Accedi

Bibliografie tematiche / Advanced dissolution

Letteratura scientifica selezionata sul tema "Advanced dissolution"

Autore: Grafiati

Pubblicato: 8 giugno 2024

Cita una fonte nei formati APA, MLA, Chicago, Harvard e in molti altri stili

Scegli il tipo di fonte:

Consulta la lista di attuali articoli, libri, tesi, atti di convegni e altre fonti scientifiche attinenti al tema "Advanced dissolution".

Accanto a ogni fonte nell'elenco di riferimenti c'è un pulsante "Aggiungi alla bibliografia". Premilo e genereremo automaticamente la citazione bibliografica dell'opera scelta nello stile citazionale di cui hai bisogno: APA, MLA, Harvard, Chicago, Vancouver ecc.

Puoi anche scaricare il testo completo della pubblicazione scientifica nel formato .pdf e leggere online l'abstract (il sommario) dell'opera se è presente nei metadati.

Indice

Articoli di riviste
Tesi
Libri
Capitoli di libri
Atti di convegni
Rapporti di organizzazioni

Articoli di riviste sul tema "Advanced dissolution":

1

Denninger, Alexander, Tim Becker, Ulrich Westedt e Karl G. Wagner. "Advanced In Vivo Prediction by Introducing Biphasic Dissolution Data into PBPK Models". Pharmaceutics 15, n. 7 (19 luglio 2023): 1978. http://dx.doi.org/10.3390/pharmaceutics15071978.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Abstract (sommario):

Coupling biorelevant in vitro dissolution with in silico physiological-based pharmacokinetic (PBPK) tools represents a promising method to describe and predict the in vivo performance of drug candidates in formulation development including non-passive transport, prodrug activation, and first-pass metabolism. The objective of the present study was to assess the predictability of human pharmacokinetics by using biphasic dissolution results obtained with the previously established BiPHa+ assay and PBPK tools. For six commercial drug products, formulated by different enabling technologies, the respective organic partitioning profiles were processed with two PBPK in silico modeling tools, namely PK-Sim and GastroPlus®, similar to extended-release dissolution profiles. Thus, a mechanistic dissolution/precipitation model of the assessed drug products was not required. The developed elimination/distribution models were used to simulate the pharmacokinetics of the evaluated drug products and compared with available human data. In essence, an in vitro to in vivo extrapolation (IVIVE) was successfully developed. Organic partitioning profiles obtained from the BiPHa+ dissolution analysis enabled highly accurate predictions of the pharmacokinetic behavior of the investigated drug products. In addition, PBPK models of (pro-)drugs with pronounced first-pass metabolism enabled adjustment of the solely passive diffusion predicting organic partitioning profiles, and increased prediction accuracy further.

2

Orian, Laura. "Editorial: Special Issue on “Advanced Strategies for Catalyst Design”". Catalysts 11, n. 1 (31 dicembre 2020): 38. http://dx.doi.org/10.3390/catal11010038.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

3

Fan, Xuliang, Yangfan Zhang, Jing Li, Kang Yang, Zhongxin Liang, Yaoguang Chen, Cunyuan Zhao, Zishou Zhang e Kancheng Mai. "A general dissolution–recrystallization strategy to achieve sulfur-encapsulated carbon for an advanced lithium–sulfur battery". Journal of Materials Chemistry A 6, n. 25 (2018): 11664–69. http://dx.doi.org/10.1039/c8ta02180e.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Abstract (sommario):

A novel dissolution–recrystallization strategy is, for the first time, proposed to fabricate a series of carbon@S cathodes via dissolution–recrystallization of granular sulfur into uniform sulfur layer encapsulated carbon in selective solution.

4

Kryeziu, Arjeta, Václav Slovák e Alžběta Parchaňská. "Liquefaction of Cellulose for Production of Advanced Porous Carbon Materials". Polymers 14, n. 8 (16 aprile 2022): 1621. http://dx.doi.org/10.3390/polym14081621.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Abstract (sommario):

Cellulose is a renewable resource for the production of advanced carbonaceous materials for various applications. In addition to direct carbonization, attention has recently been paid to the preparation of porous carbons from liquid cellulose-based precursors. Possible pathways of cellulose conversion to a liquid state suitable for the preparation of porous carbons are summarized in this review. Hydrothermal liquefaction leading to liquid mixtures of low-molecular-weight organics is described in detail together with less common decomposition techniques (microwave or ultrasound assisted liquefaction, decomposition in a strong gravitation field). We also focus on dissolution of cellulose without decomposition, with special attention paid to dissolution of nonderivatized cellulose. For this purpose, cold alkalines, hot acids, ionic liquids, or alcohols are commonly used.

5

Cappelli, Chiara, Daniel Lamarca-Irisarri, Jordi Camas, F. Javier Huertas e Alexander E. S. Van Driessche. "In situ observation of biotite (001) surface dissolution at pH 1 and 9.5 by advanced optical microscopy". Beilstein Journal of Nanotechnology 6 (5 marzo 2015): 665–73. http://dx.doi.org/10.3762/bjnano.6.67.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Abstract (sommario):

Laser confocal differential interference contrast microscopy (LCM-DIM) allows for the study of the reactivity of surface minerals with slow dissolution rates (e.g., phyllosilicates). With this technique, it is possible to carry out in situ inspection of the reacting surface in a broad range of pH, ionic strength and temperature providing useful information to help unravel the dissolution mechanisms of phyllosilicates. In this work, LCM-DIM was used to study the mechanisms controlling the biotite (001) surface dissolution at pH 1 (11 and 25 °C) and pH 9.5 (50 °C). Step edges are the preferential sites of dissolution and lead to step retreat, regardless of the solution pH. At pH 1, layer swelling and peeling takes place, whereas at pH 9.5 fibrous structures (streaks) form at the step edges. Confocal Raman spectroscopy characterization of the reacted surface could not confirm if the formation of a secondary phase was responsible for the presence of these structures.

6

Lyu, Xiaocong, e Denis Voskov. "Advanced modeling of enhanced CO2 dissolution trapping in saline aquifers". International Journal of Greenhouse Gas Control 127 (luglio 2023): 103907. http://dx.doi.org/10.1016/j.ijggc.2023.103907.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

7

Justen, Anna, Alina Faye Weltersbach, Gerhard Schaldach e Markus Thommes. "Design and Characterization of a Melt Electrostatic Precipitator for Advanced Drug Formulations". Processes 12, n. 1 (1 gennaio 2024): 100. http://dx.doi.org/10.3390/pr12010100.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Abstract (sommario):

Electrostatic precipitators (ESP) are especially known for the efficient separation of micron and submicron particles from aerosols. Wet electrostatic precipitators are particularly suitable for highly resistive materials. Using these, particles can be directly transferred into a liquid for further processing or safer handling, which is advantageous for either hazardous or valuable materials. In this work, a wet ESP, which enables the separation of highly resistive particles into a heated liquid, was designed and investigated. To do this, spray-dried drug particles were embedded in a molten sugar alcohol to enhance the drug dissolution rate. After cooling, the solidified product showed advantageous properties such as a high drug dissolution rate and easy handling for further processing. For the design of the wet ESP, different discharge electrode configurations were tested. A wall film served as the collection electrode, which was generated by a specially designed distributer die. A laminar flow regime was achieved with a homogeneous film serving as the collection electrode, which is particularly important for a high separation efficiency. A prototype was designed and constructed in this respect. The particle separation into hot liquids or onto hot surfaces is challenging due to thermal effects in ESPs. The influence of thermophoresis and drag force on the particle transport was investigated, and optimum operation parameters were found for the present ESP. A broad field of applications can be covered with the presented device, where particles are embedded in even hot liquids to form liquid suspensions or, as it is presented here, solid dispersions. The dissolution of the drug-containing solid dispersion was studied in vitro. A remarkably faster drug dissolution was observed from the solid dispersion, as compared to a powder mixture of the drug and xylitol.

8

Sekine, Nobuhide, e Wataru Nakao. "Advanced Self-Healing Ceramics with Controlled Degradation and Repair by Chemical Reaction". Materials 16, n. 19 (23 settembre 2023): 6368. http://dx.doi.org/10.3390/ma16196368.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Abstract (sommario):

Controlling the chemical reaction rate concerning degradation and repair is found to be important to design advanced self-healing ceramics. The recovery and degradation behaviors of strength and stiffness were investigated by exposing aqueous solutions of different pH and calcium ion concentrations to the introduced crack on typical self-healing ceramics dispersed with alumina cement as a self-healing agent. The chemical reaction of cement undergoes the following three stages: dissolution of components such as calcium ions, formation of a gel, and formation of final products. Experimental and thermodynamic assessments revealed that even under conditions where the final products are identical (thermodynamic equilibrium), kinetic effects (excessive dissolution of components or insufficient crystal formation) result in strength degradation rather than repair. It was also suggested that the repair function could be enhanced by controlling the nucleation site of the crystals.

9

Abou-Taleb, Heba A., Wesam W. Mustafa, Tarek Saad Makram, Lamiaa N. Abdelaty, Hesham Salem e Hamdy Abdelkader. "Vardenafil Oral Dispersible Films (ODFs) with Advanced Dissolution, Palatability, and Bioavailability". Pharmaceutics 14, n. 3 (26 febbraio 2022): 517. http://dx.doi.org/10.3390/pharmaceutics14030517.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Abstract (sommario):

Oral, quick response, and on demand, also known as a spontaneous oral treatment for erectile dysfunction, is highly needed by both patients and physicians. Vardenafil is selective (fewer side effects) and more effective in difficult-to-treat conditions than sildenafil. This study aims at fostering the dual objectives of using biomolecules such as artificial sweetening agents to solubilize and mask the bitterness of vardenafil loaded on biodegradable polymeric materials (PVA, MC, SA, and PVP K30) to fabricate oral, fast-dissolving films (vardenafil ODFs) in the mouth without the need for water to ingest the dosage form. Furthermore, coprecipitated-dispersed mixtures of vardenafil and three sweeteners (sorbitol, acesulfame K, and sucralose) were prepared and characterized using FTIR, DSC, and solubility studies. Moreover, eight different vardenafil ODFs were prepared using the solvent-casting method. Modified gustatory sensation test, in vitro disintegration, and release studies were performed. In addition, the optimized ODF (F8) was compared with the commercial film-coated tablets pharmacokinetically (relative bioavailability, onset, and duration of actions were estimated). The results indicated that the three sweetening agents had comparable solubilizing capacity. However, both sucralose- and acesulfame K-based ODFs have a more enhanced sweet and palatable taste than sorbitol-sweetened ODF. The SA- and PVP K30-based ODFs showed significantly faster disintegration times and release rates than MC. In conclusion, PVA has good film-forming properties, but a higher ratio of PVA adversely affected the disintegration and release characteristics. The % relative bioavailability for ODF was 126.5%, with a superior absorption rate constant (Ka) of 1.2-fold. The Cmax and estimated Tmax were compared to conventional film-coated tablets.

10

SAITO, Takayuki, Takeo KAJISHIMA e Katsumi TSUCHIYA. "Deep Ocean CO2 Sequestration via GLAD (Gas-Lift Advanced Dissolution) System". Journal of Environment and Engineering 6, n. 2 (2011): 412–15. http://dx.doi.org/10.1299/jee.6.412.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Più fonti

Tesi sul tema "Advanced dissolution":

1

Hoskins, Trevor P. J. II. "Characterization of Substituted Polynorbornenes for Advanced Lithography". Diss., Georgia Institute of Technology, 2005. http://hdl.handle.net/1853/8727.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Abstract (sommario):

A fundamental characterization of hexafluoroalcohol substituted polynorbornene (HFAPNB) was completed to improve the final photoresist formulation using these materials. In this work, it was found that the dissolution behavior of these materials was controlled by the ability of polymer chains to form hydrogen bonds. This ability to form interchain hydrogen bonds was affected by stereochemical changes in the polynorbornene backbone as molecular weights increase. These observed changes in backbone polynorbornene stereochemistry were accurately modeled using the "helix-kink" theory, first described by Ahmed and Ludovice. It was found that several material properties altered the interchain hydrogen bonding within these materials, such as the polydispersity, polymerization catalyst, and the polymer film thickness. However, none of these material properties altered the unusual dissolution behavior observed in these materials. To improve the potential formulation of these materials, the interactions between HFAPNB and resist additives were studied. For all tested photoacid generators, it was found that some interchain hydrogen bonding occurred between resist additive molecules and HFA side groups, which retarded the dissolution rate in the formulated material. In particular, one can create a simple resist using unprotected HFAPNB polymer with an iodonium photoacid generator. Finally, a series of norbornene oligomers were evaluated as potential dissolution inhibitors for HFAPNB. It was found that the dissolution rate of HFAPNB can be completely inhibited with dissolution inhibitors at a loading of 15%.

2

Maher, Christopher John. "Options for treatment of legacy and advanced nuclear fuels". Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/options-for-treatment-of-legacy-and-advanced-nuclear-fuels(984fa9e5-3732-4f1b-b9b1-42457ef0f732).html.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Abstract (sommario):

The treatment of advanced nuclear fuels is relevant to the stabilisation of legacy spent fuels or nuclear materials and fuels from future nuclear reactors. Historically, spent fuel reprocessing has been driven to recover uranium and plutonium for reuse. Future fuel cycles may also recover the minor actinides neptunium, americium and perhaps curium. These actinides would be fabricated into new reactor fuel to produce energy and for transmutation of the minor actinides. This has the potential to reduce the long lived radioactivity of the spent fuel and reprocessing high level waste, whilst also maximising energy production. To achieve these aims there are a range of materials that could be used as advanced nuclear fuels, these include metals, oxides, carbides, nitrides and composite materials, and these fuels may also be alloyed. These advanced fuels may need to be reprocessed, and as head end is the first chemical treatment step in a reprocessing plant, the issues caused by treating these advanced fuels are faced primarily by head end. Changes to the overall reprocessing specification, such as reduction in discharge authorisations for volatile radionuclides, will have the greatest impact upon head end. All these factors may lead to the introduction of pre-treatment technologies (e.g. Voloxidation) or enhanced dissolution technologies, e.g. mediated dissolution using silver(II).Literature and experimental studies show that uranium dioxide and low plutonium content MOx dissolves in nitric acid via direct and indirect nitrate reduction. The indirect nitrous acid catalysed route is kinetically most significant. The kinetics for the dissolution of uranium dioxide and 5 % plutonium MOx have been derived experimentally. Studies of the dissolution of MOx pellets in concentrated nitric acid and near boiling conditions indicate that dissolution shows a degree of mass transfer limitation. Thermodynamic studies show that the pronounced reduction in the MOx dissolution extent at 30-40% plutonium is due to the thermodynamics of the key dissolution reactions. One technology that could be used to dissolve plutonium-rich residues that are generated from the reprocessing of MOx fuels is mediated dissolution. Inactive studies using linear staircase voltammetry (LSCV) and constant current bulk electrolysis (BE) have been used to optimise a 100 ml dissolution cell. The generation of silver(II) is dependent upon silver concentration, agitation and the size of the separator membrane. Whilst the stability of silver(II) is defined by the kinetics of water oxidation, this is dependent upon a number of factors including nitric acid concentration, silver(I):(II) ratio, temperature and the rate of migration from the catholyte into the anolyte. LSCV experiments have shown that Tafel analysis confirms there is a good relationship between potential and anode current density assuming oxygen evolution and silver(I) oxidation. Kinetic modelling of the BE experiments can be used to model the silver(II) generation, steady state and decomposition due to reaction with water. The dissolution cell has been demonstrated to be capable of dissolving plutonium dioxide to 200 g.l-1 in less than 2 hours with good faradaic efficiency.

3

Vincent, R. F. "An analysis of the dissolution and dispersion of ice in Nares Strait using advanced very high resolution radiometry". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0003/MQ44862.pdf.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

4

Alihussein, Hussein Verfasser], Manfred C. [Akademischer Betreuer] [Krafczyk e Martin [Akademischer Betreuer] Geier. "Massively parallel simulations of chemical dissolution in porous media based on advanced lattice Boltzmann models / Hussein Alihussein ; Manfred Krafczyk, Martin Geier". Braunschweig : Technische Universität Braunschweig, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:084-2020120310245.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

5

Alihussein, Hussein [Verfasser], Manfred [Akademischer Betreuer] Krafczyk e Martin [Akademischer Betreuer] Geier. "Massively parallel simulations of chemical dissolution in porous media based on advanced lattice Boltzmann models / Hussein Alihussein ; Manfred Krafczyk, Martin Geier". Braunschweig : Technische Universität Braunschweig, 2020. http://d-nb.info/122309085X/34.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

6

Sandbeck, Daniel John Seale [Verfasser], Karl J. J. [Akademischer Betreuer] Mayrhofer e Matthias [Gutachter] Arenz. "On the Dissolution of Platinum: From Fundamental to Advanced Catalytic Materials / Daniel John Seale Sandbeck ; Gutachter: Matthias Arenz ; Betreuer: Karl J. J. Mayrhofer". Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1205975268/34.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

7

Garzón, Losik Germán Alexander. "Étude et modélisation d’un procédé de dissolution poussée en réacteur continu – application aux oxydes (U, Pu)O₂". Electronic Thesis or Diss., Université de Lorraine, 2023. http://www.theses.fr/2023LORR0050.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Abstract (sommario):

Le multirecyclage du combustible nucléaire ouvre la possibilité de stabiliser l'inventaire de plutonium et de fermer complètement le cycle du combustible en France. Ce procédé permet le traitement des combustibles MOX (Mélange d'OXydes), plus riches en plutonium que les combustibles UOX utilisés actuellement, mais impliquant une adaptation des technologies existantes et la conception de nouveaux procédés de retraitement, en particulier celui de dissolution des oxydes d'uranium et de plutonium. De ce fait, l'étude expérimentale de la réaction de dissolution des oxydes mixtes dans l'acide nitrique, ainsi que la modélisation du procédé sont des éléments incontournables pour le développement de nouvelles technologies de dissolution. Dans ce contexte, la dissolution dans l'acide nitrique de trois oxydes mixtes (30, 40 et 65% Pu/(U+Pu)) et du pôle pur dioxyde de plutonium a été étudiée à l'aide d'un montage optique. Il a été mis en évidence que les oxydes fortement chargés en uranium se dissolvent selon un mécanisme autocatalytique similaire à celui identifié pour le dioxyde d'uranium, et qu'au-delà d'une teneur de 30% en plutonium, l'oxyde mixte présente un mécanisme de dissolution proche de celui du dioxyde de plutonium. Un modèle de dissolution d'une particule unique a été développé, en prenant en compte l'aspect fractal de la surface externe des particules, ainsi que de la surface réactive. Ce modèle a été validé par comparaison avec les données expérimentales issues de ce travail, ainsi que de la littérature. Un modèle de procédé pour la dissolution d'un ensemble de particules a été également développé, sur la base du modèle de dissolution d'une particule unique et intégrant les bilans de population. Ce modèle permet de comprendre le comportement d'un dissolveur à lit fluidisé, technologie qui présente des avantages intéressants vis-à-vis des réactions solide-fluide mises en œuvre. Il a permis de proposer une première étape dans la conception de procédés innovants de dissolution des combustibles MOX actuels et futurs
Plutonium multirecycling aims to stabilise the plutonium inventory and eventually close the fuel cycle in France. This action involves the reprocessing and recycling of plutonium-rich Mixed OXide (MOX) spent fuel, which implies the adaptation of current technologies, in particular dissolution. Therefore, an experimental study of the reaction between uranium-plutonium mixed oxides and nitric acid coupled with chemical reactor modelling is required. In this context, a study of the dissolution of three mixed oxides (30, 40, and 65% Pu/(U+Pu)) and plutonium dioxide in nitric acid is carried out using an optical setup. It can be highlighted that the mixed oxide dissolves according to a similar mechanism as plutonium dioxide when the plutonium content in the solid exceeds 30%. Moreover, only the mixed oxide with the highest uranium content undergoes an autocatalytic reaction mechanism similar to that identified for uranium dioxide. A dissolution model describing the size evolution of a single particle against time was developed. Such model considers the description of particles surface by a fractal geometry approach as well as the surface where the reaction actually takes place. Model was validated by comparison of experimental data from this work and from literature. In addition, a second model was developed, taking into account the single particlemodel, based on population balance equations. The model allows to describe the behaviour of a fluidised bed dissolver, which presents interesting advantages for solid-fluid type reactions. Finally, by implementing the developed model, simulations were performed showing a first estimation of the feasibility of a new dissolution process for current and upcoming MOX fuels

8

Bettini, Eleonora. "Influence of carbides and nitrides on corrosion initiation of advanced alloys : A local probing study". Doctoral thesis, KTH, Yt- och korrosionsvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-129356.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Abstract (sommario):

Advanced alloys often present precipitated carbides and nitrides in their microstructure following exposure to elevated temperatures. These secondary phases are usually undesirable, because potentially deleterious for the corrosion and mechanical performances of the material. Carbides and nitrides are enriched in key alloying elements that are subtracted from their surrounding matrix areas, creating alloying element depleted zones, which might become initial sites for corrosion initiation. In this study, the influence of micro- and nano-sized precipitated carbides and nitrides on the corrosion initiation of biomedical CoCrMo alloys and duplex stainless steels has been investigated at microscopic scale, by using a combination of local probing techniques. The microstructures of the alloys were first characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and magnetic force microscopy (MFM). The Volta potential mapping of carbides and nitrides revealed their higher nobility compared to the matrix, and particularly compared to their surrounding areas, suggesting the occurrence of some alloying element depletion in the latter locations, which may lead to a higher susceptibility for corrosion initiation. In-situ electrochemical AFM studies performed at room temperature showed passive behavior for large potential ranges for both alloy families, despite the presence of the precipitated carbides or nitrides. At high anodic applied potential, at which transpassive dissolution occurs, preferential dissolution started from the areas adjacent to the precipitated carbides and nitrides, in accordance with the Volta potential results. Thus, the presence of carbides and nitrides doesn’t largely affect the corrosion resistance of the tested advanced alloys, which maintain passive behavior when exposed to highly concentrated chloride solutions at room temperature with no applied potential. The effect of nitrides on the corrosion initiation of duplex stainless steels was investigated also at temperatures above the critical pitting temperature (CPT). Depending on the type, distribution and size range of the precipitated nitrides different corrosion behaviors were observed. Intragranular (quenched-in) nano-sized nitrides (ca. 50-100 nm) finely dispersed in the ferrite grains have a minor influence on the corrosion resistance of the material at temperatures above the CPT, while larger intergranular (isothermal) nitrides (ca. 80-250 nm) precipitated along the phase boundaries cause a detrimental reduction of the corrosion resistance of the material, in particular of the austenite phase

QC 20130927

9

Lang, Bo 1986. "Advanced formulation and processing technologies in the oral delivery of poorly water-soluble drugs". Thesis, 2013. http://hdl.handle.net/2152/26092.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Abstract (sommario):

With the advance of combinational chemistry and high throughput screening, an increasing number of pharmacologically active compounds have been discovered and developed. A significant proportion of those drug candidates are poorly water-soluble, thereby exhibiting limited absorption profiles after oral administration. Therefore, advanced formulation and processing technologies are demanded in order to overcome the biopharmaceutical limits of poorly water-soluble drugs. A number of pharmaceutical technologies have been investigated to address the solubility issue, such as particle size reduction, salt formation, lipid-based formulation, and solubilization. Within the scope of this dissertation, two of the pharmaceutical technologies were investigated names thin film freezing and hot-melt extrusion. The overall goal of the research was to improve the oral bioavailability of poorly water-soluble drugs by producing amorphous solid dispersion systems with enhanced wetting, dissolution, and supersaturation properties. In Chapter 1, the pharmaceutical applications of hot-melt extrusion technology was reviewed. The formulation and process development of hot-melt extrusion was discussed. In Chapter 2, we investigated the use of thin film freezing technology combined with template emulsion system to improve the dissolution and wetting properties of itraconazole (ITZ). The effects of formulation variables (i.e., the selection of polymeric excipients and surfactants) and process variables (i.e., template emulsion system versus cosolvent system) were studied. The physic-chemical properties and dissolution properties of thin film freezing compositions were characterized extensively. In Chapter 3 and Chapter 4, we investigated hot-melt extrusion technology for producing amorphous solid dispersion systems and improving the dissolution and absorption of ITZ. Formulation variables (i.e., the selection of hydrophilic additives, the selection of polymeric carriers) and process variables (i.e., the screw configuration of hot-melt extrusion systems) were investigated in order to optimize the performance of ITZ amorphous solid dispersions. The effects of formulation and process variables on the properties of hot-melt extrusion compositions were investigated. In vivo studies revealed that the oral administration of advanced ITZ amorphous solid dispersion formulations rendered enhanced oral bioavailability of the drug in the rat model. Results indicated that novel formulation and processing technologies are viable approaches for enhancing the oral absorption of poorly water-soluble drugs.
text

10

Pereira, Andreia Filipa Dias. "Understanding colloidal speciation events of ASDs through advanced screening tools". Master's thesis, 2019. http://hdl.handle.net/10362/89618.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Abstract (sommario):

Biopharmaceutics Classification System (BCS) class II and IV drugs may be formulated as supersaturating drug delivery systems (e.g., amorphous solid dispersions [ASDs]). The mechanisms that contribute to the increased bioavailability of these systems are generally attributed to the increased solubility of the amorphous form but another mechanism, with significant contributions to the improved bioavailability has been recently identified. This mechanism is related with the formation of colloidal species that are able to improve the bioavailability several fold beyond that of the amorphous drug alone. These species occur when the concentration of drug generated in solution exceeds the amorphous solubility during dissolution, resulting in a liquid-liquid phase separation (LLPS). This work intended to implement a screening methodology to understand the ability of a drug to form colloidal species in a biorelevant dissolution media. This screening strategy was therefore focused on following the colloidal formation of itraconazole (ITZ; model drug from BCS class II) in the presence of hydroxypropyl methylcellulose acetate succinate (HPMC-AS) L, HPMC-AS M and HPMC-AS H (HPMC-AS with varying ratios of succinoyl:acetyl groups), using UV absorbance and a laser diffraction-based methodology. The ability of ITZ to form colloids by a solvent-shift approach was compared with the actual colloidal formation of ITZ amorphous solid dispersions produced by spray-drying (SDD). Results indicate that regardless of the used methodology to form supersaturated solutions of ITZ, colloids could be detected and monitored. The extension of colloid generation showed to be correlated with the SDD disintegration/dissolution rate, i.e, polymers with faster wettability kinetics led to faster SDD disintegration and colloidal formation. As conclusion, this study showed that both laser diffraction and UV absorbance could give complementary information about colloidal formation and SDD dissolution profile, showing to be an excellent screening strategy to be applied in the early stage development of amorphous solid dispersions.

Libri sul tema "Advanced dissolution":

1

Stratigakos, Despina, Andrew Wallace-Hadrill, Katherine L. French, Amanda Flather, Clive Edwards, Jane Hamlett, Despina Stratigakos e Joanne Berry, a cura di. A Cultural History of the Home in the Modern Age. Bloomsbury Publishing Plc, 2021. http://dx.doi.org/10.5040/9781474207188.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Abstract (sommario):

In the last century, our understandings of home have changed profoundly in the wake of revolutionary new technologies and communications, medical advances, global wars and migration, celebrity and consumer cultures, liberation movements, and redefinitions of marriage and family. The rapidity of social transformation in this era has evoked feelings of possibility in the disruption of norms, but also of unease in the dissolution of traditions. These changes have also challenged dominant ideologies of private and public spheres and revealed the porous boundaries between home and the world beyond. The essays in this volume explore the home’s centrality in debates since the end of the First World War about our identities, resources, hopes, and anxieties as individuals and communities. In their analyses of the complexity and elusiveness of meanings of home, the physical materiality of the home – its objects, spaces, and layout – comes under close scrutiny.

2

Marandiuc, Natalia. The Goodness of Home. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780190674502.001.0001.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Abstract (sommario):

The question of what home means and how it relates to subjectivity has fresh urgency in light of pervasive contemporary migration, which ruptures the human self, and painful relational poverty, which characterizes much of modern life. Yet the Augustinian heritage that situates true home and right attachment outside this world has clouded theological conceptualizations of earthly belonging. This book engages this neglected topic and argues for the goodness of home, which it construes relationally rather than spatially. In dialogue with research in the neuroscience of attachment theory and contemporary constructions of the self, the book advances a theological argument for the function of love attachments as sources of subjectivity and enablers of human freedom. The book shows that paradoxically the depth of human belonging—thus, dependence—is directly proportional to the strength of human agency—hence, independence. Building on Søren Kierkegaard’s imagery alongside other sources, the book depicts human love as interwoven with the infinite streams of divine love, forming a sacramental site for God’s presence, and playing a constitutive role in the making of the self. The book portrays the self both as gifted from God in inchoate form and as engaged in continuous, albeit nonlinear becoming via experiences of human love. The Holy Spirit indwells the attachment space between human beings as a middle term preventing its implosion or dissolution and conferring a stability that befits the concept of home. The interstitial space between loving human persons subsists both anthropologically and pneumatologically and generates the self’s home.

Capitoli di libri sul tema "Advanced dissolution":

1

Bojarevics, V., e M. Dupuis. "Advanced Alumina Dissolution Modelling". In Light Metals 2022, 339–48. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92529-1_47.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

2

Seo, Dong Seok, Hwan Kim e Jong Kook Lee. "Preparation of Biologically Derived Hydroxyapatite and its Dissolution". In Advanced Biomaterials VII, 657–60. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.657.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

3

Vermolen, F. J., K. Vuik e S. van der Zwaag. "Advanced Models for Particle Dissolution in Multi-Component Alloys". In Solid State Transformation and Heat Treatment, 53–60. Weinheim, FRG: Wiley-VCH Verlag GmbH & Co. KGaA, 2005. http://dx.doi.org/10.1002/3527604839.ch7.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

4

Seo, Dong Seok, Dae Sung Song e Jong Kook Lee. "Dissolution of Calcium Phosphate Powders with Different Compositions in Simulated Body Fluid". In Advanced Biomaterials VII, 653–56. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.653.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

5

Lee, Jong Kook, Dae Sung Song, Kyu Hong Hwang e Dong Seok Seo. "Effect of Ca/P Ratio on the Dissolution of Calcium Phosphate Powders". In Advanced Biomaterials VII, 661–64. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.661.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

6

Sharma, Mukesh, e Neslihan Dogan. "Comparison of Dissolution Kinetics of Nonmetallic Inclusions in Steelmaking Slag". In Advanced Real Time Imaging II, 119–27. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-06143-2_12.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

7

Youn, Sang Heum, Z. X. Yang, Kyu Hong Hwang, Jong Kook Lee e Seog Young Yoon. "Effect of Glass Phase on the Defect Formation during the Dissolution of Hydroxyapatite". In Advanced Biomaterials VII, 637–40. Stafa: Trans Tech Publications Ltd., 2007. http://dx.doi.org/10.4028/0-87849-436-7.637.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

8

Abdeyazdan, Hamed, Neslihan Dogan, Raymond J. Longbottom, M. Akbar Rhamdhani, Michael W. Chapman e Brian J. Monaghan. "Dissolution of Sapphire and Alumina–Magnesia Particles in CaO–SiO2–Al2O3 Liquid Slags". In Advanced Real Time Imaging II, 61–73. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-06143-2_7.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

9

Kumar, K., I. S. Pop e F. A. Radu. "Numerical Analysis for an Upscaled Model for Dissolution and Precipitation in Porous Media". In Numerical Mathematics and Advanced Applications 2011, 703–11. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-33134-3_74.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

10

Cai, Yurong, L. Zhou, Jianhua Wei, Zhentao Yu e Jin Long Niu. "In Vitro Dissolution Behavior of Gel-Derived Bioactive Glasses in the SiO₂-CaO-P₂O₅-MgO System". In Advanced Biomaterials VI, 541–44. Stafa: Trans Tech Publications Ltd., 2005. http://dx.doi.org/10.4028/0-87849-967-9.541.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Atti di convegni sul tema "Advanced dissolution":

1

Chauhan, Siddharth, Mark Somervell, Michael Carcasi, Steven Scheer, Roger T. Bonnecaze, Chris Mack e C. Grant Willson. "Particle generation during photoresist dissolution". In SPIE Advanced Lithography, a cura di Robert D. Allen. SPIE, 2010. http://dx.doi.org/10.1117/12.848424.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

2

Itani, Toshiro, e Julius Joseph Santillan. "In situ dissolution analysis of EUV resists". In SPIE Advanced Lithography, a cura di Robert D. Allen e Mark H. Somervell. SPIE, 2011. http://dx.doi.org/10.1117/12.878670.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

3

Lee, Seung-Hyun, Jong Keun Park, Thomas Cardolaccia, Jibin Sun, Cecily Andes, Kathleen O'Connell e George G. Barclay. "Understanding dissolution behavior of 193nm photoresists in organic solvent developers". In SPIE Advanced Lithography, a cura di Mark H. Somervell e Thomas I. Wallow. SPIE, 2012. http://dx.doi.org/10.1117/12.918045.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

4

Toriumi, Minoru, Fumihiko Okabe e Masahiko Kitayama. "Dissolution behavior of resist polymers studied by Quartz-Crystal-Microbalance method II". In Advanced Lithography, a cura di Qinghuang Lin. SPIE, 2007. http://dx.doi.org/10.1117/12.711926.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

5

Rao, Ashwin, Shuhui Kang, Bryan D. Vogt, Vivek M. Prabhu, Eric K. Lin, Wen-Li Wu, Karen Turnquest e William D. Hinsberg. "Dissolution fundamentals of 193-nm methacrylate based photoresists". In SPIE 31st International Symposium on Advanced Lithography, a cura di Qinghuang Lin. SPIE, 2006. http://dx.doi.org/10.1117/12.656540.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

6

Fonseca, Carlos, Brian Head, Hideo Shite, Kathleen Nafus, Roel Gronheid e Gustaf Winroth. "Understanding EUV resist dissolution characteristics and its impact to RLS limitations". In SPIE Advanced Lithography, a cura di Bruno M. La Fontaine e Patrick P. Naulleau. SPIE, 2011. http://dx.doi.org/10.1117/12.879449.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

7

Chauhan, Siddharth, Mark Somervell, Steven Scheer, Chris A. Mack, Roger T. Bonnecaze e C. Grant Willson. "Polymer dissolution model: an energy adaptation of the critical ionization theory". In SPIE Advanced Lithography, a cura di Clifford L. Henderson. SPIE, 2009. http://dx.doi.org/10.1117/12.814344.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

8

Yoshizawa, Fatima, Ekaterina Burov, Anne-Céline Garel-Laurin e Michael Toplis. "Advanced confocal Raman spectroscopy applied to high temperature dissolution problems". In Goldschmidt2023. France: European Association of Geochemistry, 2023. http://dx.doi.org/10.7185/gold2023.16986.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

9

Im, Kwanghwyi, Jin Jegal, Jungkook Park, Deogbae Kim e Jaehyun Kim. "Resist dissolution behavior according to protecting group in polymer". In SPIE 31st International Symposium on Advanced Lithography, a cura di Qinghuang Lin. SPIE, 2006. http://dx.doi.org/10.1117/12.655458.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

10

Takeshi, Kazumasa, Kazuto Oono, Yoshiyuki Negishi, Daisuke Inokuchi, Keishi Tanaka e Akira Tamura. "Dissolution behavior of chemically amplified resist for advanced mask- and NIL mold-making as studied by dissolution rate monitor". In Photomask and Next Generation Lithography Mask Technology XIII, a cura di Morihisa Hoga. SPIE, 2006. http://dx.doi.org/10.1117/12.681763.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Rapporti di organizzazioni sul tema "Advanced dissolution":

1

Chefetz, Benny, Baoshan Xing, Leor Eshed-Williams, Tamara Polubesova e Jason Unrine. DOM affected behavior of manufactured nanoparticles in soil-plant system. United States Department of Agriculture, gennaio 2016. http://dx.doi.org/10.32747/2016.7604286.bard.

Testo completo

Gli stili APA, Harvard, Vancouver, ISO e altri

Abstract (sommario):

The overall goal of this project was to elucidate the role of dissolved organic matter (DOM) in soil retention, bioavailability and plant uptake of silver and cerium oxide NPs. The environmental risks of manufactured nanoparticles (NPs) are attracting increasing attention from both industrial and scientific communities. These NPs have shown to be taken-up, translocated and bio- accumulated in plant edible parts. However, very little is known about the behavior of NPs in soil-plant system as affected by dissolved organic matter (DOM). Thus DOM effect on NPs behavior is critical to assessing the environmental fate and risks related to NP exposure. Carbon-based nanomaterials embedded with metal NPs demonstrate a great potential to serve as catalyst and disinfectors. Hence, synthesis of novel carbon-based nanocomposites and testing them in the environmentally relevant conditions (particularly in the DOM presence) is important for their implementation in water purification. Sorption of DOM on Ag-Ag₂S NPs, CeO₂ NPs and synthesized Ag-Fe₃O₄-carbon nanotubebifunctional composite has been studied. High DOM concentration (50mg/L) decreased the adsorptive and catalytic efficiencies of all synthesized NPs. Recyclable Ag-Fe₃O₄-carbon nanotube composite exhibited excellent catalytic and anti-bacterial action, providing complete reduction of common pollutants and inactivating gram-negative and gram-positive bacteria at environmentally relevant DOM concentrations (5-10 mg/L). Our composite material may be suitable for water purification ranging from natural to the industrial waste effluents. We also examined the role of maize (Zeamays L.)-derived root exudates (a form of DOM) and their components on the aggregation and dissolution of CuONPs in the rhizosphere. Root exudates (RE) significantly inhibited the aggregation of CuONPs regardless of ionic strength and electrolyte type. With RE, the critical coagulation concentration of CuONPs in NaCl shifted from 30 to 125 mM and the value in CaCl₂ shifted from 4 to 20 mM. This inhibition was correlated with molecular weight (MW) of RE fractions. Higher MW fraction (> 10 kDa) reduced the aggregation most. RE also significantly promoted the dissolution of CuONPs and lower MW fraction (< 3 kDa) RE mainly contributed to this process. Also, Cu accumulation in plant root tissues was significantly enhanced by RE. This study provides useful insights into the interactions between RE and CuONPs, which is of significance for the safe use of CuONPs-based antimicrobial products in agricultural production. Wheat root exudates (RE) had high reducing ability to convert Ag+ to nAg under light exposure. Photo-induced reduction of Ag+ to nAg in pristine RE was mainly attributed to the 0-3 kDa fraction. Quantification of the silver species change over time suggested that Cl⁻ played an important role in photoconversion of Ag+ to nAg through the formation and redox cycling of photoreactiveAgCl. Potential electron donors for the photoreduction of Ag+ were identified to be reducing sugars and organic acids of low MW. Meanwhile, the stabilization of the formed particles was controlled by both low (0-3 kDa) and high (>3 kDa) MW molecules. This work provides new information for the formation mechanism of metal nanoparticles mediated by RE, which may further our understanding of the biogeochemical cycling and toxicity of heavy metal ions in agricultural and environmental systems. Copper sulfide nanoparticles (CuSNPs) at 1:1 and 1:4 ratios of Cu and S were synthesized, and their respective antifungal efficacy was evaluated against the pathogenic activity of Gibberellafujikuroi(Bakanae disease) in rice (Oryza sativa). In a 2-d in vitro study, CuS decreased G. fujikuroiColony- Forming Units (CFU) compared to controls. In a greenhouse study, treating with CuSNPs at 50 mg/L at the seed stage significantly decreased disease incidence on rice while the commercial Cu-based pesticide Kocide 3000 had no impact on disease. Foliar-applied CuONPs and CuS (1:1) NPs decreased disease incidence by 30.0 and 32.5%, respectively, which outperformed CuS (1:4) NPs (15%) and Kocide 3000 (12.5%). CuS (1:4) NPs also modulated the shoot salicylic acid (SA) and Jasmonic acid (JA) production to enhance the plant defense mechanisms against G. fujikuroiinfection. These results are useful for improving the delivery efficiency of agrichemicals via nano-enabled strategies while minimizing their environmental impact, and advance our understanding of the defense mechanisms triggered by the NPs presence in plants.