was the same as that in the control plots, while the bee morphospecies on only open flowers were dissimilar from those in control plots. However, the proportion of short- and long-tongued bees on focal flowers did not differ between control and manipulated plots for either manipulation. So, bees within some functional groups are more strongly linked to their floral trait partners than others. And, it may be more fruitful to describe expected bee community compositions in terms of relative proportions of relevant ecological traits than species, particularly in species-diverse communities.
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van Vugt, Eveline, Jessica Asscher, Jan Hendriks, Geert Jan Stams, Catrien Bijleveld e Peter van der Laan. "Assessment of Moral Judgment and Empathy in Young Sex Offenders". International Journal of Offender Therapy and Comparative Criminology 56, n. 7 (23 agosto 2011): 986–96. http://dx.doi.org/10.1177/0306624x11420083.
Testo completoAbstract (sommario):
Professional decision making in forensic clinical practice may have lifelong consequences for offenders. Although information on moral development is important for prediction of reoffending and referral to adequate treatment, conclusions regarding moral development are still largely based on unstructured clinical judgment instead of assessment instruments. For this study, the authors examined to what extent unstructured clinical judgment of both moral judgment and victim empathy concurred with test results in a group of young sex offenders. Moral judgment was measured with the Sociomoral Reflection Measure–Short Form (SRM-SF), whereas victim empathy was measured with an extended version of the Basic Empathy Scale (BES). No significant associations were found between clinical judgment of moral judgment and the mean scores on the SRM-SF. However, clinical judgment of victim empathy was significantly associated with victim empathy on the Victim Empathy Scale but not consistently in the expected direction. Juvenile sex offenders, who were judged by clinicians to show little victim empathy, displayed lower mean scores on the Victim Empathy Scale than juvenile sex offenders who were evaluated to lack victim empathy or to have intact victim empathy. This study showed unstructured clinical judgment of moral development not to concur with test results. To improve decision-making processes regarding moral development, clinicians are advised to rely on instruments that assess moral development to inform clinical judgment. Further research is needed to examine which predictions are more accurate and to establish the predictive validity of moral development evaluations.
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Hsu, Jane Lu, Rainbow Tsai-Ling Hung e Melchior Antoine. "Investigating the Linkages between BMI, Body Image, and SATAQ among Young Asian Females". International Journal of Environmental Research and Public Health 18, n. 14 (13 luglio 2021): 7460. http://dx.doi.org/10.3390/ijerph18147460.
Testo completoAbstract (sommario):
Sociocultural attitudes toward appearance and its linkage to body mass index (BMI) and body image is a relationship worth studying, especially in Asia, where the idealization of thinness can be prominent. The Sociocultural Attitudes Toward Appearance Questionnaire (SATAQ) developed by Heinberg et al. in 1995 was used in this study to examine whether these beliefs have been internalized. Furthermore, the Body Esteem Scale (BES) was used to quantify body image. The formal in-person survey was administered in Taipei, Taiwan. There were 301 valid samples out of 330 surveyed respondents. To enhance the representativeness of the samples, a stratified sampling technique was applied to generate survey data with valid samples following gender and age distributions of the population between the ages of 14 and 28. The internalization dimension represented how strongly the respondents considered the importance of the socially accepted concept of appearance based on personal perceived social norms. The other dimension, awareness, represented the sociocultural pressures from the outside world, such as from the image of slimness illustrated in the media or group, in comparison to personal beliefs. Our results demonstrated that respondents with above-normal BMIs internalized the socially preferred standards of thinness more than respondents with normal or under-normal BMIs. Furthermore, results also revealed, overall, a negative relationship between SATAQ and body image and between body image and BMI. The study highlights the need to emphasize “fitness over thinness” to help improve negative body image among young Asian females.
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Tanizaki, Yuya, e Tetsuo Hatsuda. "Multi-regulator functional renormalization group for many-fermion systems". International Journal of Modern Physics E 26, n. 01n02 (gennaio 2017): 1740027. http://dx.doi.org/10.1142/s0218301317400274.
Testo completoAbstract (sommario):
We propose a method of multi-regulator functional renormalization group (MR-FRG) which is a novel formulation of functional renormalization group with multiple infrared (IR) regulators. It is applied to a two-component fermionic system with an attractive contact interaction to study crossover phenomena between the Bardeen–Cooper–Schrieffer (BCS) phase and the Bose–Einstein condensation (BEC) phase. To control both the fermionic one-particle excitations and the bosonic collective excitations, IR regulators are introduced, one for the fermionic two-point function and another for the four-fermion vertex. It is shown that the Nozières–Schmitt-Rink (NSR) theory, which is successful to capture qualitative features of the BCS–BEC crossover, can be derived from MR–FRG. Some aspects of MR-FRG to go beyond the NSR theory are also discussed.
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Vedmed, I. V., V. I. Sheremeta e V. G. Kaplunenko. "MELLIFEROUS CAPACITY OF BEE FAMILIES DEPENDING ON THE QUALITY OF QUEEN BEES, DERIVED WITH USING OF BIOLOGICALLY ACTIVE FEEDING". Animal Breeding and Genetics 51 (28 marzo 2018): 296–302. http://dx.doi.org/10.31073/abg.51.40.
Testo completoAbstract (sommario):
An experiment was conducted in order to detect the influence of quality of queen bees of the Carpathian bee breed derived with using of biologically active substances on melliferous capacity of bee family, it was formed two experimental and control groups of twenty-five breed of bees. Bees breeds formed in June by the generally accepted rules were used. For the formation of group, analogical couples of bees breeds in strength, the number of sealed brood, honey and bee cerago were taken.
The best queen bees’ sisters by development obtained from spring 2015 were sat to the experimental group. It means that they were genotype analogues and analogical couples by weight and body length. Queen bees derived from queen bees families which were fed with biologically active feeding Apistimulin BM and Nanostimulin were introduced to the first and second research groups. Queen bees derived from queen bees families which were fed only with sugar syrup were introduced into breeds of control group.
Introducing queen bees in breeds was carried out by using conventional method of Titov’s cage. The experimental bee families were in the beehives of the similar construction in equal conditions of care and feeding. Bee families were taken to honey harvest of linden and sunflower during the season. After finishing of honey harvest from each plant, pumping honey was conducted. Determination of the amount received from each of honey bee families was performed by the method of conducting experiments in beekeeping.
The influence of queen bees quality on melliferous capacity was judged by indicators of biometric processing of data from the output of trade honey during the season 2015, both separately for each breeds and overall.
Honey harvest of linden from June 26 to July 5 was held under very unfavourable weather conditions for the allocation of nectar caused by high temperatures. Also unfavourable weather conditions for honey harvest were during sunflower blooming from July 19 to August 11. During flowering sunflowers, especially in the beginning, there were heavy rains, with the air temperature significantly reduced, and since the middle to the end of honey harvest it has become too high. All climatic factors influenced the quality and quantity of honey harvest.
Analysis of the data showed that bees breeds formed on the basis of queen bees derived by using biologically active substances had more honey harvest than queen bees derived under usual conditions of feeding with sugar syrup. Thus, during honey harvest of linden, bees breeds of research groups have brought significantly more marketable honey by 16.4% and 51.5% than in the control.
The best result was obtained in the first experimental group formed by the queen bees derived by using stimulating bioactive feeding Apistimulin BM. The results of this group were 51.5% and 23.2% higher than in the control group and second group and received an average 14.71 kg of honey of bee family. Bees breeds of the second experimental group increased honey harvest by 16.4% that is a good result for increasing the output of marketable honey in the apiary.
The first experimental group had the lowest coefficient of variability, which indicates the similarity of queen bees and positive impact on their quality of honey harvest. The greatest individual features of queen bees were shown in families formed on the basis of queen bees derived by using stimulating bioactive feeding Nanostimulin. This group had the highest coefficient of variability.
During honey harvest of sunflower, the number of honey exceeded the indicators of the control ones by 17.5% and 52.4%. The smallest effect was manifested in families of the second experimental group and was 17.5%. The largest melliferous capacity was showed by bee families of the first group and it was 52.4% higher, in average 16.78 kg of honey per each family.
General results of marketable honey production by research bee families have confirmed significant influence of the quality of queen bees on the honey harvest. Thus, during the season 2015, the first and second research groups of bee families gathered 52% and 17% honey higher than the control ones.
So, developed biotechnological method, the essence of which is feeding queen bees families with the bioactive feeding in the embryonic period, provided high-quality queen bees whose families under adverse weather conditions for honey harvest had the best melliferous capacity.
It was established that bee families formed by using queen bees derived from queen bees families which were fed with bioactive feeding Nanostimulin and ApistimulinBM had 17% and 52% higher melliferous capacity under adverse weather conditions during honey harvest. Melliferous capacity of bee families depends upon the individual productive qualities of queen bees. At that, queen bees derived by using feeding ApistimulinBM are the most similar and their families have higher melliferous capacity than derived by using Nanostimulin and by generally accepted method.
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Sokół, Rajmund, e Maria Michalczyk. "Detection of Nosema spp. in worker bees, pollen and bee bread during the honey flow season". Acta Veterinaria Brno 85, n. 3 (2016): 261–66. http://dx.doi.org/10.2754/avb201685030261.
Testo completoAbstract (sommario):
Nosema apis and Nosema ceranae are responsible for nosemosis in the honey bee (Apis mellifera). The aim of the study was to identify Nosema spp. during the honey flow season in bee colonies, for co-infection or no infection with Nosema apis/Nosema ceranae. Hive bees, forager bees, pollen grains brought by them, and bee bread were analysed. In the infected group, 12 of 30 samples of hive bees were infected with Nosema ceranae, 7 were co-infected, 3 were infected with Nosema apis. In samples of forager bees, 21 of 30 were co-infected, 8 were infected with Nosema ceranae. The analysis of pollen demonstrated that only 2 of 30 samples were infected with Nosema ceranae, 3 of 30 samples of bee bread were infected with Nosema ceranae, 3 were co-infected and 1 of 30 were infected with Nosema apis. In the uninfected group, 13 of 30 samples of hive bees were co-infected, 2 were infected with Nosema ceranae. In the forager bees group, 12 of 30 samples were co-infected, 2 were infected with Nosema ceranae. Only 1 pollen sample was infected with Nosema ceranae and 1 was co-infected, 2 of 30 samples of bee bread were co-infected, 2 were infected with Nosema ceranae. The study demonstrated that during the honey flow season, infection by microsporidian species occurs mainly in forager bees. Pollen and bee bread may be a source of spores mainly at the beginning of the honey flow season.
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LIAKOS (Β. ΛΙΑΚΟΣ), B. "Investigation on the relationship between population synthesis of the honeybee stocks reared in Crete and their resistance to the tracheal mite Acarapis woodi, Rennie". Journal of the Hellenic Veterinary Medical Society 53, n. 1 (31 gennaio 2018): 56. http://dx.doi.org/10.12681/jhvms.15359.
Testo completoAbstract (sommario):
The population synthesis of honey bee breeds reared in Crete by crossbreeding among the native race Apis mellifera adami, Ruttner, the Macedonian bee Apis mellifera macedonica, Ruttner, and the Italian bee Apis mellifera ligustica, Spinal, was determinated. The probable relationship between population synthesis and resistance to tracheal mite Acarapis woodi, Rennie, of these breeds was also investigated. Samples of 50 bees were taken from 45 colonies of an apiary, infested with acarine disease, in which the bees showed a great diversity in their morphological characteristics and were examined as regards: a) the morphological and morphometric characteristics of the sampled bees, and b) the number of infested colonies, the prevalence, the unilateral or bilateral infection and the parasite intensity of thoracic tracheas, from every sample infested by Acarapis woodi. After examination the colonies were classified in four groups, according to morphological and morphometric characteristics that hade the majority of the bees in each sample: Group I, hybrids of Apis mellifera macedonica, group II, hybrids of Apis mellifera ligustica, group III, hybrids of "bright yellow" type of Apis mellifera ligustica, and group IV, diversiform hybrids. From the tracheas examinations it was detected that: the population synthesis affects the resistance of bee colonies. Bee colonies of group I showed the highest resistance. On the contrary, those of group III showed the lowest. Bee colonies of the two other groups showed relatively high resistance but less high than that of A. m. macedonica.
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Miao, Ming San, Qian Wang e Chao Hui Tang. "Study on Rapid Aging Model of Bees and the Effects of Bee Fengbingkang Mistura on Rapid Aging Model of Anima". Applied Mechanics and Materials 666 (ottobre 2014): 393–97. http://dx.doi.org/10.4028/www.scientific.net/amm.666.393.
Testo completoAbstract (sommario):
Preliminary study of the feasibility that regarding honey bees as a new experimental animals the feasibility, and the establishment of bee rapid aging animal model and discuss the effects of bee fengbingkang Mistura on rapid aging model Through the appropriate high temperature, vibration environment of hypoxia, manufacturing honey bees rapid aging animal models, after pretreatment 7 days, respectively making mode to the Fengbingkang Mixture of large and small doses, the positive control group, the model control group. We find that after making model 4 hours, SOD,GSH-PX in whole body homogenate in bees, versus the normal group dropped significantly, combined with histopathological observations made show that with increasing die time, the increase degeneration in honey bee brain and intestine, it shows that model is successful. We create bee rapid aging successfully, with an indication that this drug can combat the bee rapid aging environment, for the future development lay a foundation.
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Dvylyuk, I. I., e I. I. Kovalchuk. "The influence of citrates Ag and Cu on the lipid composition of the tissues of the honey bees body and bee bread under the condition of their added to the feeding in the spring period". Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 21, n. 91 (6 novembre 2019): 123–27. http://dx.doi.org/10.32718/nvlvet-a9122.
Testo completoAbstract (sommario):
Experimental data of the lipid composition of the honey bees and bee bread in the spring period under the conditions of feeding sugar syrup with Ag and Cu citrates are presented in the article. The studies were conducted on 3 groups of bee colonies, three bee colonies each. Control group (I) received sugar syrup at a concentration of 1:1 (1000 ml per week), experimental (II) group received under similar conditions with sugar syrup 0.2 mg of Argentum and 0.2 mg of Cuprum in citrate form. The third experimental group was fed with sugar syrup Ag and Cu citrates at doses of 0.5 mg each per 1000 ml of sugar syrup per week. The study was lasted 36 days. Samples of tissues of the whole organism of honey bees in the amount of 30–35 pieces were selected for the study. from each bee colony and bee bread to determine the total lipid content by the Folch method and their separate fractions: phospholipids, mono- and diacylglycerols, free cholesterol, non-esterified fatty acids, triacylglycerols, esterified cholesterol glycol cholesterol using thin layer chromatography using silica gel plates Sorbfil. According to the results of the research, we found intergroup differences of total lipid content in the tissues of whole organism of the honey bees and bee bread of experimental groups in comparison with the control group. Higher levels of phospholipids, esterified cholesterol, and lower levels of free cholesterol, mono- and diacylglycerols and triacylglycerols were found in the tissue of bees II and III of the experimental group. Introduction of Ag and Cu citrates into the components of bee feeding in the bee bread the level of phospholipids (P ˂ 0.01), mono and diacylglycerols (group III), triacylglycerols increased against the decrease of free cholesterol (P ˂ 0.05) and esterified cholesterol (P ˂ 0.01).
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SAYLOR, BEVERLY Z., JANICE M. POLING e WARREN D. HUFF. "Stratigraphic and chemical correlation of volcanic ash beds in the terminal Proterozoic Nama Group, Namibia". Geological Magazine 142, n. 5 (settembre 2005): 519–38. http://dx.doi.org/10.1017/s0016756805000932.
Testo completoAbstract (sommario):
At least twenty silicified volcanic ash beds have been identified in the Kuibis and Schwarzrand subgroups of the terminal Proterozoic Nama Group of Namibia. Nineteen of the Nama ash beds are in the Schwarzrand Subgroup in the Witputs subbasin. Two of these are in the siliciclastic-dominated lower part of the subgroup, which consists of the Nudaus Formation and Nasep Member of the Urusis Formation and comprises two depositional sequences. Identification and correlation of these ash beds are very well known based on stratigraphic position. Sixteen ash beds are contained within the carbonate-dominated strata of the Huns, Feldschuhhorn and Spitskop members of the Urusis Formation. These strata comprise four large-scale sequences and eighteen medium-scale sequences. Ash beds have been found in three of the large-scale sequences and seven of the medium-scale sequences. Correlations are proposed for these ash beds that extend over large changes in facies and stratal thickness and across transitions between the seaward margin, depocentre and landward margin of the Huns-Spitskop carbonate shelf. A study of whole rock and in situ phenocryst compositions was conducted to evaluate the feasibility of independently testing sequence stratigraphic correlations by geochemically identifying individual ash beds. Whole rock abundances of Al, Fe, Mg, K and Ti vary inversely with Si, reflecting variations in phenocryst concentration due to air fall and hydrodynamic sorting. These sorting processes did not substantially fractionate whole rock rare earth element abundances (REE), which vary more widely with Si. REE abundances are higher in samples of the Nudaus ash bed than in samples of the Nasep ash bed, independent of position in bed, phenocryst abundance, or grainsize, providing a geochemical means for discriminating between the two beds. Variations in the position of chondrite-normalized whole rock REE plots similarly support suspected correlations of ash beds between widely separated sections of the Spitskop Member. Abundances of Fe, Mg and Mn in apatite plot in distinct clusters for Spitskop ash beds that are known to be different and in clusters that overlap for ash beds suspected of correlating between sections. Abundances of REE in monazites differ for the Nudaus, Nasep and Spitskop ash beds in which these phenocrysts were identified. Multivariate statistical analysis provided a quantitative analysis of the discriminating power of different elements and found that whole rock abundances of Ge, Nb, Cs, Ba and La discriminate among the whole rock compositions of the Nudaus and Nasep ash beds and the Spitskop ash beds that are thought to correlate between sections. Each of the above geochemical signatures, by itself, is not definitive because the differences between beds are comparable to the variability within beds and because some signatures are shared by beds known to be different. Taken together, however, weight-of-evidence arguments based on multiple components and phases can successfully discriminate among Nama ash beds. Results from this study support sequence stratigraphic correlations of Spitskop ash beds that document stratal truncations and gaps in the record related to onlap and erosion.
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Spallone, Marco, e Pina Murè. "Strategic group lending for banks". Banks and Bank Systems 13, n. 1 (29 marzo 2018): 115–27. http://dx.doi.org/10.21511/bbs.13(1).2018.11.
Testo completoAbstract (sommario):
Credit institutions often refuse to lend money to small firms. Usually, this happens because small firms are not able to provide collateral to lenders. Moreover, given the small amount of required loans, the relative cost of full monitoring is too high for lenders. Group lending contracts have been viewed as an effective solution to credit rationing of small firms in both developing and industrialized countries. The aim of this paper is to highlight the potential of group lending contracts in terms of credit risk management. In particular, this paper provides a theoretical explanation of the potential of group lending programs in screening good borrowers from bad ones to reduce the incidence of non-performing-loans (NPL). This paper shows that the success of firms involved in selected group lending programs is due to the fact that co-signature is an effective screening device: more precisely, if lenders make a proper use of co-signature to screen good firms from bad ones, then only firms that are good ex-ante enter group lending contracts. So, the main argument of this paper is that well designed group lending programs induce good firms to become jointly liable, at least partially, with other good firms and discourage other – bad-firms to do the same. Specifically, co-signature is proven to be a screening device only in the case of a perfectly competitive bank sector.
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Amro, Abdulraouf, Mohamed Younis e Ayman Ghania. "Physiological Effects of Some Pollen Substitutes Diets on Caged Honey Bee Workers (Apis mellifera L.)". International Journal of Environment 9, n. 1 (8 febbraio 2020): 87–99. http://dx.doi.org/10.3126/ije.v9i1.27589.
Testo completoAbstract (sommario):
Nutritional value of four proteinaceous diets and their physiological effects on honey bee workers were evaluated under laboratory conditions. The tested diets were as follows: diet 1 – date (Phoenix dactylifera L.) syrup, skimmed milk powder and dried brewer's yeast, diet 2 – Fenugreek (Trigonella foenum-graecum L.), Turmeric (Curcuma longa L.) powders and dried brewer's yeast, diet 3 – chickpea (Cicer arietinum L.) flour, wheat germ and dried brewer's yeast and diet 4 - soybean meal, skimmed milk powder and dried brewer's yeast, beside a control group (bee bread). Caged Carniolan honey bee workers were used in the experiments. The consumption rate, workers longevity, development degree of hypopharyngeal glands (HPG), and weight of rectal contents were determined. The greatest consumption rate was recorded for the control group while the lowest one was recorded for diet 4. Feeding bees on diet 3 gave the longest longevity (LT50= 27.0 days) among the tested diets and as a second rank after bees in the control group (LT50 = 29.0 days) while diet 4 showed the lowest longevity (LT50 =20.5 days). The highest HPG development degree (3.78) was recorded for 9 days old bees in the control group, followed by diet 3 (3.24) while the lowest degree (2.14) was to diet 4. The weight of rectal contents of honey bee workers was 13.43, 16.03 and 16.12 mg/bee/3 days for diet 3, diet 1 and diet 2, respectively, suggesting the suitability of these diets to bees. In light of this study, diet 3 and 2 have the best physiological effects for bees with good nutritional values.