Tesi sul tema "Ancestral"
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1
Josefsson, Erik. "Progression of ancestral brutalism". Thesis, Högskolan i Borås, Institutionen Textilhögskolan, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-17068.
Testo completoAbstract (sommario):
Within the fine arts, clean and flat structures functionas a narrator for the clean, modern and hightech society. A society with a hygienic fear of death, illness and chaotic structures. The aim of the work is through the materialand surface inflict the hidden, the other side, the darkness and death, in strict and formal mens archetype garments.Program: Modedesignutbildningen
2
Ballón, Aguirre Enrique. "Tradición oral ancestral peruana". Pontificia Universidad Católica del Perú, 2014. http://repositorio.pucp.edu.pe/index/handle/123456789/113743.
Testo completo
3
Graf, Jaz. "Geographies of ancestral embodiment". Thesis, University of Iowa, 2019. https://ir.uiowa.edu/etd/6748.
Testo completoAbstract (sommario):
Throughout history, humankind has looked to the natural world for understanding the foundations of life and the essence of existence. Emphasizing states of sedimentary material, as physical and metaphorical reference to the cyclical complexion of life/death, growth/decay, transformation/stasis…I investigate the meaning of familial roots, reimagining humanity’s relationship to earth. The ways in which this connection can be understood are dependent on visual or symbolic representations and through experiential knowledge of sensing physicality and materiality.
4
Parrado, Tony. "Improved Individual Ancestry Estimates for Proper Adjustment of Ancestral Confounding in Association Analysis". Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1216340419.
Testo completo
5
Hernández, García Jorge. "Ancestral Functions of DELLA Proteins". Doctoral thesis, Universitat Politècnica de València, 2021. http://hdl.handle.net/10251/169370.
Testo completoAbstract (sommario):
[ES] Las plantas necesitan acomodar su crecimiento a las condiciones ambientales. Con el objetivo de ajustar su desarrollo a las señales externas, usan una serie de mecanismos moleculares. Uno de estos son las rutas de señalización hormonal, que participan en integrar la información externa con programas de desarrollo propios. Una de las hormonas más relevantes en la biología vegetal son las giberelinas (GAs). La señalización por GAs se inicia con la percepción de la hormona a través del receptor GID1, y continúa por la degradación de las reguladoras transcripcionales DELLA. Sin embargo, solo las plantas vasculares tienen un sistema de percepción de GAs completo. Entender la relevancia de la señalización por GAs requiere estudiar cómo se ensambló la ruta y qué funciones atribuidas a las GAs estaban ya codificadas en las proteínas DELLA ancestrales. Aquí mostramos mediante análisis filogenéticos y bioquímicos que las proteínas DELLA emergieron inequívocamente en un ancestro común de las plantas terrestres, y que el reclutamiento de las DELLAs al módulo de percepción de GAs depende de la presencia de un dominio de transactivación conservado que fue co-optado por el receptor GID1 ancestral para actuar como un degrón dependiente de GAs. Este dominio de transactivación parece regular la co-activación transcripcional de genes concretos por las DELLAs en todas las plantas terrestres mediante el reclutamiento de complejos Mediator a través de su subunidad MED15. Por último, nos hemos centrado en entender las funciones de las proteínas DELLA en briófitas, un clado sin señalización por GAs. Hemos descubierto el rol de la DELLA de Marchantia polymorpha como coordinadora entre las respuestas de crecimiento y estrés, sugiriendo que dicha función estaba ya codificada en proteínas DELLA del ancestro común de plantas terrestres y se ha mantenido durante más de 450 millones de años.[CA] Les plantes necessiten acomodar el seu creixement a les condicions ambientals. Amb l'objectiu d'ajustar el seu desenvolupament als senyals externs, usen una sèrie de mecanismes moleculars. Un d'aquests són les rutes de senyalització hormonal, que participen en integrar la informació externa amb programes de desenvolupament propis. Una de les hormones més rellevants en la biologia vegetal són les giberel·lines (GAs). La senyalització per GAs s'inicia amb la percepció de l'hormona a través del receptor GID1, i continua per la degradació de les reguladores transcripcionals DELLA. No obstant això, només les plantes vasculars tenen un sistema complet de percepció de GAs. Entendre la rellevància de la senyalització per GAs requereix estudiar com es va assemblar la ruta i quines funcions atribuïdes a les GAs estaven ja codificades en les proteïnes DELLA ancestrals. Ací mostrem mitjançant anàlisis filogenètiques i bioquímiques que les proteïnes DELLA van emergir inequívocament en un ancestre comú de les plantes terrestres, i que el reclutament de les DELLAs al mòdul de percepció de GAs depén de la presència d'un domini de transactivació conservat que va ser co-optat pel receptor GID1 ancestral per a actuar com un degró dependent de GAs. Aquest domini de transactivació sembla regular la co-activació transcripcional de gens concrets per les DELLAs en totes les plantes terrestres mitjançant el reclutament de complexos Mediator a través de la seua subunitat MED15. Finalment, ens hem centrat en entendre les funcions de les proteïnes DELLA en briòfites, un clade sense senyalització per GAs. Hem descobert el rol de la DELLA de Marchantia polymorpha com a coordinadora entre les respostes de creixement i estrés, suggerint que aquesta funció estava ja codificada en proteïnes DELLA de l'ancestre comú de plantes terrestres i s'ha mantingut durant més de 450 milions d'anys.
[EN] Plants need to accommodate their growth habits to environmental conditions. For this aim, several mechanisms are used to adjust developmental responses to exogenous signals. Among them, hormonal signalling pathways participate by integrating external information with endogenous programs. One of the most relevant hormones in plant biology are gibberellins (GAs). GA signalling involves perception of the hormone by the GA receptor GID1 and subsequent degradation of the DELLA transcriptional regulators. However, only vascular plants possess a full GA perception system. Understanding the relevance of GA signalling requires elucidating how this pathway was assembled and which of the functions attributed to GAs were encoded in the ancestral DELLA proteins. Here we show by phylogenetic and biochemical analyses that DELLA proteins emerged unequivocally in a land plant common ancestor and that their recruitment into the GA-perception module relies in the presence of a conserved transactivation domain co-opted by an ancestral GID1 receptor to act as a GA-dependent degron. Moreover, this transactivation domain seems to regulate DELLA-dependent transcriptional co-activation of selected target genes by recruitment of Mediator complexes through the MED15 subunit in all land plants. Finally, we have focused on understanding the functions of DELLA proteins in bryophytes, a clade with no GA signalling. We have uncovered the role of Marchantia polymorpha DELLA protein as a coordinator between growth and stress responses, suggesting that this function was already present in the DELLA protein of a land plant common ancestor and has been maintained for over 450 millions of years.
La realización de esta tesis doctoral ha sido posible gracias a una ayuda para contratos predoctorales FPU (FPU15/01756), dos Ayudas para Estancias Breves FPU (EST17/00237, IPS2, París; EST18/00400, WUR, Wageningen), una ayuda EMBO Short-Term (ASTF 8239, WUR, Wageningen), y la financiación MSCA H2020 RISE para desplazamientos en el contexto del proyecto SIGNAT (RISE Action 644435, PUC, Santiago). Así mismo, el grueso del trabajo experimental incluido ha sido financiado por el proyecto HUBFUN del MINECO (BFU2016-80621-P)
Hernández García, J. (2021). Ancestral Functions of DELLA Proteins [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/169370
TESIS
6
Yang, Kuan. "Ancestral Genome Reconstruction in Bacteria". Diss., Virginia Tech, 2012. http://hdl.handle.net/10919/28091.
Testo completoAbstract (sommario):
The rapid accumulation of numerous sequenced genomes has provided a golden opportunity for ancestral state reconstruction studies, especially in the whole genome reconstruction area. However, most ancestral genome reconstruction methods developed so far only focus on gene or replicon sequences instead of whole genomes. They rely largely on either detailed modeling of evolutionary events or edit distance computation, both of which can be computationally prohibitive for large data sets. Hence, most of these methods can only be applied to a small number of features and species. In this dissertation, we describe the design, implementation, and evaluation of an ancestral genome reconstruction system (REGEN) for bacteria. It is the first bacterial genome reconstruction tool that focuses on ancestral state reconstruction at the genome scale instead of the gene scale. It not only reconstructs ancestral gene content and contiguous gene runs using either a maximum parsimony or a maximum likelihood criterion but also replicon structures of each ancestor. Based on the reconstructed genomes, it can infer all major events at both the gene scale, such as insertion, deletion, and translocation, and the replicon scale, such as replicon gain, loss, and merge. REGEN finishes by producing a visual representation of the entire evolutionary history of all genomes in the study. With a model-free reconstruction method at its core, the computational requirement for ancestral genome reconstruction is reduced sufficiently for the tool to be applied to large data sets with dozens of genomes and thousands of features. To achieve as accurate a reconstruction as possible, we also develop a homologous gene family prediction tool for preprocessing. Furthermore, we build our in-house Prokaryote Genome Evolution simulator (PEGsim) for evaluation purposes. The homologous gene family prediction refinement module can refine homologous gene family predictions generated by third party de novo prediction programs by combining phylogeny and local gene synteny. We show that such refinement can be accomplished for up to 80% of homologous gene family predictions with ambiguity (mixed families). The genome evolution simulator, PEGsim, is the first random events based high level bacteria genome evolution simulator with models for all common evolutionary events at the gene, replicon, and genome scales. The concepts of conserved gene runs and horizontal gene transfer (HGT) are also built in. We show the validation of PEGsim itself and the evaluation of the last reconstruction component with simulated data produced by it. REGEN, REconstruction of GENomes, is an ancestral genome reconstruction tool based on the concept of neighboring gene pairs (NGPs). Although it does not cover the reconstruction of actual nucleotide sequences, it is capable of reconstructing gene content, contiguous genes runs, and replicon structure of each ancestor using either a maximum parsimony or a maximum likelihood criterion. Based on the reconstructed genomes, it can infer all major events at both the gene scale, such as insertion, deletion, and translocation, and the replicon scale, such as replicon gain, loss, and merge. REGEN finishes by producing a visual representation of the entire evolutionary history of all genomes in the study.Ph. D.
7
Harrison, David Christopher James. "Ancestral subject catalogue of chapbook themes". Thesis, University of Surrey, 1996. http://epubs.surrey.ac.uk/844333/.
Testo completoAbstract (sommario):
This thesis seeks to offer a substantial bibliographical resource for the study of chapbook literature in the early-modern period. It lists all titles known to have been published in the 'prestructure' (or format) of the chapbook before 1700. Furthermore it details the development of titles and themes from their earliest cultural origins (whether in the form of folk-plays, or printed literature). The inclusion of items associated by theme and subject allows the texts themselves to be shown in the context of other printed productions of the time that relate to them. There is no hard and fast rule here. Some texts are associated by title similarity, some by subject similarity, and some by the use of the same theme. As well as including associated texts for each title, they are often given for groups of titles (ie. gender, medical, cookery, anti-Welsh). These are not comprehensive lists. In each case the basis for the selection will be given. The section numbers will correspond with those of the relevant sections of a forthcoming comprehensive study of the origin and development of chapbook literature to 1700. The basic layout runs from Tales (early romances - popular legends - rogues and jests - apprentice literature) through didactic texts (incl. gender), and fables to conduct texts that use narrative, and then those which don't (complement books). Next come other 'how-to' guides. Then garlands, 'useful' information, riddles and trivia. The work continues with miscellanies, and concludes with texts relating to the production and distribution of cheap print. The general movements within sections or within the whole are from fiction to non-fiction, and from texts with earlier origins to those with later, complementing the prose study. The main titles in each section are ordered alphabetically by keywords and preceded by an index. Each entry is chronologically ordered.
8
Kaati, Gunnar. "Ancestral influences on health of grandchildren /". Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-300-0/.
Testo completo
9
Beucher, Julie. "Haplotype ancestral AH8.1 dans la mucoviscidose". Phd thesis, Université Pierre et Marie Curie - Paris VI, 2012. http://tel.archives-ouvertes.fr/tel-00827653.
Testo completoAbstract (sommario):
La mucoviscidose est une maladie à transmission autosomique récessive, due à des mutations du gène CFTR. Les patients, partageant de mêmes mutations de CFTR et un même environnement, ont une expression phénotypique variable, suggérant l'influence d'autres gènes modifiant la sévérité de la maladie, appelés gènes modificateurs. L'atteinte respiratoire, caractérisée par une inflammation exacerbée, est un facteur principal de morbimortalité. L'haplotype ancestral AH8.1, impliqué dans la réponse inflammatoire, est constitué de 4 variants : LTa +252A/G, TNF -308G/A, HSPA1B +1267A/G et AGER -429T/C. Ainsi, l'objectif était de rechercher une association entre l'haplotype AH8.1 et la sévérité de l'atteinte respiratoire. Nous avons montré dans une cohorte de 404 patients européens, porteurs de différentes mutations de CFTR, que AH8.1 était associé au déclin de la fonction respiratoire. Nous avons taché de répliquer nos résultats dans une cohorte homogène de 1089 patients français, F508del homozygotes, sans succès à ce jour. Nous poursuivons cette étude chez des patients porteurs d'autres mutations de CFTR. Les variants de cet haplotype ont également été étudié séparément. Nous avons ainsi montré que AGER-429T/C, non seulement modulait la sévérité de l'atteinte respiratoire, mais, était également associé in vitro à une plus grande production de la protéine RAGE. L'ensemble de ces résultats suggère à ce jour que l'haplotype AH8.1 pourrait moduler la sévérité de l'atteinte respiratoire des patients non homozygotes pour la mutation CFTR F508del. De plus, le variant AGER-429T/C seul, modulant la sévérité de l'atteinte respiratoire, la protéine RAGE pourrait être envisagée comme biomarqueur dans la mucoviscidose. Mots clés : mucoviscidose - gène modificateur - haplotype ancestral AH8.1 - RAGE
10
MacLeod, Andrew Keith. "Detecting ancestral junctions in inbred populations". Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/17024.
Testo completoAbstract (sommario):
This thesis presents theoretical results on the number of junctions on chromosomes in partially inbred populations, and addresses problems posed by locating these junctions using markers in both simulated populations and recombinant inbred lines (RILs). Chapter 1 presents a general introduction to the concept of junctions, and reviews previous work on the theory. Chapter 2 confirms by simulation some of the results presented in chapter 1, and shows that in a population of size N where selfing is excluded, but otherwise mating at random, the expected number of junctions per Morgan on a chromosome is linearly related to the inbreeding coefficient of that population, until complete inbreeding where 2(N+1) junctions are expected. Chapter 2 investigates the efficiency of using markers to detect junctions in inbred populations. Even with a highly dense map of fully informative markers, not all of the junctions present are detected, with the actual detection rate lower than expected if junctions were distributed at random. An approximate expression for the proportion of junctions detected 1/(1+1.4γ), where γ = J/B, the ratio of junctions to marker brackets Chapter 3 applies the theory of junctions to RILs. Theoretical analysis suggests a density of 4 junctions per Morgan in a RIL. The observed counts of junctions detected using microsatellite markers in multiple RILs are found to be slightly lower than this expectation. In the analysis of junctions detected, “cross” and “line” were found to have significant effects in the analysis. Chapter 5 attempts to further elucidate the factors affecting observed junction counts in RILs by looking at the effects of individual markers on the junction count to locate specific regions of the genome that affect junction formation.
11
Azevedo, Vanda Alves Torres. "Ìyàmi: símbolo ancestral feminino no Brasil". Pontifícia Universidade Católica de São Paulo, 2006. https://tede2.pucsp.br/handle/handle/1982.
Testo completoAbstract (sommario):
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Ìyàmi, primordial mother, deity of practical the religious Afro-Brazilians in its originary symbol, are our object of study. Ìyàmi is basic in the cults of African origin. To study and to investigate the real knowledge on the conception of ìyàmi, its venerability,its influence in the practical one of the cult to òrìsàs, as well as its symbols, its celebration, its prayers and its praises are our objectives. To rescue the identity of Ìyàmi is arduous task, therefore it implies in the overcoming of the preconception and the duturpation reductia vision that if made on the feminine ancestral aspect. Ìyàmi ancestral mother, mythical deity,collective representation of the feminine ancestral genitor entities, deity of practical the religious Afro-Brazilians. Ìyàmi came to Brazil with descendants of populations of Africa Occidental person, primordial, matrix first of which begin all the creation of the material world
Ìyàmi, mãe primordial, divindade das práticas religiosas afro-brasileiras em seu símbolo originário, é nosso objeto de estudo. Ìyàmi é fundamental nos cultos de origem africna. Estudar e investigar os conhecimentos reais sobre a concepção de Ìyàmi, sua venerabilidade, sua influência na prática do culto aos orixás, bem como seus símbolos, sua celebração, suas rezas e suas louvações são os nosso objetivos. Resgatar a identidade de Ìyàmi é tarefa árdua, pois implica na superação do preconceito e da visão redutiva deturpada que se fez sobre o aspecto ancestral feminino. Ìyàmi, Mãe Ancestral, divindade mítica, representação coletiva das entidades genitoras ancestrais femininas, divindade das práticas afro-brasileiras. Ìyàmi veio para o Brasil com descendentes de populações da África Ocidental, mãe primordial, matriz primeira da qual advém toda a criação do mundo material
12
Beucher, Julie. "Haplotype ancestral AH8. 1 dans la mucoviscidose". Paris 6, 2012. http://www.theses.fr/2012PA066142.
Testo completoAbstract (sommario):
La mucoviscidose est une maladie à transmission autosomique récessive, due à des mutations du gène CFTR. Les patients, partageant de mêmes mutations de CFTR et un même environnement, ont une expression phénotypique variable, suggérant l'influence d’autres gènes modifiant la sévérité de la maladie, appelés gènes modificateurs. L’atteinte respiratoire, caractérisée par une inflammation exacerbée, est un facteur principal de morbi-mortalité. L’haplotype ancestral AH8. 1, impliqué dans la réponse inflammatoire, est constitué de 4 variants : LTa +252A/G, TNF -308G/A, HSPA1B +1267A/G et AGER -429T/C. Ainsi, l’objectif était de rechercher une association entre l’haplotype AH8. 1 et la sévérité de l’atteinte respiratoire. Nous avons montré dans une cohorte de 404 patients européens, porteurs de différentes mutations de CFTR, que AH8. 1 était associé au déclin de la fonction respiratoire. Nous avons taché de répliquer nos résultats dans une cohorte homogène de 1089 patients français, F508del homozygotes, sans succès à ce jour. Nous poursuivons cette étude chez des patients porteurs d’autres mutations de CFTR. Les variants de cet haplotype ont également été étudié séparément. Nous avons ainsi montré que AGER-429T/C, non seulement modulait la sévérité de l’atteinte respiratoire, mais, était également associé in vitro à une plus grande production de la protéine RAGE. L’ensemble de ces résultats suggère à ce jour que l’haplotype AH8. 1 pourrait moduler la sévérité de l’atteinte respiratoire des patients non homozygotes pour la mutation CFTR F508del. De plus, le variant AGER-429T/C seul, modulant la sévérité de l’atteinte respiratoire, la protéine RAGE pourrait être envisagée comme biomarqueur dans la mucoviscidoseCystic fibrosis is an autosomic recessive disease due to mutations in the gene CFTR. There is a great phenotypic variability among patients with identical mutations and with identical environment. These data suggest that others genes, called modifier genes, may affect the lung phenotype. Lung disease, characterized by airway inflammation, is a key component of morbi-mortality. The ancestral haplotype AH8. 1, involved in the inflammatory response, is composed of 4 variants: LTa +252A/G, TNF -308G/A, HSPA1B +1267A/G and AGER -429T/C. The aim of the study was to test whether this haplotype AH8. 1 was associated with lung disease severity in cystic fibrosis. We showed in a cohort of 404 European patients, carriers of different mutations of CFTR, that AH8. 1 is associated with a greater lung disease severity. We did not succeed to replicate our results in a homogeneous cohort of 1039 French patients F508del homozygotes. We proceed with this study in patients, carriers of other CFTR mutations. Variants of this haplotype were also studied separately. We have shown that AGER-429T/C, not only modulates the severity of lung disease, but was also associated in vitro with a greater production of the protein RAGE. All these results suggest to date that AH8. 1 haplotype could modulate the lung disease severity in patients not homozygous for the F508del CFTR mutation. Moreover, the variant AGER-429T/C modulated the lung disease severity and the protein RAGE may be considered as a biomarker in cystic fibrosis
13
Milne, Margaret Georgina. "Environmental niche evolution and ancestral niche reconstruction". Thesis, Queen's University Belfast, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709832.
Testo completoAbstract (sommario):
Quantifying the diversity and distribution of the world’s biota in both space and time is a fundamental goal of modern biology, however ecologists also face the added pressure of understanding how species may respond to anthropogenically driven environmental changes. The relationship between species distributions and the environment can be captured in Environmental Niche Models (ENM’s), which create mathematical models linking species occurrences to ecological factors at a specific point in time. Whilst this approach is very useful, it can be improved by the incorporation of phylogenetic data (with estimated species divergence dates) to explore how the environmental niche has changed for a whole clade through evolutionary time. This thesis aims to explore whether niches are conserved over the life history for individual species, and for entire genera through evolutionary time. The research aims to firstly improve the current iteration of the Coleopteran Mutual Climatic Range (MCR) approach by automating the climate envelope creation process; secondly, to determine whether the expression of the realised climate niche has changed for four members of the Staphylinid Olophrum genus through the Quaternary and thirdly, to create a historical bio-geographical model indicating the likely mode of evolution between sister-taxa in the Dytiscidae Hydroporus genus. Lastly, the ancestral climatic niche of the Hydroporus genus is modelled in order to determine any patterns in climate niche evolution. This is achieved by bringing together phylogenetic data, occurrence data and environmental data under a Bayesian analysis framework to reconstruct the values for environmental niche traits at internal nodes in a phylogenetic tree.
14
Kruschwitz, Jonathan A. "Interludes and irony in the ancestral narrative". Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/9320/.
Testo completoAbstract (sommario):
The strange stories of Hagar, Dinah, and Tamar unsettle the ancestral narrative in Genesis. Whereas the ancestral narrative revolves around the interests of the ancestral family, these stories deviate from the main plot and draw attention to the interests of non- ancestral characters. Interpretation traditionally domesticates the strange stories by focusing on how they may serve the purposes of the embedding ancestral narrative. This thesis, however, revives the question of their strangeness and proposes an original response: the strange stories are interludes that ironize ancestral identity. The concepts of interlude and irony lay the methodological groundwork for this thesis. Because scholarship commonly identifies the strange stories as “interludes,” this study innovates a poetics of the interlude. This poetics, which derives from the model of certain musical interludes, suggests that the interlude’s function is to develop primary thematic content. While scholarship conventionally allows the primary narrative to determine the significance of the interlude, this poetics illumines how the interlude may determine aspects of the primary narrative. A hermeneutics of irony, in turn, offers a persuasive account of how an interlude may develop primary thematic material. This study bases its hermeneutics on the idea that irony consists in quoting a prior proposition and implying a negative judgment toward it. When the interludes invoke central ancestral motifs, they may mean something different—even contrary—to what was meant before. A poetics of the interlude and a hermeneutics of irony drive this study’s close readings of the strange stories. The close readings demonstrate how the interludes ironize key themes of ancestral identity: the ancestral-divine relationship, ancestral relations to the land and its inhabitants, and ancestral self-identity. Each interlude subverts the conventionally exclusive formulation of an ancestral theme and shows that, while ancestral identity may be contained in the ancestral family, it is not contained by it.
15
Holmberg, Larsson Albin. "Biochemical characterization of resurrected ancestral ammonia lyases". Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-261355.
Testo completoAbstract (sommario):
This study set out to express, purify and characterize twelve ammonia lyase enzymes for potential application as a supplement to a treatment of an inborn error of metabolism disease. The DNA sequence for two wild-type ammonia lyases, three modified ammonia lyases and seven resurrected ancestral ammonia lyases had been synthesized and cloned in vectors. These were transformed into Escherichia coli, expressed, purified using immobilized metal affinity chromatography and size exclusion chromatography and characterized. Ten of the enzymes were successfully expressed and purified. All enzymes had a higher turnover number with substrate 1 than with substrate 2. The wild-types showed the highest catalytic turnover and one of them displayed substrate cooperativity. The modified enzymes were inactive. Some ancestral enzymes were active and had decreasing kcat with age. A promising ancestral enzymes was found that showed a kcat of 2,85 s-1 with substrate 1 and 1,82 s-1 with substrate 2. The ancestral enzymes had a lower Km with substrate 2 compared to substrate 1, while one of the wild-types had a higher Km with substrate 2 than with substrate 1, indicating that the substrate affinity has switched. The ancestral enzymes had increased thermostability compared to the wild-types which increased with age. Ranging from a +7C increase in melting temperature with the youngest ancestral enzyme to +10,7C with the oldest tested enzyme, comparing with one of the wild-types. The promising ancestral enzyme displayed a higher stability than the wild-types during long term incubation in 37_C and 25_C, since it did not become prone to aggregation,it did not show visible degradation on SDS-PAGE and it retained the highest activity following incubation. It was also demonstrated that neither wild-types nor the promising ancestral enzyme were stable in a simulated gut environment. The promising ancestral enzyme and one of the wild-types degraded substrate 1 and 2 in serum. Using the resurrection of ancestral sequences a promising enzyme has been produced and characterized, displaying properties that are desired in therapeutic enzymes. The enzyme did not aggregate or become prone to aggregation over time, it was thermostable, it was active in serum and had acceptable catalytic properties. For therapeutic application of the ancestral enzyme, immunogenicty should be analyzed in silico and in vitro followed by further investigation in vivo.Målet med denna studie var att uttrycka, rena och karaktärisera tolv ammonia lyase enzymer, för potentiell användning som komplement till en behandling utav en sjukdom, som tillhör sjukdomsgruppen medfödda ämnesomsättningsrubbningar. DNA sekvensen för två vild-typammonia lyaser, tre modifierade ammonia lyaser och sju återuppväckta ammonia lyaser hade blivit syntetiserade och klonade i vektorer. E.coli celler blev transformerade med vektorerna, vilka uttryckte enzymerna, som renades med hjälp av immobilized metal affinity chromatography och gelfiltrering och karaktäriserades. Tio utav enzymerna kunde uttryckas och renas. Alla enzymer hade högre katalytisk omsättning av substrat 1 än substrat 2. Vildtyperna hade högst kcat med båda substrat och en utav dem uppvisade substratsammarbete. De modifierade enzymerna var inaktiva. Några av de återuppväckta ammonia lyaserna var aktiva och kcat minskade med ålder. Ett av de återuppväckta enzymerna var lovande och hade ett kcat värde av 2,85 s-1 med substrat 1 och 1,82 s-1 med substrat 2. De återuppväckta enzymerna hade ett lägre Km värde för substrat 2 än substrat 1, jämfört med en utav vildtyperna som hade ett högre Km värde för substrat 2 än substrat 1, vilket indikerar ett skifte i substrataffinitet. De återuppväckta enzymerna var mer termostabilia än vild-typerna och termostabiliteten ökar med ålder. Ökningen i smälttemperatur låg i spannet av +7C för de yngsta återuppväckta enzymerna till + 10,7C för det äldsta testade återuppväckta enzymet, vid jämförelse med en utav vild-typerna. Det lovande återuppväckta enzymet demonstrerade även en högre stabilitet än vild-typerna under långtidsinkubering, eftersom den inte blev benägen att aggregera, den uppvisade ingen nedbrytning på SDS-PAGE och den behöll högst aktivitet efter inkubering. Det bevisades även att varken vild-typerna eller det lovande återuppväckta enzymet var stabila i en simulerad magsäcksmiljö. Både det lovande återuppväckta enzymet och en av vild-typerna bröt ner substrat 1 och 2 i serum. Genom att återuppväcka sekvenser kunde ett lovande enzym produceras och karaktäriseras, vilket uppvisade egenskaper som är eftertraktade i terapeutiska enzymer. Enzymet aggregerade ej, det blev inte benäget att aggregera över tid, det var termostabilt, det var aktivt i serum och hade acceptabla katalytiska egenskaper. För terapeutisk applikation av det återuppväckta enzymet, borde analys av dess immunogenicitet utföras in silico och in vitro följt av vidare undersökning in vivo.
16
Groves, Nicole. "Ancestral Sequence Reconstruction of Isopenicillin N Synthase". Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27111.
Testo completoAbstract (sommario):
β-Lactam antibiotics account for over 65% of global antibiotic use and their discovery revolutionised treatment of infectious disease. The bicyclic core of these molecules is formed by the enzyme isopenicillin N synthase (IPNS), which catalyses the oxidative double ring closure of substrate tripeptide δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine (ACV) to isopenicillin N (IPN).
This thesis presents research into the evolutionary origins of IPNS, and potential broader uses which exploit its broad substrate tolerance. Ancestral sequence reconstruction is used to predict the structures of eight ancestral proteins ranging from approximately 900 million to 4 billion years old. These proteins are modelled and key differences between extant and ancestral IPNS homologs are explored.
The ancestral proteins are then “resurrected” by bacterial expression, and two ancestors are found to turn over ACV into IPN. The ages of several of these ancestors predate the Great Oxygenation Event, where the abundance of molecular oxygen in the Earth’s atmosphere dramatically increased. It was therefore hypothesised that IPNS may have performed a different role in the past, before it had access to its O2 cofactor. Preliminary screening for alternate activity begins with the replacement of the Fe(II) centre with other metals and exposure of an alternate substrate.
Finally, work begins towards the synthesis of a tripeptide isostere of ACV, where the nitrogen of the cysteinyl-valine amide is replaced with carbon. Several potential routes to a cysteinyl-valine dipeptide isostere to be eventually coupled with protected L-α-aminoadipic acid are developed. We hypothesise that the IPNS ancestors purified in this study will be able to cyclise the structure into a cyclobutanone IPN homolog. This cyclobutanone homolog is the most basic of a class of β-lactam resistance inhibitors and could be used to enzymatically build a library of potential inhibitors for screening against resistant bacteria.
17
Habel, Chad Sean, e chad habel@gmail com. "Ancestral Narratives in History and Fiction: Transforming Identities". Flinders University. Humanities, 2006. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20071108.133216.
Testo completoAbstract (sommario):
This thesis is an exploration of ancestral narratives in the fiction of Thomas Keneally and Christopher Koch. Initially, ancestry in literature creates an historical relationship which articulates the link between the past and the present. In this sense ancestry functions as a type of cultural memory where various issues of inheritance can be negotiated. However, the real value of ancestral narratives lies in their power to aid in the construction of both personal and communal identities. They have the potential to transform these identities, to transgress natural boundaries and to reshape conventional identities in the light of historical experience.
For Keneally, ancestral narratives depict national forbears who narrate the nation into being. His earlier fictions present ancestors of the nation within a mythic and symbolic framework to outline Australian national identity. This identity is static, oppositional, and characterized by the delineation of boundaries which set nations apart from one another. However, Keneallys more recent work transforms this conventional construction of national identity. It depicts an Irish-Australian diasporic identity which is hyphenated and transgressive: it transcends the conventional notion of nations as separate entities pitted against one another. In this way Keneallys ancestral narratives enact the potential for transforming identity through ancestral narrative.
On the other hand, Kochs work is primarily concerned with the intergenerational trauma causes by losing or forgetting ones ancestral narrative. His novels are concerned with male gender identity and the fragmentation which characterizes a self-destructive idea of maleness. While Keneallys characters recover their lost ancestries in an effort to reshape their idea of what it is to be Australian, Kochs main protagonist lives in ignorance of his ancestors life. He is thus unable to take the opportunity to transform his masculinity due to the pervasive cultural amnesia surrounding his family history and its role in Tasmanias past.
While Keneally and Koch depict different outcomes in their fictional ancestral narratives they are both deeply concerned with the potential to transform national and gender identities through ancestry.
18
Randall, Ryan Nicole. "Experimental phylogenetics: a benchmark for ancestral sequence reconstruction". Thesis, Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/48998.
Testo completoAbstract (sommario):
The field of molecular evolution has benefited greatly from the use of ancestral sequence reconstruction as a methodology to better understand the molecular mechanisms associated with functional divergence. The method of ancestral sequence reconstruction has never been experimentally validated despite the method being exploited to generate high profile publications and gaining wider use in many laboratories. The failure to validate such a method is a consequence of 1) our inability to travel back in time to document evolutionary transitions and 2) the slow pace of natural evolutionary processes that prevent biologists from ‘witnessing’ evolution in action (pace viruses). In this thesis research, we have generated an experimentally known phylogeny of fluorescent proteins in order to benchmark ancestral sequence reconstruction methods. The tips/leaves of the fluorescent protein experimental phylogeny are used to determine the performances of various ASR methods. This is the first example of combining experimental phylogenetics and ancestral sequence reconstruction.
19
Zheng, Chunfang, Eric Chen, Victor Albert, Eric Lyons e David Sankoff. "Ancient eudicot hexaploidy meets ancestral eurosid gene order". BioMed Central, 2013. http://hdl.handle.net/10150/610022.
Testo completoAbstract (sommario):
BACKGROUND:A hexaploidization event over 125 Mya underlies the evolutionary lineage of the majority of flowering plants, including very many species of agricultural importance. Half of these belong to the rosid subgrouping, containing severals whose genome sequences have been published. Although most duplicate and triplicate genes have been lost in all descendants, clear traces of the original chromosome triples can be discerned, their internal contiguity highly conserved in some genomes and very fragmented in others. To understand the particular evolutionary patterns of plant genomes, there is a need to systematically survey the fate of the subgenomes of polyploids, including the retention of a small proportion of the duplicate and triplicate genes and the reconstruction of putative ancestral intermediates between the original hexaploid and modern species, in this case the ancestor of the eurosid clade.RESULTS:We quantitatively trace the fate of gene triples originating in the hexaploidy across seven core eudicot flowering plants, and fit this to a two-stage model, pre- and post-radiation. We also measure the simultaneous dynamics of duplicate orthologous gene loss in three rosids, as influenced by biological functional class. We propose a new protocol for reconstructing ancestral gene order using only gene adjacency data from pairwise genomic analyses, based on repeating MAXIMUM WEIGHT MATCHING at two levels of resolution, an approach designed to transcend limitations on reconstructed contig size, while still avoiding the ambiguities of a multiplicity of solutions. Applied to three high-quality rosid genomes without subsequent polyploidy events, our automated procedure reconstructs the ancestor of the eurosid clade.CONCLUSIONS:The gene loss analysis and the ancestor reconstruction present complementary assessments of post-hexaploidization evolution, the first at the level of individual gene families within and across sister genomes and the second at the chromosome level. Despite the loss of more than 95% of gene duplicates and triplicates, and despite major structural rearrangement, our reconstructed eurosid ancestor clearly identifies the three regions corresponding to each of the seven original chromosomes of the earlier pre-hexaploid ancestor. Functional analysis confirmed trends reported for more recent plant polyploidy events: genes involved with regulation and responses were retained in multiple copies, while genes involved with metabolic processes were lost.
20
Lammert, Eckhard, Vincent Laudet, Michael Schubert, Kathrin Regener, Boris Strilic e Tomas Kucera. "Ancestral vascular lumen formation via basal cell surfaces". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-184284.
Testo completoAbstract (sommario):
The cardiovascular system of bilaterians developed from a common ancestor. However, no endothelial cells exist in invertebrates demonstrating that primitive cardiovascular tubes do not require this vertebrate-specific cell type in order to form. This raises the question of how cardiovascular tubes form in invertebrates? Here we discovered that in the invertebrate cephalochordate amphioxus, the basement membranes of endoderm and mesoderm line the lumen of the major vessels, namely aorta and heart. During amphioxus development a laminin-containing extracellular matrix (ECM) was found to fill the space between the basal cell surfaces of endoderm and mesoderm along their anterior-posterior (A-P) axes. Blood cells appear in this ECM-filled tubular space, coincident with the development of a vascular lumen. To get insight into the underlying cellular mechanism, we induced vessels in vitro with a cell polarity similar to the vessels of amphioxus. We show that basal cell surfaces can form a vascular lumen filled with ECM, and that phagocytotic blood cells can clear this luminal ECM to generate a patent vascular lumen. Therefore, our experiments suggest a mechanism of blood vessel formation via basal cell surfaces in amphioxus and possibly in other invertebrates that do not have any endothelial cells. In addition, a comparison between amphioxus and mouse shows that endothelial cells physically separate the basement membranes from the vascular lumen, suggesting that endothelial cells create cardiovascular tubes with a cell polarity of epithelial tubes in vertebrates and mammals.
21
Juruna, Samantha Ro'otsitsina de Carvalho. "Sabedoria ancestral em movimento : perspectivas para a sustentabilidade". reponame:Repositório Institucional da UnB, 2013. http://repositorio.unb.br/handle/10482/13168.
Testo completoAbstract (sommario):
Dissertação (mestrado)—Universidade de Brasília, Centro de Desenvolvimento Sustentável, 2013.Submitted by Alaíde Gonçalves dos Santos (alaide@unb.br) on 2013-05-21T14:51:57Z No. of bitstreams: 1 2013_SamanthaRo’otsitsinadeCarvalhoJuruna.pdf: 1902564 bytes, checksum: 770e5e2bf03118c9c64ca9f923cf0ee0 (MD5)
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O presente estudo teve como objetivo compreender a visão sobre o movimento indígena e as questões relativas à sustentabilidade dos parentes indígenas que participaram do IX Acampamento Terra Livre (ATL). O IX ATL ocorreu na cidade do Rio de Janeiro, entre os dias 15 e 22 de junho de 2012, como um evento paralelo a Rio +20, local onde a pesquisa foi realizada. O ATL foi uma mobilização paralela a RIO +20 e reuniu lideranças de diversos povos indígenas, as quais discutiram questões relacionadas aos direitos, educação, saúde, meio ambiente, segurança alimentar, etc. A pesquisa foi desenvolvida por meio de observação participante e entrevistas semidiretas realizadas com lideranças indígenas que participaram desse evento, as quais puderam destacar aspectos importantes sobre os temas abordados nesse estudo. As entrevistas realizadas serviram como base para elaboração de um vídeo por meio do qual alguns participantes do IX Acampamento Terra Livre expuseram seus pontos de vista e suas opiniões a respeito dos respectivos temas: ancestralidade, movimento indígena, Acampamento Terra Livre (ATL), sustentabilidade e as perspectivas para as futuras gerações. Os indígenas entrevistados no vídeo foram selecionados de acordo com a sua atuação e papel desempenhados no movimento indígena, alguns já com experiências em grandes mobilizações nacionais e outros que estavam participando pela primeira vez de um evento nacional. Sendo 16 indígenas entrevistados, de distintas regiões do país, de diversas faixas etárias e de ambos os sexos. A reflexão que se desenvolveu neste estudo fundamentou-se através dos depoimentos dos entrevistados, que colocaram a reflexão sobre sustentabilidade para os povos indígenas em preocupação para salvação do planeta, tendo como suporte os saberes tradicionais, a valorização e o fortalecimento das transmissões dos conhecimentos tradicionais, por meio da manutenção da cultura, e podendo ter outros entendimentos sobre estes temas diante da diversidade cultural dos povos indígenas. _______________________________________________________________________________________ ABSTRACT
The present study aimed to understand the vision of the indigenous movement and the issues of sustainability of indigenous relatives who participated in the IX Free Land Camp (ATL). The ATL IX occurred in the city of Rio de Janeiro, between 15 and 22 Jun 2012, as a parallel event to Rio +20, where the research was conducted. The ATL was parallel mobilization RIO +20 and met leaders of various indigenous peoples, which discussed issues related to rights, education, health, environment, food safety, etc. The research was conducted through participant observation and interviews conducted with semi direct indigenous leaders who participated in this event, which could highlight important aspects of the topics addressed in this study. The interviews served as the basis for developing a video whereby some participants in the Free Land Camp IX exhibited their views and their opinions about their themes: ancestry, indigenous movement, Free Land Camp (ATL), and sustainability the prospects for future generations. Indigenous people interviewed in the video were selected according to their performance and role played in the indigenous movement, some with experience in large national mobilizations and others who were participating for the first time a national event. Which 16 indigenous respondents from different regions of the country, of different ages and of both sexes. The reflection that developed in this study was based on the statements by the interviewees, who put reflection on sustainability for indigenous peoples in concern for saving the planet, supported traditional knowledge, appreciation and strengthening of the transmission of traditional knowledge, by maintaining the culture, and may have other understandings on these issues before the cultural diversity of indigenous peoples.
22
Lammert, Eckhard, Vincent Laudet, Michael Schubert, Kathrin Regener, Boris Strilic e Tomas Kucera. "Ancestral vascular lumen formation via basal cell surfaces". PLOS one, 2009. https://tud.qucosa.de/id/qucosa%3A28997.
Testo completoAbstract (sommario):
The cardiovascular system of bilaterians developed from a common ancestor. However, no endothelial cells exist in invertebrates demonstrating that primitive cardiovascular tubes do not require this vertebrate-specific cell type in order to form. This raises the question of how cardiovascular tubes form in invertebrates? Here we discovered that in the invertebrate cephalochordate amphioxus, the basement membranes of endoderm and mesoderm line the lumen of the major vessels, namely aorta and heart. During amphioxus development a laminin-containing extracellular matrix (ECM) was found to fill the space between the basal cell surfaces of endoderm and mesoderm along their anterior-posterior (A-P) axes. Blood cells appear in this ECM-filled tubular space, coincident with the development of a vascular lumen. To get insight into the underlying cellular mechanism, we induced vessels in vitro with a cell polarity similar to the vessels of amphioxus. We show that basal cell surfaces can form a vascular lumen filled with ECM, and that phagocytotic blood cells can clear this luminal ECM to generate a patent vascular lumen. Therefore, our experiments suggest a mechanism of blood vessel formation via basal cell surfaces in amphioxus and possibly in other invertebrates that do not have any endothelial cells. In addition, a comparison between amphioxus and mouse shows that endothelial cells physically separate the basement membranes from the vascular lumen, suggesting that endothelial cells create cardiovascular tubes with a cell polarity of epithelial tubes in vertebrates and mammals.
23
Kebe, Ndeye Mathy. "Etude du protéasome "ancestral" HslVU de Leishmania major". Thesis, Montpellier 1, 2012. http://www.theses.fr/2012MON13517/document.
Testo completoAbstract (sommario):
HslVU est une protéase dépendante de l'ATP découverte initialement chez certaines bactéries, et considérée comme une forme ancestrale du protéasome. Elle est constituée par l'association de deux sous-complexes : la protéase HslV, formée elle-même de deux anneaux hexamériques de la sous-unité HslV, et l'ATPase HslU, un hexamère de la sous-unité HslU, qui active l'activité peptidasique de HslV en s'associant à l'une ou à ses deux extrémités. HslVU a été identifiée dans la mitochondrie de protozoaires parasites, dont ceux de la famille des trypanosomatidae comme Leishmania major (agent de la leishmaniose) et Trypanosoma brucei (agent de la maladie du sommeil). Différents travaux ont montré que, chez T. brucei, l'inactivation d'HslVU par interférence ARN conduit à l'arrêt de la division cellulaire et à la mort du parasite. Puisqu'elle est absente chez l'homme, HslVU constitue donc une cible thérapeutique potentielle intéressante pour lutter contre ces parasites. Dans le cadre d'un projet collaboratif, le but de ma thèse était de caractériser la protéase HslVU de Leishmania major (LmHslVU), et de tester l'intérêt d'exploiter la symétrie de HslV pour développer des inhibiteurs empêchant la formation du complexe HslVU en se fixant à l'interface HslV/HslU. Dans ce contexte, ma thèse s'est développée autour de 3 axes principaux : (i) Production et caractérisation biochimique de LmHslV recombinant. J'ai montré que le complexe LmHslV seul est inactif, contrairement à son homologue bactérien qui a une activité basale même sans HslU, et qu'il peut être activé par des peptides synthétiques correspondant à l'extrémité C-terminale de son régulateur HslU, comme HslV d'E.coli et d'H.influenzae. Cela m'a permis de développer un test de l'activité peptidasique de LmHslV in vitro, miniaturisable pour un futur criblage de banques de molécules chimiques. La protéase LmHslV a également été caractérisée en testant l'effet de différents inhibiteurs de protéases sur son activité. Ce travail m'a également permis de montrer que l'activité peptidasique de HslV est très sensible à la présence d'ions Mg2+ dans les tampons d'activité, ce qui suggère qu'il existe des régulations allostériques des sites actifs de la protéase. (ii) Exploiter la symétrie de HslV pour développer des interacteurs multivalents de HslV. Nous avons cherché à vérifier expérimentalement si le fait d'utiliser des molécules multivalentes, c'est à dire possédant plusieurs sites d'interaction à HslV, permettait d'augmenter sensiblement l'affinité de ces molécules. Une molécule pentamérique, le « peptabody », capable de se fixer sur LmHslV via cinq sites d'interaction potentiels et agissant comme un inhibiteur de l'activité peptidasique de HslV, a été développée.(iii) Caractérisation du mode d'activation de LmHslV. Nous avons réalisé en collaboration des expériences de microscopie électronique sur LmHslV, qui ont révélé une possible rotation des deux anneaux de LmHslV liée à l'activation de la protéase. Cette rotation est spécifique de LmHslV puisqu'on ne l'observe pas chez HslV d'E. coli. La confirmation de ces résultats encore préliminaires est en coursHslVU is an ATP-dependent protease initially discovered in certain bacteria, and considered as a proteasome ancestor. It is formed by assembly of two subcomplexes: the HslV protease, itself resulting from the assembly of two hexameric rings of the HslV subunit, and the HslU ATPase, an hexamer of the HslU subunit that activates HslV upon binding.HslVU has been identified within the mitochondrion of protozoan parasites, including the Trypanosomatids Leishmania major (leishmaniasis) and Trypanosoma brucei (sleeping sickness). Different results have shown that inactivation by siRNA of HslVU leads in T. brucei to growth arrest and cell death. Since HslVU is absent in human, it thus represents an attractive drug target for the fight against these parasites. In the frame of a collaborative project, the objective of my thesis was to characterize the HslVU protease of Leishmania major (LmHslVU) and to assess the interest of exploiting HslV symmetry to develop inhibitory molecules that would block the formation of the HslVU complex by binding at the HslV/HslU interface.In this context, I studied three main issues during my PhD thesis:(i) Production and biochemical characterization of recombinant LmHslV: I could show that the HslV complex alone is inactive, contrary to its bacterial homolog which has a basal activity even in the absence of HslU, and that, as E. coli HslV, it can be activated by synthetic peptides corresponding to the C-terminal end of HslU. This work allowed me to develop an in vitro assay of HslV peptidase activity, that can be miniaturized for future screenings of chemical libraries. The active site of the LmHslV protease has also been characterized by testing the effect of different protease inhibitors on the peptidase activity. During this work, I could show that LmHslV activity is sensitive to Mg2+ ions in the activity buffers, suggesting the existence of allosteric regulations of the active sites.(ii) To exploit HslV symmetry to develop multivalent interactors of HslV. Our goal was to experimentally verify whether the use of multivalent molecules, i.e. molecules with several interaction sites to HslV, could help to develop high affinity inhibitors. A pentameric molecule, called the “peptabody”, able to bind to HslV via five interaction sites and acting as a strong inhibitor of HslV, has been developed.(iii) Characterization of the mode of activation of HslV. We performed through a collaboration electronic miscroscopy analyses of LmHslV, which revealed that the activation of the protease could be linked to a possible rotation of its two rings. Such rotation was not seen with E. coli HslV, suggesting that it is a mechanism specific of LmHslV. Study are ongoing to confirm these results
24
Yeung, Chun-kit Kevin. "Stone column bases in ancestral halls in Hong Kong". Thesis, Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B3147696X.
Testo completo
25
Topper, Ryan. "Ancestral trauma, animist poetics : African literature's regenerative death drive". Thesis, University of Leeds, 2017. http://etheses.whiterose.ac.uk/19273/.
Testo completoAbstract (sommario):
In this thesis I ask, what kind of trauma theory is immanent to modern African literature? Informed by psychoanalysis and deconstruction, I explicate from African texts a form of collective trauma that I term ancestral trauma and a regenerative logic of survival that I term animist poetics. Ancestral trauma names the process through which colonial modernity ruptures the cosmological frame of reference upon which the cultural memory of a colonized people depends. Desecrating the very form of intergenerational remembrance, ancestral trauma operates beyond the purveyance of memory studies. So does animist poetics. Rather than representing traumatic memory, animist poetics regenerates desecrated ancestral ties by paradoxically ritualizing their erasure. Animist poetics is thus an aesthetic logic immanent to modernity, which challenges dichotomies between African animism and Western modernity. Operating beyond the therapeutic framework of recovery and the Manichaeism of postcolonial critique, animist poetics reinvents precolonial cosmologies as responses to colonized modernity—not historic redemption, but collective survival. Authors such as Yvonne Vera and Wole Soyinka craft such a survival by aesthetically ritualizing death, which leads to a new theory of the death drive. Freud’s theory equates death with ontological stasis, but Vera and Soyinka posit an animist revision in which the deaths enforced by colonial and postcolonial regimes become transitions into new forms of collective life. This regenerative death drive at the heart of animist poetics both extends and overturns Freud’s most radical insight. Thus, in this thesis, through offering a postcolonial trauma theory, I ultimately gesture toward a post-secular theory of time in which the living, the dead, and the unborn can, in response to an erasure of the past, inherit the possibility of a future.
26
Minichiello, Mark Joseph. "Analysis of genetic variation data using ancestral recombination graphs". Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.613255.
Testo completo
27
Harshman, Kalli Carina, e Kalli Carina Harshman. "Preservation of Ancestral Cultivation Systems of Taro (Colocasia Esculenta)". Thesis, The University of Arizona, 2016. http://hdl.handle.net/10150/621923.
Testo completoAbstract (sommario):
Culture loss has been a causative factor of many forms of disease in indigenous populations. Ancestral growing systems and the culturally important plants propagated within the systems are included in the cultural symbols that have been diminished due to a change of power. In Hawai’i and on Easter Island, also known as Rapa Nui, these ancestral growing systems are the lo’i and the manavai respectively. The symbolic plant is taro (Colocasia esculenta). Currently the systems are being revived at different rates, and with the revival of the systems, there is a higher potential for well-being. Well-being is analyzed in the realms of the individual, the relational, and the collective. The community built surrounding the redevelopment of the lo’i and the manavai addresses each level of well-being.
28
Galdós, Rodríguez Guillermo. "Guaneras de Kuntisuyu : su ancestral y multiétnica posesión prehispánica". Pontificia Universidad Católica del Perú, 2014. http://repositorio.pucp.edu.pe/index/handle/123456789/114404.
Testo completo
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Bejarano, Villarroel Julio Alejandro. "Espaço Andino : Chipaya, uma lógica ancestral de conformação urbana". reponame:Repositório Institucional da UnB, 2008. http://repositorio.unb.br/handle/10482/1323.
Testo completoAbstract (sommario):
Dissertação (mestrado)—Universidade de Brasília, Faculdade de Arquitetura e Urbanismo, 2008.Submitted by Jaqueline Oliveira (jaqueoliveiram@gmail.com) on 2008-12-15T15:11:32Z No. of bitstreams: 1 DISSERTACAO_2008_JulioAlejandroBejaranoVillarroel.pdf: 2065118 bytes, checksum: 85d9e298ab5a56ca3af5f47027706b8a (MD5)
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Made available in DSpace on 2009-02-20T14:31:07Z (GMT). No. of bitstreams: 1 DISSERTACAO_2008_JulioAlejandroBejaranoVillarroel.pdf: 2065118 bytes, checksum: 85d9e298ab5a56ca3af5f47027706b8a (MD5)
Este estudo pretende levar o leitor a uma maior compreensão sobre o Espaço Andino. Em principal, observando as suas características particulares de estruturação espacial. Neste sentido, a análise toma como objeto central a comunidade indígena Chipaya, localizada na região andina da Bolívia. Considerando que este povo antigamente ostentava traços próprios na concepção, configuração e manejo de seu espaço. E sendo, no transcorrer do tempo, influenciado por múltiplas adequações em seu esquema urbano e forma de vida, sobretudo a partir do período colonial espanhol. Ainda hoje, se observa nesta comunidade uma essência importante na organização de seu espaço, dentro de uma visão de mundo andino que sempre foi refletida sobre esta região. Aspectos estes, que formam parte da análise que aborda o presente estudo. Pretende-se, que este conhecimento possa levar o leitor a uma reflexão mais ampla sobre este tema, a partir da formação que compete, principalmente como arquitetos, urbanistas ou simples pessoas interessadas no problema. Estabelecendo entre eles um devido conhecimento e nisso o respeito ao pensamento e à forma de vida das comunidades indígenas nesta zona.
This study intends to lead the reader to a greater comprehension of the Andean Space. In principal, observing the main characteristics of spatial structuring. In this sense, the analysis takes as central object the indigenous community Chipaya, located in the Andean region of Bolivia. Considering the fact that this people formerly held their own traces in the conception, configuration, and handling of their space. And, in the time passing, being influenced by multiple adequacies in its urban scheme and way of living, mostly from the Spanish colonial period. Still today, an important essence in the organization of its space is observed in this community in a view of the Andean world that was always reflected on this region. These are the aspects that form part of the analysis that addresses the present study. The intention of the study is that this knowledge should lead the reader, starting from our own knowledge, in special, as architects, urbanists or simple people interested in the problem, to a broader reflection of the theme. Setting among them the appropriate knowledge for the thought and the way of living of the indigenous communities in this zone.
Este estudio pretende llevar al lector a una mayor comprensión sobre el Espacio Andino. Principalmente, observando sus características particulares de estructuración espacial. En este sentido, el análisis toma como objeto central a la comunidad indígena Chipaya, localizada en la región andina de Bolivia. Considerando que este pueblo antiguamente ostentaba trazos propios en la concepción, configuración y manejo de su espacio. Siendo influenciado en el transcurrir del tiempo, por múltiples adecuaciones en su esquema urbano y forma de vida, sobre todo a partir del periodo colonial español. Aun hoy, se observa en esta comunidad una esencia importante en la organización de su espacio, dentro de una visión de mundo andino que siempre fue reflejada sobre esta región. Aspectos estos, que forman parte del análisis que aborda el presente estudio. Se pretende, que este conocimiento pueda llevar al lector a una reflexión más amplia sobre este tema, a partir de la formación que compete, principalmente como arquitectos, urbanistas o simples personas interesadas en este problema. Estableciendo en estos un debido conocimiento y en eso el respeto al pensamiento y la forma de vida de las comunidades indígenas en esta zona.
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Bales, Ashley. "The phylogenetic position of Proconsul and catarrhine ancestral morphotypes". Thesis, New York University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10192021.
Testo completoAbstract (sommario):
There continues to be a lack of agreement concerning the precise phylogenetic placement of Proconsul despite the wealth of fossil material and the extensiveness of its study. The difficulty in resolving the phylogenetic status of this important and well represented Miocene catarrhine is a consequence of its apparent basal position relative to crown catarrhines. This position complicates the inference of character polarities. This dissertation tests three previously proposed hypotheses concerning the phylogenetic position of Proconsul: (1) Proconsul is a stem catarrhine; (2) Proconsul is a stem hominoid; and (3) Proconsul is a basal hominid, most closely related to extant great apes and humans. A phylogenetic analysis based on 719 characters drawn from the skull, forelimb, pelvis and foot, and sampling a diversity of extant anthropoid taxa, offers no compelling support for a hominoid clade that includes Proconsul. The radiation of crown catarrhines involved rapid evolutionary changes from the ancestral catarrhine morphotype, resulting in stem catarrhines appearing much more similar to each other, even where there are key synapomorphies linking them with crown clades. As a result, systematic analyses alone are insufficient to confidently support a single optimal phylogenetic hypothesis. Further exploration of the data, by combining inferred ancestral morphotypes with phenetic visualizations of character evolution, demonstrated that inclusion of Proconsul among Hominoidea or Hominidae pushed the ancestral catarrhine morphotype closer to these clades, respectively. Given a more comprehensive analysis of character evolution under each hypothesis, this dissertation supports the hypothesis that Proconsul is a stem catarrhine. In addition to helping clarify the long-running debate about the phylogenetic status of Proconsul, the results offer fresh insights into the early stages of hominoid evolution and demonstrate the importance of comprehensive phylogenetic analyses in helping to resolve the relationships of problematic stem taxa.
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Morphy, Howard. "Ancestral connections : art and an aboriginal system of knowledge /". Chicago : University of Chicago press, 1991. http://catalogue.bnf.fr/ark:/12148/cb356879823.
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Larribe, Fabrice. "Cartographie génétique fine par le graphe de recombinaison ancestral /". [Montréal] : Université de Montréal, 2003. http://wwwlib.umi.com/cr/umontreal/fullcit?pNQ92722.
Testo completoAbstract (sommario):
Thèse (Ph.D.) -- Université de Montréal, 2004."Thèse présentée à la Faculté des études supérieures en vue de l'obtention du grade de Philosophiae Doctor (Ph.D.) en Statistique" Version électronique également disponible sur Internet.
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Lyons, Patrick Daniel. "Winslow Orange Ware and the ancestral Hopi migration horizon". Diss., The University of Arizona, 2001. http://hdl.handle.net/10150/280552.
Testo completoAbstract (sommario):
This project involved instrumental neutron activation analysis of 428 ceramic vessels and clays, typological analysis of 1135 vessels, and stylistic analysis of more than 400 bowls. Most of the items analyzed were recovered from the Homol'ovi villages, a group of eight Pueblo III--Pueblo IV (circa A.D. 1250--1400) sites located near Winslow, Arizona. These studies were conducted in order to address the question of the origin(s), geographically speaking, of the ancient inhabitants of the Homol'ovi villages. The results of the compositional analysis indicate local production of Winslow Orange Ware at Homol'ovi and in the Petrified Forest. Circulation of Winslow Orange Ware to the Anderson Mesa area, the Tonto Basin, and the Verde Valley is also evident. Furthermore, among the earliest ceramic assemblages from the Homol'ovi sites were found locally-produced versions of ancestral Hopi pottery types and vessel forms. The compositional data also point to local production of Roosevelt Red Ware at Homol'ovi and in the Petrified Forest. The whole vessel study resulted in the observation that most Winslow Orange Ware vessels represent attempts to produce Jeddito Orange Ware using materials indigenous to the Middle Little Colorado River Valley. An examination of the dating and distribution of different kiva forms revealed that Homol'ovi ceremonial architecture reflects western Kayenta and Tusayan patterns, supporting the ceramic-based inference of ancestral Hopi migration. Placing these results in broader context, it is possible to discern an ancestral Hopi migration horizon which corresponds with what has been called the Salado archaeological culture or the "Salado phenomenon." By examining Hopi oral texts, it was observed that many include information that correlates with archaeological and anthropological models of Hopi origins. By hypothesizing that these accounts represent significantly restructured texts, it is possible to resolve apparent disconformities between Hopi oral tradition and anthropological inferences. This conception of Hopi migration accounts allows resolution of conflicting interpretations of Homol'ovi, i.e., the idea that it is an ancestral Hopi place because its inhabitants moved to the Hopi Mesas circa A.D. 1400, versus the notion that it is an ancestral Hopi place because its inhabitants were immigrants from the Hopi Mesas.
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Al-Nuaimi, Bashar. "Ancestral Reconstruction and Investigations of Genomics Recombination on Chloroplasts Genomes". Thesis, Bourgogne Franche-Comté, 2017. http://www.theses.fr/2017UBFCD042/document.
Testo completoAbstract (sommario):
La théorie de l’évolution repose sur la biologie moderne. Toutes les nouvelles espèces émergent d’une espèce existante. Il en résulte que différentes espèces partagent une ascendance commune, telle que représentée dans la classification phylogénétique. L’ascendance commune peut expliquer les similitudes entre tous les organismes vivants, tels que la chimie générale, la structure cellulaire, l’ADN comme matériau génétique et le code génétique. Les individus d’une espèce partagent les mêmes gènes mais (d’ordinaire) différentes séquences d’allèles de ces gènes. Un individu hérite des allèles de leur ascendance ou de leurs parents. Le but des études phylogénétiques est d’analyser les changements qui se produisent dans différents organismes pendant l’évolution en identifiant les relations entre les séquences génomiques et en déterminant les séquences ancestrales et leurs descendants. Une étude de phylogénie peut également estimer le temps de divergence entre les groupes d’organismes qui partagent un ancêtre commun. Les arbres phylogénétiques sont utiles dans les domaines de la biologie, comme la bio informatique, pour une phylogénétique systématique et comparative. L’arbre évolutif ou l’arbre phylogénétique est une exposition ramifiée les relations évolutives entre divers organismes biologiques ou autre existence en fonction des différences et des similitudes dans leurs caractéristiques génétiques. Les arbres phylogénétiques sont construits à partir de données moléculaires comme les séquences d’ADN et les séquences de protéines. Dans un arbre phylogénétique, les nœuds représentent des séquences génomiques et s’appellent des unités taxonomiques. Chaque branche relie deux nœuds adjacents. Chaque séquence similaire sera un voisin sur les branches extérieures, et une branche interne commune les reliera à un ancêtre commun. Les branches internes sont appelées unités taxonomiques hypothétiques. Ainsi, les unités taxonomiques réunies dans l’arbre impliquent d’être descendues d’un ancêtre commun. Notre recherche réalisée dans cette dissertation met l’accent sur l’amélioration des prototypes évolutifs appropriés et des algorithmes robustes pour résoudre les problèmes d’inférence phylogénétiques et ancestrales sur l’ordre des gènes et les données ADN dans l’évolution du génome complet, ainsi que leurs applications.[...]The theory of evolution is based on modern biology. All new species emerge of an existing species. As a result, different species share common ancestry,as represented in the phylogenetic classification. Common ancestry may explainthe similarities between all living organisms, such as general chemistry, cell structure,DNA as genetic material and genetic code. Individuals of one species share the same genes but (usually) different allele sequences of these genes. An individual inheritsalleles of their ancestry or their parents. The goal of phylogenetic studies is to analyzethe changes that occur in different organisms during evolution by identifying therelationships between genomic sequences and determining the ancestral sequences and theirdescendants. A phylogeny study can also estimate the time of divergence betweengroups of organisms that share a common ancestor. Phylogenetic trees are usefulin the fields of biology, such as bioinformatics, for systematic phylogeneticsand comparative. The evolutionary tree or the phylogenetic tree is a branched exposure the relationsevolutionary between various biological organisms or other existence depending on the differences andsimilarities in their genetic characteristics. Phylogenetic trees are built infrom molecular data such as DNA sequences and protein sequences. Ina phylogenetic tree, the nodes represent genomic sequences and are calledtaxonomic units. Each branch connects two adjacent nodes. Each similar sequencewill be a neighbor on the outer branches, and a common internal branch will link them to acommon ancestor. Internal branches are called hypothetical taxonomic units. Thus,Taxonomic units gathered in the tree involve being descended from a common ancestor. Ourresearch conducted in this dissertation focuses on improving evolutionary prototypesappropriate and robust algorithms to solve phylogenetic inference problems andancestral information about the order of genes and DNA data in the evolution of the complete genome, as well astheir applications
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Purcell, Marisa. "Ancestral Spaces: Time, Memory and the Liminal Experience of Painting". University of Sydney, 2008. http://hdl.handle.net/2123/2763.
Testo completoAbstract (sommario):
Master of Visual ArtsAbstract of Dissertation Where a person is situated in space and time determines the way an artwork is perceived. The result of this experience implies a relationship between the viewer and the artwork, thereby creating a liminal space. The terms liminal space and nonduality in this paper refer to the threshold, or in-between space that both separates and unites two opposing forces, creating a unique place that transcends memory and time. An artwork can serve as a mediatory object between artist and viewer because with each encounter, a unique meeting occurs. Thus, the meeting of audience and art object is transitory, ephemeral and temporal by nature and will be discussed in relation to the artwork as a vehicle to foster a subjective perception. Using my ancestral memories as a starting point, I refer to the art object as a means to explore time as a cross section of experience. Like dreams, where time is non-linear and memories exist side by side, I refer to the nondual space that exists between artist, artwork and audience as an opportunity to access an intuitive reaction to perception. The yearning to represent subjective space stems from my desire to understand perception and the brain. By presenting an overview of approaches from art history and contemporary art, this paper will discuss the various philosophical approaches that have been employed to represent space and time. I emphasise the ability of visual art to record the multifarious nature of experience, and the ability of the picture plane as a means to employ illusory and abstract space simultaneously. I have approached the research of time, memory and space through the lens of my own ancestry, which is essentially a combination of eastern and western in origin. Through this model I explore the tendencies throughout art history to depict space and time and the influences that culture and science have had upon the visual arts. My own paintings, and the work of Louise Bourgeois, Amy Cutler and Mamma Andersson are discussed with the intention of describing how the subjectivity of space can be expressed through a method that embraces the theories of nonduality and liminal space. Between the junction of east/west and abstract/illusory space, lies a point of union that I will refer to as ‘transcendent space’. By existing in the nondual, access is granted into a field that transcends the ‘either/or’ and allows access into a temporal space that permeates all experience. Studio work The studio component of the MVA will comprise of a series of paintings and an installation entitled, Only the memories are new. The paintings are of small scale and play with depictions of flatness and illusion. I have referenced Arabic miniatures as a means to employ a vertical perspective, whilst the inclusion of windows and doorways imply an opening to the nondual and the liminal. For the installation, components of the paintings come to life and occupy a space that invites the viewers’ participation. The installation presents an environment that asks the viewer to navigate the space that they occupy by way of memory and time.
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Maraire, Dumisani. "The position of music in Shona mudzimu (ancestral spirit) possession /". Thesis, Connect to this title online; UW restricted, 1990. http://hdl.handle.net/1773/11274.
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Webster, Andrea Jane. "Ancestral body size and the evolutionary ecology of phyletic dwarfs". Thesis, Imperial College London, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421950.
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Crouch, Daniel. "Inferring ancestral and biogeographic origin using genome-wide SNP data". Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/inferring-ancestral-and-biogeographic-origin-using-genomewide-snp-data(e08f9863-9d91-48d2-a50f-f3fbee6269f1).html.
Testo completoAbstract (sommario):
Statistically predicting the origin of a human DNA sample has proven effective in forensic casework, and is of broad population genetic interest, but many facets of the problem remain unexplored. This thesis consolidates several pieces of work on the genetic prediction of origin; furthering its theory and practice. I begin by examining the performance of straightforward predictive methods when the objective is to correctly determine an individual's origin from one of several closely related genetic groups, e.g. countries within Europe. Of particular interest are the volume of data required to make useful predictions, and the negative impact of combining data from independently collected convenience samples. Depending on these factors, I show that it is possible to predict origin from either Great Britain or Ireland with good accuracy. The same approach was applied to a unique dataset, provided by Dr. Jim Wilson and colleagues, in which individuals were ascertained based on their self-reported village of origin from sets of neighbouring villages. Highly accurate predictions for village of origin were attained, demonstrating the detailed geographic resolution at which this branch of statistical methodology may succeed. Origin has innumerable aspects, many of which may be tractable to genetic prediction. Two in particular are the topics of consideration throughout the remainder of the thesis. First, I develop models for predicting separate ancestral components in each parent of a genotyped 'target' individual (Crouch and Weale, 2012), providing a more detailed profile than models of lone personal ancestry. Accuracy is high when genome-wide data are available and the modelled populations are relatively genetically dissimilar e.g. West Africa, Europe and East Asia. Second, I develop a method for predicting geographic coordinates for target individuals, constituting an estimate of their biogeographic origin in continuous space, and compare performance within Europe against existing approaches. While one alternative (Hoggart et al., 2012) displayed greater accuracy, the merits of each method are discussed in full.
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Moraes, Josenice Regina Blumenthal de. "Ser herdeiro de um ancestral que construiu um legado empresarial". Pontifícia Universidade Católica de São Paulo, 2011. https://tede2.pucsp.br/handle/handle/15000.
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Made available in DSpace on 2016-04-28T20:37:35Z (GMT). No. of bitstreams: 1
Josenice Regina Blumenthal de Moraes.pdf: 951545 bytes, checksum: 2d936c3060acb6964b736fd6af060cb9 (MD5)
Previous issue date: 2011-05-10Within family business literature, there are currently many issues about succession, the heirs´ skills and, consequently, about the hopes of their long term survival. The realm of these issues is the main justification for this dissertation, which first considered the ensuing research question: are the heirs in family businesses heard? Following this primary research question, the main objective of this dissertation was developed: to comprehend what it means to be the heir of an ancestor that has built up and left behind a business legacy, and how this fact influences the subject´s life; and, more specifically, try to identify in which ways the heirs life is affected based on the subjects own perceptions about this process. In order to achieve these objectives, a qualitative investigation was carried out with an instrumental case study design grounded in the Systemic Approach of the family and in the Three- Dimensional Model of Family Business Development - which tries to differentiate family relationships from the business context. The analysis was also grounded in the Intergenerational Approach, when dealing with legacy and delegations aspects. The subjects of this research were three heirs that were asked by the researcher herself to join this study. Data was drawn from the recordings of semi-structured interviews carried out with the participants, and also from the following instruments applied: the Constructivist Genogram and the Family Time-Line. Preceding individual data analysis, the analysis was first broadly conducted so to, later on, identify differences and similarities amongst the cases. The results reported individual differences concerning the participants unique life stories and similarities that are constituent of the heir-phenomenon and its influences in their life, which in turn, can be generalized. This dissertation points out paths for further in-depth scientific research, specifically in Brazilian academia, that can help provide further comprehension of the heir-phenomenon within our country s peculiarities
Atualmente existem preocupações a respeito da sucessão dentro de empresas familiares, competências dos herdeiros, e consequentemente, com as expectativas de sua preservação. Essas preocupações justificam a realização desta dissertação considerando a seguinte inquietação: seriam esses herdeiros ouvidos? A partir dessa questão estabeleceu-se seu objetivo geral: compreender como ser herdeiro de um ancestral que construiu um legado empresarial influencia a vida do sujeito, e, especificamente, identificar de que forma a vida desse herdeiro é influenciada, baseando-se em suas percepções sobre esse processo. Para alcançar esses objetivos realizou-se uma investigação qualitativa, com delineamento de estudo de caso instrumental e coletivo fundamentado na Abordagem Sistêmica da família, e no Modelo Tridimensional de Desenvolvimento da Empresa Familiar, que procura diferenciar as relações familiares do contexto da empresa. A compreensão do ser herdeiro também foi tratada sob o enfoque da Abordagem Intergeracional, quanto aos aspectos do que se é legado e do que se delega. Foram sujeitos dessa pesquisa três herdeiros convidados pela pesquisadora. Os dados apresentados originaram-se dos registros de entrevistas semi-estruturadas com os participantes, bem como dos instrumentos aplicados: o Genograma Construtivista e a Linha de Tempo Familiar. Procedeu-se à análise individual dos dados a seguir, de forma coletiva e, posteriormente buscaram-se as diferenças e similitudes entre os casos. Os resultados assinalaram diferenças individuais concernentes à história de vida de cada participante, e similitudes que constituem o fenômeno de ser herdeiro e de suas influências em suas vidas, as quais podem ser generalizadas. Esse estudo apontou para a possibilidade de aprofundamentos teóricos sobre a temática, no meio acadêmico brasileiro, por meio de pesquisas científicas, que venham a auxiliar a compreender o fenômeno do ser herdeiro dentro das peculiaridades de nosso país
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Tessier, Christian. "Dissecting Kinetic Differences in Acetylcholine Receptors Incorporating an Ancestral Subunit". Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/38868.
Testo completoAbstract (sommario):
At the neuromuscular junction, nicotinic acetylcholine receptors (AChRs) convert chemical stimuli into electrical signals. They are heteropentameric membrane protein complexes assembled from four evolutionary related subunits (two α subunits, and one each of the β-, δ-, and ε-subunits), arranged around a central ion-conducting pore, which is regulated by the neurotransmitter acetylcholine. Understanding how the binding of acetylcholine leads to channel opening is of fundamental importance. While it is known that channel opening results from a global conformational change involving the cooperative action of all five subunits, how the subunits achieve this cooperativity is unclear. Our hypothesis is that this subunit cooperation is maintained through coevolution of the subunits, and thus studies of subunit coevolution can provide insight into subunit cooperativity. Using an ancestral reconstruction approach, combined with single-molecule patch clamp electrophysiology, we have begun dissecting the mechanistic consequences of preventing coevolution of the acetylcholine receptor β-subunit. This approach has allowed us to identify new amino acid determinants of acetylcholine receptor function.
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Fan, Hang. "Species Tree Likelihood Computation Given SNP Data Using Ancestral Configurations". The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385995244.
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Purcell, Marisa. "Ancestral spaces time, memory and the liminal experience of painting /". Connect to full text, 2007. http://hdl.handle.net/2123/2763.
Testo completoAbstract (sommario):
Thesis (M.V.A.)--University of Sydney, 2008.Title from title screen (viewed 11 September, 2008). Submitted in fulfilment of the requirements for the degree of Master of Visual Arts to the Sydney College of the Arts. Degree awarded 2008; thesis submitted 2007. Includes bibliographical references.
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Cutright-Smith, Elisabeth. "Modeling Ancestral Hopi Agricultural Landscapes: Applying Ethnography to Archaeological Interpretations". Thesis, The University of Arizona, 2007. http://hdl.handle.net/10150/193274.
Testo completoAbstract (sommario):
In this thesis, historic Hopi ethnographic data are employed to model ancestral Hopi agricultural land use through the lens of archaeological landscape theory. Emphasizing the interconnectedness of landmarks--loci of discrete interactions between humans and the land--within networked cultural landscapes, archaeological landscape theory provides a unique perspective from which to examine overlapping planes of historic and prehistoric land use.Drawing on ethnographic accounts, a model is constructed that integrates the physical, social organizational, ritual/ceremonial, and traditional history dimensions of historic Hopi agricultural land use. Durable material correlates of agricultural land use are proposed on the basis of ethnographic documentation. This holistic model is applied to archaeological data from the Homol'ovi Ruins State Park (HRSP), northeastern Arizona. The integrative model produced herein allows for the interpretation of relationships between archaeological features representing different land use behaviors and the conceptualization of linkages between landmarks in the ancestral Hopi agricultural landscape.
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Beetson, Alethea A. "Always was, always will be: Continuing ancestral connectivity through performance". Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/228636/1/Alethea_Beetson_Thesis.pdf.
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Yanez, Jonathan Xavier Andrade. "O nativo-experimental: música experimental e seus contatos com a cosmologia nativo-ancestral da América do Sul". Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/27/27158/tde-22092016-134017/.
Testo completoAbstract (sommario):
A dissertação procura compreender os acontecimentos musicais derivados do contato da denominada Música Experimental com realidades musicais Nativo Ancestrais Indígenas do continente sul-americano. Para isso, realiza uma contextualização histórica da evolução do experimentalismo musical desde 1950, seguindo um percurso linear até a atualidade, onde se destacam trabalhos e pesquisas de compositores ativos, que têm abordado especificamente as relações entre música, cosmovisão indígena e o xamanismo dentro do processo de experimentação sonoro/musical. Nesse contexto, se evidencia a criação de relações transculturais, produzidas entre duas realidades heterogêneas que, na contemporaneidade, se complementam. Para finalizar a presente pesquisa apresenta o trabalho prático, decorrente da criação de partituras gráficas e instruções verbais, desenvolvidas com o grupo de pesquisa em improvisação e experimentação musical Orquestra Errante (ECA-USP), onde foram utilizados elementos conceituais e sonoro/musicais nativo-indígenas e eco-escuta em práticas regulares de improvisação livre, evidenciando as dificuldades e possíveis estratégias para a conjunção entre o nativo-natural e o experimental.The thesis seeks to understand musical events derivate from the contact of the so called Experimental Music with musical realities of Indigenous Native-Ancestry of the South American continent. To do so, it performs a historical context of the evolution of musical experimentation since 1950, following a linear path to the present, which features work and research of active composers who have specifically addressed the relationship between music, indigenous worldview and shamanism within the process of sound/musical experimentation. In this context, it highlights the creation of cross-cultural relations, produced between two heterogeneous realities that, in contemporary times, complement each other. Finally this research presents the practical work, arising from the creation of graphic scores and verbal instructions, developed with the research group in improvisation and musical experimentation Orchestra Errante (ECA-USP), where are used conceptual and sound/musical elements forma indigenous native-ancestry of South America and eco-listening in regular practices of free improvisation, highlighting the difficulties and possible strategies for the conjunction between two antagonistic elements, native-experimental.
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Feiner, Nathalie [Verfasser]. "Characterization of cryptic components of the ancestral vertebrate genome / Nathalie Feiner". Konstanz : Bibliothek der Universität Konstanz, 2013. http://d-nb.info/1035067048/34.
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Wong, Min Hoi. "A Christian perspective on Chinese ancestral practices in the United Kingdom". Thesis, Bangor University, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.543219.
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Hummel, Sebastian [Verfasser]. "Ancestral Lines in Deterministic and Stochastic Mutation-Selection Models / Sebastian Hummel". Bielefeld : Universitätsbibliothek Bielefeld, 2019. http://d-nb.info/1190817985/34.
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Straub, Kristina [Verfasser], e Rainer [Akademischer Betreuer] Merkl. "Ancestral Sequence Reconstruction: Methods and Applications / Kristina Straub ; Betreuer: Rainer Merkl". Regensburg : Universitätsbibliothek Regensburg, 2019. http://d-nb.info/1194961282/34.
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Kucewicz, Cezary Jerzy. "Ancestral custom? : the treatment of the war dead in Archaic Athens". Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10048636/.
Testo completoAbstract (sommario):
The public burial of the war dead in Classical Athens has traditionally been a subject of much scholarly interest. Although the origins of the procedures described by Thucydides as patrios nomos are still a matter of some debate, far less attention has been devoted to the Athenian war dead of the Archaic period. This thesis aims to redress this balance, looking at the practice of war burials in early Athens, through a range of evidence including mythology, archaeology and art. The thesis begins with a study of the Homeric epics, which provide our richest source for the early treatment of the war dead. The poems reveal a highly stratified society divided between the elites and the masses, where social status was strictly delineated by the postmortem fate of the fallen. Chapter 2 focuses on early Greek mythological traditions concerning burial truces and the mutilation of the dead. It is suggested that the major change implicit in these stories towards the end of the Archaic period can be aligned with wider ideological shifts in the perception of the dead in Athens and elsewhere. The iconographical and archaeological evidence forms the subject of Chapter 3, which looks at artistic depictions on vases and funerary monuments in early Athens. The fate of the war dead, it is argued, was fundamentally defined by the highly elitist mentality which influenced the contemporary practice of war. Finally, Chapter 4 sets these conclusions in the context of Athenian political history, tracing the social and institutional developments of the citizen army up to the reforms of Cleisthenes. The treatment of the war dead, it is concluded, provides important insights into the nature and composition of Archaic Athenian armies, illuminating a number of social and cultural shifts which transformed Athens towards the end of the sixth century BC.