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Letteratura scientifica selezionata sul tema "Antisense nucleic acids"

Autore: Grafiati

Pubblicato: 4 giugno 2021

Ultima modifica: 1 agosto 2024

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Articoli di riviste sul tema "Antisense nucleic acids"

1

Goodchild, John. "Antisense nucleic acids and proteins". Cell Biophysics 18, n. 3 (giugno 1991): 295–96. http://dx.doi.org/10.1007/bf02989820.

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2

Razzak, Mina. "Antisense nucleic acids—tough delivery". Nature Reviews Urology 10, n. 12 (19 novembre 2013): 681. http://dx.doi.org/10.1038/nrurol.2013.271.

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3

Penchovsky, Robert, Antoniya V. Georgieva, Vanya Dyakova, Martina Traykovska e Nikolet Pavlova. "Antisense and Functional Nucleic Acids in Rational Drug Development". Antibiotics 13, n. 3 (27 febbraio 2024): 221. http://dx.doi.org/10.3390/antibiotics13030221.

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Abstract (sommario):

This review is focused on antisense and functional nucleic acid used for completely rational drug design and drug target assessment, aiming to reduce the time and money spent and increase the successful rate of drug development. Nucleic acids have unique properties that play two essential roles in drug development as drug targets and as drugs. Drug targets can be messenger, ribosomal, non-coding RNAs, ribozymes, riboswitches, and other RNAs. Furthermore, various antisense and functional nucleic acids can be valuable tools in drug discovery. Many mechanisms for RNA-based control of gene expression in both pro-and-eukaryotes and engineering approaches open new avenues for drug discovery with a critical role. This review discusses the design principles, applications, and prospects of antisense and functional nucleic acids in drug delivery and design. Such nucleic acids include antisense oligonucleotides, synthetic ribozymes, and siRNAs, which can be employed for rational antibacterial drug development that can be very efficient. An important feature of antisense and functional nucleic acids is the possibility of using rational design methods for drug development. This review aims to popularize these novel approaches to benefit the drug industry and patients.

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4

Soomets, Ursel. "Antisense properties of peptide nucleic acids". Frontiers in Bioscience 4, n. 1-3 (1999): d782. http://dx.doi.org/10.2741/soomets.

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5

Langel, Ülo. "Antisense properties of peptide nucleic acids". Frontiers in Bioscience 4, n. 4 (1999): d782–786. http://dx.doi.org/10.2741/a394.

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6

Tonkinson, J. L., e C. A. Stein. "Antisense Nucleic Acids — Prospects for Antiviral Intervention". Antiviral Chemistry and Chemotherapy 4, n. 4 (agosto 1993): 193–200. http://dx.doi.org/10.1177/095632029300400401.

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Antisense oligodeoxynucleotides are a promising new class of antiviral agent. Because they bind in a sequence-specific manner to complementary regions of mRNA, oligos can inhibit gene expression in a sequence-specific manner. The ‘antisense’ approach has been used successfully to block cellular expression and replication of several viruses including Human Immunodeficiency Virus-1 (HIV-1), and Herpes Simplex Virus (HSV). However, the antiviral effect of oligodeoxynucleotides is not limited to sequence-specific inhibition of gene expression. Non sequence-specific effects are frequently observed, presumably as a result of their properties as polyanions. Occasionally (e.g. for HIV-1) these non sequence-specific effects are also therapeutic. The prospects for antisense oligodeoxynucleotide therapy for viral disease are discussed.

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Morihiro, Kunihiko, Yuuya Kasahara e Satoshi Obika. "Biological applications of xeno nucleic acids". Molecular BioSystems 13, n. 2 (2017): 235–45. http://dx.doi.org/10.1039/c6mb00538a.

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8

Malcolm, Alan D. B. "Uses of antisense nucleic acids — an introduction". Biochemical Society Transactions 20, n. 4 (1 novembre 1992): 745–46. http://dx.doi.org/10.1042/bst0200745.

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9

Flores, Maria Vega C., David Atkins, Thomas Stanley Stewart, Arthur van Aerschot e Piet Herdewijn. "Antimalarial antisense activity of hexitol nucleic acids". Parasitology Research 85, n. 10 (24 agosto 1999): 864–66. http://dx.doi.org/10.1007/s004360050647.

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10

Nielsen, Peter. "Targeting structured nucleic acids with antisense agents ▾". Drug Discovery Today 8, n. 10 (maggio 2003): 440. http://dx.doi.org/10.1016/s1359-6446(03)02702-8.

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Tesi sul tema "Antisense nucleic acids"

1

Abbas, Sahar. "Design and synthesis of backbone-modified nucleic acids". Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368273.

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2

Bijapur, Jeevan. "Factors affecting the stability of nucleic acids". Thesis, University of Southampton, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299497.

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3

Slaitas, Andis. "Development of a new PNA analogue as a potential antisense drug and tool for life-science studies /". Stockholm : Karolinska institutet, 2004. http://diss.kib.ki.se/2004/91-7349-642-1/.

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4

Dryselius, Rikard. "Bacterial gene expression inhibition with antisense peptide nucleic acids /". Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-338-8/.

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Dysko, Anna Monika. "Synthesis and properties of oligonucleotides containing triazole backbone linkages and 2'-modifications for therapeutic applications". Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:20fc1203-9751-4654-b497-5f4d97f874a1.

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Abstract (sommario):

Antisense oligonucleotides are short strands of DNA, which bind to their complementary mRNA target to prevent protein translation. Although conceptually appealing, for their practical use as drugs, these oligonucleotides must have better cellular uptake, resistance to enzymatic degradation, and target selectivity. In this work, new synthetic chemistry is established to prepare a novel group of chemically modified oligonucleotides. The anionic phosphodiester backbone is partially replaced with a neutral triazole and, at the same time, the 2'-position of the ribose sugar is functionalised with pyrene, anthraquinone, or guanidine moieties. Being unnatural, the triazole backbone is inherently resistant to enzymatic degradation, while the reduced negative charge potentially improves cell penetration. The limitation of introduction of a triazole backbone into the antisense strand is its destabilising effect on the duplex formation with their complementary target. In this study, the 2'-modifications are used to restore the lost duplex stability and they have been found to be very efficient stabilising moieties. To evaluate the viability of this strategy, reporter gene assays based on splice-switching model are used. Promisingly, these modified oligonucleotides have successfully shown antisense splice-switching activity, suggesting there is further scope for their improvement.

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6

Lewis, Karen Jane. "Biodegradable polymers for the sustained release of antisense nucleic acids". Thesis, Aston University, 1996. http://publications.aston.ac.uk/11054/.

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Antisense oligodeoxynucleotides can selectively inhibit individual gene expression provided they remain stable at the target site for a sufficient period of time. Thus, the efficacy of antisense oligodeoxynucleotides may be improved by employing a sustained release delivery system which would protect from degradation by nucleases whilst delivering the nucleic acid in a controlled manner to the site of action. Biodegradable polymer films and micro spheres were evaluated as delivery devices for the oligodeoxynucleotides and ribozymes. Polymers such as polylactide, polyglycolide, polyhydroxybutyrate and polyhydroxyvalerate were used due to their biocompatability and non toxic degradation products. Release profiles of antisense nucleic acids from films over 28 days was biphasic, characterised by an initial burst release during the first 48 hours followed by a more sustained release. Release from films of longer antisense nucleic acids was slower compared to shorter nucleic acids. Backbone type also affected release, although to a lesser extent than length. Total release of the nucleic acids is dependent upon polymer degradation, no degradation of the polymer films was evident over the 28 day period, due to the high molecular weight and crystallinity of the polymers required to make solvent cast films. Backbone length and type did not affect release from microspheres, release was generally faster than from films, due to the increased surface area, and low molecular weight polymers which showed signs of degradation over the release period, resulting in a triphasic release profile. An increase in release was observed when sphere size and polymer molecular weight were decreased. The polymer entrapped phosphodiester oligodeoxynucleotides and ribozymes had enhanced stability compared to free oligodeoxynucleotides and ribozymes when incubated in serum. The released nucleic acids were still capable of hybridising to their target sequence, indicating that the fabrication processes did not adversely effect the properties of the antisense nucleic acids. Oligodeoxynucleotides loaded in 2μm spheres had a 10 fold increase in macrophage association compared to free oligodeoxynucleotides. Fluorescent microscopy indicates that the polymer entrapped oligodeoxynucleotide is concentrated inside the cell, whereas free oligodeoxynucleotides are concentrated at the cell membrane. Biodegradable polymers can reduce the limitations of antisense therapy and thus offer a potential therapeutic advantage.

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Dong, Shuzhi Dong Shuzhi. "I. Restriction of DNA conformation by spirocyclic annulation at C-4' II. Studies toward the enantioselective synthesis of pestalotiopsin A /". Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1174627553.

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Silvester, Nicole Cherie. "Terminal Modifications of PNA and Their Use in Diagnostic and Antisense Technologies". Thesis, Griffith University, 2008. http://hdl.handle.net/10072/366991.

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Abstract (sommario):

Peptide nucleic acids (PNA) are analogues of DNA that bind to DNA and RNA via Watson-Crick base-pairing rules. Due to the lack of a negatively-charged backbone, hybridisation of PNA to DNA or RNA occurs without electrostatic repulsion thus binding is typically stronger and more rapid than when traditional DNA probes are used. This is reflected in the increased melting temperature (Tm) of the conjugates. These properties, as well as the chemical and biological stability of PNA, make these molecules attractive for use in diagnostic and therapeutic applications. Amino acids are routinely conjugated to PNA probes to enhance the synthesis and solubility of the probes or assist with their cellular delivery, however little thought is given to the impact these modifications have on their hybridisation properties. In this work, a series of PNA-peptide chimeric assemblies based around a single PNA sequence were used to investigate the effect different amino acids have on the stability and specificity of PNA/DNA hybridisation. These experiments demonstrated that the positively charged amino acid lysine, which is routinely conjugated to PNA probes, increases the stability of the resultant PNA/DNA duplexes such that at many experimental temperatures, single base mismatched target DNA will also stably hybridise with PNA. In contrast, the negatively charged amino acid glutamic acid decreases the thermal stability of the mismatch duplexes sufficiently so that they are not stable at most experimental temperatures, whilst the fully complementary duplex is. This indicates that glutamic acid should replace lysine as the routine solubility enhancing group used for PNA probes.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Physical Sciences
Science, Environment, Engineering and Technology
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9

Xu, Jian, e 徐堅. "Using antisense oligonucleotide in whole embryo culture to study gene interactions during mouse gastrulation". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31220150.

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Xu, Jian. "Using antisense oligonucleotide in whole embryo culture to study gene interactions during mouse gastrulation /". Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19918884.

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Più fonti

Libri sul tema "Antisense nucleic acids"

1

1947-, Brakel Christine L., a cura di. Discoveries in antisense nucleic acids. The Woodlands, Tex: Portfolio Pub. Co., 1989.

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2

A, Stein Cy, e Krieg Arthur M, a cura di. Applied antisense oligonucleotide technology. New York: Wiley-Liss, 1998.

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3

Ian, Phillips M., a cura di. Antisense therapeutics. 2^a ed. Totowa, N.J: Humana Press, 2005.

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4

Ian, Phillips M., a cura di. Antisense therapeutics. 2^a ed. Totowa, N.J: Humana Press, 2005.

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5

1966-, Hartmann Gunther, e Endres Stefan 1957-, a cura di. Manual of antisense methodology. Boston: Klwuer Academic, 1999.

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6

Renato, Baserga, e Denhardt David T, a cura di. Antisense strategies. New York: New York Academy of Sciences, 1992.

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7

T, Crooke Stanley, a cura di. Antisense drug technology: Principles, strategies, and applications. 2^a ed. Boca Raton: Taylor & Francis, 2006.

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8

Sudhir, Agrawal, a cura di. Antisense therapeutics. Totowa, N.J: Humana Press, 1996.

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9

Mol, Joseph N. M., 1948- e Krol, Alexander R. van der, 1956-, a cura di. Antisense nucleic acids and proteins: Fundamentals and applications. New York: M. Dekker, 1991.

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10

Ian, Phillips M., a cura di. Antisense technology: General methods, methods of delivery and RNA studies. San Diego, CA: Academic Press, 1999.

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Capitoli di libri sul tema "Antisense nucleic acids"

1

Houba-Hérin, N., e M. Inouye. "Antisense RNA". In Nucleic Acids and Molecular Biology, 210–20. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-46596-3_13.

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2

Goh, Shan, Jem Stach e Liam Good. "Antisense Effects of PNAs in Bacteria". In Peptide Nucleic Acids, 223–36. Totowa, NJ: Humana Press, 2013. http://dx.doi.org/10.1007/978-1-62703-553-8_18.

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3

Goltermann, Lise, e Peter E. Nielsen. "PNA Antisense Targeting in Bacteria: Determination of Antibacterial Activity (MIC) of PNA-Peptide Conjugates". In Peptide Nucleic Acids, 231–39. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-0716-0243-0_14.

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4

Liang, Xue-hai, Timothy A. Vickers e Stanley T. Crooke. "Antisense-Mediated Reduction of Eukaryotic Noncoding RNAs". In From Nucleic Acids Sequences to Molecular Medicine, 191–214. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-27426-8_8.

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5

Eritja, Ramon, Montserrat Terrazas, Santiago Grijalvo, Anna Aviñó, Adele Alagia, Sónia Pérez-Rentero e Juan Carlos Morales. "Challenges and Opportunities for Oligonucleotide-Based Therapeutics by Antisense and RNA Interference Mechanisms". In Chemical Biology of Nucleic Acids, 227–42. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-54452-1_13.

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6

Magistri, Marco, e Mohammad Ali Faghihi. "Natural Antisense Transcripts Mediate Regulation of Gene Expression". In From Nucleic Acids Sequences to Molecular Medicine, 247–74. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-27426-8_10.

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7

Caruso, Gerardo, Mariella Caffo, Giuseppe Raudino, Federica Raudino, Mario Venza e Francesco Tomasello. "Antisense Oligonucleotides in the Treatment of Malignant Gliomas". In From Nucleic Acids Sequences to Molecular Medicine, 215–46. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-27426-8_9.

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8

Gait, Michael J., e Sudhir Agrawal. "Introduction and History of the Chemistry of Nucleic Acids Therapeutics". In Methods in Molecular Biology, 3–31. New York, NY: Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2010-6_1.

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AbstractThis introduction charts the history of the development of the major chemical modifications that have influenced the development of nucleic acids therapeutics focusing in particular on antisense oligonucleotide analogues carrying modifications in the backbone and sugar. Brief mention is made of siRNA development and other applications that have by and large utilized the same modifications. We also point out the pitfalls of the use of nucleic acids as drugs, such as their unwanted interactions with pattern recognition receptors, which can be mitigated by chemical modification or used as immunotherapeutic agents.

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Di Cresce, Christine, Colin Way, Mateusz Rytelewski, Saman Maleki Vareki, Supritha Nilam, Mark D. Vincent, James Koropatnick e Peter J. Ferguson. "Antisense Technology: From Unique Laboratory Tool to Novel Anticancer Treatments". In From Nucleic Acids Sequences to Molecular Medicine, 145–89. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-27426-8_7.

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10

Stetsenko, Dmitry A. "Mesyl Phosphoramidate Oligonucleotides: A New Promising Type of Antisense Agents". In Handbook of Chemical Biology of Nucleic Acids, 1–41. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-16-1313-5_19-1.

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Atti di convegni sul tema "Antisense nucleic acids"

1

Van Aerschot, Arthur, Mark Vandermeeren, Johan Geysen, Walter Luyten, Marc Miller, David Atkins, Sonia Preveral, Ester Saison-Behmoaras e Piet Herdewijn. "In vitro evaluation of hexitol nucleic acid antisense oligonucleotides". In XIth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199902151.

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2

Marzenell, Paul D., Helen Hagen, Larisa Kovbasyuk e Andriy Mokhir. "Chemically modified phosphorothioate DNA and 2'-OMe RNA as antisense agents". In XVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112391.

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3

Wojtczak, Blazej A., Agnieszka Andrysiak e Zbigniew J. Lesnikowski. "An approach towards synthesis of antisense oligonucleotides modified with lipophilic boron clusters via "click chemistry" method". In XIVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810482.

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4

Ravn, Jacob, Maj Hedtjärn, Niels Fisker, Joachim Elmén, Marie W. Lindblom, Henrik F. Hansen, Michael Meldgaard, Ellen M. Straarup, Jens B. Hansen e Christoph Rosenbohm. "Locked nucleic acid antisense oligonucleotides targeting apolipoprotein B: the effect of short sequences and α-L-LNA insertion". In XVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112444.

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5

Greco, Francesca, Elena Cesaro, Andrea Falanga, Rosa Catapano, Simona Romano, Nicola Borbone, Arianna Pastore et al. "A novel antisense strategy peptide nucleic acid-based to downregulate CD5 expression in chronic lymphocytic leukemia". In 7th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/ecmc2021-11396.

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6

Levin, Arthur A., Lee M. Greenberger, Aby Buchbinder, Bo R. Hansen, Maj Hedtjärn, Sakari Kauppinen, Henrik Oerum e Ivan D. Horak. "Abstract SY31-02: Locked nucleic acid (LNA)-modified antisense oligonucleotides as anticancer agents: Using high-affinity antisense molecules in the laboratory and in the clinic". In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-sy31-02.

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Brown, Paige K., Ammar T. Qureshi, Daniel J. Hayes e W. Todd Monroe. "Targeted Gene Silencing With Light and a Silver Nanoparticle Antisense Delivery System". In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53647.

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Abstract (sommario):

Targeted delivery and controlled release of oligonucleotide therapeutics in vivo are essential aspects of an ideal delivery vehicle. Here we demonstrate the synthesis and in vitro/intracellular characterization of silver nanoparticle (SNP) photolabile nucleic acid conjugates, with the aim of developing a nanoparticulate platform for inducible gene silencing. Due to unique size related properties, nanostructures are being increasingly utilized for intracellular diagnostics and delivery applications. While most nanoscale delivery platforms are polymeric in composition, studies of metallic nanoparticles have highlighted their suitability for delivery of therapeutic agents such as antisense oligonucleotides [1]. The potential benefits of noble metal nanoparticles in delivery applications include tunable size and shape, ease of bulk synthesis and functionalization via ‘wet chemistry’ techniques, and enhanced stability of tethered DNA [2]. Silver is one of the best surface-enhancing substrates available for nanostructure synthesis [3]. SNP composites afford external control over surface-tethered drug release via external triggers.

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Thomas, Sufi M., Shrinivas Rapiredd, Bichismita Sahu, Sonali Joyce e Danith Ly. "Abstract C175: Antisense EGFR guanidium‐based peptide nucleic acid (GPNA) oligomers as an antitumor agent for head and neck cancer". In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-c175.

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Klar, Richard, Clara Seger, Nicole Kirchhammer, André Maaske, Julia Festag, Laura Fernandez Rodriguez, Mélanie Buchi et al. "434 Targeting the expression of Neuropilin-1 by locked nucleic acid modified antisense oligonucleotides results in potent anti-tumor activity in vivo". In SITC 37th Annual Meeting (SITC 2022) Abstracts. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-sitc2022.0434.

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Sapra, Puja, Yixian Zhang, Stephen Castaneda, Steven Kim, Patricia Kraft, Raj Bandaru, Lee M. Greenberger e Ivan D. Horak. "Abstract C144: A locked nucleic acid antisense oligonucleotode against androgen receptor, down‐modulates target mRNA and causes antitumor effects in xenograft models of prostate cancer". In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 15-19, 2009; Boston, MA. American Association for Cancer Research, 2009. http://dx.doi.org/10.1158/1535-7163.targ-09-c144.

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