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Letteratura scientifica selezionata sul tema "Antitumoral properties"

Autore: Grafiati

Pubblicato: 19 ottobre 2024

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Articoli di riviste sul tema "Antitumoral properties"

Fabiani, Roberto. "Antitumoral Properties of Natural Products". Molecules 25, n. 3 (3 febbraio 2020): 650. http://dx.doi.org/10.3390/molecules25030650.

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McLachlan, J. A., C. D. Serkin, K. M. Morrey e O. Bakouche. "Antitumoral properties of aged human monocytes." Journal of Immunology 154, n. 2 (15 gennaio 1995): 832–43. http://dx.doi.org/10.4049/jimmunol.154.2.832.

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Abstract It is known that older people are more sensitive to cancer and infectious agents and need more time to recover from such disorders. Can this difference in sensitivity to cancer and infections between elderly and younger people be a result of a difference in their immune systems and, more specifically, in the way monocytes react to infectious agents and cancer cells? To determine what happens after cells have aged, human monocytes were purified from young donors (approximately 25 years of age) and from older donors (65 years of age or older) and tested for their ability to respond to the polyclonal activator LPS. Our results showed that monocytes from aged donors (aged monocytes), when compared with monocytes from younger donors (young monocytes) did lose part of their cytotoxicity against tumor cells (A375 human melanoma cells and L929 murine fibroblast cells). In addition, aged monocytes displayed a sharp decrease in IL-1 secretion, but did display the intracellular 31 kDa IL-1 precursor. Moreover, aged monocytes displayed a decrease in the production of reactive oxygen intermediates such as NO2 and H2O2. Finally, aged monocytes stimulated by LPS displayed an increase in intracellular cyclic AMP and have lost their protein kinase C translocation from the cytosol to the plasma membranes. These results suggest that age affects the immunologic and antitumoral properties of human monocytes.

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Braca, A. "Insight on antitumoral properties of plant diterpenes". Planta Medica 81, S 01 (14 dicembre 2016): S1—S381. http://dx.doi.org/10.1055/s-0036-1596105.

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Pandiella-Alonso, Atanasio, Elena Díaz-Rodríguez e Eduardo Sanz. "Antitumoral Properties of the Nutritional Supplement Ocoxin Oral Solution: A Comprehensive Review". Nutrients 12, n. 9 (31 agosto 2020): 2661. http://dx.doi.org/10.3390/nu12092661.

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Ocoxin Oral Solution (OOS) is a nutritional supplement whose formulation includes several plant extracts and natural products with demonstrated antitumoral properties. This review summarizes the antitumoral action of the different constituents of OOS. The action of this formulation on different preclinical models as well as clinical trials is reviewed, paying special attention to the mechanism of action and quality of life improvement properties of this nutritional supplement. Molecularly, its mode of action includes a double edge role on tumor biology, that involves a slowdown in cell proliferation accompanied by cell death induction. Given the safety and good tolerability of OOS, and its potentiation of the antitumoral effect of other standard of care drugs, OOS may be used in the oncology clinic in combination with conventional therapies.

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Lungu, Claudiu N., Bogdan Ionel Bratanovici, Maria Mirabela Grigore, Vasilichia Antoci e Ionel I. Mangalagiu. "Hybrid Imidazole-Pyridine Derivatives: An Approach to Novel Anticancer DNA Intercalators". Current Medicinal Chemistry 27, n. 1 (18 febbraio 2020): 154–69. http://dx.doi.org/10.2174/0929867326666181220094229.

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Lack of specificity and subsequent therapeutic effectiveness of antimicrobial and antitumoral drugs is a common difficulty in therapy. The aim of this study is to investigate, both by experimental and computational methods, the antitumoral and antimicrobial properties of a series of synthesized imidazole-pyridine derivatives. Interaction with three targets was discussed: Dickerson-Drew dodecamer (PDB id 2ADU), G-quadruplex DNA string (PDB id 2F8U) and DNA strain in complex with dioxygenase (PDB id 3S5A). Docking energies were computed and represented graphically. On them, a QSAR model was developed in order to further investigate the structure-activity relationship. Results showed that synthesized compounds have antitumoral and antimicrobial properties. Computational results agreed with the experimental data.

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Iacopetta, Domenico, Jessica Ceramella, Alessia Catalano, Carmela Saturnino, Maria Grazia Bonomo, Carlo Franchini e Maria Stefania Sinicropi. "Schiff Bases: Interesting Scaffolds with Promising Antitumoral Properties". Applied Sciences 11, n. 4 (20 febbraio 2021): 1877. http://dx.doi.org/10.3390/app11041877.

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Schiff bases, named after Hugo Schiff, are highly reactive organic compounds broadly used as pigments and dyes, catalysts, intermediates in organic synthesis, and polymer stabilizers. Lots of Schiff bases are described in the literature for various biological activities, including antimalarial, antibacterial, antifungal, anti-inflammatory, and antiviral. Schiff bases are also known for their ability to form complexes with several metals. Very often, complexes of Schiff bases with metals and Schiff bases alone have demonstrated interesting antitumor activity. Given the innumerable vastness of data regarding antitumor activity of all these compounds, we focused our attention on mono- and bis-Schiff bases alone as antitumor agents. We will highlight the most significant examples of compounds belonging to this class reported in the literature.

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Perez-Tomas, R., e M. Vinas. "New Insights on the Antitumoral Properties of Prodiginines". Current Medicinal Chemistry 17, n. 21 (1 luglio 2010): 2222–31. http://dx.doi.org/10.2174/092986710791331103.

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Nava-Villalba, Mario, e Carmen Aceves. "6-Iodolactone, key mediator of antitumoral properties of iodine". Prostaglandins & Other Lipid Mediators 112 (agosto 2014): 27–33. http://dx.doi.org/10.1016/j.prostaglandins.2014.07.001.

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Adam, Gigi, Florina Daniela Cojocaru, Liliana Verestiuc, Oana Cioanca, Ingrid-Andrada Vasilache, Ana-Maria Adam, Cornelia Mircea et al. "Assessing the Antioxidant Properties, In Vitro Cytotoxicity and Antitumoral Effects of Polyphenol-Rich Perilla leaves Extracts". Antioxidants 13, n. 1 (29 dicembre 2023): 58. http://dx.doi.org/10.3390/antiox13010058.

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(1) Background: This study aimed to outline the antioxidant, antitumoral, and cytotoxic proprieties of various types of Perilla frutescens extracts obtained from the leaves of the species. (2) Methods: We determined total polyphenols, flavonoids and anthocyanins contents, as well as the in vitro antioxidant, antitumoral, and cytotoxic actions in three types of ethanolic extracts (E1, E2, E3) and in three types of acetone: ethanol extracts (A1, A2, A3) of Perilla frutescens according to standardized procedures. (3) Results: We found that Perilla frutescens ethanolic extracts had the highest total phenol and anthocyanins concentrations. The flavonoids concentration was not statistically different between the extracts. The iron chelating capacity, hydroxyl radical scavenging capacity, superoxide anion radical scavenging capacity, and lipoxygenase inhibition capacity showed a significant increase with higher concentrations of Perilla frutescens extracts, particularly the ethanolic extracts. Perillyl alcohol had greater cytotoxic capacity in the MG-63 cell line and E1 extract showed similar significant cytotoxic effects in the A431 cell line. (4) Conclusions: Both ethanolic and acetone–ethanol extracts from Perilla frutescens exhibited important antioxidant and antitumoral actions in vitro, which proportionally increased with concentration. The cytotoxic threshold determined in this study for various types of extracts could help determine the best dosage with the maximum antioxidant and antitumoral potential. Our results could serve as a basis for further studies that will investigate the cytotoxic effects of Perilla frutescens variants on various types of cancer cell lines.

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Esteruelas, Gerard, Eliana B. Souto, Marta Espina, María Luisa García, Marta Świtalska, Joanna Wietrzyk, Anna Gliszczyńska e Elena Sánchez-López. "Diclofenac Loaded Biodegradable Nanoparticles as Antitumoral and Antiangiogenic Therapy". Pharmaceutics 15, n. 1 (28 dicembre 2022): 102. http://dx.doi.org/10.3390/pharmaceutics15010102.

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Cancer is identified as one of the main causes of death worldwide, and an effective treatment that can reduce/eliminate serious adverse effects is still an unmet medical need. Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), has demonstrated promising antitumoral properties. However, the prolonged use of this NSAID poses several adverse effects. These can be overcome by the use of suitable delivery systems that are able to provide a controlled delivery of the payload. In this study, Diclofenac was incorporated into biodegradable polymeric nanoparticles based on PLGA and the formulation was optimized using a factorial design approach. A monodisperse nanoparticle population was obtained with a mean size of ca. 150 nm and negative surface charge. The release profile of diclofenac from the optimal formulation followed a prolonged release kinetics. Diclofenac nanoparticles demonstrated antitumoral and antiangiogenic properties without causing cytotoxicity to non-tumoral cells, and can be pointed out as a safe, promising and innovative nanoparticle-based formulation with potential antitumoral effects.

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Più fonti

Tesi sul tema "Antitumoral properties"

Panosa, Roqueta Clara. "Antitumoral properties of epidermal growth factor derivatives". Doctoral thesis, Universitat de Girona, 2015. http://hdl.handle.net/10803/369050.

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The members of the epidermal growth factor (EGF) / ErbB family are prime targets for cancer therapy. However, the therapeutic efficiency of the existing anti-ErbB agents is limited. Thus, identifying new molecules that inactivate the ErbB receptors through novel strategies is an important goal on cancer research. In this thesis work we have developed a shorter form of human EGF (EGFt) with a truncated C-terminal as a novel EGFR inhibitor. EGFt was designed based on the superimposition of the three-dimensional structures of EGF and the Potato Carboxypeptidase Inhibitor (PCI), an EGFR blocker previously described by our group. The peptide was produced in E. coli with a high yield of the correctly folded peptide. EGFt induced poor EGFR homodimerization and phosphorylation. Interestingly, EGFt promoted EGFR internalization and translocation to the cell nucleus although it did not stimulate the cell growth. In addition, EGFt competed with EGFR native ligands, inhibiting the proliferation of cancer cells. The lack of EGFR-mediated growth-stimulatory activity prompted us to evaluate EGFt for targeted delivery of 111In, an Auger electron emitter, into EGFR-positive cancer cells. An 111In-DTPA-EGFt radioconjugate was developed and its properties were analyzed and compared to those of 111In-DTPA-hEGF. First we determined that 111In-DTPA-EGFt displays high specificity and affinity for EGFR. However, the cellular uptake of 111In-DTPA-EGFt resulted to be lower than that of 111In-DTPA-hEGF. Once internalized, 111In-DTPA-EGFt showed a high efficiency to accumulate into the cell nucleus, where the radioactivity emitted by 111In may damage the DNA. In accordance, 111In-DTPA-EGFt showed to be cytotoxic in vitro against breast cancer cells, although its cytotoxicity was lower compared to 111In-DTPA-hEGF. In vivo studies revealed a longer half-life in blood for 111In-DTPA-EGFt than for 111In-DTPA-hEGF and higher uptake in the kidney, with minor accumulation in other normal tissues. 111In-DTPA-EGFt accumulated in MDA-MB-468 tumors where, interestingly, 111In-DTPA-EGFt was detected in a great proportion in the cell nucleus. All the data obtained from this work indicate that EGFt may be a potential EGFR blocker for cancer therapy and also an attractive ligand for delivery of cytotoxic agents into the nucleus of EGFR-positive cancer cells.
Els receptors i lligands de la família del factor de creixement epidèrmic (EGF)/ErbB són dianes molt importants en el desenvolupament de teràpies contra el càncer. No obstant, l’eficàcia terapèutica dels fàrmacs dirigits a atacar aquesta via i que són utilitzats actualment en clínica és limitada. Per aquest motiu la recerca de noves molècules que inactivin els receptors d’aquesta família mitjançant noves estratègies és avui dia una de les vies més explorades. En aquesta tesi s’ha desenvolupat un pèptid idèntic al factor de creixement epidèrmic EGF que li manca la seva part C-terminal (EGFt) com a nou inhibidor de EGFR. El disseny d’aquest pèptid truncat s’ha basat en la superposició tridimensional de l’estructura de l’EGF i de l’inhibidor de la carboxipeptidasa de patata (PCI), un bloquejador de la via de l’EGFR descrit prèviament pel nostre grup. El pèptid ha estat produït en E.coli i s’ha aconseguit obtenir un alt rendiment de la proteïna i amb la seva conformació estructural correcta. Hem observat que l’EGFt in vitro té una capacitat molt menor per induir dímers del receptor i també la seva fosforilació si la comparem amb l’activitat que té l’hEGF natiu. Per altra banda, l’EGFt promou la internalització del receptor i la seva translocació al nucli cel·lular tal i com ho fa l’hEGF, tot i que no estimula el creixement cel·lular. A més, l’EGFt competeix amb els lligands natius de la família i inhibeix la proliferació cel·lular. La manca d’activitat estimuladora del creixement cel·lular d’aquest pèptid quan s’uneix a l’EGFR ens va portar a provar la utilització de l’EGFt com a vehicle de toxines dirigit a cèl·lules tumorals que sobreexpresessin EGFR. Concretament, es va produir un radioconjugat de EGFt amb l’isòtop radioactiu emissor d’electrons Auger Indi-111. Les propietats d’aquest radioconjugat es van analitzar i es van comparar amb el radioconjugat produït amb hEGF natiu. En primer lloc es va determinar que 111In-DTPA-EGFt té una alta especificitat i afinitat per EGFR. No obstant, la captació cel·lular de 111In-DTPA-EGFt va resultar ser menor que la de 111In-DTPA-hEGF. Un cop internalitzat, 111In-DTPA-EGFt va mostrar una alta eficiència per acumular-se en el nucli de la cèl·lula, on la radioactivitat emesa per 111In danya l'ADN. 111In-DTPA-EGFt va mostrar ser citotòxic in vitro contra cèl·lules de càncer de mama, encara que la seva citotoxicitat va ser menor en comparació amb 111In-DTPA-hEGF. Els estudis in vivo van revelar una vida mitjana més llarga en sang per 111In-DTPA-EGFt que per 111In-DTPA-hEGF, una major captació en el ronyó i una menor acumulació en altres teixits normals. 111In-DTPA-EGFt es va detectar en els tumors de cèl·lules MDA-MB-468 on el radiocompost es va acumular preferentment en el nucli de la cèl·lula. Les dades recollides en aquest treball indiquen que l’EGFt pot tenir un gran potencial com a bloquejador en teràpia pel càncer i a més pot ser un bon lligand per utilitzar com a vehicle d’agents citotòxics dirigits al nucli de cèl·lules tumorals positives en EGFR.

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Tonello, Andrea <1988&gt. "Synthesis and Engineering of PLGA-based Nanoparticles with antitumoral Properties". Master's Degree Thesis, Università Ca' Foscari Venezia, 2014. http://hdl.handle.net/10579/5394.

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Nano-based delivery systems have attracted a great deal of attention in the past two decades as a strategy to overcome the low therapeutic index of conventional anticancer drugs. Nanoparticles enable the delivery of a great variety of drugs including analgesics, anti-Alzheimer's drugs, cardiovascular drugs, and several macromolecules into the brain after intravenous injection of animals. The mechanism of nanoparticle-mediated drug transport across the blood-brain barrier appears to be receptor-mediated endocytosis followed by drug release within the endothelial cells. Modification of the nanoparticle surface with covalently attached targeting ligands lead to the adsorption of specific proteins after injection is necessary for this receptor-mediated uptake. A very critical and important requirement for nanoparticulate brain delivery is that the employed nanoparticles are biocompatible and, moreover, rapidly biodegradable, i.e. over a time frame of a few days. In addition to enabling drug delivery to the brain, PLGA-based nanoparticles, with bisabolol inside, may importantly reduce the drug's toxicity. Because of the possibility to treat severe central nervous system diseases such as brain tumors and to even transport proteins and other macromolecules across the blood–brain barrier, this technology holds great promise for a non-invasive therapy of these diseases.

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Zou, Yu. "Dendrimères et dendrons phosphorés : synthèse, propriétés et applications en nanomédecine". Electronic Thesis or Diss., Université de Toulouse (2023-....), 2024. http://www.theses.fr/2024TLSES093.

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L'objectif de ce travail de thèse a été de préparer de nouveaux dendrimères ou dendrons phosphorés, qu'ils soient neutres, cationiques ou anioniques, dans le but d'élargir le panel des applications dans le domaine de la nanomédecine en tant que molécules actives par elles-mêmes ou en association avec certains médicaments. Au chapitre 1, la synthèse d'un nouveau dendrimère phosphoré polycationique comportant en surface 5 groupements pyrrolidinium et une amine protonnée a été menée à bien. Ce dendrimère associé au microRNA-30d permet d'obtenir des polyplexes qui sont transférés dans les cellules cancéreuses. Il a également un bon effet thérapeutique sur les cellules cancéreuses du sein. Au Chapitre 2, l'objectif était de développer un système de délivrance de médicaments capables de pénétrer les lésions cérébrales pour proposer un traitement de la maladie de Parkinson. Pour cela, il a été mis au point la formation d'un nanocomplexe formé d'un dendrimère phosphoré porteur de groupements hydroxyl en surface, combiné avec la fibronectine, qui règle la prolifération et la différenciation et la motilité cellulaire. Sur un modèle murin de la maladie de Parkinson, il a été mis en évidence une pénétration efficace au niveau de la BBB (blood brain barrier) de l'assemblage dendrimère phosphoré AK-123 et fibronectine exerçant une activité anti-inflammatoire et antioxydante permettant de soulager efficacement les symptômes observés et démontrant le grand potentiel pour un traitement clinique de la maladie de Parkinson mais aussi ouvrant un espoir de viser d'autres maladies neurodégénératives. Au Chapitre 3, les résultats obtenus dans le domaine de la maladie de Parkinson lors de l'action conjuguée d'un dendrimère phosphoré de génération 2 comportant 48 groupements hydroxy en surface et de la fibronectine nous ont incités à diversifier la nature et la structure de ces dendrimères afin d'avoir des premières indications de leur activité en général et d'aborder éventuellement une étude SAR (relation structure activité). Pour cela nous avons pu préparer tout un ensemble de nouveaux dendrimères phosphorés neutres de générations 1 et 2, caractérisés par des structures internes différentes de celles des dendrimères utilisés dans le chapitre précèdent, et de longues chaines en surface comportant également des groupements hydroxyle. Ces dendrimères ont l'avantage de posséder des groupements amines protonées permettant une solubilité en milieu aqueux. Nous avons pu également préparer des dendrons phosphorés neutres et chargés. Des résultats préliminaires concernant leurs propriétés ont pu être mis en évidence. Au Chapitre 4, Le but de notre étude a porté tout d'abord sur la synthèse de dendrimères phosphorés anioniques originaux et à l'utilisation d'un de ces dendrimères en l'occurrence le dendrimère AK 137 qui présente une activité anti-inflammatoire optimale et une grande aptitude pour la délivrance de protéines. Des nanocomplexes stables formés par ce dendrimère et diverses protéines en solution aqueuse (bovine serum albumin (BSA), ribonucleaseA (RNaA), ovalbumine (OVA) et fibronectine (FN) ont été obtenus. Nous avons pu démontrer que l'association AK-137@FN NCs bloque l'activation de certaines voies de signalisation (NF-kB et P13K/Akt), induit la polarisation de macrophages vers des phénotypes M2, inhibe la sécrétion de cytokines pro-inflammatoires (TNF-alpha, IL-1beta et IL6) et augmente les propriétés antioxydante de FN in vitro. Les effets thérapeutiques de l'association AK-137@FN ont été démontrés sur des modèles de souris ALI (acute lung injury) et AGA (acute gout arthritis) sans observation de toxicité systémique
The objective of this thesis work was to prepare new phosphorous dendrimers or phosphorous dendrons, either neutral, cationic or anionic, with the aim of broadening the range of applications in the field of nanomedicine as molecules active by per se. or in combination with certain medications. In Chapter 1, the synthesis of a new polycationic phosphorus dendrimer comprising 5 pyrrolidinium groups on the surface and a protonated amine was successfully completed. This dendrimer associated with microRNA-30d makes it possible to obtain polyplexes which are transferred into cancer cells in an optimal N/P ratio of 10. These polyplexes are cytocompatible and transfer miR-30d to suppress glycolysis associated with SLC2A1. The inhibition of the migration and invasion of murine cancer cells in vitro and in vivo were thus demonstrated. This dendrimer can be considered as an important component for therapy based on the use of miR-30d. In Chapter 2, we develop a drug delivery system capable of penetrating BBB (blood brain barrier) to provide treatment for degenerative disorders. For this, the formation of a nanocomplex was developed consisting of a phosphorus dendrimer carrying hydroxyl groups on the surface, combined with fibronectin, which regulates proliferation and differentiation and cell motility. In a mouse model of Parkinson's disease, effective penetration at the level of the BBB of the phosphorous dendrimer assembly AK-123 and fibronectin was demonstrated, exerting an anti-inflammatory and antioxidant activity allowing to decrease effectively the symptoms observed and demonstrating the great potential for clinical treatment of Parkinson's disease but also hold great promise to be used to tackle other neurodegenerative disorders. In Chapter 3, the results obtained in the field of Parkinson's disease during the combined action of a generation 2 phosphorous dendrimer comprising 48 hydroxyl groups on the surface and fibronectin have encouraged us to diversify the nature and structure of these dendrimers in order to have first indications of their activity in general and to possibly approach a SAR (structure activity relationship) study. According to these, we prepared a whole set of new neutral phosphorus dendrimers of generations 1 and 2, characterized by internal structures different from those of the dendrimers used in the previous chapter, incorporating long chains on the surface and also comprising hydroxyl groups. These dendrimers have the advantage of having protonated amine groups allowing solubility in an aqueous medium. We were also able to prepare neutral and charged phosphorous dendrons. Preliminary results concerning their properties have been demonstrated. In Chapter 4, the aim of this study was focused on the synthesis of original anionic phosphorus dendrimers and the application of these dendrimers, and particularly of the dendrimer AK 137 which presents optimal anti-inflammatory activity and great efficiency for the delivery of proteins. We demonstrate that the AK-137@FN NCs association blocks the activation of certain signalling pathways (NF-kB and P13K/Akt), induces the polarization of macrophages towards M2 phenotypes, inhibits the secretion of pro-cytokines. (TNF-alpha, IL-1beta and IL6) and increases the antioxidant properties of FN in vitro. The therapeutic effects of the AK-137@FN combination have been demonstrated in ALI (acute lung injury) and AGA (acute gout arthritis) mouse models without observation of systemic toxicity

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Salvador, Cátia Sofia Clemente. "Caracterização de cogumelos silvestres da espécie Amanita ponderosa: produção de metabolitos com atividade biológica". Doctoral thesis, Universidade de Évora, 2014. http://hdl.handle.net/10174/13391.

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Amanita ponderosa é uma espécie de cogumelos silvestres, comestível, característica de alguns microclimas mediterrânicos, existente na Península Ibérica. Neste estudo, avaliaram-se as propriedades biológicas e toxicológicas destes cogumelos e culturas, com vista a valorizar o seu potencial biotecnológico. Desenvolveu-se também uma metodologia de monitorização, utilizando técnicas de microanálise e imunológicas para screening e análise da especificidade de produção dos compostos bioativos. Os corpos de frutificação apresentaram um relevante conteúdo mineral e um perfil molecular correlacionável com o local de colheita. Tanto os cogumelos como as culturas e seus extratos revelaram baixa toxicidade, in vitro e in vivo, apresentaram propriedades antioxidantes, capacidade hepatoprotetora e efeito antiproliferativo em células MDA-MB-231. Estes resultados sugerem que A. ponderosa e/ou os seus extratos podem constituir uma importante fonte de compostos bioativos, com potencial valor nutracêutico e medicinal, podendo ser utilizados como suplementos alimentares, coadjuvantes no tratamento de doenças hepáticas e/ou tumorais; Characterisation of Amanita ponderosa wild mushrooms: production of metabolites with biological activity Abstract: Amanita ponderosa is a species of wild edible mushrooms that grows in some Mediterranean microclimates in the Iberian Peninsula. In this study, we evaluated the biological and toxicological properties of these mushrooms and cultures, in order to enhance their biotechnological potential. A monitoring methodology was also developed using microanalysis and immunological techniques, for screening and specificity evaluation of bioactive compounds production. The fruiting bodies presented a relevant mineral content and a characteristic molecular profile correlated with the geographical location. Either mushrooms or cultures and extracts have shown low toxicity in vitro and in vivo, and presented antioxidant properties, hepatoprotective effect and MDA-MB-231 antiproliferative activity. These results suggest that A. ponderosa and their extracts may constitute an important source of bioactive compounds with antioxidant benefits, nutraceutical potential and medicinal value, that can be used as dietetic supplements and as co-adjuvant of liver and cancer disease treatments.

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Brink, Susanna. "Structure-activity relationships of titanocene complexes with antitumor properties". Pretoria : [s.n.], 2003. http://upetd.up.ac.za/thesis/available/etd-09052005-101713/.

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Chen, Chujian 1966. "Antitumor properties of kefir : possible bioactive component(s) and mechanism(s)". Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=85139.

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Research on the putative health benefits has indicated that kefir, a traditional fermented milk, might have antimutagenic and antitumor properties. The major objective of the present thesis was to isolate and identify antitumor compounds in cow's milk kefir and investigate the possible mechanisms involved. High speed centrifugation (HSC), molecular weight cut-off filtration (MWCO), size exclusion high performance liquid chromatography (SEC-HPLC) and reverse phase-HPLC (RP-HPLC) were utilized for fractionation of kefir and a cell culture model was developed to screen for the antiproliferative effects of the kefir fractions. The antiproliferative effects of bacteria-free extracts from different fermentation stages of kefir production, as well as bacteria-free extracts from milk and yogurt were compared. The results showed that extracts from an early stage of fermentation (i.e., kefir mother culture) and the final commercial kefir product both exerted dose-dependent inhibition effects on human mammary tumor MCF-7 cells, yogurt extracts showed less potent antiproliferative effects, while pasteurized milk extracts showed no antiproliferative effects. No antiproliferative effects of the kefir extracts were observed on human mammary epithelial cells (HMEC) whereas the yogurt extracts showed antiproliferative action in HMEC cells at a high dose. A fraction of the kefir mother culture isolated by HSC, MWCO and RP-HPLC contained components that inhibited MCF-7 cell growth and had no effect on HMEC cells. Characterization of the bioactive fraction using mass spectrometry (MS) indicated that the main components in the fraction are likely fragments of kefiran and/or ceramide containing compounds such as gangliosides. The growth inhibitory effect may be mainly caused by the induction of TNF-alpha in MCF-7 cells. Whole extracts of kefir depleted glutathione (GSH) in MCF-7 cells, while the SEC-HPLC Fraction 7 and the RP-HPLC Fraction 30 induced GSH produc

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Sun, Wai-yin Raymond, e 辛偉賢. "The antitumor and antiviral properties of gold (III) porphyrins and their related complexes". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31245973.

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Zhang, Zhouen. "Tumor-targeting antitumor prodrugs and noninvasive molecular imaging probes : designs, syntheses and properties". 京都大学 (Kyoto University), 2005. http://hdl.handle.net/2433/144557.

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Kyoto University (京都大学)
0048
新制・課程博士
博士(工学)
甲第11886号
工博第2579号
新制||工||1361(附属図書館)
23666
UT51-2005-N720
京都大学大学院工学研究科物質エネルギー化学専攻
(主査)教授西本清一, 教授中條善樹, 教授木村俊作
学位規則第4条第1項該当

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BUSA', Rosalia. "Evaluation of antitumor and immunomodulatory properties of Indicaxanthin from Opuntia Ficus Indica (L. Mill) fruit". Doctoral thesis, Università degli Studi di Palermo, 2020. http://hdl.handle.net/10447/395264.

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Cancer is a growing health problem around the world and according to estimates from the International Agency for Research on Cancer (IARC), 14.1 million new cancer cases and 8.2 million cancer deaths worldwide have been reported in 2012 (Ferlay et al., 2015). By 2030, the global burden is expected to grow to 21.7 million new cancer cases and 13 million cancer deaths simply due to the growth and aging of the population. Indicaxanthin ((2S)-2,3-dihydro-4-[2-[(2S)-2a-carboxypyrrolidin-1- yl]ethenyl]pyridine-2a,6-dicarboxylic acid), a betalain pigment from cactus pear fruit, has been the object of sound experimental work over the latest years. As many phytochemicals, indicaxanthin is a redox-active compound and has been shown to act as antioxidant in a number of in vitro studies (Allegra et al., 2005; Turco Liveri et al., 2009). Interestingly, thanks to its charged portions, ionizable groups and lipophilic moieties, it is amphiphilic at physiological pH (Turco Liveri et al., 2009) and has been demonstrated to interact with cell membranes (Tesoriere et al., 2006; Turco Liveri et al., 2009). This feature is critical to allow bioactive compounds to interact with cells and to initiate signaling events. In this regard, indicaxanthin has been showed to modulate specific redox-dependent signaling pathways involved in macrophage activation and apoptosis, epithelial and endothelial dysfunction in vitro (Allegra et al., 2014; Tesoriere et al., 2015). Remarkably, and in contrast with the majority of dietary phytochemicals, indicaxanthin is highly bioavailable (Tesoriere et al., 2004). The molecule has been shown to cross unaltered intestinal epithelial cell in vitro being absorbed through paracellular junctions (Tesoriere et al., 2013). In line with that, indicaxanthin has been found in human plasma at a 7 μM peak concentration 3 h after the ingestion of four cactus pear fruits containing 28 mg of the pigment (Tesoriere et al., 2004). Moreover, its amphiphilicity allows it to cross the blood-brain-barrier and localize within the CNS (Allegra et al., 2015). Finally, thanks to its bioavailability and redox-modulating properties, indicaxanthin exerts significant pharmacological effects in vivo. Indeed, oral administration of the PhC at nutritionally-relevant doses (2 μmol/kg) generates, in rats, a plasma peak concentration of 0.2 μM able to exert strong anti-inflammatory effects in an in vivo model of acute inflammation (Allegra et al., 2014). The causative link between inflammation and melanoma has accurately been explored in the recent years (Bald et al., 2014; Meyer et al., 2011; Reinhardt et al., 2017; Soudja et al., 2010). Experiments in mice revealed that UV-induced skin inflammatory responses can cause the reactive proliferation and migration of melanocytes (Zaidi et al., 2011). More recently, it has been shown that reciprocal interactions between melanoma and immune cells in a pro-inflammatory microenvironment provide a source of phenotypic heterogeneity that drives therapy resistance and metastasis (Bald et al., 2014; Landsberg et al., 2012). In keeping this perspective, we decided to investigate the effects of Indicaxanthin against human melanoma cell proliferation and in a model of cutaneous melanoma. We here demonstrate that indicaxanthin induces apoptosis of human melanoma cells through the inhibition of the NF-κB pathway and the downstream anti-apoptotic signaling events in vitro and these effects were paralleled in vivo in a murine model of melanoma. Finally, preliminary data on six healthy volunteers, showed that indicaxanthin is able to modulate TNF- and Il-6 production in a whole blood ex vivo model. Furthermore, the phytochemical induces an increase in the phagocytosis of 5 different Gram-negative pathogens on whole blood assay, without exerting antimicrobial effects on them. Interestingly, preliminary data on 4 of the 6 volunteers showed that the observed effects maybe attributed to the modulation of LTB4 levels, strictly correlated to the activation of immune cells.

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Medvetz, Douglas Allen. "The Synthesis, Characterization, and Antitumor Properties of Ag(I), Cu(II), and Rh(III) Metal Complexes". University of Akron / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1216840371.

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Libri sul tema "Antitumoral properties"

Fang, Evandro Fei, e Tzi Bun Ng, a cura di. Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6214-5.

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Antitumoral Properties of Natural Products. MDPI, 2020. http://dx.doi.org/10.3390/books978-3-03943-099-4.

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Antitumoral Properties of Natural Products. MDPI, 2020. http://dx.doi.org/10.3390/books978-3-03943-115-1.

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Antitumoral Properties of Natural Products. Mdpi AG, 2020.

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Fang, Evandro Fei, e Tzi Bun Ng. Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds. Springer, 2015.

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Fang, Evandro Fei, e Tzi Bun Ng. Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds. Springer, 2013.

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Fang, Evandro Fei, e Tzi Bun Ng. Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds. Springer, 2013.

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Fang, Evandro Fei, e Tzi Bun Ng. Antitumor Potential and Other Emerging Medicinal Properties of Natural Compounds. Springer London, Limited, 2013.

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Capitoli di libri sul tema "Antitumoral properties"

Varela, João, Catarina Vizetto-Duarte, Luísa Custódio, Luísa Barreira e Fernando Albericio. "Marine Peptides and Proteins with Cytotoxic and Antitumoral Properties". In Marine Proteins and Peptides, 407–30. Chichester, UK: John Wiley & Sons, Ltd, 2013. http://dx.doi.org/10.1002/9781118375082.ch19.

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Schumann, G. "Antiviral and Antitumor Effects of Liposome-Entrapped MTP-PE, a Lipophilic Muramylpeptide". In Biological Properties of Peptidoglycan, a cura di Peter H. Seidl e Karl H. Schleifer, 255–60. Berlin, Boston: De Gruyter, 1986. http://dx.doi.org/10.1515/9783110874297-032.

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Malik, Fayaz, e Suresh Kumar. "Sesquiterpenes from Essential Oils with Promising Antitumor Properties". In Bioactive Essential Oils and Cancer, 201–14. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-19144-7_9.

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Attaway, John A. "Citrus Juice Flavonoids with Anticarcinogenic and Antitumor Properties". In ACS Symposium Series, 240–48. Washington, DC: American Chemical Society, 1993. http://dx.doi.org/10.1021/bk-1994-0546.ch019.

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Köpf-Maier, P. "Organometallic Titanocene and Ferricenium Complexes: Antitumor and Toxicologic Properties". In Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy, 601–11. Boston, MA: Springer US, 1988. http://dx.doi.org/10.1007/978-1-4613-1717-3_66.

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Silbert, Jeremiah. "Lectins: Personal Comments of Nathan Sharon Taken from his Memoirs (Translation from Hebrew)". In Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds, 3–11. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6214-5_1.

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Vago, Riccardo, Rodolfo Ippoliti e Maria Serena Fabbrini. "Current Status and Biomedical Applications of Ribosome-Inactivating Proteins". In Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds, 145–79. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6214-5_10.

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Kennedy, Ann R. "The Health Benefits of the Bowman-Birk Inhibitor". In Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds, 183–86. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6214-5_11.

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Rolka, Krzysztof, Adam Lesner, Anna Łęgowska e Magdalena Wysocka. "Peptidic Inhibitors of Serine Proteinases of Plant Origin". In Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds, 187–204. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6214-5_12.

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Furukawa, Kenei, Tadashi Uwagawa e Katsuhiko Yanaga. "Anti-Tumor Effect of Synthetic Serine Protease Inhibitor". In Antitumor Potential and other Emerging Medicinal Properties of Natural Compounds, 205–12. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-6214-5_13.

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Atti di convegni sul tema "Antitumoral properties"

Bezerra, Natércia M. M., Gardênia C. G. Militão, Terezinha G. da Silva, Paulo H. Menezes e Roberta A. Oliveira. "Synthesis of Combretastatin A-4 Analogs with Antitumoral Properties". In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0272-1.

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Lázaro, Rocío S. García, Humberto Lamdan, Norailys Lorenzo Perez, Lorena G. Caligiuri, Andrea L. Berengeno, Hugo H. Ortega, Daniel F. Alonso e Hernan G. Farina. "Abstract 3455: Preclinical evidences of antitumoral properties of a Yerba mate extract on breast and colon cancer models". In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-3455.

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Yu, Henry, Hong-Ming Hu, Rongliang Lou, Wanping Geng, Sanlong Wang, William Redmond, Yoshinobu Koguchi, Baotian Qin, John Mao e Shaoshan Wang. "1171 CAN1012: a selective and potent TLR7 agonist with strong antitumoral properties mediated by localized innate immune activation". In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.1171.

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Tikhonov, Sergey, Nataliya Tikhonova, N. V. Merzlyakova e A. S. Ozhgihina. "PEPTIDES AS A FUNCTIONAL INGREDIENT FOR PREVENTIVE PRODUCTS". In I International Congress “The Latest Achievements of Medicine, Healthcare, and Health-Saving Technologies”. Kemerovo State University, 2023. http://dx.doi.org/10.21603/-i-ic-133.

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Clinical studies indicate that products from cow colostrum are well tolerated by the human body, non-toxic and safe for consumption. The aim of this study is to study the antitumor properties of isolated individual peptides from corvine colostrum on the cell line of rat glioblastoma C6. The study revealed that peptide R1 has antitumor activity, therefore it can be used as a functional ingredient in food products.

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Patlay, A. A., M. E. Shmelev, V. E. Silant’ev e A. S. Belousov. "CREATION AND CHARACTERIZATION OF HYDROGELS BASED ON MODIFIED PECTINS WITH CUSTOMIZABLE PROPERTIES FOR THE THERAPY OF BRAIN TUMORS". In X Международная конференция молодых ученых: биоинформатиков, биотехнологов, биофизиков, вирусологов и молекулярных биологов — 2023. Novosibirsk State University, 2023. http://dx.doi.org/10.25205/978-5-4437-1526-1-112.

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We have developed pectin hydrogels and coatings suitable for remodeling the extracellular matrix of the central nervous system with adjustable viscoelastic and structural properties. Hydrogels have shown antitumor effect on glioblastoma C6 and U87MG cultures by reducing cell proliferation and migration, which makes them promising materials for combination therapy of glioma.

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Čolović, Mirjana B., Lela B. Korićanac, Jelena J. Žakula, Nada Savić, Tatjana Parac-Vogt e Danijela Z. Krstić. "The influence of Fe(III) incorporation on anti-cancer potential of a Wells- Dawson nanocluster". In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.419c.

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The objective of this study was to evaluate in vitro the antitumor properties of Fe(III)-substituted monolacunary Wells-Dawson polyoxotungstate, K7[FeIII(α2-P2W17O61)(H2O)] (FeWD) using cervical carcinoma HeLa cells as a model system. HeLa cells were exposed in vitro to FeWD within the concentration range from 0.001 to 1 mM, for 24, 48, and 72 hours. The studied Fe(III)- substituted polyoxotungstate affected HeLa cell viability in a concentration- and time-dependent manner. The obtained IC50 values (μM), as an indicator of the cytotoxic potential of FeWD, were: 16.64 ± 0.49, 10.75 ± 0.97, and 9.64 ± 0.19 for 24-, 48-, and 72-hour treatment, respectively. FeWD exhibited a stronger antitumor potential against HeLa cells than the structurally similar monolacunary Wells-Dawson polyoxotungstate, K10P2W17O61.20H2O (lacunary WD). Lacunary WD achieved IC50 at 24,11 μM after 24-hour exposure, which is about 44% higher concentration compared to the corresponding IC50 obtained for FeWD. This indicates that incorporating Fe(III) might be a new strategy for improving the antitumor efficacy of polyoxometalates as promising candidates for next-generation chemotherapeutics.

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Dezvareh, Homa. "Abstract 5319: Apoptotic properties of platinum antitumor agents phosphaplatins". In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-5319.

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Cibotaru, Sandu, Andreea-Isabela Sandu, Dalila Belei e Luminita Marin. "Water Soluble PEGylated phenothiazines. Synthesis, Characterization and Antitumor Properties". In The First International Conference on “Green” Polymer Materials 2020. Basel, Switzerland: MDPI, 2020. http://dx.doi.org/10.3390/cgpm2020-07215.

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Antosyuk, O. N., e E. V. Bolotnik. "CHANGES VIABILITY INDICATORS OF DROSOPHILA MELANOGASTER WHEN USING EXTRACTS REPRESENTATIVES OF THE GENUS MONARDA REGARDING INFLUENCE ANTI-TUMOR DRUGS". In I International Congress “The Latest Achievements of Medicine, Healthcare, and Health-Saving Technologies”. Kemerovo State University, 2023. http://dx.doi.org/10.21603/-i-ic-7.

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In the course of the analysis of the protective properties of representatives of the genus Monarda, in relation to the antitumor drug methotrexate, a decrease in the lethality of Drosophila melanogaster individuals was found with the simultaneous use of this drug and M. fistulosa extract (100 mg/ml). With regard to exposure to etoposide, protective properties in terms of lethality were determined for extracts of M. fistulosa var. menthifolia and M. didyma.

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Orel, V. E., O. Y. Rykhalskyi, A. Melnyk, A. Shevchuk, A. V. Romanov, A. D. Shevchenko, A. P. Burlaka e S. M. Lukin. "Device for synthesis of antitumor nanocomplex with fixed magnetic properties". In 2017 IEEE 37th International Conference on Electronics and Nanotechnology (ELNANO). IEEE, 2017. http://dx.doi.org/10.1109/elnano.2017.7939813.

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