Articoli di riviste sul tema "APP and amyloid fragments"
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Yokota, Masayuki, Takaomi C. Saido, Eiichi Tani, Ikuya Yamaura e Nobutaka Minami. "Cytotoxic Fragment of Amyloid Precursor Protein Accumulates in Hippocampus after Global Forebrain Ischemia". Journal of Cerebral Blood Flow & Metabolism 16, n. 6 (novembre 1996): 1219–23. http://dx.doi.org/10.1097/00004647-199611000-00016.
Chyung, Abraham S. C., Barry D. Greenberg, David G. Cook, Robert W. Doms e Virginia M. Y. Lee. "Novel β-Secretase Cleavage of β-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells". Journal of Cell Biology 138, n. 3 (11 agosto 1997): 671–80. http://dx.doi.org/10.1083/jcb.138.3.671.
Niederst, Emily D., Sol M. Reyna e Lawrence S. B. Goldstein. "Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing". Molecular Biology of the Cell 26, n. 2 (15 gennaio 2015): 205–17. http://dx.doi.org/10.1091/mbc.e14-06-1049.
Lee, Ming-Sum, Shih-Chu Kao, Cynthia A. Lemere, Weiming Xia, Huang-Chun Tseng, Ying Zhou, Rachael Neve, Michael K. Ahlijanian e Li-Huei Tsai. "APP processing is regulated by cytoplasmic phosphorylation". Journal of Cell Biology 163, n. 1 (13 ottobre 2003): 83–95. http://dx.doi.org/10.1083/jcb.200301115.
Feng, Fei, Yuanyuan Li, Nanqu Huang e Yong Luo. "Icaritin, an inhibitor of beta-site amyloid cleaving enzyme-1, inhibits secretion of amyloid precursor protein in APP-PS1-HEK293 cells by impeding the amyloidogenic pathway". PeerJ 7 (10 dicembre 2019): e8219. http://dx.doi.org/10.7717/peerj.8219.
Ghiso, J., A. Rostagno, J. E. Gardella, L. Liem, P. D. Gorevic e B. Frangione. "A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion". Biochemical Journal 288, n. 3 (15 dicembre 1992): 1053–59. http://dx.doi.org/10.1042/bj2881053.
Cook, J. J., K. R. Wildsmith, D. B. Gilberto, M. A. Holahan, G. G. Kinney, P. D. Mathers, M. S. Michener et al. "Acute -Secretase Inhibition of Nonhuman Primate CNS Shifts Amyloid Precursor Protein (APP) Metabolism from Amyloid- Production to Alternative APP Fragments without Amyloid- Rebound". Journal of Neuroscience 30, n. 19 (12 maggio 2010): 6743–50. http://dx.doi.org/10.1523/jneurosci.1381-10.2010.
Yu, Yang, Yang Gao, Bengt Winblad, Lars O. Tjernberg e Sophia Schedin-Weiss. "A Super-Resolved View of the Alzheimer’s Disease-Related Amyloidogenic Pathway in Hippocampal Neurons". Journal of Alzheimer's Disease 83, n. 2 (14 settembre 2021): 833–52. http://dx.doi.org/10.3233/jad-215008.
Stieren, Emily S., Amina El Ayadi, Yao Xiao, Efraín Siller, Megan L. Landsverk, Andres F. Oberhauser, José M. Barral e Darren Boehning. "Ubiquilin-1 Is a Molecular Chaperone for the Amyloid Precursor Protein". Journal of Biological Chemistry 286, n. 41 (18 agosto 2011): 35689–98. http://dx.doi.org/10.1074/jbc.m111.243147.
Ono, Kenji, Mikio Niwa, Hiromi Suzuki, Nahoko Bailey Kobayashi, Tetsuhiko Yoshida e Makoto Sawada. "Signal Sequence-Dependent Orientation of Signal Peptide Fragments to Exosomes". International Journal of Molecular Sciences 23, n. 6 (15 marzo 2022): 3137. http://dx.doi.org/10.3390/ijms23063137.
Xie, Zhongcong, Yuanlin Dong, Uta Maeda, Weiming Xia e Rudolph E. Tanzi. "RNA Interference Silencing of the Adaptor Molecules ShcC and Fe65 Differentially Affect Amyloid Precursor Protein Processing and Aβ Generation". Journal of Biological Chemistry 282, n. 7 (14 dicembre 2006): 4318–25. http://dx.doi.org/10.1074/jbc.m609293200.
Marttinen, Mikael, Catarina B. Ferreira, Kaisa M. A. Paldanius, Mari Takalo, Teemu Natunen, Petra Mäkinen, Luukas Leppänen et al. "Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Aβ". Cells 9, n. 11 (15 novembre 2020): 2482. http://dx.doi.org/10.3390/cells9112482.
Hao, Candy Yan, Michael S. Perkinton, William Wai-Lun Chan, Ho Yin Edwin Chan, Christopher C. J. Miller e Kwok-Fai Lau. "GULP1 is a novel APP-interacting protein that alters APP processing". Biochemical Journal 436, n. 3 (27 maggio 2011): 631–39. http://dx.doi.org/10.1042/bj20110145.
Kuentzel, S. L., S. M. Ali, R. A. Altman, B. D. Greenberg e T. J. Raub. "The Alzheimer β-amyloid protein precursor/protease nexin-II is cleaved by secretase in a trans-Golgi secretory compartment in human neuroglioma cells". Biochemical Journal 295, n. 2 (15 ottobre 1993): 367–78. http://dx.doi.org/10.1042/bj2950367.
Ono, Kenji, Mikio Niwa, Hiromi Suzuki, Nahoko Bailey Kobayashi, Tetsuhiko Yoshida e Makoto Sawada. "Calmodulin as a Key Regulator of Exosomal Signal Peptides". Cells 12, n. 1 (30 dicembre 2022): 158. http://dx.doi.org/10.3390/cells12010158.
Annaert, Wim G., Lyne Levesque, Kathleen Craessaerts, Inge Dierinck, Greet Snellings, David Westaway, Peter St George-Hyslop, Barbara Cordell, Paul Fraser e Bart De Strooper. "Presenilin 1 Controls γ-Secretase Processing of Amyloid Precursor Protein in Pre-Golgi Compartments of Hippocampal Neurons". Journal of Cell Biology 147, n. 2 (18 ottobre 1999): 277–94. http://dx.doi.org/10.1083/jcb.147.2.277.
Cater, Michael A., Kelly T. McInnes, Qiao-Xin Li, Irene Volitakis, Sharon La Fontaine, Julian F. B. Mercer e Ashley I. Bush. "Intracellular copper deficiency increases amyloid-β secretion by diverse mechanisms". Biochemical Journal 412, n. 1 (25 aprile 2008): 141–52. http://dx.doi.org/10.1042/bj20080103.
Maarouf, Chera L., Tyler A. Kokjohn, Charisse M. Whiteside, MiMi P. Macias, Walter M. Kalback, Marwan N. Sabbagh, Thomas G. Beach, Robert Vassar e Alex E. Roher. "Molecular Differences and Similarities between Alzheimer's Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis". Biochemistry Insights 6 (gennaio 2013): BCI.S13025. http://dx.doi.org/10.4137/bci.s13025.
Pang, Keliang, Richeng Jiang, Wei Zhang, Zhengyi Yang, Lin-Lin Li, Makoto Shimozawa, Simone Tambaro et al. "An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments". Cell Research 32, n. 2 (17 novembre 2021): 157–75. http://dx.doi.org/10.1038/s41422-021-00582-x.
Hajdú, István, Barbara M. Végh, András Szilágyi e Péter Závodszky. "Beta-Secretase 1 Recruits Amyloid-Beta Precursor Protein to ROCK2 Kinase, Resulting in Erroneous Phosphorylation and Beta-Amyloid Plaque Formation". International Journal of Molecular Sciences 24, n. 13 (21 giugno 2023): 10416. http://dx.doi.org/10.3390/ijms241310416.
Crino, Peter B., Barry Greenberg, John A. Martin, Virginia M. Y. Lee, William D. Hill e John Q. Trojanowski. "β-Amyloid Peptide and Amyloid Precursor Proteins in Olfactory Mucosa of Patients with Alzheimer's Disease, Parkinson's Disease, and down Syndrome". Annals of Otology, Rhinology & Laryngology 104, n. 8 (agosto 1995): 655–61. http://dx.doi.org/10.1177/000348949510400812.
Ghiso, J., T. Wisniewski, R. Vidal, A. Rostagno e B. Frangione. "Epitope map of two polyclonal antibodies that recognize amyloid lesions in patients with Alzheimer's disease". Biochemical Journal 282, n. 2 (1 marzo 1992): 517–22. http://dx.doi.org/10.1042/bj2820517.
van den Hurk, Wilhelmina H., Heidi J. J. Willems, Marjon Bloemen e Gerard J. M. Martens. "Novel Frameshift Mutations near Short Simple Repeats". Journal of Biological Chemistry 276, n. 15 (3 gennaio 2001): 11496–98. http://dx.doi.org/10.1074/jbc.m011040200.
Yao, Yinan, Seong Su Kang, Yiyuan Xia, Zhi-Hao Wang, Xia Liu, Thorsten Muller, Yi E. Sun e Keqiang Ye. "A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer’s disease pathologies". Brain 144, n. 6 (20 aprile 2021): 1833–52. http://dx.doi.org/10.1093/brain/awab062.
Xie, Zhongcong, Yuanlin Dong, Uta Maeda, Paul Alfille, Deborah J. Culley, Gregory Crosby e Rudolph E. Tanzi. "The Common Inhalation Anesthetic Isoflurane Induces Apoptosis and Increases Amyloid β Protein Levels". Anesthesiology 104, n. 5 (1 maggio 2006): 988–94. http://dx.doi.org/10.1097/00000542-200605000-00015.
Huttunen, Henri J., Suzanne Y. Guénette, Camilla Peach, Christopher Greco, Weiming Xia, Doo Yeon Kim, Cory Barren, Rudolph E. Tanzi e Dora M. Kovacs. "HtrA2 Regulates β-Amyloid Precursor Protein (APP) Metabolism through Endoplasmic Reticulum-associated Degradation". Journal of Biological Chemistry 282, n. 38 (6 agosto 2007): 28285–95. http://dx.doi.org/10.1074/jbc.m702951200.
Grangeon, Lou, Kévin Cassinari, Stéphane Rousseau, Bernard Croisile, Maïté Formaglio, Olivier Moreaud, Jean Boutonnat et al. "Early-Onset Cerebral Amyloid Angiopathy and Alzheimer Disease Related to an APP Locus Triplication". Neurology Genetics 7, n. 5 (8 settembre 2021): e609. http://dx.doi.org/10.1212/nxg.0000000000000609.
Jowsey, Paul A., e Peter G. Blain. "Fe65 Ser228 is phosphorylated by ATM/ATR and inhibits Fe65–APP-mediated gene transcription". Biochemical Journal 465, n. 3 (22 gennaio 2015): 413–21. http://dx.doi.org/10.1042/bj20140656.
Nguyen, Khue Vu. "The human β-amyloid precursor protein: biomolecular and epigenetic aspects". Biomolecular Concepts 6, n. 1 (1 marzo 2015): 11–32. http://dx.doi.org/10.1515/bmc-2014-0041.
Wang, Bo-Jeng, Guor Mour Her, Ming-Kuan Hu, Yun-Wen Chen, Ying-Tsen Tung, Pei-Yi Wu, Wen-Ming Hsu et al. "ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer’s disease". Proceedings of the National Academy of Sciences 114, n. 15 (28 marzo 2017): E3129—E3138. http://dx.doi.org/10.1073/pnas.1618804114.
Vaillant-Beuchot, Loan, Arnaud Mary, Raphaëlle Pardossi-Piquard, Alexandre Bourgeois, Inger Lauritzen, Fanny Eysert, Paula Fernanda Kinoshita et al. "Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains". Acta Neuropathologica 141, n. 1 (20 ottobre 2020): 39–65. http://dx.doi.org/10.1007/s00401-020-02234-7.
Dorval, Véronique, Matthew J. Mazzella, Paul M. Mathews, Ronald T. Hay e Paul E. Fraser. "Modulation of Aβ generation by small ubiquitin-like modifiers does not require conjugation to target proteins". Biochemical Journal 404, n. 2 (14 maggio 2007): 309–16. http://dx.doi.org/10.1042/bj20061451.
Bussiere, Oulès, Mary, Vaillant-Beuchot, Martin, Manaa, Vallée et al. "Upregulation of the Sarco-Endoplasmic Reticulum Calcium ATPase 1 Truncated Isoform Plays a Pathogenic Role in Alzheimer’s Disease". Cells 8, n. 12 (28 novembre 2019): 1539. http://dx.doi.org/10.3390/cells8121539.
Augutis, Kristin, Markus Axelsson, Erik Portelius, Gunnar Brinkmalm, Ulf Andreasson, Mikael K. Gustavsson, Clas Malmeström et al. "Cerebrospinal fluid biomarkers of β-amyloid metabolism in multiple sclerosis". Multiple Sclerosis Journal 19, n. 5 (15 ottobre 2012): 543–52. http://dx.doi.org/10.1177/1352458512460603.
K. Lakshmana, Madepalli, Subhojit Roy, Kaihong Mi e David E. Kang. "Amyloidogenic Processing of APP in Lipid Rafts". Open Biology Journal 3, n. 1 (19 marzo 2010): 21–31. http://dx.doi.org/10.2174/18741967010030100021.
Tan, Jing Zhi A., e Paul A. Gleeson. "The trans-Golgi network is a major site for α-secretase processing of amyloid precursor protein in primary neurons". Journal of Biological Chemistry 294, n. 5 (13 dicembre 2018): 1618–31. http://dx.doi.org/10.1074/jbc.ra118.005222.
Szögi, Titanilla, Ildikó Schuster, Emőke Borbély, Andrea Gyebrovszki, Zsolt Bozsó, János Gera, Róbert Rajkó, Miklós Sántha, Botond Penke e Lívia Fülöp. "Effects of the Pentapeptide P33 on Memory and Synaptic Plasticity in APP/PS1 Transgenic Mice: A Novel Mechanism Presenting the Protein Fe65 as a Target". International Journal of Molecular Sciences 20, n. 12 (22 giugno 2019): 3050. http://dx.doi.org/10.3390/ijms20123050.
Kuznetsov, I. A., e A. V. Kuznetsov. "Simulating the effect of formation of amyloid plaques on aggregation of tau protein". Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences 474, n. 2220 (dicembre 2018): 20180511. http://dx.doi.org/10.1098/rspa.2018.0511.
Masi, Mirco, Fabrizio Biundo, André Fiou, Marco Racchi, Alessia Pascale e Erica Buoso. "The Labyrinthine Landscape of APP Processing: State of the Art and Possible Novel Soluble APP-Related Molecular Players in Traumatic Brain Injury and Neurodegeneration". International Journal of Molecular Sciences 24, n. 7 (2 aprile 2023): 6639. http://dx.doi.org/10.3390/ijms24076639.
Netzer, William J., Karima Bettayeb, Subhash C. Sinha, Marc Flajolet, Paul Greengard e Victor Bustos. "Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage". Proceedings of the National Academy of Sciences 114, n. 6 (23 gennaio 2017): 1389–94. http://dx.doi.org/10.1073/pnas.1620963114.
Hoe, Hyang-Sook, David Wessner, Uwe Beffert, Amanda G. Becker, Yasuji Matsuoka e G. William Rebeck. "F-Spondin Interaction with the Apolipoprotein E Receptor ApoEr2 Affects Processing of Amyloid Precursor Protein". Molecular and Cellular Biology 25, n. 21 (1 novembre 2005): 9259–68. http://dx.doi.org/10.1128/mcb.25.21.9259-9268.2005.
Schmitt, T. L. "Thyroid epithelial cells produce large amounts of the Alzheimer beta- amyloid precursor protein (APP) and generate potentially amyloidogenic APP fragments". Journal of Clinical Endocrinology & Metabolism 80, n. 12 (1 dicembre 1995): 3513–19. http://dx.doi.org/10.1210/jc.80.12.3513.
Schmitt, T. L., E. Steiner, P. Klingler, H. Lassmann e B. Grubeck-Loebenstein. "Thyroid epithelial cells produce large amounts of the Alzheimer beta-amyloid precursor protein (APP) and generate potentially amyloidogenic APP fragments." Journal of Clinical Endocrinology & Metabolism 80, n. 12 (dicembre 1995): 3513–19. http://dx.doi.org/10.1210/jcem.80.12.8530592.
Mori, Takashi, Naoki Koyama, Tatsuya Segawa, Masahiro Maeda, Nobuhiro Maruyama, Noriaki Kinoshita, Huayan Hou, Jun Tan e Terrence Town. "Methylene Blue Modulates β-Secretase, Reverses Cerebral Amyloidosis, and Improves Cognition in Transgenic Mice". Journal of Biological Chemistry 289, n. 44 (25 agosto 2014): 30303–17. http://dx.doi.org/10.1074/jbc.m114.568212.
Hefter, Dimitri, Susann Ludewig, Andreas Draguhn e Martin Korte. "Amyloid, APP, and Electrical Activity of the Brain". Neuroscientist 26, n. 3 (29 novembre 2019): 231–51. http://dx.doi.org/10.1177/1073858419882619.
BORCHARDT, Thilo, James CAMAKARIS, Roberto CAPPAI, Colin L. MASTERS, Konrad BEYREUTHER e Gerd MULTHAUP. "Copper inhibits β-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion". Biochemical Journal 344, n. 2 (24 novembre 1999): 461–67. http://dx.doi.org/10.1042/bj3440461.
Barron, A. M., M. Cake, G. Verdile e R. N. Martins. "Ovariectomy and 17β-Estradiol Replacement Do Not Alter β-Amyloid Levels in Sheep Brain". Endocrinology 150, n. 7 (12 marzo 2009): 3228–36. http://dx.doi.org/10.1210/en.2008-1252.
Paschou, Maria, Danai Liaropoulou, Vasileia Kalaitzaki, Spiros Efthimiopoulos e Panagiota Papazafiri. "Knockdown of Amyloid Precursor Protein Increases Ion Channel Expression and Alters Ca2+ Signaling Pathways". International Journal of Molecular Sciences 24, n. 3 (24 gennaio 2023): 2302. http://dx.doi.org/10.3390/ijms24032302.
Li, Wei, Xiang Gao, Junle Ren, Ting An e Yan Liu. "High Expression and Purification of Amino-Terminal Fragment of Human Amyloid Precursor Protein inPichia pastorisand Partial Analysis of Its Properties". BioMed Research International 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/836429.
Bergman, Anna, Hanna Laudon, Bengt Winblad, Johan Lundkvist e Jan Näslund. "The Extreme C Terminus of Presenilin 1 Is Essential for γ-Secretase Complex Assembly and Activity". Journal of Biological Chemistry 279, n. 44 (20 agosto 2004): 45564–72. http://dx.doi.org/10.1074/jbc.m407717200.