Letteratura scientifica selezionata sul tema "Allo-reactivity"
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Articoli di riviste sul tema "Allo-reactivity"
Huisman, Wesley, Didier A. T. Leboux, Lieve E. van der Maarel, Lois Hageman, Derk Amsen, J. H. Frederik Falkenburg e Inge Jedema. "The Scope of Allo-HLA Cross-Reactivity By (Third Party) Virus Specific T Cells Is Surprisingly Affected By HLA Restriction Rather Than Virus Specificity". Blood 132, Supplement 1 (29 novembre 2018): 2048. http://dx.doi.org/10.1182/blood-2018-99-116028.
Testo completoWebb, S. R., J. H. Li, I. MacNeil, P. Marrack, J. Sprent e D. B. Wilson. "T cell receptors for responses to Mls determinants and allo-H-2 determinants appear to be encoded on different chromosomes." Journal of Experimental Medicine 161, n. 1 (1 gennaio 1985): 269–74. http://dx.doi.org/10.1084/jem.161.1.269.
Testo completoAmir, Avital L., Lloyd J. A. D'Orsogna, Dave L. Roelen, Marleen M. van Loenen, Renate S. Hagedoorn, Renate de Boer, Menno A. W. G. van der Hoorn et al. "Allo-HLA reactivity of virus-specific memory T cells is common". Blood 115, n. 15 (15 aprile 2010): 3146–57. http://dx.doi.org/10.1182/blood-2009-07-234906.
Testo completoHuisman, Wesley, Didier A. T. Leboux, Lieve E. van der Maarel, Lois Hageman, Derk Amsen, Fred Falkenburg e Inge Jedema. "Off-Target HLA Cross-Reactivity By (Third Party) Virus-Specific T Cells Is Surprisingly Affected By HLA Restriction and HLA Background but Not By Virus Specificity". Blood 134, Supplement_1 (13 novembre 2019): 4440. http://dx.doi.org/10.1182/blood-2019-124785.
Testo completoHasenkamp, Justin, Andrea Borgerding, Bjoern Chapuy, Gerald Wulf, Inga Missal, Wolfram Jung, Lorenz Truemper e Bertram Glass. "Allo-Reactive NK Cells after HLA-Matched Allogeneic Hematopoietic Stem Cell Transplantation." Blood 108, n. 11 (16 novembre 2006): 2904. http://dx.doi.org/10.1182/blood.v108.11.2904.2904.
Testo completoWebb, S. R., A. Okamoto e J. Sprent. "Analysis of T hybridomas prepared from a T cell clone with three specificities. Recognition of self + X and allo-H-2 determinants segregates from recognition of Mlsa determinants." Journal of Immunology 141, n. 6 (15 settembre 1988): 1828–34. http://dx.doi.org/10.4049/jimmunol.141.6.1828.
Testo completoElkon, Keith B., e Dalit Ash Any. "Autoimmunity Versus Allo- and Xeno-Reactivity in SCID Mice". International Reviews of Immunology 11, n. 4 (gennaio 1994): 283–93. http://dx.doi.org/10.3109/08830189409051175.
Testo completoLaghmouchi, Aicha, Conny Hoogstraten, Peter Van Balen, Rick van de Water, Marian van de Meent, J. H. Frederik Falkenburg e Inge Jedema. "The Allo-HLA-DP Restricted T Cell Repertoire Contains a Variety of Tissue-Restricted Specificities with Therapeutic Value". Blood 128, n. 22 (2 dicembre 2016): 3356. http://dx.doi.org/10.1182/blood.v128.22.3356.3356.
Testo completoNoonan, Kimberly, Leo Luznik e Ivan M. Borrello. "Enrichment of Allogeneic Tumor Antigen-Specific T Cells From Bone Marrow (BM) of Patients Treated with High-Dose Post-Transplant Cyclophoshamide (Cy) – A Novel Approach to Adoptive Immunotherapy". Blood 118, n. 21 (18 novembre 2011): 647. http://dx.doi.org/10.1182/blood.v118.21.647.647.
Testo completoD’Orsogna, Lloyd, Heleen van den Heuvel, Cees van Kooten, Sebastiaan Heidt e Frans H. J. Claas. "Infectious pathogens may trigger specific allo-HLA reactivity via multiple mechanisms". Immunogenetics 69, n. 8-9 (17 luglio 2017): 631–41. http://dx.doi.org/10.1007/s00251-017-0989-3.
Testo completoTesi sul tema "Allo-reactivity"
Nattes, Tristan de. "Rejet humoral d'allogreffe rénale et allo-immunisation HLA". Electronic Thesis or Diss., Normandie, 2023. http://www.theses.fr/2023NORMR053.
Testo completoKidney transplantation is the best treatment of end-stage renal disease, improving life quality and quantity. Despite advances in pathophysiological knowledge of kidney transplant immunology, kidney transplant rejection remains the major cause of allograft dysfunction, especially antibody-mediated rejection.Antibody-mediated rejection risk assessment is based on the evaluation of donor-specific anti-HLA antibodies. However, these antibodies have a poor predictive value for incidence and prognosis of rejection. This could be explained by the heterogeneity of their intrinsic characteristics. These characteristics depend on cells responsible for their secretion, which include short- and long- lived plasma cells. Consequently, they indirectly depend on the cells responsible for maintaining the pool of these antibody-secreting cells, such as memory B cells. In infectious diseases, it is known that memory B cells are heterogeneous in terms of phenotype, function, degree of clonality, and diversification of their B-cell receptor (BCR). However, this heterogeneity has not been examined in the context of kidney transplantation.The aim of the first part of this thesis was to study the heterogeneity of HLA-specific memory B cells in sensitised patients on kidney transplant waiting list. To this end, single-cell analysis of HLA-specific memory B cells from patients with various aetiologies and degrees of immunisation was performed. This led to their phenotypic and transcriptomic characterisation and to the assessment of their BCR repertoire.The second part of this thesis was dedicated to the diagnosis of kidney transplant rejection.In recent years, biopsy-based transcriptomics has emerged, enabling the assessment of hundreds of transcripts in kidney biopsy tissue. These tools provide the opportunity to elucidate new physiopathological pathways and potentially enhance the diagnosis of rejection, especially humoral rejection. However, their application in clinical practice is still limited due to their restricted availability, required expertise for data processing and interpretation, and cost. Furthermore, their exact impact on patient management remains undetermined. Here, a molecular diagnostic tool with characteristics suitable for clinical use was developed. This tool enables the diagnosis of rejection and its classification between antibody-mediated and T-cell mediated rejection. Subsequently, this tool was assessed in ambiguous clinical situations to evaluate its impact in clinical practice.Through these studies, this thesis focused on enhancing our understanding of the humoral response in renal transplantation, which could help improving immunological risk stratification in transplantation. Additionally, it aimed to improve biopsy-based transcriptomics in the diagnosis of kidney transplant rejection
Capitoli di libri sul tema "Allo-reactivity"
D’Orsogna, Lloyd J., Ellen M. W. van der Meer-Prins, Yvonne M. Zoet, Dave L. Roelen, Ilias I. N. Doxiadis e Frans H. J. Claas. "Detection of Allo-HLA Cross-Reactivity by Virus-specific Memory T-Cell Clones Using Single HLA-Transfected K562 Cells". In Methods in Molecular Biology, 339–49. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-842-9_19.
Testo completoAtti di convegni sul tema "Allo-reactivity"
Howie, Duncan, Terri V. Cornforth, Nathifa Moyo, Suzanne Cole, Emily Lam, Tatiana Lobry, Ron Wolchinsky et al. "362 Allelic variants of MR1 drive cancer and allo-reactivity by MR1-restricted T cells". In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.0362.
Testo completo