Tesi sul tema "Alpha variation"
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Holmes, Mark D. "Molecular analyses of alpha 1-antitrypsin variation and deficiency /". Title page, table of contents and aims and general introduction only, 1992. http://web4.library.adelaide.edu.au/theses/09MD/09mdh752.pdf.
Testo completoKhan, Fayeza Fatima. "Characterization of the alpha defensin copy number variation in humans". Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12693/.
Testo completoMcKechnie, Victoria Margaret. "Variation in the NS5A gene of Hepatitis C Virus in response to interferon alpha therapy". Thesis, University of Glasgow, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301364.
Testo completoWang, Qingfeng. "Rough path properties for local time of symmetric alpha stable processes". Thesis, Loughborough University, 2012. https://dspace.lboro.ac.uk/2134/11052.
Testo completoWood, Alice Margaret. "The role of genetic and environmental variation in the respiratory phenotype of alpha 1 antitrypsin deficiency". Thesis, University of Birmingham, 2010. http://etheses.bham.ac.uk//id/eprint/764/.
Testo completoBerengut, Julian Carlo Physics Faculty of Science UNSW. "Isotope shift and relativistic shift in atomic spectra". Awarded by:University of New South Wales. Physics, 2006. http://handle.unsw.edu.au/1959.4/23900.
Testo completoGokcek, Sarac Cigdem. "Study On The Molecular Basis Of Individual Variation In Spatial Memory In Rats". Phd thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614332/index.pdf.
Testo completogood&rdquo
and &ldquo
poor&rdquo
learners belonging to a random population of young animals. In the present study, an attempt was taken to correlate the individual variation in short- and long-term spatial memory in three different lines of young, healthy rats: inbred Wistar (W), outcrossed Wistar/Spraque Dawley (W/S) and pigmented Long-Evans rats, with hippocampal levels of selected enzymes known as &ldquo
memory molecules&rdquo
including neuronal (n), endothelial (e) and inducible (i) NOS, CaMKII&alpha
, PKA and ChAT. Additionally, in order to indirectly estimate the activity of CaMKII&alpha
and PKA, hippocampal levels of their phosphorylated forms (pCaMKII&alpha
and pPKA) were assessed. Rats were classified as &ldquo
good&rdquo
and &ldquo
poor&rdquo
learners on the basis of their performance in a partially baited 12-arm radial maze. The hippocampal protein levels were measured using Western Blot technique. In addition to individual variation in animals&rsquo
learning capacity, strain-depended differences have also been observed. Deficient performance recorded in inbred W rats compared to outcrossed W/S rats, and &ldquo
poor&rdquo
learners from both rat groups had predominantly related to the higher frequency of reference memory errors. The results of biochemical assays showed strain-depended differences in the NOS expression. The overall NOS levels were significantly higher in outcrossed W/S rats compared to inbred W rats. In both rat lines, the rate of learning positively correlated with hippocampal levels of nNOS and negatively correlated with iNOS levels. Hippocampal eNOS levels correlated negatively with animals&rsquo
performance but only in the W rats. These results suggested that all 3 NOS isoforms are implemented in the learning process playing, however, different roles in neural signaling. Experiments carried out on Long-Evans rats did not reveal a significant difference in the basal hippocampal levels of the CaMKII&alpha
, however, the level of the pCaMKII&alpha
, was significantly higher in &ldquo
good&rdquo
learners. Also, hippocampal levels of both PKA and pPKA, as well as that of ChAT were significantly higher in &ldquo
good&rdquo
as compared to &ldquo
poor&rdquo
learners. Taken together, the latter findings indicate that low hippocampal expression of PKA and ChAT as well as low CaMKII&alpha
or PKA activation may cause learning deficits in random population of young rats, and thus, these enzymes can be considered target molecules when looking for cognitive enhancers to treat memory deficits in young subjects.
Böttiger, Anna. "Genetic variation in the folate receptor-alpha and methylenetetrahydrofolate reductase genes as determinants of plasma homocysteine concentrations". Doctoral thesis, Örebro universitet, Hälsoakademin, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-2625.
Testo completoŽirgulevičiūtė, Jūratė. "P-variacijos indekso vertinimo ekonometrinis tyrimas". Master's thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2008~D_20090908_201800-34444.
Testo completoTo estimate the roughness of the sample function the methodology introdused in Norvaiša and Salopek (2002) was applied. The roughness is defined as p-variation index of the sample function graph. Methodology is based on linear regression of the oscilation index. This master thesis tests the assumptions of linear regression residuals and constructs estimator which fulfill these assumptions. The model was used for the generated α-stable process and fractional Brownian motion. Conclusions are generalized using Monte-Carlo procedure. The confidence intervals for the p-variation index was constructed making assumption that the process is the realisation of -stable or fractional Brownian motion. The p-variation index was estimated for the „Vallourec” stock price data, sampled at irregular time. In addidion the variability in time of p-variation index was studied for different segments of intervals.
Matharoo, Balwir. "The Glutathione S-Transferases : a study of genetic variation and development of the alpha, mu and pi isoenzymes". Thesis, Keele University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261477.
Testo completoBozhkov, Stanislav. "Idiosyncratic risk and the cross section of stock returns". Thesis, Brunel University, 2017. http://bura.brunel.ac.uk/handle/2438/16792.
Testo completoYearley, Jennifer Holmes. "Myocardial Macrophage Phenotypic Variation and Cytokine-Mediated Induction of HIV-Associated Cardiac Disease: A Dissertation". eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/355.
Testo completoSantos, Anita Stival dos. "Efeitos de filtros ambientais nos padrões de diversidade de árvores na floresta atlântica do sul do Brasil sob uma perspectiva de metacomunidades". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/106403.
Testo completoUnderstanding patterns of species diversity and composition across multiple scales is one of the main purpose in ecology and biogeography. The relative importance of the mechanisms that structure plant communities and how they interact to influence these patterns remains a topic of hot debate. In the present study, we use data from the Forest Inventory of Santa Catarina to investigate the patterns of species diversity of subtropical Atlantic forests and its relationships with environmental heterogeneity on a metacommunity perspective (species-sorting). The key prediction of this viewpoint is that community composition varies in response to differences in environmental conditions among habitat patches. Our study focused on this perspective, aiming to understand how environmental filtering processes interact directly and indirectly on diversity patterns in an area of 95000 km 2 (data from 432 forest plots). We employed structural equation modeling (PLS Path Modeling) to disentangle the interactive effects of topography, climate, water-energy balance, and geometry of forest patches upon the alpha and beta diversity of a subtropical forest metacommunity in southern Brazil. Factors related to environmental filtering showed substantial effects upon tree alpha and beta diversity. The total amount of variation in beta diversity explained by environmental filtering was high (64%) and was even more when together with alpha diversity (73%), corroborating the prediction of species-sorting model at the metacommunity level. Climatic extremes, water-energy balance and alpha diversity were the key determinants of beta diversity and patch size and water- energy balance the key determinants of alpha diversity in the South Brazilian Atlantic forests. Partial mantel test showed that environmental effects occurred largely independent of spatial effects, reinforcing the tested prediction. Our study provides strong empirical support for the prediction that beta diversity primarily reflects deterministic factors associated with species niches and their responses to environmental conditions in the studied spatial scale.
Dong, Linda M. "Genetic variations in calcium and vitamin D related genes and colon cancer risk /". Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/10926.
Testo completoKhorsi-Cauet, Hafida. "Variabilité génétique et mécanismes moléculaires de résistance à l'interferon du virus de l'hépatite C de génotype 1b : étude de l'interaction entre les protéines NS5A et PKR". Amiens, 1999. http://www.theses.fr/1999AMIED002.
Testo completoMarion, Harold. "Contrôle des collisions froides du césium 133 : tests de la variation de la constante de structure fine à l'aide d'une fontaine atomique double rubidium-césium". Phd thesis, Université Pierre et Marie Curie - Paris VI, 2005. http://tel.archives-ouvertes.fr/tel-00008921.
Testo completoFoxx-Lupo, William T. "Influence of genetic variation of the alpha-subunit of the epithelial sodium channel (ENaC) on baseline pulmonary function and exhaled sodium ions (Na+) and chloride ions (Cl-) in healthy subjects and patients with cystic fibrosis". The University of Arizona, 2012. http://hdl.handle.net/10150/623609.
Testo completoSpecific Aims: The epithelial sodium channels (ENaC) found on the apical membranes of epithelial cells including those lining the respiratory tract are the rate limiting step of the absorption of excess fluid from the airspace of the alveoli. ENaC function is modulated by the effects of various physiologic signals such as the adrenergic and purinergic pathways, in addition to other local channels which control the flow of negatively charged ions such as the cystic fibrosis transmembrane conductance regulator (CFTR). We sought to determine the influence of genetic variation on the alpha subunit of ENaC at amino acid position 663 on baseline exhaled ions and pulmonary function in patients with CF. Methods: We assessed pulmonary function ( forced vital capacity[FVC], forced expiratory volume in one second [FEV1], forced expiratory flow maximum[FEFmax]) using a Medical Graphics cardiopulmonary testing device (Minneapolis, MN). Measures of exhaled sodium (Na+) and chloride (Cl-) were obtained using exhaled breathe condensate collected on a Jaeger Ecoscreen condenser unit (Cardinal Health, Yorba Linda, CA) with Na+ quantification using an atomic absorption spectrophotometer (Analyst 100; Perkin Elmer, Norwalk, CT) and Cl- anion quantification using a Dionex AS11 HC column. Healthy n=31 (n=18[58%], 9[29%], and 4[13%] subjects; Body mass index (BMI)=23±1, 25±2, and 25±2kg/ m2 for AA, AT and TT groups respectively). CF n= 42 (n=33[79%], 7[16%], and 2[5%] subjects; BMI equals 23±7, 19±0.4, and 20±2.2kg/m2 for AA, AT and TT groups respectively). Main Results: We found that the distribution of genotypes in CF differed from healthy subjects, with the AA genotype in 80% of CF and 59% in healthy. No significant difference were demonstrated in healthy subjects between genotype groups for pulmonary function and exhaled chloride while the genotypes did differ in exhaled Na (Na=2.9±0.4, 1.7±0.3, and 3.7±1.1mmol/L for AA, AT, and TT respectively, ANOVA p=0.07). CF subjects with the AA genotype had a higher baseline exhaled Cl-, FEV1, and FEFmax than those in the AA group (Cl=0.125±0.038,0.0 27±0.007, and 0.033±0.02 mmol/L ; FEV1=71±5, 68±11, and 40±22L; FEFmax=86±4, 72±7, and 44±24L/sec; for AA, AT, and TT respectively, ANOVA p<0.05, Tukey [AA vs. TT] p<0.05) while exhaled Na+ and FVC were similar between genotypes. Conclusions: Our results suggest that CF subjects with the AA genotype of the alpha subunit of the ENaC have a higher baseline exhaled Cl- and a resulting increase in pulmonary function when compared to the overactive TT groupCF patients with the TT αENaC genotype are likely candidates for early identification and treatment with inhaled ENaC inhibitors or other modulators of this pathway in order to improve survival.
Foxx-Lupo, William T., e Eric M. Snyder. "Influence of Genetic Variation of the Alpha-Subunit of the Epithelial Sodium Channel (ENaC) on Baseline Pulmonary Function and Exhaled Sodium Ions (Na+) and Chloride Ions (Cl-) in Healthy Subjects and Patients with Cystic Fibrosis". The University of Arizona, 2012. http://hdl.handle.net/10150/614485.
Testo completoSpecific Aims: The epithelial sodium channels (ENaC) found on the apical membranes of epithelial cells including those lining the respiratory tract are the rate limiting step of the absorption of excess fluid from the airspace of the alveoli. ENaC function is modulated by the effects of various physiologic signals such as the adrenergic and purinergic pathways, in addition to other local channels which control the flow of negatively charged ions such as the cystic fibrosis transmembrane conductance regulator (CFTR). We sought to determine the influence of genetic variation on the alpha subunit of ENaC at amino acid position 663 on baseline exhaled ions and pulmonary function in patients with CF. Methods: We assessed pulmonary function ( forced vital capacity[FVC], forced expiratory volume in one second [FEV1], forced expiratory flow maximum[FEFmax]) using a Medical Graphics cardiopulmonary testing device (Minneapolis, MN). Measures of exhaled sodium (Na+) and chloride (Cl-) were obtained using exhaled breathe condensate collected on a Jaeger Ecoscreen condenser unit (Cardinal Health, Yorba Linda, CA) with Na+ quantification using an atomic absorption spectrophotometer (Analyst 100; Perkin Elmer, Norwalk, CT) and Cl- anion quantification using a Dionex AS11 HC column. Healthy n=31 (n=18[58%], 9[29%], and 4[13%] subjects; Body mass index (BMI)=23±1, 25±2, and 25±2kg/ m2 for AA, AT and TT groups respectively). CF n= 42 (n=33[79%], 7[16%], and 2[5%] subjects; BMI equals 23±7, 19±0.4, and 20±2.2kg/m2 for AA, AT and TT groups respectively). Main Results: We found that the distribution of genotypes in CF differed from healthy subjects, with the AA genotype in 80% of CF and 59% in healthy. No significant difference were demonstrated in healthy subjects between genotype groups for pulmonary function and exhaled chloride while the genotypes did differ in exhaled Na (Na=2.9±0.4, 1.7±0.3, and 3.7±1.1mmol/L for AA, AT, and TT respectively, ANOVA p=0.07). CF subjects with the AA genotype had a higher baseline exhaled Cl-, FEV1, and FEFmax than those in the AA group (Cl=0.125±0.038,0.0 27±0.007, and 0.033±0.02 mmol/L ; FEV1=71±5, 68±11, and 40±22L; FEFmax=86±4, 72±7, and 44±24L/sec; for AA, AT, and TT respectively, ANOVA p<0.05, Tukey [AA vs. TT] p<0.05) while exhaled Na+ and FVC were similar between genotypes. Conclusions: Our results suggest that CF subjects with the AA genotype of the alpha subunit of the ENaC have a higher baseline exhaled Cl- and a resulting increase in pulmonary function when compared to the overactive TT groupCF patients with the TT αENaC genotype are likely candidates for early identification and treatment with inhaled ENaC inhibitors or other modulators of this pathway in order to improve survival.
Ricci, Monia. "Analisi del segnale elettroencefalografico acquisito durante movimenti lenti e veloci dell'arto superiore". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/19910/.
Testo completoFast, Tobias. "Alpha Tested Geometry in DXR : Performance Analysis of Asset Data Variations". Thesis, Blekinge Tekniska Högskola, Institutionen för datavetenskap, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:bth-19730.
Testo completoBakgrund. Strålspårning(Ray tracing) kan användas för att uppnå hyperrealistisk 3D-rendering, men det är en mycket tung beräkningsuppgift. Sedan hårdvarustöd för att utföra strålspårning i realtid lanserades har spelindustrin introducerat funktionen i spel. Trots modern hårdvara upplevers fortfarande prestandaproblem när vanliga renderingstekniker kombineras med strålspårning. En av dessa problematiska tekniker är alfa-testning(alpha testing). Syfte. Denna avhandling kommer att undersöka följande: 1) Hur texturformatet på alfamasken(alpha map) och hur antalet alfamaskar påverkar renderingstiderna. 2) På vilket sätt tesselering av den alfa-testade geometrin påverkar prestandan och om tesselering har potentialen att ersätta alfa-testet helt ur ett prestandaperspektiv. Metod. En DXR 3D-renderare kommer att implementeras som kan rendera alfatestad geometri med hjälp av en “Any-hit” shader. Renderaren användes för att mäta och jämföra renderingstider givet varierande textur- och geometri-data. Två alfaprövade trädmodeller tesselaterades till olika nivåer och deras relaterade texturer konverterades till fyra format som användes i testscenerna. Resultat & Slutsatser. När texturformaten BC7, R(1xfloat32) och BC4 användes för alfamasken visade alla en minskad renderingstid relativ RGBA (4xfloat32). BC4 gav bästa prestandaökningen och minskade renderingstiden med upp till 17% med en alfamask per modell och upp till 43% med åtta alfamasker. När antalet alfamasker som användes per modell ökade renderingstiderna med upp till 52% när alfamaskerna ökade från en till två. En stor ökning av renderingstiden observerades när alfamaskerna gick från tre till fyra i alla testfall. När alfatestning användes på de tesselerade modellversionerna ökade renderingstiderna i de flesta fall, som högst 135%. En minskning på upp till 8% observerades emellertid när modellerna tesselaterades till en viss grad. Att stänga av alfatestning gav en signifikant ökning av prestandan, vilket tillät högre tesselerade versioner att renderas för alla modeller. Samtidigt som antalet trianglar ökade med en faktor på 78, i ett av fallen, minskades renderingstiden med 30%. Detta antyder att förtesselerade modeller potentiellt kan användas för att ersätta alfatestad geometri när prestanda är ett högt krav.
Danninger, Eva. "Der Einfluss genetischer Variationen im TNF alpha-Gen auf kognitive Phänotypen". Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-111165.
Testo completoDanninger, Eva. "Der Einfluss genetischer Variationen im TNF-alpha-Gen auf kognitive Phänotypen". kostenfrei, 2010. http://d-nb.info/1000694305/34.
Testo completoBashyam, Hema Sundara. "Serotype Cross-Reactive CD8+ T Cell Response to Heterologous Secondary Dengue Virus Infections in Humans: a Dissertation". eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/258.
Testo completoSchüttlöffel, Antje. "Einfluß genetischer Variationen im Tumor Nekrose Faktor-alpha Gen auf die Progession der HIV-Infektion und die Entstehung HIV-assoziierter Krankheiten". Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2002. http://dx.doi.org/10.18452/14672.
Testo completoObjective: We determined whether variation of the tumor necrosis factor-alpha gene had an impact on HIV disease progression or the prevalence of hiv-associated diseases. Methods: The promotor region of the TNF-alpha gene were examined with SSCP analysis for polymorphisms in the promotor region. The most common promotor polymorphisms were characterized with restriction fragment length polymorphism analysis (RFLP). To confirm RFLP results DNA fluorescence sequenzing analyses were performed with selected samples. In all cases with diagnosis of promotor polymorphisms single base transitions from guanine to adenine were confirmed. Results: Statistical analyses correlated the genotypes with different markers for disease progression e.g. CD4-count, the period from ARC to AIDS and the occurance of HIV associated diseases (wasting syndrome, hiv encephalopathy). In none of the statistical analyses significant association with a certain TNF-alpha genotyp could be demonstrated. Conclusion: For some subanalysis the sample sizes were too small in order to be able to make safe statistical statements concerning rare allels. Regarding our results, none of the examined tumor necrosis factor-alpha promotor polymorphisms had an impact on HIV disease progression or the prevalence of hiv-associated diseases.
AMRANI, YASSINE. "Role du recepteur p55 au tnfα dans les variations phenotypiques des cellules musculaires lisses des voies aeriennes : implication dans la physiopathologie de l'asthme". Strasbourg 1, 1995. http://www.theses.fr/1995STR15053.
Testo completoAnderson, Nicola Elizabeth. "The use of subtle variations in alpha-1-acid glycoprotein glycosylation to distinguish between specific liver diseases". Thesis, University of Strathclyde, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273446.
Testo completoPayette, Caroline. "Étude des variations plasmatiques postprandiales des marqueurs inflammatoires IL-6, TNF-alpha et CRP chez les hommes et les femmes". Thesis, Université Laval, 2007. http://www.theses.ulaval.ca/2007/24494/24494.pdf.
Testo completoKonan, Daniel. "Variations des glycoformes de l'α1-glycoprotéine acide humaine au cours de l'insuffisance hépatocellulaire et en fin de grossesse : étude d'une structure tétraanténnée et bifucosylée". Paris 11, 1990. http://www.theses.fr/1990PA114817.
Testo completoJacquelin, Béatrice. "Etude des bases moléculaires à l'origine des variations d'expression de la sous-unité alpha2 de l'intégrine alpha2beta1". Paris 7, 2001. http://www.theses.fr/2001PA077089.
Testo completoMeziou, Leïla Ikram. "Segmentation par contours actifs basés alpha-divergences : application à la segmentation d’images médicales et biomédicales". Thesis, Cergy-Pontoise, 2013. http://www.theses.fr/2013CERG0635/document.
Testo completoIn the particular field of Computer-Aided-Diagnosis, the segmentation of particular regions of interest corresponding usually to organs is still a challenging issue mainly because of the various existing for which the charateristics of acquisition are very different (corrupting noise for instance). In this context, this PhD work introduces an original histogram-based active contour segmentation using alpha-divergence family as similarity measure. The method keypoint are twofold: (i) the flexibility of alpha-divergences whose metric could be parametrized using alpha value can be adaptedto the statistical distribution of the different regions of the image and (ii) the ability of alpha-divergence ability to enbed standard distances like the Kullback-Leibler's divergence or the Hellinger's one makes these divergences an interesting unifying tool.In this document, first, we propose a supervised version of proposed approach:. In this particular case, the iterative process of segmentation comes from alpha-divergenceminimization between the current probability density function and a reference one which can be manually defined for instance. In a second part, we focus on the non-supervised version of the method inorder to be able.In that particular case, the alpha-divergence maximization between probabilitydensity functions of inner and outer regions defined by the active contour is maximized. In addition, we propose an optimization scheme of the alpha parameter jointly with the optimization of the divergence in order to adapt iteratively the divergence to the inner statistics of processed data. Furthermore, a comparative study is proposed between the different segmentation schemes : first, on synthetic images then, on natural images. Finally, we focus on different kinds of biomedical images (cellular confocal microscopy) and medical ones (X-ray) for computer-aided diagnosis
Payette, Caroline. "Étude des variations plasmatiques postprandiales des marqueurs inflammatoires IL-6, TNF-α et CRP chez les hommes et les femmes". Master's thesis, Université Laval, 2007. http://hdl.handle.net/20.500.11794/19150.
Testo completoSchüttlöffel, Antje. "Einfluss genetischer Variationen im Tumor Nekrose Faktor-alpha Gen auf die Progression der HIV-Infektion und die Entstehung HIV-assoziierter Krankheiten". [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963575465.
Testo completoBlay, Jean-Yves. "Analyse des variations des taux seriques de tnf, d'il-1 alpha d'il-6 au cours de l'administration systemique d'il-2 chez 51 patients porteurs d'un adenocarcinome du rein metastatique". Lyon 1, 1990. http://www.theses.fr/1990LYO1M334.
Testo completoAbdallah, Ali Nachaat. "Cytokynes et rejet de greffe de cœur et de moelle : suivi biologique de cytokines plasmatiques, implication de variations du gène du TNF-alpha dans le risque de rejet sévère de greffe cardiaque". Bordeaux 2, 1996. http://www.theses.fr/1996BOR28440.
Testo completoAmong the elements of the cytokine cascade occuring with a heart-graft rejection or developing when there are major bone marrow transplantation related complications (TRC), tumor necrosis alpha (TNF) alpha and interleukin-6 (IL-6) are highly implicated. We studied 186 patients who undervent a bone marrow transplantation (106 autografted and 80 allografted). They were investigated for retrospective plasma TNF alpha, IL-6 and soluble IL-2 receptor (sIL-2 R)levels in order to appreciate their possible implication in TRC development. The cytokine evolution was followed in the three periods : pre-graft, post-graft first quater, post-graft second quater. High levels of sIL-2-R and especially of IL-6 were noted in patients developing TRC or suffering from graft-versus host disease acute (GVHA) or chronic (GVHC). . TNF alpha showed no link between GVHA or TRC, but was associated with extensive GVHD. In a cohort of 142 patients, we analysed blood specimens contemporary with the histological biopsy. Significant differences of plasma interleukin-1 beta, IL-6 and TNF alpha levels appeared between patients without severe rejection. By studying weekly blood samples of a group of 27 patients from the day of the transplantation, it was possible to emphasize a specific TNF alpha increase in the severe rejection risk while it was not possible to demontrate the significance due to the too small number of our patient sample. The individual variabuility of TNF gene (extragenic polymorphisms, microsatellites, promotor sequence) was studied by restriction analysis and direct sequencing which demonstrated some interesting relations with TNF alpha production, especially a significant difference appearing for some TNFa microsatellites according to rejection gravity
Bartolomei, Fabrice. "Analyse des variations des arnm codant pour les isoformes de la sous-unite alpha des canaux na+ potentiel dependants dans le cerveau du rat : etude chez l'animal normal et dans un modele d'epilepsie experimentale". Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX20816.
Testo completoJezequel-Cuer, Maryvonne. "Enrichissement et caractéristiques enzymatiques d'une alpha1-3 fucosyltransférase hépatique humaine : étude des variations des activités a1-2, a1-3, a1-3/4 et a1-6 fucosyltransférasiques hépatiques au cours des pathologies hépatobiliaires". Paris 11, 1994. http://www.theses.fr/1994PA114815.
Testo completoRollin, Orianne. "Etude multi-échelle du patron de diversité des abeilles et utilisation des ressources fleuries dans un agrosystème intensif". Phd thesis, Université d'Avignon, 2013. http://tel.archives-ouvertes.fr/tel-00993034.
Testo completoChen, You-Peng. "Impact of genetic variation of tumor necrosis factor alpha (TNF-a) [(TNF alpha)] on gestational hypertension /". 2005. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=013149207&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Testo completoHolmes, Mark D. (Mark Derek). "Molecular analyses of alpha 1-antitrypsin variation and deficiency / by Mark D. Holmes". 1992. http://hdl.handle.net/2440/38329.
Testo completoxviii, 219, [48] leaves of plates :
Title page, contents and abstract only. The complete thesis in print form is available from the University Library.
Analyses of six rare alpha 1-antitrypsin alleles were undertaken to determine their molecular basis, assess the biosynthesis directed by these alleles and, examine their clinical correlation.
Thesis (M.D.)--University of Adelaide, Dept. of Medicine, 1992
Liu, He. "Individual variation and hormonal modulation of sodium channel alpha and beta1 subunits in the electric organ correlate with variation in a social signal". Thesis, 2006. http://hdl.handle.net/2152/2764.
Testo completoHuang, Shiao Chi, e 黃曉琦. "Variation of alpha 1 acid glycoprotein in cats subjected to spay surgery and parvovirus infection". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/vfk6g2.
Testo completo國立屏東科技大學
獸醫學系所
105
Alpha 1 acid glycoprotein (AGP), which is also named orosomucoid (ORM), is a moderate acute phase protein in cats and regulated by interleukin-1, interleukin-6, and tumor necrosis factor α. The feline AGP that raises after any tissue injury and inflammatory procedure, has been proven a diagnostically useful item. However, it is still not been widely applied in clinical practices. The common reason may be associated with the high cost and time consuming of the laboratory procedures. Thus, the aim of the study is to evaluate its values on clinical application. There are three parts in this study. First, we established the basic blood profiles, included concentrations of AGP, total proteins, albumin, and white blood cells (WBC) in clinical healthy cats. Second, we performed surgery (castration or ovariohysterectomy) on normal healthy cats and evaluated the correlations between levels of AGP and other hematological and biochemistry values postoperatively. Third, clinical applications of AGP on parvovirus infected cats. The results indicated the regional clinical healthy cat’s AGP reference range was under 800 mg/L. Peak concentration of AGP (1.9-2.6 fold) were observed on day 2 postoperatively. The AGP of females was significant higher on day 2 postoperatively than presurgery and there were no significant differences noted between sex. There is high positive relationship between AGP and WBC. For the parvovirus infected cats, there was high relation (r=-0.721) between AGP values and the levels of qPCR at the admission. Besides, AGP values were significantly lower (P<0.05) in recovered cats than died cats at the 5th, 7th, 9th, and 11th day after admission. To summarized the study: (1) in a healthy population, feline AGP concentration is under 800mg/L. (2) According to the variation of AGP concentration, the impaction of standard localized and sterilized surgery is less than generalized infection (3) Low Cq value of qPCR and high plasma AGP levels indicate the severity of feline panleokopenia and may be used to indicate the yield of clinical signs (4) Panleukopenia infected cats that survived longer than 5 days usually recovered and the plasma AGP levels may serve as a predictor of recovery.
Hewitt, Rachel. "An investigation into the ancestry of the Malagasy population using variation in the alpha- and beta-globin gene cluster". Thesis, 2014.
Cerca il testo completoThe issue of Malagasy ancestry has been controversial, and has still not been completely resolved. The historical, linguistic, archaeological and some genetic evidence points to the fact that modern Malagasy are the descendants of immigrants who arrived on the island over the past 2000 years, from South and Southeast Asia, Africa and the Near East. In more recent centuries, mainly in the twentieth century, there have been significant numbers of Indian, Chinese and French immigrants. In addition, archaeological and historical studies of specific regional populations of Malagasy suggest a complex pattern of internal migration within the island, extending back in time to the first European contacts with the island in the sixteenth century. The 22 Malagasy ethnic groups may be classified as "highland" or "lowland" depending on their geographic distribution on the island. Within the ethnic groups, the founding populations have made different genetic contributions: the highland groups are said to have a greater Indonesian contribution to their ancestry, while the lowlanders have a greater African contribution to their ancestry. Genetic studies on the Malagasy have been limited by small sample sizes, deficiencies in sampling procedures and in the limited number of polymorphisms studied. In light of the paucity of written records, the Department of Human Genetics, SAIMR, has undertaken a large study in Madagascar to reconstruct the biological history of its people, using genetic variation. This thesis forms a part of this study. Variation in the a- and p-globin cluster has been extensively studied in many parts of the world, and has been shown to be population specific, with specific variants having distinct geographical distributions. Thus haemoglobin and its related disorders have been the subject of extensive studies for determining the origin(s) of particular populations. In this study, some of the a- and p-globin variation present in the Malagasy was characterised. Seven RFLPs/HVRs in the a-globin gene cluster and seven RFLPs in the p-globin gene cluster were analysed. The common a- and p-globin gene cluster haplotypes differ between African and Asian populations. Frequencies also vary between populations in a specific geographical regions. The aim of this study was to characterise the haplotypes present in the Malagasy, to provide information on the relative genetic contributions of different populations to the peoples of Madagascar. DNA samples from randomly selected, haematologically normal individuals were analysed. Individuals were chosen from six Malagasy ethnic groups: two “highland” populations (Merina and Betsileo), two “lowland" populations (Antasaka and Tsimiheti) and two populations from the south-west of the island (Mahafaly and Vezo). The groups chosen cover a broad range of Madagascar and thus provide some representation of the Malagasy population as a whole. The number of individuals studied in each ethnic group are as follows: Merina: 88; Betsileo: 78; Antasaka: 67; Tsimiheti: 67; Mahafaly: 26; Vezo: 25. The frequencies of the a- and (B-globin RFLP sites and a-globin HVRs in the Malagasy vere calculated. 5' and 3’ p-globin haplotypes were constructed on the basis of homozygosity. A maximum-likelihood algorithm was used to obtain frequencies of 5’ P-globin haplotypes that could not be assigned on the basis of homozygosity. These data were then subject to statistical analysis. The frequencies of the 5’ p-globin haplotypes (consisting of the five sites Hindi 5' to e, Hindi 11 within Gy and Ay, Hindi within \|/P and 3' to it) were the most informative data set for comparing the Malagasy ethnic groups to each other and to other world populations. Unfortunately, the maximum-likelihood estimates of 5‘ p-globin haplotypes could not be used for comparative analyses due to the lack of similar data in other populations. However the strong correlation between the maximum-likelihood frequencies and the observed frequencies illustrated the ability of the algorithm to determine hapiotype frequencies from otherwise uninformative individuals. 5’ p-globin haplotypes were assigned unambiguously for 248 Malagasy chromosomes. Ten haplotypes were found; of these, nine have been reported previously in other world populations and one has not been reported and hns thus been called “rare” in this study. The frequencies of unambiguous 5’ p-globin haplotypes in the Malagasy and the proposed parental populations were initially analysed with x2 tests. For a more accurate comparison between these populations, genetic distances were calculated and used for the construction of phylogenetic trees, principle component analysis was carried out, and a study of heterozygosity versus distance from the centroid was performed. Admixture estimates of two African populations and one Indonesian population to Malagasy ancestry were calculated. Certain general trends were noted in all the analyses. The results are in agreement with the historical data which provides evidence for both African and Asian contributions to Malagasy ancestry. The highlanders were more closely affiliated to the Indonesian/Polynesian populations, while the south-west groups showed the strongest associations with the African populations. The lowlanders were consistently intermediate in position between the highlanders and the south-west groups, with the Antasaka being slightly more closely related to the African populations than the Tsimiheti. The Malagasy were shown to have high heterozygosities, similar to those of African populations, and this high degree of diversity is probably a reflection of the many sources of ancestry of the Malagasy. The south-west groups were the furthest outliers in the model of heterozygosity versus distance from the centroid, suggesting that these groups are the most genetically admixed of all the Malagasy groups that were studied. Estimates of ancestral population admixture confirmed these trends, with the highlanders having the highest proportional contribution by Indonesians (53%), but the lowest total African contribution (47%), while the south-west groups have the highest Bantu contribution (65%). The Indonesian and African contributions to the lowlanders are intermediate between those to highlanders and south-west groups. Overall the Malagasy subjects included in this study showed a 61% African admixture contribution and a 39% Indonesian admixture contribution. It is hoped that the results obtained in this study will contribute to the larger project concerning the origins of the Malagasy, and that they may be used to shed further light on the much debated issue of Malagasy ancestry.
SU, Guo-Hueng, e 蘇國鴻. "The variation of alpha-Al2O3 (1 0 -1 0) surface in difference annealing time and temprature". Thesis, 1996. http://ndltd.ncl.edu.tw/handle/83950744174569836546.
Testo completo國立清華大學
物理研究所
84
alpha-Al2O3 是一應用相當廣泛的陶瓷材料。它是氧化鋁化合物中純度最 高的一個,俗稱剛玉(corundum)。因為它的結構相當複雜,所以有較多低 指數和低能量的面。這些面已有相當多的研究成果。本文則是對其中的一 個面在不同的退火條件下的結果作進一步的探討。 alpha-Al2O3 在工業 及科學上是一個不可多得的材料,如高溫絕緣材料、光學鏡片、切割工具 、鍍膜基板、固體雷射...等。它之所以有這麼廣泛的應用要歸功於其 高機械硬度、高熔點、散熱快、絕緣性佳還有穩定的化學性質。 (1 0 -1 0) 面是幾個低指數面中能量較高的一個,退火時較不穩定,會分裂為 能量較低的兩個小面。到目前為止鮮少有人對這個面在不同退火溫度及不 同退火時間做進一步的探討。本文則要對此做深入探討。在 1400 °C 退 火 24 小時後有鋸齒狀的形貌出現,方向是 (1 1 -2 0)。其中一個面較 為平坦,另一個則非常粗糙。週期約為 50 nm 。但將退火溫度降為 1000 °C 時,其週期約只剩下 10 nm 左右。在 1400 °C及1000 °C 長 時間退火的條件下,形貌幾乎沒有改變。本文共分為八部份:一簡介;二 表面分析的重要性;三晶體結構;四相關的研究;五反射式電子顯微鏡簡 介;六實驗過程;七實驗結果;八結論;九進一步的工作。
Labisa, Pedro José Lourenço. "Variation in tumour necrosis factor-alpha inhibitors usage for rheumatoid arthritis between Portugal and The Netherlands". Master's thesis, 2017. http://hdl.handle.net/10451/36001.
Testo completoObjective: Analyse the evolution of biological tumour necrosis factor alpha (TNFalpha) inhibitors utilisation in the treatment of rheumatoid arthritis (RA) and identify the reasons for the observed variation. Methods: Two western European countries were selected for this analysis, Portugal and the Netherlands. Country characteristics, treatment guidelines and RA prevalence were obtained from the literature. Patient characteristics were obtained from the literature and from the data made available by the University Medical Center Utrecht, for Portugal and the Netherlands, respectively. Annual utilisation rates of TNFalpha inhibitors between 2008 and 2013 were expressed as defined daily doses (DDDs)/1000 inhabitants/day. Results: TNFalpha inhibitors utilisation varied from 0.18, in 2008, to 0.46 DDDs/1000 inhabitants/day, in 2013, in Portugal and from 0.98, in 2008, to 1.64 DDDs/1000 inhabitants/day, in 2013, in the Netherlands. Clinical guidelines, variations in GDP per capita, total health expenditure, medical goods expenditure and drug distribution channel, appear to have had limited impact on TNFalpha inhibitors utilisation. On average, Dutch RA patients under therapy with TNFalpha inhibitors appear to younger than their Portuguese counterparts. Conclusions: TNFalpha inhibitors utilisation continues to be increasing, despite the negative influences caused by the economic recession and posterior austerity measures. This increase in TNFalpha inhibitors utilisation was not equal in Portugal and in the Netherlands, which lead to a bigger difference in utilisation between both countries. The high percentage of undiagnosed Portuguese rheumatic patients might be one of the leading reasons for the anaemic utilization of TNFalpha inhibitors. The number of rheumatologists per 100,000 inhabitants, improved clinical efficiency and a reduction in drug pricing all seem to have positively influenced utilisation.
Objetivo: Analisar a utilização dos biológicos inibidores do fator de necrose tumoral alfa (TNF-alfa) no tratamento de artrite reumatoide (AR) e identificar as razões para a variação de utilização observada. Metodologia: Dois países europeus ocidentais foram selecionados para esta analise, Portugal e a Holanda. As características dos países, guidelines de tratamento e a prevalência foram obtidos da literatura. As características dos doentes com AR foram obtidas da literatura e a partir dos dados disponibilizados pelo University Medical Center Utrecht, para Portugal e Holanda, respetivamente. Ratios de utilização anuais dos inibidores do TNF-alfa entre 2008 e 2013 foram demonstrados como Dose Definida Diária (DDD)/1000 habitantes/dia. Resultados: A utilização dos inibidores do TNF-alfa variaram de 0.18, em 2008, para 0.46 DDD/habitantes/dia, em 2013, em Portugal e de 0.98, em 2008, para 1.64 DDD/habitantes/dia, em 2013, na Holanda. Guidelines clinicas, variações no GDP per capita, despesa total em saúde, despesa com produtos de saúde e canal de distribuição dos medicamentos, parecem ter tido um impacto limitado na utilização dos inibidores do TNF-alfa. Doentes holandeses com artrite reumatóide sob terapia dos inibidores do TNF-alfa são, em média, mais novos que os seus contrapartes portugueses. Conclusão: A utilização de inibidores do TNF-alfa continua a aumentar, mesmo com os efeitos negativos causados pela recessão económica e das medidas de austeridade implementas posteriormente. O aumento de utilização de inibidores do TNF-alfa não foi igual em Portugal e na Holanda, levando assim a um aumento na diferença de utilização destes medicamentos entre os dois países. A elevada percentagem de doentes portugueses não-diagnosticados pode ser uma das principais razões por detrás da utilização anémica de inibidores do TNF-alfa. O número de reumatologistas por 100.000 habitantes, aumento da eficiência clinica e reduções no preço dos fármacos parecem todos ser fatores que influenciaram positivamente a utilização destes fármacos.
Bteich, Michel. "Développement et validation de modèles in silico pour évaluer la variation de clairance hépatique des médicaments fortement liés aux protéines plasmatiques". Thesis, 2020. http://hdl.handle.net/1866/25525.
Testo completoThe prediction of pharmacokinetic/toxicokinetic (PK/TK) parameters such as intrinsic clearance (CLint) and hepatic clearance (CLh) for highly bound drugs is a major challenge in quantitative modeling. According to the ‘free drug hypothesis’, only the free drug can pass through the plasma membrane and the CLh of this drug is calculated according to its free fraction (fup). Nevertheless, the hepatic uptake facilitated by albumin (ALB) is a violation of the ‘free drug hypothesis’. This facilitated hepatic uptake is based on the possibility that the ALB-drug complex may provide additional drug intake to the hepatocytes. Thus, this could largely explain the underpredictions of CLh. In addition, some drugs can bind extensively in plasma, and to several plasma proteins such as ALB and alpha-1-glycoprotein acid (AGP). Thus, the high binding of the same drug to either ALB or AGP, or to both, could have distinct impacts on the prediction of these PK/TK parameters. However, no study has yet explored how to simulate the difference between these impacts. The main objective of this thesis is therefore to evaluate (with accuracy and precision) for a series of drugs, in the in vivo (or in situ) condition, these impacts in the presence of the two plasma proteins, jointly or separately. Also, it is important to verify if a generic model can be applied. This thesis is divided into three specific objectives. The first is to propose a decision tree to facilitate the selection of appropriate predictive approaches of CLhin vivo for drugs with different characteristics. The second is to assess the impacts of extensive binding to the two plasma proteins ALB and AGP on the CLh of two selected xenobiotics (perampanel (PER) and fluoxetine (FLU)); these drugs have strong affinities to both proteins and an exclusive (or predominant) metabolism in the liver. And the last objective is to develop and validate a new predictive model of CLh for xenobiotics with the potential to bind extensively to ALB as well as to AGP. Firstly, in vitro data obtained in humans were collected for 19 drugs (i.e. substrates of OAT2 and OATP1B1 transporters) and were then used in six in vitro-to-in vivo (IVIVE) extrapolation models to predict these PK/TK parameters. After a statistical comparison, the results showed that the approach 2 (i.e. ‘fup-adjusted model’) that is based on the ALB-facilitated hepatic uptake, had the best predictive performance. However, the approach 5 (i.e. ‘Extended Clearance Model’) that is based on the membrane transporter-mediated uptake, was very relevant to apply for the substrates of membrane transporters. These substrates would potentially be less affected by ALB. Thus, a decision tree has been proposed to quickly and judiciously select the best IVIVE approach to predict CLhin vivo for each xenobiotic in the presence of ALB. Secondly, the PER and FLU drugs were selected from a data collection of 1907 drugs depending on certain criteria (exclusive or predominant metabolism in the liver, no transport facilitated by membrane transporters, high affinity for the two proteins ALB and AGP, and having a binding ratio between AGP and ALB close to the unity). This selection was made to conduct experiments using the isolated and perfused rat liver (IPRL) apparatus, in the presence, and in the absence of the ALB and AGP proteins (i.e. four IPRL scenarios). The IPRL results showed that PER is low to moderately metabolized (hepatic extraction= 0.2-0.7), while FLU is highly metabolized (hepatic extraction= 0.8-0.99). The Michaelis-Menten model was fitted to the obtained metabolic kinetics, and different parameters Vmax, Km and Km, u were obtained from the model. At low free concentrations for both drugs (i.e. therapeutic concentrations) and in the presence of plasma proteins, the values of unbound CLint increased for PER (with ALB and the mixture of the two proteins (MIX)) and FLU (with ALB, AGP and MIX); when compared to those obtained from the protein-free scenario (except for PER with AGP, the unbound CLint values decreased). In addition, the calculations of CLint ratios (WITHOUT versus WITH protein) indicated the occurrence of a hepatic uptake facilitated by ALB or AGP. These ratios also helped in verifying whether the metabolic kinetics for PER and FLU followed either ‘the free drug hypothesis’ or that of ‘plasma protein-facilitated hepatic uptake’. Finally, a new predictive approach of CLh (WO-to-MIX approach) was developed based on a new notion of fractional binding and incorporating new parameters such as the ALB bound fraction (fB-ALB) and the AGP bound fraction (fB-AGP) from the MIX scenario into the ‘fup-adjusted model’. This model is based on the ‘ALB-facilitated hepatic uptake’. Unlike the WO-to-MIX approach, the ‘well-stirred model’ is based on ‘the free drug hypothesis’. Then, the Vmax and Km parameters that were obtained in situ for PER and FLU from the protein-free IPRL experiments, were used in combination with the fup-adjusted input parameter for the ‘fup-adjusted model’ or with the free fraction (fup) for the ‘well-stirred model’. A comparison of the two models’ overall predictive performances was made. The predictive performances of the new model were promising for FLU, which showed the highest degree of ‘ALB-mediated hepatic uptake’, compared to the conventional model. This WO-to-MIX approach is a first validation of a novel extrapolation model suggested for drugs such as FLU that bind to both ALB and AGP. The well-stirred model remains however a useful tool to predict the clearance for drugs such as PER. The prediction accuracy was lower for the latter drug probably because the ALB-mediated hepatic uptake does not seem to be maximal, and, hence, the use of fup-adjusted has overestimated its CLhin vivo. Therefore, more work is needed particularly for PER. This thesis shows that a generic approach to predict the CLh in vivo does not exist. Nevertheless, the choice of an IVIVE approach with satisfactory predictive performances is now possible. The results of this thesis contribute to: 1) better understand the impacts on the PK/TK parameters of extensive drug binding to ALB and AGP; 2) choose the best predictive approach to CLh based on the affinity of xenobiotic (drug or contaminant) to each of the plasma proteins and the mechanisms involved in the liver; and 3) predict accurately and with precision the output CLh of xenobiotics that bind to the two plasma proteins. These IVIVE approaches for CLh can certainly be integrated into physiologically based PK/TK models for xenobiotics to improve the prediction of their pharmacokinetics and to accelerate the drug development process.
Lin, Wan-chen, e 林宛蓁. "Structural Variations of alpha-Glycosylceramides and Their Influence on Natural Killer T Cell Activation". Thesis, 2002. http://ndltd.ncl.edu.tw/handle/06205285831201853478.
Testo completo國立臺灣大學
化學研究所
90
CD1 molecules are a family of MHC-like cell surface glycoproteins that present glycolipid antigens to T lymphocytes. Human CD1d and its mouse homolog are shown to present a special glycolipid, a-galactosyl ceramide (alpha-GalCer), to a subset of T lymphocytes called natural killer T (NKT) cells. It is suggested that NKT cells are activated through the TCR interaction with CD1d/ alpha-GalCer complex. NKT cells are thought to be immuno-regulators because they secrete large amounts of cytokines, such as IL-4 and INFgamma, after stimulation. They are also found to show antitumor activity and to control autoimmune responses. Among the reported glycolipids presented by human CD1d (or its mouse homolog), alpha-GalCer and alpha-GlcCer show the highest immuno-stimulatory activities. Some structural features of alpha-GalCer have been demonstrated necessary for antigen recognition by CD1-restricted NKT cells, including: (1) the alpha- anomeric glycosidic linkage between sugar and lipid moieties; (2) the 2-hydroxyl group on the pyranose ring; and (3) the presence of 3’ and 4’-hydroxyl groups on the phytosphingosine chain. Change of the antigen structure may alter the level of stimulatory activity and/or switch the cytokine pattern released by NKT cells. However, the information is still limited about how antigen structures influence the activation event. In order to obtain the scenario about structure-activity relationship of alpha-GalCer, we synthesized alpha-GalCer and its analogues based on the above-mentioned features. The synthetic approach was designed not only to increase versatility of the alpha-GalCer synthesis but also to accommodate the flexibility for further modification. The phytosphingosine moiety was replaced by corresponding serine ester or amide as the simplified lipids to afford analogues ANGX1-3. In addition, the model study for functional group replacement at sugar C-2 position was demonstrated. Finally, an ELISA assay was established to evaluate the stimulatory activities of these analogues and compare the results with that of alpha-GalCer.
Danninger, Eva [Verfasser]. "Der Einfluss genetischer Variationen im TNF-alpha-Gen auf kognitive Phänotypen / vorgelegt von Eva Danninger". 2010. http://d-nb.info/1000694305/34.
Testo completoNollett, Kenneth M. "Radiative alpha-capture cross sections from realistic nucleon-nucleon interactions and variational Monte Carlo wave functions /". 2000. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:9990580.
Testo completoPayette, Caroline. "Étude des variations plasmatiques postprandiales des marqueurs inflammatoires IL-6, TNF-[alpha] et CRP chez les hommes et les femmes /". 2007. http://www.theses.ulaval.ca/2007/24494/24494.pdf.
Testo completoSchüttlöffel, Antje [Verfasser]. "Einfluß genetischer Variationen im Tumor Nekrose Faktor-alpha Gen auf die Progression der HIV-Infektion und die Entstehung HIV-assoziierter Krankheiten / vorgelegt von Antje Schüttlöffel". 2001. http://d-nb.info/963575465/34.
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