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Autore: Grafiati

Pubblicato: 25 maggio 2024

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1

Li, Yawen, Ming-Kuan Chyan, Donald K. Hamlin, Holly Nguyen, Eva Corey e D. Scott Wilbur. "Oxidation of p-[125I]Iodobenzoic Acid and p-[211At]Astatobenzoic Acid Derivatives and Evaluation In Vivo". International Journal of Molecular Sciences 23, n. 18 (13 settembre 2022): 10655. http://dx.doi.org/10.3390/ijms231810655.

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The alpha particle-emitting radionuclide astatine-211 (211At) is of interest for targeted radiotherapy; however, low in vivo stability of many 211At-labeled cancer-targeting molecules has limited its potential. As an alternative labeling method, we evaluated whether a specific type of astatinated aryl compound that has the At atom in a higher oxidation state might be stable to in vivo deastatination. In the research effort, para-iodobenzoic acid methyl ester and dPEG4-amino acid methyl ester derivatives were prepared as HPLC standards. The corresponding para-stannylbenzoic acid derivatives were also prepared and labeled with 125I and 211At. Oxidization of the [125I]iodo- and [211At]astato-benzamidyl-dPEG4-acid methyl ester derivatives provided materials for in vivo evaluation. A biodistribution was conducted in mice with coinjected oxidized 125I- and 211At-labeled compounds. The oxidized radioiodinated derivative was stable to in vivo deiodination, but unfortunately the oxidized [211At]astatinated benzamide derivative was found to be unstable under the conditions of isolation by radio-HPLC (post animal injection). Another biodistribution study in mice evaluated the tissue concentrations of coinjected [211At]NaAtO3 and [125I]NaIO3. Comparison of the tissue concentrations of the isolated material from the oxidized [211At]benzamide derivative with those of [211At]astatate indicated the species obtained after isolation was likely [211At]astatate.

2

Nagao, Y., M. Yamaguchi, S. Watanabe, N. S. Ishioka, N. Kawachi e H. Watabe. "Performance improvement of Compton imaging of astatine-211 by optimising coincidence time windows". Journal of Instrumentation 16, n. 12 (1 dicembre 2021): C12031. http://dx.doi.org/10.1088/1748-0221/16/12/c12031.

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Abstract Astatine-211 is one of the promising radioisotopes for targeted alpha therapy. Optimising treatment strategies as well as determining the suitability of a given agent for a particular patient requires to image the time-dependent distribution of the targeted radiotherapeutic agent both in tumours and in normal tissues. Since the biodistribution of astatine is different from that of iodine, imaging astatine-211 directly is essential. In the previous study of astatine-211 Compton imaging, random coincidence events due to polonium K-shell X-rays were dominant and seemed to cause saturation of counts. Thus optimisation of the coincidence time windows is important to reduce random coincidence events. In this study, we have optimised the coincidence time windows of a Compton camera and improved the sensitivity, noise and spatial resolution of astatine-211 imaging.

3

Wilbur, D. "[211At]Astatine-Labeled Compound Stability: Issues with Released [211At]Astatide and Development of Labeling Reagents to Increase Stability". Current Radiopharmaceuticalse 1, n. 3 (1 settembre 2008): 144–76. http://dx.doi.org/10.2174/1874471010801030144.

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4

CORSON, DALE R. "ASTATINE". Chemical & Engineering News 81, n. 36 (8 settembre 2003): 158. http://dx.doi.org/10.1021/cen-v081n036.p158.

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5

Meyer, Geerd-J. "Astatine". Journal of Labelled Compounds and Radiopharmaceuticals 61, n. 3 (22 febbraio 2018): 154–64. http://dx.doi.org/10.1002/jlcr.3573.

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6

Wilbur, D. Scott. "Enigmatic astatine". Nature Chemistry 5, n. 3 (20 febbraio 2013): 246. http://dx.doi.org/10.1038/nchem.1580.

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7

Sarr, Serigne, Julien Pilmé, Gilles Montavon, Jean-Yves Le Questel e Nicolas Galland. "Astatine Facing Janus: Halogen Bonding vs. Charge-Shift Bonding". Molecules 26, n. 15 (28 luglio 2021): 4568. http://dx.doi.org/10.3390/molecules26154568.

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The nature of halogen-bond interactions was scrutinized from the perspective of astatine, potentially the strongest halogen-bond donor atom. In addition to its remarkable electronic properties (e.g., its higher aromaticity compared to benzene), C6At6 can be involved as a halogen-bond donor and acceptor. Two-component relativistic calculations and quantum chemical topology analyses were performed on C6At6 and its complexes as well as on their iodinated analogues for comparative purposes. The relativistic spin–orbit interaction was used as a tool to disclose the bonding patterns and the mechanisms that contribute to halogen-bond interactions. Despite the stronger polarizability of astatine, halogen bonds formed by C6At6 can be comparable or weaker than those of C6I6. This unexpected finding comes from the charge-shift bonding character of the C–At bonds. Because charge-shift bonding is connected to the Pauli repulsion between the bonding σ electrons and the σ lone-pair of astatine, it weakens the astatine electrophilicity at its σ-hole (reducing the charge transfer contribution to halogen bonding). These two antinomic characters, charge-shift bonding and halogen bonding, can result in weaker At-mediated interactions than their iodinated counterparts.

8

Yagishita, Atsushi, Miho Katsuragawa, Shin’ichiro Takeda, Yoshifumi Shirakami, Kazuhiro Ooe, Atsushi Toyoshima, Tadayuki Takahashi e Tadashi Watabe. "Development and Utility of an Imaging System for Internal Dosimetry of Astatine-211 in Mice". Bioengineering 11, n. 1 (26 dicembre 2023): 25. http://dx.doi.org/10.3390/bioengineering11010025.

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In targeted radionuclide therapy, determining the absorbed dose of the ligand distributed to the whole body is vital due to its direct influence on therapeutic and adverse effects. However, many targeted alpha therapy drugs present challenges for in vivo quantitative imaging. To address this issue, we developed a planar imaging system equipped with a cadmium telluride semiconductor detector that offers high energy resolution. This system also comprised a 3D-printed tungsten collimator optimized for high sensitivity to astatine-211, an alpha-emitting radionuclide, and adequate spatial resolution for mouse imaging. The imager revealed a spectrum with a distinct peak for X-rays from astatine-211 owing to the high energy resolution, clearly distinguishing these X-rays from the fluorescent X-rays of tungsten. High collimator efficiency (4.5 × 10−4) was achieved, with the maintenance of the spatial resolution required for discerning mouse tissues. Using this system, the activity of astatine-211 in thyroid cancer tumors with and without the expression of the sodium iodide symporter (K1-NIS/K1, respectively) was evaluated through in vivo imaging. The K1-NIS tumors had significantly higher astatine-211 activity (sign test, p = 0.031, n = 6) and significantly decreased post-treatment tumor volume (Student’s t-test, p = 0.005, n = 6). The concurrent examination of intratumor drug distribution and treatment outcome could be performed with the same mice.

9

Dzhuzha, D., e S. Myasoyedov. "Radionuclide therapy with alpha-emitters". Radiation Diagnostics, Radiation Therapy, n. 4 (2019): 37–47. http://dx.doi.org/10.37336/2707-0700-2019-4-4.

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In this review the main streams of using alpha-emitters radium-223, actinium-225, bismuth-213, astatine-211 in complex treatment of malignant tumors are reviewed. The features of radiobiological actions of alpha-emission make its more effective in hundred times than beta-emission. The efficacy of this kind of radionuclide therapy does not dependent from chemoresistance and radioresistance to beta-emitters. The results of experimental and initial clinical investigation, which indicate on promising further investigations in this direction, were revealed. Key words: radionuclide therapy of malignant tumors, alpha-emitters, radium-223, actinium-225, bismuth-213, astatine-211.

10

Nemec, S. "Glomus intraradix effects on citrus rootstock seedling growth in various potting media". Journal of Agricultural Science 118, n. 3 (giugno 1992): 315–23. http://dx.doi.org/10.1017/s0021859600070684.

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SUMMARYFive potting media components mixed in various combinations and in various percentages of one with another (0, 14·3, 29, 42, 57, 71 and 100% by volume of the second component with the first) were inoculated with Glomus intraradix in six experiments. Seedlings of citrus rootstocks were grown from seed in these mixes. Sour orange in inoculated peat plus vermiculite, Astatula fine sand plus vermiculite, and peat plus Perlite® in all percentage combinations grew c. two- to threefold taller than noninoculated control plants. Up to twofold growth increases of sour orange occurred in vermiculite amended with wood shavings. The best evidence for fungus-mediated plant growth occurred in Astatula fine sand amended with 29–71% Perlite, and the roots in that combination had the highest percentage of infection. In another experiment in which Astatula fine sand was amended with up to 16% of an acid peat, ratios of inoculated rough lemon plant growth to controls decreased as the peat content in the medium increased. Top and root weight ratios of inoculated:control seedlings in the six experiments did not fit four simple linear models.

11

Graton, Jérôme, Seyfeddine Rahali, Jean-Yves Le Questel, Gilles Montavon, Julien Pilmé e Nicolas Galland. "Spin–orbit coupling as a probe to decipher halogen bonding". Physical Chemistry Chemical Physics 20, n. 47 (2018): 29616–24. http://dx.doi.org/10.1039/c8cp05690k.

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12

Bigourdan, Théo, Arnaud Cadiou, Arnaud Guertin e Ferid Haddad. "Discussions on liquid bismuth target use as an alternative for astatine-211 production". EPJ Web of Conferences 285 (2023): 09002. http://dx.doi.org/10.1051/epjconf/202328509002.

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Abstract (sommario):

Astatine-211 is an alpha emitter that has been identified as a good candidate for targeted alpha therapy. There is an increasing demand on this radionuclide. Very intense beam from linac being put in operation nowadays could be used to meet this demand. This document presents the design exploration of concepts of liquid bismuth targets dedicated to astatine-211 production. Three concepts are presented and analyzed: a capsule, a fluid loop and a windowless fluid loop. Structural and thermal sizing were performed using mechanical Finite Element models (ANSYS Workbench) and Computational Fluid Dynamic models (FLUENT). Production rates were assessed accordingly. Feasibility and expected performances are discussed in conclusion.

13

Galland, N., G. Montavon, J. Y. Le Questel e J. Graton. "Quantum calculations of At-mediated halogen bonds: on the influence of relativistic effects". New Journal of Chemistry 42, n. 13 (2018): 10510–17. http://dx.doi.org/10.1039/c8nj00484f.

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14

Garkushin, Ivan K., Olga V. Lavrenteva, Yana A. Andreeva e Karina R. Gilmanova. "Analytical description of the specific electric conductivity of halogenides KHal melts and its calculation for the KAt melt". Butlerov Communications 58, n. 6 (30 giugno 2019): 138–45. http://dx.doi.org/10.37952/roi-jbc-01/19-58-6-138.

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In this paper, the analytical description of the specific conductivity of the potassium halogenides melts KHal (Hal – F, Cl, Br, I) is presented. The analitical description is provided on dependence of the specific conductivity on the halogen order number ӕ = f(Z), the ionic radius of halogen-ion ӕ = f(r), the ionic potential ӕ = f(1/r), the electronegativity difference ӕ = f(∆χ) ((∆χ = χ (Hal) – χ(K)). The interrelation of a reduced property with an order number ӕ/Z = f(Z) is considered. According to the obtained analytical dependencies, the calculation of the value of the potassium astatide specific conductivity is given for temperatures above the melting point on 5, 10, 50, 75, 100, 150 и 200°, in literature Information for KAt absent. The calculation was carried out using comparative methods for calculating M.Kh. Karapetyan in the coordinates of "property-parameter" and "property-property." Least squares method was applied for processing the analytical description results with the choice of optimal dependencies on the maximum correlation coefficient and the minimum standard deviation. The analysis of the interrelation of the calculated numerical values with similar characteristics for NaAt и LiAt is presented. Comparison of the specific conductivity obtained numerical values of the astatide potassium melt showed good consistency with the values ӕ obtained from the straight line dependence ӕТпл+n = a∙ ӕТпл+5 (n = 10°…200°) and also with similar characteristics for lithium astatide and sodium astatide. The analytical calculation results allow to describe the temperature dependence of the potassium halogenides specific conductivity, including KAt. The calculation method can be used to describe the melts specific conductivity in the same type series of compounds of alkaline and alkaline-earth elements that make up electrolytes for chemical current sources.

15

Rossi, Elisa, Matteo De Santis, Diego Sorbelli, Loriano Storchi, Leonardo Belpassi e Paola Belanzoni. "Spin–orbit coupling is the key to unraveling intriguing features of the halogen bond involving astatine". Physical Chemistry Chemical Physics 22, n. 4 (2020): 1897–910. http://dx.doi.org/10.1039/c9cp06293a.

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16

Gouard, Sébastien, Catherine Maurel, Séverine Marionneau-Lambot, Delphine Dansette, Clément Bailly, François Guérard, Nicolas Chouin et al. "Targeted-Alpha-Therapy Combining Astatine-211 and anti-CD138 Antibody in a Preclinical Syngeneic Mouse Model of Multiple Myeloma Minimal Residual Disease". Cancers 12, n. 9 (22 settembre 2020): 2721. http://dx.doi.org/10.3390/cancers12092721.

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Despite therapeutic progress in recent years with the introduction of targeted therapies (daratumumab, elotuzumab), multiple myeloma remains an incurable cancer. The question is therefore to investigate the potential of targeted alpha therapy, combining an anti-CD138 antibody with astatine-211, to destroy the residual cells that cause relapses. A preclinical syngeneic mouse model, consisting of IV injection of 1 million of 5T33 cells in a KaLwRij C57/BL6 mouse, was treated 10 days later with an anti-mCD138 antibody, called 9E7.4, radiolabeled with astatine-211. Four activities of the 211At-9E7.4 radioimmunoconjugate were tested in two independent experiments: 370 kBq (n = 16), 555 kBq (n = 10), 740 kBq (n = 17) and 1100 kBq (n = 6). An isotype control was also tested at 555 kBq (n = 10). Biodistribution, survival rate, hematological parameters, enzymatic hepatic toxicity, histological examination and organ dosimetry were considered. The survival median of untreated mice was 45 days after engraftment. While the activity of 1100 kBq was highly toxic, the activity of 740 kBq offered the best efficacy with 65% of overall survival 150 days after the treatment with no evident sign of toxicity. This work demonstrates the pertinence of treating minimal residual disease of multiple myeloma with an anti-CD138 antibody coupled to astatine-211.

17

Roy, Kamalika, e Susanta Lahiri. "Production and separation of Astatine Radionuclides: Some new addition to Astatine Chemistry". Applied Radiation and Isotopes 66, n. 5 (maggio 2008): 571–76. http://dx.doi.org/10.1016/j.apradiso.2007.12.005.

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18

Zhou, Fengxiang, Yuan Liu, Zhaoxu Wang, Tian Lu, Qingyuan Yang, Yi Liu e Baishu Zheng. "A new type of halogen bond involving multivalent astatine: an ab initio study". Physical Chemistry Chemical Physics 21, n. 28 (2019): 15310–18. http://dx.doi.org/10.1039/c9cp02406a.

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19

Molina, B., J. R. Soto e J. J. Castro. "Halogen-like properties of the Al13 cluster mimicking astatine". Physical Chemistry Chemical Physics 20, n. 17 (2018): 11549–53. http://dx.doi.org/10.1039/c8cp00494c.

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20

Liu, Lu, Seyfeddine Rahali, Rémi Maurice, Cecilia Gomez Pech, Gilles Montavon, Jean-Yves Le Questel, Jérôme Graton, Julie Champion e Nicolas Galland. "An expanded halogen bonding scale using astatine". Chemical Science 12, n. 32 (2021): 10855–61. http://dx.doi.org/10.1039/d1sc02133h.

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Abstract (sommario):

Based on the halogen bonding between astatine monoiodide (AtI) and 16 Lewis bases, the newly established pKBAtI scale indicates that the halogen bond basicity of AtI follows the order C ≤ O ≤ S ≈ Se for the acceptor atomic site.

21

Toyoshima, Atsushi, e Atsushi Shinohara. "Nuclear Chemistry of Astatine (At)". RADIOISOTOPES 67, n. 10 (15 ottobre 2018): 461–69. http://dx.doi.org/10.3769/radioisotopes.67.461.

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22

Vaidyanathan, Ganesan, e Michael Zalutsky. "Astatine Radiopharmaceuticals: Prospects and Problems". Current Radiopharmaceuticalse 1, n. 3 (1 settembre 2008): 177–96. http://dx.doi.org/10.2174/1874471010801030177.

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23

R. Zalutsky, Michael, e Marek Pruszynski. "Astatine-211: Production and Availability". Current Radiopharmaceuticalse 4, n. 3 (1 luglio 2011): 177–85. http://dx.doi.org/10.2174/1874471011104030177.

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24

Lindegren, Sture, Tom Bäck, Stig Palm, Holger Jensen, Per Albertsson e Emma Aneheim. "Astatine-211: The Chemistry Infrastructure". Journal of Medical Imaging and Radiation Sciences 50, n. 4 (dicembre 2019): S94. http://dx.doi.org/10.1016/j.jmir.2019.11.081.

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25

Lindegren, Sture, Tom Bäck, Stig Palm, Holger Jensen, Per Albertsson e Emma Aneheim. "Astatine-211: The Chemistry Infrastructure". Journal of Medical Imaging and Radiation Sciences 50, n. 1 (marzo 2019): S24. http://dx.doi.org/10.1016/j.jmir.2019.03.076.

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26

Milesz, S., M. Jovchev, D. Schumann, V. A. Khalkin e M. Milanov. "The EDTA complexes of astatine". Journal of Radioanalytical and Nuclear Chemistry Letters 127, n. 3 (giugno 1988): 193–98. http://dx.doi.org/10.1007/bf02164864.

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27

Ostrowski, Sławomir, Agnieszka Majkowska-Pilip, Aleksander Bilewicz e Jan Cz Dobrowolski. "On AunAt clusters as potential astatine carriers". RSC Advances 7, n. 57 (2017): 35854–57. http://dx.doi.org/10.1039/c7ra05224c.

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Abstract (sommario):

To understand interactions between astatine atoms with gold clusters the Au_nAt and Au_nX clusters, n = 12 or 13, X = F, Cl, Br, and I, were calculated at the DFT level using basis sets with a quasi-relativistic pseudopotential.

28

Baran, Enrique J. "Vibrational Properties of Hydrogen Astatide, HAt". Zeitschrift für Naturforschung A 59, n. 3 (1 marzo 2004): 133–35. http://dx.doi.org/10.1515/zna-2004-0306.

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Abstract (sommario):

A number of theoretical studies on the bond characteristics of HAt, the heaviest hydrogen halide, have recently been reported. On the basis of these data the force constant, mean amplitudes of vibration and thermodynamic functions of this molecule have been calculated. Some comparisons with the related lighter hydracids are made.

29

Thornton, Brett, e Shawn Burdette. "Three more unsung women – astatine discovery". Nature 567, n. 7748 (marzo 2019): 311. http://dx.doi.org/10.1038/d41586-019-00929-w.

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30

Ünak, Turan. "Some microdosmetric data on Astatine-211". Applied Radiation and Isotopes 58, n. 1 (gennaio 2003): 115–17. http://dx.doi.org/10.1016/s0969-8043(02)00260-9.

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31

Sam Lemonick. "The puzzle and promise of astatine". C&EN Global Enterprise 98, n. 31 (17 agosto 2020): 22–24. http://dx.doi.org/10.1021/cen-09831-feature2.

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32

Hawkes, Stephen J. "Polonium and Astatine Are Not Semimetals". Journal of Chemical Education 87, n. 8 (agosto 2010): 783. http://dx.doi.org/10.1021/ed100308w.

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33

Takahashi, N., e H. Baba. "Anomalous solvent extraction behavior of astatine". Journal of Radioanalytical and Nuclear Chemistry 218, n. 1 (aprile 1997): 103–5. http://dx.doi.org/10.1007/bf02033983.

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34

Guminski, C. "The At-Hg (astatine-mercury) system". Journal of Phase Equilibria 16, n. 6 (dicembre 1995): 525. http://dx.doi.org/10.1007/bf02646723.

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35

Zegeye, Abebe. "Mulatu Astatke, Ethio-jazz maestro". Muziki 4, n. 1 (luglio 2007): 129–51. http://dx.doi.org/10.1080/18125980701754645.

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36

Cobb, L. M., A. Harrison e S. A. Butler. "Toxicity of Astatine-211 in the Mouse". Human Toxicology 7, n. 6 (novembre 1988): 529–34. http://dx.doi.org/10.1177/096032718800700602.

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Abstract (sommario):

The toxicity of the α particle emitting halogen astatine-211 was examined in male and female mice. Pathological changes were seen in mice killed at 14 days and/or at 56 days following a single injection of 61 kBq211 At per g body weight. The tissues affected, in order of severity were: spleen, lymph nodes, bone marrow, gonads, thyroid, salivary glands and stomach.

37

Nishinaka, I., K. Hashimoto e H. Suzuki. "Speciation of astatine reacted with oxidizing and reducing reagents by thin layer chromatography: formation of volatile astatine". Journal of Radioanalytical and Nuclear Chemistry 322, n. 3 (26 ottobre 2019): 2003–9. http://dx.doi.org/10.1007/s10967-019-06900-3.

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KACZMAREK, ŁUKASZ. "New records of and key to Tardigrada from Costa Rica". Zootaxa 177, n. 1 (3 aprile 2003): 1. http://dx.doi.org/10.11646/zootaxa.177.1.1.

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Abstract (sommario):

Moss samples collected near the research station “La Selva” on the edge of Costa Rican tropical rain forest has yielded three species of Tardigrada: Hypsibius pallidus Thulin, Astatumen trinacriae (Arcidiacono) and Macrobiotus polyopus Marcus. Another three unidentified species from the genus Macrobiotus were also found. All identified species are new for Costa Rica. A key to the identification of all known species from Costa Rica is given.

39

Ghalei, Mohammad, Parastoo Mahdi Khoshouei, Johan Vandenborre, Francois Guérard, Guillaume Blain, Mojtaba Zarei, Ferid Haddad e Massoud Fattahi. "Influence of radiolysis on astatine-211 chemistry". Nuclear Medicine and Biology 108-109 (maggio 2022): S142. http://dx.doi.org/10.1016/s0969-8051(22)00306-7.

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40

Lambrecht, Richard M., e Saed Mirzadeh. "Cyclotron isotopes and radiopharmaceuticals—XXXV astatine-211". International Journal of Applied Radiation and Isotopes 36, n. 6 (giugno 1985): 443–50. http://dx.doi.org/10.1016/0020-708x(85)90207-8.

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41

Kambali, I. "Calculated astatine-211 production yields for radioimmunotherapy". Journal of Physics: Conference Series 1116 (dicembre 2018): 032013. http://dx.doi.org/10.1088/1742-6596/1116/3/032013.

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42

Leimbach, D., S. Rothe, J. Sundberg e D. Hanstorp. "Determination of the electron affinity of astatine". Journal of Physics: Conference Series 1412 (gennaio 2020): 132024. http://dx.doi.org/10.1088/1742-6596/1412/13/132024.

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43

Pruszyński, M., A. Bilewicz, B. Wąs e B. Petelenz. "Formation and stability of astatide-mercury complexes". Journal of Radioanalytical and Nuclear Chemistry 268, n. 1 (aprile 2006): 91–94. http://dx.doi.org/10.1007/s10967-006-0129-2.

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44

Burke, D. G., H. Folger, H. Gabelmann, E. Hagebø, P. Hill, P. Hoff, O. Jonsson et al. "New neutron-rich isotopes of astatine and bismuth". Zeitschrift für Physik A Atomic Nuclei 333, n. 2 (giugno 1989): 131–35. http://dx.doi.org/10.1007/bf01565142.

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45

Brown, I. "Astatine-211: Its possible applications in cancer therapy". International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes 37, n. 8 (gennaio 1986): 789–98. http://dx.doi.org/10.1016/0883-2889(86)90273-x.

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46

Kassis, A. I., C. R. Harris e S. J. Adelstein. "The in Vitro Radiobiology of Astatine-211 Decay". Radiation Research 105, n. 1 (gennaio 1986): 27. http://dx.doi.org/10.2307/3576722.

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47

Mirzadeh, Saed, e Richard M. Lambrecht. "Process for producing astatine-211 for radiopharmaceutical use". Environment International 14, n. 1 (gennaio 1988): II. http://dx.doi.org/10.1016/0160-4120(88)90389-3.

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48

Mirzadeh, Saed, e Richard M. Lambrecht. "Process for producing astatine-211 for radiopharmaceutical use". International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology 15, n. 2 (gennaio 1988): i. http://dx.doi.org/10.1016/0883-2897(88)90095-5.

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49

Ikeda, Hayato, Yoshihiko Hayashi, Naruto Takahashi, Tadashi Watabe, Yasukazu Kanai, Atsushi Shinohara, Hiroki Kato, Hiroshi Watabe, Eku Shimosegawa e Jun Hatazawa. "Application of astatine-210: Evaluation of astatine distribution and effect of pre-injected iodide in whole body of normal rats". Applied Radiation and Isotopes 139 (settembre 2018): 251–55. http://dx.doi.org/10.1016/j.apradiso.2018.05.021.

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50

Yennello, S. J., L. A. McIntosh, J. D. Burns, E. E. Tereshatov, G. Tabacaru, L. McCann, S. Schultz et al. "Advances in 211At production at Texas A&M University". EPJ Web of Conferences 252 (2021): 03002. http://dx.doi.org/10.1051/epjconf/202125203002.

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Abstract (sommario):

Alpha emitting radionuclides with medically relevant half-lives are interesting for treatment of tumors and other diseases because they deposit large amounts of energy close to the location of the radioisotope. Researchers at the Cyclotron Institute at Texas A&M University are developing a program to produce 211At, an alpha emitter with a medically relevant half-life. The properties of 211At make it a great candidate for targeted alpha therapy for cancer due to its short half-life (7.2 h). Astatine-211 has now been produced multiple times and reliability of this process is being improved.