Articoli di riviste: "Antibacterial and anti-Adhesive properties"

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Sautrot-Ba, P., N. Razza, L. Breloy, S. Abbad Andaloussi, A. Chiappone, M. Sangermano, C. Hélary, S. Belbekhouche, T. Coradin e D. L. Versace. "Photoinduced chitosan–PEG hydrogels with long-term antibacterial properties". Journal of Materials Chemistry B 7, n. 42 (2019): 6526–38. http://dx.doi.org/10.1039/c9tb01170f.

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Kudryavtseva, Yulia A., Anastasia Yu Kanonykina, Daria K. Shishkova, Natalia A. Efremova, Pavel S. Onishchenko e Leonid S. Barbarash. "BIODEGRADABLE ANTI-ADHESIVE MEMBRANES WITH ANTIBACTERIAL PROPERTIES FOR USE IN SURGERY". Complex Issues of Cardiovascular Diseases 12, n. 4S (29 dicembre 2023): 80–89. http://dx.doi.org/10.17802/2306-1278-2023-12-4s-80-89.

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HighlightsAdhesion formation is a classic complication of any surgical intervention, which reduces the quality of life of patients and carries the risk of fatal complications during repeated surgery. Moreover, there is an issue of postoperative wound infection. Currently, there are no effective anti-adhesive agents with antibacterial activity in the arsenal of surgeons. Aim. To justify and develop biodegradable anti-adhesive membranes with antibacterial activity.Methods. The membranes were made by electrospinning using a composition of biodegradable polymers: polylactide-co-glycolide copolymer (50:50) Mm 20–30 KDa and ε-caprolactonone. The antibiotic Tigacil was added to the polymer solution to impart antibacterial properties to the membrane. The surface structure of the membranes was evaluated using a scanning electron microscope. Physical, mechanical and hemocompatibility properties were studied. The antibacterial activity of the membranes was evaluated after manufacturing, sterilization and storage for 24 months.Results. The inclusion of Tigacil in the membrane composition contributed to a decrease in fiber thickness by almost 4 times, while the packing of fibers became denser, which affected the increase in the strength of the modified membranes. Samples of membranes before and after the inclusion of Tigacil have no negative effect on erythrocytes The obtained results confirm the antibacterial activity of membranes against Staphylococcus aureus and Klebsiella pneumoniae, as well as the preservation of these properties after sterilization and during 2 years of storage.Conclusion. The inclusion of Tigacil in the polymer composition makes it possible to create biodegradable anti-adhesive membranes with antibacterial activity, which is maintained for two years after the manufacture. The inclusion of Tigacil in the polymer fiber composition does not adversely affect the initial properties of the membrane.

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Morgan, T. D., e M. Wilson. "Anti-adhesive and antibacterial properties of a proprietary denture cleanser". Journal of Applied Microbiology 89, n. 4 (ottobre 2000): 617–23. http://dx.doi.org/10.1046/j.1365-2672.2000.01158.x.

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Kharouf, Naji, Ammar Eid, Louis Hardan, Rim Bourgi, Youri Arntz, Hamdi Jmal, Federico Foschi et al. "Antibacterial and Bonding Properties of Universal Adhesive Dental Polymers Doped with Pyrogallol". Polymers 13, n. 10 (11 maggio 2021): 1538. http://dx.doi.org/10.3390/polym13101538.

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This study investigated the antibacterial activity, bond strength to dentin (SBS), and ultra-morphology of the polymer–dentin interface of experimental adhesive systems doped with pyrogallol (PY), which is a ubiquitous phenolic moiety that is present in flavonoids and polyphenols. A universal adhesive containing 4-META and 10-MDP was used in this study. PY behaves as an antioxidant and anti-cancerogenic agent and it was incorporated into the adhesive at different concentrations (0.5 and 1 wt.%). The antibacterial activity and SBS were analyzed and the results were statistically analyzed. The ultra-morphology of the polymer–dentin interface was assessed using scanning electron microscopy (SEM). At 24 h, a lower antibacterial activity was observed for the control adhesive compared to those with 0.5% and 1% PY. No difference was seen in SBS between the three groups at 24 h. After 6 months, the SBS of the 0.5% PY adhesive was significantly lower than the other tested adhesives. The specimens created with 1% PY adhesive presented a higher bond strength at six months compared with that found at 24 h. No morphological differences were found at the polymer–dentin interfaces of the tested adhesives. Pyrogallol may be incorporated into modern universal adhesive systems to preserve the polymer–dentin bonding interface and confer a certain degree of antibacterial activity.

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Latif, Irina I., Aleksandr M. Kovalevsky, Lyudmila A. Kraeva, Maria A. Nosova e Aleksey N. Sharov. "THE EFFECTIVENESS OF THE COMPOSITION IN THE FORM OF GEL FOR ORAL CARE WITH HERBAL COMPONENTS". Applied Information Aspects of Medicine (Prikladnye informacionnye aspekty mediciny) 26, n. 2 (1 luglio 2023): 59–66. http://dx.doi.org/10.18499/2070-9277-2023-26-2-59-66.

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The article discusses the results of a clinical and microbiological study of the anti-plaque, anti-inflammatory, hemostatic, antibacterial and anti-adhesive effects of the developed composition in the form of a gel for the care of oral tissues based on aspen bark extract, chlorophyll, dihydroquercitin, D-panthenol, methyl salicylate, the effect of this complex on the pH level of the gingival fluid, the results of a microbiological study to determine the survival of microorganisms such as Streptococcus sanguinis, Streptococcus mitis, Streptococcus oralis, Streptococcus salivarius, Staphylococcus aureus, Enterococcus faecalis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, the results of determining the adhesive properties of S. Sanguinis in the presence of a gel composition, the effectiveness of the reduction action indices ONi-S, SBI, PMA, changes in the pH level of gingival fluid, antibacterial and anti-adhesive efficiancy.

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NYAMBE, MOLLA MARITHA, RENATE HANS, MERVYN BEUKES, JANE MORRIS e MARTHA KANDAWA-SCHULZ. "Phytochemical and antibacterial analysis of indigenous chewing sticks, Diospyros lyciodes and Euclea divinorum of Namibia". Biofarmasi Journal of Natural Product Biochemistry 16, n. 1 (1 febbraio 2018): 29–43. http://dx.doi.org/10.13057/biofar/f160104.

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Nyambe MM. 2018. Phytochemical and antibacterial analysis of indigenous chewing sticks, Diospyros lyciodes and Euclea divinorum of Namibia. Biofarmasi 16: 29-43. The purpose of this study was to ascertain the phytochemical and antibacterial properties of Diospyros lycioides and Euclea divinorum and correlate the results obtained to their ethnomedicinal uses as chewing sticks. Fractions of powdered leaves, twigs, and roots were obtained from crude extracts using vacuum liquid chromatography with solvents of increasing polarity. Antimicrobial activities of the crude extracts and fractions were assessed using the agar overlay, disc diffusion, and agar dilution methods against the oral pathogens, Streptococcus mutans and Streptococcus sanguinis. In addition, the effect of fractions on the attachment of oral pathogens to tooth surface were also analyzed using saliva-coated hydroxyapatite beads (S-HA) as a model. Phytochemical screen tests revealed the presence of the following secondary metabolites in the twigs and roots of both plants: anthraquinones, cardenolides, saponins, tannins, polyphenols, and terpenoids. Alkaloids were detected only in the roots of both plants. Root fractions from both plants displayed higher antibacterial activity than twig fractions. This supports the preference of roots over twigs by stick users. D. lycioides root fraction displayed minimum inhibitory concentrations (MICs) of 0.625 mg/mL and 1.25 mg/mL against S. sanguinis and S. mutans, respectively. E. divinorum root fraction showed MICs of 1.25 mg/mL and 2.5 mg/mL against the aforementioned organisms. Adherence of the bacteria to S-HA was reduced more by root fractions from D. lycioides while twig fractions from both plants also showed significant anti-adhesive properties. Since fractions from both plants inhibited the growth of bacteria and reduced attachment to S-HA, it is an indication that these plants are potential sources of antibacterial and anti-adhesive agents and their use should be encouraged. The anti-adhesive activity of extracts from these plants has not yet being reported. Further research on isolation and characterization of the active compounds from fractions that showed antibacterial and anti-adhesive activity is recommended.

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Aguilar-Perez, David Alejandro, Cindy Maria Urbina-Mendez, Beatriz Maldonado-Gallegos, Omar de Jesus Castillo-Cruz, Fernando Javier Aguilar-Ayala, Martha Gabriela Chuc-Gamboa, Rossana Faride Vargas-Coronado e Juan Valerio Cauich-Rodriguez. "Mechanical Properties of Poly(Alkenoate) Cement Modified with Propolis as an Antiseptic". Polymers 15, n. 7 (28 marzo 2023): 1676. http://dx.doi.org/10.3390/polym15071676.

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Background: We assessed the effect of propolis on the antibacterial, mechanical, and adhesive properties of a commercial poly(alkenoate) cement. Methods: The cement was modified with various concentrations of propolis, and antibacterial assays were performed against S. mutans by both MTT assays and agar diffusion tests. The compressive, flexural, and adhesive properties were also evaluated. Results: the modified cement showed activity against S. mutans in both assays, although reductions in compressive (from 211.21 to 59.3 MPa) and flexural strength (from 11.1 to 6.2 MPa) were noted with the addition of propolis, while adhesive strength (shear bond strength and a novel pull-out method) showed a statistical difference (p < 0.05). Conclusion: the antiseptic potential of modified material against S. mutans will allow this material to be used in cases in which low mechanical resistance is required (in addition to its anti-inflammatory properties) when using atraumatic restorative techniques, especially in deep cavities.

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Münchow, Eliseu A., Adriana F. da Silva, Evandro Piva, Carlos E. Cuevas-Suárez, Maria T. P. de Albuquerque, Rodolfo Pinal, Richard L. Gregory, Lorenzo Breschi e Marco C. Bottino. "Development of an antibacterial and anti-metalloproteinase dental adhesive for long-lasting resin composite restorations". Journal of Materials Chemistry B 8, n. 47 (2020): 10797–811. http://dx.doi.org/10.1039/d0tb02058c.

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Choi, Aerin, Kyung-Hyeon Yoo, Seog-Young Yoon, Bong-Soo Park, In-Ryoung Kim e Yong-Il Kim. "Anti-Microbial and Remineralizing Properties of Self-Adhesive Orthodontic Resin Containing Mesoporous Bioactive Glass". Materials 14, n. 13 (25 giugno 2021): 3550. http://dx.doi.org/10.3390/ma14133550.

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Self-adhesive resins (SARs) contain adhesives, which simplify the procedures of resin application, and primers, which provide sufficient bonding ability. In this study, mesoporous bioactive glass nanoparticles (MBN) were added to a SAR to easily improve the physical properties and remineralization ability. The experimental resins comprised 1%, 3%, and 5% MBN mixed in Ortho Connect Flow (GC Corp, Tokyo, Japan). As the MBN content in the SAR increased, the microhardness increased, and a statistically significant difference was observed between the cases of 1% and 5% MBN addition. Shear bond strength increased for 1% and 3% MBN samples and decreased for 5% MBN. The addition of MBN indicated a statistically significant antibacterial effect on both gram-negative and gram-positive bacteria. The anti-demineralization experiment showed that the remineralization length increased with the MBN content of the sample. Through the above results, we found that SAR containing MBN has antibacterial and remineralization effects. Thus, by adding MBN to the SAR, we investigated the possibility of orthodontic resin development, wherein the strength is enhanced and the drawbacks of the conventional SAR addressed.

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Kalinichenko, S., I. Torianyk e K. Melentyeva. "Obtaining of native microbial antigens with anti-adhesive properties". Reports of Vinnytsia National Medical University 26, n. 2 (14 giugno 2022): 175–78. http://dx.doi.org/10.31393/reports-vnmedical-2022-26(2)-01.

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Annotation. Traditional methods of sanitation of bacterial carriers of nosocomial infections of staphylococcal genesis using antibacterial drugs are ineffective and lead to the formation of antibiotic resistance in strains of microorganisms. Currently, when developing new classes of immunobiological drugs, it is recommended to use pathogen-associated molecular structures (PAMS) of bacteria that block surface epitopes and trigger the mechanisms of innate and adaptive immunity. The aim of the work was to obtain native surface antigens of Staphylococcus aureus using physical factors. Quantification of protein content in the obtained antigen preparations was performed using spectrophotometry according to the method of O. H. Lowry et al. (1951). The content of teichoic acids was determined according to the method of A. R. Archibald (2012). Adhesive properties were studied according to the method of V. I. Brilis et al. (1986). Each sample was tested in three to four replicates. Data were statistically processed using Statistica 8.0 (StatSoft Inc., USA) or Excel 2003, 2010 (Microsoft, USA). S. aureus surface antigens (Ag) were obtained as follows: a test culture of S. aureus ATСС 25923 was pre-irradiated with 61.0 GHz millimeter frequency range waves for eight hours, and then sonicated with a GZ-109 (60 kHz) or UZIN-2T (44 kHz) instrument and the protein and teichoic acid contents were measured. It was found that pretreatment of suspension S. aureus ATСС 25923 by 61.0 GHz millimeter frequency range waves increased the protein content in the samples by 1.5-1.9 times (p<0.01). Lipoteichoic acid content exceeded ribiteichoic acid content, on average, by 16.7 times (p<0.001) in samples obtained with the UZIN device and by 28.5 times (p<0.001) in samples obtained with the G3-10 device. All of the antigenic (Ag) samples obtained had anti-adhesive activity against S. aureus ATСС 25923, with the Ag5 sample (obtained using the GZ-109 instrument) exhibiting a more pronounced anti-adhesive activity. The use of physical factors will contribute to the standardization of the process of obtaining surface native structures and reduce the toxicity and reactogenicity of immunobiological preparations.

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Nam, Hyung-Jin, You-Min Kim, Yong Hoon Kwon, Kyung-Hyeon Yoo, Seog-Young Yoon, In-Ryoung Kim, Bong-Soo Park, Woo-Sung Son, Seung-Min Lee e Yong-Il Kim. "Fluorinated Bioactive Glass Nanoparticles: Enamel Demineralization Prevention and Antibacterial Effect of Orthodontic Bonding Resin". Materials 12, n. 11 (4 giugno 2019): 1813. http://dx.doi.org/10.3390/ma12111813.

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Orthodontic treatment involving the bonding of fixed appliances to tooth surfaces can cause white spot lesions (WSLs). WSLs increase the likelihood of cavity formation and hence require preservation and prosthetic restoration. Therefore, the prevention of WSLs is of greater importance than treatment. Application of fluoride or the use of fluoride-containing mouthwash can prevent WSLs, but this requires patient cooperation and additional time and cost. Bioactive glass containing 2.5% fluoride was synthesized and mixed with the orthodontic bonding adhesive Transbond XT Low Flow (LV) at ratios of 1, 3, and 5% to prepare orthodontic adhesive samples. Scanning electron microscopy (SEM) and X-ray diffraction (XRD) were used to characterize the samples. The Vickers hardness test, bracket retention test, and adhesive remnant index (ARI) of the samples were analysed to determine their mechanical properties. To determine the biological cytotoxicity, the cell activity of the samples was evaluated using cell viability tests and the antibacterial activity was analysed using Streptococcus mutans. To evaluate the anti-demineralization effect, the sample was bonded to extracted teeth and a pH cycle test was performed. Micro computed tomography data were obtained from the bonded teeth and sample, and the anti-demineralization effect was evaluated using the ImageJ software program. The Vickers hardness of the sample was higher than that of LV and was dependent on the concentration of fluoride-containing bioactive glass (FBAG). The bracket retention test and ARI of the sample showed no significant differences from those of LV. The cell viability test showed no significant changes at 24 and 48 h after application of the sample. The fluoride ion release test indicated an ion release rate of 9.5–17.4 μg/cm2. The antibacterial activity of the experimental group containing FBAG was significantly higher than that of the LV group. The anti-demineralization test showed a concentration-dependent increase. However, the resin containing 5 mass% FBAG (FBAG5) showed a statistically-significant increase compared with LV. The orthodontic adhesive containing FBAG showed antibacterial and anti-demineralization effects, thus indicating possible WSL prevention activity.

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Chen, Hui, Lisha Gu, Binyou Liao, Xuedong Zhou, Lei Cheng e Biao Ren. "Advances of Anti-Caries Nanomaterials". Molecules 25, n. 21 (30 ottobre 2020): 5047. http://dx.doi.org/10.3390/molecules25215047.

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Caries is the most common and extensive oral chronic disease. Due to the lack of anti-caries properties, traditional caries filling materials can easily cause secondary caries and lead to treatment failure. Nanomaterials can interfere with the bacteria metabolism, inhibit the formation of biofilm, reduce demineralization, and promote remineralization, which is expected to be an effective strategy for caries management. The nanotechnology in anti-caries materials, especially nano-adhesive and nano-composite resin, has developed fast in recent years. In this review, the antibacterial nanomaterials, remineralization nanomaterials, and nano-drug delivery systems are reviewed. We are aimed to provide a theoretical basis for the future development of anti-caries nanomaterials.

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Kreutz, Marietta, Christian Kreutz, Philipp Kanzow, Tobias T. Tauböck, Phoebe Burrer, Christine Noll, Oliver Bader, Bianca Rohland, Annette Wiegand e Marta Rizk. "Effect of Bioactive and Antimicrobial Nanoparticles on Properties and Applicability of Dental Adhesives". Nanomaterials 12, n. 21 (1 novembre 2022): 3862. http://dx.doi.org/10.3390/nano12213862.

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The aim of the study was to examine the applicability of bioactive and antibacterial nanoparticles to an experimental adhesive. The adhesive (60 wt% BisGMA, 15 wt% TEGDMA, 25 wt% HEMA) was mixed with combinations of 5 wt% methacryl-functionalized polyhedral oligomeric silsesquioxane (MA-POSS) and one kind of bioactive/antibacterial nanoparticles: 1 wt% core-shell silica-silver nanoparticle (SiO2@Ag), 1 wt% bioactive glass with bismuth (BAG-Bi) or 1 wt% calcium phosphate (CAP). Pure adhesive served as control. The physicochemical (degree of conversion (DC), linear shrinkage (LS), shear and complex viscosity, water sorption (WS), sol fraction (SF)), biological (antimicrobial effect) and bioactive (mineral precipitation) properties were investigated. DC and LS remained unchanged. The combination of BAG-Bi/MA-POSS resulted in a significantly increased WS and SF compared to control. In addition, the combination of CAP/MA-POSS slightly increased the shear viscosity of the adhesive. The addition of the nanoparticles did not influence the antimicrobial effects compared to the pure adhesive. Improved mineral inducing capacity could be detected in all nanoparticle combinations. The combination of bioactive and/or antibacterial nanoparticles showed improved mineral inducing capacity, but no antibacterial properties. The material properties were not or only slightly affected.

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Moreno-Vásquez, María J., Maribel Plascencia-Jatomea, Víctor M. Ocaño-Higuera, Francisco J. Castillo-Yáñez, Francisco Rodríguez-Félix, Ema C. Rosas-Burgos e Abril Z. Graciano-Verdugo. "Engineering and antibacterial properties of low-density polyethylene films with incorporated epigallocatechin gallate". Journal of Plastic Film & Sheeting 33, n. 4 (13 gennaio 2017): 413–37. http://dx.doi.org/10.1177/8756087916689382.

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The antibacterial activity of low-density polyethylene/adhesive resin (10%)/epigallocatechin gallate (0.03, 0.5, 5, and 10%) extrusion cast films were evaluated against Staphylococcus aureus (gram positive) and Pseudomonas sp. (gram negative) via direct contact and in solid and liquid culture media. The epigallocatechin gallate concentration in the active films was established per the in vitro antibacterial analysis of pure epigallocatechin gallate against S. aureus and Pseudomonas sp. The epigallocatechin gallate migration profile and concentration required to inhibit bacterial growth in broth were determined. In addition, the effects of epigallocatechin gallate and adhesive resin on the mechanical, color, and thermal film properties were investigated. The results indicate that pure epigallocatechin gallate inhibited the growth of both bacteria. However, only the films with 10 wt% epigallocatechin gallate (with and without adhesive resin) induced morphological changes and inhibited the growth of S. aureus (p < 0.05). In addition, the films with 10 wt% epigallocatechin gallate (with adhesive resin) induced morphological changes in Pseudomonas sp. (p < 0.05). The adhesive resin increased the epigallocatechin gallate release rate in the migration profile (p < 0.05). The epigallocatechin gallate and adhesive resin modified the film properties (p < 0.05). Fourier transform infrared analysis indicated hydrogen bonds between the adhesive resin and epigallocatechin gallate. This study demonstrated that epigallocatechin gallate is a potential antibacterial agent and that adhesive resin provides advantages to active films.

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Xu, Zhengwei, Tingting Wang e Junqiu Liu. "Recent Development of Polydopamine Anti-Bacterial Nanomaterials". International Journal of Molecular Sciences 23, n. 13 (30 giugno 2022): 7278. http://dx.doi.org/10.3390/ijms23137278.

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Polydopamine (PDA), as a mussel-inspired material, exhibits numerous favorable performance characteristics, such as a simple preparation process, prominent photothermal transfer efficiency, excellent biocompatibility, outstanding drug binding ability, and strong adhesive properties, showing great potential in the biomedical field. The rapid development of this field in the past few years has engendered substantial progress in PDA antibacterial materials. This review presents recent advances in PDA-based antimicrobial materials, including the preparation methods and antibacterial mechanisms of free-standing PDA materials and PDA-based composite materials. Furthermore, the urgent challenges and future research opportunities for PDA antibacterial materials are discussed.

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Kara, Filiz, Eda Ayse Aksoy, Semih Calamak, Nesrin Hasirci e Serpil Aksoy. "Immobilization of heparin on chitosan-grafted polyurethane films to enhance anti-adhesive and antibacterial properties". Journal of Bioactive and Compatible Polymers 31, n. 1 (2 settembre 2015): 72–90. http://dx.doi.org/10.1177/0883911515598794.

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Moura, M. C., D. S. Trentin, T. H. Napoleão, M. Primon-Barros, A. S. Xavier, N. P. Carneiro, P. M. G. Paiva, A. J. Macedo e L. C. B. B. Coelho. "Multi-effect of the water-solubleMoringa oleiferalectin againstSerratia marcescensandBacillussp.: antibacterial, antibiofilm and anti-adhesive properties". Journal of Applied Microbiology 123, n. 4 (11 settembre 2017): 861–74. http://dx.doi.org/10.1111/jam.13556.

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Feuerstein, Osnat, Shlomo Matalon, Hagay Slutzky e Ervin I. Weiss. "Antibacterial properties of self-etching dental adhesive systems". Journal of the American Dental Association 138, n. 3 (marzo 2007): 349–54. http://dx.doi.org/10.14219/jada.archive.2007.0167.

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Jia, Ao, Pei Wang, Fei Tong, Ziqiang Chen, Yunyun Deng, Haiyan Yao, Lianguo Wang, Yifan Liu e Hongshan Ge. "Developing a Novel Enamel Adhesive with Amorphous Calcium Phosphate and Silver Nanoparticles to Prevent Demineralization during Orthodontic Treatment". Journal of Functional Biomaterials 14, n. 2 (29 gennaio 2023): 77. http://dx.doi.org/10.3390/jfb14020077.

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Abstract (sommario):

During fixed orthodontic treatment, white spot lesions are prevalent issues associated with cariogenic bacteria. This study aims to construct an orthodontic adhesive containing nanoparticles of amorphous calcium phosphate-polydopamine-Ag (NPA) fillers to combat white spot lesions. The NPA fillers were prepared and characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and X-ray photoelectron spectroscopy (XPS). The biocompatibility of the fillers was evaluated. A colony counting test evaluated the antibacterial property of the fillers against Streptococcus mutans (S. mutans). NPA fillers were mixed with orthodontic adhesive (Transbond XT) at different weight ratios (0, 0.1, 0.2, 0.3, and 0.5 wt.%). The shear bond strength and antibacterial properties were then further investigated. The results showed that NPA was prepared successfully, with good antibacterial properties. The cell survival rate of all groups of fillers was higher than 70%, showing good biocompatibility. Moreover, the shear bond strength of the orthodontic adhesive with 0.2 wt.% NPA fillers was 11.89 ± 1.27 MPa, meeting the minimal clinical bond strength requirements of 7.8 MPa. Furthermore, the orthodontic adhesive resin blocks and the extract displayed good antibacterial properties, with the number of colonies decreasing significantly (p < 0.001). Taken together, we think that an orthodontic adhesive with NPA may have a good application potential for the prevention and treatment of white spot lesions.

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Piras, Anna Maria, Semih Esin, Arianna Benedetti, Giuseppantonio Maisetta, Angela Fabiano, Ylenia Zambito e Giovanna Batoni. "Antibacterial, Antibiofilm, and Antiadhesive Properties of Different Quaternized Chitosan Derivatives". International Journal of Molecular Sciences 20, n. 24 (13 dicembre 2019): 6297. http://dx.doi.org/10.3390/ijms20246297.

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In the era of antimicrobial resistance, the identification of new antimicrobials is a research priority at the global level. In this regard, the attention towards functional antimicrobial polymers, with biomedical/pharmaceutical grade, and exerting anti-infective properties has recently grown. The aim of this study was to evaluate the antibacterial, antibiofilm, and antiadhesive properties of a number of quaternized chitosan derivatives that have displayed significant muco-adhesive properties and wound healing promotion features in previous studies. Low (QAL) and high (QAH) molecular weight quaternized chitosan derivatives were synthetized and further modified with thiol moieties or pendant cyclodextrin, and their antibacterial activity evaluated as minimal inhibitory concentrations (MIC) and minimal bactericidal concentrations (MBC). The ability of the derivatives to prevent biofilm formation was assessed by crystal violet staining. Both QAL and QAH derivatives exerted a bactericidal and/or inhibitory activity on the growth of P. aeruginosa and S. epidermidis. The same compounds also showed marked dose-dependent anti-biofilm activity. Furthermore, the high molecular weight derivative (QAH) was used to functionalize titanium plates. The successful functionalization, demonstrated by electron microscopy, was able to partially inhibit the adhesion of S. epidermidis at 6 h of incubation. The shown ability of the chitosan derivatives tested to both inhibit bacterial growth and/or biofilm formation of clinically relevant bacterial species reveals their potential as multifunctional molecules against bacterial infections.

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Yin, Yi, Qianqian Xu, Xin Wei, Qianyun Ma, Dongsheng Li e Juanjuan Zhao. "Rosmarinic Acid-Grafted Dextran/Gelatin Hydrogel as a Wound Dressing with Improved Properties: Strong Tissue Adhesion, Antibacterial, Antioxidant and Anti-Inflammatory". Molecules 28, n. 10 (11 maggio 2023): 4034. http://dx.doi.org/10.3390/molecules28104034.

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Designing a strong tissue adhesive and multifunctional hydrogel dressing for various skin injuries is still a significant challenge. Based on the bioactive activities of rosmarinic acid (RA) and its catechol structure being similar to dopamine, RA-grafted dextran/gelatin hydrogel (ODex−AG−RA) was designed and systemically characterized in this study. The ODex−AG−RA hydrogel exhibited excellent physicochemical properties, including fast gelation time (61.6 ± 2.8 s), strong adhesive strength (27.30 ± 2.02 kPa) and enhanced mechanical properties (1.31 × 104 Pa of G′). The examination of hemolysis and co-culturing with L929 cells showed the strong in vitro biocompatibility of ODex−AG−RA hydrogels. The ODex−AG−RA hydrogels exhibited a 100% mortality rate against S. aureus and at least 89.7% against E. coli in vitro. In vivo evaluation for efficacy in skin wound healing was carried out in a rat model of full-thickness skindefect. The amount of collagen deposition and CD31 on wounds in the two ODex−AG−RA−1 groups on day 14 was 4.3 times and 2.3 times of that in the control group, respectively. Furthermore, the mechanism of ODex−AG−RA−1 for promoting wound healing was proved to be related to its anti-inflammatory properties by adjusting the expression of inflammatory cytokines (TNF-α and CD163) and reducing the level of oxidative stress (MDA and H2O2). Overall, this study demonstrated the wound-healing efficacy of RA-grafted hydrogels for the first time. ODex−AG−RA−1 hydrogel, due to its adhesive, anti-inflammatory, antibacterial and antioxidative activities, was a promising candidate as a wound dressing.

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Solanki, Jyoti, Dhaval Patel e M. Nataraj. "Exploring the Potential of Dyadobacter fermentans JDP9 Biosurfactants an Antibacterial and Antifouling Biocompatible Agent". Journal of Advanced Scientific Research 15, n. 11 (7 dicembre 2024): 01–09. https://doi.org/10.55218/jasr.2024151101.

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Abstract (sommario):

This study investigated the antibacterial and antiadhesive properties of a biosurfactant (BS) produced by Dyadobacter fermentans JDP9 against various Gram-positive and Gram-negative bacteria. The presence of BS was confirmed using oil spreading test, drop collapsing test and emulsification test. The BS demonstrated antimicrobial effects against Bacillus subtilis, Enterobacter aerogenes, Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus faecalis at a 500 mg/mL concentration. Using a 96-well microtiter plate, the results indicated that both antibacterial and antiadhesive activities increased with higher BS concentrations. Glass slides coated with BS showed significantly reduced biofilm formation compared to control slides. The BS inhibited 71% of P. aeruginosa biofilm formation on a medical-grade catheter. Vero cells treated with BS exhibited moderate morphological changes with an IC50 value of 217.5 μg/mL, indicating biocompatibility at 200 μg/mL. These findings suggest that BS, with its antibacterial, anti-adhesive, and biocompatible properties, holds potential as a biodegradable antifouling agent.

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Twomley, Jefferson, Yapin Wang, Zezhang Wen, Qingzhao Yu, Richard Ballard, Paul Armbruster e Xiaoming Xu. "Formulation and characterization of antibacterial orthodontic adhesive". Dental Press Journal of Orthodontics 24, n. 4 (agosto 2019): 73–79. http://dx.doi.org/10.1590/2177-6709.24.4.073-079.oar.

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Abstract (sommario):

ABSTRACT Objective: The objective of this study was to formulate experimental orthodontic bracket adhesives and test their mechanical properties, fluoride release and antibacterial activity. Methods: Four experimental antibacterial orthodontic bracket adhesives were prepared with different compositions of synthesized antibacterial monomers replacing total 5% of dental monomers in the control Transbond XT (3M): 5%C11, 3.5%C11+1.5%C2, 5%C16, and 3.5%C16+1.5%C2. Transbond XT alone was used as control. These groups were used to bond premolar brackets to extracted premolars. Shear bond strength (SBS) was tested using an Instron machine. For antibacterial test, disk specimens (10mm diameter, 1mm thick, n=4) were fabricated and incubated with cultures of cariogenic Streptococcus mutans for 48h, and following gentle sonication, S. mutans biofilms in colony-forming-units (CFU) on the disks were enumerated by plating on agar medium. The data were analyzed using ANOVA and Tukey test (α=0.05). Results: All experimental groups had similar shear bond strength (no significant difference) to the control. All experimental groups showed significant inhibitory effect against S. mutans biofilm formation, when compared to the control, but there was no significant difference between experimental groups. Conclusion: Antibacterial orthodontic adhesive can be fabricated to have similar mechanical properties but better caries-inhibitory effect than current adhesive.

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Lee, Seung-Min, Kyung-Hyeon Yoo, Seog-Young Yoon, In-Ryoung Kim, Bong-Soo Park, Woo-Sung Son, Ching-Chang Ko, Sung-Ae Son e Yong-Il Kim. "Enamel Anti-Demineralization Effect of Orthodontic Adhesive Containing Bioactive Glass and Graphene Oxide: An In-Vitro Study". Materials 11, n. 9 (14 settembre 2018): 1728. http://dx.doi.org/10.3390/ma11091728.

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Abstract (sommario):

White spot lesions (WSLs), a side effect of orthodontic treatment, can result in reversible and unaesthetic results. Graphene oxide (GO) with a bioactive glass (BAG) mixture (BAG@GO) was added to Low-Viscosity Transbond XT (LV) in a ratio of 1, 3, and 5%. The composite’s characterization and its physical and biological properties were verified with scanning electron microscopy (SEM) and X-ray diffraction (XRD); its microhardness, shear bond strength (SBS), cell viability, and adhesive remnant index (ARI) were also assessed. Efficiency in reducing WSL was evaluated using antibacterial activity of S. mutans. Anti-demineralization was analyzed using a cycle of the acid-base solution. Adhesives with 3 wt.% or 5 wt.% of BAG@GO showed significant increase in microhardness compared with LV. The sample and LV groups showed no significant differences in SBS or ARI. The cell viability test confirmed that none of the sample groups showed higher toxicity compared to the LV group. Antibacterial activity was higher in the 48-h group than in the 24 h group; the 48 h test showed that BAG@GO had a high antibacterial effect, which was more pronounced in 5 wt.% of BAG@GO. Anti-demineralization effect was higher in the BAG@GO-group than in the LV-group; the higher the BAG@GO concentration, the higher the anti-demineralization effect.

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25

Yang, Jing Quan, Zheng Wang, Jin Hui Wu, Li Mei Hao, Tao Tian e Song Lin. "Study on an Air Filter Material Immobilized with Bio-Antimicrobials". Advanced Materials Research 152-153 (ottobre 2010): 1519–24. http://dx.doi.org/10.4028/www.scientific.net/amr.152-153.1519.

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Abstract (sommario):

Use of an air filter material combined with antibacterial agents is one of the most effective methods to resolve the problem of air filter contaminated by pathogenic microbes. ε-Polylysine and Natamycin are two biogenic antimicrobials that have been widely applied in recent years because of their high antibacterial efficiency, harmlessness to human body and environmental friendliness. In this paper, a novel antibacterial air filter material was prepared by immobilizing ε-Polylysine and Natamycin onto fiberglass high efficiency air filter media by acrylate adhesive bonding. The mechanical properties, aerosol filtration properties, and antibacterial properties were then evaluated. An improvement in the mechanical properties of the material prepared was seen compared to the untreated filter media. The filtration efficiency of the material prepared for particle aerosols and bioaerosols both greater than 99.997%. Antibacterial efficiency of the material prepared against Staphylococcus aureus and Escherichia coli in suspensions were both greater than 99.99% compared to the untreated filter media. The anti-mildew effect against Aspergillus niger in suspension was strong compared to the untreated filter media. Antibacterial efficiency of the material prepared against bacteria in bioaerosols was greater than 99.99%. Observed with Scanning Electron Microscope, most bacteria on antibacterial filter media appeared to be dead. Thus, antibacterial air filter material prepared by immobilizing bio-antimicrobials on fiberglass had a strong inhibitory effect against gram-positive bacteria, gram-negative bacteria and fungi, with no impairment of the intrinsic properties. This kind of material appears to be promising for application in air cleaning and biological protection fields.

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26

Yang, Yubin, Jingyu Ding, Xuanyan Zhu, Zilu Tian e Song Zhu. "Triclosan to Improve the Antimicrobial Performance of Universal Adhesives". Polymers 15, n. 2 (6 gennaio 2023): 304. http://dx.doi.org/10.3390/polym15020304.

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Abstract (sommario):

To solve the proble ms of composite restoration failure caused by secondary caries, this study reports a light curable antibacterial triclosan derivative (TCS-IH), which was synthesized and added to the existing commercial universal adhesive to achieve a long-term antibacterial effect The effect of mixing different mass percentages of TCS-IH on the bond strength of dentin was also investigated.TCS-IH was synthesized by solution polymerization and characterized by nuclear magnetic resonance hydrogen spectroscopy (1H NMR) and Fourier transform infrared (FTIR) spectroscopy. Two commercial universal adhesives, Single Bond Universal and All Bond Universal, were selected and used as the control group, and universal adhesives with different mass percentages (1 wt%, 3 wt%, 5 wt% and 7 wt%) of TCS-IH were used as the experimental group. The antibacterial properties were analysed by means of colony count experiments, biofilm formation detection, plotting of growth curves, biofilm metabolic activity detection, insoluble extracellular polysaccharide measurements and observations by confocal laser scanning microscopy and scanning electron microscopy (SEM). The effect of adhesives on biofilm formation, metabolism, extracellular matrix production, distribution of live and dead bacteria, and bacterial morphology of Streptococcus mutans (S. mutans) was analysed. The mechanical properties were evaluated by the degree of conversion and microtensile bonding strength under different conditions. Its biosafety was tested. We found that the addition of TCS-IH significantly improved the antibacterial performance of the universal adhesive, with the 5 wt% and 7 wt% groups showing the best antibacterial effect and effectively inhibiting the formation of biofilm. In addition, the adhesive strength test results showed that there was no statistical difference (p < 0.05) in the microtensile bond strength measured under various factors in all experimental groups except for the 7 wt% group in the self-etch bonding mode, and all of them had good biosafety. In summary, the 5 wt% group of antibacterial monomer TCS-IH was selected as the optimum addition to the universal adhesive to ensure the antimicrobial properties of the universal adhesive and the stability and durability of the adhesive interface. This study provides a reference for the clinical application of adhesives with antimicrobial activity to improve the stability and durability of adhesive restorations.

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Donnier-Maréchal, Marion, Nicolas Galanos, Teddy Grandjean, Yoann Pascal, Ding-Kun Ji, Lei Dong, Emilie Gillon et al. "Perylenediimide-based glycoclusters as high affinity ligands of bacterial lectins: synthesis, binding studies and anti-adhesive properties". Organic & Biomolecular Chemistry 15, n. 47 (2017): 10037–43. http://dx.doi.org/10.1039/c7ob02749d.

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28

Kefallinou, Dionysia, Kosmas Ellinas, Thanassis Speliotis, Kostas Stamatakis, Evangelos Gogolides e Angeliki Tserepi. "Optimization of Antibacterial Properties of “Hybrid” Metal-Sputtered Superhydrophobic Surfaces". Coatings 10, n. 1 (30 dicembre 2019): 25. http://dx.doi.org/10.3390/coatings10010025.

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Abstract (sommario):

Bacterial attachment and colonization to hygiene sensitive surfaces, both public and nosocomial, as well as in food industry areas, poses a serious problem to human healthcare. Several infection incidents are reported, while bacterial resistance to antibiotics is increasing. Recently, novel techniques for the design of antibacterial surfaces to limit bacterial spreading have emerged, including bifunctional antibacterial surfaces with antifouling and bactericidal action. In this context, we have recently developed smart, universal, metal-sputtered superhydrophobic surfaces, demonstrating both bacterial repulsion and killing efficacy. Herein, we present the optimization process that led to the realization of these “hybrid” antibacterial surfaces. To this end, two bactericidal agents, silver and copper, were tested for their efficiency against Gram-negative bacteria, with copper showing a stronger bactericidal action. In addition, between two low surface energy coatings, the fluorinated-alkyl self-assembled chlorosilane layer from perfluorinated octyltrichlorosilane (pFOTS) solution and the fluorocarbon layer from octafluorocyclobutane (C4F8) plasma were both approved for their anti-adhesive properties after immersion in bacterial solution. However, the latter was found to be more efficient when engrafted with the bactericidal agent in shielding its killing performance. Furthermore, the thickness of the plasma-deposited fluorocarbon layer was optimized, in order to simultaneously retain both the superhydrophobicity of the surface and its long-term bactericidal activity.

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Lopes, Stephanie R., Amanda G. N. Matuda, Raquel P. Campos, Ana Paula V. P. Mafetano, Ana Helena M. Barnabe, Gabriela S. Chagas, Daphne C. Barcellos, Li-Na Niu, Franklin R. Tay e Cesar R. Pucci. "Development of an Antibacterial Dentin Adhesive". Polymers 14, n. 12 (19 giugno 2022): 2502. http://dx.doi.org/10.3390/polym14122502.

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Abstract (sommario):

Nisin is a peptide that possesses potent antibacterial properties. This study evaluated the antibacterial activity of a nisin-doped adhesive against Streptococcus mutans, as well as its degree of conversion and microtensile bond strength (μTBS) to dentin. Nisin was added to the adhesive Adper Single Bond 2 (3M ESPE), resulting in four groups: Control Group (Single Bond 2); Group 1% (1 wt% nisin-incorporated), Group 3% (3 wt% nisin-incorporated) and Group 5% (5 wt% nisin-incorporated). Antibacterial activity against S. mutans was evaluated using colony-forming unit counts (CFU). The degree of conversion was tested using FTIR. Forty human teeth were restored for μTBS evaluation. Data were statistically analyzed with ANOVA and Tukey tests at α = 0.05. The nisin-doped adhesives, for all concentrations, exhibited a significant inhibition of the growth of S. mutans (p < 0.05); Incorporation of 5% and 3% nisin decreased the degree of conversion of the adhesive (p < 0.05). The μTBS (in MPa): Control Group—38.3 ± 2.3A, Group 1%—35.6 ± 2.1A, Group 3%—27.1 ± 1.6B and Group 5%—22.3 ± 1.0C. Nisin-doped adhesives exerted a bactericidal effect on S. mutans. The μTBS and degree of conversion of adhesive were not affected after incorporation of 1% nisin.

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30

Huang, Tao, Jin Zhang, Ming Fu Li, Wen Wei Lian, Jun Yan He, Zhi Kai Zhuang, Zheng Peng e Xiao Yu Liu. "Adhesive Content Influence on Antimicrobial Properties of Pineapple Leaf Fiber". Advanced Materials Research 1048 (ottobre 2014): 3–8. http://dx.doi.org/10.4028/www.scientific.net/amr.1048.3.

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Abstract (sommario):

This study tests the antimicrobial properties of pineapple leaf fiber. Scanning electron microscopy (SEM), infrared analysis (IR) and other test methods were used to examine the microcosmic morphologies of pineapple leaf fiber. As the pineapple leaf fiber adhesive content reduce fiber antibacterial. Adhesive content 54% of fiber to escherichia coli and staphylococcus aureus antibacterial value is maximum. With further reduce fiber adhesive content, fiber antimicrobial declined obviously. The results indicate that the anaerobic bacteria can’t survive in the inside of pineapple leaf fiber where exist a large specific surface-area, lots of holes and Voids, and much oxygen. Pineapple leaf fiber contains a lot of phenols and their derivatives which are effective natural bacteria resistant materials and inhibit the metabolism and physiology of bacillus and other microorganism,break the structure of germ, and repress the generation of bacillus until the death of germ.Moreover, the existence of a small amount of cannabinol is adequate to kill the microorganisms.

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Teri, Gele, Cong Cheng, Kezhu Han, Dan Huang, Jing Li, Yujia Luo, Peng Fu e Yuhu Li. "Study on the Properties of FEVE Modified with Ag2O/OH-MWCNTS Nanocomposites for Use as Adhesives for Wooden Heritage Objects". Molecules 29, n. 6 (19 marzo 2024): 1365. http://dx.doi.org/10.3390/molecules29061365.

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Abstract (sommario):

The durability of wooden heritage objects and sites can be affected by external environmental factors, leading to decay, cracking, and other forms of deterioration, which might ultimately result in significant and irreversible loss. In this study, a FEVE resin was modified with Ag2O/OH-MWCNTS (MA), denoted as MAF, where three concentrations were prepared using in situ precipitation, and the resulting composite adhesive was characterized by a high viscosity and effective bacteriostatic properties, demonstrating a better viscosity and thermal stability, as well as antibacterial properties, than pure FEVE resin. The results show that MAF adhesives present good thermal stability, as evidenced by a lower mass loss rate following treatment at 800 °C compared to the pure FEVE resin. At a consistent shear rate, the viscosity of MAF demonstrates a notable increase with the proportion of MA, which is better than that of FEVE. This suggests that the nano-Ag2O particles in MA act as physical crosslinking agents in FEVE, improving the viscosity of the composite adhesive MAF. The adhesion strength between MAF and wood exhibits a similar trend, with wooden samples showing higher shear strengths as the proportion of MA increases in comparison to FEVE. Simultaneously, the antibacterial effects of the MAF adhesive exceeded 1 mm for Trichoderma, Aspergillus niger, and white rot fungi. The antibacterial activity of the MAF adhesive exhibited a direct correlation with the concentration of Ag2O/OH-MWCNTS, with the most pronounced inhibitory effect observed on Trichoderma. The MAF adhesive demonstrates promising prospects as an adhesive for wooden heritage artifacts, offering a novel approach for the rapid, environmentally friendly, and efficient development of composite adhesives with superior adhesive properties.

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32

N/A. "Triclosan: Antibacterial and Anti-inflammatory Properties". Biological Therapies in Dentistry 20, n. 04 (2004): 13. http://dx.doi.org/10.2310/7040.2004.20412.

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33

Carvalho, A. L., A. C. Vale, M. P. Sousa, A. M. Barbosa, E. Torrado, J. F. Mano e N. M. Alves. "Antibacterial bioadhesive layer-by-layer coatings for orthopedic applications". Journal of Materials Chemistry B 4, n. 32 (2016): 5385–93. http://dx.doi.org/10.1039/c6tb00841k.

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Abstract (sommario):

In this study, thin LbL films were produced by combining the adhesive properties of the hyaluronic acid–dopamine conjugate with the bioactivity and bactericidal properties of silver doped bioactive glass nanoparticles.

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34

Anvari, Sanam, Hamidreza Hajfarajollah, Babak Mokhtarani, Mobin Enayati, Ali Sharifi e Mojtaba Mirzaei. "Antibacterial and anti-adhesive properties of ionic liquids with various cationic and anionic heads toward pathogenic bacteria". Journal of Molecular Liquids 221 (settembre 2016): 685–90. http://dx.doi.org/10.1016/j.molliq.2016.05.093.

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35

Gou, Ya-ping, Mohamed M. Meghil, Cesar R. Pucci, Lorenzo Breschi, David H. Pashley, Christopher W. Cutler, Li-na Niu, Ji-yao Li e Franklin R. Tay. "Optimizing resin-dentin bond stability using a bioactive adhesive with concomitant antibacterial properties and anti-proteolytic activities". Acta Biomaterialia 75 (luglio 2018): 171–82. http://dx.doi.org/10.1016/j.actbio.2018.06.008.

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36

Akarajarasrod, Pinyada, Surachai Dechkunakorn, Pornpen Tantivitayakul, Primana Punnakitikashem, Wassana Wichai, Phetladda Pannak Whitis e Niwat Anuwongnukroh. "Antibacterial Effect of Experimental Orthodontic Adhesives Containing Gold Nanoparticles against <i>Streptococcus mutans</i> and <i>Streptococcus sobrinus</i>". Key Engineering Materials 904 (22 novembre 2021): 301–8. http://dx.doi.org/10.4028/www.scientific.net/kem.904.301.

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Abstract (sommario):

Enamel decalcification usually can be found around orthodontic bracket after debonding. Orthodontic adhesives resistant to bacterial colonization were used to prevent white spot lesion and dental caries in orthodontic treatment with fixed appliance. The objectives of this study were to evaluate the antibacterial properties of expeimental orthodontic adhesive containing gold nanoparticles (AuNPs). 108 orthodontic adhesive discs containing 1.0 wt%, 0.5 wt%, 0.25 wt% AuNPs and without AuNPs were prepared from in-house orthodontic adhesive (27 discs per group). The antibcterial properties of adhesive discs were evaluated by direct contact test. Streptococcus mutans and Streptococcus sobrinus suspensions were placed on the discs and incubated at 37 °C for 1 hour. The adhesive discs were transferred to BHI broth and were incubated at 37°C for 16, 20 and 24 h. Bacterial growth was evaluated by optical density (OD) measurement at 590nm. The results showed that experimental orthodontic adhesives with 1.0 wt% and 0.5 wt% AuNPs exhibited higher antibacterial activity compared to the control group (p < 0.05). At 24 h of incubation, the median OD of 1.0 wt%, 0.5 wt%, 0.25 wt% and control in S. mutans were 0.109, 0.006, 0.007 and 0.372, rescpectively. In S. sobrinus, the median OD were 0.173, 0.012 , 0.007 and 0.328. The incorporation of gold nanoparticles into orthodontic adhesives exhibited antibacterial activity against cariogenic microorganism. At a concentration of 0.5 wt% and 1.0 wt% AuNPs, experimental orthodontic adhesive could reduce bacterial growth of both S. mutans and S. sobrinus.

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Shu, Qin, Hanghang Lou, Tianyu Wei, Xiayu Liu e Qihe Chen. "Contributions of Glycolipid Biosurfactants and Glycolipid-Modified Materials to Antimicrobial Strategy: A Review". Pharmaceutics 13, n. 2 (6 febbraio 2021): 227. http://dx.doi.org/10.3390/pharmaceutics13020227.

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Abstract (sommario):

Glycolipid biosurfactants are natural amphiphiles and have gained particular interest recently in their biodegradability, diversity, and bioactivity. Microbial infection has caused severe morbidity and mortality and threatened public health security worldwide. Glycolipids have played an important role in combating many diseases as therapeutic agents depending on the self-assembly property, the anticancer and anti-inflammatory properties, and the antimicrobial properties, including antibacterial, antifungal, and antiviral effects. Besides, their role has been highlighted as scavengers in impeding the biofilm formation and rupturing mature biofilm, indicating their utility as suitable anti-adhesive coating agents for medical insertional materials leading to a reduction in vast hospital infections. Notably, glycolipids have been widely applied to the synthesis of novel antimicrobial materials due to their excellent amphipathicity, such as nanoparticles and liposomes. Accordingly, this review will provide various antimicrobial applications of glycolipids as functional ingredients in medical therapy.

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38

Wang, Qinhua, Hui Zhang, Xiaofeng Pan, Xiaojuan Ma, Shilin Cao e Yonghao Ni. "Adhesive, Transparent Tannic Acid@ Sulfonated Lignin-PAM Ionic Conductive Hydrogel Electrode with Anti-UV, Antibacterial and Mild Antioxidant Function". Materials 12, n. 24 (10 dicembre 2019): 4135. http://dx.doi.org/10.3390/ma12244135.

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Abstract (sommario):

Inspired by mussel adhesion chemistry and ion electronics, a novel Ca2+-tannic acid@ sulfonated lignin-polyacrylamide (TA@SL-PAM) hydrogel was prepared via Ca2+-TA@SL composites and the PAM system, where a Ca2+-TA@SL composite was fabricated via TA doping with SL and the subsequent adsorption of Ca2+. The properties of the hydrogel were thoroughly investigated and the hydrogel was presented as multifunctional. The introduction of Ca2+-TA@SL composites endowed the hydrogel with excellent conductivity, adhesion and ultraviolet (UV) resistance, and improved antioxidant and antibacterial properties. More importantly, the Ca2+-TA@SL-PAM hydrogel electrode could accurately detect physiological signals of human (e.g., electrocardiogram (ECG), electromyography (EMG).

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39

Restivo, Elisa, Emanuela Peluso, Nora Bloise, Giovanni Lo Bello, Giovanna Bruni, Marialaura Giannaccari, Roberto Raiteri, Lorenzo Fassina e Livia Visai. "Surface Properties of a Biocompatible Thermoplastic Polyurethane and Its Anti-Adhesive Effect against E. coli and S. aureus". Journal of Functional Biomaterials 15, n. 1 (15 gennaio 2024): 24. http://dx.doi.org/10.3390/jfb15010024.

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Abstract (sommario):

Thermoplastic polyurethane (TPU) is a polymer used in a variety of fields, including medical applications. Here, we aimed to verify if the brush and bar coater deposition techniques did not alter TPU properties. The topography of the TPU-modified surfaces was studied via AFM demonstrating no significant differences between brush and bar coater-modified surfaces, compared to the un-modified TPU (TPU Film). The effect of the surfaces on planktonic bacteria, evaluated by MTT assay, demonstrated their anti-adhesive effect on E. coli, while the bar coater significantly reduced staphylococcal planktonic adhesion and both bacterial biofilms compared to other samples. Interestingly, Pearson’s R coefficient analysis showed that Ra roughness and Haralick’s correlation feature were trend predictors for planktonic bacterial cells adhesion. The surface adhesion property was evaluated against NIH-3T3 murine fibroblasts by MTT and against human fibrinogen and human platelet-rich plasma by ELISA and LDH assay, respectively. An indirect cytotoxicity experiment against NIH-3T3 confirmed the biocompatibility of the TPUs. Overall, the results indicated that the deposition techniques did not alter the antibacterial and anti-adhesive surface properties of modified TPU compared to un-modified TPU, nor its bio- and hemocompatibility, confirming the suitability of TPU brush and bar coater films in the biomedical and pharmaceutical fields.

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Oh, Seung Jun, Won Sik Han e Koang Chul Wi. "A Study on the Manufacture and Physical Properties of Liquid Adhesive for Wood Preservation - Focusing on the Synthesis of Gelatin and Carrageenan -". Journal of Conservation Science 37, n. 6 (31 dicembre 2021): 801–6. http://dx.doi.org/10.12654/jcs.2021.37.6.17.

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Abstract (sommario):

In order to improve the usability of glue, a traditional adhesive material, and the gelation process of seaweed extract carrageenan, a liquid adhesive for wood preservation was prepared by mixing the two materials. The prepared wood adhesive was mixed with a 15 wt% aqueous solution of glue, λ-carrageenan, an antibacterial agent, an antifoaming agent, and the maximum adhesive strength of 1.80 Mpa was confirmed. As a result of comparison, the adhesive strength was superior to that of 5 different types of traditional natural adhesive ingredients (aqueous solution) and 1 type of polyvinyl acetate-based adhesive.

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41

Hou, Yi, Ying Song, Xiaodong Sun, Yulin Jiang, Meiling He, Yubao Li, Xianchun Chen e Li Zhang. "Multifunctional composite hydrogel bolus with combined self-healing, antibacterial and adhesive functions for radiotherapy". Journal of Materials Chemistry B 8, n. 13 (2020): 2627–35. http://dx.doi.org/10.1039/c9tb02967b.

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42

Nimittrakoolchai, O., e Sitthisuntorn Supothina. "Nanocrystalline TiO₂ Coated-Fabric for UV Shielding and Anti-Bacterial Functions". Materials Science Forum 569 (gennaio 2008): 21–24. http://dx.doi.org/10.4028/www.scientific.net/msf.569.21.

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Abstract (sommario):

Due to excellent photocatalytic and optical properties of titanium dioxide (TiO2), it has been applied in several products such as food packaging plastics, materials for vehicles or for buildings and sunscreen-protecting cosmetics. In this present work, the synthesized as well as commercial TiO2 was coated onto a household curtain fabric for anti-microbial and ultraviolet (UV) shielding functions. The coating was performed by inducing the deposition of TiO2 layer from the Ti precursor onto the fabric surface pre-treated with silane adhesive agent so as to improve the adhesion. Ag nanoparticles were also incorporated in some samples to further improve the antibacterial function. Anti-bacterial activities of the coated fabric were evaluated by standard qualitative test (the Kirby-Bauer test (AATCC 147)). Efficiency for UV shielding was evaluated by measuring a UV-Vis reflection of the coated fabrics both before and after subjecting to several washing cycles. The result showed that the TiO2-coated fabrics developed had potential as antibacterial and UV shielding for the curtain industry.

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Afzal, Aqsa, Syed Nisar Hussain Shah, Hina Javed, Asma Mumtaz, Javeria Saeed, Hafiz Majid Rasheed, Rabia Arshad, Siddique Akber Ansari, Hamad M. Alkahtani e Irfan Aamer Ansari. "Spilanthes acmella Extract-Based Natural Oils Loaded Emulgel for Anti-Microbial Action against Dermatitis". Gels 9, n. 10 (20 ottobre 2023): 832. http://dx.doi.org/10.3390/gels9100832.

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Abstract (sommario):

Background: Dermatitis is skin disorder that is complicated by recurrent infections of skin by bacteria, viruses, and fungi. Spilanthol is an active constituent of Spilanthes acmella, which possess strong anti-bacterial properties. The purpose of this study was to develop a herbal emulgel for the treatment of dermal bacterial infections, as microscopic organisms have created solid resistance against anti-microbials. Methods: Emulgels were prepared and characterized for parameters such as physical examination, rheological studies, spreading coefficient, bio-adhesive strength measurement, extrudability study, antibacterial activity, FTIR analysis, in vitro drug dissolution, and ex vivo permeation studies. Result: With a statistically significant p-value = 0.024, 100% antibacterial activity was observed by F4 against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli (mean ± S.D) (25.33 ± 0.28, 27.33 ± 0.5, and 27 ± 0.5). However, maximum antibacterial effect 100% formulations produced zones of inhibitions against E. colip-value = 0.001. The mean zone of inhibition produced by F4 was greatest among all at 26.44 ± 0.37 mm (mean ± S.D). The F4 formulation produced a maximum percentage dissolution, permeation, and flux of 86.35 ± 0.576, 55.29 ± 0.127%, and 0.5532 ug/cm2/min, respectively. Conclusions: The present study therefore, suggests the use of S. acmella extract and olive oil containing emulgel for treating bacterial skin infections.

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Ding, Tingting, Jiajia Qi, Jingcheng Zou, Hongxia Dan, Hang Zhao e Qianming Chen. "A multifunctional supramolecular hydrogel for infected wound healing". Biomaterials Science 10, n. 2 (2022): 381–95. http://dx.doi.org/10.1039/d1bm01575c.

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45

Lapinska, Barbara, Magdalena Konieczka, Beata Zarzycka, Krzysztof Sokolowski, Janina Grzegorczyk e Monika Lukomska-Szymanska. "Flow Cytometry Analysis of Antibacterial Effects of Universal Dentin Bonding Agents on Streptococcus mutans". Molecules 24, n. 3 (1 febbraio 2019): 532. http://dx.doi.org/10.3390/molecules24030532.

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Abstract (sommario):

There is no consensus on the antibacterial activity of dentin bonding systems (DBS). Many study models have been used to evaluate the antimicrobial activity of dental materials. In this study, a novel detection method, flow cytometry, was introduced. It allows for evaluation of the antibacterial activity of DBS, based on assessment of the disruption of the bacterial physical membrane induced by DBS. The aim of the study was to evaluate the antibacterial properties of selected dentin bonding systems against Streptococcus mutans. The highest antibacterial activity against S. mutans was observed for Adhese Universal (99.68% dead cells) and was comparable to that of Prime&Bond Universal, OptiBond Universal, or Clearfil Universal Bond Quick (p > 0.05). The lowest activity of all tested systems was displayed by the multi-mode adhesive, Universal Bond (12.68% dead bacteria cells), followed by the self-etch adhesive, OptiBond FL (15.58% dead bacteria cells). The present study showed that in the case of two-component DBS, the primer exhibited higher antimicrobial activity than the adhesive (or bond) itself.

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Ferreira, Carolina, Vicente Leitune, Gabriela Balbinot, Felipe Degrazia, Marianna Arakelyan, Salvatore Sauro e Fabricio Mezzomo Collares. "Antibacterial and Remineralizing Fillers in Experimental Orthodontic Adhesives". Materials 12, n. 4 (21 febbraio 2019): 652. http://dx.doi.org/10.3390/ma12040652.

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Abstract (sommario):

Orthodontic adhesives with antimicrobial and remineralizing properties may be an alternative to control white spot lesions around brackets. The aim of this study is to develop an experimental orthodontic adhesive containing boron nitride nanotubes (BNNT) and alkyl trimethyl ammonium bromide (ATAB). Methacrylate (BisGMA and TEGDMA) monomers were used to formulate the adhesives. Four experimental groups were produced with the addition of 0.1 wt.% BNNT (GBNNT); 0.1 wt.% ATAB (GATAB); and 0.2 wt.% BNNT with ATAB (GBNNT/ATAB); in the control group, no fillers were added (GCtrl). The degree of conversion, cytotoxicity, softening in solvent, contact angle and free surface energy, antibacterial activity, shear bond strength, and mineral deposition were evaluated. Adhesives achieved degree of conversion higher than 50% and cell viability higher than 90%. GBNNT and GATAB adhesives exhibited reduced softening in solvent. Mean free surface energy was decreased in the GBNNT adhesive. Significant reduction in bacterial growth was observed in the GBNNT/ATAB. No statistical difference was found for shear bond strength. Mineral deposition was found in GBNNT, GATAB, and GBNNT/ATAB groups after 14 and 28 days. The addition of 0.2% BNNT/ATAB to an experimental orthodontic adhesive inhibited bacterial growth and induced mineral deposition without affecting the properties of the material.

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Rao, Kummara Madhusudana, Kannan Badri Narayanan, Uluvangada Thammaiah Uthappa, Pil-Hoon Park, Inho Choi e Sung Soo Han. "Tissue Adhesive, Self-Healing, Biocompatible, Hemostasis, and Antibacterial Properties of Fungal-Derived Carboxymethyl Chitosan-Polydopamine Hydrogels". Pharmaceutics 14, n. 5 (10 maggio 2022): 1028. http://dx.doi.org/10.3390/pharmaceutics14051028.

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In this work, fungal mushroom-derived carboxymethyl chitosan-polydopamine hydrogels (FCMCS-PDA) with multifunctionality (tissue adhesive, hemostasis, self-healing, and antibacterial properties) were developed for wound dressing applications. The hydrogel is obtained through dynamic Schiff base cross-linking and hydrogen bonds between FCMCS-PDA and covalently cross-linked polyacrylamide (PAM) networks. The FCMCS-PDA-PAM hydrogels have a good swelling ratio, biodegradable properties, excellent mechanical properties, and a highly interconnected porous structure with PDA microfibrils. Interestingly, the PDA microfibrils were formed along with FCMCS fibers in the hydrogel networks, which has a high impact on the biological performance of hydrogels. The maximum adhesion strength of the hydrogel to porcine skin was achieved at about 29.6 ± 2.9 kPa. The hydrogel had good self-healing and recoverable properties. The PDA-containing hydrogels show good antibacterial properties on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) bacteria. Moreover, the adhesive hydrogels depicted good viability and attachment of skin fibroblasts and keratinocyte cells. Importantly, FCMCS and PDA combined resulted in fast blood coagulation within 60 s. Hence, the adhesive hydrogel with multifunctionality has excellent potential as a wound dressing material for infected wounds.

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48

Schiroky, Priscila Raquel, Vicente Castelo Branco Leitune, Isadora Martini Garcia, Fabrício Aulo Ogliari, Susana Maria Werner Samuel e Fabrício Mezzomo Collares. "Triazine Compound as Copolymerized Antibacterial Agent in Adhesive Resins". Brazilian Dental Journal 28, n. 2 (aprile 2017): 196–200. http://dx.doi.org/10.1590/0103-6440201701346.

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Abstract (sommario):

Abstract The aim of this study was to formulate and evaluate an experimental adhesive resin with the addition of 1,3,5-triacryloylhexahydro-1,3,5-triazine at different concentrations. Experimental adhesive resins were obtained by mixing 50% wt bisphenol A glycol dimethacrylate (BisGMA), 25% wt triethylene glycol dimethacrylate (TEGDMA), 25% wt 2-hydroxyethyl methacrylate (HEMA) and photoinitiator system. The triazine compound was added in 1, 2.5 and 5% wt to a base adhesive resin and one group remained with no triazine as control group. The experimental adhesive resins were analyzed for antibacterial activity (n=3), degree of conversion (n=3) and softening in solvent (n=3). Data distribution was evaluated by Kolmogorov-Smirnov test, paired t test, one-way ANOVA and Tukey’s with a 0.05 level of significance. All groups with added triazine compound showed antibacterial activity against Streptococcus mutans (p<0.05). All groups achieved more than 70% degree of conversion, but there was no difference in this chemical property (p>0.05). The initial Knoop hardness was higher in 2.5 and 5% wt groups (p<0.05) and both groups present lower percentage variation of Knoop hardness after solvent degradation. The present study formulated an antibacterial adhesive resin with a non-releasing agent able to copolymerize with the comonomeric blend, improving the restorative material’s properties.

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49

Han, Xiaoman, Guihua Meng, Qian Wang, Lin Cui, Hao Wang, Jianning Wu, Zhiyong Liu e Xuhong Guo. "Mussel-inspired in situ forming adhesive hydrogels with anti-microbial and hemostatic capacities for wound healing". Journal of Biomaterials Applications 33, n. 7 (22 novembre 2018): 915–23. http://dx.doi.org/10.1177/0885328218810552.

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Abstract (sommario):

All kinds of commercially available wound dressings are clinically used as fleshly obstacles and therapeutic materials in opposition to microbial incursion. Few researches focused on effective-bleeding and anti-bacteria at the same time. In order to better solve this problem, two hydrogels were synthetized in this study. One is phosphate buffer solution-activated dopamine-modified-γ-poly glutamic acid (PBS-PD) hydrogel, the other one is cirsium setosum extracts-activated dopamine-modified-γ-poly glutamic acid (CSE-PD) hydrogel. The two hydrogels are prepared by applying an enzyme-catalyzed crosslinking means in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H2O2). The chemical structures were characterized through 1H-NMR and FT-IR. In conclusion, both PBS-PD and CSE-PD hydrogels exhibit superior tissue adhesion properties, and remarkable anti-infection quality. In addition, these two hydrogels manifest prominent hemostatic efficiency. The bio adhesion performance can achieve 30 kPa, meanwhile the CSE-PD hydrogels show good germicidal properties, and the antibacterial rate can reach 98%. The hydrogels could reduce blood loss without any obvious side effect, and present a new prospect in the field of hemostasis rapidly.

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Altankhishig, Bayarchimeg, Yasuhiro Matsuda, Futami Nagano-Takebe, Katsushi Okuyama, Hiroko Yamamoto, Masahiko Sakurai, Katsuaki Naito et al. "Potential of Fluoride-Containing Zinc Oxide and Copper Oxide Nanocomposites on Dentin Bonding Ability". Nanomaterials 12, n. 8 (11 aprile 2022): 1291. http://dx.doi.org/10.3390/nano12081291.

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Abstract (sommario):

Despite recent advances in bonding restorations, which are the basis of restorative dentistry, secondary caries are still able to form. Previously, a novel fluoride-containing zinc and copper (ZCF) nanocomposite was introduced to prevent the formation of caries due to its antibacterial activity. In this study, we studied the impact of ZCF nanoparticles on the adhesive strength of bonding restorations through micro-tensile bond strength (µTBS) testing. The impact of antibacterial and matrix metalloproteinase (MMP) inhibitors on the nanoparticles was also examined. The nanocomposites were prepared using a simple one-step homogeneous co-precipitation method at a low temperature. A self-etch adhesive was applied to 10 extracted caries-free human molars with (test group) and without (control group) the ZCF nanoparticles. This was followed by composite resin build-up and µTBS testing, MMP activity assays, and evaluation of the antibacterial effects. The results showed no significant differences in the µTBS between the ZCF and the control groups. However, the ZCF exhibited a significant inhibitory effect against MMP-2, MMP-8, and MMP-9, in addition to an antibacterial effect on Streptococcus mutans. Therefore, the present study demonstrated that the addition of ZCF nanoparticles to adhesive systems can result in MMP inhibition and antibacterial action while maintaining the mechanical properties of the bonding restorations.

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