Letteratura scientifica selezionata sul tema "92C60"
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Articoli di riviste sul tema "92C60":
1
Harianto, Joko, e Inda Puspita Sari. "ANALISIS KESTABILAN LOKAL TITIK EKUILIBRIUM MODEL EPIDEMI SEIV DENGAN PERTUMBUHAN LOGISTIK". Majalah Ilmiah Matematika dan Statistika 22, n. 1 (23 marzo 2022): 59. http://dx.doi.org/10.19184/mims.v22i1.30174.
Abstract (sommario):
The SEIV model uses population growth which is assumed to follow logistical growth. The model is studied then analyzed. The analysis shows that the non-endemic (disease-free) equilibrium point is locally asymptotically stable when the basic reproduction number less than one, while the endemic equilibrium point is locally asymptotically stable when the basic reproduction number greater than one. Then a numerical simulation was carried out using Maple software to support the results of the local stability analysis of the equilibrium point. Based on numerical simulations, it shows that a disease will disappear from the population when the basic reproduction number less than one and for a long time a disease will remain in the population (still an epidemic) when the basic reproduction number greater than one.Keywords: SEIV model, logistical growth, equilibrium point, basic reproduction numberMSC2020: 92C60
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López-González, MJ, E. Rodríguez, G. G. Shepherd, M. G. Shepherd, S. Sargoytchev, V. M. Aushev, M. García-Comas, S. Brown e R. H. Wiens. "O2 Atmospheric band and OH(6–2) airglow and temperature variability over Spain using SATI observations: Planetary-scale oscillations during autumn". Canadian Journal of Physics 85, n. 2 (1 febbraio 2007): 153–72. http://dx.doi.org/10.1139/p07-035.
Abstract (sommario):
Long-term ground-based airglow observations with a spectral airglow temperature imager (SATI) installed at Sierra Nevada Observatory (37.06°N, 3.38°W) at 2900~m height are used to investigate the main features of the quasi planetary waves in the period range of 3–20 days during autumn at this latitude in the mesosphere and lower thermosphere region. The modulations of periods 5 day, (6–7) day, and 10 day have been clearly detected during autumn at this location, being the most prominent waves detected at this location during the autumn. They have a strong persistence during the autumn period and relative amplitudes are generally constant during the period although a slight tendency to increase seems to be detected towards winter.PACS Nos.: 92.60.hw, 92.60.hb, 92.60.hc, 92.60.hh, 92.60.hv
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Pla, Juan. "92.60 Linear recurrences which produce Pythagorean triples". Mathematical Gazette 92, n. 525 (novembre 2008): 482–85. http://dx.doi.org/10.1017/s002555720018369x.
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Haley, C. S., e S. Brohede. "Status of the Odin/OSIRIS stratospheric O3 and NO2 data products". Canadian Journal of Physics 85, n. 11 (1 novembre 2007): 1177–94. http://dx.doi.org/10.1139/p07-114.
Abstract (sommario):
This paper describes the status of the stratospheric ozone and nitrogen dioxide data products from the Optical Spectrograph and InfraRed Imager System (OSIRIS) instrument on the Odin satellite. The current version of the data products is 3.0, covering the period from November 2001 to the present. The O3 and NO2 retrieval methods are reviewed along with an overview of the error analyses and geophysical validation status. PACS Nos.: 07.05.Kf, 07.87.+v, 42.68.Mj, 92.60.hd, 92.60.Ta, 92.60.Vb, 92.70.Cp, 95.75.Fg, 95.75.Rs
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Rajagopal, H., P. U. M. Sastry, A. Sequeira e P. Ramasamy. "Single-crystal neutron diffraction study of ferroelectric Ba0·92Ca0·08TiO3". Bulletin of Materials Science 17, n. 3 (giugno 1994): 201–4. http://dx.doi.org/10.1007/bf02745170.
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Petelina, S. V., E. J. Llewellyn e D. A. Degenstein. "Properties of polar mesospheric clouds measured by Odin/OSIRIS in the northern hemisphere in 2002–2005". Canadian Journal of Physics 85, n. 11 (1 novembre 2007): 1143–58. http://dx.doi.org/10.1139/p07-092.
Abstract (sommario):
Interseasonal variations in the properties of Polar Mesospheric Clouds (PMC) measured by the Optical Spectrograph and InfraRed Imager System (OSIRIS) on the Odin satellite during the northern hemisphere (NH) summers of 2002–2005 are described in this work. The lowest PMC latitudes were about 50°N for every season with the number of detections smallest in 2002 and largest in 2004. In 2004 and 2005, the detection of PMCs at lower latitudes was asymmetric with the larger number of clouds observed during the first half and fewer at during the second half of the season. PMC occurrence frequency in 2002 was 25–30% lower than in 2003–2005, and the season duration was shortest in 2002 and longest in 2004. For all NH seasons except 2002, PMC occurrence frequency was systematically 20–50% higher than the Solar Mesosphere Explorer climatology. Similar to PMC occurrence frequency, cloud brightness was lowest in 2002 and highest in 2004 at all latitudes. The daily mean brightness maximum at 50°–60°N was less than 8% of that at highest latitudes. This contrasts with the maximum PMC occurrence frequency that reached nearly 30% at these latitudes in 2004 and 2005. PMC brightness showed no apparent seasonal asymmetry at lower latitudes in 2004 and 2005 that was seen in the occurrence frequency. Significant, by about a factor of 2, oscillations observed in the daily mean cloud brightness at high latitudes were also not seen in the corresponding occurrence frequency. These results suggest that the occurrence frequency alone does not provide detailed information on the cloud population and ice mass in the mesosphere. There is no significant interannual variability in the seasonal mean OSIRIS PMC altitude. Its value was very close to 8350 km for all seasons except 2004 when it was 83.42 km. The mean PMC altitudes for each season increased by 0.3–0.6 when the minimum altitude in the database was increased from 80 to 82 km. PACS Nos.: 92.05.Fg, 92.60.hc, 92.60.Jq, 92.60.Mt, 92.60.Nv, 92.60.Vb
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Wardani, Ayu Pramudita, Eri Witcahyo e Sri Utami. "Efektivitas Biaya Program Pengelolaan Penyakit Kronis (Prolanis) di Puskesmas". HIGEIA (Journal of Public Health Research and Development) 2, n. 4 (31 ottobre 2018): 622–33. http://dx.doi.org/10.15294/higeia.v2i4.20763.
Abstract (sommario):
Abstrak
Biaya yang dihabiskan untuk penyakit katastropik hingga semester I tahun 2017 telah mencapai Rp 12,7 trilliun atau 24,81% dari total biaya rumah sakit. Jumlah peserta Prolanis Puskesmas Karangduren sebanyak 46 peserta dengan RPPRB sebesar 92,60% dan Patrang sebanyak 45 orang dengan RPPRB sebesar 42,96%. Tujuan penelitian ini adalah menganalisis efektivitas biaya Prolanis pada Puskesmas Karangduren dan Patrang. Jenis penelitian ini adalah deskriptif. Penelitian dilakukan pada bulan September 2017 sampai dengan Oktober 2017. Data diperoleh dengan studi dokumentasi dan wawancara pada penanggung jawab Prolanis, bagian keuangan JKN dan tata usaha. Hasil penelitian menunjukkan input Prolanis pada Puskesmas Karangduren dan Patrang yakni ketersediaan SDM dan dana untuk Prolanis yang tidak keluar, serta kegiatan home visit belum terlaksana karena tidak adanya dana untuk transport petugas dan kurangnya SDM home visit. Hanya peserta Prolanis Puskesmas Patrang dengan riwayat hipertensi telah mencapai indikator 75%. Simpulan penelitian ini adalah efektivitas biaya Prolanis Puskesmas Karangduren lebih efektif dibandingkan Puskesmas Patrang.
Abstract
The cost was spent for catastrophic disease until first semester of 2017 have reached Rp 12.7 trillion or 24.81% of the total cost hospital. The amount participants of Prolanis Karangduren primary health care was 46 participants with RPPRB of 92.60% and Patrang was 45 participants with RPPRB of 42.96%. The purpose of this study was to analyze the cost effectiveness of Prolanis at Karangduren and Patrang primary health care. The study was a descriptive design. This study was conducted from September until October 2017. Data was collected by documentation and interview of Prolanis officer, finance JKN and administration staff. The results showed Prolanis input on Karangduren and Patrang primary health care were the availability of human resources and the fund that do come out,, and home visit activity had not been done yet. Only Prolanis participants of Patrang primary health care with the history of hypertension has reached 75% indicator every month. The cost effectiveness Prolanis Karangduren primary health care more effective was compared to Patrang primary health care.
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Sioris, C. E., S. Chabrillat, C. A. McLinden, C. S. Haley, Y. J. Rochon, R. Ménard, M. Charron e C. T. McElroy. "OSIRIS observations of a tongue of NOx in the lower stratosphere at the Antarctic vortex edge: comparison with a high-resolution simulation from the Global Environmental Multiscale (GEM) model". Canadian Journal of Physics 85, n. 11 (1 novembre 2007): 1195–207. http://dx.doi.org/10.1139/p07-123.
Abstract (sommario):
Selected NOx profiles of the Antarctic lower stratosphere inferred from OSIRIS NO2 observations are presented from the austral spring of 2003. These observations show a tongue of NOx at 100 hPa, with a concentration typical of the middle stratosphere. Simulations with the Global Environmental Multiscale model show that this small-scale tongue of NOx-rich air descended into the lower stratosphere. The tongue was formed as a result of a Rossby wave breaking days earlier, transporting NOx from the pole, where larger concentrations had recently appeared, to the edge of the vortex. The three-dimensional structure of the breaking wave is illustrated in detail. PACS Nos.: 92.60.hf, 92.60.Xg, 93.30.Ca
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Roth, C. Z., D. A. Degenstein, A. E. Bourassa e E. J. Llewellyn. "The retrieval of vertical profiles of the ozone number density using Chappuis band absorption information and a multiplicative algebraic reconstruction technique". Canadian Journal of Physics 85, n. 11 (1 novembre 2007): 1225–43. http://dx.doi.org/10.1139/p07-130.
Abstract (sommario):
A new algorithm, SaskMART, is presented that uses observations of limb-scattered sunlight and a radiative transfer model to determine the ozone number-density profile up to 35 km altitude. In practice, clouds limit the lower extent of the retrieval to around 15 km but if the troposphere is clear the retrieval can be extended to altitudes as low as 10 km. SaskMART is an iterative Multiplicative Algebraic Reconstruction Technique that generates accurate results and is insensitive to the initial estimate of the ozone profile. Examples are presented using the OSIRIS limb-scattered radiance measurements and good agreement has been found when these results are compared with those derived from SAGE II measurements. PACS Nos.: 33.20.Kf, 33.20.Lg, 42.68.Ca, 42.68.Mj, 92.60.H–, 92.60.hd
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Gattinger, R. L., D. A. Degenstein, E. J. Llewellyn e M. H. Stevens. "OH A2Σ+ –X2Π band ratios observed in the mesosphere by OSIRIS". Canadian Journal of Physics 86, n. 7 (1 luglio 2008): 857–62. http://dx.doi.org/10.1139/p08-015.
Abstract (sommario):
In this study, we present spectra of the mesospheric OH A2Σ+ –X2Π band system, including the 0–0, 1–1, and 1–0 bands, as observed by OSIRIS (Optical Spectrograph and Infrared Imaging System). Spectral components due to Rayleigh-scattered sunlight, lower thermospheric dayglow emission features, and baffle scatter have been removed to isolate the OH emission signature. The observed spectra are compared with model spectra assembled using rotational emission rate factors for solar resonance fluorescence (g-factors) plus prompt emission of the OH A2Σ+ –X2Π band system from solar Lyman-α photodissociation of water. The observed band ratios are in good agreement with the model values. The altitude variation of the 0–0 band, relative to the 1–1 band, is in agreement with model predictions based on vibrational energy transfer from OH A2Σ+ ν′ = 1 to OH A2Σ+ ν′ = 0. This detailed understanding of the OH A2Σ+ –X2Π system is critical for the successful application of OH observations to the determination of mesospheric OH densities and water vapor concentrations.PACS Nos.: 33.20.Lg, 33.20.Tp, 33.70.Fd, 92.60.hc, 92.60.hw
Tesi sul tema "92C60":
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Youssfi, Younès. "Exploring Risk Factors and Prediction Models for Sudden Cardiac Death with Machine Learning". Electronic Thesis or Diss., Institut polytechnique de Paris, 2023. http://www.theses.fr/2023IPPAG006.
Abstract (sommario):
La mort subite de l'adulte est définie comme une mort inattendue sans cause extracardiaque évidente, survenant avec un effondrement rapide en présence d'un témoin, ou en l'absence de témoin dans l'heure après le début des symptômes. Son incidence est estimée à 350,000 personnes par an en Europe et 300,000 personnes aux Etats-Unis, ce qui représente 10 à 20% des décès dans les pays industrialisés. Malgré les progrès réalisés dans la prise en charge, le pronostic demeure extrêmement sombre. Moins de 10% des patients sortent vivants de l'hôpital après la survenue d'une mort subite. Les défibrillateurs automatiques implantables offrent une solution thérapeutique efficace chez les patients identifiés à haut risque de mort subite. Leur identification en population générale demeure donc un enjeu de santé publique majeur, avec des résultats jusqu'à présent décevants. Cette thèse propose des outils statistiques pour répondre à ce problème, et améliorer notre compréhension de la mort subite en population générale. Nous analysons les données du Centre d'Expertise de la Mort Subite et les bases médico-administratives de l'Assurance Maladie, pour développer trois travaux principaux :- La première partie de la thèse vise à identifier de nouveaux sous-groupes de mort subite pour améliorer les modèles actuels de stratification du risque, qui reposent essentiellement sur des variables cardiovasculaires. Nous utilisons des modèles d'analyse du langage naturel et de clustering pour construire une nouvelle représentation pertinente de l'historique médical des patients.- La deuxième partie vise à construire un modèle de prédiction de la mort subite, capable de proposer un score de risque personnalisé et explicable pour chaque patient, et d'identifier avec précision les individus à très haut risque en population générale. Nous entraînons pour cela un algorithme de classification supervisée, combiné avec l'algorithme SHapley Additive exPlanations, pour analyser l'ensemble des consommations de soin survenues jusqu'à 5 ans avant l'événement.- La dernière partie de la thèse vise à identifier le niveau optimal d'information à sélectionner dans des bases médico-administratives de grande dimension. Nous proposons un algorithme de sélection de variables bi-niveaux pour des modèles linéaires généralisés, permettant de distinguer les effets de groupe des effets individuels pour chaque variable. Cet algorithme repose sur une approche bayésienne et utilise une méthode de Monte Carlo séquentiel pour estimer la loi a posteriori de sélection des variablesSudden cardiac death (SCD) is defined as a sudden natural death presumed to be of cardiac cause, heralded by abrupt loss of consciousness in the presence of witness, or in the absence of witness occurring within an hour after the onset of symptoms. Despite progress in clinical profiling and interventions, it remains a major public health problem, accounting for 10 to 20% of deaths in industrialised countries, with survival after SCD below 10%. The annual incidence is estimated 350,000 in Europe, and 300,000 in the United States. Efficient treatments for SCD management are available. One of the most effective options is the use of implantable cardioverter defibrillators (ICD). However, identifying the best candidates for ICD implantation remains a difficult challenge, with disappointing results so far. This thesis aims to address this problem, and to provide a better understanding of SCD in the general population, using statistical modeling. We analyze data from the Paris Sudden Death Expertise Center and the French National Healthcare System Database to develop three main works:- The first part of the thesis aims to identify new subgroups of SCD to improve current stratification guidelines, which are mainly based on cardiovascular variables. To this end, we use natural language processing methods and clustering analysis to build a meaningful representation of medical history of patients.- The second part aims to build a prediction model of SCD in order to propose a personalized and explainable risk score for each patient, and accurately identify very-high risk subjects in the general population. To this end, we train a supervised classification algorithm, combined with the SHapley Additive exPlanation method, to analyze all medical events that occurred up to 5 years prior to the event.- The last part of the thesis aims to identify the most relevant information to select in large medical history of patients. We propose a bi-level variable selection algorithm for generalized linear models, in order to identify both individual and group effects from predictors. Our algorithm is based on a Bayesian approach and uses a Sequential Monte Carlo method to estimate the posterior distribution of variables inclusion
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Clough, Matthew. "Defect screening of pipelines using circumferential guided waves". Thesis, University of Warwick, 2016. http://wrap.warwick.ac.uk/92360/.
Abstract (sommario):
A system for the shear horizontal guided wave screening of pipelines is developed and optimised. The system is considered in terms of the circumferential shear horizontal guided wave behaviour as opposed to the majority of other studies that approximate the structure of an unwrapped pipe as a plate. This allows for consideration of the effect of a defect on both the lowest order symmetric and antisymmetric modes. The assessment of the guided wave interaction with a corrosion patch defect is carried out for a basic defect from which the axial sizing can be determined from encoded scans of the sample and amplitude changes. The circumferential positioning capabilities can be found using the effect seen on different modes and the presence of reflections. The behaviour of the two lowest order shear horizontal modes when incident on a defect above and below the cut off thickness of the lowest order antisymmetric mode can be seen in the experimental measurements and visualised through finite element modelling. Once the behaviour of the modes when they interact with different depths of a defect is understood, the technique is expanded to a real corrosion patch of known dimensions. It is extended to more complex samples with multiple, varied positioned corrosion patches and blind trial situations where the geometry and depth of defects is unknown. Although the size and depth of these defects is unknown, the knowledge of the interaction of the waves with the other defects can be used to estimate the defect size and depth. The calculation of the remaining wall thickness in the current iteration of the system is limited to a broad range, unless there is prior knowledge of the defect geometry. This is because the defect geometry is shown to have a large effect on the arrival time of the through transmitted waves. Consideration is given to the effect of welds on a signal and the differences between calibration defects and real corrosion patch style defects. The system has been tested further in extended blind trials and proved effective as a screening tool for the detection of corrosion patch style defects, with detection capabilities dependent on the axial size and depth of the defect.
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Montanari, Silvia. "Sinergia di processi chimico-fisici per la riqualificazione di acque contaminate da composti organici". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9260/.
Abstract (sommario):
L’acqua è una delle risorse critiche del pianeta e l’acqua dolce accessibile all’uomo rappresenta meno dell’1% delle risorse idriche; da questi numeri si capisce quanto siano importanti la prevenzione dell’inquinamento ambientale e i processi di depurazione delle acque reflue. A partire dagli anni ’70, grazie anche al miglioramento delle tecniche analitiche, sono iniziati monitoraggi degli inquinanti nelle acque superficiali e sotterranee e sono state riscontrate concentrazioni di inquinanti, i cui effetti di tossicità cronica sull’uomo e l’ecosistema non sempre sono trascurabili. Inoltre si è rilevato che alcune molecole di sintesi sono difficilmente biodegradabili e non sono mineralizzate con i trattamenti convenzionali di depurazione; perciò l’Unione Europea ha emanato delle direttive per preservare le risorse idriche in cui è contenuto un elenco di sostanze prioritarie, per le quali sono stati fissati gli standard di qualità ambientale. Nel 2013 è stata anche istituita una watch list che contiene dieci sostanze sulle quali raccogliere dati di monitoraggio ambientale e effetti sugli ecosistemi. Di qui la ricerca costante di nuovi trattamenti di depurazione delle acque, tra i quali i processi di ossidazione avanzata attirano molto interesse perché promettono di mineralizzare i composti bio-recalcitranti senza produrre fanghi da smaltire o sottoprodotti pericolosi. Oggetto della presente tesi sperimentale, svolta presso il Consiglio Nazionale delle Ricerche, nell’Istituto per la Sintesi Organica e la Fotoreattività, è stato lo studio della de-gradazione e mineralizzazione di una miscela di cinque molecole (diclofenac, carbama-zepina, triton X-100, benzofenone-3, benzofenone-4), scelte per le diverse caratteristiche chimico-fisiche, utilizzando radiazione ultravioletta e ultrasuoni, in presenza di biossido di titanio come fotocatalizzatore o perossido d'idrogeno come additivo per produrre radicali idrossile e avviare catene di reazioni ossidative. A partire dai fenomeni fotochimici o fotocatalitici così ottenuti, eventualmente assistiti da ultrasuoni, sono stati studiati gli effetti delle variazioni dei parametri operativi sulla degradazione dei componenti della miscela e sono stati valutati i consumi energetici della strumentazione prototipale per unità di massa del contaminante degradato. La parte sperimentale è stata preceduta da un’accurata ricerca bibliografica riguardo gli effetti di tossicità degli inquinanti ritrovati nelle acque, la legislazione europea ed italiana in materia ambientale e delle acque e i processi di ossidazione avanzata.
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Espona, Fiedler Margarita. "Estudio de los mecanismos moleculares involucrados en las propiedades anticancerosas y antimetastásicas de las prodigininas. Identificación de mTOR como diana molecular en células de melanoma". Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/92560.
Abstract (sommario):
El melanoma metastásico es un modelo de tumor especialmente agresivo y resistente a inmuno, radio y quimioterapia. La pobre prognosis de los pacientes y el preocupante incremento de casos en los últimos años hacen necesario el diseño y desarrollo de nuevos y mejorados agentes anticancerígenos, así como nuevas estrategias más eficaces.
Las células de melanoma presentan alteraciones genéticas y moleculares que alteran el control de la proliferación y supervivencia celular. Estas alteraciones permiten superar las barreras de control del crecimiento y migración celular, aspectos asociados no sólo con la inmortalización y adquisición de las propiedades invasivas, sino que también les confieren resistencia frente a tratamientos quimioterapéuticos.
Tanto la vía PI3K/AKT/mTOR, como la vía mitogénica mediada por MAPKs, son claves en la supervivencia y crecimiento celular. Ambas vías, a través de GSK-3 se encuentran implicadas en la sobreexpresión de proteínas anti-apoptóticas de la familia BCL-2. La sobreexpresión de esta familia de proteínas facilita que la célula escape a los mecanismos apoptóticos inducidos por agentes citotóxicos convencionales. Por esta razón, estrategias terapéuticas basadas en la inhibición de estas vías han mostrado su potencial en estudios clínicos. Este potencial radica en la activación simultánea de dos mecanismos de muerte celular: apoptosis y autofagia.
De entre la familia de compuestos anticancerosos conocidos como prodigininas (PGs), en un principio, prodigiosina destacó por su marcado efecto pro-apoptótico en diferentes líneas tumorales. Actualmente, un derivado sintético de las PGs, obatoclax, que fue diseñado como molécula BH3 mimética, está siendo evaluado en ensayos clínicos en fase III. Sin embargo, los estudios realizados en melanoma muestran la modesta eficacia de obatoclax como agente individual, lo que hacía necesario estudios más exhaustivos sobre los mecanismos de acción de esta molécula. Un efecto citotóxico más marcado se ha obtenido mediante el tratamiento con prodigiosina. A pesar de que ambas moléculas han mostrado desencadenar similares mecanismos moleculares, las diferencias estructurales entre ambas moléculas serían críticas en su actividad. Los nuevos datos aportados contribuyen a un mejor entendimiento de los eventos moleculares que desencadenan la actividad anticancerosa y antimetastásica de las PGs. En este aspecto, la caracterización de PGs como inhibidores duales de mTORC1 y mTORC2 pone en evidencia la relevancia que estas moléculas podrían tener en un futuro en la terapia contra el cáncer. La interacción de PGs al centro activo de mTOR se confirmó mediante técnicas de resonancia de plasmón superficial (SPR), monitorizando las interacciones a tiempo real, usando biosensores ópticos. Los parámetros cinéticos y de afinidad mostraron que ambas moléculas forman complejos estables, específicos, y de alta afinidad a concentraciones nanomolares. Los ensayos de competición con ATP revelaron que no existe competición entre ATP y las PGs por su lugar de unión, sugiriendo que las PGs actúan como inhibidores ATP no miméticos.
Un valor añadido de estas moléculas son sus probadas propiedades antimetastásicas. En este aspecto, demostramos que la inhibición de mTOR promueve la desestabilización del complejo ILK/rictor con la consecuente pérdida de señalización a través de la vía de las integrinas, crítica para el movimiento celular. Observamos que, todo ello conlleva a la desorganización del citoesqueleto, pérdida de los contactos focales y pérdida de la capacidad migratoria de las células.
Finalmente, estrategias análogas fueron utilizadas para llevar a cabo estudios de relación estructura-actividad de las PGs. La estructura tripirrólica de prodigiosina (PG) contiene grupos amino y metoxi comunes en obatoclax (OBX) relacionados con su actividad citotóxica. El bloqueo de estos grupos mediante la adición del grupo aniónico F2B resultó en la pérdida de actividad de esta molécula. Estos resultados ponen de manifiesto la importancia de estos grupos en la actividad de PGs, y aportan nuevos datos para el diseño de nuevos derivados sintéticos más efectivos y menos tóxicos.MECHANISMS OF ACTION INVOLVED IN THE ANTICANCER AND ANTIMETASTATIC PROPERTIES OF PRODIGININES. Identification of mTOR as a molecular target in melanoma cells. Because of high chemotherapeutic resistance of metastatic melanoma are necessary new strategies with improved drugs, more effectives with lower toxicity. Anticancer activity of prodiginines has been described in vitro and in vivo in different cancer cell models, including melanoma. Prodiginines are tripyrrolic molecules from bacterial metabolism under pre-clinical and clinical evaluation. In this study we have focused our efforts on identified the molecular mechanisms of prodiginines involved in their cytotoxic effects. In melanoma cells, we have observed the activation of both cell death mechanisms: apoptosis and autophagy after prodigiosin treatment. Our results demonstrate that prodigiosin is a BH3-mimetic drug, as it was previously described for obatoclax (GX15-070). Obatoclax is a synthetic prodiginine derivative actually in clinical trials in phase III. Moreover, we have identified mTOR as a new molecular target of prodigiosin and obatoclax. PI3K/AKT/mTOR pathway is involved in cell survival, proliferation and migration. Different cross-talks and feedback loops regulate this pathway and, also, are involved in different compensatory mechanisms that confer chemoresistance to melanoma cells. Dual inhibition of mTORC1 and mTORC2 mediated by both prodiginines disrupted the negative feedback loop S6K/IRS-1. The interaction of both prodiginines in the active site of mTOR was monitorized by Surface Plasmon Resonance (SPR) assays. Nanomolar kinetic and affinity parameters indicated high affinity, stability and specificity of these interactions. Nevertheless, results showed that both prodiginines are not ATP-mimetic drugs. In silico models showed the detailed atomic view of the complexes indicating the critical residues involved in these interactions. Moreover, structure-activity relationship (SAR) studies corroborated the importance of pyrrole amino groups in the cytotoxic prodiginines activity mediated by mTOR inhibition. Finally, we observed that mTOR inhibition by prodiginines promotes actin filaments desorganization, decrease of focal adhesions and inhibition of cell migration. Our results suggest that prodiginines might inhibit integrin signalling through ILK/rictor complex. Alltogether, these results contribute to further understanding the molecular mechanisms of prodiginines and, also, their chemotherapeutical potential. Moreover, we provide new data about their structural properties that will allow the development of more-effective anticancer molecules.
5
Farhat, Ian Anderson Guimarães Konopczyk Maluf [UNESP]. "Modificação de superfícies de zircônia empregada a restaurações sem metais". Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/92060.
Abstract (sommario):
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farhat_iagkm_me_araiq.pdf: 1810615 bytes, checksum: 5d9fa6051c33ffc0431648ceddfb8dba (MD5)A Odontologia ainda não apresenta recomendação específica quanto ao tratamento adequado da superfície de cerâmicas a base de zircônia, a fim de melhorar sua adesão à dentina. Esta pesquisa estudou as propriedades Físico- Químicas dos diferentes tratamentos de superfície aplicados a corpos de prova confeccionados em zircônia estabilizados por ítria (Lava Frame Y-TZP, 3M ESPE), utilizados em restaurações sem metais. Foram aplicados diferentes condicionamentos ácidos (Ácido Fluorídrico entre outros ácidos) em sua superfície e o efeito da irradiação por feixe de laser Yb:YAG. Para a avaliação da união cerâmica/dentina foram realizados ensaios mecânicos de cisalhamento por extrusão, empregando-se corpos de prova cimentados com cimento resinoso (Panavia F, Kuraray Medical Inc., Okayama, Japan), em discos de dentina bovina. Os corpos de prova foram selecionados aleatoriamente para análise de superfície empregando-se microscopia eletrônica de varredura (MEV) antes de qualquer modificação superficial, após as modificações de superfície e após os ensaios mecânicos, e Difração de raios X, a fim de se observar a fase da zircônia existente em cada amostra
Dentistry does not present specific recommendation regarding the appropriate treatment of surface of the zirconia based ceramics in order to improve their adhesion to dentin. This research studied the Physical-Chemical properties of various surface treatments applied to specimens made of yttria-stabilized zirconia (Lava Frame Y-TZP, 3M ESPE), used in metal-free restorations. Will apply different conditioning acids (Hydrofluoric Acid and other acids) on the surface and the effect of irradiation by the laser Yb:YAG beam. To evaluate the ceramic / dentin union were performed mechanical tests shear extrusion, using specimens cemented with resin cement (Panavia F, Kuraray Medical Inc., Okayama, Japan) in bovine dentin discs. Specimens are randomly selected for surface analysis employing electron microscopy (SEM) before any surface modification, after the surface modifications and after the mechanical tests, and X-ray diffraction, to identify the phase of zirconia in each sample
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Damatto, Ricardo Luiz [UNESP]. "Caracterização morfológica, bioquímica e molecular do músculo esquelético sóleo de ratos espontaneamente hipertensos com insuficiência cardíaca". Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/92160.
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damatto_rl_me_botfm.pdf: 863048 bytes, checksum: 20cdd00e6c2f8499693cd4baea8e854d (MD5)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
A insuficiência cardíaca (IC) caracteriza-se por redução da tolerância aos exercícios com a ocorrência precoce de fadiga e dispnéia. Além de disfunção cardíaca e pulmonar, anormalidades intrínsicas da musculatura esquelética têm sido responsabilizadas pela intolerância aos esforços físicos. Em músculos periféricos e respiratórios, frequentemente são observadas atrofia e modificação nas isoformas das cadeias pesadas de miosina (MyHC) na IC. Os mecanismos e vias intracelulares de sinalização responsáveis por essas alterações ainda não estão completamente definidos. Em modelos experimentais de IC induzida por estenose aórtica ou infarto do miocárdio, verificamos que alterações na expressão dos fatores de regulação miogênica e da via miostatina/folistatina podem modular o trofismo muscular e a composição das MyHCs. Um dos modelos experimentais muito utilizados para o estudo da IC é o rato espontaneamente hipertenso (SHR). Estes animais apresentam, precocemente, hipertensão arterial e hipertrofia ventricular esquerda e, em idade avançada, desenvolvem IC. Não identificamos estudos que avaliaram o comprometimento da musculatura esquelética de SHR com IC. O objetivo deste estudo foi caracterizar as alterações da musculatura esquelética de SHR com IC por meio de avaliação da morfologia, das isoformas das cadeias pesadas de miosina e da expressão gênica e protéica dos fatores de regulação miogênica e da via miostatina/folistatina. A partir de 18 meses de idade, ratos espontaneamente hipertensos foram avaliados duas vezes por semana à procura de evidências clínicas de IC como taquipnéia, perda de peso e apatia. Após a detecção de IC, os animais foram submetidos a ecocardiograma transtorácico para a confirmação de disfunção ventricular e eutanasiados. No momento da eutanásia, foram...
Heart failure (HF) is characterized by limited exercise tolerance due to increased muscle fatigue and impaired endurance. Besides cardiac and pulmonary dysfunction, intrinsic skeletal muscle abnormalities have been shown to be involved on reduced exercise tolerance. muscle mass loss and a shift in myosin heavy chain (MyHC) isoforms have been frequently observed in peripheral and respiratory skeletal muscles during HF. The pathophysiological mechanisms and intracellular pathways responsible for muscle changes are not completely defined. We observed that myogenic regulatory factors expression and myostation/follistatin pathway modulate muscle trophism and MyHC isoforms in experimental aortic stenosis- and myocardial infarction-induced HF. The spontaneously hypertensive rat (SHR) is often used in HF studies. These rats develop systemic arterial hypertension and left ventricular hypertrophy early and HF at 18-22 month-age approximately. To the best of our knowledgement, there is not study on skeletal muscle evaluation in SHR with HF. The aim of this study was to characterize skeletal myopathy of SHR with HF by evaluating soleus muscle morphology, MyHC isoforms, and gene and protein expression of myogenic regulatory factors, myostatin, and follistatin. Eighteen month-old spontaneously hypertensive rats were evaluated twice a week to identify HF clinical features such as taquipnea, weight loss, and apathy. After detecting HF, rats were subjected to transthoracic echocardiogram. During euthanasia, we evaluated pathological evidences of HF such as pleuropericardial effusion, ascites, left atrial thrombi, right ventricular hypertrophy, and lung congestion. Agematched Wistar-Kyoto rats used as controls. Soleus morphology was analyzed in haematoxyin and eosin and picro-sirius red stained sections, and MyHC isoforms were evaluated by protein... (Complete abstract click electronic access below)
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Ikefuti, Michelle Venâncio [UNESP]. "Concepções de licenciandos sobre violência sexual e políticas educacionais". Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/92260.
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ikefuti_mv_me_prud.pdf: 758242 bytes, checksum: 0821fff74e861a7d3a03634bdf8620ad (MD5)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
O presente trabalho vinculado à Linha de Pesquisa Processos Formativos, Diferença e Valores, no Programa de Pós-Graduação em Educação da Universidade Estadual Paulista, campus de Presidente Prudente-SP, teve como objetivos identificar o nível de conhecimento que os futuros professores dos cursos de licenciaturas de três campus da Unesp têm acerca da violência sexual e temas afins, bem como elucidar se esta temática é trabalhada dentro dessas faculdades. Dentre as violências domésticas que podem ser cometidas contra crianças e adolescentes, a violência sexual é uma das modalidades mais difíceis de serem detectadas, sendo que a maioria das situações ocorre dentro da casa da vítima, e é cometida muitas vezes por alguém que ela conhece e confia. Diante disso, e sabendo que a escola ocupa um tempo importante na vida das crianças e adolescentes, destacamos que o professor tem um papel fundamental na prevenção, revelação e intervenção de casos de abuso e exploração sexual. A pesquisa foi desenvolvida nos campus da UNESP (Araraquara, Presidente Prudente e São José do Rio Preto), sendo que aplicamos um questionário que contou com a participação dos alunos dos últimos anos de oito cursos de licenciatura (Biologia, Educação Física, Física, Geografia, Letras, Matemática, Pedagogia e Química) totalizando 441 participantes. Foram utilizados os softwares SPSS, versão 12.0 e o EVOC (Ensemble de Programmes Permettant I’ Analyse dês Évocations), versão 2000, para tabular as questões fechadas e as evocações de palavras respectivamente. As análises dos resultados foram feitas utilizando os documentos governamentais que regem a área de Educação no país, além dos Planos Estadual e Nacional de enfrentamento à violência sexual. Como resultados, percebemos que nas três unidades os alunos não se sentem preparados para lidar com casos de violência sexual...
This study is connected with the research line “Formative processes, differences and values” at the Graduate Studies in Education at UNESP, Campus of Presidente Prudente. The research aimed to identify the level of knowledge that future teachers of undergraduate courses of three Campus at Unesp have about the sexual violence and related issues, and to clarify whether this theme was discussed during their course in these Universities. Amongst the domestic violence that can be committed against children, sexual violence is one of the methods more difficult to detect, and most situations occurs inside the victim's home, and it is often committed by someone he knows and trusts. Given this, and knowing that the school occupies an important moment in the lives of children and adolescents, we emphasize that the teacher has a key role in prevention, intervention and revelation of abuse and sexual exploitation. It was developed at the Campus of Araraquara, Presidente Prudente and São José do Rio Preto, and it was applied a questionnaire with students attending the last year of 8 undergraduate courses (Biology, Physical Education, Physics, Geography, Literature, Mathematics, Chemistry and Pedagogy) involving 441 participants. We used SPSS software, version 12.0 and EVOC (Ensemble of Programmes Permettant I 'Analyse des evocations), version 2000, to tabulate the closed questions and word evocations respectively. The analyzes of the results were made using governmental documents that grounded public policies in the field of Education in the country, in addition to the State and National Plans to combat sexual violence. As a result, we realized that in the three Campus students do not feel prepared to handle with cases of sexual violence and most of them never had the issue addressed in any discipline in the process of training... (Complete abstract click electronic access below)
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Santos, Héllen Thaís dos [UNESP]. "A constituição da profissionalização docente em creche: narrativas autobiográficas". Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/92360.
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santos_ht_me_prud.pdf: 1340741 bytes, checksum: 7ccdc1da923a38a9f34c014ed9c2a80f (MD5)Apresentam-se, nesta dissertação, os resultados de pesquisa vinculada à linha Infância e Educação do Programa de Pós-graduação em Educação da Faculdade de Ciências e Tecnologia, da Universidade Estadual Paulista “Júlio Mesquita Filho”, câmpus de Presidente Prudente-SP. Com o objetivo de analisar como se constitui a profissionalização do professor de creche foi realizado um trabalho empírico com as professoras titulares de certificação pelo menos em nível médio, que atuam na modalidade de creche, na rede municipal de Presidente Prudente-SP. Para tanto, o conceito de profissionalização docente é tratado como o processo pelo qual os professores são capazes de adquirir saberes necessários para constituir uma profissão, sendo a formação inicial o marco regulatório deste processo. A formação do professor da educação infantil é, também, discutida a fim de compreender o educar e cuidar como papel do professor de creche. As narrativas autobiográficas são evidenciadas como instrumento de pesquisa e formação de professores, elas estão baseadas no método (auto) biográfico, cujos procedimentos metodológicos permitiram coletar e analisar trajetórias de vida pessoais/profissionais para compreender como se constituiu a profissionalização do professor na creche. Como resultados são evidenciadas as práticas docentes baseadas em saberes advindos da experiência e a necessidade de associação teórico-prática na formação do professor de creche. Além disso, a pesquisa evidencia que a docência em creche está em construção e se configura como uma nova faceta da profissão docente na sociedade moderna, que ainda precisa ser “aceita” pelo professor
In this dissertation are presented the results of a research linked to the Childhood and Education line of the Education Graduate Program in Faculty of Sciences and Technology, São Paulo State University Júlio Mesquita Filho, Presidente Prudente-SP campus. Aiming to analyze the constitution of professionalization of daycare teachers, empirical work was performed with teachers, with at least mid-level certification, who act in daycare centers, in Presidente Prudente - SP. Thus, the concept of teacher professionalization is treated as the process by which teachers are able to acquire knowledge necessary to constitute a profession, considering the initial formation as the regulatory framework of this process. The formation of childhood teachers is also discussed in order to understand the educating and caring teacher's role as day care teachers. Autobiographical narratives are evidenced as a tool for research and teacher formation, that are based on the method (auto) biographical, whose methodological procedures , allowed collect and analyze trajectories of personal/professional life to understand how was the constitution of teacher professionalization in daycare centers. The results evidenced teaching practices based in knowledge experiences , and need of association of theory and practice in formation of daycare center teachers . Moreover , this research shows that teaching in daycare is under construction and is configured as a new facet of the teaching profession in modern society , which still needs to be accepted by the teacher
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Porto, Marília de Paula [UNESP]. "Ação moduladora do citral e eugenol em eventos genéticos em magrófagos murinos in vitro". Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/92460.
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porto_mp_me_botib.pdf: 2132236 bytes, checksum: b1dd297e7ebc3769eafbc4dbcaa5705a (MD5)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Devido a propriedades terapêuticas, várias plantas e seus constituintes químicos vêm sendo muitas vezes utilizados como o primeiro recurso para o tratamento de diversas doenças. Nesse contexto, compostos isolados de plantas têm sido alvos de inúmeros estudos que avaliam, além da atividade, seus possíveis mecanismos de ação. Dentre os compostos com potencial quimioprotetor, o citral e o eugenol merecem atenção devido suas estruturas químicas de monoterpeno e de composto fenólico, respectivamente, e por seus potenciais anti-inflamatório, antiparasitário e antioxidante. Considerando que mutação no DNA pode ser a primeira etapa de várias doenças, e que lesões induzidas nessa molécula podem ser prevenidas ou moduladas por compostos naturais, este estudo objetivou avaliar, pelo teste do cometa, o potencial genotóxico do citral (25, 50 e 100 Tg/mL) e do eugenol (0,31, 0,62, 1,24 e 2,48 Tg/mL), após diferentes tempos de tratamento (6, 10, 24 e 30 h) e, também, seus possíveis efeitos moduladores sobre danos induzidos no DNA pela doxorrubicina (DOX), em diferentes protocolos de tratamento (pré, pós e simultaneamente à DOX) e momentos de análise (12, 24 e 36 h), em macrófagos peritoneais de camundongos. Além disso, foi avaliado o potencial toxicogenômico do citral e do eugenol por meio da modulação da expressão dos genes NF-kB1, COX-2 e TNF-α (relacionados a processos inflamatórios) em macrófagos ativados ou não por lipopolissacarideo de bactéria (LPS). Os resultados mostraram que ambos os compostos apresentaram potencial genotóxico. No caso do citral, a genotoxicidade foi observada para as duas maiores concentrações, mas apenas no tempo de 6h; para o eugenol, o aumento de danos no DNA foi detectado para todas as concentrações, em pelo menos um momento de análise. Com relação ao potencial...
Because of the therapeutic properties, several plants and their chemical constituents have been used for treatment of various diseases. Therefore, isolated compounds from plants have been targets of numerous studies that evaluate their activity and mechanisms of action. Among compounds with chemopreventive potential, citral and eugenol have gain attention because of their chemical structures, monoterpene and phenol,respectively, and for their anti-inflammatory, antioxidant and antiparasitic potentials. Since DNA mutation is the first step for some diseases, and since the lesions induced in this molecule can be prevented or modulated by natural compounds, aim of the present study was first to evaluate the genotoxic potential of citral (25, 50 and 100 Tg/mL) and eugenol (0.31, 0.62, 1.24 and 2.48 Tg/mL) at different times after exposure (6, 10, 24 and 30 h), and then, their ability to modulate DNA damage induced by doxorubicin (DOX) at different treatment protocols (pre, post and simultaneous with DOX) and times (12, 24 and 36 h) in mice peritoneal macrophages. In addition, the toxicogenomic potential of citral and eugenol by modulating the expression of NF-KB1, COX-2 and TNF-α (related to inflammatory processes) genes in macrophages activated or not by bacterial lipopolysaccharide (LPS) was also investigated. The results showed that both compounds have genotoxic potential. In the case of citral, genotoxicity was observed for the two major concentrations, but only 6h after the exposure. For eugenol, increased DNA damage was detected for all concentrations, in at least one moment of analysis. Related to the antigenotoxicity, both citral and eugenol presented protective effects at different concentrations and treatment protocols, and the more effective activities were detected at simultaneous and pre-treatment... (Complete abstract click electronic access below)
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Lemos, Marcos Vinícius Antunes de [UNESP]. "Interação genótipo ambiente para perímetro escrotal em bovinos da raça Nelore utilizando normas de reação". Universidade Estadual Paulista (UNESP), 2013. http://hdl.handle.net/11449/92560.
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000736264.pdf: 1121541 bytes, checksum: 010c2d99d683decfb45fc13975d70d2b (MD5)O crescente mercado de carne bovina brasileiro tem sinalizado a busca de rebanhos mais produtivos e com maiores proporções de animais precoces ao abate, de grande importância a seleção para precocidade sexual. Existem evidências que o perímetro escrotal está correlacionado, negativa e favoravelmente, com a idade ao primeiro parto de fêmeas. Portanto, a seleção para aumentar o perímetro escrotal, em longo prazo, deve levar a um aumento na precocidade sexual das fêmeas. No Brasil a pressuposição comumente assumida é a ausência de interação genótipo-ambiente (IGA) nas características de interesse econômico para a raça Nelore. Ainda são escassos os estudos de IGA para características de precocidade sexual, como o perímetro escrotal. O objetivo do presente trabalho foi quantificar a magnitude da IGA sobre o perímetro escrotal ao sobreano em machos da raça Nelore utilizando normas de reação. Foram utilizadas 31.370 medidas de machos da raça Nelore de propriedades localizadas no Sul, Centro-Oeste e Sudeste do Brasil. Os diferentes grupos ou descritores ambientais foram definidos conforme a informação de ano e estação de nascimento, fazenda de origem dos dados e grupo de manejo alimentar (nascimento, desmama e sobreano). Para a estimação dos parâmetros genéticos foi aplicado um modelo animal utilizando análises de regressão aleatória, em análises uni-característica, utilizando polinômios de Legendre como funções base. Para perímetro escrotal foram considerados a idade do animal no momento da avaliação como consequência aleatória foi considerado o efeito genético aditivo do animal. Polinômios de Legendre (de primeiro grau) regredidos sobre os grupos ambientais foram utilizados para modelar o efeito genético aditivo do animal e as (co)variâncias entre a característica estudada nos diferentes ambientes. Foram consideradas classes heterogêneas e homogêneas...
The increasing search on growing market for Brazilian Beef are related to herds more productive and availability of animals for slaughter, as consequence more significant importance for sexual precocity selection. The use of indicator's characteristics to sexual precocity in indirect selection can result in improving of reproductive efficiency of females. There is significant evidence that scrotal circumference is correlated, negatively and positively, with age at first calving females. Therefore, the selection for increasing scrotal circumference in long-term should lead to an increase of sexual precocity in females. Nowadays, several Brazilian summaries for Nellore bulls are published with amount of characteristics with focus in economically important traits, including all large data sets of animals distributed in some regions of the country. These genetics evaluations have the assumption, commonly assumed, of absence the genotype-environment interaction (GxE). Although there are few studies of GxE related to indicator's characteristics to sexual precocity, such as scrotal circumference.The objectives of this study was to verify the occurrence of genotype-environment interaction on the scrotal circumference, as well as studying genetic association between this trait in different environments, in animals of Nellore breed using the approach of reaction norms. We used information from 31,370 male Nellore property located in the south-central and southeastern Brazil. The different groups or environmental descriptors were defined according to information year and season of birth, home farm and data feed management group (birth weaning and yearling). For the estimation of genetic parameters was applied an animal model using random regression analyzes in single-trait analyzes, using Legendre polynomials as basis functions. For scrotal circumference were considered the age of the animal at the ...
Libri sul tema "92C60":
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Veress, Márton, e Szabolcs Leél-Őssy, a cura di. Cave and Karst Systems of Hungary. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92960-2.
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Forde, Susan. Movement as Conflict Transformation. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-92660-5.
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Angelos, Peter, e Raymon H. Grogan, a cura di. Difficult Decisions in Endocrine Surgery. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-92860-9.
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Grünert, Holle. Beschäftigungssystem und Arbeitsmarkt in der DDR. Wiesbaden: VS Verlag für Sozialwissenschaften, 1997. http://dx.doi.org/10.1007/978-3-322-92560-2.
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Purkert, Walter. Brückenkurs Mathematik für Wirtschaftswissenschaftler. Wiesbaden: Vieweg+Teubner Verlag, 2005. http://dx.doi.org/10.1007/978-3-322-92660-9.
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Fellenberg, Günter. Chemie der Umweltbelastung. Wiesbaden: Vieweg+Teubner Verlag, 1990. http://dx.doi.org/10.1007/978-3-322-92760-6.
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Krengel, Ulrich. Einführung in die Wahrscheinlichkeitstheorie und Statistik. Wiesbaden: Vieweg+Teubner Verlag, 1998. http://dx.doi.org/10.1007/978-3-322-92860-3.
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Söhlke, Thomas. Regulatorische Erfassung des Kreditrisikos. Wiesbaden: Gabler Verlag, 2002. http://dx.doi.org/10.1007/978-3-322-92960-0.
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Kühn, Florian P. Sicherheit und Entwicklung in der Weltgesellschaft. Wiesbaden: VS Verlag für Sozialwissenschaften, 2010. http://dx.doi.org/10.1007/978-3-531-92360-4.
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Flad, Carola. Jugend im Dokumentarfilm. Wiesbaden: VS Verlag für Sozialwissenschaften, 2010. http://dx.doi.org/10.1007/978-3-531-92460-1.
Capitoli di libri sul tema "92C60":
1
Orme, R., RA Fricker-Gates e MA Gates. "Ontogeny of Substantia Nigra Dopamine Neurons". In Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra, 3–18. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-92660-4_1.
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Ishida, Yoshiyuki, Tatsuya Kozaki, Yoshikazu Isomura, Sachiko Ito e Ken-ichi Isobe. "Age-Dependent Changes in Dopaminergic Neuron Firing Patterns in Substantia Nigra Pars Compacta". In Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra, 129–33. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-92660-4_10.
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Lima, Marcelo M. S., Angela B. B. Reksidler e Maria A. B. F. Vital. "The Neurobiology of the Substantia Nigra Pars Compacta: from Motor to Sleep Regulation". In Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra, 135–45. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-92660-4_11.
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Cunha, Claudio, Evellyn Claudia Wietzikoski, Mariza Bortolanza, Patricia Andréia Dombrowski, Lucélia Mendes dos Santos, Suelen Lúcio Boschen, Edmar Miyoshi, Maria Aparecida Barbato Frazão Vital, Roseli Boerngen-Lacerda e Roberto Andreatini. "Non‐motor Function of the Midbrain Dopaminergic Neurons". In Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra, 147–60. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-92660-4_12.
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Jones, Catherine R. G., e Marjan Jahanshahi. "The Substantia Nigra, the Basal Ganglia, Dopamine and Temporal Processing". In Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra, 161–71. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-92660-4_13.
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Matteo, Vincenzo, Massimo Pierucci, Arcangelo Benigno, Gergely Orbán, Giuseppe Crescimanno, Ennio Esposito e Giuseppe Giovanni. "Electrophysiological and Neurochemical Characterization of 7-Nitroindazole and Molsidomine Acute and Sub-Chronic Administration Effects in the Dopaminergic Nigrostrial System in Rats". In Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra, 173–82. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-92660-4_14.
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Silva, Camila, Kjell Fuxe e Gerson Chadi. "Involvement of Astroglial Fibroblast Growth Factor-2 and Microglia in the Nigral 6-OHDA Parkinsonism and a Possible Role of Glucocorticoid Hormone on the Glial Mediated Local Trophism and Wound Repair". In Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra, 185–202. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-92660-4_15.
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Eriksen, Nina, Anette Kirstine Stark e Bente Pakkenberg. "Age and Parkinson’s Disease-Related Neuronal Death in the Substantia Nigra Pars Compacta". In Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra, 203–13. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-92660-4_16.
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Corti, Olga, Margot Fournier e Alexis Brice. "Neurodegeneration in Parkinson’s Disease: Genetics Enlightens Physiopathology". In Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra, 215–21. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-92660-4_17.
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Giovanni, Giuseppe, Ennio Esposito e Vincenzo Matteo. "In Vivo Microdialysis in Parkinson’s Research". In Birth, Life and Death of Dopaminergic Neurons in the Substantia Nigra, 223–43. Vienna: Springer Vienna, 2009. http://dx.doi.org/10.1007/978-3-211-92660-4_18.
Atti di convegni sul tema "92C60":
1
"Front Matter: Volume 9260". In Land Surface Remote Sensing II, a cura di Thomas J. Jackson, Jing Ming Chen, Peng Gong e Shunlin Liang. SPIE, 2014. http://dx.doi.org/10.1117/12.2179079.
2
Leach, Colin, e Tony Bamford. "Use of Drilled-in Casing in Slim Deepwater Exploration Wells". In SPE/IADC Drilling Conference. Society of Petroleum Engineers, 2005. http://dx.doi.org/10.2118/92560-ms.
3
Hamada, Gharib Mostafa. "Factor Identfies hydrocarbon recoverability and type". In SPE Middle East Oil and Gas Show and Conference. Society of Petroleum Engineers, 2005. http://dx.doi.org/10.2118/92660-ms.
4
Smidth, Frederik, e Per Wullf. "Development of the Ultimate Ultra Harsh Environment Jack-up Drilling Rigs". In SPE/IADC Drilling Conference. Society of Petroleum Engineers, 2005. http://dx.doi.org/10.2118/92760-ms.
5
Tan, Chee Phuat, Reem Freij-Ayoub, Michael Benedict Clennell, Bahman Tohidi e Jinhai Yang. "Managing Wellbore Instability Risk in Gas Hydrate-Bearing Sediments". In SPE Asia Pacific Oil and Gas Conference and Exhibition. Society of Petroleum Engineers, 2005. http://dx.doi.org/10.2118/92960-ms.
6
Michailidis, A. D., R. K. Stobart e G. P. McTaggart-Cowan. "Low Temperature Combustion (LTC) Optimization and Cycle-by-Cycle Variability Through Injection Optimization and Gas-to-Liquid (GTL) Fuel-Blend Ratio". In ASME 2012 Internal Combustion Engine Division Fall Technical Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/icef2012-92060.
Abstract (sommario):
The advent of common rail technology alongside powerful control systems capable of delivering multiple accurate fuel charges during a single engine cycle has revolutionized the level of control possible in diesel combustion. This technology has opened a new path enabling low-temperature combustion (LTC) to become a viable combustion strategy. The aim of the research work presented within this paper is the understanding of how various engine parameters of LTC optimize the combustion both in terms of emissions and in terms of fuel efficiency. The work continues with an investigation of in-cylinder pressure and IMEP cycle-by-cycle variation. Attention will be given to how repeatability changes throughout the combustion cycle, identifying which parts within the cycle are least likely to follow the mean trend and why. Experiments were formulated to include rail pressure, injection settings of single injection and split-injection of varying dwell times. All injection conditions were phased across several crank-angles to demonstrate the interaction between emissions and efficiency. These tests are then repeated with blends of 30% and 50% gas-to-liquid (GTL)-Diesel blends in order to determine whether there is any change in the trends of repeatability and variance with increasing GTL blend ratio. Compression-ignition has been traditionally regarded as sufficiently stable that such investigation is irrelevant. Major improvements have been made, however, both to the understanding of compression-ignition and its control. Re-assessing and investigating how pressure repeatability fluctuates over the combustion cycle, especially in atypical engine conditions will help our understanding of combustion and facilitate a more accurate optimization of the combustion process.
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Askari, Omid, Hameed Metghalchi, Ali Moghaddas, Siamak Kazemzadeh Hannani e Reza Ebrahimi. "Fundamental Study of Spray and Partially Premixed Combustion of Methane/Air Mixture". In ASME 2012 Internal Combustion Engine Division Fall Technical Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/icef2012-92160.
Abstract (sommario):
This study presents fundamentals of spray and partially premixed combustion characteristics of directly injected methane inside a constant volume combustion chamber (CVCC). The constant volume vessel is a cylinder with inside diameter of 135 mm and inside height of 135 mm. Two end of the vessel are equipped with optical windows. A high speed complementary metal oxide semiconductor (CMOS) camera capable of capturing pictures up to 40,000 frames per second is used to observe flow conditions inside the chamber. The injected fuel jet generates turbulence in the vessel and forms a turbulent heterogeneous fuel–air mixture in the vessel, similar to that in a compressed natural gas (CNG) direct injection engine. The fuel–air mixture is ignited by centrally located electrodes at a given spark delay timing of 1, 40, 75 and 110 milliseconds after fuel injection has been completed to reflect different turbulence intensities. For comparative study, by increasing the spark delay timing to five minutes, a homogeneous premixed mixture is also prepared in the vessel which provides information on laminar homogeneous mixture combustion. Spray development and characterization including spray tip penetration, spray cone angle and overall equivalence ratio were investigated under 30–90 bar fuel pressures and 1–5 bar chamber pressure. Flame propagation images and combustion characteristics were determined via pressure-derived parameters and analyzed at a fuel pressure of 90 bar and a chamber pressure of 1 bar at different stratification ratios (from 0% to 100%) at overall equivalence ratios of 0.6, 0.8 and 1.0. Shorter combustion duration and higher combustion pressure were observed in direct injection-type combustion at all fuel air equivalence ratios compared to those of homogenous combustion.
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El-Gabry, Lamyaa, e Martina Jaskolski. "Offering Engineering Students Global Prospective Through Experiential Learning Project in Wind Energy and Sustainability". In ASME Turbo Expo 2019: Turbomachinery Technical Conference and Exposition. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/gt2019-92060.
Abstract (sommario):
Abstract Students from Princeton University partnered with students from the American University in Cairo in a three-week intensive hands-on field experience in Egypt. The project was to assemble, install and test a wind mill driven pump used for irrigation and to survey communities across Egypt in the Delta and Red Sea coast to assess water needs in these communities. The course offered a perspective on sustainable development in Egypt followed by water and energy resource challenges in Egypt’s diverse geographic areas. Students assembled a wind pump and installed it at the American University in Cairo for testing prior to installation at El Heiz, a desert oasis community in the Western Desert. The students were selected from diverse backgrounds in Mechanical and Aerospace Engineering, Civil and Environmental Engineering, Computer Engineering, and Operations Research and Financial Engineering and learned the value of having diverse teams address engineering problems in a truly global context. This paper presents the case study including lessons learned in implementation of this experiential learning field project.
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Franco, A., D. Diaz e M. Erquiaga. "Finding Natural Fractures and Improving Reservoir Performance in Western Venezuela: An Integrated Approach". In SPE International Petroleum Conference in Mexico. Society of Petroleum Engineers, 2004. http://dx.doi.org/10.2118/92060-ms.
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Lourenc¸o, Marcelo Igor, Theodoro A. Netto, Neilon S. Silva, Paulo Emi´lio Valada˜o de Miranda e Joa˜o Carloes Ribeiro Pla´cido. "Experimental and Numerical Evaluations of Aluminum Drill Pipes Under Cyclic Loads". In 25th International Conference on Offshore Mechanics and Arctic Engineering. ASMEDC, 2006. http://dx.doi.org/10.1115/omae2006-92160.
Abstract (sommario):
Experimental program and numerical analyses were carried out to investigate the fatigue mechanisms of aluminum drill pipes designed and manufactured in compliance with ISO 15546. Material mechanical properties, including S-N curve, were determined through small-scale tests on specimens cut from actual drill pipes. Full-scale experiments were also performed in laboratory. Initially, the tool-joint assembly procedure was actually performed to monitor the resulting strain/stress level in selected points of the aluminum pipe. Three full-scale aluminum drill pipe specimens were then fatigue tested under combined cyclic bending and constant axial tension. In parallel, a finite element model of the tool-joint region, where two drill pipe specimens failed in the fatigue tests, was developed. The model was first used to reproduce the tool-joint assembly. Then, the physical experiments were simulated numerically in order to obtain the actual stress distribution in this region. Good correlation between full-scale and small-scale fatigue tests was obtained by adjusting the strain/stress levels monitored in the full-scale tests in light of the numerical simulations.